ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0140098 catalytic activity, acting on RNA 177/5575 387/18639 0.457364341085271 1.52911461049119 2.45179964968079e-11 3.34670652181428e-08 GO:0140101 catalytic activity, acting on a tRNA 77/5575 139/18639 0.553956834532374 1.85205406974869 3.1545859487323e-10 2.15300491000979e-07 GO:0043021 ribonucleoprotein complex binding 92/5575 177/18639 0.519774011299435 1.73777000836057 6.04715638632344e-10 2.75145615577716e-07 GO:0019787 ubiquitin-like protein transferase activity 202/5575 479/18639 0.421711899791232 1.40991714801951 5.4358853526737e-09 1.8549958765999e-06 GO:0016755 aminoacyltransferase activity 207/5575 496/18639 0.417338709677419 1.39529618110806 9.70609288601282e-09 2.6497633578815e-06 GO:0016741 transferase activity, transferring one-carbon groups 103/5575 215/18639 0.47906976744186 1.60168276149755 1.88599118827767e-08 4.2906299533317e-06 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 84/5575 167/18639 0.502994011976048 1.68166912811149 2.4166707291941e-08 4.7125079219285e-06 GO:0008168 methyltransferase activity 98/5575 204/18639 0.480392156862745 1.60610393036138 3.47763874202872e-08 5.9337211035865e-06 GO:0043022 ribosome binding 61/5575 112/18639 0.544642857142857 1.82091447789878 4.94782808819954e-08 7.5042059337693e-06 GO:0004842 ubiquitin-protein transferase activity 187/5575 449/18639 0.416481069042316 1.39242881540444 5.95692673547678e-08 8.1312049939258e-06 GO:0005525 GTP binding 161/5575 378/18639 0.425925925925926 1.42400597907324 8.74296520289909e-08 1.08492250017793e-05 GO:0016779 nucleotidyltransferase activity 68/5575 136/18639 0.5 1.67165919282511 6.66824829922725e-07 6.76950853060304e-05 GO:0016853 isomerase activity 85/5575 180/18639 0.472222222222222 1.57878923766816 6.85936278630526e-07 6.76950853060304e-05 GO:0051082 unfolded protein binding 62/5575 121/18639 0.512396694214876 1.71310528851499 6.94308567241337e-07 6.76950853060304e-05 GO:0051537 2 iron, 2 sulfur cluster binding 21/5575 28/18639 0.75 2.50748878923767 1.09221741206945e-06 9.76530793747956e-05 GO:0019001 guanyl nucleotide binding 164/5575 400/18639 0.41 1.37076053811659 1.21619219734178e-06 9.76530793747956e-05 GO:0032561 guanyl ribonucleotide binding 164/5575 400/18639 0.41 1.37076053811659 1.21619219734178e-06 9.76530793747956e-05 GO:0061650 ubiquitin-like protein conjugating enzyme activity 27/5575 41/18639 0.658536585365854 2.20169747347698 2.10306359746967e-06 0.000159482322808117 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 63/5575 128/18639 0.4921875 1.64553951793722 3.32967870720165e-06 0.000239211128175276 GO:0008170 N-methyltransferase activity 51/5575 98/18639 0.520408163265306 1.73989018028736 3.65628794053164e-06 0.000249541651941284 GO:0003712 transcription coregulator activity 194/5575 495/18639 0.391919191919192 1.31031064003261 4.95346757590269e-06 0.000321975392433675 GO:0044389 ubiquitin-like protein ligase binding 133/5575 322/18639 0.41304347826087 1.38093585494248 7.66465211190902e-06 0.000475556824216173 GO:0000287 magnesium ion binding 99/5575 230/18639 0.430434782608696 1.43908052251901 1.48422076348316e-05 0.000880852757458483 GO:0140662 ATP-dependent protein folding chaperone 25/5575 40/18639 0.625 2.08957399103139 1.96878018685974e-05 0.00111974373127648 GO:0031625 ubiquitin protein ligase binding 124/5575 302/18639 0.410596026490066 1.37275324443916 2.13064237280753e-05 0.00116333073555291 GO:0003924 GTPase activity 134/5575 331/18639 0.404833836858006 1.35348840990069 2.31395598092374e-05 0.00116366785569855 GO:0008135 translation factor activity, RNA binding 43/5575 83/18639 0.518072289156627 1.73208060943325 2.3848454906284e-05 0.00116366785569855 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 31/5575 54/18639 0.574074074074074 1.91931240657698 2.3870109860483e-05 0.00116366785569855 GO:0070063 RNA polymerase binding 33/5575 59/18639 0.559322033898305 1.86999163943148 2.75092907871642e-05 0.0012948338594648 GO:0180051 translation factor activity 43/5575 84/18639 0.511904761904762 1.71146060217809 3.4805311776999e-05 0.00158364168585345 GO:0008173 RNA methyltransferase activity 36/5575 67/18639 0.537313432835821 1.79640987885684 3.91275015743533e-05 0.00172287224674168 GO:0061659 ubiquitin-like protein ligase activity 147/5575 372/18639 0.395161290322581 1.32115000723275 4.12040189656407e-05 0.00175760893400311 GO:0008276 protein methyltransferase activity 47/5575 95/18639 0.494736842105263 1.65406278026906 4.74533240279967e-05 0.00192201023950181 GO:0019003 GDP binding 39/5575 75/18639 0.52 1.73852556053812 5.04294616043393e-05 0.00192201023950181 GO:0044183 protein folding chaperone 39/5575 75/18639 0.52 1.73852556053812 5.04294616043393e-05 0.00192201023950181 GO:0000049 tRNA binding 41/5575 80/18639 0.5125 1.71345067264574 5.0690379942905e-05 0.00192201023950181 GO:0061631 ubiquitin conjugating enzyme activity 22/5575 35/18639 0.628571428571429 2.10151441383728 5.48247135564674e-05 0.00202258740552914 GO:0016763 pentosyltransferase activity 28/5575 49/18639 0.571428571428571 1.91046764894299 6.57793115118159e-05 0.00236286211088496 GO:0051536 iron-sulfur cluster binding 39/5575 76/18639 0.513157894736842 1.71565022421525 7.38761674411172e-05 0.00255224220321279 GO:0015036 disulfide oxidoreductase activity 24/5575 40/18639 0.6 2.00599103139013 7.47909803139278e-05 0.00255224220321279 GO:0031072 heat shock protein binding 60/5575 131/18639 0.458015267175573 1.53129086365659 8.54126586777314e-05 0.00280746479916784 GO:0004527 exonuclease activity 42/5575 84/18639 0.5 1.67165919282511 8.63835322820873e-05 0.00280746479916784 GO:0003756 protein disulfide isomerase activity 14/5575 19/18639 0.736842105263158 2.46349775784753 0.000103666290274448 0.00321601105055959 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 14/5575 19/18639 0.736842105263158 2.46349775784753 0.000103666290274448 0.00321601105055959 GO:0051540 metal cluster binding 39/5575 77/18639 0.506493506493506 1.69336905247219 0.000106784666814678 0.00323913489337856 GO:0008175 tRNA methyltransferase activity 21/5575 34/18639 0.617647058823529 2.06499076760749 0.000116972357224854 0.00347102755678098 GO:0016860 intramolecular oxidoreductase activity 29/5575 53/18639 0.547169811320755 1.82936289026144 0.000141484059893799 0.00410905833521352 GO:0061630 ubiquitin protein ligase activity 137/5575 353/18639 0.388101983002833 1.29754849528068 0.000191759514320474 0.00545316118848847 GO:0003925 G protein activity 29/5575 54/18639 0.537037037037037 1.79548579970105 0.000218758572715174 0.00609398881135128 GO:0140297 DNA-binding transcription factor binding 182/5575 488/18639 0.372950819672131 1.24689333235316 0.000235904494181084 0.00644019269114358 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 135/5575 349/18639 0.386819484240688 1.29326069358963 0.000251229811197943 0.00672409200559199 GO:0004532 RNA exonuclease activity 23/5575 40/18639 0.575 1.92240807174888 0.000257615087540919 0.00676239604794911 GO:0051020 GTPase binding 123/5575 315/18639 0.39047619047619 1.30548622677771 0.000297213119278212 0.0076546397700898 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 22/5575 38/18639 0.578947368421053 1.93560538116592 0.000305977976200429 0.00773444328728862 GO:0044390 ubiquitin-like protein conjugating enzyme binding 21/5575 36/18639 0.583333333333333 1.95026905829596 0.000362773570338351 0.00900338042748817 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 15/5575 23/18639 0.652173913043478 2.18042503411971 0.000488502887301611 0.0117155246970871 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 31/5575 61/18639 0.508196721311475 1.69906344188782 0.000489219712625614 0.0117155246970871 GO:0060590 ATPase regulator activity 26/5575 49/18639 0.530612244897959 1.77400567401849 0.000585024394097721 0.0135532569513981 GO:0031624 ubiquitin conjugating enzyme binding 18/5575 30/18639 0.6 2.00599103139013 0.000595747558303212 0.0135532569513981 GO:0035925 mRNA 3'-UTR AU-rich region binding 18/5575 30/18639 0.6 2.00599103139013 0.000595747558303212 0.0135532569513981 GO:0070402 NADPH binding 12/5575 17/18639 0.705882352941177 2.35998944869428 0.00063284670204603 0.0141612417752923 GO:0043175 RNA polymerase core enzyme binding 23/5575 42/18639 0.547619047619048 1.83086483023703 0.00066954587699479 0.0147408084209337 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 39/5575 83/18639 0.469879518072289 1.57095683181155 0.0007558226986491 0.0163761584707305 GO:0016278 lysine N-methyltransferase activity 34/5575 70/18639 0.485714285714286 1.62389750160154 0.000773398223284794 0.016495133980996 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 30/5575 60/18639 0.5 1.67165919282511 0.000849012074025233 0.0167498798101329 GO:0043539 protein serine/threonine kinase activator activity 35/5575 73/18639 0.479452054794521 1.6029608698323 0.000878226044907881 0.0167498798101329 GO:0033192 calmodulin-dependent protein phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0140791 histone H2AXS140 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:1990439 MAP kinase serine/threonine phosphatase activity 38/5575 81/18639 0.469135802469136 1.56847035376183 0.000911414821516842 0.0167498798101329 GO:0003727 single-stranded RNA binding 41/5575 89/18639 0.460674157303371 1.54018037990628 0.000920323066490817 0.0167498798101329 GO:0008408 3'-5' exonuclease activity 29/5575 58/18639 0.5 1.67165919282511 0.00102940254416808 0.0184886114840714 GO:0140767 enzyme-substrate adaptor activity 59/5575 139/18639 0.424460431654676 1.41910636513211 0.00110204459216916 0.0195362450429988 GO:0000993 RNA polymerase II complex binding 20/5575 36/18639 0.555555555555556 1.85739910313901 0.00116921453069721 0.0204612542872012 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 38/5575 82/18639 0.463414634146341 1.54934266652084 0.00121410763510943 0.0207157115240546 GO:0033549 MAP kinase phosphatase activity 38/5575 82/18639 0.463414634146341 1.54934266652084 0.00121410763510943 0.0207157115240546 GO:0043024 ribosomal small subunit binding 13/5575 20/18639 0.65 2.17315695067265 0.00123262584166673 0.0207412096353381 GO:0051087 protein-folding chaperone binding 57/5575 134/18639 0.425373134328358 1.42215782076166 0.00124599208065768 0.0207412096353381 GO:0003743 translation initiation factor activity 26/5575 51/18639 0.509803921568627 1.70443682405698 0.00128100834543344 0.0208705090089624 GO:0016279 protein-lysine N-methyltransferase activity 33/5575 69/18639 0.478260869565217 1.59897835835446 0.00128433901593615 0.0208705090089624 GO:0008409 5'-3' exonuclease activity 12/5575 18/18639 0.666666666666667 2.22887892376682 0.00138151806071947 0.0221855547397892 GO:0015035 protein-disulfide reductase activity 19/5575 34/18639 0.558823529411765 1.8683249802163 0.00140698960261396 0.0223318698554425 GO:0004518 nuclease activity 83/5575 209/18639 0.397129186602871 1.3277293110477 0.00149314176179621 0.0234268793661129 GO:0031996 thioesterase binding 8/5575 10/18639 0.8 2.67465470852018 0.00155176262651652 0.0236565223013179 GO:0001222 transcription corepressor binding 25/5575 49/18639 0.510204081632653 1.70577468655624 0.00155516666795211 0.0236565223013179 GO:0043014 alpha-tubulin binding 23/5575 44/18639 0.522727272727273 1.74764370158989 0.0015597707011858 0.0236565223013179 GO:0008474 palmitoyl-(protein) hydrolase activity 10/5575 14/18639 0.714285714285714 2.38808456117873 0.00161739644601899 0.0238125138819909 GO:0098599 palmitoyl hydrolase activity 10/5575 14/18639 0.714285714285714 2.38808456117873 0.00161739644601899 0.0238125138819909 GO:0031267 small GTPase binding 108/5575 283/18639 0.381625441696113 1.2758953556545 0.00168100302379675 0.0238125138819909 GO:0030515 snoRNA binding 18/5575 32/18639 0.5625 1.88061659192825 0.00169217131615613 0.0238125138819909 GO:0051059 NF-kappaB binding 18/5575 32/18639 0.5625 1.88061659192825 0.00169217131615613 0.0238125138819909 GO:0070717 poly-purine tract binding 18/5575 32/18639 0.5625 1.88061659192825 0.00169217131615613 0.0238125138819909 GO:0140142 nucleocytoplasmic carrier activity 18/5575 32/18639 0.5625 1.88061659192825 0.00169217131615613 0.0238125138819909 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 14/5575 23/18639 0.608695652173913 2.0350633651784 0.00201017983934694 0.0274844269725979 GO:0001098 basal transcription machinery binding 29/5575 60/18639 0.483333333333333 1.61593721973094 0.00201542941912316 0.0274844269725979 GO:0001099 basal RNA polymerase II transcription machinery binding 29/5575 60/18639 0.483333333333333 1.61593721973094 0.00201542941912316 0.0274844269725979 GO:0008187 poly-pyrimidine tract binding 17/5575 30/18639 0.566666666666667 1.89454708520179 0.00203364624485889 0.0274844269725979 GO:0017018 myosin phosphatase activity 38/5575 84/18639 0.452380952380952 1.5124535554132 0.00209101818604036 0.0279827433720107 GO:0016757 glycosyltransferase activity 102/5575 267/18639 0.382022471910112 1.27722275406862 0.00213407654321788 0.0282816939950719 GO:0000175 3'-5'-RNA exonuclease activity 19/5575 35/18639 0.542857142857143 1.81494426649584 0.00222137452297407 0.0291555406140347 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 21/5575 40/18639 0.525 1.75524215246637 0.00229932487265873 0.0298912233445634 GO:0003714 transcription corepressor activity 80/5575 204/18639 0.392156862745098 1.3111052492746 0.00269687148775523 0.0347285809508102 GO:0004659 prenyltransferase activity 11/5575 17/18639 0.647058823529412 2.16332366130309 0.00313855447365223 0.0398583067672974 GO:0005048 signal sequence binding 25/5575 51/18639 0.490196078431373 1.63888156159325 0.00315362427169825 0.0398583067672974 GO:0016791 phosphatase activity 103/5575 273/18639 0.377289377289377 1.2613985118021 0.00320479834068956 0.0401334838077179 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 51/5575 122/18639 0.418032786885246 1.39761670219804 0.00337211172886693 0.0418448409991214 GO:0000774 adenyl-nucleotide exchange factor activity 10/5575 15/18639 0.666666666666667 2.22887892376682 0.00355186515028078 0.0436783417129123 GO:0004722 protein serine/threonine phosphatase activity 44/5575 103/18639 0.427184466019417 1.42821367930689 0.00383370834419063 0.0467233204448233 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 9/5575 13/18639 0.692307692307692 2.31460503621939 0.00392923102951545 0.0474637199583061 GO:0019843 rRNA binding 30/5575 65/18639 0.461538461538462 1.54307002414626 0.00409742067700279 0.0484976119145623 GO:0004860 protein kinase inhibitor activity 37/5575 84/18639 0.44047619047619 1.47265214606022 0.00414924358459455 0.0484976119145623 GO:0034062 5'-3' RNA polymerase activity 13/5575 22/18639 0.590909090909091 1.97559722788422 0.0041842249632883 0.0484976119145623 GO:0097747 RNA polymerase activity 13/5575 22/18639 0.590909090909091 1.97559722788422 0.0041842249632883 0.0484976119145623 GO:0140537 transcription regulator activator activity 8/5575 11/18639 0.727272727272727 2.43150428047289 0.00419246755012333 0.0484976119145623 GO:0030145 manganese ion binding 31/5575 68/18639 0.455882352941176 1.52415985228172 0.00447471340226946 0.051327594908385 GO:0019887 protein kinase regulator activity 96/5575 255/18639 0.376470588235294 1.25866103930361 0.00463628124509256 0.052597712330949 GO:0019210 kinase inhibitor activity 39/5575 90/18639 0.433333333333333 1.44877130044843 0.00466250783299988 0.052597712330949 GO:0008266 poly(U) RNA binding 15/5575 27/18639 0.555555555555556 1.85739910313901 0.00478050419045628 0.0534867886883019 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 12/5575 20/18639 0.6 2.00599103139013 0.00497989975101848 0.0552647411393514 GO:0003713 transcription coactivator activity 96/5575 256/18639 0.375 1.25374439461883 0.00527200190655012 0.0580345371164589 GO:0070566 adenylyltransferase activity 16/5575 30/18639 0.533333333333333 1.78310313901345 0.006132819630232 0.0669703903621335 GO:0016922 nuclear receptor binding 55/5575 137/18639 0.401459854014599 1.34220811102746 0.00660831973170984 0.0715901304268566 GO:0140104 molecular carrier activity 93/5575 249/18639 0.373493975903614 1.24870927656816 0.00675848528234117 0.0726404126802811 GO:0003735 structural constituent of ribosome 68/5575 175/18639 0.388571428571429 1.29911800128123 0.00683902118021728 0.0729317493046609 GO:0015923 mannosidase activity 10/5575 16/18639 0.625 2.08957399103139 0.00694295014933503 0.0734661004173823 GO:0016866 intramolecular transferase activity 15/5575 28/18639 0.535714285714286 1.79106342088405 0.0074792114839244 0.0785317205812062 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 22/5575 46/18639 0.478260869565217 1.59897835835446 0.00785426868061047 0.0818402805269717 GO:0019207 kinase regulator activity 105/5575 287/18639 0.365853658536585 1.22316526304276 0.00846824619341546 0.0875693640455463 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 18/5575 36/18639 0.5 1.67165919282511 0.00891919499736826 0.0886215950735232 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 18/5575 36/18639 0.5 1.67165919282511 0.00891919499736826 0.0886215950735232 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 18/5575 36/18639 0.5 1.67165919282511 0.00891919499736826 0.0886215950735232 GO:0140789 histone phosphatase activity 54/5575 136/18639 0.397058823529412 1.32749406489053 0.00911482017943238 0.0886215950735232 GO:0097602 cullin family protein binding 14/5575 26/18639 0.538461538461538 1.80024836150397 0.00912936511940172 0.0886215950735232 GO:0070273 phosphatidylinositol-4-phosphate binding 16/5575 31/18639 0.516129032258065 1.72558368291624 0.00919910441310019 0.0886215950735232 GO:0016423 tRNA (guanine) methyltransferase activity 8/5575 12/18639 0.666666666666667 2.22887892376682 0.00928416710294053 0.0886215950735232 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 8/5575 12/18639 0.666666666666667 2.22887892376682 0.00928416710294053 0.0886215950735232 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 8/5575 12/18639 0.666666666666667 2.22887892376682 0.00928416710294053 0.0886215950735232 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 8/5575 12/18639 0.666666666666667 2.22887892376682 0.00928416710294053 0.0886215950735232 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 8/5575 12/18639 0.666666666666667 2.22887892376682 0.00928416710294053 0.0886215950735232 GO:0030020 extracellular matrix structural constituent conferring tensile strength 21/5575 44/18639 0.477272727272727 1.59567468406033 0.00956284188573236 0.090647772041838 GO:0046527 glucosyltransferase activity 11/5575 19/18639 0.578947368421053 1.93560538116592 0.0102557165907557 0.0951545771322953 GO:0005528 FK506 binding 7/5575 10/18639 0.7 2.34032286995516 0.0103868366246974 0.0951545771322953 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/5575 10/18639 0.7 2.34032286995516 0.0103868366246974 0.0951545771322953 GO:0008641 ubiquitin-like modifier activating enzyme activity 7/5575 10/18639 0.7 2.34032286995516 0.0103868366246974 0.0951545771322953 GO:0030957 Tat protein binding 7/5575 10/18639 0.7 2.34032286995516 0.0103868366246974 0.0951545771322953 GO:0140097 catalytic activity, acting on DNA 120/5575 336/18639 0.357142857142857 1.19404228058937 0.0120490760225152 0.109071415045157 GO:0140030 modification-dependent protein binding 66/5575 173/18639 0.38150289017341 1.27548562689546 0.01206577558375 0.109071415045157 GO:0051787 misfolded protein binding 10/5575 17/18639 0.588235294117647 1.9666578739119 0.0123778011145962 0.111155911325156 GO:0016251 RNA polymerase II general transcription initiation factor activity 24/5575 53/18639 0.452830188679245 1.51395549538878 0.0127534033223914 0.113780362974276 GO:0001221 transcription coregulator binding 46/5575 115/18639 0.4 1.33732735426009 0.0131284490415478 0.11636579832281 GO:0003697 single-stranded DNA binding 48/5575 121/18639 0.396694214876033 1.32627506207612 0.0136088099413681 0.117860952697306 GO:0004540 RNA nuclease activity 48/5575 121/18639 0.396694214876033 1.32627506207612 0.0136088099413681 0.117860952697306 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 12/5575 22/18639 0.545454545454545 1.82362821035467 0.0136425132059886 0.117860952697306 GO:0140517 protein-RNA adaptor activity 12/5575 22/18639 0.545454545454545 1.82362821035467 0.0136425132059886 0.117860952697306 GO:0019783 ubiquitin-like protein peptidase activity 50/5575 127/18639 0.393700787401575 1.31626708096466 0.0140347012918749 0.12048193369835 GO:0061791 GTPase motor activity 19/5575 40/18639 0.475 1.58807623318386 0.0142106896157028 0.12048193369835 GO:1990606 membrane scission GTPase motor activity 19/5575 40/18639 0.475 1.58807623318386 0.0142106896157028 0.12048193369835 GO:0004559 alpha-mannosidase activity 9/5575 15/18639 0.6 2.00599103139013 0.0148985354741016 0.12553395630956 GO:0140566 histone reader activity 17/5575 35/18639 0.485714285714286 1.62389750160154 0.0153998001374231 0.128961516488237 GO:0004721 phosphoprotein phosphatase activity 66/5575 175/18639 0.377142857142857 1.26090864830237 0.0158812541443295 0.132182389676889 GO:0061608 nuclear import signal receptor activity 11/5575 20/18639 0.55 1.83882511210762 0.0167039371726568 0.138187116610161 GO:0008139 nuclear localization sequence binding 13/5575 25/18639 0.52 1.73852556053812 0.016965747152611 0.139507499176591 GO:0009982 pseudouridine synthase activity 8/5575 13/18639 0.615384615384615 2.05742669886168 0.0178520648204207 0.145048026665918 GO:0140666 annealing activity 8/5575 13/18639 0.615384615384615 2.05742669886168 0.0178520648204207 0.145048026665918 GO:0016874 ligase activity 63/5575 167/18639 0.377245508982036 1.26125184608362 0.0180062008112809 0.145434698860346 GO:0140416 transcription regulator inhibitor activity 16/5575 33/18639 0.484848484848485 1.62100285364859 0.0188644349612668 0.151470316012524 GO:0140318 protein transporter activity 19/5575 41/18639 0.463414634146341 1.54934266652084 0.0191953979627124 0.153226422333932 GO:0003746 translation elongation factor activity 10/5575 18/18639 0.555555555555556 1.85739910313901 0.0204755378903725 0.160081939887298 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 10/5575 18/18639 0.555555555555556 1.85739910313901 0.0204755378903725 0.160081939887298 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 10/5575 18/18639 0.555555555555556 1.85739910313901 0.0204755378903725 0.160081939887298 GO:0008171 O-methyltransferase activity 12/5575 23/18639 0.521739130434783 1.74434002729577 0.0208774545677083 0.160081939887298 GO:0005484 SNAP receptor activity 17/5575 36/18639 0.472222222222222 1.57878923766816 0.021198236315367 0.160081939887298 GO:0019206 nucleoside kinase activity 7/5575 11/18639 0.636363636363636 2.12756624541378 0.0212269825052021 0.160081939887298 GO:0032404 mismatch repair complex binding 7/5575 11/18639 0.636363636363636 2.12756624541378 0.0212269825052021 0.160081939887298 GO:0048407 platelet-derived growth factor binding 7/5575 11/18639 0.636363636363636 2.12756624541378 0.0212269825052021 0.160081939887298 GO:0070990 snRNP binding 7/5575 11/18639 0.636363636363636 2.12756624541378 0.0212269825052021 0.160081939887298 GO:0180030 inositol phosphate kinase activity 7/5575 11/18639 0.636363636363636 2.12756624541378 0.0212269825052021 0.160081939887298 GO:0016887 ATP hydrolysis activity 144/5575 417/18639 0.345323741007194 1.15452721231087 0.0221563925898047 0.166172944423535 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 25/5575 58/18639 0.431034482758621 1.44108551105613 0.0223972020871381 0.16706109753521 GO:0008234 cysteine-type peptidase activity 69/5575 187/18639 0.368983957219251 1.2336308481811 0.0233328396774522 0.172555569890298 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 18/5575 39/18639 0.461538461538462 1.54307002414626 0.0233866523294544 0.172555569890298 GO:0015605 organophosphate ester transmembrane transporter activity 22/5575 50/18639 0.44 1.4710600896861 0.0241010082087674 0.176870302177244 GO:0070006 metalloaminopeptidase activity 13/5575 26/18639 0.5 1.67165919282511 0.0248021291858203 0.179573576791172 GO:0009055 electron transfer activity 45/5575 116/18639 0.387931034482759 1.29697695995052 0.0249510596451761 0.179573576791172 GO:0016722 oxidoreductase activity, acting on metal ions 9/5575 16/18639 0.5625 1.88061659192825 0.0251271451773728 0.179573576791172 GO:0030275 LRR domain binding 9/5575 16/18639 0.5625 1.88061659192825 0.0251271451773728 0.179573576791172 GO:0043023 ribosomal large subunit binding 9/5575 16/18639 0.5625 1.88061659192825 0.0251271451773728 0.179573576791172 GO:0016859 cis-trans isomerase activity 19/5575 42/18639 0.452380952380952 1.5124535554132 0.0254266271662493 0.180042858004234 GO:0042054 histone methyltransferase activity 28/5575 67/18639 0.417910447761194 1.39720768355532 0.0254566092269723 0.180042858004234 GO:0010314 phosphatidylinositol-5-phosphate binding 11/5575 21/18639 0.523809523809524 1.75126201153107 0.025746476481612 0.181154331945362 GO:0052866 phosphatidylinositol phosphate phosphatase activity 16/5575 34/18639 0.470588235294118 1.57332629912952 0.0259341101440269 0.181538771008188 GO:0140597 protein carrier chaperone 69/5575 188/18639 0.367021276595745 1.22706898196737 0.0263092294578023 0.183224990866837 GO:0046915 transition metal ion transmembrane transporter activity 20/5575 45/18639 0.444444444444444 1.48591928251121 0.027319694255095 0.188340316455579 GO:0051539 4 iron, 4 sulfur cluster binding 20/5575 45/18639 0.444444444444444 1.48591928251121 0.027319694255095 0.188340316455579 GO:0106310 protein serine kinase activity 125/5575 361/18639 0.346260387811634 1.15765872079301 0.0287224891467223 0.197016068770231 GO:0032266 phosphatidylinositol-3-phosphate binding 21/5575 48/18639 0.4375 1.46270179372197 0.0290702369846403 0.19840436742017 GO:0030544 Hsp70 protein binding 22/5575 51/18639 0.431372549019608 1.44221577420206 0.0306843309449255 0.206718933451513 GO:0030983 mismatched DNA binding 8/5575 14/18639 0.571428571428571 1.91046764894299 0.0308674402079027 0.206718933451513 GO:1990825 sequence-specific mRNA binding 8/5575 14/18639 0.571428571428571 1.91046764894299 0.0308674402079027 0.206718933451513 GO:0030331 nuclear estrogen receptor binding 18/5575 40/18639 0.45 1.5044932735426 0.0308942581861602 0.206718933451513 GO:0140223 general transcription initiation factor activity 28/5575 68/18639 0.411764705882353 1.37666051173833 0.0312133713181634 0.2078353748746 GO:0022884 macromolecule transmembrane transporter activity 15/5575 32/18639 0.46875 1.56718049327354 0.0317687884390728 0.20989937934675 GO:0120227 acyl-CoA binding 10/5575 19/18639 0.526315789473684 1.75964125560538 0.0318308948899468 0.20989937934675 GO:0003684 damaged DNA binding 30/5575 74/18639 0.405405405405405 1.35539934553387 0.0329111276290673 0.215979275065754 GO:0101005 deubiquitinase activity 44/5575 115/18639 0.382608695652174 1.27918268668356 0.0334984989813794 0.218782062725277 GO:0001671 ATPase activator activity 13/5575 27/18639 0.481481481481481 1.60974588938714 0.0350065491756921 0.225395941626508 GO:0005385 zinc ion transmembrane transporter activity 13/5575 27/18639 0.481481481481481 1.60974588938714 0.0350065491756921 0.225395941626508 GO:0008320 protein transmembrane transporter activity 13/5575 27/18639 0.481481481481481 1.60974588938714 0.0350065491756921 0.225395941626508 GO:0140035 ubiquitin-like protein reader activity 11/5575 22/18639 0.5 1.67165919282511 0.0378504397572355 0.236518499330241 GO:0004300 enoyl-CoA hydratase activity 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:0005049 nuclear export signal receptor activity 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:0005527 macrolide binding 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:0035251 UDP-glucosyltransferase activity 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:0043047 single-stranded telomeric DNA binding 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:1990817 poly(A) RNA polymerase activity 7/5575 12/18639 0.583333333333333 1.95026905829596 0.0379469240683684 0.236518499330241 GO:0004029 aldehyde dehydrogenase (NAD+) activity 9/5575 17/18639 0.529411764705882 1.76999208652071 0.0394701572479965 0.241599841450741 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 9/5575 17/18639 0.529411764705882 1.76999208652071 0.0394701572479965 0.241599841450741 GO:0004549 tRNA-specific ribonuclease activity 9/5575 17/18639 0.529411764705882 1.76999208652071 0.0394701572479965 0.241599841450741 GO:0032977 membrane insertase activity 9/5575 17/18639 0.529411764705882 1.76999208652071 0.0394701572479965 0.241599841450741 GO:0008094 ATP-dependent activity, acting on DNA 75/5575 210/18639 0.357142857142857 1.19404228058937 0.0398174285891951 0.242637455465408 GO:0003954 NADH dehydrogenase activity 19/5575 44/18639 0.431818181818182 1.44370566653078 0.0422963020844843 0.25546217851912 GO:0016790 thiolester hydrolase activity 19/5575 44/18639 0.431818181818182 1.44370566653078 0.0422963020844843 0.25546217851912 GO:0000030 mannosyltransferase activity 12/5575 25/18639 0.48 1.60479282511211 0.0431865659852837 0.258830865154444 GO:0042578 phosphoric ester hydrolase activity 124/5575 363/18639 0.341597796143251 1.14207019234333 0.0432332873664565 0.258830865154444 GO:0032813 tumor necrosis factor receptor superfamily binding 21/5575 50/18639 0.42 1.40419372197309 0.0461351072981526 0.269317095835622 GO:0015924 mannosyl-oligosaccharide mannosidase activity 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0016427 tRNA (cytidine) methyltransferase activity 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0016783 sulfurtransferase activity 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0033204 ribonuclease P RNA binding 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0047429 nucleoside triphosphate diphosphatase activity 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0099122 RNA polymerase II C-terminal domain binding 6/5575 10/18639 0.6 2.00599103139013 0.0466484774233905 0.269317095835622 GO:0016004 phospholipase activator activity 10/5575 20/18639 0.5 1.67165919282511 0.0469578526072366 0.269317095835622 GO:0030742 GTP-dependent protein binding 10/5575 20/18639 0.5 1.67165919282511 0.0469578526072366 0.269317095835622 GO:0046966 nuclear thyroid hormone receptor binding 13/5575 28/18639 0.464285714285714 1.55225496476618 0.0478854351396986 0.272348412357036 GO:0097718 disordered domain specific binding 13/5575 28/18639 0.464285714285714 1.55225496476618 0.0478854351396986 0.272348412357036 GO:0031005 filamin binding 8/5575 15/18639 0.533333333333333 1.78310313901345 0.0491176170465326 0.27819729157061 GO:0019209 kinase activator activity 54/5575 148/18639 0.364864864864865 1.21985941098049 0.0498959622298671 0.281437968775903 GO:0035198 miRNA binding 18/5575 42/18639 0.428571428571429 1.43285073670724 0.0510173334962503 0.286578848651777 GO:0005164 tumor necrosis factor receptor binding 14/5575 31/18639 0.451612903225806 1.50988572255171 0.0520083450466021 0.290948323723819 GO:0160215 deacylase activity 26/5575 65/18639 0.4 1.33732735426009 0.0527149321789239 0.293697479282576 GO:0140103 catalytic activity, acting on a glycoprotein 11/5575 23/18639 0.478260869565217 1.59897835835446 0.0534090095143018 0.296354869865943 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 27/5575 68/18639 0.397058823529412 1.32749406489053 0.0536269535554271 0.296359480174729 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 20/5575 48/18639 0.416666666666667 1.39304932735426 0.0552099148976537 0.303877152561682 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 15/5575 34/18639 0.441176470588235 1.47499340543392 0.0556184475424163 0.30489630881686 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 80/5575 229/18639 0.349344978165939 1.16797148843676 0.0564851490550632 0.308408913840645 GO:0050660 flavin adenine dinucleotide binding 33/5575 86/18639 0.383720930232558 1.28290124100532 0.0571268652346135 0.310670004164332 GO:0008308 voltage-gated monoatomic anion channel activity 9/5575 18/18639 0.5 1.67165919282511 0.0584647766056207 0.314305064705976 GO:0051287 NAD binding 22/5575 54/18639 0.407407407407407 1.36209267563528 0.0584860706485846 0.314305064705976 GO:0140463 chromatin-protein adaptor activity 22/5575 54/18639 0.407407407407407 1.36209267563528 0.0584860706485846 0.314305064705976 GO:0008143 poly(A) binding 12/5575 26/18639 0.461538461538462 1.54307002414626 0.0589446546705381 0.315527269118762 GO:0005201 extracellular matrix structural constituent 60/5575 168/18639 0.357142857142857 1.19404228058937 0.0603799701962444 0.321947887960444 GO:0004535 poly(A)-specific ribonuclease activity 7/5575 13/18639 0.538461538461538 1.80024836150397 0.0613909265243073 0.324800832192556 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 7/5575 13/18639 0.538461538461538 1.80024836150397 0.0613909265243073 0.324800832192556 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/5575 29/18639 0.448275862068966 1.49872893149838 0.0636878648937451 0.333306554539745 GO:0097472 cyclin-dependent protein kinase activity 13/5575 29/18639 0.448275862068966 1.49872893149838 0.0636878648937451 0.333306554539745 GO:0002039 p53 binding 27/5575 69/18639 0.391304347826087 1.30825502047183 0.0637311433955117 0.333306554539745 GO:0032182 ubiquitin-like protein binding 44/5575 120/18639 0.366666666666667 1.22588340807175 0.0659472947162978 0.34209765895868 GO:0005123 death receptor binding 10/5575 21/18639 0.476190476190476 1.59205637411915 0.0662409218123497 0.34209765895868 GO:1904047 S-adenosyl-L-methionine binding 10/5575 21/18639 0.476190476190476 1.59205637411915 0.0662409218123497 0.34209765895868 GO:0004843 cysteine-type deubiquitinase activity 40/5575 108/18639 0.37037037037037 1.23826606875934 0.0666315087295532 0.34209765895868 GO:0016407 acetyltransferase activity 36/5575 96/18639 0.375 1.25374439461883 0.0667733754622728 0.34209765895868 GO:0035091 phosphatidylinositol binding 97/5575 284/18639 0.341549295774648 1.14190804016927 0.0669158058182912 0.34209765895868 GO:0015399 primary active transmembrane transporter activity 59/5575 166/18639 0.355421686746988 1.18828785996002 0.0675640781568553 0.34378830329717 GO:0031369 translation initiation factor binding 14/5575 32/18639 0.4375 1.46270179372197 0.0677502224080137 0.34378830329717 GO:0004674 protein serine/threonine kinase activity 144/5575 433/18639 0.33256351039261 1.11186569869199 0.0697115837810637 0.352430784670933 GO:0030295 protein kinase activator activity 50/5575 139/18639 0.359712230215827 1.20263251282382 0.0720093828196351 0.357679359748818 GO:0035035 histone acetyltransferase binding 11/5575 24/18639 0.458333333333333 1.53235426008969 0.0727084558416642 0.357679359748818 GO:0048027 mRNA 5'-UTR binding 11/5575 24/18639 0.458333333333333 1.53235426008969 0.0727084558416642 0.357679359748818 GO:0060229 lipase activator activity 11/5575 24/18639 0.458333333333333 1.53235426008969 0.0727084558416642 0.357679359748818 GO:0000062 fatty-acyl-CoA binding 8/5575 16/18639 0.5 1.67165919282511 0.0731080889156925 0.357679359748818 GO:0004707 MAP kinase activity 8/5575 16/18639 0.5 1.67165919282511 0.0731080889156925 0.357679359748818 GO:0004708 MAP kinase kinase activity 8/5575 16/18639 0.5 1.67165919282511 0.0731080889156925 0.357679359748818 GO:0005521 lamin binding 8/5575 16/18639 0.5 1.67165919282511 0.0731080889156925 0.357679359748818 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 8/5575 16/18639 0.5 1.67165919282511 0.0731080889156925 0.357679359748818 GO:0042826 histone deacetylase binding 46/5575 127/18639 0.362204724409449 1.21096571448748 0.0737325274042804 0.35851124343501 GO:0004536 DNA nuclease activity 25/5575 64/18639 0.390625 1.30598374439462 0.0738034134836906 0.35851124343501 GO:0140034 methylation-dependent protein binding 29/5575 76/18639 0.381578947368421 1.2757399103139 0.0759570754931049 0.363157173651451 GO:0016877 ligase activity, forming carbon-sulfur bonds 17/5575 41/18639 0.414634146341463 1.3862539647818 0.076748799892941 0.363157173651451 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0019107 myristoyltransferase activity 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0032050 clathrin heavy chain binding 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0097493 structural molecule activity conferring elasticity 6/5575 11/18639 0.545454545454545 1.82362821035467 0.0771542713252167 0.363157173651451 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 12/5575 27/18639 0.444444444444444 1.48591928251121 0.0780951390664146 0.366322559538337 GO:0005346 purine ribonucleotide transmembrane transporter activity 9/5575 19/18639 0.473684210526316 1.58367713004484 0.0824352701497272 0.382145604494855 GO:0070003 threonine-type peptidase activity 9/5575 19/18639 0.473684210526316 1.58367713004484 0.0824352701497272 0.382145604494855 GO:0140036 ubiquitin-modified protein reader activity 9/5575 19/18639 0.473684210526316 1.58367713004484 0.0824352701497272 0.382145604494855 GO:0015215 nucleotide transmembrane transporter activity 13/5575 30/18639 0.433333333333333 1.44877130044843 0.0825882441948587 0.382145604494855 GO:0019902 phosphatase binding 66/5575 190/18639 0.347368421052632 1.16136322869955 0.084969777273232 0.391836979655276 GO:0004725 protein tyrosine phosphatase activity 36/5575 98/18639 0.36734693877551 1.22815777432049 0.0872517033684321 0.400535615039781 GO:1990841 promoter-specific chromatin binding 26/5575 68/18639 0.382352941176471 1.27832761804273 0.087442940133227 0.400535615039781 GO:0035064 methylated histone binding 28/5575 74/18639 0.378378378378378 1.26503938916495 0.0880215038025693 0.401837299968251 GO:0055106 ubiquitin-protein transferase regulator activity 15/5575 36/18639 0.416666666666667 1.39304932735426 0.0894697712649085 0.407087459255333 GO:0008649 rRNA methyltransferase activity 10/5575 22/18639 0.454545454545455 1.51969017529556 0.0898996568582785 0.407684490403821 GO:0016758 hexosyltransferase activity 68/5575 197/18639 0.345177664974619 1.15403883362546 0.0910439388970696 0.409405499024425 GO:0004705 JUN kinase activity 7/5575 14/18639 0.5 1.67165919282511 0.0919144128407121 0.409405499024425 GO:0005545 1-phosphatidylinositol binding 7/5575 14/18639 0.5 1.67165919282511 0.0919144128407121 0.409405499024425 GO:0008174 mRNA methyltransferase activity 7/5575 14/18639 0.5 1.67165919282511 0.0919144128407121 0.409405499024425 GO:0098847 sequence-specific single stranded DNA binding 7/5575 14/18639 0.5 1.67165919282511 0.0919144128407121 0.409405499024425 GO:0016776 phosphotransferase activity, phosphate group as acceptor 16/5575 39/18639 0.41025641025641 1.37161779924112 0.0920787459344311 0.409405499024425 GO:1901981 phosphatidylinositol phosphate binding 64/5575 185/18639 0.345945945945946 1.15660744152224 0.0949565731069132 0.420830267178365 GO:0017056 structural constituent of nuclear pore 11/5575 25/18639 0.44 1.4710600896861 0.095904226443106 0.423654592539934 GO:0016504 peptidase activator activity 22/5575 57/18639 0.385964912280702 1.29040358744395 0.100398694517991 0.440772931431738 GO:0051019 mitogen-activated protein kinase binding 12/5575 28/18639 0.428571428571429 1.43285073670724 0.100752417011451 0.440772931431738 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 23/5575 60/18639 0.383333333333333 1.28160538116592 0.100962912741218 0.440772931431738 GO:0002020 protease binding 48/5575 136/18639 0.352941176470588 1.17999472434714 0.101094929956464 0.440772931431738 GO:0003725 double-stranded RNA binding 28/5575 75/18639 0.373333333333333 1.24817219730942 0.101759131096101 0.440772931431738 GO:0140713 histone chaperone activity 57/5575 164/18639 0.347560975609756 1.16200699989063 0.102141575864166 0.440772931431738 GO:0008484 sulfuric ester hydrolase activity 8/5575 17/18639 0.470588235294118 1.57332629912952 0.103008472620311 0.440772931431738 GO:0046965 nuclear retinoid X receptor binding 8/5575 17/18639 0.470588235294118 1.57332629912952 0.103008472620311 0.440772931431738 GO:0048038 quinone binding 8/5575 17/18639 0.470588235294118 1.57332629912952 0.103008472620311 0.440772931431738 GO:1901567 fatty acid derivative binding 8/5575 17/18639 0.470588235294118 1.57332629912952 0.103008472620311 0.440772931431738 GO:0017147 Wnt-protein binding 13/5575 31/18639 0.419354838709677 1.40203674236945 0.104673726913044 0.446498866363453 GO:0015616 DNA translocase activity 53/5575 152/18639 0.348684210526316 1.16576233183856 0.106424623158045 0.45114785903954 GO:0140674 ATP-dependent histone chaperone activity 53/5575 152/18639 0.348684210526316 1.16576233183856 0.106424623158045 0.45114785903954 GO:0000149 SNARE binding 38/5575 106/18639 0.358490566037736 1.19854810051612 0.109986267439151 0.464802647227372 GO:0019213 deacetylase activity 15/5575 37/18639 0.405405405405405 1.35539934553387 0.11039790822293 0.465102298531787 GO:0015095 magnesium ion transmembrane transporter activity 9/5575 20/18639 0.45 1.5044932735426 0.111462248139037 0.466705425490141 GO:0016408 C-acyltransferase activity 9/5575 20/18639 0.45 1.5044932735426 0.111462248139037 0.466705425490141 GO:0004177 aminopeptidase activity 16/5575 40/18639 0.4 1.33732735426009 0.112443124652071 0.467941662042915 GO:0071949 FAD binding 16/5575 40/18639 0.4 1.33732735426009 0.112443124652071 0.467941662042915 GO:0016651 oxidoreductase activity, acting on NAD(P)H 32/5575 88/18639 0.363636363636364 1.21575214023645 0.114552865917636 0.469921921196801 GO:0030291 protein serine/threonine kinase inhibitor activity 18/5575 46/18639 0.391304347826087 1.30825502047183 0.115327723595056 0.469921921196801 GO:0000995 RNA polymerase III general transcription initiation factor activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0004526 ribonuclease P activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0016273 arginine N-methyltransferase activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0016274 protein-arginine N-methyltransferase activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0141221 histone deacetylase activity, hydrolytic mechanism 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:1990247 N6-methyladenosine-containing RNA reader activity 6/5575 12/18639 0.5 1.67165919282511 0.116361618582065 0.469921921196801 GO:0097110 scaffold protein binding 26/5575 70/18639 0.371428571428571 1.24180397181294 0.117545459159773 0.470842723165866 GO:0061980 regulatory RNA binding 22/5575 58/18639 0.379310344827586 1.2681552497294 0.117778986232345 0.470842723165866 GO:0004022 alcohol dehydrogenase (NAD+) activity 10/5575 23/18639 0.434782608695652 1.45361668941314 0.117969385584415 0.470842723165866 GO:0140102 catalytic activity, acting on a rRNA 10/5575 23/18639 0.434782608695652 1.45361668941314 0.117969385584415 0.470842723165866 GO:0019903 protein phosphatase binding 50/5575 144/18639 0.347222222222222 1.16087443946188 0.120855789106212 0.480956711749212 GO:0004529 DNA exonuclease activity 11/5575 26/18639 0.423076923076923 1.4144808554674 0.123007912409656 0.485276879882024 GO:0008198 ferrous iron binding 11/5575 26/18639 0.423076923076923 1.4144808554674 0.123007912409656 0.485276879882024 GO:0015216 purine nucleotide transmembrane transporter activity 11/5575 26/18639 0.423076923076923 1.4144808554674 0.123007912409656 0.485276879882024 GO:0003689 DNA clamp loader activity 55/5575 160/18639 0.34375 1.14926569506726 0.125316992019456 0.492961654485756 GO:0035591 signaling adaptor activity 45/5575 129/18639 0.348837209302326 1.16627385545938 0.12750955744653 0.494519746492247 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0031386 protein tag activity 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0050780 dopamine receptor binding 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0140776 protein-containing complex destabilizing activity 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0141047 molecular tag activity 7/5575 15/18639 0.466666666666667 1.56021524663677 0.129361609160619 0.494519746492247 GO:0000510 H3-H4 histone complex chaperone activity 52/5575 151/18639 0.344370860927152 1.15134143081994 0.129698219226538 0.494519746492247 GO:0140584 chromatin extrusion motor activity 52/5575 151/18639 0.344370860927152 1.15134143081994 0.129698219226538 0.494519746492247 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 52/5575 151/18639 0.344370860927152 1.15134143081994 0.129698219226538 0.494519746492247 GO:0140849 ATP-dependent H2AZ histone chaperone activity 52/5575 151/18639 0.344370860927152 1.15134143081994 0.129698219226538 0.494519746492247 GO:0003724 RNA helicase activity 28/5575 77/18639 0.363636363636364 1.21575214023645 0.133179173387818 0.506377636975965 GO:0140857 histone H3T45 kinase activity 82/5575 246/18639 0.333333333333333 1.11443946188341 0.133841760198399 0.507483340752262 GO:0008137 NADH dehydrogenase (ubiquinone) activity 16/5575 41/18639 0.390243902439024 1.30470961391228 0.135287492497914 0.510720100653876 GO:0001046 core promoter sequence-specific DNA binding 17/5575 44/18639 0.386363636363636 1.29173664900122 0.136192026841033 0.510720100653876 GO:0001223 transcription coactivator binding 17/5575 44/18639 0.386363636363636 1.29173664900122 0.136192026841033 0.510720100653876 GO:0019205 nucleobase-containing compound kinase activity 17/5575 44/18639 0.386363636363636 1.29173664900122 0.136192026841033 0.510720100653876 GO:0031593 polyubiquitin modification-dependent protein binding 22/5575 59/18639 0.372881355932203 1.24666109295432 0.136881564929221 0.511899551036675 GO:0016854 racemase and epimerase activity 8/5575 18/18639 0.444444444444444 1.48591928251121 0.138643429432064 0.514261633627085 GO:0070064 proline-rich region binding 8/5575 18/18639 0.444444444444444 1.48591928251121 0.138643429432064 0.514261633627085 GO:1990381 ubiquitin-specific protease binding 8/5575 18/18639 0.444444444444444 1.48591928251121 0.138643429432064 0.514261633627085 GO:0004519 endonuclease activity 44/5575 127/18639 0.346456692913386 1.1583150312489 0.142140552206208 0.519589785838668 GO:0035403 histone H3T6 kinase activity 82/5575 247/18639 0.331983805668016 1.10992756122801 0.143400527918747 0.519589785838668 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 9/5575 21/18639 0.428571428571429 1.43285073670724 0.145378242884053 0.519589785838668 GO:0072542 protein phosphatase activator activity 9/5575 21/18639 0.428571428571429 1.43285073670724 0.145378242884053 0.519589785838668 GO:0022853 active monoatomic ion transmembrane transporter activity 41/5575 118/18639 0.347457627118644 1.16166147298016 0.147085851494396 0.519589785838668 GO:0005381 iron ion transmembrane transporter activity 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0005522 profilin binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0015279 store-operated calcium channel activity 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0016868 intramolecular phosphotransferase activity 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0043295 glutathione binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0051880 G-quadruplex DNA binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0097177 mitochondrial ribosome binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0098505 G-rich strand telomeric DNA binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:1905394 retromer complex binding 5/5575 10/18639 0.5 1.67165919282511 0.148675844496482 0.519589785838668 GO:0016829 lyase activity 67/5575 200/18639 0.335 1.12001165919283 0.149977562028891 0.519589785838668 GO:0001091 RNA polymerase II general transcription initiation factor binding 10/5575 24/18639 0.416666666666667 1.39304932735426 0.150298621114951 0.519589785838668 GO:0042625 ATPase-coupled ion transmembrane transporter activity 10/5575 24/18639 0.416666666666667 1.39304932735426 0.150298621114951 0.519589785838668 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 10/5575 24/18639 0.416666666666667 1.39304932735426 0.150298621114951 0.519589785838668 GO:0046961 proton-transporting ATPase activity, rotational mechanism 10/5575 24/18639 0.416666666666667 1.39304932735426 0.150298621114951 0.519589785838668 GO:0140612 DNA damage sensor activity 10/5575 24/18639 0.416666666666667 1.39304932735426 0.150298621114951 0.519589785838668 GO:0005518 collagen binding 26/5575 72/18639 0.361111111111111 1.20730941704036 0.153349454625846 0.519589785838668 GO:0004679 AMP-activated protein kinase activity 82/5575 248/18639 0.330645161290323 1.10545204686822 0.153375641696515 0.519589785838668 GO:0061775 cohesin loader activity 52/5575 153/18639 0.339869281045752 1.13629121603798 0.15457256922079 0.519589785838668 GO:0004676 3-phosphoinositide-dependent protein kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0004711 ribosomal protein S6 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0035175 histone H3S10 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0035979 histone H2AXS139 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0044022 histone H3S28 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0044023 histone H4S1 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0044024 histone H2AS1 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0044025 histone H2BS14 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0072354 histone H3T3 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0072371 histone H2AS121 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0072518 Rho-dependent protein serine/threonine kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0140823 histone H2BS36 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0140855 histone H3S57 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0140995 histone H2A kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0140997 histone H4 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0140998 histone H2B kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:1990244 histone H2AT120 kinase activity 81/5575 245/18639 0.330612244897959 1.10534199688844 0.155305957964964 0.519589785838668 GO:0019239 deaminase activity 13/5575 33/18639 0.393939393939394 1.31706481858948 0.158275906756518 0.525660858205954 GO:0071889 14-3-3 protein binding 13/5575 33/18639 0.393939393939394 1.31706481858948 0.158275906756518 0.525660858205954 GO:0140311 protein sequestering activity 13/5575 33/18639 0.393939393939394 1.31706481858948 0.158275906756518 0.525660858205954 GO:0050661 NADP binding 20/5575 54/18639 0.37037037037037 1.23826606875934 0.159299955821656 0.526783931351057 GO:0015078 proton transmembrane transporter activity 62/5575 185/18639 0.335135135135135 1.12046345897467 0.159799016670305 0.526783931351057 GO:0016830 carbon-carbon lyase activity 19/5575 51/18639 0.372549019607843 1.24554998681087 0.159908703930136 0.526783931351057 GO:0048487 beta-tubulin binding 16/5575 42/18639 0.380952380952381 1.27364509929532 0.160543674316513 0.526783931351057 GO:0051879 Hsp90 protein binding 16/5575 42/18639 0.380952380952381 1.27364509929532 0.160543674316513 0.526783931351057 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/5575 13/18639 0.461538461538462 1.54307002414626 0.163479354631571 0.531307902552607 GO:0035673 oligopeptide transmembrane transporter activity 6/5575 13/18639 0.461538461538462 1.54307002414626 0.163479354631571 0.531307902552607 GO:0046975 histone H3K36 methyltransferase activity 6/5575 13/18639 0.461538461538462 1.54307002414626 0.163479354631571 0.531307902552607 GO:0140852 histone ubiquitin ligase activity 6/5575 13/18639 0.461538461538462 1.54307002414626 0.163479354631571 0.531307902552607 GO:0004197 cysteine-type endopeptidase activity 31/5575 88/18639 0.352272727272727 1.17775988585406 0.16446329720736 0.533236106147378 GO:0004677 DNA-dependent protein kinase activity 81/5575 246/18639 0.329268292682927 1.10084873673849 0.165842927777643 0.536435062598299 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 80/5575 243/18639 0.329218106995885 1.1006809500083 0.167954386134589 0.541980465895304 GO:0008186 ATP-dependent activity, acting on RNA 28/5575 79/18639 0.354430379746835 1.18497360504059 0.169807731472877 0.545382478730536 GO:0046332 SMAD binding 28/5575 79/18639 0.354430379746835 1.18497360504059 0.169807731472877 0.545382478730536 GO:0008142 oxysterol binding 7/5575 16/18639 0.4375 1.46270179372197 0.173114347128895 0.550243747952036 GO:0031435 mitogen-activated protein kinase kinase kinase binding 7/5575 16/18639 0.4375 1.46270179372197 0.173114347128895 0.550243747952036 GO:0070411 I-SMAD binding 7/5575 16/18639 0.4375 1.46270179372197 0.173114347128895 0.550243747952036 GO:0097027 ubiquitin-protein transferase activator activity 7/5575 16/18639 0.4375 1.46270179372197 0.173114347128895 0.550243747952036 GO:0004521 RNA endonuclease activity 26/5575 73/18639 0.356164383561644 1.19077093187542 0.173336858329213 0.550243747952036 GO:0035402 histone H3T11 kinase activity 81/5575 247/18639 0.327935222672065 1.09639185926181 0.176793737347344 0.558619100646123 GO:0042393 histone binding 81/5575 247/18639 0.327935222672065 1.09639185926181 0.176793737347344 0.558619100646123 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 8/5575 19/18639 0.421052631578947 1.4077130044843 0.179522090728308 0.565132242035232 GO:0140658 ATP-dependent chromatin remodeler activity 53/5575 158/18639 0.335443037974684 1.12149287619913 0.179683071826587 0.565132242035232 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 31/5575 89/18639 0.348314606741573 1.16452662870963 0.183167312023318 0.570155830297931 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 31/5575 89/18639 0.348314606741573 1.16452662870963 0.183167312023318 0.570155830297931 GO:0004407 histone deacetylase activity 9/5575 22/18639 0.409090909090909 1.367721157766 0.183786494748051 0.570155830297931 GO:0033558 protein lysine deacetylase activity 9/5575 22/18639 0.409090909090909 1.367721157766 0.183786494748051 0.570155830297931 GO:0050321 tau-protein kinase activity 9/5575 22/18639 0.409090909090909 1.367721157766 0.183786494748051 0.570155830297931 GO:0070034 telomerase RNA binding 9/5575 22/18639 0.409090909090909 1.367721157766 0.183786494748051 0.570155830297931 GO:0005080 protein kinase C binding 19/5575 52/18639 0.365384615384615 1.22159710244912 0.184616313273905 0.571383973905583 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 10/5575 25/18639 0.4 1.33732735426009 0.18656155089618 0.571383973905583 GO:0017025 TBP-class protein binding 10/5575 25/18639 0.4 1.33732735426009 0.18656155089618 0.571383973905583 GO:0019211 phosphatase activator activity 10/5575 25/18639 0.4 1.33732735426009 0.18656155089618 0.571383973905583 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 10/5575 25/18639 0.4 1.33732735426009 0.18656155089618 0.571383973905583 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 44/5575 130/18639 0.338461538461538 1.13158468437392 0.186693957774278 0.571383973905583 GO:0004712 protein serine/threonine/tyrosine kinase activity 16/5575 43/18639 0.372093023255814 1.24402544582334 0.188087312655507 0.572344311729391 GO:0048156 tau protein binding 16/5575 43/18639 0.372093023255814 1.24402544582334 0.188087312655507 0.572344311729391 GO:0019789 SUMO transferase activity 11/5575 28/18639 0.392857142857143 1.3134465086483 0.188265638070694 0.572344311729391 GO:0005548 phospholipid transporter activity 24/5575 68/18639 0.352941176470588 1.17999472434714 0.199357495948124 0.604717737709309 GO:0140793 histone H2AXY142 phosphatase activity 31/5575 90/18639 0.344444444444444 1.15158744394619 0.20294942457846 0.614248258424829 GO:0010854 adenylate cyclase regulator activity 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0034511 U3 snoRNA binding 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0034713 type I transforming growth factor beta receptor binding 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0035252 UDP-xylosyltransferase activity 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0042285 xylosyltransferase activity 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0045294 alpha-catenin binding 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:1900750 oligopeptide binding 5/5575 11/18639 0.454545454545455 1.51969017529556 0.208277155472536 0.616052345614222 GO:0051117 ATPase binding 29/5575 84/18639 0.345238095238095 1.15424087123639 0.208510024669429 0.616052345614222 GO:0051018 protein kinase A binding 19/5575 53/18639 0.358490566037736 1.19854810051612 0.211108853257021 0.619706633754482 GO:0140296 general transcription initiation factor binding 19/5575 53/18639 0.358490566037736 1.19854810051612 0.211108853257021 0.619706633754482 GO:1901505 carbohydrate derivative transmembrane transporter activity 19/5575 53/18639 0.358490566037736 1.19854810051612 0.211108853257021 0.619706633754482 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 41/5575 122/18639 0.336065573770492 1.12357421157098 0.211819719186629 0.620112820565872 GO:0043130 ubiquitin binding 34/5575 100/18639 0.34 1.13672825112108 0.214316179325616 0.620112820565872 GO:0140359 ABC-type transporter activity 17/5575 47/18639 0.361702127659574 1.20928537353306 0.21560425776222 0.620112820565872 GO:0140938 histone H3 methyltransferase activity 17/5575 47/18639 0.361702127659574 1.20928537353306 0.21560425776222 0.620112820565872 GO:0004065 arylsulfatase activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0005161 platelet-derived growth factor receptor binding 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0005347 ATP transmembrane transporter activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0008191 metalloendopeptidase inhibitor activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0008331 high voltage-gated calcium channel activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0042813 Wnt receptor activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0061665 SUMO ligase activity 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0071933 Arp2/3 complex binding 6/5575 14/18639 0.428571428571429 1.43285073670724 0.217153060974716 0.620112820565872 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 44/5575 132/18639 0.333333333333333 1.11443946188341 0.22015486596044 0.622733295982061 GO:0042162 telomeric DNA binding 14/5575 38/18639 0.368421052631579 1.23174887892377 0.221645523716966 0.622733295982061 GO:0042887 amide transmembrane transporter activity 14/5575 38/18639 0.368421052631579 1.23174887892377 0.221645523716966 0.622733295982061 GO:0016805 dipeptidase activity 7/5575 17/18639 0.411764705882353 1.37666051173833 0.222188459284904 0.622733295982061 GO:0017110 nucleoside diphosphate phosphatase activity 7/5575 17/18639 0.411764705882353 1.37666051173833 0.222188459284904 0.622733295982061 GO:0070403 NAD+ binding 7/5575 17/18639 0.411764705882353 1.37666051173833 0.222188459284904 0.622733295982061 GO:0043015 gamma-tubulin binding 13/5575 35/18639 0.371428571428571 1.24180397181294 0.223320824657238 0.622733295982061 GO:0008378 galactosyltransferase activity 12/5575 32/18639 0.375 1.25374439461883 0.224723935913072 0.622733295982061 GO:0000339 RNA cap binding 8/5575 20/18639 0.4 1.33732735426009 0.224895319121155 0.622733295982061 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 8/5575 20/18639 0.4 1.33732735426009 0.224895319121155 0.622733295982061 GO:0052745 inositol phosphate phosphatase activity 8/5575 20/18639 0.4 1.33732735426009 0.224895319121155 0.622733295982061 GO:0140664 ATP-dependent DNA damage sensor activity 8/5575 20/18639 0.4 1.33732735426009 0.224895319121155 0.622733295982061 GO:0140939 histone H4 methyltransferase activity 8/5575 20/18639 0.4 1.33732735426009 0.224895319121155 0.622733295982061 GO:0000295 adenine nucleotide transmembrane transporter activity 9/5575 23/18639 0.391304347826087 1.30825502047183 0.226097493496103 0.622733295982061 GO:0042171 lysophosphatidic acid acyltransferase activity 9/5575 23/18639 0.391304347826087 1.30825502047183 0.226097493496103 0.622733295982061 GO:0071617 lysophospholipid acyltransferase activity 9/5575 23/18639 0.391304347826087 1.30825502047183 0.226097493496103 0.622733295982061 GO:0034237 protein kinase A regulatory subunit binding 10/5575 26/18639 0.384615384615385 1.28589168678855 0.226282574950258 0.622733295982061 GO:0052742 phosphatidylinositol kinase activity 10/5575 26/18639 0.384615384615385 1.28589168678855 0.226282574950258 0.622733295982061 GO:0005096 GTPase activator activity 87/5575 271/18639 0.321033210332103 1.07331623450764 0.232257294096313 0.637889751391281 GO:0015932 nucleobase-containing compound transmembrane transporter activity 20/5575 57/18639 0.350877192982456 1.17309417040359 0.235950364945041 0.646731421987913 GO:0001217 DNA-binding transcription repressor activity 89/5575 278/18639 0.320143884892086 1.0703429364132 0.238794057266364 0.653107955390879 GO:0017069 snRNA binding 19/5575 54/18639 0.351851851851852 1.17635276532138 0.239233683293362 0.653107955390879 GO:0060589 nucleoside-triphosphatase regulator activity 154/5575 490/18639 0.314285714285714 1.05075720691864 0.242881396578954 0.661742727206132 GO:0016879 ligase activity, forming carbon-nitrogen bonds 17/5575 48/18639 0.354166666666667 1.18409192825112 0.245907911780232 0.668653983227124 GO:0045296 cadherin binding 106/5575 334/18639 0.317365269461078 1.06105314035606 0.248447264242403 0.67421573696 GO:0004520 DNA endonuclease activity 15/5575 42/18639 0.357142857142857 1.19404228058937 0.252671199890303 0.684317833036237 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 12/5575 33/18639 0.363636363636364 1.21575214023645 0.262694238288247 0.706011537300778 GO:0030695 GTPase regulator activity 153/5575 489/18639 0.312883435582822 1.04606894274946 0.264943545970769 0.706011537300778 GO:0140313 molecular sequestering activity 19/5575 55/18639 0.345454545454545 1.15496453322462 0.268809019091868 0.706011537300778 GO:0004364 glutathione transferase activity 10/5575 27/18639 0.37037037037037 1.23826606875934 0.268869122519155 0.706011537300778 GO:0004622 lysophospholipase activity 9/5575 24/18639 0.375 1.25374439461883 0.271576816924795 0.706011537300778 GO:0005540 hyaluronic acid binding 9/5575 24/18639 0.375 1.25374439461883 0.271576816924795 0.706011537300778 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 18/5575 52/18639 0.346153846153846 1.15730251810969 0.273228305475845 0.706011537300778 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 8/5575 21/18639 0.380952380952381 1.27364509929532 0.273828904497833 0.706011537300778 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/5575 21/18639 0.380952380952381 1.27364509929532 0.273828904497833 0.706011537300778 GO:0035613 RNA stem-loop binding 8/5575 21/18639 0.380952380952381 1.27364509929532 0.273828904497833 0.706011537300778 GO:0051010 microtubule plus-end binding 8/5575 21/18639 0.380952380952381 1.27364509929532 0.273828904497833 0.706011537300778 GO:0000340 RNA 7-methylguanosine cap binding 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0003995 acyl-CoA dehydrogenase activity 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0005078 MAP-kinase scaffold activity 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0031543 peptidyl-proline dioxygenase activity 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0034452 dynactin binding 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0035259 nuclear glucocorticoid receptor binding 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0070679 inositol 1,4,5 trisphosphate binding 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:1990459 transferrin receptor binding 5/5575 12/18639 0.416666666666667 1.39304932735426 0.273931110394301 0.706011537300778 GO:0000400 four-way junction DNA binding 7/5575 18/18639 0.388888888888889 1.30017937219731 0.275353478282166 0.706011537300778 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 7/5575 18/18639 0.388888888888889 1.30017937219731 0.275353478282166 0.706011537300778 GO:0017128 phospholipid scramblase activity 7/5575 18/18639 0.388888888888889 1.30017937219731 0.275353478282166 0.706011537300778 GO:0031690 adrenergic receptor binding 7/5575 18/18639 0.388888888888889 1.30017937219731 0.275353478282166 0.706011537300778 GO:0070628 proteasome binding 7/5575 18/18639 0.388888888888889 1.30017937219731 0.275353478282166 0.706011537300778 GO:0061578 K63-linked deubiquitinase activity 6/5575 15/18639 0.4 1.33732735426009 0.275680695517447 0.706011537300778 GO:0141050 histone H3K deacetylase activity 6/5575 15/18639 0.4 1.33732735426009 0.275680695517447 0.706011537300778 GO:0141051 histone H4K deacetylase activity 6/5575 15/18639 0.4 1.33732735426009 0.275680695517447 0.706011537300778 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 85/5575 268/18639 0.317164179104478 1.06038083126966 0.277966918571058 0.710533415448491 GO:0030971 receptor tyrosine kinase binding 27/5575 81/18639 0.333333333333333 1.11443946188341 0.286522095361842 0.731033009661523 GO:0004386 helicase activity 50/5575 155/18639 0.32258064516129 1.07848980182265 0.287461147930051 0.732060572620372 GO:0016831 carboxy-lyase activity 12/5575 34/18639 0.352941176470588 1.17999472434714 0.302620605095679 0.766376857060487 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 12/5575 34/18639 0.352941176470588 1.17999472434714 0.302620605095679 0.766376857060487 GO:0030332 cyclin binding 12/5575 34/18639 0.352941176470588 1.17999472434714 0.302620605095679 0.766376857060487 GO:0008080 N-acetyltransferase activity 23/5575 69/18639 0.333333333333333 1.11443946188341 0.307359859911162 0.776937423664325 GO:0042626 ATPase-coupled transmembrane transporter activity 32/5575 98/18639 0.326530612244898 1.09169579939599 0.310336958198348 0.78301284277402 GO:0046625 sphingolipid binding 10/5575 28/18639 0.357142857142857 1.19404228058937 0.313648836101633 0.788454256498581 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 10/5575 28/18639 0.357142857142857 1.19404228058937 0.313648836101633 0.788454256498581 GO:0008483 transaminase activity 9/5575 25/18639 0.36 1.20359461883408 0.31939790406589 0.799959888165028 GO:0047617 fatty acyl-CoA hydrolase activity 9/5575 25/18639 0.36 1.20359461883408 0.31939790406589 0.799959888165028 GO:0016248 channel inhibitor activity 15/5575 44/18639 0.340909090909091 1.13976763147167 0.323232443262356 0.808081108155889 GO:0098531 ligand-modulated transcription factor activity 20/5575 60/18639 0.333333333333333 1.11443946188341 0.325073594951681 0.811198276250537 GO:0008238 exopeptidase activity 33/5575 102/18639 0.323529411764706 1.08166183065154 0.328792401626436 0.814734298295154 GO:0097001 ceramide binding 7/5575 19/18639 0.368421052631579 1.23174887892377 0.331255121021917 0.814734298295154 GO:1990380 K48-linked deubiquitinase activity 7/5575 19/18639 0.368421052631579 1.23174887892377 0.331255121021917 0.814734298295154 GO:0005109 frizzled binding 13/5575 38/18639 0.342105263157895 1.1437668161435 0.336713374438099 0.814734298295154 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0008296 3'-5'-DNA exonuclease activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0015562 efflux transmembrane transporter activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0022858 alanine transmembrane transporter activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0034450 ubiquitin-ubiquitin ligase activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0140327 flippase activity 6/5575 16/18639 0.375 1.25374439461883 0.337220504550578 0.814734298295154 GO:0008417 fucosyltransferase activity 5/5575 13/18639 0.384615384615385 1.28589168678855 0.342963457746007 0.814734298295154 GO:0017154 semaphorin receptor activity 5/5575 13/18639 0.384615384615385 1.28589168678855 0.342963457746007 0.814734298295154 GO:0031994 insulin-like growth factor I binding 5/5575 13/18639 0.384615384615385 1.28589168678855 0.342963457746007 0.814734298295154 GO:0016229 steroid dehydrogenase activity 12/5575 35/18639 0.342857142857143 1.14628058936579 0.343994403585301 0.814734298295154 GO:0004382 GDP phosphatase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0008140 cAMP response element binding protein binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0008239 dipeptidyl-peptidase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0032052 bile acid binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0032356 oxidized DNA binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0035256 G protein-coupled glutamate receptor binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0043422 protein kinase B binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0050815 phosphoserine residue binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0051864 histone H3K36 demethylase activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0070513 death domain binding 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 4/5575 10/18639 0.4 1.33732735426009 0.347978092238883 0.814734298295154 GO:0043425 bHLH transcription factor binding 11/5575 32/18639 0.34375 1.14926569506726 0.35170334214867 0.822046339097491 GO:0016836 hydro-lyase activity 20/5575 61/18639 0.327868852459016 1.09616996250827 0.356657957900682 0.832201901768259 GO:0016417 S-acyltransferase activity 10/5575 29/18639 0.344827586206897 1.15286840884491 0.359907534311002 0.83619402676169 GO:0140303 intramembrane lipid transporter activity 15/5575 45/18639 0.333333333333333 1.11443946188341 0.360206657681959 0.83619402676169 GO:0141110 transporter inhibitor activity 15/5575 45/18639 0.333333333333333 1.11443946188341 0.360206657681959 0.83619402676169 GO:0005112 Notch binding 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0005160 transforming growth factor beta receptor binding 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0008157 protein phosphatase 1 binding 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0016289 acyl-CoA hydrolase activity 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0050681 nuclear androgen receptor binding 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0070412 R-SMAD binding 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0120014 phospholipid transfer activity 9/5575 26/18639 0.346153846153846 1.15730251810969 0.368694254774166 0.845827996246617 GO:0019888 protein phosphatase regulator activity 34/5575 107/18639 0.317757009345794 1.06236285151502 0.371017571721205 0.849729841274236 GO:0008374 O-acyltransferase activity 18/5575 55/18639 0.327272727272727 1.0941769262128 0.371878004948816 0.85027383041061 GO:0032934 sterol binding 22/5575 68/18639 0.323529411764706 1.08166183065154 0.37307437329163 0.851582808600459 GO:0019208 phosphatase regulator activity 37/5575 117/18639 0.316239316239316 1.05728872024836 0.375706215485656 0.856158571181837 GO:0003887 DNA-directed DNA polymerase activity 8/5575 23/18639 0.347826086956522 1.16289335153051 0.378179958908089 0.860359406515902 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 29/5575 91/18639 0.318681318681319 1.06545311191051 0.379110796483283 0.861041992012781 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 7/5575 20/18639 0.35 1.17016143497758 0.388525783583865 0.878042540715192 GO:0016505 peptidase activator activity involved in apoptotic process 7/5575 20/18639 0.35 1.17016143497758 0.388525783583865 0.878042540715192 GO:0031418 L-ascorbic acid binding 7/5575 20/18639 0.35 1.17016143497758 0.388525783583865 0.878042540715192 GO:0004879 nuclear receptor activity 19/5575 59/18639 0.322033898305085 1.076661853006 0.397244944388955 0.892079371145692 GO:0030276 clathrin binding 15/5575 46/18639 0.326086956521739 1.09021251705986 0.397829765350284 0.892079371145692 GO:0005085 guanyl-nucleotide exchange factor activity 71/5575 230/18639 0.308695652173913 1.03206784948333 0.398963389038215 0.892079371145692 GO:0004550 nucleoside diphosphate kinase activity 6/5575 17/18639 0.352941176470588 1.17999472434714 0.399965256513673 0.892079371145692 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/5575 17/18639 0.352941176470588 1.17999472434714 0.399965256513673 0.892079371145692 GO:0016018 cyclosporin A binding 6/5575 17/18639 0.352941176470588 1.17999472434714 0.399965256513673 0.892079371145692 GO:0031489 myosin V binding 6/5575 17/18639 0.352941176470588 1.17999472434714 0.399965256513673 0.892079371145692 GO:1990226 histone methyltransferase binding 6/5575 17/18639 0.352941176470588 1.17999472434714 0.399965256513673 0.892079371145692 GO:0008237 metallopeptidase activity 57/5575 184/18639 0.309782608695652 1.03570189120686 0.402468620141272 0.896198477149815 GO:0052689 carboxylic ester hydrolase activity 29/5575 92/18639 0.315217391304348 1.05387209982453 0.405755110048078 0.898670995509009 GO:0008106 alcohol dehydrogenase (NADP+) activity 10/5575 30/18639 0.333333333333333 1.11443946188341 0.406924989512762 0.898670995509009 GO:0016769 transferase activity, transferring nitrogenous groups 10/5575 30/18639 0.333333333333333 1.11443946188341 0.406924989512762 0.898670995509009 GO:0051721 protein phosphatase 2A binding 10/5575 30/18639 0.333333333333333 1.11443946188341 0.406924989512762 0.898670995509009 GO:0008200 ion channel inhibitor activity 14/5575 43/18639 0.325581395348837 1.08852226509542 0.407529191370019 0.898670995509009 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 14/5575 43/18639 0.325581395348837 1.08852226509542 0.407529191370019 0.898670995509009 GO:0008235 metalloexopeptidase activity 21/5575 66/18639 0.318181818181818 1.06378312270689 0.412375699991605 0.902743712250848 GO:0008559 ABC-type xenobiotic transporter activity 5/5575 14/18639 0.357142857142857 1.19404228058937 0.412858122618947 0.902743712250848 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 5/5575 14/18639 0.357142857142857 1.19404228058937 0.412858122618947 0.902743712250848 GO:0046030 inositol trisphosphate phosphatase activity 5/5575 14/18639 0.357142857142857 1.19404228058937 0.412858122618947 0.902743712250848 GO:0070742 C2H2 zinc finger domain binding 5/5575 14/18639 0.357142857142857 1.19404228058937 0.412858122618947 0.902743712250848 GO:0035173 histone kinase activity 110/5575 360/18639 0.305555555555556 1.02156950672646 0.413344190591048 0.902743712250848 GO:0034212 protein N-acetyltransferase activity 17/5575 53/18639 0.320754716981132 1.07238514256705 0.415430374905726 0.905850577869515 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 9/5575 27/18639 0.333333333333333 1.11443946188341 0.418606820901672 0.911321069427086 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0008526 phosphatidylinositol transfer activity 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0015173 aromatic amino acid transmembrane transporter activity 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0015217 ADP transmembrane transporter activity 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0019215 intermediate filament binding 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0034056 estrogen response element binding 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0043522 leucine zipper domain binding 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0047676 arachidonate-CoA ligase activity 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0140031 phosphorylation-dependent protein binding 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:1990948 ubiquitin ligase inhibitor activity 4/5575 11/18639 0.363636363636364 1.21575214023645 0.42780719896251 0.915292831636091 GO:0042805 actinin binding 12/5575 37/18639 0.324324324324324 1.0843194764271 0.428980923054366 0.916367699482332 GO:0015295 solute:proton symporter activity 8/5575 24/18639 0.333333333333333 1.11443946188341 0.431481529899736 0.918833523109422 GO:0050431 transforming growth factor beta binding 8/5575 24/18639 0.333333333333333 1.11443946188341 0.431481529899736 0.918833523109422 GO:0051219 phosphoprotein binding 29/5575 93/18639 0.311827956989247 1.0425401417619 0.432603328678739 0.919787451162739 GO:0044325 transmembrane transporter binding 42/5575 136/18639 0.308823529411765 1.03249538380375 0.433872575021297 0.921051422867917 GO:0043495 protein-membrane adaptor activity 15/5575 47/18639 0.319148936170213 1.06701650605858 0.435740084864178 0.922147621456749 GO:0061733 protein-lysine-acetyltransferase activity 15/5575 47/18639 0.319148936170213 1.06701650605858 0.435740084864178 0.922147621456749 GO:0090482 vitamin transmembrane transporter activity 11/5575 34/18639 0.323529411764706 1.08166183065154 0.440967032288239 0.931764704448059 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 21/5575 67/18639 0.313432835820896 1.04790576266649 0.44416371276014 0.934897564620881 GO:0004222 metalloendopeptidase activity 34/5575 110/18639 0.309090909090909 1.03338931920098 0.444895337553466 0.934897564620881 GO:0001846 opsonin binding 7/5575 21/18639 0.333333333333333 1.11443946188341 0.445874223126882 0.934897564620881 GO:0009975 cyclase activity 7/5575 21/18639 0.333333333333333 1.11443946188341 0.445874223126882 0.934897564620881 GO:0070182 DNA polymerase binding 7/5575 21/18639 0.333333333333333 1.11443946188341 0.445874223126882 0.934897564620881 GO:0016878 acid-thiol ligase activity 10/5575 31/18639 0.32258064516129 1.07848980182265 0.454006331540179 0.949033143265459 GO:0072349 modified amino acid transmembrane transporter activity 10/5575 31/18639 0.32258064516129 1.07848980182265 0.454006331540179 0.949033143265459 GO:0004812 aminoacyl-tRNA ligase activity 13/5575 41/18639 0.317073170731707 1.06007656130373 0.458768923762688 0.956060428910029 GO:0016875 ligase activity, forming carbon-oxygen bonds 13/5575 41/18639 0.317073170731707 1.06007656130373 0.458768923762688 0.956060428910029 GO:0016410 N-acyltransferase activity 29/5575 94/18639 0.308510638297872 1.03144928918996 0.459529720705607 0.956186080431636 GO:0000900 mRNA regulatory element binding translation repressor activity 6/5575 18/18639 0.333333333333333 1.11443946188341 0.462271145629426 0.95896673827381 GO:1901611 phosphatidylglycerol binding 6/5575 18/18639 0.333333333333333 1.11443946188341 0.462271145629426 0.95896673827381 GO:0140996 histone H3 kinase activity 108/5575 357/18639 0.302521008403361 1.0114240494404 0.46355959591684 0.960010666965013 GO:0019905 syntaxin binding 19/5575 61/18639 0.311475409836066 1.04136146438286 0.464180981829237 0.960010666965013 GO:0140299 molecular sensor activity 22/5575 71/18639 0.309859154929577 1.0359578096381 0.465866755072348 0.96203951690432 GO:0141003 histone H2AX kinase activity 107/5575 354/18639 0.30225988700565 1.01055103747055 0.468184714461217 0.964195978673759 GO:0051393 alpha-actinin binding 9/5575 28/18639 0.321428571428571 1.07463805253043 0.468323761070111 0.964195978673759 GO:0004129 cytochrome-c oxidase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0015929 hexosaminidase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0016846 carbon-sulfur lyase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0042809 nuclear vitamin D receptor binding 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0048531 beta-1,3-galactosyltransferase activity 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:0051371 muscle alpha-actinin binding 5/5575 15/18639 0.333333333333333 1.11443946188341 0.481446836169698 0.979396320971143 GO:1901681 sulfur compound binding 83/5575 275/18639 0.301818181818182 1.00907427639625 0.483523811573828 0.980666965912808 GO:0004709 MAP kinase kinase kinase activity 8/5575 25/18639 0.32 1.06986188340807 0.484226765586251 0.980666965912808 GO:0042974 nuclear retinoic acid receptor binding 8/5575 25/18639 0.32 1.06986188340807 0.484226765586251 0.980666965912808 GO:0004402 histone acetyltransferase activity 13/5575 42/18639 0.30952380952381 1.03483664317745 0.499290363900152 0.999966991337631 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 10/5575 32/18639 0.3125 1.04478699551569 0.500507690354502 0.999966991337631 GO:0008093 cytoskeletal anchor activity 7/5575 22/18639 0.318181818181818 1.06378312270689 0.502150729220495 0.999966991337631 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/5575 22/18639 0.318181818181818 1.06378312270689 0.502150729220495 0.999966991337631 GO:0061133 endopeptidase activator activity 7/5575 22/18639 0.318181818181818 1.06378312270689 0.502150729220495 0.999966991337631 GO:0004126 cytidine deaminase activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0004859 phospholipase inhibitor activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0005095 GTPase inhibitor activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0005247 voltage-gated chloride channel activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0016801 hydrolase activity, acting on ether bonds 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0016803 ether hydrolase activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0016840 carbon-nitrogen lyase activity 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0035197 siRNA binding 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0035497 cAMP response element binding 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0097677 STAT family protein binding 4/5575 12/18639 0.333333333333333 1.11443946188341 0.504745243246614 0.999966991337631 GO:0016835 carbon-oxygen lyase activity 24/5575 79/18639 0.30379746835443 1.01569166146336 0.506116186542531 1 GO:0045309 protein phosphorylated amino acid binding 18/5575 59/18639 0.305084745762712 1.0199954396899 0.509070195679776 1 GO:0070888 E-box binding 18/5575 59/18639 0.305084745762712 1.0199954396899 0.509070195679776 1 GO:0008013 beta-catenin binding 32/5575 106/18639 0.30188679245283 1.00930366359252 0.511745050707154 1 GO:0035250 UDP-galactosyltransferase activity 9/5575 29/18639 0.310344827586207 1.03758156796041 0.517111063111711 1 GO:0106222 lncRNA binding 9/5575 29/18639 0.310344827586207 1.03758156796041 0.517111063111711 1 GO:0005520 insulin-like growth factor binding 6/5575 19/18639 0.315789473684211 1.05578475336323 0.522740080063662 1 GO:0042800 histone H3K4 methyltransferase activity 6/5575 19/18639 0.315789473684211 1.05578475336323 0.522740080063662 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 39/5575 130/18639 0.3 1.00299551569507 0.524315122379939 1 GO:0030165 PDZ domain binding 25/5575 83/18639 0.301204819277108 1.00702361013561 0.524792911932318 1 GO:0004033 aldo-keto reductase (NADPH) activity 11/5575 36/18639 0.305555555555556 1.02156950672646 0.529027221033253 1 GO:0016409 palmitoyltransferase activity 11/5575 36/18639 0.305555555555556 1.02156950672646 0.529027221033253 1 GO:0045505 dynein intermediate chain binding 11/5575 36/18639 0.305555555555556 1.02156950672646 0.529027221033253 1 GO:0005507 copper ion binding 19/5575 63/18639 0.301587301587302 1.00830237027546 0.530373300963139 1 GO:0005246 calcium channel regulator activity 16/5575 53/18639 0.30188679245283 1.00930366359252 0.534151023827159 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 8/5575 26/18639 0.307692307692308 1.02871334943084 0.5355745481694 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 8/5575 26/18639 0.307692307692308 1.02871334943084 0.5355745481694 1 GO:0030247 polysaccharide binding 8/5575 26/18639 0.307692307692308 1.02871334943084 0.5355745481694 1 GO:0051139 metal cation:proton antiporter activity 8/5575 26/18639 0.307692307692308 1.02871334943084 0.5355745481694 1 GO:0005245 voltage-gated calcium channel activity 13/5575 43/18639 0.302325581395349 1.01077067473146 0.539053538663209 1 GO:0008375 acetylglucosaminyltransferase activity 13/5575 43/18639 0.302325581395349 1.01077067473146 0.539053538663209 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 18/5575 60/18639 0.3 1.00299551569507 0.54266162073499 1 GO:0003688 DNA replication origin binding 5/5575 16/18639 0.3125 1.04478699551569 0.547004259632933 1 GO:0005149 interleukin-1 receptor binding 5/5575 16/18639 0.3125 1.04478699551569 0.547004259632933 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/5575 16/18639 0.3125 1.04478699551569 0.547004259632933 1 GO:0017070 U6 snRNA binding 5/5575 16/18639 0.3125 1.04478699551569 0.547004259632933 1 GO:0140328 floppase activity 5/5575 16/18639 0.3125 1.04478699551569 0.547004259632933 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 12/5575 40/18639 0.3 1.00299551569507 0.554588930368265 1 GO:0004602 glutathione peroxidase activity 7/5575 23/18639 0.304347826086957 1.0175316825892 0.556387941232173 1 GO:0005158 insulin receptor binding 7/5575 23/18639 0.304347826086957 1.0175316825892 0.556387941232173 1 GO:0016849 phosphorus-oxygen lyase activity 7/5575 23/18639 0.304347826086957 1.0175316825892 0.556387941232173 1 GO:0031681 G-protein beta-subunit binding 7/5575 23/18639 0.304347826086957 1.0175316825892 0.556387941232173 1 GO:0003678 DNA helicase activity 22/5575 74/18639 0.297297297297297 0.993959520058175 0.557407096339898 1 GO:0008194 UDP-glycosyltransferase activity 43/5575 145/18639 0.296551724137931 0.991466831606618 0.558264398347733 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 16/5575 54/18639 0.296296296296296 0.990612855007474 0.569187557120458 1 GO:0015631 tubulin binding 114/5575 385/18639 0.296103896103896 0.98996959990682 0.571081041651353 1 GO:0070851 growth factor receptor binding 41/5575 139/18639 0.294964028776978 0.986158660515534 0.574564226894531 1 GO:0002161 aminoacyl-tRNA editing activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0005172 vascular endothelial growth factor receptor binding 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0008253 5'-nucleotidase activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0019855 calcium channel inhibitor activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0045159 myosin II binding 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0046974 histone H3K9 methyltransferase activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0051011 microtubule minus-end binding 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0097157 pre-mRNA intronic binding 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0140333 glycerophospholipid flippase activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/5575 13/18639 0.307692307692308 1.02871334943084 0.57664825902466 1 GO:0010851 cyclase regulator activity 6/5575 20/18639 0.3 1.00299551569507 0.580260492840718 1 GO:0019838 growth factor binding 40/5575 136/18639 0.294117647058824 0.983328936955948 0.582950335933386 1 GO:0016597 amino acid binding 15/5575 51/18639 0.294117647058824 0.983328936955948 0.583562570056638 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/5575 27/18639 0.296296296296296 0.990612855007474 0.584824117545285 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 8/5575 27/18639 0.296296296296296 0.990612855007474 0.584824117545285 1 GO:0043178 alcohol binding 27/5575 92/18639 0.293478260869565 0.98119126535387 0.586136400453469 1 GO:0001727 lipid kinase activity 12/5575 41/18639 0.292682926829268 0.978532210434212 0.594238588274022 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 12/5575 41/18639 0.292682926829268 0.978532210434212 0.594238588274022 1 GO:0043138 3'-5' DNA helicase activity 14/5575 48/18639 0.291666666666667 0.975134529147982 0.598789279235449 1 GO:0140693 molecular condensate scaffold activity 14/5575 48/18639 0.291666666666667 0.975134529147982 0.598789279235449 1 GO:0005506 iron ion binding 45/5575 154/18639 0.292207792207792 0.976943684118572 0.604528847051401 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7/5575 24/18639 0.291666666666667 0.975134529147982 0.607819992957293 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 7/5575 24/18639 0.291666666666667 0.975134529147982 0.607819992957293 1 GO:0005315 phosphate transmembrane transporter activity 7/5575 24/18639 0.291666666666667 0.975134529147982 0.607819992957293 1 GO:0050699 WW domain binding 7/5575 24/18639 0.291666666666667 0.975134529147982 0.607819992957293 1 GO:0032183 SUMO binding 5/5575 17/18639 0.294117647058824 0.983328936955948 0.608270510932625 1 GO:0016411 acylglycerol O-acyltransferase activity 9/5575 31/18639 0.290322580645161 0.970640821640388 0.609467575668261 1 GO:0043531 ADP binding 11/5575 38/18639 0.289473684210526 0.96780269058296 0.61200909761415 1 GO:1990782 protein tyrosine kinase binding 34/5575 117/18639 0.290598290598291 0.971562607795792 0.614236644800013 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0004090 carbonyl reductase (NADPH) activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0031419 cobalamin binding 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0042975 peroxisome proliferator activated receptor binding 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0070097 delta-catenin binding 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0140940 histone H2A methyltransferase activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0141109 transporter activator activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:1990259 histone H2AQ104 methyltransferase activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:1990757 ubiquitin ligase activator activity 3/5575 10/18639 0.3 1.00299551569507 0.614872641620512 1 GO:0017022 myosin binding 22/5575 76/18639 0.289473684210526 0.96780269058296 0.615495433391118 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 17/5575 59/18639 0.288135593220339 0.963329026373793 0.621363948383243 1 GO:0036002 pre-mRNA binding 17/5575 59/18639 0.288135593220339 0.963329026373793 0.621363948383243 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 142/5575 484/18639 0.293388429752066 0.980890931327132 0.62657553468404 1 GO:0010485 histone H4 acetyltransferase activity 10/5575 35/18639 0.285714285714286 0.955233824471493 0.631217368254546 1 GO:0034061 DNA polymerase activity 10/5575 35/18639 0.285714285714286 0.955233824471493 0.631217368254546 1 GO:0036408 histone H3K14 acetyltransferase activity 8/5575 28/18639 0.285714285714286 0.955233824471493 0.631424260135355 1 GO:0050698 proteoglycan sulfotransferase activity 8/5575 28/18639 0.285714285714286 0.955233824471493 0.631424260135355 1 GO:0019894 kinesin binding 12/5575 42/18639 0.285714285714286 0.955233824471493 0.63221787802357 1 GO:1902936 phosphatidylinositol bisphosphate binding 32/5575 111/18639 0.288288288288288 0.963839534601866 0.633518582961937 1 GO:0036122 BMP binding 6/5575 21/18639 0.285714285714286 0.955233824471493 0.634015000726253 1 GO:0030170 pyridoxal phosphate binding 16/5575 56/18639 0.285714285714286 0.955233824471493 0.635956365033991 1 GO:0016782 transferase activity, transferring sulphur-containing groups 20/5575 70/18639 0.285714285714286 0.955233824471493 0.640710021959022 1 GO:0008392 arachidonate epoxygenase activity 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:0016530 metallochaperone activity 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:0034236 protein kinase A catalytic subunit binding 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:1901474 azole transmembrane transporter activity 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:1901612 cardiolipin binding 4/5575 14/18639 0.285714285714286 0.955233824471493 0.642164313586946 1 GO:0000217 DNA secondary structure binding 11/5575 39/18639 0.282051282051282 0.942987236978268 0.650679313340433 1 GO:0005544 calcium-dependent phospholipid binding 15/5575 53/18639 0.283018867924528 0.946222184617988 0.651271348969113 1 GO:0042910 xenobiotic transmembrane transporter activity 9/5575 32/18639 0.28125 0.940308295964126 0.652104052530168 1 GO:0031491 nucleosome binding 21/5575 74/18639 0.283783783783784 0.948779541873712 0.655798093381296 1 GO:0048029 monosaccharide binding 21/5575 74/18639 0.283783783783784 0.948779541873712 0.655798093381296 1 GO:0001848 complement binding 7/5575 25/18639 0.28 0.936129147982063 0.65588402582381 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 7/5575 25/18639 0.28 0.936129147982063 0.65588402582381 1 GO:0019707 protein-cysteine S-acyltransferase activity 7/5575 25/18639 0.28 0.936129147982063 0.65588402582381 1 GO:0004706 JUN kinase kinase kinase activity 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0008525 phosphatidylcholine transporter activity 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0017075 syntaxin-1 binding 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0098641 cadherin binding involved in cell-cell adhesion 5/5575 18/18639 0.277777777777778 0.928699551569507 0.664424112972317 1 GO:0001216 DNA-binding transcription activator activity 143/5575 491/18639 0.291242362525458 0.973715945311572 0.666516561504267 1 GO:0070279 vitamin B6 binding 16/5575 57/18639 0.280701754385965 0.93847533632287 0.667323348400699 1 GO:0005178 integrin binding 46/5575 161/18639 0.285714285714286 0.955233824471493 0.673599966873695 1 GO:0003785 actin monomer binding 8/5575 29/18639 0.275862068965517 0.922294727075924 0.67497214471579 1 GO:0010484 histone H3 acetyltransferase activity 8/5575 29/18639 0.275862068965517 0.922294727075924 0.67497214471579 1 GO:0033218 amide binding 71/5575 247/18639 0.287449392712551 0.961034839599862 0.679186963775964 1 GO:0015485 cholesterol binding 15/5575 54/18639 0.277777777777778 0.928699551569507 0.682842038141672 1 GO:0001784 phosphotyrosine residue binding 13/5575 47/18639 0.276595744680851 0.924747638584105 0.684338040012613 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 13/5575 47/18639 0.276595744680851 0.924747638584105 0.684338040012613 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0003953 NAD+ nucleosidase activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0004016 adenylate cyclase activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0005114 type II transforming growth factor beta receptor binding 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0005225 volume-sensitive anion channel activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0005536 D-glucose binding 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0008046 axon guidance receptor activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0008172 S-methyltransferase activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0019203 carbohydrate phosphatase activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0048185 activin binding 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0070697 activin receptor binding 3/5575 11/18639 0.272727272727273 0.911814105177334 0.685022182617264 1 GO:0032451 demethylase activity 11/5575 40/18639 0.275 0.919412556053812 0.687127389640221 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 24/5575 86/18639 0.27906976744186 0.933019084367504 0.695976675258975 1 GO:0004467 long-chain fatty acid-CoA ligase activity 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0005041 low-density lipoprotein particle receptor activity 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0008242 omega peptidase activity 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0008252 nucleotidase activity 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0010181 FMN binding 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0050700 CARD domain binding 4/5575 15/18639 0.266666666666667 0.891551569506726 0.700607032647764 1 GO:0022829 wide pore channel activity 10/5575 37/18639 0.27027027027027 0.90359956368925 0.707249704396619 1 GO:0043394 proteoglycan binding 10/5575 37/18639 0.27027027027027 0.90359956368925 0.707249704396619 1 GO:0042577 lipid phosphatase activity 5/5575 19/18639 0.263157894736842 0.879820627802691 0.715025553296836 1 GO:0050145 nucleoside monophosphate kinase activity 5/5575 19/18639 0.263157894736842 0.879820627802691 0.715025553296836 1 GO:0001968 fibronectin binding 8/5575 30/18639 0.266666666666667 0.891551569506726 0.71520431876419 1 GO:0033612 receptor serine/threonine kinase binding 8/5575 30/18639 0.266666666666667 0.891551569506726 0.71520431876419 1 GO:0043995 histone H4K5 acetyltransferase activity 8/5575 30/18639 0.266666666666667 0.891551569506726 0.71520431876419 1 GO:0043996 histone H4K8 acetyltransferase activity 8/5575 30/18639 0.266666666666667 0.891551569506726 0.71520431876419 1 GO:0043997 histone H4K12 acetyltransferase activity 8/5575 30/18639 0.266666666666667 0.891551569506726 0.71520431876419 1 GO:0009378 four-way junction helicase activity 13/5575 48/18639 0.270833333333333 0.905482062780269 0.71611329401556 1 GO:0005496 steroid binding 30/5575 108/18639 0.277777777777778 0.928699551569507 0.719503107687752 1 GO:0017124 SH3 domain binding 32/5575 115/18639 0.278260869565217 0.93031468122441 0.719947972154842 1 GO:0140828 metal cation:monoatomic cation antiporter activity 11/5575 41/18639 0.268292682926829 0.896987859564694 0.721186616807828 1 GO:0019842 vitamin binding 42/5575 150/18639 0.28 0.936129147982063 0.724019268165667 1 GO:0001786 phosphatidylserine binding 16/5575 59/18639 0.271186440677966 0.906662613057688 0.725360054471326 1 GO:0005212 structural constituent of eye lens 6/5575 23/18639 0.260869565217391 0.872170013647884 0.728314512414585 1 GO:0017134 fibroblast growth factor binding 6/5575 23/18639 0.260869565217391 0.872170013647884 0.728314512414585 1 GO:0044013 histone H2B acetyltransferase activity 6/5575 23/18639 0.260869565217391 0.872170013647884 0.728314512414585 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/5575 23/18639 0.260869565217391 0.872170013647884 0.728314512414585 1 GO:0070577 lysine-acetylated histone binding 6/5575 23/18639 0.260869565217391 0.872170013647884 0.728314512414585 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 9/5575 34/18639 0.264705882352941 0.884996043260353 0.728807096651697 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 12/5575 45/18639 0.266666666666667 0.891551569506726 0.733982031075591 1 GO:0005044 scavenger receptor activity 7/5575 27/18639 0.259259259259259 0.86678624813154 0.740593128659935 1 GO:0035255 ionotropic glutamate receptor binding 7/5575 27/18639 0.259259259259259 0.86678624813154 0.740593128659935 1 GO:0019955 cytokine binding 40/5575 144/18639 0.277777777777778 0.928699551569507 0.740626033677209 1 GO:0004000 adenosine deaminase activity 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0004032 aldose reductase (NADPH) activity 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0005025 transforming growth factor beta receptor activity, type I 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0005026 transforming growth factor beta receptor activity, type II 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0008179 adenylate cyclase binding 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0015368 calcium:monoatomic cation antiporter activity 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0016361 activin receptor activity, type I 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0016362 activin receptor activity, type II 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0017002 activin receptor activity 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0036009 protein-glutamine N-methyltransferase activity 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0042301 phosphate ion binding 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/5575 12/18639 0.25 0.835829596412556 0.745114495740814 1 GO:0035254 glutamate receptor binding 13/5575 49/18639 0.26530612244898 0.887002837009243 0.745805064901429 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0005159 insulin-like growth factor receptor binding 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0008391 arachidonate monooxygenase activity 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0015385 sodium:proton antiporter activity 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0055102 lipase inhibitor activity 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/5575 16/18639 0.25 0.835829596412556 0.75180795698604 1 GO:0008327 methyl-CpG binding 8/5575 31/18639 0.258064516129032 0.862791841458122 0.751982316362774 1 GO:0047499 calcium-independent phospholipase A2 activity 8/5575 31/18639 0.258064516129032 0.862791841458122 0.751982316362774 1 GO:0031492 nucleosomal DNA binding 11/5575 42/18639 0.261904761904762 0.875631005765535 0.752756169279661 1 GO:0042288 MHC class I protein binding 5/5575 20/18639 0.25 0.835829596412556 0.759947240115542 1 GO:0005154 epidermal growth factor receptor binding 9/5575 35/18639 0.257142857142857 0.859710442024343 0.76258815648148 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 12/5575 46/18639 0.260869565217391 0.872170013647884 0.763419789431446 1 GO:0004601 peroxidase activity 15/5575 57/18639 0.263157894736842 0.879820627802691 0.767032395976602 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 6/5575 24/18639 0.25 0.835829596412556 0.768479352233682 1 GO:0070300 phosphatidic acid binding 6/5575 24/18639 0.25 0.835829596412556 0.768479352233682 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/5575 24/18639 0.25 0.835829596412556 0.768479352233682 1 GO:0140033 acetylation-dependent protein binding 6/5575 24/18639 0.25 0.835829596412556 0.768479352233682 1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 10/5575 39/18639 0.256410256410256 0.857261124525698 0.772500376983929 1 GO:0016209 antioxidant activity 23/5575 86/18639 0.267441860465116 0.894143289185525 0.774533838749361 1 GO:0015026 coreceptor activity 16/5575 61/18639 0.262295081967213 0.876935970006616 0.776625728032897 1 GO:0046875 ephrin receptor binding 7/5575 28/18639 0.25 0.835829596412556 0.776982751501462 1 GO:0141052 histone H3 demethylase activity 7/5575 28/18639 0.25 0.835829596412556 0.776982751501462 1 GO:0120013 lipid transfer activity 17/5575 65/18639 0.261538461538462 0.874406347016212 0.785636810754829 1 GO:0061749 forked DNA-dependent helicase activity 12/5575 47/18639 0.25531914893617 0.853613204846866 0.790533532089331 1 GO:0017116 single-stranded DNA helicase activity 15/5575 58/18639 0.258620689655172 0.864651306633679 0.791407282729975 1 GO:0005035 death receptor activity 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0019104 DNA N-glycosylase activity 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0030955 potassium ion binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0031432 titin binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0039706 co-receptor binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0043560 insulin receptor substrate binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0061459 L-arginine transmembrane transporter activity 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0070123 transforming growth factor beta receptor activity, type III 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0070700 BMP receptor binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0071837 HMG box domain binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:1901338 catecholamine binding 3/5575 13/18639 0.230769230769231 0.771535012073129 0.79565436675566 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0005092 GDP-dissociation inhibitor activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0008569 minus-end-directed microtubule motor activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0015278 intracellularly gated calcium channel activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0019198 transmembrane receptor protein phosphatase activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0045125 bioactive lipid receptor activity 4/5575 17/18639 0.235294117647059 0.786663149564759 0.795973325002476 1 GO:0008373 sialyltransferase activity 5/5575 21/18639 0.238095238095238 0.796028187059577 0.799301064924695 1 GO:0015174 basic amino acid transmembrane transporter activity 5/5575 21/18639 0.238095238095238 0.796028187059577 0.799301064924695 1 GO:0140312 cargo adaptor activity 5/5575 21/18639 0.238095238095238 0.796028187059577 0.799301064924695 1 GO:0050997 quaternary ammonium group binding 10/5575 40/18639 0.25 0.835829596412556 0.800958039431832 1 GO:0072341 modified amino acid binding 24/5575 91/18639 0.263736263736264 0.881754299512147 0.802102185292669 1 GO:0003707 nuclear steroid receptor activity 6/5575 25/18639 0.24 0.802396412556054 0.804035771099957 1 GO:0005537 D-mannose binding 6/5575 25/18639 0.24 0.802396412556054 0.804035771099957 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 6/5575 25/18639 0.24 0.802396412556054 0.804035771099957 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/5575 29/18639 0.241379310344828 0.807007886191433 0.809440671842358 1 GO:0005262 calcium channel activity 35/5575 131/18639 0.267175572519084 0.893253003799678 0.814395651625124 1 GO:0036121 double-stranded DNA helicase activity 12/5575 48/18639 0.25 0.835829596412556 0.815340278113922 1 GO:0005543 phospholipid binding 140/5575 497/18639 0.28169014084507 0.941779826943725 0.818056588247749 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 10/5575 41/18639 0.24390243902439 0.815443508695177 0.826690756407317 1 GO:0042169 SH2 domain binding 10/5575 41/18639 0.24390243902439 0.815443508695177 0.826690756407317 1 GO:0005319 lipid transporter activity 48/5575 178/18639 0.269662921348315 0.901569002871971 0.827196101478232 1 GO:0031683 G-protein beta/gamma-subunit complex binding 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0032931 histone H3K56 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0043992 histone H3K9 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0043993 histone H3K18 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0043994 histone H3K23 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0043999 histone H2AK5 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044012 histone H2AK9 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044014 histone H2BK5 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044015 histone H2BK12 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044016 histone H3K4 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044017 histone H3K27 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0044018 histone H3K36 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0046972 histone H4K16 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0140908 histone H3K122 acetyltransferase activity 5/5575 22/18639 0.227272727272727 0.759845087647778 0.833370759743455 1 GO:0015172 acidic amino acid transmembrane transporter activity 4/5575 18/18639 0.222222222222222 0.742959641255605 0.83355881415395 1 GO:0030228 lipoprotein particle receptor activity 4/5575 18/18639 0.222222222222222 0.742959641255605 0.83355881415395 1 GO:0034185 apolipoprotein binding 4/5575 18/18639 0.222222222222222 0.742959641255605 0.83355881415395 1 GO:0050750 low-density lipoprotein particle receptor binding 6/5575 26/18639 0.230769230769231 0.771535012073129 0.835183931363103 1 GO:0051213 dioxygenase activity 24/5575 93/18639 0.258064516129032 0.862791841458122 0.836380884918544 1 GO:0005313 L-glutamate transmembrane transporter activity 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0008195 phosphatidate phosphatase activity 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0015386 potassium:proton antiporter activity 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0019992 diacylglycerol binding 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0032454 histone H3K9 demethylase activity 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0042043 neurexin family protein binding 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0044548 S100 protein binding 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0098821 BMP receptor activity 3/5575 14/18639 0.214285714285714 0.716425368353619 0.837515290347127 1 GO:0031210 phosphatidylcholine binding 7/5575 30/18639 0.233333333333333 0.780107623318386 0.838121301040061 1 GO:0032452 histone demethylase activity 7/5575 30/18639 0.233333333333333 0.780107623318386 0.838121301040061 1 GO:0015085 calcium ion transmembrane transporter activity 39/5575 147/18639 0.26530612244898 0.887002837009243 0.838632665278896 1 GO:0008376 acetylgalactosaminyltransferase activity 8/5575 34/18639 0.235294117647059 0.786663149564759 0.841703920458616 1 GO:0000182 rDNA binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0001094 TFIID-class transcription factor complex binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0004935 adrenergic receptor activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0005031 tumor necrosis factor receptor activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0015187 glycine transmembrane transporter activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0015203 polyamine transmembrane transporter activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0015643 toxic substance binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0019911 structural constituent of myelin sheath 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0031434 mitogen-activated protein kinase kinase binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0043208 glycosphingolipid binding 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0050308 sugar-phosphatase activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0140135 mechanosensitive monoatomic cation channel activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0140999 histone H3K4 trimethyltransferase activity 2/5575 10/18639 0.2 0.668663677130045 0.849363185174878 1 GO:0008081 phosphoric diester hydrolase activity 22/5575 87/18639 0.252873563218391 0.84543683315293 0.856306485090188 1 GO:0038024 cargo receptor activity 16/5575 65/18639 0.246153846153846 0.822970679544671 0.858382554652152 1 GO:0004857 enzyme inhibitor activity 115/5575 416/18639 0.276442307692308 0.924234649879269 0.859104271006228 1 GO:0005104 fibroblast growth factor receptor binding 6/5575 27/18639 0.222222222222222 0.742959641255605 0.86220987499258 1 GO:0016405 CoA-ligase activity 6/5575 27/18639 0.222222222222222 0.742959641255605 0.86220987499258 1 GO:0005452 solute:inorganic anion antiporter activity 7/5575 31/18639 0.225806451612903 0.754942861275857 0.863245171570936 1 GO:0070325 lipoprotein particle receptor binding 7/5575 31/18639 0.225806451612903 0.754942861275857 0.863245171570936 1 GO:0140457 protein demethylase activity 7/5575 31/18639 0.225806451612903 0.754942861275857 0.863245171570936 1 GO:0004623 phospholipase A2 activity 8/5575 35/18639 0.228571428571429 0.764187059577194 0.865145628303693 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0008301 DNA binding, bending 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0015245 fatty acid transmembrane transporter activity 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0022821 solute:potassium antiporter activity 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0043395 heparan sulfate proteoglycan binding 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0046624 sphingolipid transporter activity 4/5575 19/18639 0.210526315789474 0.703856502242152 0.865167683715847 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/5575 15/18639 0.2 0.668663677130045 0.871742354771968 1 GO:0033130 acetylcholine receptor binding 3/5575 15/18639 0.2 0.668663677130045 0.871742354771968 1 GO:0034483 heparan sulfate sulfotransferase activity 3/5575 15/18639 0.2 0.668663677130045 0.871742354771968 1 GO:0120283 protein serine/threonine kinase binding 3/5575 15/18639 0.2 0.668663677130045 0.871742354771968 1 GO:0046982 protein heterodimerization activity 101/5575 369/18639 0.273712737127371 0.915108826424587 0.871960244736653 1 GO:0001618 virus receptor activity 20/5575 81/18639 0.246913580246914 0.825510712506228 0.87616002265956 1 GO:0004713 protein tyrosine kinase activity 36/5575 140/18639 0.257142857142857 0.859710442024343 0.882319520249264 1 GO:0047498 calcium-dependent phospholipase A2 activity 7/5575 32/18639 0.21875 0.731350896860987 0.885076799738178 1 GO:0120015 sterol transfer activity 7/5575 32/18639 0.21875 0.731350896860987 0.885076799738178 1 GO:0051959 dynein light intermediate chain binding 6/5575 28/18639 0.214285714285714 0.716425368353619 0.885453635944703 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0001851 complement component C3b binding 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0002162 dystroglycan binding 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0008432 JUN kinase binding 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0008503 benzodiazepine receptor activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0015205 nucleobase transmembrane transporter activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0016594 glycine binding 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/5575 11/18639 0.181818181818182 0.607876070118223 0.885883407965459 1 GO:0035401 histone H3Y41 kinase activity 29/5575 115/18639 0.252173913043478 0.843097679859622 0.887211005963139 1 GO:0140801 histone H2AXY142 kinase activity 29/5575 115/18639 0.252173913043478 0.843097679859622 0.887211005963139 1 GO:0043998 histone H2A acetyltransferase activity 5/5575 24/18639 0.208333333333333 0.69652466367713 0.887309287098263 1 GO:0070840 dynein complex binding 5/5575 24/18639 0.208333333333333 0.69652466367713 0.887309287098263 1 GO:0140272 exogenous protein binding 20/5575 82/18639 0.24390243902439 0.815443508695177 0.889553717854552 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 47/5575 181/18639 0.259668508287293 0.868154497931274 0.894835026619226 1 GO:0005024 transforming growth factor beta receptor activity 3/5575 16/18639 0.1875 0.626872197309417 0.899419523491797 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/5575 16/18639 0.1875 0.626872197309417 0.899419523491797 1 GO:0019841 retinol binding 3/5575 16/18639 0.1875 0.626872197309417 0.899419523491797 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/5575 16/18639 0.1875 0.626872197309417 0.899419523491797 1 GO:0030551 cyclic nucleotide binding 8/5575 37/18639 0.216216216216216 0.7228796509514 0.903541750720035 1 GO:0001530 lipopolysaccharide binding 9/5575 41/18639 0.219512195121951 0.733899157825659 0.903891363407415 1 GO:0015297 antiporter activity 34/5575 135/18639 0.251851851851852 0.842020926756353 0.904490128611633 1 GO:0008146 sulfotransferase activity 12/5575 53/18639 0.226415094339623 0.75697774769439 0.907469052059358 1 GO:0015645 fatty acid ligase activity 5/5575 25/18639 0.2 0.668663677130045 0.908127666097839 1 GO:0120515 fatty acid-CoA ligase activity 5/5575 25/18639 0.2 0.668663677130045 0.908127666097839 1 GO:0008017 microtubule binding 73/5575 276/18639 0.264492753623188 0.884283486059661 0.909681088719764 1 GO:0015125 bile acid transmembrane transporter activity 4/5575 21/18639 0.19047619047619 0.636822549647662 0.913160260425623 1 GO:0019200 carbohydrate kinase activity 4/5575 21/18639 0.19047619047619 0.636822549647662 0.913160260425623 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/5575 21/18639 0.19047619047619 0.636822549647662 0.913160260425623 1 GO:0061891 calcium ion sensor activity 4/5575 21/18639 0.19047619047619 0.636822549647662 0.913160260425623 1 GO:0003720 telomerase activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0005165 neurotrophin receptor binding 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0008603 cAMP-dependent protein kinase regulator activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0010853 cyclase activator activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0015166 polyol transmembrane transporter activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0017166 vinculin binding 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0045295 gamma-catenin binding 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0070008 serine-type exopeptidase activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0070410 co-SMAD binding 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0140900 chloride:bicarbonate antiporter activity 2/5575 12/18639 0.166666666666667 0.557219730941704 0.914037190410388 1 GO:0022804 active transmembrane transporter activity 124/5575 457/18639 0.271334792122538 0.907158599169864 0.914744953358935 1 GO:0051015 actin filament binding 54/5575 209/18639 0.258373205741627 0.863823889115369 0.916055876679413 1 GO:0004175 endopeptidase activity 109/5575 405/18639 0.269135802469136 0.899806676631789 0.918285765764904 1 GO:0004180 carboxypeptidase activity 10/5575 46/18639 0.217391304347826 0.726808344706571 0.918841566502998 1 GO:0008429 phosphatidylethanolamine binding 3/5575 17/18639 0.176470588235294 0.589997362173569 0.921586566025223 1 GO:0036041 long-chain fatty acid binding 3/5575 17/18639 0.176470588235294 0.589997362173569 0.921586566025223 1 GO:0038191 neuropilin binding 3/5575 17/18639 0.176470588235294 0.589997362173569 0.921586566025223 1 GO:0045236 CXCR chemokine receptor binding 3/5575 17/18639 0.176470588235294 0.589997362173569 0.921586566025223 1 GO:0070492 oligosaccharide binding 3/5575 17/18639 0.176470588235294 0.589997362173569 0.921586566025223 1 GO:0098918 structural constituent of synapse 6/5575 30/18639 0.2 0.668663677130045 0.922073555791193 1 GO:0015179 L-amino acid transmembrane transporter activity 14/5575 62/18639 0.225806451612903 0.754942861275857 0.922705820071808 1 GO:0043548 phosphatidylinositol 3-kinase binding 5/5575 26/18639 0.192307692307692 0.642945843394274 0.925495221987062 1 GO:0008970 phospholipase A1 activity 4/5575 22/18639 0.181818181818182 0.607876070118223 0.930891260577216 1 GO:0016881 acid-amino acid ligase activity 4/5575 22/18639 0.181818181818182 0.607876070118223 0.930891260577216 1 GO:0033038 bitter taste receptor activity 4/5575 22/18639 0.181818181818182 0.607876070118223 0.930891260577216 1 GO:0140784 metal ion sensor activity 4/5575 22/18639 0.181818181818182 0.607876070118223 0.930891260577216 1 GO:1901682 sulfur compound transmembrane transporter activity 14/5575 63/18639 0.222222222222222 0.742959641255605 0.933113797095156 1 GO:0004620 phospholipase activity 26/5575 109/18639 0.238532110091743 0.797488789237668 0.934486115939706 1 GO:0003964 RNA-directed DNA polymerase activity 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0005542 folic acid binding 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0008035 high-density lipoprotein particle binding 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0071714 icosanoid transmembrane transporter activity 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0089720 caspase binding 2/5575 13/18639 0.153846153846154 0.514356674715419 0.935561340165793 1 GO:0033293 monocarboxylic acid binding 18/5575 79/18639 0.227848101265823 0.761768746097519 0.93756485793547 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/5575 18/18639 0.166666666666667 0.557219730941704 0.939192116399478 1 GO:0035615 clathrin adaptor activity 3/5575 18/18639 0.166666666666667 0.557219730941704 0.939192116399478 1 GO:0050811 GABA receptor binding 3/5575 18/18639 0.166666666666667 0.557219730941704 0.939192116399478 1 GO:0008395 steroid hydroxylase activity 5/5575 27/18639 0.185185185185185 0.619133034379671 0.939878255394898 1 GO:0015252 proton channel activity 5/5575 27/18639 0.185185185185185 0.619133034379671 0.939878255394898 1 GO:0023026 MHC class II protein complex binding 5/5575 27/18639 0.185185185185185 0.619133034379671 0.939878255394898 1 GO:0004497 monooxygenase activity 25/5575 106/18639 0.235849056603774 0.788518487181657 0.940058302072127 1 GO:0019212 phosphatase inhibitor activity 12/5575 56/18639 0.214285714285714 0.716425368353619 0.941535093953673 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/5575 60/18639 0.216666666666667 0.724385650224215 0.941822406659389 1 GO:0043274 phospholipase binding 4/5575 23/18639 0.173913043478261 0.581446675765256 0.945278252137022 1 GO:0099186 structural constituent of postsynapse 4/5575 23/18639 0.173913043478261 0.581446675765256 0.945278252137022 1 GO:0048306 calcium-dependent protein binding 18/5575 80/18639 0.225 0.752246636771301 0.945450455688716 1 GO:0015106 bicarbonate transmembrane transporter activity 6/5575 32/18639 0.1875 0.626872197309417 0.947988268373104 1 GO:0004864 protein phosphatase inhibitor activity 11/5575 53/18639 0.207547169811321 0.693896268719858 0.950401197311748 1 GO:0045499 chemorepellent activity 5/5575 28/18639 0.178571428571429 0.597021140294683 0.95170969440581 1 GO:0008494 translation activator activity 2/5575 14/18639 0.142857142857143 0.477616912235746 0.951902348468904 1 GO:0015926 glucosidase activity 2/5575 14/18639 0.142857142857143 0.477616912235746 0.951902348468904 1 GO:0032036 myosin heavy chain binding 2/5575 14/18639 0.142857142857143 0.477616912235746 0.951902348468904 1 GO:0043176 amine binding 2/5575 14/18639 0.142857142857143 0.477616912235746 0.951902348468904 1 GO:0005229 intracellularly calcium-gated chloride channel activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0016918 retinal binding 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0022840 leak channel activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0022842 narrow pore channel activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0030506 ankyrin binding 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0031420 alkali metal ion binding 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0141147 intracellularly calcium-gated channel activity 3/5575 19/18639 0.157894736842105 0.527892376681614 0.953071697527659 1 GO:0042277 peptide binding 63/5575 249/18639 0.253012048192771 0.845899832513912 0.954203832825609 1 GO:0023023 MHC protein complex binding 7/5575 37/18639 0.189189189189189 0.632519694582475 0.95511550461912 1 GO:0015149 hexose transmembrane transporter activity 4/5575 24/18639 0.166666666666667 0.557219730941704 0.956872045144774 1 GO:0055056 D-glucose transmembrane transporter activity 4/5575 24/18639 0.166666666666667 0.557219730941704 0.956872045144774 1 GO:0019956 chemokine binding 6/5575 33/18639 0.181818181818182 0.607876070118223 0.957784339482091 1 GO:0031490 chromatin DNA binding 30/5575 128/18639 0.234375 0.783590246636771 0.958218821391755 1 GO:0051861 glycolipid binding 5/5575 29/18639 0.172413793103448 0.576434204422453 0.961381900565153 1 GO:0099604 ligand-gated calcium channel activity 5/5575 29/18639 0.172413793103448 0.576434204422453 0.961381900565153 1 GO:0030627 pre-mRNA 5'-splice site binding 3/5575 20/18639 0.15 0.501497757847534 0.963942092159142 1 GO:0046906 tetrapyrrole binding 36/5575 152/18639 0.236842105263158 0.791838565022422 0.964196110666735 1 GO:0005523 tropomyosin binding 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0015116 sulfate transmembrane transporter activity 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0017081 chloride channel regulator activity 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0030553 cGMP binding 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0045504 dynein heavy chain binding 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0047372 monoacylglycerol lipase activity 2/5575 15/18639 0.133333333333333 0.445775784753363 0.964234655191509 1 GO:0098632 cell-cell adhesion mediator activity 11/5575 55/18639 0.2 0.668663677130045 0.964712414458574 1 GO:0005021 vascular endothelial growth factor receptor activity 10/5575 51/18639 0.196078431372549 0.655552624637299 0.965528262331299 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/5575 25/18639 0.16 0.534930941704036 0.966156688772761 1 GO:0015662 P-type ion transporter activity 4/5575 25/18639 0.16 0.534930941704036 0.966156688772761 1 GO:0120020 cholesterol transfer activity 4/5575 25/18639 0.16 0.534930941704036 0.966156688772761 1 GO:0140358 P-type transmembrane transporter activity 4/5575 25/18639 0.16 0.534930941704036 0.966156688772761 1 GO:0005504 fatty acid binding 9/5575 47/18639 0.191489361702128 0.640209903635149 0.966649210043498 1 GO:0016298 lipase activity 30/5575 130/18639 0.230769230769231 0.771535012073129 0.966943453198544 1 GO:0005126 cytokine receptor binding 69/5575 275/18639 0.250909090909091 0.838868976763147 0.967660141781729 1 GO:0031406 carboxylic acid binding 45/5575 187/18639 0.240641711229947 0.804541857509412 0.968832375651311 1 GO:0020037 heme binding 33/5575 142/18639 0.232394366197183 0.776968357228573 0.96916611657591 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0004955 prostaglandin receptor activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0005131 growth hormone receptor binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0008190 eukaryotic initiation factor 4E binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0008519 ammonium channel activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0019531 oxalate transmembrane transporter activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0032395 MHC class II receptor activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0035374 chondroitin sulfate binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0051378 serotonin binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0070739 protein-glutamic acid ligase activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0070740 tubulin-glutamic acid ligase activity 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0071723 lipopeptide binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:1990763 arrestin family protein binding 1/5575 10/18639 0.1 0.334331838565022 0.971418303647381 1 GO:0005516 calmodulin binding 50/5575 207/18639 0.241545893719807 0.807564827451745 0.972876357718602 1 GO:0015101 organic cation transmembrane transporter activity 17/5575 81/18639 0.209876543209877 0.701684105630294 0.973234042771508 1 GO:0015378 sodium:chloride symporter activity 2/5575 16/18639 0.125 0.417914798206278 0.973493959720039 1 GO:0022841 potassium ion leak channel activity 2/5575 16/18639 0.125 0.417914798206278 0.973493959720039 1 GO:0015145 monosaccharide transmembrane transporter activity 4/5575 26/18639 0.153846153846154 0.514356674715419 0.973549682733797 1 GO:0030507 spectrin binding 4/5575 26/18639 0.153846153846154 0.514356674715419 0.973549682733797 1 GO:0043177 organic acid binding 45/5575 189/18639 0.238095238095238 0.796028187059577 0.974630619698116 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/5575 31/18639 0.161290322580645 0.539244900911326 0.975599569811462 1 GO:0042562 hormone binding 20/5575 94/18639 0.212765957446809 0.711344337372388 0.977116489286827 1 GO:0019199 transmembrane receptor protein kinase activity 16/5575 78/18639 0.205128205128205 0.685808899620559 0.977150939466054 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 14/5575 70/18639 0.2 0.668663677130045 0.977649681466873 1 GO:0004190 aspartic-type endopeptidase activity 6/5575 36/18639 0.166666666666667 0.557219730941704 0.977951795079559 1 GO:0016247 channel regulator activity 39/5575 168/18639 0.232142857142857 0.776127482383088 0.97869258911819 1 GO:0005243 gap junction channel activity 3/5575 22/18639 0.136363636363636 0.455907052588667 0.978960647129423 1 GO:0015377 chloride:monoatomic cation symporter activity 3/5575 22/18639 0.136363636363636 0.455907052588667 0.978960647129423 1 GO:0008514 organic anion transmembrane transporter activity 66/5575 269/18639 0.245353159851301 0.820293730308233 0.979149653936454 1 GO:0003774 cytoskeletal motor activity 35/5575 153/18639 0.228758169934641 0.764811395410182 0.979238690336586 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0004954 prostanoid receptor activity 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0008199 ferric iron binding 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0032794 GTPase activating protein binding 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0042608 T cell receptor binding 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0050786 RAGE receptor binding 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/5575 11/18639 0.0909090909090909 0.303938035059111 0.979971793215573 1 GO:0042287 MHC protein binding 7/5575 41/18639 0.170731707317073 0.570810456086624 0.980320309325545 1 GO:0005253 monoatomic anion channel activity 22/5575 103/18639 0.213592233009709 0.714106839653446 0.980404592288207 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/5575 17/18639 0.117647058823529 0.393331574782379 0.980414945546015 1 GO:0009881 photoreceptor activity 2/5575 17/18639 0.117647058823529 0.393331574782379 0.980414945546015 1 GO:0030169 low-density lipoprotein particle binding 2/5575 17/18639 0.117647058823529 0.393331574782379 0.980414945546015 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/5575 17/18639 0.117647058823529 0.393331574782379 0.980414945546015 1 GO:0005007 fibroblast growth factor receptor activity 9/5575 50/18639 0.18 0.60179730941704 0.981268408763921 1 GO:0005017 platelet-derived growth factor receptor activity 9/5575 50/18639 0.18 0.60179730941704 0.981268408763921 1 GO:0005019 platelet-derived growth factor beta-receptor activity 9/5575 50/18639 0.18 0.60179730941704 0.981268408763921 1 GO:0070001 aspartic-type peptidase activity 6/5575 37/18639 0.162162162162162 0.54215973821355 0.98237172226545 1 GO:0141108 transporter regulator activity 39/5575 170/18639 0.229411764705882 0.76699657082564 0.983048075087306 1 GO:0098631 cell adhesion mediator activity 15/5575 76/18639 0.197368421052632 0.659865470852018 0.983702623069385 1 GO:0005283 amino acid:sodium symporter activity 3/5575 23/18639 0.130434782608696 0.436085006823942 0.984013006378283 1 GO:0016917 GABA receptor activity 3/5575 23/18639 0.130434782608696 0.436085006823942 0.984013006378283 1 GO:0008527 taste receptor activity 4/5575 28/18639 0.142857142857143 0.477616912235746 0.984021564596354 1 GO:0051119 sugar transmembrane transporter activity 4/5575 28/18639 0.142857142857143 0.477616912235746 0.984021564596354 1 GO:0042056 chemoattractant activity 7/5575 42/18639 0.166666666666667 0.557219730941704 0.984123401844375 1 GO:0004970 glutamate-gated receptor activity 2/5575 18/18639 0.111111111111111 0.371479820627803 0.985567799189332 1 GO:0015373 monoatomic anion:sodium symporter activity 2/5575 18/18639 0.111111111111111 0.371479820627803 0.985567799189332 1 GO:0022851 GABA-gated chloride ion channel activity 2/5575 18/18639 0.111111111111111 0.371479820627803 0.985567799189332 1 GO:0005436 sodium:phosphate symporter activity 1/5575 12/18639 0.0833333333333333 0.278609865470852 0.985965848016044 1 GO:0008504 monoamine transmembrane transporter activity 1/5575 12/18639 0.0833333333333333 0.278609865470852 0.985965848016044 1 GO:0015132 prostaglandin transmembrane transporter activity 1/5575 12/18639 0.0833333333333333 0.278609865470852 0.985965848016044 1 GO:0016208 AMP binding 1/5575 12/18639 0.0833333333333333 0.278609865470852 0.985965848016044 1 GO:0097371 MDM2/MDM4 family protein binding 1/5575 12/18639 0.0833333333333333 0.278609865470852 0.985965848016044 1 GO:0170055 lipid transmembrane transporter activity 10/5575 56/18639 0.178571428571429 0.597021140294683 0.986513616328351 1 GO:0008201 heparin binding 39/5575 172/18639 0.226744186046512 0.758078006048597 0.98659083575393 1 GO:0003779 actin binding 112/5575 443/18639 0.252821670428894 0.845263339035723 0.987278014057714 1 GO:0030159 signaling receptor complex adaptor activity 9/5575 52/18639 0.173076923076923 0.578651259054846 0.987443817378839 1 GO:0004181 metallocarboxypeptidase activity 4/5575 29/18639 0.137931034482759 0.461147363537962 0.987643910841347 1 GO:0004629 phospholipase C activity 4/5575 29/18639 0.137931034482759 0.461147363537962 0.987643910841347 1 GO:0005416 amino acid:monoatomic cation symporter activity 4/5575 29/18639 0.137931034482759 0.461147363537962 0.987643910841347 1 GO:0019957 C-C chemokine binding 3/5575 24/18639 0.125 0.417914798206278 0.987890286554499 1 GO:0030552 cAMP binding 3/5575 24/18639 0.125 0.417914798206278 0.987890286554499 1 GO:0004890 GABA-A receptor activity 2/5575 19/18639 0.105263157894737 0.351928251121076 0.989390869973058 1 GO:0005003 ephrin receptor activity 9/5575 53/18639 0.169811320754717 0.567733310770793 0.989764065567021 1 GO:0005005 transmembrane-ephrin receptor activity 9/5575 53/18639 0.169811320754717 0.567733310770793 0.989764065567021 1 GO:0017046 peptide hormone binding 9/5575 53/18639 0.169811320754717 0.567733310770793 0.989764065567021 1 GO:0001540 amyloid-beta binding 16/5575 83/18639 0.192771084337349 0.64449511048679 0.989942420012668 1 GO:0004993 G protein-coupled serotonin receptor activity 1/5575 13/18639 0.0769230769230769 0.25717833735771 0.990166223670232 1 GO:0035325 Toll-like receptor binding 1/5575 13/18639 0.0769230769230769 0.25717833735771 0.990166223670232 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/5575 30/18639 0.133333333333333 0.445775784753363 0.990474732583101 1 GO:0022839 monoatomic ion-gated channel activity 4/5575 30/18639 0.133333333333333 0.445775784753363 0.990474732583101 1 GO:0005004 GPI-linked ephrin receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0005008 hepatocyte growth factor receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0005009 insulin receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0005011 macrophage colony-stimulating factor receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0005020 stem cell factor receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0008288 boss receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0036332 placental growth factor receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0038062 protein tyrosine kinase collagen receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0060175 brain-derived neurotrophic factor receptor activity 8/5575 49/18639 0.163265306122449 0.545847899697996 0.99072895210261 1 GO:0015271 outward rectifier potassium channel activity 3/5575 25/18639 0.12 0.401198206278027 0.990853958979281 1 GO:0015144 carbohydrate transmembrane transporter activity 6/5575 40/18639 0.15 0.501497757847534 0.991162326823462 1 GO:0099106 ion channel regulator activity 35/5575 160/18639 0.21875 0.731350896860987 0.991260514268234 1 GO:0050840 extracellular matrix binding 12/5575 67/18639 0.17910447761194 0.598803292952279 0.991443460284683 1 GO:0042605 peptide antigen binding 7/5575 45/18639 0.155555555555556 0.520071748878924 0.991815844165672 1 GO:0061134 peptidase regulator activity 52/5575 226/18639 0.230088495575221 0.769259097583237 0.991888585980428 1 GO:0001614 purinergic nucleotide receptor activity 2/5575 20/18639 0.1 0.334331838565022 0.992218511952382 1 GO:0001972 retinoic acid binding 2/5575 20/18639 0.1 0.334331838565022 0.992218511952382 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/5575 20/18639 0.1 0.334331838565022 0.992218511952382 1 GO:0016502 nucleotide receptor activity 2/5575 20/18639 0.1 0.334331838565022 0.992218511952382 1 GO:0005006 epidermal growth factor receptor activity 8/5575 50/18639 0.16 0.534930941704036 0.992530960357598 1 GO:0003777 microtubule motor activity 12/5575 68/18639 0.176470588235294 0.589997362173569 0.992929809210538 1 GO:0017080 sodium channel regulator activity 6/5575 41/18639 0.146341463414634 0.489266105217106 0.993020958394534 1 GO:0031404 chloride ion binding 1/5575 14/18639 0.0714285714285714 0.238808456117873 0.993109598685719 1 GO:0004435 phosphatidylinositol phospholipase C activity 3/5575 26/18639 0.115384615384615 0.385767506036564 0.993111038489562 1 GO:0005227 calcium-activated cation channel activity 3/5575 26/18639 0.115384615384615 0.385767506036564 0.993111038489562 1 GO:0008066 glutamate receptor activity 3/5575 26/18639 0.115384615384615 0.385767506036564 0.993111038489562 1 GO:0015171 amino acid transmembrane transporter activity 20/5575 102/18639 0.196078431372549 0.655552624637299 0.993319390094822 1 GO:0005010 insulin-like growth factor receptor activity 8/5575 51/18639 0.156862745098039 0.524442099709839 0.993998804650138 1 GO:0005030 neurotrophin receptor activity 8/5575 51/18639 0.156862745098039 0.524442099709839 0.993998804650138 1 GO:0005248 voltage-gated sodium channel activity 2/5575 21/18639 0.0952380952380952 0.318411274823831 0.994304067865118 1 GO:0071813 lipoprotein particle binding 4/5575 32/18639 0.125 0.417914798206278 0.994387844203921 1 GO:0071814 protein-lipid complex binding 4/5575 32/18639 0.125 0.417914798206278 0.994387844203921 1 GO:0005200 structural constituent of cytoskeleton 22/5575 112/18639 0.196428571428571 0.656723254324151 0.994983438050288 1 GO:0030246 carbohydrate binding 65/5575 280/18639 0.232142857142857 0.776127482383088 0.995136872261015 1 GO:0005539 glycosaminoglycan binding 55/5575 242/18639 0.227272727272727 0.759845087647778 0.99514259855221 1 GO:0004089 carbonate dehydratase activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0004953 icosanoid receptor activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0008020 G protein-coupled photoreceptor activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0015250 water channel activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0140161 monocarboxylate:sodium symporter activity 1/5575 15/18639 0.0666666666666667 0.222887892376682 0.995172094649591 1 GO:0004896 cytokine receptor activity 18/5575 96/18639 0.1875 0.626872197309417 0.995459774125772 1 GO:0030296 protein tyrosine kinase activator activity 4/5575 33/18639 0.121212121212121 0.405250713412148 0.995709321052836 1 GO:0008083 growth factor activity 34/5575 162/18639 0.209876543209877 0.701684105630294 0.996051159578017 1 GO:0005242 inward rectifier potassium channel activity 3/5575 28/18639 0.107142857142857 0.35821268417681 0.996120539105606 1 GO:0038064 collagen receptor activity 8/5575 53/18639 0.150943396226415 0.50465183179626 0.996155341397758 1 GO:0016500 protein-hormone receptor activity 11/5575 67/18639 0.164179104477612 0.548903018539589 0.996404724168755 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/5575 16/18639 0.0625 0.208957399103139 0.996617303644894 1 GO:0016493 C-C chemokine receptor activity 2/5575 23/18639 0.0869565217391304 0.290723337882628 0.996964638849202 1 GO:0043236 laminin binding 3/5575 29/18639 0.103448275862069 0.345860522653472 0.997098611597636 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/5575 17/18639 0.0588235294117647 0.19666578739119 0.997629951026074 1 GO:0030548 acetylcholine receptor regulator activity 1/5575 17/18639 0.0588235294117647 0.19666578739119 0.997629951026074 1 GO:0004806 triacylglycerol lipase activity 2/5575 24/18639 0.0833333333333333 0.278609865470852 0.997789579966902 1 GO:0030215 semaphorin receptor binding 2/5575 24/18639 0.0833333333333333 0.278609865470852 0.997789579966902 1 GO:0048019 receptor antagonist activity 3/5575 30/18639 0.1 0.334331838565022 0.997834598154807 1 GO:0005254 chloride channel activity 14/5575 83/18639 0.168674698795181 0.563933221675941 0.997898488523105 1 GO:0005372 water transmembrane transporter activity 1/5575 18/18639 0.0555555555555556 0.185739910313901 0.998339489369412 1 GO:0015280 ligand-gated sodium channel activity 1/5575 18/18639 0.0555555555555556 0.185739910313901 0.998339489369412 1 GO:0099602 neurotransmitter receptor regulator activity 1/5575 18/18639 0.0555555555555556 0.185739910313901 0.998339489369412 1 GO:0005251 delayed rectifier potassium channel activity 2/5575 25/18639 0.08 0.267465470852018 0.998392677444087 1 GO:0099095 ligand-gated monoatomic anion channel activity 6/5575 47/18639 0.127659574468085 0.426806602423433 0.998396440068622 1 GO:0015291 secondary active transmembrane transporter activity 64/5575 287/18639 0.222996515679443 0.745548350807019 0.998546520291522 1 GO:0008509 monoatomic anion transmembrane transporter activity 29/5575 149/18639 0.194630872483221 0.650712974388299 0.998638684946902 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/5575 26/18639 0.0769230769230769 0.25717833735771 0.99883281402363 1 GO:0004950 chemokine receptor activity 2/5575 26/18639 0.0769230769230769 0.25717833735771 0.99883281402363 1 GO:0008574 plus-end-directed microtubule motor activity 1/5575 19/18639 0.0526315789473684 0.175964125560538 0.998836634891432 1 GO:0042834 peptidoglycan binding 1/5575 19/18639 0.0526315789473684 0.175964125560538 0.998836634891432 1 GO:0099589 serotonin receptor activity 1/5575 19/18639 0.0526315789473684 0.175964125560538 0.998836634891432 1 GO:0005501 retinoid binding 4/5575 38/18639 0.105263157894737 0.351928251121076 0.998917230050146 1 GO:0019840 isoprenoid binding 4/5575 38/18639 0.105263157894737 0.351928251121076 0.998917230050146 1 GO:0046943 carboxylic acid transmembrane transporter activity 38/5575 188/18639 0.202127659574468 0.675777120503769 0.999046056756718 1 GO:0005342 organic acid transmembrane transporter activity 38/5575 189/18639 0.201058201058201 0.672201580183643 0.999175933694867 1 GO:0015464 acetylcholine receptor activity 1/5575 20/18639 0.05 0.167165919282511 0.999184957151382 1 GO:0015103 inorganic anion transmembrane transporter activity 32/5575 165/18639 0.193939393939394 0.648401141459438 0.999233401558707 1 GO:0008009 chemokine activity 5/5575 45/18639 0.111111111111111 0.371479820627803 0.999300210756058 1 GO:0001664 G protein-coupled receptor binding 65/5575 297/18639 0.218855218855219 0.731702676994157 0.999300621318625 1 GO:0019825 oxygen binding 3/5575 34/18639 0.0882352941176471 0.294998681086785 0.999340429366983 1 GO:0051428 peptide hormone receptor binding 1/5575 21/18639 0.0476190476190476 0.159205637411915 0.999429001615695 1 GO:0005343 organic acid:sodium symporter activity 3/5575 35/18639 0.0857142857142857 0.286570147341448 0.999512014672582 1 GO:0005244 voltage-gated monoatomic ion channel activity 33/5575 173/18639 0.190751445086705 0.637742813447731 0.999584540085597 1 GO:0033691 sialic acid binding 1/5575 22/18639 0.0454545454545455 0.151969017529556 0.999599982171743 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/5575 36/18639 0.0833333333333333 0.278609865470852 0.999639493757546 1 GO:0001965 G-protein alpha-subunit binding 2/5575 30/18639 0.0666666666666667 0.222887892376682 0.999679281079975 1 GO:0022832 voltage-gated channel activity 33/5575 175/18639 0.188571428571429 0.630454324151185 0.999698923805875 1 GO:0015459 potassium channel regulator activity 7/5575 59/18639 0.11864406779661 0.396664893212738 0.99972238491004 1 GO:0061135 endopeptidase regulator activity 35/5575 184/18639 0.190217391304348 0.635957301618249 0.999730447605647 1 GO:0015294 solute:monoatomic cation symporter activity 19/5575 116/18639 0.163793103448276 0.54761249420133 0.999748363326385 1 GO:0030414 peptidase inhibitor activity 31/5575 169/18639 0.183431952662722 0.613271419853 0.999796918394742 1 GO:0000146 microfilament motor activity 3/5575 38/18639 0.0789473684210526 0.263946188340807 0.999804055355698 1 GO:0030547 signaling receptor inhibitor activity 4/5575 44/18639 0.0909090909090909 0.303938035059111 0.999805056158773 1 GO:0015293 symporter activity 25/5575 146/18639 0.171232876712329 0.572486024940107 0.999873395419309 1 GO:0004866 endopeptidase inhibitor activity 28/5575 161/18639 0.173913043478261 0.581446675765256 0.999911952112466 1 GO:0015020 glucuronosyltransferase activity 2/5575 34/18639 0.0588235294117647 0.19666578739119 0.99991325273154 1 GO:0051427 hormone receptor binding 2/5575 34/18639 0.0588235294117647 0.19666578739119 0.99991325273154 1 GO:0008227 G protein-coupled amine receptor activity 3/5575 41/18639 0.0731707317073171 0.244633052608553 0.99992221377288 1 GO:0004252 serine-type endopeptidase activity 31/5575 176/18639 0.176136363636364 0.588879942927028 0.999939275542159 1 GO:0008307 structural constituent of muscle 3/5575 42/18639 0.0714285714285714 0.238808456117873 0.999942960739333 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/5575 36/18639 0.0555555555555556 0.185739910313901 0.99995510409743 1 GO:0022843 voltage-gated monoatomic cation channel activity 23/5575 143/18639 0.160839160839161 0.53773652356612 0.999958088935488 1 GO:0042379 chemokine receptor binding 8/5575 72/18639 0.111111111111111 0.371479820627803 0.999962648066932 1 GO:0015108 chloride transmembrane transporter activity 18/5575 121/18639 0.148760330578512 0.497353148278546 0.999963859769481 1 GO:0048020 CCR chemokine receptor binding 4/5575 50/18639 0.08 0.267465470852018 0.999966698927914 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 5/5575 56/18639 0.0892857142857143 0.298510570147341 0.999967402562132 1 GO:0030280 structural constituent of skin epidermis 2/5575 37/18639 0.0540540540540541 0.18071991273785 0.999967736169765 1 GO:0017171 serine hydrolase activity 35/5575 198/18639 0.176767676767677 0.59099062372605 0.999974094633777 1 GO:0005272 sodium channel activity 4/5575 51/18639 0.0784313725490196 0.26222104985492 0.999975299964874 1 GO:0008236 serine-type peptidase activity 34/5575 194/18639 0.175257731958763 0.585942397485091 0.99997537523151 1 GO:0004867 serine-type endopeptidase inhibitor activity 12/5575 95/18639 0.126315789473684 0.422313901345292 0.999980318700937 1 GO:0005184 neuropeptide hormone activity 1/5575 31/18639 0.032258064516129 0.107848980182265 0.999983758329227 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/5575 53/18639 0.0754716981132075 0.25232591589813 0.999986455549553 1 GO:0071855 neuropeptide receptor binding 2/5575 40/18639 0.05 0.167165919282511 0.999988072382122 1 GO:0160041 neuropeptide activity 1/5575 32/18639 0.03125 0.10447869955157 0.999988624371497 1 GO:0038187 pattern recognition receptor activity 3/5575 48/18639 0.0625 0.208957399103139 0.999991313358419 1 GO:0022824 transmitter-gated monoatomic ion channel activity 5/5575 63/18639 0.0793650793650794 0.265342729019859 0.999995734622465 1 GO:0022835 transmitter-gated channel activity 5/5575 63/18639 0.0793650793650794 0.265342729019859 0.999995734622465 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/5575 69/18639 0.0869565217391304 0.290723337882628 0.999995827114473 1 GO:0003730 mRNA 3'-UTR binding 46/5575 262/18639 0.175572519083969 0.58699483106836 0.999998632089151 1 GO:0015370 solute:sodium symporter activity 7/5575 79/18639 0.0886075949367089 0.296243401260146 0.999998735094837 1 GO:0005125 cytokine activity 39/5575 234/18639 0.166666666666667 0.557219730941704 0.999999098545995 1 GO:0005249 voltage-gated potassium channel activity 10/5575 98/18639 0.102040816326531 0.341154937311247 0.999999322406696 1 GO:0046873 metal ion transmembrane transporter activity 90/5575 450/18639 0.2 0.668663677130045 0.999999457310541 1 GO:0140375 immune receptor activity 21/5575 156/18639 0.134615384615385 0.450062090375992 0.999999615480728 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/5575 73/18639 0.0684931506849315 0.228994409976043 0.99999978493385 1 GO:0005267 potassium channel activity 14/5575 124/18639 0.112903225806452 0.377471430637929 0.999999804459552 1 GO:0015079 potassium ion transmembrane transporter activity 21/5575 160/18639 0.13125 0.438810538116592 0.99999984427545 1 GO:0001653 peptide receptor activity 14/5575 128/18639 0.109375 0.365675448430493 0.999999928580245 1 GO:0005261 monoatomic cation channel activity 60/5575 341/18639 0.175953079178886 0.588267164630538 0.999999949823153 1 GO:0030594 neurotransmitter receptor activity 8/5575 97/18639 0.0824742268041237 0.275737598816513 0.999999959746755 1 GO:0008188 neuropeptide receptor activity 1/5575 48/18639 0.0208333333333333 0.069652466367713 0.999999961969518 1 GO:0008528 G protein-coupled peptide receptor activity 12/5575 122/18639 0.0983606557377049 0.328850988752481 0.999999978986627 1 GO:0015081 sodium ion transmembrane transporter activity 20/5575 164/18639 0.121951219512195 0.407721754347588 0.999999980542008 1 GO:0005216 monoatomic ion channel activity 82/5575 448/18639 0.183035714285714 0.61194666880205 0.99999999515637 1 GO:0099094 ligand-gated monoatomic cation channel activity 13/5575 136/18639 0.0955882352941176 0.319581904510683 0.99999999782373 1 GO:0022836 gated channel activity 46/5575 318/18639 0.144654088050314 0.483624672138083 0.999999999971736 1 GO:0015276 ligand-gated monoatomic ion channel activity 19/5575 186/18639 0.102150537634409 0.341521770577173 0.999999999977458 1 GO:0022834 ligand-gated channel activity 19/5575 188/18639 0.101063829787234 0.337888560251884 0.999999999986578 1 GO:0005179 hormone activity 6/5575 132/18639 0.0454545454545455 0.151969017529556 0.999999999999982 1 GO:0003823 antigen binding 11/5575 174/18639 0.0632183908045977 0.211359208288233 0.999999999999999 1 GO:0030527 structural constituent of chromatin 1/5575 98/18639 0.0102040816326531 0.0341154937311247 0.999999999999999 1 GO:0030371 translation repressor activity 9/5575 329/18639 0.027355623100304 0.0914585576621642 1 1 GO:0045182 translation regulator activity 12/5575 356/18639 0.0337078651685393 0.112696125358996 1 1