category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	69/1862	142/9376	2.44680110739626	SIAH1/TRAF6/UBE2A/CUL1/UBA3/CUL2/UBE2L6/VHL/UBE2B/CUL3/UBE2H/UBE2Q1/BIRC2/HERC2/UBE4A/UBE2W/NEDD4/TRIP12/CDC23/CDC26/MDM2/SMURF2/BIRC3/HERC4/UBE3A/UBE2N/UBE2G1/KLHL9/PIAS1/CUL4B/RCHY1/CDC16/UBE2J1/UBE2J2/RNF7/UBE2D3/UBR5/ANAPC7/PIAS4/NEDD4L/HERC3/UBE3C/SMURF1/UBE3B/HUWE1/BIRC6/FZR1/UBE2E1/ITCH/UBE2E3/UBC/CDC27/UBA6/WWP1/CUL5/ANAPC10/UBE2M/ANAPC5/UBE2S/UBA2/UBE2I/PIAS2/UBE2Z/PIAS3/SKP1/UBOX5/UBE2D2/UBE2F/FANCL	8.64764695007601
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	78/1862	174/9376	2.25726878773288	HSPA5/HERPUD1/HSPH1/DNAJB11/HSPA1A/CALR/DNAJA1/DDIT3/CUL1/HSP90B1/ERO1B/SEC24A/PDIA4/HSPA8/XBP1/HYOU1/HSP90AB1/HSPA1B/DNAJC3/PDIA3/PDIA6/NGLY1/ERO1A/DNAJC10/SEC23A/TRAM1/UBQLN1/EIF2AK3/MAPK8/DDOST/HSP90AA1/EDEM2/BCAP29/SEC24B/EIF2S1/OS9/DNAJA2/UBE2G1/STT3B/CANX/RAD23B/ERN1/ATF6B/DERL1/SEL1L/UBE2J1/EDEM3/UBE2J2/DNAJB12/UBE2D3/RPN1/MBTPS1/DERL2/UGGT2/UBQLN2/UGGT1/BAK1/ATXN3/SAR1B/UFD1/VCP/MOGS/DAD1/UBXN8/PPP1R15A/HSPA6/OSTC/SEC24C/ATF6/HSPA4L/NPLOC4/SEC23B/RNF185/MAN1A2/SKP1/UBE2D2/EDEM1/YOD1	8.33300274649516
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	52/1862	108/9376	2.4244738831205	XPO1/AHCTF1/DDX39B/IPO11/NUP58/NUP54/KPNA1/KPNA4/THOC1/NXF1/THOC7/NMD3/SUMO1/IPO7/NUP153/TNPO1/TMEM33/ACIN1/NUP214/POM121/XPO7/UPF1/NUP98/XPO5/RNPS1/KPNA3/IPO5/XPO4/NUP205/NUP50/PHAX/TNPO3/RAN/DDX19B/IPO8/MAGOH/SUMO2/XPOT/NUP188/NUP155/NUP93/PYM1/RAE1/NUP35/UBE2I/KPNA2/UPF3B/NUP88/NUP160/TNPO2/SENP2/RANBP2	7.41162158521003
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	92/1862	248/9376	1.86798794220574	RHOB/MLKL/TNFSF10/RIPK2/TRAF6/HSP90B1/ARPC5L/CASP1/MAP2K3/NFKB1/CASP7/HSP90AB1/BIRC2/ELMO1/KPNA1/PIK3CA/PIK3C2B/TNFRSF1A/KPNA4/RAF1/ABI1/EXOC5/CASP3/MYL12B/FADD/MAPK8/ARL8A/MYD88/HSP90AA1/ACTR10/LY96/ARL8B/BIRC3/CYTH2/ARPC1B/RAB7A/ARPC1A/AKT1/CASP8/CTNNB1/CASP4/IKBKB/DYNC1LI2/MAPK12/CYCS/WASL/VPS39/RELA/PLEKHM1/ACTR2/PODXL/MAP2K6/SNX18/M6PR/ACTR3/DCTN4/MYO6/NCKAP1/PIK3C3/KPNA3/BAK1/MAPK14/ACBD3/DCTN6/ARF6/TAB3/DYNLT1/CYTH1/TNFRSF10A/IRAK4/PIK3C2A/EXOC7/CDC42/TNFRSF10B/RAB5A/DCTN5/EXOC4/NFKBIA/MAP3K7/VPS11/LEF1/MAPK11/MYL12A/NAIP/CHUK/TUBB2A/ARF1/RIPK1/RHOJ/GCC2/SKP1/FYCO1	6.89591021007657
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	91/1862	250/9376	1.8329022556391	HSPA1A/STAM2/TRAF6/CHMP5/ARPC5L/HSPA8/SPART/CAPZA2/ARFGEF1/HSPA1B/ZFYVE16/HLA-B/SNX3/VPS37B/EPS15L1/RAB8A/HLA-F/IST1/NEDD4/CHMP7/SNX1/RUFY2/VPS26A/SMAD2/EHD1/CLTC/CHMP1B/HLA-A/ARRB1/RUFY1/MDM2/SMURF2/ARFGEF2/VPS4B/ARF4/IGF2R/GRK5/EPS15/CYTH2/ARPC1B/RAB7A/ARAP3/ARPC1A/RAB22A/ZFYVE9/ARFGAP3/HLA-C/PRKCI/TSG101/ARFGAP2/WASL/WASHC2A/RAB10/CHMP4B/RAB11FIP3/ACTR2/SNF8/VTA1/EHD4/SH3GLB1/RAB11FIP5/ACTR3/PIP5K1A/NEDD4L/EHD3/SMURF1/WASHC2C/PDCD6IP/VPS25/SNX2/ITCH/ARF6/GIT2/RAB35/CYTH1/SPG21/CDC42/WWP1/RAB5A/SNX4/HSPA6/VPS36/WASHC4/ARF1/VPS29/EPN2/ARAP1/STAMBP/LDLRAP1/MVB12A/DNAJC6	6.64452120130135
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	71/1862	187/9376	1.91185373671	OAS2/OAS1/OAS3/RIPK2/CARD6/TRAF6/CXCL2/IRF7/PLCB4/GBP4/TBK1/CASP1/NLRP1/NFKB1/HSP90AB1/BIRC2/TRPM7/GBP1/CARD16/ITPR2/STAT1/ERBIN/NEK7/PLCB1/CXCL3/STAT2/ATG5/TICAM1/FADD/GBP2/GABARAPL2/MAPK8/DNM1L/TP53BP1/MYD88/HSP90AA1/MAP1LC3B/BIRC3/CXCL1/TXNIP/CASP8/VDAC3/PKN2/CASP4/IKBKB/MAPK12/ATG12/IFNAR1/RELA/VDAC1/SUGT1/CARD8/VDAC2/ITPR1/TANK/MAPK14/TAB3/IRAK4/IFI16/ATG16L1/ITPR3/NFKBIA/MAP3K7/GBP3/MAPK11/NAIP/CHUK/MFN1/RIPK1/RBCK1/GBP7	6.26977189602496
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	69/1862	180/9376	1.93025420694594	BST2/PPP1CB/OAS2/OAS1/CALR/OAS3/B2M/TRAF6/PIK3R3/IRF7/SRSF7/TBK1/HLA-DQB1/TAP1/NFKB1/BIRC2/PDIA3/PIK3CA/STAT1/SRSF5/HLA-B/TAP2/TNFRSF1A/IFIH1/CGAS/SP100/IFNGR1/HLA-F/SRSF1/NXF1/STAT2/CASP3/SRSF2/TICAM1/FADD/TLR3/MYD88/HLA-A/SRSF9/PILRB/EIF2AK2/BIRC3/EIF2S1/AKT1/CASP8/HLA-C/SRSF3/IKBKB/CYCS/IFNAR1/RELA/IFNGR2/SRSF6/BAK1/HLA-DRB1/SRPK1/IRAK4/JAK2/ITGA5/TSC1/NECTIN2/NFKBIA/MAP3K7/TSC2/ZC3HAV1/CHUK/PPP1CC/MTOR/RHEB	6.27304344240849
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	65/1862	169/9376	1.93670990663472	TRAF6/PIK3R3/HIF1A/TBK1/VMP1/LAMP2/MTMR4/PRKACB/NRAS/PIK3CA/EPG5/CALCOCO2/RAF1/RAB8A/ATG5/ATG3/GABARAPL2/EIF2AK3/MAPK8/PRKAA1/MAP1LC3B/EIF2S1/RAB7A/DDIT4/AKT1/OPTN/ERN1/LAMP1/STX17/C9orf72/STK11/RAB33B/NBR1/VPS39/ATG12/PPP2CA/PLEKHM1/SUPT20H/KRAS/SH3GLB1/PIK3C3/ITPR1/TANK/ATG4B/BIRC6/BECN1/ATG4C/WDFY3/UBC/ZFYVE1/TSC1/PTEN/ATG16L1/MAP3K7/VPS11/TP53INP2/TSC2/ATG2B/BNIP3/PIK3R4/MTOR/CAMKK2/NRBF2/RHEB/GORASP1	6.11687034609681
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	78/1862	216/9376	1.81835541234037	HSPA5/HSPA1A/TNFSF10/TRAF6/ABCG1/PIK3R3/DDIT3/CXCL2/NFATC1/HSPD1/IRF7/PLCB4/HSP90B1/CAMK2D/TBK1/HSPA8/XBP1/CASP1/MAP2K3/NFKB1/CASP7/HSP90AB1/HSPA4/HSPA1B/NRAS/PIK3CA/SELP/TNFRSF1A/ERO1A/PLCB1/CXCL3/CD40/CASP3/TICAM1/EIF2AK3/MAPK8/PTK2/MYD88/HSP90AA1/NOS3/LY96/CXCL1/EIF2S1/SOD2/PPP3R1/AKT1/CASP8/ERN1/MIB1/IKBKB/GSK3B/PPP3CA/MAPK12/CYCS/RELA/PLCG1/NFATC3/MAP2K6/KRAS/VCAM1/ITPR1/TANK/RAP1A/MAPK14/TNFRSF10A/IRAK4/JAK2/CDC42/TNFRSF10B/NFKBIA/MAP3K7/HSPA6/MAPK11/CASP6/ATF6/CHUK/PPP3CB/CALML4	6.05704749282711
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	72/1862	196/9376	1.84975558429602	ZFP36/PIK3R3/CXCL2/NFATC1/IRF7/HIF1A/TBK1/GNB4/NFKB1/CLEC2B/PTGS2/NRAS/PIK3CA/ITPR2/STAT1/PDGFB/HLA-B/TNFRSF1A/RB1/RAF1/IFNGR1/HLA-F/CXCL3/STAT2/CASP3/TICAM1/FADD/ATG3/EP300/MAPK8/TLR3/HLA-A/MAP1LC3B/EIF2AK2/CXCL1/PPP3R1/AKT1/CASP8/HLA-C/CTNNB1/GNG5/IKBKB/GSK3B/PPP3CA/MAPK12/CYCS/IFNAR1/CREB1/RELA/PLCG1/NFATC3/MAP2K6/KRAS/PIK3C3/ITPR1/BAK1/MAPK14/MICB/BECN1/JAK2/UBC/ITPR3/NFKBIA/E2F3/LEF1/MAPK11/CHUK/PPP3CB/CALML4/MTOR/MICA/GNG12	5.98467545023566
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	50/1862	119/9376	2.11573351144969	MLKL/PIK3R3/CXCL2/ADAM17/CYLD/ATF2/MAP2K3/NFKB1/CASP7/BIRC2/PTGS2/CREB5/PIK3CA/TNFRSF1A/CASP10/BAG4/CXCL3/CASP3/CSF1/FADD/MAPK8/DNM1L/BIRC3/CXCL1/TNFRSF1B/AKT1/CASP8/ATF6B/IKBKB/MAPK12/CREB1/RELA/MAP2K6/VCAM1/VEGFC/MAPK14/ITCH/TAB3/EDN1/FRMD8/NFKBIA/MAP3K7/IL15/CX3CL1/MAPK11/JAG1/CHUK/RIPK1/PGAM5/MAP3K8	6.09731605708954
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	60/1862	157/9376	1.92437417474533	PPP1CB/PPID/PIK3R3/NFATC1/MAP2K3/NFKB1/TRPM7/TRAF3IP2/NRAS/PIK3CA/ITPR2/HLA-B/RB1/RAF1/HLA-F/NBN/HIPK1/SMAD2/HLA-A/LIN52/RBL2/MDM2/SIRT1/ETS1/PPP3R1/AKT1/SERPINE1/HLA-C/VDAC3/ATR/PPP3CA/MAPK12/RELA/NFATC3/MAP2K6/KRAS/VDAC1/VDAC2/ITPR1/MAPK14/HUS1/CDK2/MRE11/TSC1/PTEN/ITPR3/HIPK3/E2F3/RBBP4/TSC2/MAPK11/PPP3CB/LIN54/PPP1CC/ATM/GADD45A/CALML4/MTOR/RHEB/RAD1	5.81427546292158
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	78/1862	227/9376	1.73024127341639	CALR/B2M/SOS2/PIK3R3/GNAI3/NFATC1/PLCB4/TBK1/ATF2/GNB4/SOS1/TAP1/NFKB1/PTGS2/PRKACB/NRAS/ARHGEF12/PDIA3/CREB5/ELK1/PIK3CA/ITPR2/HLA-B/TAP2/TNFRSF1A/ADCY4/ITGAV/CGAS/RB1/RAF1/HLA-F/PLCB1/CASP3/FADD/PTK2/HLA-A/ARHGEF11/MDM2/BCAR1/PPP3R1/AKT1/CASP8/HLA-C/ATF6B/CTNNB1/GNG5/GNA13/IKBKB/GSK3B/PPP3CA/MAPK12/CYCS/CREB1/RELA/NFATC3/MAP2K6/KRAS/ITPR1/BAK1/MAPK14/GNAQ/TSC1/SP1/ITPR3/NFKBIA/E2F3/CX3CL1/TSC2/MAPK11/GNAS/CHUK/PPP3CB/RIPK1/PXN/CALML4/MTOR/RHEB/GNG12	5.54411680702851
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	74/1862	214/9376	1.74122890671271	BST2/CALR/B2M/TRAF6/TRIM5/AP1G1/PIK3R3/GNAI3/NFATC1/CUL1/TBK1/GNB4/MAP2K3/TAP1/NFKB1/NRAS/PDIA3/PIK3CA/ITPR2/HLA-B/TAP2/TNFRSF1A/CGAS/RAF1/HLA-F/CASP3/FADD/MAPK8/WEE1/PTK2/MYD88/HLA-A/TNFRSF1B/PPP3R1/AKT1/CASP8/HLA-C/GNG5/CFL2/ATR/IKBKB/PPP3CA/MAPK12/CUL4B/CYCS/RELA/RNF7/PLCG1/NFATC3/SAMHD1/MAP2K6/KRAS/ITPR1/BAK1/MAPK14/IRAK4/AP1S1/PAK4/CUL5/GNAQ/ITPR3/NFKBIA/MAP3K7/MAPK11/CHUK/PPP3CB/RIPK1/AP1S2/ATM/PXN/CALML4/SKP1/MTOR/GNG12	5.46014243334213
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	84/1862	253/9376	1.67184760319772	PPID/RIPK2/TRAF6/PIK3R3/ARHGEF2/PLCB4/CUL1/TBK1/ARPC5L/CASP1/NFKB1/ELMO1/PIK3CA/ITPR2/TECPR1/TNFRSF1A/CALCOCO2/CGAS/TNIP1/PLCB1/DOCK1/FNBP1L/MYL12B/ATG5/MAPK8/PTK2/MYD88/MDM2/BCAR1/MAP1LC3B/CYTH2/HCLS1/ARPC1B/UBE2N/ARPC1A/AKT1/BCL10/CASP4/IKBKB/GSK3B/MAPK12/CYCS/WASL/HK1/ATG12/RELA/UBE2D3/PLCG1/ACTR2/MALT1/VDAC1/ACTR3/PIK3C3/VCL/ITPR1/MAPK14/BECN1/ARF6/TAB3/CYTH1/ITGA5/UBC/TIFA/CDC42/ATG16L1/ITPR3/NFKBIA/MAP3K7/MAPK11/MYL12A/NAIP/CHUK/ARF1/RIPK1/RBCK1/BNIP3/ATM/PRKCE/PXN/U2AF1L4/SKP1/PIK3R4/MTOR/UBE2D2	5.39264804258939
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	103/1862	333/9376	1.55751024923957	MX1/MX2/OASL/SOS2/PIK3R3/ISG15/TBK1/HES4/SOS1/NFKB1/PTGS2/PRKACB/NRAS/CREB5/PIK3CA/STAT1/HLA-B/TNFRSF1A/ITGAV/RB1/RAF1/HLA-F/ATP6V0A1/STAT2/CASP3/PPP2R2D/MAML2/TICAM1/FADD/EP300/UBR4/TLR3/PTK2/HLA-A/RBL2/MDM2/HEY1/PPP2R5A/EIF2AK2/CSNK1A1/CDKN1B/FZD6/COL4A1/HDAC1/UBE3A/ATP6V1C1/AKT1/CASP8/HLA-C/PRKCI/DVL3/APC/LAMB1/ATP6V1E2/CTNNB1/TBPL1/PSEN1/ATR/IKBKB/GSK3B/MAML1/ATP6V1E1/IFNAR1/CREB1/RELA/FZD4/PPP2CA/KRAS/BAK1/PPP2R5E/TADA3/WNT2B/ATP6V1A/NOTCH4/ATP6V1B2/CDK2/ITGA5/LLGL1/PPP2R2A/HES1/PPP2R1B/TBP/CDC42/LAMA5/WNT5B/MFNG/COL4A2/TSC1/PTEN/PPP2R3C/ITGA2/TSC2/NOTCH1/JAG1/GNAS/CHUK/ATM/PXN/ITGA2B/MTOR/RHEB/ATP6V1D/LAMA3	5.15654234321823
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	75/1862	224/9376	1.68597514193647	CALR/B2M/XPO1/ZFP36/PIK3R3/NFATC1/NFYB/HLA-DQB1/KAT2B/ATF2/NFKB1/PRKACB/NRAS/CREB5/ELK1/PIK3CA/HLA-B/TNFRSF1A/ADCY4/RB1/HLA-F/TRRAP/CDC23/CD40/EP300/FOSL1/SMAD2/MAPK8/ELK4/CDC26/HLA-A/MSX1/ETS1/PPP3R1/AKT1/BUB3/CANX/KAT2A/HLA-C/ATF6B/VDAC3/TBPL1/ATR/IKBKB/POLB/STAT5B/PPP3CA/CDC16/RANBP3/CREB1/RELA/NFATC3/IL15RA/ANAPC7/KRAS/VDAC1/RELB/VDAC2/SMAD4/HLA-DRB1/CDK2/RAN/CDC27/TBP/ANAPC10/PTEN/FDPS/NFKBIA/E2F3/IL15/ANAPC5/CHUK/PPP3CB/ATM/RANBP1	5.1726639273676
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	70/1862	205/9376	1.7194205024757	OAS2/OAS1/CALR/OAS3/B2M/TRAF6/PIK3R3/ISG15/IRF7/PSMD12/TBK1/HLA-DQB1/MAP2K3/TAP1/NFKB1/PDIA3/PIK3CA/STAT1/HLA-B/TAP2/POLK/RB1/HLA-F/NEDD4/SAP30/STAT2/CD40/CASP3/FADD/MAPK8/MYD88/HLA-A/SAP30L/MDM2/EIF2AK2/CDKN1B/HDAC1/AKT1/USP7/SIN3A/CASP8/HLA-C/IKBKB/SNW1/MAPK12/CYCS/PSMD11/IFNAR1/RELA/MAP2K6/CD58/RELB/BAK1/MAPK14/PSMC6/HLA-DRB1/PSMC2/PSMC4/CDK2/IRAK4/HES1/NFKBIA/MAP3K7/E2F3/ADRM1/MAPK11/CHUK/RIPK1/NFKBIE/GADD45A	5.18431373373778
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	57/1862	157/9376	1.82815546600806	CALR/ADAM17/NFATC1/ARG2/HIF1A/CAMK2D/CASP1/PECAM1/ATP2A2/CASP7/ATP8A1/PTGS2/ELMO1/ATP11B/ITGAV/DOCK1/DUSP8/CASP3/TMEM30A/PTK2/CD47/BCAR1/SIRT1/RAB7A/SCARF1/S1PR1/LIPA/DNMT3A/PROS1/MAPK12/DUSP5/ANO6/VPS39/CREB1/NFATC3/NR1H2/VPS8/XKR6/MAPK14/ANO5/JAK2/ADAM10/ATP2A3/ATP11A/CPT1A/UQCRFS1/RAB5A/VPS11/CX3CL1/MAPK11/ODC1/PPARD/ATP11C/STAB1/GAS6/GULP1/RAB14	5.20906375042516
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	53/1862	144/9376	1.85332378565461	PSMA2/PIK3R3/PLCB4/PSMD12/XBP1/ATP2A2/OPA1/PIK3CA/ITPR2/PLCB1/MAPK8/NFYA/ATXN2/PSMA3/AKT1/ERN1/VDAC3/TBPL1/PSMA6/ATXN10/PSMA1/CYCS/PSMD11/PSMA5/VDAC1/VDAC2/PIK3C3/PSMB5/ITPR1/KCND3/PSMB2/ATXN3/PSMC6/BECN1/PSMC2/PSMC4/OMA1/RORA/ATP2A3/TBP/ATXN2L/PUM2/GNAQ/SP1/ITPR3/GTF2B/ADRM1/ATG2B/PUM1/PSMD9/PIK3R4/MTOR/NRBF2	5.13673404525716
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	27/1862	56/9376	2.42780420438852	HSPA1A/CXCL2/SEC22B/HSPD1/HSPA8/CLK4/HBS1L/CASP1/NFKB1/CASP7/HSPA1B/CXCL3/CASP3/MYD88/CXCL1/CASP8/CYCS/RELA/SAR1B/VCP/CLK1/NFKBIA/HSPA6/NAIP/ARF1/BCL2L13/BNIP3	5.33451075379313
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	137/1862	480/9376	1.43720014321518	HSPA5/PPID/PSMA2/DDIT3/PLCB4/CAMK2D/PSMD12/TBK1/UBE2L6/XBP1/APP/SDHD/MAP2K3/NFKB1/MT-ND6/ATP2A2/CASP7/PTGS2/NRAS/ITPR2/NDUFA7/TNFRSF1A/RAF1/RAB8A/PLCB1/NDUFB5/CASP3/CSF1/FADD/PRNP/EIF2AK3/LRP6/MAPK8/NDUFC2/CSNK2A1/ACTR10/MAP1LC3B/CSNK1A1/NDUFB3/FZD6/EIF2S1/TNFRSF1B/ATXN2/PPP3R1/UBE2G1/PSMA3/OPTN/CASP8/DVL3/APC/ERN1/VDAC3/DERL1/CTNNB1/PSEN1/PSMA6/GSK3B/PPP3CA/MAPK12/BRAF/C9orf72/HIP1/PSMA1/IFT57/CYCS/UBE2J1/PSMD11/UBE2J2/CSNK2A2/RELA/FZD4/PLCG1/MAP2K6/PSMA5/KRAS/VDAC1/HTT/DCTN4/VDAC2/PIK3C3/NDUFS4/PSMB5/ITPR1/TANK/PSMB2/BAK1/MAPK14/ATXN3/PSMC6/SDHA/BECN1/PSMC2/WNT2B/SDHB/PSMC4/CSNK1E/TOMM40L/DCTN6/ALS2/VCP/UQCRC2/UBC/ATP5F1C/ATP2A3/ZFYVE1/ATXN2L/WNT5B/NDUFC1/GNAQ/UQCRFS1/RAB5A/ITPR3/DCTN5/ATP5MC3/ADRM1/MAPK11/NDUFB6/ATF6/ATG2B/HSD17B10/TUBB2A/PPP3CB/MFN1/NDUFA9/NDUFB8/PINK1/PSMD9/SNCAIP/CALML4/PIK3R4/MTOR/MT-ND4L/NRBF2/COX7B/NDUFAB1/VAPB/NDUFV2	4.89489531610099
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	41/1862	105/9376	1.96622167664058	SIAH1/HIF1A/TBK1/NRAS/OPA1/CALCOCO2/GABARAPL2/EIF2AK3/MAPK8/CSNK2A1/SMURF2/MAP1LC3B/MTX2/EIF2S1/USP15/RHOT1/RAB7A/OPTN/MUL1/ARIH1/NBR1/CSNK2A2/RELA/KRAS/SMURF1/TBC1D15/HUWE1/BECN1/TOMM40L/VCP/UBC/MON1B/RAB5A/SP1/SAMM50/MFN1/BCL2L13/PINK1/BNIP3/PGAM5/MTX3	4.95619079285842
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	55/1862	156/9376	1.77531741441516	RSAD2/IFIT1/MX1/OAS2/OAS1/MX2/OAS3/SOS2/TRAF6/PIK3R3/IRF7/TBK1/SOS1/NFKB1/NRAS/PIK3CA/STAT1/TNFRSF1A/RB1/RAF1/STAT2/CASP3/PPP2R2D/TICAM1/FADD/CLDN14/TLR3/EIF2AK2/EIF2S1/AKT1/CASP8/CTNNB1/IKBKB/GSK3B/YWHAH/BRAF/PIAS1/CYCS/YWHAQ/IFNAR1/RELA/PPP2CA/YWHAG/KRAS/BAK1/CLDN15/CLDN5/CDK2/PPP2R2A/PPP2R1B/NFKBIA/E2F3/CHUK/RIPK1/OCLN	4.86089520801156
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	113/1862	388/9376	1.46650868703423	PPID/PSMA2/PIK3R3/DDIT3/ADAM17/PLCB4/PSMD12/XBP1/APP/SDHD/NFKB1/MT-ND6/ATP2A2/CASP7/PTGS2/NRAS/PIK3CA/ITPR2/NDUFA7/TNFRSF1A/SLC39A1/RAF1/PLCB1/NDUFB5/CASP3/CSF1/FADD/SLC39A8/EIF2AK3/LRP6/MAPK8/NDUFC2/CSNK2A1/SLC39A14/SLC11A2/EIF2AK2/CSNK1A1/NDUFB3/FZD6/EIF2S1/PPP3R1/PSMA3/AKT1/CASP8/DVL3/APC/ERN1/IDE/VDAC3/CTNNB1/PSEN1/PSMA6/IKBKB/GSK3B/PPP3CA/BRAF/NCSTN/PSMA1/CYCS/PSMD11/CSNK2A2/RELA/FZD4/SLC39A9/PSMA5/KRAS/VDAC1/NAE1/VDAC2/PIK3C3/SLC39A10/NDUFS4/PSMB5/ITPR1/PSMB2/PSMC6/SDHA/RTN3/BECN1/PSMC2/WNT2B/SDHB/PSMC4/CSNK1E/UQCRC2/ATP5F1C/ADAM10/ATP2A3/WNT5B/NDUFC1/GNAQ/UQCRFS1/ITPR3/ATP5MC3/ADRM1/NDUFB6/ATF6/ATG2B/HSD17B10/CHUK/TUBB2A/PPP3CB/NDUFA9/NDUFB8/PSMD9/CALML4/PIK3R4/MTOR/MT-ND4L/NRBF2/COX7B/NDUFAB1/NDUFV2	4.67179682735961
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	108/1862	368/9376	1.47779386354084	HSPA5/PSMA2/DDIT3/HNRNPA2B1/PSMD12/SRSF7/TBK1/XBP1/CASP1/SDHD/MAP2K3/MT-ND6/NUP58/NUP54/NDUFA7/TNFRSF1A/RAB8A/NXF1/NDUFB5/UBQLN1/CASP3/HNRNPA3/EIF2AK3/NDUFC2/SETX/ANXA7/ACTR10/NUP153/MAP1LC3B/NDUFB3/EIF2S1/TNFRSF1B/ATXN2/NUP214/PPP3R1/PSMA3/OPTN/ERN1/SRSF3/DERL1/POM121/PSMA6/PPP3CA/MAPK12/C9orf72/PSMA1/CYCS/PSMD11/NUP98/MAP2K6/PSMA5/VDAC1/DCTN4/PIK3C3/UBQLN2/NDUFS4/PSMB5/TANK/PSMB2/MAPK14/PSMC6/SDHA/BECN1/PSMC2/SDHB/NUP205/NUP50/PSMC4/TOMM40L/DCTN6/ALS2/VCP/UQCRC2/ATP5F1C/ATXN2L/NDUFC1/UQCRFS1/RAB5A/ITPR3/DCTN5/ATP5MC3/ADRM1/MAPK11/NUP188/NDUFB6/NUP155/NUP93/ATF6/ATG2B/TUBB2A/PPP3CB/RAE1/NUP35/NDUFA9/NDUFB8/PINK1/PSMD9/NUP88/PIK3R4/MTOR/MT-ND4L/NUP160/NRBF2/COX7B/NDUFAB1/VAPB/NDUFV2/RANBP2	4.65468364349406
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	66/1862	200/9376	1.66169709989259	TNFSF10/TRAF6/ARHGEF2/BAIAP2L1/NCK1/SEC24A/ARPC5L/CASP1/NFKB1/CASP7/ARHGEF12/TNFRSF1A/ABI1/MYO5C/CASP3/FADD/CLDN14/MAPK8/MYD88/ARHGEF11/SEC24B/CYTH2/HCLS1/ARPC1B/ARPC1A/CASP8/CASP4/GNA13/IKBKB/MAPK12/CYCS/WASL/RELA/ACTR2/ACTR3/MYO6/NCKAP1/TMBIM6/BAK1/CLDN15/CLDN5/MAPK14/ARF6/TAB3/CYTH1/TNFRSF10A/IRAK4/MYO1E/BAIAP2/CDC42/TNFRSF10B/NFKBIA/MAP3K7/MAPK11/NCK2/SEC24C/MYO5A/MYH9/NAIP/CHUK/TUBB2A/ARF1/RIPK1/TJP1/OCLN/MYO1D	4.70855239829462
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	22/1862	44/9376	2.51772287862513	TAF13/GTF2H2/GTF2I/GTF2A2/GTF2H1/GTF2A1/MNAT1/TBPL1/TAF1/TAF11/TAF7/CCNH/GTF2H5/TBP/TAF12/GTF2E1/GTF2B/TAF9/ERCC3/TAF8/TAF5L/GTF2H3	5.02309434437326
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	36/1862	90/9376	2.01417830290011	TRAF6/PIK3R3/NFATC1/HIF1A/MAP2K3/NFKB1/NRAS/PIK3CA/STAT1/RAF1/IFNGR1/TICAM1/MYD88/CSNK2A1/PPP3R1/AKT1/IKBKB/PPP3CA/MAPK12/CSNK2A2/RELA/PLCG1/NFATC3/MAP2K6/IFNGR2/KRAS/MAPK14/JAK2/PTEN/NFKBIA/MAPK11/CHUK/PPP3CB/NFKBIE/BATF3/MTOR	4.81239327613838
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	58/1862	173/9376	1.68818412670818	RSAD2/MX1/OAS2/OAS1/MX2/OAS3/TNFSF10/XPO1/PIK3R3/IRF7/TBK1/HLA-DQB1/CASP1/NFKB1/DNAJC3/KPNA1/PIK3CA/STAT1/TNFRSF1A/CALCOCO2/IFIH1/RAF1/IFNGR1/NXF1/PABPN1/STAT2/CASP3/ADAR/TICAM1/FADD/EP300/TLR3/MYD88/EIF2AK2/EIF2S1/AKT1/CASP8/CIITA/IKBKB/CYCS/IFNAR1/RELA/NUP98/TRIM25/IFNGR2/VDAC1/IL33/BAK1/HLA-DRB1/TNFRSF10A/IRAK4/JAK2/TNFRSF10B/FDPS/NFKBIA/CHUK/RAE1/KPNA2	4.54781587061199
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	30/1862	72/9376	2.09810239885428	TRAF6/ISG15/IRF7/CYLD/TBK1/NFKB1/IFIH1/CASP10/AZI2/DHX58/ATG5/ADAR/FADD/MAPK8/SIKE1/CASP8/IKBKB/MAPK12/ATG12/RELA/TRIM25/DDX3X/TANK/MAPK14/NFKBIA/MAP3K7/MAPK11/CHUK/RNF125/RIPK1	4.65601229846576
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	55/1862	163/9376	1.69907678925623	SOS2/TRAF6/PIK3R3/NFATC1/IRF7/TBK1/ATF2/SOS1/MAP2K3/NFKB1/NRAS/CREB5/ELK1/PIK3CA/STAT1/IFIH1/CASP10/RB1/RAF1/STAT2/CASP3/TICAM1/FADD/EP300/MAPK8/TLR3/EGR3/MYD88/AKT1/CASP8/ATF6B/VDAC3/IKBKB/STAT5B/MAPK12/BRAF/CYCS/YWHAQ/IFNAR1/CREB1/RELA/NFATC3/MAP2K6/KRAS/DDX3X/SMAD4/MAPK14/CDK2/IRAK4/JAK2/NFKBIA/MAP3K7/E2F3/MAPK11/CHUK	4.48185736187315
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	48/1862	138/9376	1.75145939382618	TRAF6/PIK3R3/NFATC1/TBK1/ARPC5L/CASP1/MAP2K3/NFKB1/ELMO1/ARHGEF12/PIK3CA/DOCK1/TICAM1/MAPK8/PTK2/MYD88/RPS6KA3/BCAR1/ARPC1B/ARPC1A/AKT1/PKN2/IKBKB/GSK3B/MAPK12/ARHGEF7/WASL/RELA/PLCG1/NFATC3/ACTR2/MAP2K6/ACTR3/PIP5K1A/MAPK14/ARF6/GIT2/IRAK4/ITGA5/BAIAP2/CDC42/GNAQ/NFKBIA/MAP3K7/MAPK11/CHUK/PXN/SKAP2	4.4268617905849
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	29/1862	71/9376	2.05673136563743	F11R/CXCL2/ADAM17/NFKB1/HBEGF/ATP6V0A1/CXCL3/CASP3/MAPK8/CXCL1/ATP6V1C1/ATP6V1E2/IKBKB/MAPK12/ATP6V1E1/RELA/PLCG1/JAM2/MAPK14/ATP6V1A/ATP6V1B2/ADAM10/CDC42/JAM3/NFKBIA/MAPK11/CHUK/TJP1/ATP6V1D	4.44913378382382
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	49/1862	144/9376	1.71345029239766	TRA2A/TRAF6/CXCL2/TBK1/MAP2K3/NFKB1/TNFRSF1A/ACADM/ADIPOR2/CXCL3/CASP3/TICAM1/FADD/MAPK8/PRKAA1/MYD88/LY96/SIRT1/CXCL1/AKT1/ACADVL/CASP8/CTNNB1/IKBKB/GSK3B/MAPK12/ACACA/ADH5/RELA/ACACB/MAP2K6/ADIPOR1/ALDH9A1/SREBF1/MAPK14/TAB3/ACOX1/IRAK4/CPT1A/NFKBIA/ALDH3A2/MAP3K7/LEF1/MAPK11/CHUK/RIPK1/TRA2B/MLYCD/CAMKK2	4.29474071644018
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	26/1862	62/9376	2.11163854336302	TLE1/ADAM17/DTX3L/DLL4/KAT2B/NUMB/MAML2/NRARP/EP300/DLL1/HEY1/HDAC1/SPEN/KAT2A/DVL3/PSEN1/MAML1/SNW1/CTBP2/NCSTN/NOTCH4/ITCH/HES1/MFNG/NOTCH1/JAG1	4.37150727610017
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	32/1862	83/9376	1.94137667749408	OGT/SCML1/CBX4/PCGF5/EP300/KDM2A/RNF2/MBD5/HDAC1/USP7/PHF1/MTF2/FBRS/MGA/LCOR/UBE2D3/PCGF3/FOXK1/PHC3/MBD6/ASXL2/BCOR/E2F6/RBBP4/RYBP/AEBP2/PHC2/SUZ12/WDR5/SKP1/EZH1/UBE2D2	4.28809495032679
Human Diseases	Infectious disease: viral	hsa05162	Measles	46/1862	136/9376	1.703165476717	MX1/OAS2/HSPA1A/OAS1/MX2/CD46/OAS3/TRAF6/PIK3R3/IRF7/TBK1/HSPA8/NFKB1/HSPA1B/BBC3/PIK3CA/STAT1/IFIH1/STAT2/CASP3/ADAR/FADD/MAPK8/MYD88/CSNK2A1/EIF2AK2/CDKN1B/EIF2S1/AKT1/CASP8/IKBKB/GSK3B/STAT5B/RCHY1/CYCS/CSNK2A2/IFNAR1/RELA/BAK1/MSN/CDK2/IRAK4/NFKBIA/MAP3K7/HSPA6/CHUK	4.11178965728776
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	37/1862	103/9376	1.80884944677922	PPP1CB/DDX39B/HBS1L/RNMT/ETF1/RNGTT/NXF1/PABPN1/PPP2R2D/PELO/PPP2R5A/PAPOLA/ACIN1/SMG1/UPF1/WDR33/CPSF6/PPP2CA/RNPS1/MSI2/PCF11/PPP2R5E/PPP2R2A/PAPOLG/PPP2R1B/CPSF7/NUDT21/DDX19B/PPP2R3C/MAGOH/PYM1/DAZAP1/PPP1CC/UPF3B/CSTF3/CPSF1/GSPT1	4.10880997513394
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	46/1862	137/9376	1.69073361192345	TNFSF10/IL3RA/PIK3R3/DDIT3/MCL1/NFKB1/PARP4/CASP7/BIRC2/NRAS/BBC3/PIK3CA/ITPR2/TNFRSF1A/CASP10/RAF1/CASP3/FADD/EIF2AK3/MAPK8/BIRC3/PMAIP1/EIF2S1/AKT1/CASP8/ERN1/IKBKB/PARP2/CYCS/RELA/KRAS/SPTAN1/ITPR1/BAK1/CASP2/TNFRSF10A/TNFRSF10B/ITPR3/NFKBIA/CASP6/CHUK/RIPK1/CTSC/ATM/AIFM1/GADD45A	4.05413560375252
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	34/1862	93/9376	1.84091565318827	YES1/CDH5/FARP2/MYL12B/EP300/CSNK2A1/SMURF2/HEG1/CTNND1/SSX2IP/CTNNB1/WASL/AFDN/CSNK2A2/NLK/SMURF1/PTPRM/SMAD4/FER/VCL/RAP1A/PDCD10/PTPRB/BAIAP2/CDC42/NECTIN2/MAP3K7/LEF1/SNAI1/MYL12A/CTNNA1/ACP1/TJP1/CCM2	4.05685622818864
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	39/1862	112/9376	1.75341414761393	HSPA1A/TRAF6/GNAI3/HSPA8/HLA-DQB1/MAP2K3/NFKB1/BIRC2/HSPA1B/STAT1/TNFRSF1A/IFNGR1/CD40/CASP3/MAPK8/MYD88/LY96/BIRC3/AKT1/CASP8/LAMB1/CIITA/IKBKB/MAPK12/CYCS/RELA/MAP2K6/IFNGR2/MAPK14/HLA-DRB1/IRAK4/JAK2/LAMA5/NFKBIA/MAP3K7/HSPA6/MAPK11/CHUK/LAMA3	3.99285363282743
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	37/1862	105/9376	1.77439517160248	PIK3R3/NFATC1/CYLD/CASP1/NFKB1/PTGS2/NRAS/ARHGEF12/PIK3CA/ITPR2/STAT1/PLK3/RAF1/STAT2/MAPK8/EGR3/MDM2/PPP3R1/AKT1/BCL10/CASP8/IKBKB/PPP3CA/MAPK12/RELA/NFATC3/MALT1/KRAS/RELB/ITPR1/MAPK14/ITPR3/NFKBIA/MAPK11/CHUK/PPP3CB/CALML4	3.9722253312248
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	34/1862	94/9376	1.8213314441118	TRAF6/CXCL2/HSP90B1/TBK1/NFKB1/HSP90AB1/PTGS2/TRAF3IP2/ELAVL1/SRSF1/CXCL3/CASP3/FADD/FOSL1/MAPK8/USP25/HSP90AA1/CXCL1/MAPK6/CASP8/IKBKB/GSK3B/MAPK12/RELA/MAPK7/FOSB/MAPK14/TAB3/JUND/NFKBIA/MAP3K7/MAPK11/ANAPC5/CHUK	3.98383621951267
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	73/1862	250/9376	1.47035016111708	LAPTM4B/OSTM1/AP1G1/HYAL2/LAMP2/AP3M1/NPC1/SCARB2/SLC15A3/SORT1/VPS13C/ATP6V0A1/NEU1/BLOC1S2/VPS26A/TLR3/CLTC/ARL8A/SLC11A2/SLC2A6/IGF2R/ARL8B/OSBP/RAB7A/ATP6V1C1/SLC36A4/ATP6V1E2/GNS/VPS13A/LIPA/LAMP3/GALC/CD164/LAMP1/STX17/OSBPL2/ATP6V1E1/VPS39/PLEKHM1/CTNS/M6PR/GGA1/PPT2/KXD1/LAMTOR3/ENTPD4/ATP6V1A/ATP6V1B2/AP3S1/BLOC1S6/LGMN/SNAPIN/MAN2B1/AP1S1/TTI1/NAGA/HYAL1/MANBA/CLN8/VPS11/AP4M1/PIKFYVE/VPS29/AP1S2/DTNBP1/FUCA1/GNPTG/CTSC/MTOR/CLCN7/BLOC1S4/ATP6V1D/BORCS5	3.75224295098095
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	16/1862	34/9376	2.36962153282366	PER1/CUL1/BHLHE40/NR1D2/NR1D1/PRKAA1/NPAS2/FBXL3/CREB1/CSNK1E/CRY2/RORA/CRY1/CSNK1D/PER3/SKP1	3.98253850501719
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/1862	105/9376	1.72643854534295	TRAF6/CXCL2/CYLD/NFKB1/BIRC2/PTGS2/TNFRSF1A/CXCL3/CD40/TICAM1/MYD88/CSNK2A1/LY96/BIRC3/CXCL1/BCL10/IKBKB/ERC1/CSNK2A2/RELA/TRIM25/PLCG1/MALT1/PIAS4/VCAM1/RELB/TAB3/IRAK4/NFKBIA/MAP3K7/CARD10/CHUK/UBE2I/RIPK1/ATM/GADD45A	3.72623396581639
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	43/1862	133/9376	1.62800125986287	KLF2/TNFSF10/SOS2/PLK2/PIK3R3/SOS1/NRAS/PIK3CA/PLK3/RAF1/EP300/GABARAPL2/MAPK8/PRKAA1/RBL2/MDM2/SIRT1/CDKN1B/DEPP1/SOD2/PRMT1/AKT1/USP7/S1PR1/IKBKB/MAPK12/BRAF/STK11/ATG12/NLK/KRAS/SMAD4/MAPK14/CSNK1E/S1PR4/CDK2/PTEN/SETD7/MAPK11/CHUK/BNIP3/ATM/GADD45A	3.63094558243743
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	40/1862	122/9376	1.65096582204927	SOS2/PIK3R3/NFATC1/NCK1/SOS1/NFKB1/NRAS/PIK3CA/RAF1/PPP2R2D/MAPK8/PPP2R5A/PPP3R1/AKT1/BCL10/IKBKB/GSK3B/PPP3CA/MAPK12/RELA/PLCG1/NFATC3/PPP2CA/MALT1/KRAS/PPP2R5E/MAPK14/PPP2R2A/PPP2R1B/CDC42/PAK4/PPP2R3C/NFKBIA/MAP3K7/MAPK11/NCK2/CHUK/PPP3CB/NFKBIE/MAP3K8	3.60257670225043
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	40/1862	122/9376	1.65096582204927	PIK3R3/PLCB4/HIF1A/KAT2B/ATP2A2/PRKACB/NRAS/PIK3CA/STAT1/ITGAV/MED12/RAF1/PLCB1/EP300/MED13/MDM2/TBC1D4/HDAC1/MED30/AKT1/SIN3A/MED13L/KAT2A/NCOA3/CTNNB1/GSK3B/ATP1A1/PLCG1/KRAS/NCOA1/MED17/NOTCH4/NCOA2/ATP2A3/SLC16A2/TSC2/NOTCH1/SLC9A1/MTOR/RHEB	3.60257670225043
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	27/1862	73/9376	1.86242514309256	BST2/MX1/MX2/TRIM5/XPO1/KAT2B/CCNT2/FURIN/EP300/AFF4/NUP153/VPS4B/NELFA/KAT2A/TSG101/CDK9/CPSF6/CHMP4B/SAMHD1/MDFIC/PDCD6IP/MLLT3/TNPO3/RAN/CPSF7/NELFCD/RANBP2	3.68223252818054
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/1862	78/9376	1.80759591285907	HSPD1/PNPT1/TOB1/DDX6/CNOT9/CNOT2/C1D/PATL1/LSM6/XRN1/BTG2/TOB2/LSM8/DCP1A/HSPA9/CNOT4/DCP2/LSM1/CNOT1/PAN3/CNOT6L/CNOT7/CNOT6/DCP1B/TENT4A/BTG3/EXOSC1/LSM5	3.56522155815788
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	32/1862	93/9376	1.73262649711837	TRAF6/PIK3R3/NFKB1/BIRC2/PTGS2/PIK3CA/ITGAV/POLK/RB1/CKS2/CASP3/PTK2/BIRC3/CDKN1B/COL4A1/AKT1/LAMB1/IKBKB/CYCS/RELA/BAK1/CDK2/LAMA5/COL4A2/PTEN/NFKBIA/E2F3/ITGA2/CHUK/GADD45A/ITGA2B/LAMA3	3.53443339590833
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/1862	30/9376	2.34987468671679	SDHD/DLST/SUCLA2/FH/PDHB/IDH1/ACO2/IDH3A/SDHA/SDHB/DLD/MDH1/ACLY/PDHA1	3.68621849306301
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	40/1862	125/9376	1.61134264232009	PIK3R3/GNAI3/PLCB4/NFKB1/NRAS/PIK3CA/CERS2/ORMDL1/TNFRSF1A/RAF1/PLCB1/PPP2R2D/MAPK8/ABCC1/NOS3/PPP2R5A/AKT1/S1PR1/GNA13/MAPK12/SPTLC2/FCER1A/RELA/PPP2CA/KRAS/PPP2R5E/MAPK14/S1PR4/NSMAF/PPP2R2A/PPP2R1B/SPTLC1/GNAQ/PTEN/PPP2R3C/DEGS1/MAPK11/PRKCE/SGMS1/SPTLC3	3.42519449148431
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	39/1862	122/9376	1.60969167649804	SOS2/PIK3R3/GNAI3/PLCB4/ATF2/SOS1/MAP2K3/PRKACB/NRAS/CREB5/PIK3CA/ITPR2/STAT1/ADCY4/RAF1/PLCB1/EP300/MAPK8/PTK2/BCAR1/SHC1/AKT1/ATF6B/GSK3B/STAT5B/MAPK12/CREB1/PLCG1/MAP2K6/KRAS/ITPR1/MAPK14/SOCS2/JAK2/GNAQ/ITPR3/MAPK11/GNAS/MTOR	3.37415722133196
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	59/1862	205/9376	1.44922585208666	PIK3R3/IRF7/KAT2B/ATF2/GTF2H2/NFKB1/PRKACB/NRAS/CREB5/PIK3CA/HLA-B/RB1/SP100/HLA-F/CASP3/EP300/GTF2A2/GTF2H1/UBR4/EGR3/HLA-A/RBL2/MDM2/EIF2AK2/CDKN1B/PMAIP1/HDAC1/UBE3A/USP7/GTF2A1/KAT2A/CASP8/HLA-C/ATF6B/VDAC3/HNRNPK/TBPL1/POLB/YWHAH/STAT5B/SNW1/YWHAQ/CREB1/RELA/YWHAG/KRAS/DDX3X/DNAJA3/BAK1/HDAC9/CDK2/TBP/CDC42/GTF2E1/NFKBIA/GTF2B/GTF2H3/PXN/RANBP1	3.23722738858363
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	27/1862	77/9376	1.76567578500983	SOS2/PIK3R3/MECOM/SOS1/NFKB1/NRAS/PIK3CA/POLK/RB1/RAF1/MDM2/SHC1/CDKN1B/HDAC1/AKT1/IKBKB/STAT5B/BRAF/CTBP2/RELA/KRAS/SMAD4/BAK1/NFKBIA/E2F3/CHUK/GADD45A	3.35824233644917
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	27/1862	78/9376	1.74303891597125	SYNJ2/PLCB4/MTMR4/PIK3CA/PIK3C2B/MINPP1/PLCB1/MTMR6/IPPK/MTMR2/IMPA1/PI4KB/IP6K2/MTM1/INPP1/SYNJ1/PLCG1/PIP5K1A/PIK3C3/PIK3C2A/PIP4K2A/INPP5K/PTEN/IP6K1/PIKFYVE/ALDH6A1/IPMK	3.28022754893911
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1862	32/9376	2.20300751879699	CASP7/BIRC2/BBC3/TNFRSF1A/CASP3/FADD/MAPK8/BIRC3/PMAIP1/CASP8/CYCS/BAK1/BIRC6/BECN1	3.39325733944769
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	32/1862	98/9376	1.6442271860409	PIK3R3/SYNJ2/PLCB4/MTMR4/PIK3CA/ITPR2/PIK3C2B/PLCB1/MTMR6/IPPK/MTMR2/IMPA1/PI4KB/IP6K2/MTM1/INPP1/SYNJ1/DGKE/PLCG1/DGKZ/PIP5K1A/PIK3C3/ITPR1/PIK3C2A/PIP4K2A/PTEN/ITPR3/IP6K1/PIKFYVE/CDS2/IPMK/CALML4	3.19127906171161
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	43/1862	142/9376	1.52481808142086	KLF2/DUSP1/PIK3R3/ARHGEF2/HSP90B1/SDC4/PECAM1/NFKB1/HSP90AB1/CDH5/PIK3CA/PDGFB/NQO1/TNFRSF1A/ITGAV/MAPK8/PRKAA1/SUMO1/PTK2/HSP90AA1/NOS3/AKT1/CTNNB1/MGST2/IKBKB/MAPK12/RELA/MAP2K6/PIAS4/VCAM1/MAPK7/MAPK14/EDN1/GSTO2/GSTO1/MAP3K7/KDR/SUMO2/MAPK11/CHUK/ACVR1/CALML4/ITGA2B	3.13688001615608
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	73/1862	268/9376	1.37159529954951	HSPA5/DUSP1/PSMA2/GNAI3/DDIT3/CAMK2D/PSMD12/UBE2L6/XBP1/SDHD/MT-ND6/PRKACB/ITPR2/NDUFA7/SLC39A1/NDUFB5/CASP3/SLC39A8/EIF2AK3/MAPK8/NDUFC2/SLC39A14/SLC11A2/NDUFB3/EIF2S1/UBE2G1/PSMA3/ERN1/VDAC3/PSMA6/PSMA1/CYCS/UBE2J1/PSMD11/UBE2J2/PLCG1/SLC39A9/PSMA5/VDAC1/VDAC2/SLC39A10/NDUFS4/PSMB5/ITPR1/PSMB2/PSMC6/SDHA/PSMC2/SDHB/PSMC4/UQCRC2/UBC/ATP5F1C/NDUFC1/UQCRFS1/ITPR3/ATP5MC3/ADRM1/NDUFB6/ATF6/GNAS/TUBB2A/MFN1/NDUFA9/NDUFB8/PINK1/PSMD9/SNCAIP/CALML4/MT-ND4L/COX7B/NDUFAB1/NDUFV2	3.07231668209279
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1862	106/9376	1.61514297874065	SOS2/PIK3R3/HSP90B1/SOS1/NFKB1/PDGFD/HSP90AB1/NRAS/CREB5/PIK3CA/PDGFB/RB1/RAF1/FOLH1/EP300/HSP90AA1/MDM2/CDKN1B/AKT1/CTNNB1/IKBKB/GSK3B/BRAF/CREB1/RELA/KRAS/NKX3-1/CDK2/PTEN/NFKBIA/E2F3/LEF1/CHUK/MTOR	3.17050920223077
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	32/1862	99/9376	1.62761883062635	SOS2/PIK3R3/DLL4/SOS1/HBEGF/PRKACB/NRAS/ESR2/PIK3CA/ADCY4/RB1/RAF1/DLL1/MAPK8/PTK2/MDM2/SHC1/CDKN1B/AKT1/NCOA3/MAPK12/BRAF/KRAS/MAPK14/NOTCH4/SP1/E2F3/MAPK11/NOTCH1/JAG1/GNAS/MTOR	3.12499743729644
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	33/1862	103/9376	1.61329815523552	CALR/TRAF6/PIK3R3/GNAI3/PLCB4/NFKB1/PIK3CA/TNFRSF1A/IFNGR1/PLCB1/PPP2R2D/TICAM1/FADD/SMAD2/MAPK8/MYD88/AKT1/SERPINE1/CASP8/IKBKB/MAPK12/RELA/PPP2CA/IFNGR2/MAPK14/IRAK4/PPP2R2A/PPP2R1B/GNAQ/NFKBIA/MAPK11/GNAS/CHUK	3.11544452184163
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	80/1862	300/9376	1.34278553526674	HSPA1A/DUSP1/SOS2/TRAF6/DDIT3/NFATC1/HSPA8/MECOM/ATF2/MAP3K13/SOS1/MAP2K3/NFKB1/PDGFD/HSPA1B/PRKACB/RASGRF1/NRAS/PLA2G4A/TEK/ELK1/PDGFB/TNFRSF1A/RAF1/DUSP8/CASP3/CSF1/FGF18/MAPK8/ELK4/CDC25B/MYD88/RPS6KA3/ARRB1/NF1/MKNK2/PPP3R1/AKT1/KITLG/MAP3K12/MAP4K3/EPHA2/IKBKB/PPP3CA/MAPK12/BRAF/DUSP5/NR4A1/RELA/NFATC3/PLA2G4C/MAP2K6/NLK/KRAS/RELB/MAPK7/STMN1/VEGFC/MAP3K11/RAP1A/LAMTOR3/MAPK14/MAP3K6/IRAK4/JUND/STK3/MAPKAPK5/CDC42/DUSP6/MAP3K7/KDR/HSPA6/MAPK11/CHUK/PPP3CB/RASA1/GADD45A/MAP3K8/RASGRF2/GNG12	3.00383278026671
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	37/1862	120/9376	1.55259577515217	RIPK2/SOS2/TRAF6/PIK3R3/CAMK2D/IRAK2/SOS1/NFKB1/NRAS/PIK3CA/SORT1/RAF1/MAPK8/RPS6KA3/SHC1/ZNF274/AKT1/PSEN1/IKBKB/GSK3B/MAPK12/BRAF/KIDINS220/RELA/PLCG1/IRAK3/KRAS/MAPK7/SH2B3/RAP1A/MAPK14/IRAK4/CDC42/NFKBIA/MAPK11/NFKBIE/CALML4	3.03267863305842
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	46/1862	157/9376	1.47535353397142	PIK3R3/DDIT3/XBP1/SDHD/NFKB1/CASP7/PIK3CA/NDUFA7/TNFRSF1A/ADIPOR2/NDUFB5/CASP3/EIF2AK3/MAPK8/PRKAA1/NDUFC2/NDUFB3/EIF2S1/AKT1/CASP8/ERN1/IKBKB/GSK3B/MAPK12/CYCS/LEPR/RELA/ADIPOR1/NDUFS4/SREBF1/MAP3K11/MAPK14/SDHA/SDHB/ITCH/UQCRC2/CDC42/NDUFC1/UQCRFS1/MAPK11/NDUFB6/NDUFA9/NDUFB8/COX7B/NDUFAB1/NDUFV2	2.98995413793828
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	30/1862	93/9376	1.62433734104847	NFATC1/DLL4/HLA-DQB1/NFKB1/STAT1/IFNGR1/MAML2/DLL1/MAPK8/PPP3R1/IKBKB/MAML1/STAT5B/PPP3CA/MAPK12/RELA/PLCG1/NFATC3/IFNGR2/MAPK14/HLA-DRB1/JAK2/NFKBIA/MAPK11/NOTCH1/JAG1/CHUK/PPP3CB/IL4R/NFKBIE	3.01201056362803
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	36/1862	117/9376	1.54936792530778	PHF10/SMARCE1/PHF6/ARID2/TRRAP/SS18L1/CDK2AP1/RUVBL1/MTA3/HDAC1/ING3/CDK2AP2/EPC2/EP400/INO80/MTA2/MORF4L2/BICRA/BCL7B/UCHL5/SS18/BRD7/MBD2/MEAF6/INO80D/EPC1/DPF2/MRGBP/RBBP4/SMARCA2/ARID1B/SMARCA1/SRCAP/POLE3/BAZ2B/YEATS4	2.97655608224788
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	24/1862	71/9376	1.70212250949305	SOS2/PIK3R3/SOCS4/SOS1/NFKB1/NRAS/ESR2/PIK3CA/STAT1/RAF1/MAPK8/SHC1/AKT1/GSK3B/STAT5B/MAPK12/RELA/KRAS/GALT/MAPK14/SOCS2/JAK2/SOCS5/MAPK11	2.95613159498142
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	21/1862	60/9376	1.76240601503759	PIK3R3/PTGS2/NRAS/PLA2G4A/PIK3CA/RAF1/PTK2/NOS3/PPP3R1/AKT1/PPP3CA/MAPK12/PLCG1/PLA2G4C/KRAS/MAPK14/CDC42/KDR/MAPK11/PPP3CB/PXN	2.94908357579112
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	16/1862	42/9376	1.91826505038105	ACSL3/CP/ATG5/SLC39A8/PRNP/SLC39A14/SLC11A2/MAP1LC3B/SLC3A2/VDAC3/SLC7A11/VDAC2/ACSL4/ACSL5/LPCAT3/GCLM	2.96892128467797
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/1862	46/9376	1.86092560594032	PSMA2/PSMD12/PSME4/PSMA3/PSMB9/PSMA6/PSMA1/PSMD11/PSMA5/PSMB8/PSMB5/PSMB2/PSMC6/PSMC2/PSMC4/ADRM1/PSMD9	2.91369172176262
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/1862	158/9376	1.43414594352065	CUL1/CDC14A/RB1/STAG2/CDC23/EP300/SMAD2/PDS5B/CDC26/WEE1/CDC25B/RBL2/MDM2/PPP2R5A/CDKN1B/HDAC1/BUB3/ATR/GSK3B/YWHAH/MCM7/CDC16/YWHAQ/PPP2CA/ESCO1/ANAPC7/WAPL/CCNH/YWHAG/SMAD4/NIPBL/PPP2R5E/FZR1/CDK2/CDC27/ORC4/PPP2R1B/ANAPC10/E2F3/TFDP2/ANAPC5/ATM/GADD45A/MTBP/SKP1	2.73959156419848
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	45/1862	158/9376	1.43414594352065	SOS2/PIK3R3/RICTOR/SOS1/NRAS/PIK3CA/TNFRSF1A/RAF1/EIF4E/MAPKAP1/CAB39/LRP6/PRKAA1/RPS6KA3/FZD6/ATP6V1C1/DDIT4/AKT1/DVL3/SLC3A2/ATP6V1E2/IKBKB/GSK3B/FNIP1/BRAF/STK11/ATP6V1E1/FZD4/WDR59/KRAS/LAMTOR3/WNT2B/ATP6V1A/ATP6V1B2/TTI1/WNT5B/TSC1/PTEN/NPRL2/TSC2/CHUK/MTOR/WDR24/RHEB/ATP6V1D	2.73959156419848
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	13/1862	32/9376	2.04564983888292	HIBCH/SUCLA2/ACACA/PCCA/ACACB/ECHS1/ECHDC1/ACOX1/DLD/DBT/ALDH6A1/ACSS2/MLYCD	2.94940716067172
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1862	32/9376	2.04564983888292	ATG5/ATG3/GABARAPL2/ATG12/PPP2CA/PIK3C3/ATG4B/BECN1/ATG4C/ATG16L1/ATG2B/PIK3R4/MTOR	2.94940716067172
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	72/1862	275/9376	1.31837125280734	HSPA5/HSPA1A/PSMA2/STIP1/PIK3R3/DDIT3/PSMD12/HSPA8/ATF2/SDHD/MT-ND6/HSPA1B/PRKACB/CREB5/PIK3CA/ITPR2/NDUFA7/NDUFB5/CASP3/PRNP/EIF2AK3/MAPK8/NDUFC2/CSNK2A1/NDUFB3/EIF2S1/PPP3R1/PSMA3/ATF6B/VDAC3/PSMA6/GSK3B/PPP3CA/MAPK12/PSMA1/CYCS/PSMD11/CSNK2A2/CREB1/PSMA5/VDAC1/VDAC2/NDUFS4/PSMB5/ITPR1/PSMB2/MAPK14/PSMC6/SDHA/PSMC2/SDHB/PSMC4/UQCRC2/ATP5F1C/NDUFC1/UQCRFS1/ITPR3/ATP5MC3/HSPA6/ADRM1/MAPK11/NOTCH1/NDUFB6/TUBB2A/PPP3CB/NDUFA9/NDUFB8/PSMD9/MT-ND4L/COX7B/NDUFAB1/NDUFV2	2.66744526912891
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	33/1862	109/9376	1.52449275219504	NFATC1/HIF1A/HLA-DQB1/IL27RA/NFKB1/HSP90AB1/STAT1/IFNGR1/SMAD2/MAPK8/HSP90AA1/AHR/PPP3R1/IKBKB/STAT5B/PPP3CA/MAPK12/RELA/PLCG1/NFATC3/IFNGR2/SMAD4/MAPK14/HLA-DRB1/RORA/JAK2/NFKBIA/MAPK11/CHUK/PPP3CB/IL4R/NFKBIE/MTOR	2.74171961935577
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	31/1862	101/9376	1.54553285618573	PIK3R3/NFATC1/PLCB4/NFKB1/NRAS/PIK3CA/STAT1/PLCB1/CASP3/SMAD2/MAPK8/NOS3/CDKN1B/COL4A1/AKT1/SERPINE1/STAT5B/MAPK12/RELA/PLCG1/KRAS/VCAM1/SMAD4/VEGFC/MAPK14/EDN1/JAK2/CDC42/COL4A2/MAPK11/PRKCE	2.74387625357217
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	27/1862	85/9376	1.59949453465597	CMPK2/CANT1/NTPCR/NT5C3A/HPRT1/GMPR/GMPR2/AK6/DTYMK/NT5E/DUT/DCK/CDA/PNP/CMPK1/DGUOK/ENTPD4/NT5C2/DCTPP1/GMPS/UCKL1/AK2/AK9/AK1/AK3/NME7/AMPD2	2.76377918796838
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	36/1862	122/9376	1.48586923984434	PIK3R3/CREB5/PIK3CA/ELAVL1/HMGCR/RAB8A/ADIPOR2/PPP2R2D/CAB39/PRKAA1/PPP2R5A/SIRT1/AKT1/STK11/ACACA/LEPR/RAB10/CREB1/PPP2CA/ACACB/ADIPOR1/SREBF1/PPP2R5E/PPP2R2A/PPP2R1B/CPT1A/TSC1/PPP2R3C/MAP3K7/TSC2/TBC1D1/MLYCD/MTOR/CAMKK2/RHEB/RAB14	2.68889877857654
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	23/1862	70/9376	1.65450360595366	ACSL3/NFKB1/TNFRSF1A/ADIPOR2/MAPK8/PRKAA1/TNFRSF1B/AKT1/IKBKB/STK11/LEPR/RELA/ACACB/ADIPOR1/JAK2/CPT1A/ACSL4/NFKBIA/ACSL5/CHUK/NFKBIE/MTOR/CAMKK2	2.73602096376114
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	40/1862	139/9376	1.44904913877706	HSPA1A/FKBP4/SOS2/PIK3R3/GNAI3/PLCB4/HSP90B1/HSPA8/ATF2/SOS1/HBEGF/HSP90AB1/HSPA1B/PRKACB/NRAS/ESR2/CREB5/PIK3CA/ITPR2/ADCY4/RAF1/PLCB1/HSP90AA1/NOS3/SHC1/AKT1/NCOA3/ATF6B/CREB1/KRAS/ITPR1/NCOA1/EBAG9/NCOA2/GNAQ/SP1/ITPR3/HSPA6/GNAS/CALML4	2.65506817623442
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	79/1862	308/9376	1.29155913903497	PSMA2/PLCB4/PSMD12/SDHD/MT-ND6/CREB5/BBC3/NDUFA7/PLCB1/NDUFB5/POLR2K/CASP3/EP300/MAPK8/POLR2C/NDUFC2/CLTC/ACTR10/NDUFB3/HDAC1/SOD2/PSMA3/SIN3A/CASP8/ERN1/VDAC3/TBPL1/PSMA6/HIP1/PSMA1/IFT57/CYCS/PSMD11/TFAM/CREB1/PSMA5/VDAC1/HTT/DCTN4/VDAC2/PIK3C3/NDUFS4/PSMB5/ITPR1/PSMB2/PSMC6/SDHA/BECN1/PSMC2/SDHB/PSMC4/DCTN6/UQCRC2/ATP5F1C/POLR2H/TBP/NDUFC1/GNAQ/UQCRFS1/SP1/DCTN5/ATP5MC3/ADRM1/NDUFB6/POLR2B/ATG2B/TUBB2A/NDUFA9/NDUFB8/POLR2A/POLR2J/PSMD9/PIK3R4/MTOR/MT-ND4L/NRBF2/COX7B/NDUFAB1/NDUFV2	2.5899187679958
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	26/1862	82/9376	1.59660475229887	HSPA5/HSPA1A/CALR/B2M/NFYB/HSPA8/HLA-DQB1/TAP1/HSP90AB1/HSPA4/HSPA1B/PDIA3/HLA-B/TAP2/HLA-F/NFYA/HLA-A/HSP90AA1/CANX/HLA-C/CIITA/CREB1/RFX5/HLA-DRB1/LGMN/HSPA6	2.70104725163585
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	28/1862	90/9376	1.56658312447786	PIK3R3/ATF2/NFKB1/PRKACB/NRAS/CREB5/PIK3CA/ADCY4/ADIPOR2/EIF4E/ATG5/PRKAA1/SIRT1/SOD2/AKT1/ATF6B/STK11/CREB1/RELA/KL/ADIPOR1/KRAS/EHMT1/TSC1/TSC2/MTOR/CAMKK2/RHEB	2.68850241699491
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	49/1862	178/9376	1.38616203429923	CACYBP/SIAH1/TLE1/NFATC1/PLCB4/CUL1/CAMK2D/PRKACB/RYK/PLCB1/SOX17/EP300/FOSL1/LRP6/MAPK8/CSNK2A1/CCAR2/CCDC88C/RSPO3/SIRT1/CSNK1A1/FZD6/RUVBL1/PPP3R1/CBY1/DVL3/APC/CTNNB1/PSEN1/GSK3B/LZTS2/PPP3CA/CTBP2/CSNK2A2/FZD4/NFATC3/NLK/SMAD4/VANGL1/WNT2B/CSNK1E/WNT5B/TBL1XR1/MAP3K7/LEF1/PPP3CB/PPARD/SKP1/SENP2	2.58924265756534
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	21/1862	63/9376	1.67848191908342	MECOM/NSD1/AASS/DOT1L/DLST/PLOD2/SETD2/PHYKPL/NSD3/ALDH9A1/SETDB1/ECHS1/DLD/EHMT1/PLOD3/KMT5A/SETD7/ALDH3A2/KMT5B/SETD1B/EZH1	2.68969869965475
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	32/1862	107/9376	1.50592770310288	SIK1/PLCB4/CAMK2D/ATF2/PRKACB/CREB5/ITPR2/PLCB1/EP300/PRKAA1/PPP4R3A/SIRT1/PPP3R1/PRMT1/AKT1/PPP3CA/ACACA/PDHB/CREB1/ACACB/ITPR1/PPP4R3B/SIK2/CPT1A/PGAM1/GNAQ/PPP4C/ITPR3/GNAS/PPP3CB/PDHA1/CALML4	2.62001507197244
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/1862	67/9376	1.65342995014188	PPP1CB/PLCB4/CAMK2D/PRKACB/NRAS/ITPR2/RAF1/PLCB1/EP300/RPS6KA3/PPP3R1/PPP3CA/BRAF/KRAS/ITPR1/RAP1A/GNAQ/ITPR3/PPP3CB/PPP1CC/RAPGEF3/CALML4	2.67192832521501
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	47/1862	170/9376	1.3921526505339	F11R/ARHGEF2/ARPC5L/HSPA4/PRKACB/MPDZ/RAB8A/NEDD4/WHAMM/MYL12B/PPP2R2D/CLDN14/MAPK8/PRKAA1/RAP2C/YBX3/HCLS1/ARPC1B/ARHGAP17/ARPC1A/PRKCI/STK11/AFDN/PPP2CA/ACTR2/ACTR3/NEDD4L/JAM2/CGNL1/RAP1A/CLDN15/CLDN5/MSN/MICALL2/TIAM1/RAB13/LLGL1/PPP2R2A/PPP2R1B/CDC42/JAM3/MYH9/MYL12A/TJP1/OCLN/PRKCE/AMOTL2	2.56852626642599
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1862	87/9376	1.56272454535353	SOS2/PIK3R3/SOS1/NRAS/BBC3/PIK3CA/POLK/RAF1/CASP3/SMAD2/MAPK8/RALB/PMAIP1/AKT1/APC/CTNNB1/GSK3B/BRAF/CYCS/KRAS/SMAD4/MSH6/BAK1/LEF1/MSH3/GADD45A/MTOR	2.62488864996944
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/1862	83/9376	1.57736855046394	MLKL/IRF7/TBK1/CASP1/NFKB1/CASP7/CGAS/POLR2K/CASP3/ADAR/FADD/CASP8/IKBKB/POLR1D/RELA/SAMHD1/POLR3K/IL33/IFI16/POLR2H/NFKBIA/ZCCHC3/CHUK/RIPK1/G3BP1/POLR3F	2.62998991255282
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	34/1862	116/9376	1.47590651505611	F11R/PIK3R3/GNAI3/PECAM1/CDH5/PIK3CA/ESAM/MYL12B/CLDN14/PTK2/BCAR1/CTNND1/CTNNB1/MAPK12/AFDN/PLCG1/RAPGEF4/VCAM1/VCL/JAM2/RAP1A/CLDN15/CLDN5/MAPK14/MSN/CDC42/JAM3/MAPK11/MYL12A/CTNNA1/RAPGEF3/ARHGAP5/OCLN/PXN	2.5673497265773
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/1862	56/9376	1.70845481049563	ALG13/MGAT4A/ALG6/DDOST/MGAT2/B4GALT1/STT3B/ALG5/RPN1/DPM2/MOGS/DPM1/DAD1/FUT8/OSTC/ALG2/ALG8/DOLPP1/MAN1A2	2.64690340142535
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1862	76/9376	1.59014076544745	SOS2/PIK3R3/CAMK2D/SOS1/NRAS/PIK3CA/PDGFB/POLK/RB1/RAF1/MDM2/SHC1/AKT1/BRAF/PLCG1/KRAS/BAK1/PTEN/E2F3/CAMK1D/GADD45A/CALML4/CAMK1/MTOR	2.57134777318531
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	49/1862	181/9376	1.36318697295725	RIPK2/TRAF6/HSPD1/CAMK2D/NFYB/LAMP2/HLA-DQB1/IRAK2/NFKB1/CEBPG/ARHGEF12/STAT1/PLK3/TNFRSF1A/CASP10/RAF1/IFNGR1/ATP6V0A1/CASP3/FADD/EP300/MAPK8/NFYA/MYD88/RAB7A/PPP3R1/AKT1/BCL10/CASP8/CIITA/LAMP1/PPP3CA/MAPK12/CYCS/HSPA9/CREB1/RELA/MALT1/IFNGR2/RFX5/PIK3C3/MAPK14/HLA-DRB1/IRAK4/JAK2/RAB5A/MAPK11/PPP3CB/CALML4	2.45602941763572
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	37/1862	130/9376	1.43316533090969	SOS2/PIK3R3/GNAI3/PLCB4/ATF2/GNB4/SOS1/NFKB1/PRKACB/NRAS/CREB5/PIK3CA/ADCY4/RAF1/PLCB1/SMAD2/MAPK8/NOS3/ARRB1/SHC1/COL4A1/AKT1/ATF6B/RXFP1/GNG5/MAPK12/CREB1/RELA/KRAS/VEGFC/MAPK14/EDN1/COL4A2/NFKBIA/MAPK11/GNAS/GNG12	2.47564462573095
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/1862	57/9376	1.67848191908342	HSD17B4/ELOVL5/ACSL3/ACADM/SCP2/HACD2/ACADVL/ACACA/HADHB/PPT2/ECHS1/ACOX1/ACAA2/CPT1A/ACSL4/HSD17B12/ACSL5/HACD3/OXSM	2.55759003843123
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	28/1862	93/9376	1.51604818497858	SOS2/PLCB4/CAMK2D/SOS1/MAP2K3/HBEGF/PRKACB/NRAS/PLA2G4A/ELK1/ITPR2/ADCY4/RAF1/PLCB1/MAPK8/MAPK12/PLA2G4C/MAP2K6/KRAS/MAPK7/ITPR1/MAPK14/CDC42/GNAQ/ITPR3/MAPK11/GNAS/CALML4	2.48958773134772
Organismal Systems	Endocrine system	hsa04924	Renin secretion	22/1862	69/9376	1.60550444434067	GNAI3/PLCB4/PRKACB/ITPR2/PLCB1/KCNJ2/PPP3R1/PPP3CA/CREB1/PDE3A/ITPR1/EDN1/GUCY1B1/GUCY1A1/GNAQ/ITPR3/GNAS/PPP3CB/ORAI1/CALML4/ADRB1/ADRB2	2.51290982726391
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	24/1862	77/9376	1.56948958667541	PIK3R3/NFKB1/PIK3CA/STAT1/POLK/RB1/RAF1/SMAD2/MAPK8/RALB/AKT1/IKBKB/BRAF/RELA/KRAS/SMAD4/BAK1/BRCA2/CDC42/E2F3/RALBP1/CHUK/GADD45A/MTOR	2.49777265728174
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	41/1862	148/9376	1.3949545678869	SOS2/PIK3R3/DLL4/SOS1/NRAS/ESR2/PIK3CA/POLK/RB1/RAF1/FGF18/DLL1/LRP6/HEY1/SHC1/CSNK1A1/FZD6/AKT1/DVL3/APC/NCOA3/CTNNB1/GSK3B/BRAF/FZD4/KRAS/NCOA1/BAK1/WNT2B/NOTCH4/BRCA2/HES1/WNT5B/PTEN/SP1/E2F3/LEF1/NOTCH1/JAG1/GADD45A/MTOR	2.41081612149634
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	61/1862	235/9376	1.30707315400964	ACSL3/SOS2/ATF2/SDHD/SOS1/MAP2K3/MT-ND6/PRKACB/NRAS/KDM3A/CREB5/NDUFA7/COA5/ADCY4/SMARCE1/ZNF516/NDUFB5/KDM1A/PRKAA1/NDUFC2/RPS6KA3/COX14/NDUFB3/MAPK12/COA1/CREB1/COX19/KRAS/COA3/NDUFS4/MAPK14/COX17/SDHA/SDHB/UQCRC2/COX10/ATP5F1C/NDUFC1/CPT1A/ACSL4/TSC1/UQCRFS1/ATP5MC3/ACSL5/TSC2/MAPK11/SMARCA2/NDUFB6/ARID1B/GNAS/NDUFAF1/NDUFA9/NDUFB8/SIRT6/SLC25A29/MTOR/MT-ND4L/COX7B/NDUFAB1/RHEB/NDUFV2	2.37311512641508
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	54/1862	205/9376	1.32641010190983	PPP1CB/PIK3R3/PLCB4/CAMK2D/SDHD/NFKB1/MT-ND6/ATP2A2/MPC2/PIK3CA/NDUFA7/PLCB1/NDUFB5/SMAD2/MAPK8/NDUFC2/NOS3/TBC1D4/NDUFB3/AKT1/VDAC3/GSK3B/MAPK12/PDHB/RELA/PDK3/VDAC1/VDAC2/NDUFS4/MAPK14/SDHA/SDHB/PDK4/UQCRC2/ATP5F1C/ATP2A3/NDUFC1/UQCRFS1/PTEN/SP1/ATP5MC3/MAPK11/NDUFB6/MPC1/NDUFA9/PPP1CC/NDUFB8/PDHA1/GSR/MTOR/MT-ND4L/COX7B/NDUFAB1/NDUFV2	2.3521881407863
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	37/1862	133/9376	1.40083829337038	PPP1CB/GNAI3/PLCB4/CAMK2D/ATF2/GNB4/PRKACB/CREB5/ITPR2/PLCB1/PPP2R2D/MAPK8/ARRB1/PPP2R5A/AKT1/ATF6B/GNG5/GSK3B/PPP3CA/MAPK12/CREB1/PPP2CA/COMT/ITPR1/PPP2R5E/MAPK14/PPP2R2A/PPP2R1B/GNAQ/PPP2R3C/ITPR3/MAPK11/GNAS/PPP3CB/PPP1CC/CALML4/GNG12	2.31754635476803
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	25/1862	83/9376	1.51670052929225	HSD17B4/FAR1/ACSL3/AGPS/SCP2/SOD2/PEX6/CROT/ABCD4/MPV17L2/IDH1/DDO/ABCD3/ACOX1/ACSL4/ACSL5/GSTK1/PEX26/PEX1/PEX14/PEX5/MLYCD/PEX19/GNPAT/PEX13	2.35363907292383
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	19/1862	59/9376	1.6215842269111	SOS2/PIK3R3/SOS1/NRAS/ELK1/PIK3CA/POLK/RAF1/AKT1/APC/CTNNB1/GSK3B/BRAF/KRAS/BAK1/PTEN/LEF1/CTNNA1/GADD45A	2.38411842829071
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	23/1862	75/9376	1.54420336555675	SIAH1/BBC3/CASP3/MDM4/MDM2/PMAIP1/SERPINE1/EI24/CASP8/CCNG1/ATR/RCHY1/CYCS/ZMAT3/TNFRSF10A/CDK2/TNFRSF10B/PTEN/TSC2/PPM1D/ATM/GADD45A/SHISA5	2.35541216626568
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/1862	63/9376	1.59855420865088	GTF2H2/POLR2K/GTF2H1/POLR2C/RAD23B/POLR2M/MNAT1/RPA1/CUL4B/CCNH/ERCC4/GTF2H5/POLR2H/POLE4/POLR2B/ERCC3/POLR2A/POLR2J/POLE3/GTF2H3	2.37284212209522
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	45/1862	168/9376	1.34878011354918	PPID/MLKL/TNFSF10/CYLD/CAMK2D/CHMP5/CASP1/HSP90AB1/BIRC2/TRPM7/PLA2G4A/GLUD1/STAT1/TNFRSF1A/SPATA2/IFNGR1/CHMP7/STAT2/TICAM1/FADD/MAPK8/DNM1L/TLR3/CHMP1B/HSP90AA1/VPS4B/EIF2AK2/BIRC3/CASP8/VDAC3/STAT5B/IFNAR1/CHMP4B/PLA2G4C/IFNGR2/VDAC1/VDAC2/IL33/TNFRSF10A/JAK2/TNFRSF10B/RIPK1/RBCK1/PGAM5/AIFM1	2.27071998063728
Genetic Information Processing	Transcription	hsa03040	Spliceosome	62/1862	243/9376	1.28476393806385	HSPA1A/TRA2A/DDX39B/SRSF7/HSPA8/SRSF10/HSPA1B/HNRNPU/SF3B3/SRSF5/WBP11/PRPF3/SRSF1/THOC1/CRNKL1/SF3B1/BCAS2/THOC7/SRSF2/HNRNPA3/DDX5/LSM6/DHX15/SRSF9/PRPF8/SNRPA1/RBMXL1/USP39/PHF5A/ACIN1/HNRNPC/ZMAT2/SRSF3/HNRNPK/LSM8/SNW1/RBM22/SRSF6/PRPF18/CDC5L/EFTUD2/BUD31/PPIL1/RBM17/SNRNP40/PRPF31/PLRG1/CWC25/CHERP/AQR/MAGOH/HSPA6/CDC40/SF1/SMNDC1/CCDC12/SF3A3/SF3B6/TRA2B/U2AF1L4/SF3B4/LSM5	2.23883083326114
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/1862	109/9376	1.432099252062	TRAF6/PIK3R3/IRF7/TBK1/MAP2K3/NFKB1/PIK3CA/STAT1/STAT2/CD40/TICAM1/FADD/MAPK8/TLR3/MYD88/LY96/AKT1/CASP8/IKBKB/MAPK12/IFNAR1/RELA/MAP2K6/MAPK14/IRAK4/NFKBIA/MAP3K7/MAPK11/CHUK/RIPK1/MAP3K8	2.25874426658772
Organismal Systems	Immune system	hsa04611	Platelet activation	35/1862	126/9376	1.39873493256952	PPP1CB/PIK3R3/GNAI3/PLCB4/SNAP23/PRKACB/ARHGEF12/PLA2G4A/PIK3CA/ITPR2/ADCY4/MYLK/STIM1/PLCB1/MYL12B/NOS3/AKT1/PRKCI/GNA13/MAPK12/PLA2G4C/ITPR1/RAP1A/MAPK14/GUCY1B1/GUCY1A1/GNAQ/ITPR3/ITGA2/MAPK11/MYL12A/GNAS/PPP1CC/ORAI1/ITGA2B	2.24304802695448
Organismal Systems	Nervous system	hsa04730	Long-term depression	19/1862	60/9376	1.59455782312925	GNAI3/PLCB4/NRAS/PLA2G4A/ITPR2/RAF1/PLCB1/GNA13/BRAF/PLA2G4C/PPP2CA/KRAS/ITPR1/GUCY1B1/PPP2R1B/GUCY1A1/GNAQ/ITPR3/GNAS	2.29982539023139
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1862	33/9376	1.83107118445464	STX6/SEC22B/SNAP23/VAMP4/VTI1A/STX18/BET1/STX17/STX5/GOSR1/VAMP3/STX4	2.38062999398135
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	42/1862	157/9376	1.34706192232173	PPP1CB/SAV1/ID1/BIRC2/BBC3/TP53BP2/SMAD7/RASSF1/PPP2R2D/SMAD2/SMAD1/BIRC3/FZD6/SERPINE1/PRKCI/DVL3/APC/CTNNB1/GSK3B/YWHAH/MOB1B/YWHAQ/FZD4/PPP2CA/TEAD2/YWHAG/MOB1A/WWTR1/SMAD4/ID2/WNT2B/CSNK1E/STK3/LLGL1/PPP2R2A/PPP2R1B/WNT5B/CSNK1D/LEF1/CTNNA1/LATS1/PPP1CC	2.18300518794305
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	21/1862	70/9376	1.51063372717508	SOS2/PIK3R3/HIF1A/CUL2/VHL/SOS1/NRAS/PIK3CA/PDGFB/RAF1/EP300/ETS1/AKT1/PRCC/FH/BRAF/KRAS/RAP1A/CDC42/PAK4/EPAS1	2.13460181066355
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1862	20/9376	2.01417830290011	LBR/SC5D/LIPA/SQLE/MSMO1/DHCR7/HSD17B7/FDFT1	2.26008143321471
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1862	75/9376	1.47706408879341	PIK3R3/TOP2B/BIRC2/BBC3/PIK3CA/CASP3/FADD/MDM2/BIRC3/PMAIP1/AKT1/CASP8/MGST2/CYCS/REV3L/MSH6/BAK1/GSTO2/GSTO1/ATM/ATP7A/MSH3	2.0648210392504
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/1862	47/9376	1.60705715656923	GLO1/ACYP1/FH/ACACA/PDHB/ADH5/ACACB/ME2/ALDH9A1/DLD/MDH1/ALDH3A2/PDHA1/ME1/ACSS2	2.07682951392534
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	59/1862	238/9376	1.24828277175532	RALGAPA2/PLA1A/SOS2/PIK3R3/RAPGEF5/TBK1/GNB4/SOS1/NFKB1/PDGFD/PRKACB/RASGRF1/NRAS/PLA2G4A/TEK/ELK1/PIK3CA/PDGFB/RALGAPA1/RAF1/SHOC2/RASSF1/RGL1/CSF1/FGF18/MAPK8/RALB/SHC1/RGL2/ETS1/NF1/AKT1/KITLG/EPHA2/GNG5/IKBKB/AFDN/RALGAPB/RELA/PLCG1/PLA2G4C/KRAS/VEGFC/RAP1A/ARF6/TIAM1/CDC42/RASA4/PAK4/RAB5A/KDR/RALBP1/CHUK/RASA1/RASA4B/CALML4/BRAP/RASGRF2/GNG12	1.93129834309592
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	39/1862	149/9376	1.31800258075678	SOS2/PIK3R3/PLCB4/SOS1/PDGFD/NRAS/PLA2G4A/PIK3CA/PDGFB/LPAR6/ADCY4/RAF1/PLCB1/RALB/SHC1/CYTH2/AKT1/KITLG/AGPAT5/GNA13/FCER1A/DGKE/PLCG1/PLA2G4C/RAPGEF4/DGKZ/KRAS/PIP5K1A/AGPAT1/ARF6/CYTH1/TSC1/TSC2/GNAS/ARF1/RAPGEF3/MTOR/RHEB/AGPAT4	1.94775083671063
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	30/1862	110/9376	1.37330338834098	ID3/ID1/CUL1/SKIL/ZFYVE16/SMAD9/SMAD7/SMAD6/EP300/SMAD2/SMAD1/SMURF2/TGIF2/HDAC1/LEMD3/ZFYVE9/SIN3A/PPP2CA/ACVR1B/SMURF1/SMAD5/SMAD4/ID2/SKI/NBL1/PPP2R1B/SP1/TGIF1/ACVR1/SKP1	1.96043301487741
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	34/1862	128/9376	1.3375402792696	ENPP4/PDE4B/NUDT9/CANT1/NTPCR/ADCY4/PGM2/HPRT1/GART/GMPR/GMPR2/AK6/NT5E/PRPS1/DCK/PNP/PDE3A/DGUOK/ENTPD4/NT5C2/PDE10A/GMPS/PDE6D/GUCY1B1/AK2/GUCY1A1/AK9/AK1/NPR2/AK3/NME7/PPAT/PAPSS2/AMPD2	1.91402039365828
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	37/1862	142/9376	1.31205276773422	TRAF6/PIK3R3/NFATC1/CYLD/NFKB1/ATP2A2/PIK3CA/ITPR2/STAT1/TNFRSF1A/IFNGR1/STAT2/CSF1/FOSL1/MAPK8/PPP3R1/AKT1/IKBKB/PPP3CA/MAPK12/IFNAR1/CREB1/RELA/MAP2K6/IFNGR2/RELB/FOSB/ITPR1/MAPK14/JUND/ATP2A3/ITPR3/NFKBIA/MAP3K7/MAPK11/CHUK/PPP3CB	1.86516456986687
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	36/1862	138/9376	1.31359454536964	PPP1CB/CUL1/CAMK2D/PRKACB/ITPR2/ADCY4/CDC23/CDC26/RPS6KA3/PPP2R5A/SPDYA/PPP3R1/CPEB2/YWHAH/PPP3CA/MAPK12/CDC16/YWHAQ/PPP2CA/ANAPC7/YWHAG/ITPR1/PPP2R5E/MAPK14/CDK2/CDC27/PPP2R1B/ANAPC10/ITPR3/MAPK11/ANAPC5/PPP3CB/PPP1CC/SLK/CALML4/SKP1	1.84739151847478
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	36/1862	138/9376	1.31359454536964	PPP1CB/SOS2/PIK3R3/SOCS4/SOS1/PRKACB/NRAS/ELK1/PIK3CA/RAF1/EIF4E/MAPK8/PRKAA1/SHC1/MKNK2/AKT1/PRKCI/PRKAR1A/IKBKB/GSK3B/BRAF/ACACA/HK1/ACACB/KRAS/SREBF1/SOCS2/EXOC7/TSC1/TSC2/PPP1R3B/PPP1R3D/PPP1CC/CALML4/MTOR/RHEB	1.84739151847478
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	27/1862	99/9376	1.37330338834098	SOS2/PIK3R3/HIF1A/SOS1/PDGFD/NRAS/PLA2G4A/PIK3CA/PDGFB/RAF1/MAPK8/SLC44A4/AKT1/GPCPD1/CHKA/DGKE/PLCG1/PLA2G4C/LYPLA1/DGKZ/KRAS/PIP5K1A/TSC1/SP1/TSC2/MTOR/RHEB	1.85872710469097
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1862	29/9376	1.73636060594837	SAV1/FAT4/RASSF1/MOB1B/TEAD2/MOB1A/WWTR1/CSNK1E/STK3/LATS1	1.97693916464678
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1862	78/9376	1.42025393153213	PIK3R3/ARPC5L/ELMO1/PIK3CA/DOCK1/CLTC/PTK2/BCAR1/SHC1/HCLS1/ARPC1B/ARPC1A/CD2AP/CTNNB1/WASL/ACTR2/ACTR3/VCL/ITGA5/CDC42/CTNNA1/PXN	1.85525750284524
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/1862	170/9376	1.27367157389271	SOS2/PIK3R3/PHF10/SOS1/NRAS/ELK1/PIK3CA/NQO1/POLK/RB1/RAF1/SMARCE1/ARID2/SMAD2/LRP6/SHC1/CSNK1A1/FZD6/AKT1/DVL3/APC/CTNNB1/MGST2/GSK3B/BRAF/FZD4/PLCG1/KRAS/SMAD4/BRD7/BAK1/WNT2B/WNT5B/PTEN/GSTO2/GSTO1/TXNRD1/E2F3/LEF1/SMARCA2/ARID1B/GADD45A/MTOR	1.7924974495533
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	29/1862	109/9376	1.33970575192897	PPP1CB/PIK3R3/NFKB1/OGT/CREB5/PIK3CA/TNFRSF1A/MAPK8/PRKAA1/RPS6KA3/NOS3/TBC1D4/AKT1/IKBKB/GSK3B/CREB1/RELA/ACACB/NR1H2/SREBF1/CPT1A/PTEN/NFKBIA/PPP1R3B/PPP1R3D/PPP1CC/SLC27A4/PRKCE/MTOR	1.77576891381966
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	36/1862	140/9376	1.29482890900721	KLF2/GNAI3/PLCB4/GNB4/PRKACB/NRAS/SLC8A1/ITPR2/ADCY4/RAF1/MYLK/PLCB1/SMAD2/PRKAA1/NOS3/MAP1LC3B/AKT1/SERPINE1/MEF2D/GNG5/GNA13/TFAM/KRAS/PIK3C3/SMAD4/ITPR1/BECN1/GNAQ/ITPR3/JAG1/SLC9A1/PRKCE/CALML4/PIK3R4/MTOR/GNG12	1.74957273549781
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1862	30/9376	1.67848191908342	PIGK/PIGF/PIGA/PGAP2/DPM2/PIGG/PIGP/PIGN/PIGO/PIGH	1.85278872323866
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	29/1862	110/9376	1.32752660872962	PIK3R3/GNAI3/HSP90AB1/PRKACB/PIK3CA/ADCY4/RAF1/CDC23/MAPK8/CDC26/CDC25B/RPS6KA3/HSP90AA1/SPDYA/AKT1/CPEB2/MAPK12/BRAF/CDC16/ANAPC7/KRAS/STK10/MAPK14/FZR1/CDK2/CDC27/ANAPC10/MAPK11/ANAPC5	1.72003254472974
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/1862	34/9376	1.62911480381626	POLR2K/POLR2C/POLR2M/POLR1D/POLR3K/CRCP/POLR2H/POLR2B/POLR2A/POLR2J/POLR3F	1.82931844325581
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/1862	15/9376	2.01417830290011	NTPCR/ALPL/AK2/AK1/ACP1/NFS1	1.95676514191527
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/1862	59/9376	1.45089115039415	CMPK2/CANT1/NT5C3A/DTYMK/NT5E/DUT/DCK/CDA/CDADC1/CMPK1/ENTPD4/NT5C2/DPYD/DCTPP1/UCKL1/AK9/NME7	1.72941631120511
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/1862	89/9376	1.35787301319108	SOS2/GNAI3/PLCB4/SOS1/PDGFD/PRKACB/NRAS/ITPR2/PDGFB/ADCY4/RAF1/PLCB1/KRAS/MAPK7/ITPR1/GUCY1B1/GUCY1A1/GNAQ/ITPR3/CSNK1D/GNAS/TUBB2A/TJP1/ADRB1	1.68859738222012
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1862	68/9376	1.40696278511405	SOS2/PIK3R3/SOS1/NFKB1/NRAS/PIK3CA/RAF1/RUNX1T1/AKT1/IKBKB/STAT5B/BRAF/RELA/KRAS/DUSP6/LEF1/CHUK/PPARD/MTOR	1.67656674268835
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	30/1862	116/9376	1.30227045446128	SDHD/GLUD1/DLST/HIBCH/SUCLA2/FH/GOT2/PRPS1/PDHB/ADH5/HK1/PCCA/ME2/IDH1/ACO2/IDH3A/SDHA/SDHB/ECHS1/ACOX1/DLD/MDH1/PGAM1/ADPGK/PGP/RPE/ALDH6A1/PDHA1/ME1/ACSS2	1.63064371691161
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/1862	23/9376	1.75145939382618	HMGCS1/IDI1/HMGCR/NUS1/GGPS1/FNTA/FDPS/ICMT	1.79611380066363
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	13/1862	43/9376	1.52234406614543	ACSL3/ACADM/ACADVL/ADH5/HADHB/ALDH9A1/ECHS1/ACOX1/ACAA2/CPT1A/ACSL4/ALDH3A2/ACSL5	1.70891373957741
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/1862	31/9376	1.62433734104847	CNDP2/HIBCH/CSAD/ALDH9A1/DPYD/ECHS1/ACOX1/ALDH3A2/ALDH6A1/MLYCD	1.73320680568241
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	41/1862	166/9376	1.24369443401964	PPP1CB/GNAI3/NFATC1/PLCB4/ATF2/GTF2I/ATP2A2/CREB5/SLC8A1/ITPR2/ADCY4/RAF1/MYLK/PLCB1/NOS3/PPP3R1/AKT1/ATF6B/VDAC3/MEF2D/GNA13/PPP3CA/ATP1A1/CREB1/NFATC3/VDAC1/VDAC2/PDE3A/ITPR1/GUCY1B1/ATP2A3/GUCY1A1/GNAQ/ITPR3/NPR2/PPP3CB/PPP1CC/PRKCE/CALML4/ADRB1/ADRB2	1.57692021331789
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	26/1862	99/9376	1.32244029988391	PPP1CB/PIK3R3/PLCB4/CAMK2D/MAP2K3/PRKACB/PLA2G4A/PIK3CA/ITPR2/ADCY4/PLCB1/MAPK8/MAPK12/PLCG1/PLA2G4C/MAP2K6/ITPR1/MAPK14/GNAQ/ITPR3/MAPK11/GNAS/PPP1CC/HRH1/PRKCE/CALML4	1.60547303816988
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/1862	86/9376	1.34668898159019	SOS2/PIK3R3/CAMK2D/NCK1/SOS1/HBEGF/NRAS/ELK1/PIK3CA/RAF1/MAPK8/PTK2/SHC1/CDKN1B/AKT1/GSK3B/STAT5B/BRAF/PLCG1/KRAS/PAK4/NCK2/MTOR	1.60776025723019
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	36/1862	144/9376	1.25886143931257	ID3/ID1/KLF4/PIK3R3/SMARCAD1/SKIL/NRAS/PIK3CA/PCGF5/SMAD9/RAF1/SMAD2/SMAD1/FZD6/KAT6A/AKT1/DVL3/APC/CTNNB1/GSK3B/MAPK12/FZD4/ACVR1B/PCGF3/KRAS/SMAD5/SMAD4/SETDB1/ID2/MAPK14/WNT2B/JAK2/WNT5B/MAPK11/ACVR1/ISL1	1.558262397785
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/1862	104/9376	1.30727918697844	PLA1A/ETNK1/PLA2G4A/SAMD8/MBOAT7/AGPAT5/GPCPD1/CHKA/GPD1L/DGKE/PLA2G4C/LYPLA1/DGKZ/LPGAT1/PGS1/AGPAT1/CEPT1/GPD2/LPCAT3/PLPP5/CDS2/SELENOI/SGMS1/LYPLA2/GNPAT/AGPAT4/LCLAT1	1.56856667657916
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1862	48/9376	1.468671679198	HMGCS1/ACADM/HIBCH/PCCA/HIBADH/HADHB/ALDH9A1/ECHS1/DLD/ACAA2/DBT/ALDH3A2/HSD17B10/ALDH6A1	1.62044741367542
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/1862	227/9376	1.19785934313443	SOS2/PRKD3/PIK3R3/HIF1A/SDHD/SOS1/NFKB1/MT-ND6/NRAS/PIK3CA/NDUFA7/NQO1/RAF1/NDUFB5/MAPK8/NDUFC2/PTK2/NDUFB3/AHR/SOD2/AKT1/VDAC3/MGST2/IKBKB/MAPK12/BRAF/SLC26A2/RELA/KRAS/VDAC1/VDAC2/NDUFS4/MAPK14/SDHA/SDHB/UQCRC2/ATP5F1C/NDUFC1/UQCRFS1/PTEN/GSTO2/GSTO1/ATP5MC3/NFKBIA/MAPK11/NDUFB6/CHUK/NDUFA9/ACP1/NDUFB8/MT-ND4L/COX7B/NDUFAB1/NDUFV2	1.50218201796119
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1862	28/9376	1.61853613625901	ELOVL5/HACD2/HADHB/PPT2/ECHS1/ACAA2/HSD17B12/ACOT7/HACD3	1.631641046437
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/1862	75/9376	1.34278553526674	HSPA5/PLCB4/HSP90B1/PDIA4/ATF2/PRKACB/CREB5/ITPR2/ADCY4/PLCB1/CANX/ATF6B/ATP1A1/CREB1/ITPR1/GNAQ/ITPR3/TTF2/GNAS/GSR	1.48363878521985
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1862	62/9376	1.3806867398912	HSPA1A/PIK3R3/HSPA8/HSPA1B/PRKACB/NRAS/PIK3CA/ADCY4/ATG5/PRKAA1/SIRT1/HDAC1/SOD2/AKT1/KRAS/HSPA6/MTOR	1.49704673635609
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	21/1862	80/9376	1.3218045112782	SOS2/PIK3R3/SOS1/PDGFD/NRAS/PIK3CA/PDGFB/RAF1/EIF4E/SHC1/NF1/AKT1/GSK3B/BRAF/PLCG1/KRAS/JAK2/PTEN/KDR/GAS6/MTOR	1.43889447555653
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1862	17/9376	1.77721614961774	SEPHS2/TXNRD1/SEPHS1/PAPSS2/SCLY/SEPSECS	1.59658275605677
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	37/1862	154/9376	1.20981488972896	GCH1/CMPK2/RFK/PTS/NQO1/MTHFD2L/MOCS2/NADK/SPR/PANK2/CPOX/AK6/RDH11/IDO1/ALPL/ALAS1/GGCX/CMPK1/PNPO/MAT2B/NMNAT1/DLD/COX10/AK2/AK9/AK1/ALDH3A2/AK3/NADK2/COQ7/PANK3/NME7/LIPT1/OXSM/NFS1/GCLM/NMNAT3	1.30684472060336
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	37/1862	154/9376	1.20981488972896	PPP1CB/GNAI3/NFATC1/PLCB4/CAMK2D/PTGS2/PRKACB/NRAS/PLA2G4A/ELK1/ITPR2/ADCY4/RAF1/MYLK/PLCB1/PRKAA1/KCNJ2/NOS3/PPP3R1/PPP3CA/NFATC3/PLA2G4C/KRAS/MAPK7/ITPR1/GUCY1B1/GUCY1A1/GNAQ/ITPR3/NPR2/GNAS/PPP3CB/PPP1CC/CAMK1D/CALML4/CAMK1/CAMKK2	1.30684472060336
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/1862	38/9376	1.4576290349935	NADK/SIRT1/NT5E/NNT/PNP/NT5C2/NMNAT1/NADK2/SIRT6/SIRT2/NMNAT3	1.40707846340848
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1862	51/9376	1.38227922748047	PDIA4/PRKACB/ERO1A/ATP6V0A1/ATP6V1C1/ATP6V1E2/ATP6V1E1/PLCG1/ATP6V1A/ATP6V1B2/GNAS/ARF1/TJP1/ATP6V1D	1.3626403616439
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/1862	91/9376	1.27269508150282	SOS2/PIK3R3/NFATC1/SOS1/NFKB1/NRAS/PIK3CA/RAF1/PPP3R1/AKT1/BCL10/IKBKB/GSK3B/PPP3CA/RELA/NFATC3/MALT1/KRAS/NFKBIA/CHUK/PPP3CB/NFKBIE/CD22	1.30120860933014
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	37/1862	155/9376	1.20200963237587	GNAI3/PLCB4/CAMK2D/ATF2/PRKACB/CREB5/ITPR2/ADCY4/RB1/PLCB1/CDKN1B/FZD6/AHR/DVL3/APC/ATF6B/FH/CTNNB1/GSK3B/BRAF/NR4A1/CREB1/FZD4/ITPR1/RAP1A/WNT2B/CDK2/WNT5B/GNAQ/SP1/ITPR3/E2F3/LEF1/GNAS/ORAI1/WDR5/ASH2L	1.26237619850894
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1862	69/9376	1.31359454536964	SOS2/PIK3R3/SOS1/MAP2K3/NRAS/PLA2G4A/PIK3CA/RAF1/MAPK8/AKT1/MAPK12/FCER1A/PLCG1/PLA2G4C/MAP2K6/KRAS/MAPK14/MAPK11	1.30145174358515
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/1862	26/9376	1.54936792530778	LMBRD1/FOLH1/ABCC1/TCN2/ABCD4/SLC52A3/BTD/CUBN	1.39631707662732
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1862	18/9376	1.67848191908342	ACSL3/ACACA/ACACB/ACSL4/ACSL5/OXSM	1.43424350512454
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1862	18/9376	1.67848191908342	NEU1/MAN2B1/MANBA/GBA2/ENGASE/FUCA1	1.43424350512454
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1862	18/9376	1.67848191908342	LMBRD1/TCN2/MMADHC/ABCD4/ZNF143/CD320	1.43424350512454
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1862	56/9376	1.34878011354918	CUL1/CUL3/PRKACB/SPOP/MOSMO/ARRB1/SMURF2/CSNK1A1/CSNK1G3/GSK3B/SMURF1/CSNK1E/DHH/CSNK1D/EVC2	1.30309972524146
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	49/1862	212/9376	1.16385302879841	ID1/PRKD3/PIK3R3/GNAI3/PLCB4/RAPGEF5/MAP2K3/PDGFD/NRAS/TEK/PIK3CA/PDGFB/FARP2/ADCY4/RAF1/PLCB1/CSF1/FGF18/RALB/BCAR1/CTNND1/ARAP3/AKT1/SIPA1L2/PRKCI/KITLG/CTNNB1/EPHA2/MAPK12/BRAF/AFDN/PLCG1/MAP2K6/RAPGEF4/KRAS/SIPA1L1/VEGFC/RAP1A/MAPK14/TIAM1/CDC42/GNAQ/KDR/MAPK11/GNAS/MAGI3/RAPGEF3/CALML4/ITGA2B	1.20121222932948
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	28/1862	115/9376	1.22602157567833	PDE4B/GNAI3/PLCB4/ATF2/HBEGF/PRKACB/CREB5/ITPR2/ADCY4/RAF1/PLCB1/LRP6/ARHGEF11/ARRB1/ATF6B/MEF2D/GNA13/BRAF/CREB1/KL/ITPR1/JUND/GNAQ/SP1/ITPR3/PTHLH/GNAS/MMP24	1.21397503989052
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/1862	138/9376	1.2041283332555	SDHD/MT-ND6/NDUFA7/ATP6V0A1/NDUFB5/NDUFC2/NDUFB3/PPA1/ATP6V1C1/ATP6V1E2/CYCS/ATP6V1E1/NDUFS4/COX17/SDHA/SDHB/ATP6V1A/ATP6V1B2/UQCRC2/COX10/ATP5F1C/PPA2/NDUFC1/UQCRFS1/ATP5MC3/NDUFB6/NDUFA9/NDUFB8/MT-ND4L/COX7B/NDUFAB1/ATP6V1D/NDUFV2	1.20252395044724
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1862	48/9376	1.36376655925528	LAMP2/IST1/CHMP7/CLDN14/CHMP1B/VPS4B/TSG101/LAMP1/CHMP4B/CLDN15/PDCD6IP/CLDN5/OCLN	1.2577345854043
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	53/1862	232/9376	1.15033890144079	PPP1CB/SOS2/PIK3R3/ARPC5L/SOS1/PDGFD/ABI2/NRAS/ARHGEF12/PIK3CA/PDGFB/ITGAV/RAF1/MYLK/DOCK1/MYL12B/FGF18/PTK2/BCAR1/SPATA13/ARPC1B/ARPC1A/AKT1/APC/CFL2/GNA13/BRAF/ARHGEF7/WASL/ACTR2/KRAS/ACTR3/PIP5K1A/NCKAP1/VCL/MSN/SSH2/ITGA5/TIAM1/PIP4K2A/BAIAP2/CDC42/PAK4/ITGA2/PIKFYVE/MYH9/MYL12A/SLC9A1/SSH1/PPP1CC/PXN/ITGA2B/GNG12	1.15421612503377
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	47/1862	204/9376	1.16012720877825	PPP1CB/SOS2/HOXD10/PIK3R3/HIF1A/CAMK2D/SDC4/SOS1/HBEGF/PRKACB/NRAS/ARHGEF12/ELK1/PIK3CA/ITPR2/ITGAV/RAF1/CASP3/DDX5/SMAD2/PTK2/MDM2/FZD6/HCLS1/AKT1/CTNNB1/MAPK12/BRAF/FZD4/PLCG1/KRAS/ITPR1/MAPK14/MSN/WNT2B/ITGA5/TIAM1/CDC42/WNT5B/ITPR3/KDR/ITGA2/MAPK11/SLC9A1/PPP1CC/PXN/MTOR	1.15103379580291
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1862	44/9376	1.37330338834098	ALG13/MGAT4A/DDOST/MGAT2/B4GALT1/STT3B/RPN1/DAD1/FUT8/OSTC/ALG2/MAN1A2	1.23549441411175
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1862	27/9376	1.49198392807415	HSD17B4/ELOVL5/SCP2/HACD2/ACOX1/HSD17B12/ACOT7/HACD3	1.27435403675648
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1862	19/9376	1.59014076544745	DLST/PDHB/DLD/DBT/LIPT1/PDHA1	1.28175193736561
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1862	49/9376	1.33593458865823	C1GALT1C1/OGT/GXYLT1/B4GALT1/POFUT2/POGLUT1/GALNT7/GALNT18/PLOD3/MFNG/EOGT/POMT1/XXYLT1	1.17360419977363
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	8/1862	28/9376	1.43869878778579	ATP6V0A1/ATP6V1C1/ATP6V1E2/SLC12A7/ATP6V1E1/ATP6V1A/ATP6V1B2/ATP6V1D	1.15724677543125
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/1862	203/9376	1.14103696962321	PPP1CB/SOS2/PIK3R3/SOS1/PDGFD/BIRC2/RASGRF1/ELK1/PIK3CA/PDGFB/ITGAV/RAF1/MYLK/DOCK1/MYL12B/MAPK8/PTK2/BCAR1/SHC1/BIRC3/COL4A1/AKT1/LAMB1/CTNNB1/GSK3B/BRAF/PIP5K1A/VEGFC/VCL/RAP1A/PARVB/EMP2/ITGA5/CDC42/LAMA5/PAK4/COL4A2/PTEN/KDR/ITGA2/MYL12A/PPP1CC/ARHGAP5/PXN/ITGA2B/LAMA3	1.01126545362027
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1862	37/9376	1.36093128574332	NRAS/POLK/CCDC6/CTNNB1/BRAF/TFG/KRAS/BAK1/LEF1/GADD45A	1.09500243287512
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1862	110/9376	1.19019626989552	PIK3R3/HIF1A/CAMK2D/CUL2/VHL/NFKB1/TEK/PIK3CA/IFNGR1/EIF4E/EP300/NOS3/CDKN1B/MKNK2/AKT1/SERPINE1/PDHB/HK1/RELA/PLCG1/IFNGR2/EDN1/PDK1/PDHA1/MTOR/EPAS1	0.998831134286742
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	24/1862	101/9376	1.19654156607927	GNAI3/PLCB4/CAMK2D/PRKACB/NRAS/ADCY4/RAF1/PLCB1/EP300/FZD6/DVL3/KITLG/CTNNB1/GSK3B/CREB1/FZD4/KRAS/WNT2B/EDN1/WNT5B/GNAQ/LEF1/GNAS/CALML4	0.988548590410106
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/1862	78/9376	1.22658294086866	TRAF6/GNAI3/CASP1/NFKB1/CASP7/CASP3/TICAM1/MAPK8/MYD88/LY96/CFL2/MAPK12/RELA/C1R/MAPK14/IRAK4/ITGA5/MAPK11/CALML4	1.00027547518893
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/1862	78/9376	1.22658294086866	TRAF6/HLA-DQB1/NFKB1/PTGS2/ELK1/STAT1/IFNGR1/MYD88/MAPK12/RELA/IFNGR2/MAPK14/HLA-DRB1/IRAK4/JAK2/NFKBIA/MAP3K7/MARCKSL1/MAPK11	1.00027547518893
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1862	33/9376	1.37330338834098	DLST/GOT2/PDHB/IDH1/ACO2/IDH3A/DLD/DBT/PDHA1	1.06933949794274
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	16/1862	65/9376	1.23949434024622	PLCB4/ATF2/PRKACB/CREB5/ITPR2/ADCY4/PLCB1/ATF6B/NR4A1/CREB1/ITPR1/GNAQ/SP1/ITPR3/GNAS/ORAI1	0.964480942594752
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/1862	154/9376	1.14441949028415	PPP1CB/GNAI3/PLCB4/CAMK2D/ATF2/ATP2A2/PRKACB/CREB5/SLC8A1/ADCY4/PLCB1/PPP2R2D/PPP2R5A/AKT1/ATF6B/MAPK12/ATP1A1/CREB1/PPP2CA/RAPGEF4/PPP2R5E/MAPK14/ATP2A3/PPP2R2A/PPP2R1B/GNAQ/PPP2R3C/MAPK11/GNAS/SLC9A1/PPP1CC/RAPGEF3/CALML4/ADRB1/ADRB2	0.899525523064067
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/1862	98/9376	1.1817882899669	PRKD3/PLCB4/CAMK2D/ATF2/PRKACB/CREB5/ITPR2/ADCY4/PLCB1/ATF1/ATF6B/NR4A1/ATP1A1/CREB1/ITPR1/GNAQ/ITPR3/GNAS/CAMK1D/ORAI1/PRKCE/CALML4/CAMK1	0.90051642651245
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	34/1862	150/9376	1.14136770497673	SOS2/PIK3R3/SOS1/NRAS/PIK3CA/POLK/RB1/RAF1/FGF18/SMAD2/LRP6/SHC1/ABCB1/CSNK1A1/CDKN1B/FZD6/AKT1/DVL3/APC/CTNNB1/GSK3B/BRAF/FZD4/KRAS/SMAD4/BAK1/WNT2B/CDK2/WNT5B/E2F3/LEF1/CTNNA1/GADD45A/MTOR	0.868818366336885
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	43/1862	193/9376	1.12188687855835	SOS2/PIK3R3/GNAI3/CXCL2/PLCB4/GNB4/SOS1/NFKB1/PRKACB/NRAS/ELMO1/PIK3CA/STAT1/ADCY4/RAF1/PLCB1/CXCL3/STAT2/PTK2/ARRB1/BCAR1/SHC1/CXCL1/GRK5/AKT1/GNG5/IKBKB/GSK3B/STAT5B/BRAF/RELA/PLCG1/KRAS/RAP1A/JAK2/TIAM1/CDC42/GNAQ/NFKBIA/CX3CL1/CHUK/PXN/GNG12	0.851693237045301
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	24/1862	103/9376	1.1733077492622	PIK3R3/CXCL2/ARG2/PLCB4/NFKB1/PRKACB/PIK3CA/PLCB1/CXCL3/CASP3/PTK2/CXCL1/COL4A1/RAB7A/LAMB1/RELA/VCL/SERPINB9/LAMA5/GNAQ/COL4A2/RAB5A/GNAS/LAMA3	0.880372251933924
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1862	71/9376	1.20567011089091	PIK3R3/GLS/HIF1A/NRAS/PIK3CA/RAF1/AKT1/PDHB/HK1/KRAS/IDH1/PGAM1/PTEN/PDK1/PDHA1/SIRT6/MTOR	0.865928530602065
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1862	17/9376	1.48101345801478	LAMP2/PCDH1/LAMP1/MYH9/DAG1	0.988113529132608
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1862	44/9376	1.25886143931257	PRKACB/CREB5/DYNC1LI2/CREB1/NSF/DCTN4/DCTN6/RAB5A/DCTN5/GNAS/STX4	0.856734421085602
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/1862	31/9376	1.29946987283878	HSPA5/SRPRA/SPCS3/SRP54/SRP9/SRPRB/SRP68/IMMP1L	0.831350597786398
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	77/1862	362/9376	1.07107547875213	IL3RA/SOS2/PIK3R3/HSP90B1/MCL1/ATF2/GNB4/SOS1/NFKB1/PDGFD/HSP90AB1/NRAS/CREB5/TEK/PIK3CA/PDGFB/LPAR6/ITGAV/RAF1/EIF4E/CSF1/PPP2R2D/FGF18/PRKAA1/PTK2/HSP90AA1/NOS3/RBL2/MDM2/PPP2R5A/CDKN1B/COL4A1/DDIT4/AKT1/KITLG/LAMB1/ATF6B/PKN2/EPHA2/GNG5/IKBKB/GSK3B/YWHAH/NR4A1/STK11/YWHAQ/IFNAR1/CREB1/RELA/PPP2CA/YWHAG/KRAS/VEGFC/PHLPP1/PPP2R5E/CDK2/JAK2/ITGA5/PPP2R2A/PPP2R1B/LAMA5/OSMR/COL4A2/TSC1/PTEN/PPP2R3C/KDR/CDC37/ITGA2/TSC2/CHUK/IL4R/ITGA2B/MTOR/RHEB/LAMA3/GNG12	0.686523144870714
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/1862	73/9376	1.17263805305828	PIK3R3/PDGFD/NRAS/PIK3CA/PDGFB/POLK/RB1/RAF1/FGF18/MDM2/AKT1/BRAF/KRAS/BAK1/PTEN/E2F3/GADD45A	0.737099862712064
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/1862	73/9376	1.17263805305828	SOS2/PIK3R3/SOS1/NRAS/PIK3CA/POLK/RB1/RAF1/RASSF1/AKT1/STAT5B/BRAF/PLCG1/KRAS/BAK1/E2F3/GADD45A	0.737099862712064
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1862	50/9376	1.20850698174006	CNDP2/LAP3/ARG2/AMD1/NOS3/P4HA1/GOT2/ALDH18A1/ALDH9A1/ALDH3A2/ODC1/PYCR2	0.735864377128269
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/1862	155/9376	1.10454939191296	CALR/SEC22B/LAMP2/HLA-DQB1/TAP1/STX12/HLA-B/TAP2/ITGAV/HLA-F/ATP6V0A1/HLA-A/RAB7A/ATP6V1C1/CANX/HLA-C/ATP6V1E2/STX18/LAMP1/DYNC1LI2/ATP6V1E1/M6PR/VAMP3/C1R/PIK3C3/HLA-DRB1/ATP6V1A/ATP6V1B2/ITGA5/RAB5A/ITGA2/PIKFYVE/TUBB2A/ATP6V1D	0.653338468900014
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1862	69/9376	1.16763959588412	PPP1CB/CAMK2D/ATF2/PRKACB/CREB5/SIRT1/HDAC1/PPP3R1/ATF6B/PPP3CA/CREB1/FOSB/GNAS/PPP3CB/PPP1CC/CALML4	0.695722701745766
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1862	184/9376	1.09466212114136	PIK3R3/GNAI3/CAMK2D/NCK1/RGS3/SEMA7A/NRAS/ARHGEF12/PIK3CA/RYK/RAF1/MYL12B/SEMA3F/EFNB1/PTK2/EPHA4/EFNB2/PPP3R1/SRGAP2/SEMA3G/EPHA2/EPHB4/CFL2/FES/GSK3B/PPP3CA/PLCG1/NFATC3/KRAS/SSH2/LRIG2/CDC42/PAK4/WNT5B/NCK2/ROBO3/MYL12A/PPP3CB/SSH1/RASA1	0.645535330635697
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/1862	41/9376	1.22815750176836	NBN/UIMC1/RAD51C/RPA1/BRCA2/TOPBP1/MRE11/RAD51B/BABAM1/ATM	0.7288017406555
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/1862	65/9376	1.16202594398083	PIK3R3/PLCB4/NRAS/ESR2/PIK3CA/ITPR2/RAF1/PLCB1/ARRB1/AKT1/KRAS/ITPR1/GNAQ/ITPR3/KCNN2	0.652503666745432
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1862	37/9376	1.22483815716898	ASRGL1/GLS/GLUD1/FOLH1/RIMKLB/GOT2/DDO/ASNS/PPAT	0.682119668834374
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1862	37/9376	1.22483815716898	GMDS/PGM2/UXS1/CMAS/GALK2/HK1/GALT/PGM3/GNPNAT1	0.682119668834374
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/1862	70/9376	1.15095903022863	HLA-DQB1/EIF4G2/HLA-B/HLA-F/CD40/CASP3/SNTB1/HLA-A/CASP8/HLA-C/CYCS/HLA-DRB1/EIF4G3/CD55/DAG1/SGCB	0.631053927919588
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1862	10/9376	1.51063372717508	SQOR/BPNT1/PAPSS2	0.804215243807042
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1862	52/9376	1.16202594398083	STARD3NL/NPC1/SORT1/VDAC3/LIPA/STARD3/VAPA/VDAC1/VDAC2/MYLIP/LDLRAP1/VAPB	0.583210025427825
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	29/1862	134/9376	1.08976064895715	PPP1CB/PLCB4/CALCRL/PRKACB/ARHGEF12/PLA2G4A/ITPR2/ADCY4/RAF1/MYLK/PLCB1/RAMP3/ARHGEF11/GNA13/BRAF/PLA2G4C/ITPR1/EDN1/GUCY1B1/GUCY1A1/GNAQ/RAMP2/ITPR3/NPR2/MYH9/GNAS/PPP1CC/PRKCE/CALML4	0.520949087992393
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	42/1862	201/9376	1.05218269554483	DDIT3/LMO2/NFKB1/CCNT2/BIRC2/KDM6A/TSPAN7/POLK/DOT1L/CD40/SS18L1/DDX5/ELK4/HHEX/SMAD1/PTK2/KLF3/MDM2/BIRC3/CDKN1B/RUNX1T1/HDAC1/SIN3A/ATF1/PRCC/CDK9/EWSR1/AFF1/RELA/SS18/ID2/BAK1/MLLT3/LDB1/PBX3/SP1/FUT8/DUSP6/ETV6/JMJD1C/ATM/GADD45A	0.372272865872488
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1862	54/9376	1.11898794605562	AMD1/CISD1/APIP/GOT2/DNMT3A/MRI1/MAT2B/ADI1/MDH1/AHCYL1/GCLM/DNMT1	0.436500936353602
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	12/1862	54/9376	1.11898794605562	POLK/RAD51C/WDR48/RPA1/ATR/REV3L/PMS2/ERCC4/RMI1/BRCA2/HES1/FANCL	0.436500936353602
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1862	30/9376	1.1749373433584	NFKB1/ABCC1/GART/IKBKB/RELA/ABCC5/CHUK	0.477716395870401
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	35/1862	168/9376	1.04905119942714	STAM2/IL3RA/SOS2/PIK3R3/SOCS4/MCL1/IL27RA/SOS1/PIK3CA/TSLP/STAT1/PDGFB/RAF1/IFNGR1/STAT2/EP300/AKT1/STAT5B/PIAS1/LEPR/IFNAR1/IL15RA/IFNGR2/PIAS4/SOCS2/JAK2/SOCS5/OSMR/IL13RA1/IL15/IL4R/PIAS2/PIAS3/PTPN2/MTOR	0.319346012821697
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1862	21/9376	1.19891565648816	PANK2/CSAD/DPYD/ALDH3A2/PANK3	0.454251740525616
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1862	36/9376	1.11898794605562	C1GALT1C1/ST6GALNAC3/ST3GAL2/GALNT7/GALNT18/GCNT4/ST6GALNAC1/ST6GALNAC4	0.35605792889097
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1862	41/9376	1.10534175159152	HBEGF/NRAS/RB1/RAF1/RASSF1/MDM2/BRAF/KRAS/E2F3	0.33649234116153
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	24/1862	115/9376	1.05087563629571	DUSP1/GNAI3/PLCB4/APP/GNB4/PTGS2/PRKACB/NRAS/PLA2G4A/ITPR2/RAF1/PLCB1/CASP3/GNG5/BRAF/PLA2G4C/KRAS/ITPR1/GNAQ/ITPR3/GNAS/RAPGEF3/KCNN2/GNG12	0.273256004061477
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1862	12/9376	1.25886143931257	NQO1/GGCX/COQ7	0.446649819958696
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1862	76/9376	1.06009384363164	GNAI3/PLCB4/CAMK2D/PRKACB/ITPR2/ADCY4/MYLK/PLCB1/KCNJ2/ATP1A1/ITPR1/GNAQ/ITPR3/GNAS/SLC9A1/CALML4	0.261839513640769
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	44/1862	217/9376	1.02101204294475	KLF4/SOS2/PIK3R3/GNAI3/HSP90B1/DLL4/PTGES3/ATF2/SOS1/NFKB1/HSP90AB1/PRKACB/NRAS/ESR2/CREB5/KPNA1/PIK3CA/KPNA4/ADCY4/RB1/RAF1/FGF18/DLL1/RPS6KA3/HSP90AA1/ARRB1/AHR/AKT1/ATF6B/MGST2/STAT5B/CREB1/RELA/KRAS/KPNA3/JAK2/GSTO2/GSTO1/JAG1/GNAS/KPNA2/ADRB1/MTOR/ADRB2	0.155888471338472
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	27/1862	133/9376	1.02223334921622	TNFSF10/SOS2/PIK3R3/NFATC1/SOS1/NRAS/PIK3CA/HLA-B/RAF1/IFNGR1/CASP3/HLA-A/SHC1/PPP3R1/SH3BP2/HLA-C/PPP3CA/BRAF/IFNAR1/PLCG1/IFNGR2/KRAS/MICB/TNFRSF10A/TNFRSF10B/PPP3CB/MICA	0.128547641985703
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1862	38/9376	1.06009384363164	PGM2/UXS1/GALK2/GNPDA2/HK1/GALT/PGM3/GNPNAT1	0.184771390562472
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1862	23/9376	1.09466212114136	GLS/ARG2/GLUD1/NOS3/GOT2	0.226258322910022
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1862	23/9376	1.09466212114136	RPA1/PMS2/MSH6/MLH3/MSH3	0.226258322910022
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1862	149/9376	1.01384813904368	GNAI3/PLCB4/GNB4/MT-ND6/PTGS2/PRKACB/ITPR2/NDUFA7/ADCY4/PLCB1/NDUFB5/MAPK8/NDUFC2/NDUFB3/GNG5/MAPK12/NDUFS4/ITPR1/MAPK14/NDUFC1/GNAQ/ITPR3/MAPK11/NDUFB6/NDUFA9/NDUFB8/MT-ND4L/NDUFAB1/NDUFV2/GNG12	0.0848191997216493
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/1862	49/9376	1.02764199127556	GNAI3/ATF2/NFKB1/PRKACB/CREB5/ATF6B/CREB1/RELA/FOSB/GNAS	0.0965686718378171
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1862	44/9376	1.02997754125574	PARP4/POLG2/POLB/PARP2/TDG/MBD4/PARG/POLE4/POLE3	0.0992144350333006
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/1862	44/9376	1.02997754125574	HSPD1/HLA-DQB1/HLA-B/HLA-F/HLA-A/CPE/PTPRN2/HLA-C/HLA-DRB1	0.0992144350333006
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1862	24/9376	1.04905119942714	EXT1/XYLT2/EXT2/HS2ST1/GLCE	0.119768575556858
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1862	55/9376	1.00708915145005	CERS2/NEU1/SAMD8/GALC/SPTLC2/UGCG/SPTLC1/DEGS1/GBA2/SGMS1/SPTLC3	0.0262472753010228
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1862	14/9376	1.07902409083934	B4GALT1/ST3GAL2/FUT8	0.14729197605008
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	19/1862	97/9376	0.986324426677888	PER1/GNAI3/PLCB4/CAMK2D/GNB4/PRKACB/ADCY4/PLCB1/GNG5/CREB1/ITPR1/GUCY1B1/GUCY1A1/GNAQ/ITPR3/GNAS/PER3/CALML4/GNG12	-0.0673939177069589
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1862	98/9376	0.976259891711787	PIK3R3/ARPC5L/PLA2G4A/PIK3CA/RAF1/DOCK1/ARPC1B/ARPC1A/AKT1/CFL2/PLCG1/PLA2G4C/ACTR2/ACTR3/PIP5K1A/ARF6/CDC42/MARCKSL1/PRKCE	-0.117600300242733
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1862	15/9376	1.00708915145005	ST6GALNAC3/ST3GAL2/ST6GALNAC4	0.0136778753830129
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1862	31/9376	0.974602404629084	PCCA/ACO2/DLD/MDH1/PGP/ACSS2	-0.0705056101096183
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1862	47/9376	0.964234293941541	PIK3R3/SOCS4/PIK3CA/MAPK8/IKBKB/HK1/SOCS2/PRKCE/MTOR	-0.122359605063177
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1862	63/9376	0.959132525190527	POLK/FZD6/DVL3/APC/CTNNB1/GSK3B/FZD4/BAK1/WNT2B/WNT5B/LEF1/GADD45A	-0.162010498381013
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1862	115/9376	0.963302666604399	PIK3R3/GNAI3/PLCB4/CAMK2D/GNB4/PRKACB/NRAS/CREB5/PIK3CA/ITPR2/ADCY4/PLCB1/KCNJ2/AKT1/GNG5/CREB1/KRAS/ITPR1/JAK2/GNAQ/ITPR3/GNG12	-0.197103513853046
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1862	37/9376	0.952651900020321	PLCB4/PLCB1/MYD88/APOL1/IDO1/VCAM1/GNAQ	-0.14364585924711
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1862	21/9376	0.959132525190527	CHST12/CSGALNACT2/CHSY1/XYLT2	-0.0933265982720412
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1862	16/9376	0.944146079484425	A4GALT/ST3GAL2/NAGA	-0.111305240089499
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1862	59/9376	0.93881192084327	LAP3/TXNDC12/LANCL1/MGST2/IDH1/GSTO2/GSTO1/ODC1/GSTK1/GCLM/GSR	-0.234690040051696
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1862	59/9376	0.93881192084327	PIK3R3/GNAI3/PTGS2/PRKACB/PIK3CA/ADCY4/AKT1/ABHD5/GNAS/ADRB1/ADRB2	-0.234690040051696
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1862	28/9376	0.899186742366119	GCH1/PTS/MOCS2/SPR/ALPL	-0.265936037585986
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/1862	39/9376	0.903797956429535	HLA-DQB1/HLA-B/HLA-F/CD40/HLA-A/HLA-C/HLA-DRB1	-0.29967657940613
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1862	17/9376	0.888608074808871	HSD17B4/SCP2/CYP39A1	-0.228824924715721
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1862	45/9376	0.895190356844492	ABCG1/TAP1/TAP2/ABCC1/ABCB1/ABCC5/ABCD4/ABCD3	-0.350819144919334
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1862	23/9376	0.87572969691309	B3GALNT2/B4GALT1/POMGNT1/POMT1	-0.297026836341179
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1862	23/9376	0.87572969691309	GLS/GLUD1/ATP1A1/MDH1	-0.297026836341179
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/1862	67/9376	0.90187088189557	MINPP1/PGM2/PDHB/ADH5/HK1/ALDH9A1/DLD/PGAM1/ADPGK/ALDH3A2/PDHA1/ACSS2	-0.401257962134524
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1862	116/9376	0.911589318122893	GNAI3/GLS/PLCB4/GNB4/PRKACB/PLA2G4A/ITPR2/ADCY4/PLCB1/PPP3R1/GNG5/PPP3CA/PLA2G4C/SLC38A2/ITPR1/SHANK3/GNAQ/ITPR3/GNAS/PPP3CB/GNG12	-0.476944804836175
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1862	12/9376	0.839240959541711	CD46/NPC1	-0.277380040333962
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	29/1862	160/9376	0.912674543501611	F11R/SDC4/HLA-DQB1/PECAM1/CDH5/HLA-B/SELP/ITGAV/HLA-F/ESAM/SELL/CD40/CLDN14/HLA-A/HLA-C/MAG/VCAM1/CD58/PTPRM/JAM2/CLDN15/CLDN5/HLA-DRB1/GLG1/JAM3/NECTIN2/OCLN/ALCAM/CD22	-0.554586768786718
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1862	53/9376	0.855075694627404	PLCB4/PRKACB/SLC8A1/PLCB1/CLTC/ATP1A1/KL/GNAQ/GNAS	-0.526673177753673
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1862	86/9376	0.87827542277621	PLCB4/CAMK2D/ATF2/PRKACB/CREB5/ADCY4/PLCB1/ATF6B/ATP1A1/CREB1/RAPGEF4/GNAQ/ITPR3/GNAS/KCNN2	-0.564494252718692
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1862	19/9376	0.795070382723727	HYAL2/GNS/HYAL1	-0.445095389687742
NA	NA	hsa04517	IgSF CAM signaling	55/1862	299/9376	0.926252564042691	F11R/TRAF6/PIK3R3/NCK1/ARPC5L/APP/PIK3CA/MPDZ/MYLK/ESAM/MYL12B/MAPK8/PTK2/BCAR1/ARPC1B/ARPC1A/SRGAP2/AKT1/CD2AP/PRKCI/SSX2IP/CTNNB1/GSK3B/MAPK12/TRIO/WASL/AFDN/ERC1/MAG/PLCG1/ACTR2/ACTR3/SPTAN1/VCL/JAM2/RAP1A/MAPK14/MSN/ARF6/ITGA5/BAIAP2/CDC42/JAM3/PAK4/NECTIN2/KDR/MAPK11/NCK2/ROBO3/MYH9/MYL12A/TUBB2A/TJP1/RASA1/PXN	-0.645135934425305
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1862	13/9376	0.774683962653888	LIG4/MRE11	-0.404665472363542
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1862	93/9376	0.866313248559186	PLCB4/PRKACB/ITPR2/ADCY4/PLCB1/ATP1A1/ITPR1/GUCY1B1/GUCY1A1/GNAQ/ITPR3/GNAS/SLC9A1/CALML4/ADRB1/ADRB2	-0.6449492623341
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1862	66/9376	0.839240959541711	NFATC1/HLA-DQB1/NFKB1/STAT1/IFNGR1/SMAD2/RELA/IFNGR2/HLA-DRB1/RORA/IL4R	-0.652397688668892
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1862	20/9376	0.75531686358754	GMDS/CMAS/CYB5R4	-0.545272771114501
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1862	32/9376	0.786788399570355	PGM2/B4GALT1/HK1/GALT/GANC	-0.601394269536042
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1862	38/9376	0.795070382723727	PIK3R3/PIK3CA/NR3C2/ATP1A1/KRAS/NEDD4L	-0.630099991334866
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1862	38/9376	0.795070382723727	TAP1/TAP2/CD40/CIITA/RFX5/ORAI1	-0.630099991334866
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1862	39/9376	0.774683962653888	MTHFD2L/GART/MTHFS/MAT2B/DLD/AHCYL1	-0.701876351595061
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/1862	238/9376	0.888608074808871	MX1/OAS2/OAS1/MX2/OAS3/TRAF6/PIK3R3/ISG15/ADAM17/TBK1/CASP1/NFKB1/HBEGF/PIK3CA/STAT1/SELP/TNFRSF1A/IFIH1/CGAS/CFB/STAT2/ADAR/MAPK8/TLR3/MYD88/EIF2AK2/RPL22L1/IKBKB/MAPK12/IFNAR1/RELA/PLCG1/C1R/MAPK14/IRAK4/NFKBIA/MAP3K7/MAPK11/CHUK/RSL24D1/RPS10/RPL36A	-0.866475909846465
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/1862	86/9376	0.819723727924462	ATP2A2/SLC8A1/ITGAV/SNTB1/CTNNB1/DSP/ITGA5/ATP2A3/ITGA2/LEF1/DAG1/SGCB/CTNNA1/ITGA2B	-0.836026066462303
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1862	28/9376	0.719349393892895	GCNT2/B3GNT5/B4GALT1/A4GALT	-0.740330308591733
NA	NA	hsa04519	Cadherin signaling	73/1862	404/9376	0.909870149206113	PPP1CB/SAV1/FAT4/ARPC5L/MAP2K3/NFKB1/ABI2/NRAS/CDH5/MPDZ/ERBIN/RYK/RAF1/SHOC2/PCDH1/PCDHGA10/EP300/LRP6/MAPK8/PTK2/CSNK1A1/FZD6/PCDHGC3/CTNND1/ARPC1B/ARPC1A/DVL3/APC/CTNNB1/PSEN1/IKBKB/GSK3B/YWHAH/MAPK12/MOB1B/NCSTN/AFDN/YWHAQ/RELA/FZD4/TMC7/ACTR2/TEAD2/YWHAG/MOB1A/WWTR1/KRAS/ACTR3/NCKAP1/VCL/MAPK14/VANGL1/WNT2B/DSP/STK3/ADAM10/CDH24/MYO1E/CDC42/WNT5B/NFKBIA/KDR/LEF1/MAPK11/CHUK/PCDHGB7/CTNNA1/LATS1/PPP1CC/TJP1/PCDH12/AMOTL2/MYO1D	-0.921837950602697
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1862	75/9376	0.805671321160043	ARG2/GOT2/PRPS1/ALDH18A1/IDH1/ACO2/IDH3A/MAT2B/PGAM1/RPE/PYCR2/ASNS	-0.841090230902365
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1862	22/9376	0.686651694170491	CNDP2/ALDH9A1/ALDH3A2	-0.732453215204642
NA	NA	hsa04518	Integrin signaling	26/1862	154/9376	0.850140192782513	PIK3R3/PDGFD/PIK3CA/PDGFB/ITGAV/PTK2/COL4A1/AKT1/LAMB1/CTNNB1/GSK3B/VCAM1/VEGFC/VCL/PARVB/ITGA5/CDC42/LAMA5/COL4A2/KDR/ITGA2/NCK2/PXN/ITGA2B/MTOR/LAMA3	-0.933410865862772
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1862	76/9376	0.795070382723727	HMGCS1/ACSL3/ACADM/SCP2/ACOX1/UBC/CPT1A/ACSL4/ACSL5/PPARD/SLC27A4/ME1	-0.892914616131501
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1862	82/9376	0.798302376149433	HPRT1/DUT/MGST2/CDA/NAT1/CDADC1/CMPK1/DPYD/GMPS/UCKL1/GSTO2/GSTO1/NME7	-0.913158687495913
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1862	226/9376	0.868948604127259	PPP1CB/PDE4B/PIK3R3/GNAI3/NFATC1/CAMK2D/NFKB1/ATP2A2/PRKACB/CREB5/PIK3CA/ADCY4/RAF1/EP300/MAPK8/ARAP3/AKT1/BRAF/AFDN/ATP1A1/CREB1/RELA/RAPGEF4/PDE3A/RAP1A/PDE10A/ACOX1/EDN1/TIAM1/ATP2A3/NFKBIA/GNAS/SLC9A1/PPP1CC/RAPGEF3/ORAI1/CALML4/ADRB1/ADRB2	-0.992716418739485
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1862	48/9376	0.734335839598998	PIK3R3/PLCB4/PIK3CA/PLCB1/AKT1/HK1/ATP1A1	-0.918542384222431
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1862	42/9376	0.719349393892895	DLST/IDO1/ALDH9A1/ECHS1/DLD/ALDH3A2	-0.90739548203799
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1862	36/9376	0.69936746628476	RPA1/MCM7/POLE4/POLE3/POLA1	-0.899608749123725
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	15/1862	95/9376	0.795070382723727	CXCL2/HLA-DQB1/TEK/ATP6V0A1/CXCL3/CSF1/CXCL1/ATP6V1C1/ATP6V1E2/ATP6V1E1/HLA-DRB1/ATP6V1A/ATP6V1B2/IL15/ATP6V1D	-0.999330233012805
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1862	17/9376	0.592405383205914	GLUD1/CA5B	-0.837294151639886
NA	NA	hsa04081	Hormone signaling	37/1862	219/9376	0.850737411042283	PIK3R3/GNAI3/PLCB4/GNB4/PRKACB/ESR2/PIK3CA/ADCY4/ITGAV/SMAD9/PLCB1/ADIPOR2/RAMP3/SMAD1/GNG5/GNA13/STAT5B/STK11/LEPR/HEPH/RAPGEF4/ADIPOR1/OPRL1/SMAD5/SMAD4/JAK2/GNAQ/RAMP2/SLC16A2/NPR2/PTHLH/GNAS/RAPGEF3/ACVR1/ADRB1/GNG12/ADRB2	-1.11259294483113
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1862	31/9376	0.64973493641939	DERA/PGM2/PRPS1/RPE	-0.972361818005634
NA	NA	hsa04981	Folate transport and metabolism	4/1862	31/9376	0.64973493641939	FOLH1/ABCC1/MTHFS/ABCC5	-0.972361818005634
Human Diseases	Immune disease	hsa05310	Asthma	4/1862	32/9376	0.629430719656284	HLA-DQB1/CD40/FCER1A/HLA-DRB1	-1.04524444831201
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1862	45/9376	0.671392767633369	HLA-DQB1/HLA-B/HLA-F/HLA-A/HLA-C/HLA-DRB1	-1.09991509180243
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1862	26/9376	0.581012971990416	PLA2G4A/PLA2G4C/ACOX1	-1.06493065056055
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/1862	26/9376	0.581012971990416	NR5A2/HHEX/HES1	-1.06493065056055
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1862	52/9376	0.677848467322152	PTGS2/PRKACB/PLA2G4A/ADCY4/PLA2G4C/HSD17B7/GNAS	-1.15957974969051
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1862	46/9376	0.656797272684818	CP/CPOX/HEPH/ALAS1/COX10/FXN	-1.1615253844987
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1862	65/9376	0.697215566388499	AGPAT5/DGKE/DGKZ/ALDH9A1/AGPAT1/ALDH3A2/PLPP5/AGPAT4/LCLAT1	-1.21935998835049
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1862	89/9376	0.735514548811837	SDC4/ITGAV/CD47/COL4A1/LAMB1/AGRN/ITGA5/LAMA5/COL4A2/ITGA2/DAG1/ITGA2B/LAMA3	-1.24795506799831
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1862	54/9376	0.652742968532442	HLA-DQB1/HLA-B/HLA-F/CD40/HLA-A/HLA-C/HLA-DRB1	-1.27389390619545
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/1862	79/9376	0.701138016832316	ATP6V0A1/CLTC/ATP6V1C1/ATP6V1E2/ATP6V1E1/NSF/ATP6V1A/ATP6V1B2/NAPA/UNC13B/ATP6V1D	-1.3278612130673
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1862	61/9376	0.660386328819707	TRPM7/SLC8A1/MT1E/SLC11A2/HEPH/ATP1A1/SLC30A1/ATP7A	-1.32464203834532
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1862	36/9376	0.559493973027808	PGM2/GYG1/HK1/GANC	-1.31816430846196
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	41/1862	254/9376	0.812808173414413	NFATC1/PLCB4/CAMK2D/STIM2/PDGFD/ATP2A2/PRKACB/SLC8A1/ITPR2/PDGFB/ADCY4/MYLK/STIM1/PLCB1/FGF18/NOS3/PPP3R1/VDAC3/PPP3CA/ASPH/PLCG1/NFATC3/VDAC1/VDAC2/VEGFC/ITPR1/TACR1/GRPR/ATP2A3/GNAQ/ITPR3/KDR/GNAS/PPP3CB/HRH1/CAMK1D/ORAI1/CALML4/CAMK1/ADRB1/ADRB2	-1.50556180190954
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1862	88/9376	0.686651694170491	CD46/SERPINA5/CFH/CFI/CFB/PROCR/SERPINE1/PROS1/A2M/C1R/CD55/F8	-1.47010198782312
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1862	37/9376	0.544372514297326	GOT2/ADH5/COMT/FAHD1	-1.38229415136933
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1862	51/9376	0.592405383205914	PLA2G4A/AGPS/PLA2G4C/PAFAH1B1/CEPT1/SELENOI	-1.45287746784719
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1862	102/9376	0.691139613740233	PLCB4/ATP2A2/ITPR2/ADCY4/RAB8A/PLCB1/ATP1A1/ITPR1/RAP1A/ATP2A3/GNAQ/ITPR3/GNAS/SLC9A1	-1.56123626791396
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1862	31/9376	0.487301202314542	KL/ALDH9A1/ALDH3A2	-1.42328992195364
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1862	91/9376	0.664014825131903	PDE4B/GNAI3/GNB4/PRKACB/ADCY4/ARRB1/GRK5/GNG5/PDE3A/PDE10A/GNAS/GNG12	-1.60320750831418
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1862	105/9376	0.671392767633369	ATP2A2/PRKACB/SLC8A1/ADCY4/ITGAV/SNTB1/ITGA5/ATP2A3/ITGA2/DAG1/GNAS/SGCB/ITGA2B/ADRB1	-1.68557607316857
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1862	16/9376	0.314715359828142	GOT2	-1.36562967648271
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1862	17/9376	0.296202691602957	CSAD	-1.44576337856405
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/1862	70/9376	0.575479515114316	PTGS2/SULT1A3/MGST2/NAT1/SULT1A1/GSTO2/GSTO1/GSTK1	-1.77462268447076
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1862	27/9376	0.372995982018538	HMGCS1/ECHS1	-1.62408781218719
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1862	50/9376	0.503544575725027	HLA-DQB1/CD40/IL15RA/HLA-DRB1/IL15	-1.75209414335816
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1862	50/9376	0.503544575725027	PECAM1/SELP/CD40/MYD88/VCAM1	-1.75209414335816
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1862	99/9376	0.610357061484881	ATP2A2/SLC8A1/ITGAV/SNTB1/PRKAA1/EDN1/ITGA5/ATP2A3/ITGA2/DAG1/SGCB/ITGA2B	-1.94008389312543
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1862	100/9376	0.604253490870032	ACKR3/TNFSF10/CXCL2/TNFRSF1A/CXCL3/CSF1/TNFRSF10D/CXCL1/TNFRSF1B/TNFRSF10A/TNFRSF10B/CX3CL1	-1.98050801280297
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1862	30/9376	0.335696383816685	PLA2G4A/PLA2G4C	-1.81407081641003
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1862	89/9376	0.565780422162951	GNAI3/GLS/GNB4/PRKACB/ADCY4/GABARAPL2/GNG5/SLC38A2/NSF/GNG12	-2.04883300896697
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1862	63/9376	0.479566262595264	PTGES3/PTGS2/PLA2G4A/PTGR1/PLA2G4C/LTA4H	-2.06314996373819
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	48/1862	323/9376	0.748301536681154	SOS2/HOXD10/PIK3R3/GLS/MCL1/SOS1/NFKB1/PTGS2/NRAS/PIK3CA/PDGFB/RAF1/RASSF1/CASP3/EP300/ABCC1/CDC25B/MDM4/MDM2/SIRT1/SHC1/ABCB1/CDKN1B/HDAC1/DDIT4/APC/CCNG1/HNRNPK/IKBKB/DNMT3A/PLCG1/KRAS/MAPK7/STMN1/BCL2L2/BAK1/NOTCH4/RECK/ITGA5/PAK4/PTEN/E2F3/NOTCH1/UBE2I/ATM/PRKCE/DNMT1/MTOR	-2.2915294668371
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1862	41/9376	0.368447250530507	ALAS1/DLD/PGAM1	-2.01736405580229
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1862	23/9376	0.218932424228273	LNPEP	-1.86688231409478
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	24/1862	183/9376	0.660386328819707	XPO1/RIOK2/HEATR1/NXF1/NMD3/RPP38/CSNK2A1/AK6/XRN1/NOP10/UTP18/CSNK2A2/GNL3L/WDR36/BMS1/RAN/RPP25L/UTP14C/RBM28/UTP14A/SBDS/TCOF1/NOP58/RPP30	-2.30952123879219
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/1862	100/9376	0.553899033297529	IL3RA/HLA-DQB1/CSF1/KITLG/HLA-DRB1/ITGA5/ITGA2/CD55/IL4R/CD22/ITGA2B	-2.2325062096334
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1862	87/9376	0.52090818178451	ATP2A2/SLC8A1/ASPH/ATP1A1/UQCRC2/ATP2A3/UQCRFS1/SLC9A1/COX7B	-2.23477487575559
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1862	191/9376	0.659089758802391	PPP1CB/SOS2/GNAI3/ATF2/GNB4/SOS1/PRKACB/NRAS/CREB5/RAF1/HAT1/SHC1/HDAC1/ATF6B/GNG5/BRAF/CREB1/KRAS/FOSB/HDAC9/GNAS/PPP1CC/CALML4/CAMKK2/GNG12	-2.36950174253558
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1862	43/9376	0.351310169110484	GOT2/AGPAT1/SLC27A4	-2.122269662048
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1862	35/9376	0.287739757557158	GMDS/HK1	-2.10143480263104
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	25/1862	195/9376	0.645569968878239	PIK3R3/PLCB4/CASP1/NFKB1/PIK3CA/SELP/RAF1/PLCB1/HAT1/HDAC1/AKT1/VDAC3/CASP4/MAPK12/RELA/PLCG1/VDAC1/VDAC2/MAPK14/HDAC9/MAP3K7/MAPK11/ITGA2B/AZU1/MTOR	-2.48967527311317
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1862	36/9376	0.279746986513904	KL/RPE	-2.15527542713842
Genetic Information Processing	Translation	hsa03010	Ribosome	29/1862	222/9376	0.657783454775936	MRPL42/MRPL18/MRPL44/MRPL49/MRPL9/RPL22L1/MRPS25/MRPL19/MRPS30/MRPS15/MRPL10/MRPL50/MRPS18C/MRPS22/MRPS11/MRPL16/MRPL32/MRPL1/MRPL43/MRPL22/MRPS7/MRPL53/MRPL46/RSL24D1/RPS10/MRPL17/MRPL34/MRPL4/RPL36A	-2.56869131300038
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1862	29/9376	0.173636060594837	CALML4	-2.21857500640985
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1862	90/9376	0.447595178422246	PRKACB/ADCY4/HMGCR/ABCB1/ATP1A1/GNAS/SLC9A1/KCNN2	-2.62122473086377
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1862	68/9376	0.370253364503696	ALDH1A1/RDH11/ADH5/DHRS4L2/RETSAT	-2.59437055183586
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1862	194/9376	0.596985837199774	CAPZA2/TUBE1/KIF13B/MYO5C/MYL12B/ACTR10/DYNC1LI2/DCTN4/MYO6/HOOK3/KIFAP3/DCTN6/DYNLT1/MYO1E/DCTN5/MYO5A/KIF1B/MYH9/MYL12A/TUBB2A/KIF27/MYO1D/MYO9A	-2.82353002536901
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1862	79/9376	0.382438918272172	MGST2/ADH5/GSTO2/GSTO1/GSTK1/AKR7A2	-2.74385988620763
NA	NA	hsa04382	Cornified envelope formation	26/1862	217/9376	0.603325298103719	PPP2R2D/FURIN/CLDN14/PPP2R5A/COL4A1/SPTLC2/UGCG/PPP2CA/CLDN15/PPP2R5E/CLDN5/BLMH/ABHD5/DSP/PPP2R2A/PPP2R1B/LAMA5/SPTLC1/COL4A2/PPP2R3C/GBA2/TJP1/SLC27A4/OCLN/LAMA3/SPTLC3	-2.9429319681022
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1862	73/9376	0.344893545017142	MGST2/ADH5/GSTO2/GSTO1/GSTK1	-2.7970593358501
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1862	66/9376	0.305178530742441	HSD17B11/COMT/HSD17B7/HSD17B12	-2.8197476128801
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/1862	233/9376	0.583506589895954	SDC4/CAPZA2/LBR/ITGAV/SUN1/SNTB1/COL4A1/PDLIM3/TMEM43/AGRN/ATP1A1/SPTAN1/VCL/DSP/ITGA5/COL4A2/ITGA2/MYH9/DAG1/SYNE1/SGCB/TMOD3/FLNC/NEBL/CSRP2/ITGA2B/AMPD2	-3.20465746476252
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1862	86/9376	0.351310169110484	PLCB4/PRKACB/ADCY4/PLCB1/ITPR3/TAS2R30	-3.00828057641119
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1862	103/9376	0.391102583087399	SLC8A1/COL8A1/COL4A1/SLC36A4/SLC3A2/ATP1A1/SLC38A2/COL4A2	-3.09308956123533
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1862	99/9376	0.356041619199514	HLA-DQB1/CFH/CFI/SELP/CFB/C1R/HLA-DRB1	-3.2063542257309
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	33/1862	298/9376	0.557616476474023	ACKR3/TNFSF10/IL3RA/RELL1/CXCL2/IL27RA/TSLP/TNFRSF1A/IFNGR1/RELT/CXCL3/CD40/CSF1/TNFRSF10D/CXCL1/TNFRSF1B/LEPR/IFNAR1/IL15RA/IFNGR2/ACVR1B/IL33/TNFRSF10A/TNFRSF10B/OSMR/IL13RA1/IL15/CX3CL1/RELL2/IL4R/ACVR1/ACVRL1/GDF11	-3.86324158596653
NA	NA	hsa04082	Neuroactive ligand signaling	16/1862	199/9376	0.404859960381931	GNAI3/PLCB4/GNB4/PRKACB/ADCY4/PLCB1/GNG5/OPRL1/TACR1/GNAQ/GNAS/HRH1/OGFRL1/ADRB1/GNG12/ADRB2	-4.22411003829236
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1862	143/9376	0.176064536966793	HLA-DQB1/CD40/TRIM21/C1R/HLA-DRB1	-4.94230653333223
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1862	370/9376	0.231358318576364	CALCRL/LPAR6/PGRMC1/NMUR2/S1PR1/RXFP1/LEPR/OPRL1/TACR1/S1PR4/EDN1/GRPR/HRH1/OGFRL1/ADRB1/NR3C1/ADRB2	-7.50928700351406
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1862	449/9376	0.0560740062054596	CAMK2D/PRKACB/SLC8A1/ARRB1/CALML4	-10.2034779456832