category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	86/1556	174/9376	2.97822297077682	HSPA5/HSPA1A/HSPA1B/CALR/HSPH1/HERPUD1/DNAJB11/HSP90AB1/DNAJA1/HSP90AA1/HSP90B1/HSPA8/ERN1/BAG2/DNAJA2/PDIA4/OSTC/DNAJC3/STT3B/PDIA3/SKP1/PDIA6/UBQLN2/EDEM2/ERO1B/EDEM3/RAD23B/DERL2/SEC24D/SEC13/XBP1/SEC61B/SYVN1/UBE2G1/DDIT3/MOGS/MAN1A1/EIF2S1/HSPA4L/UBE2D1/UBE2J1/DAD1/SEC23A/TRAM1/CUL1/DDOST/RNF5/OS9/MAGT1/DERL1/HYOU1/SAR1B/PREB/DNAJC10/SEC24A/PPP1R15A/SAR1A/MBTPS1/BCAP29/SEC61G/SSR3/UGGT2/MAPK9/SEL1L/DNAJB2/UBE2J2/CANX/EIF2AK3/DNAJB1/LMAN1/RBX1/UBE2D2/UFD1/SEC23B/SEC24B/SELENOS/PLAA/DERL3/BAX/SSR2/TUSC3/UBQLN1/STT3A/CKAP4/MAPK10/VCP	11.7488621485917
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	136/1556	480/9376	1.70728363324764	HSPA5/PPID/SDHD/CAT/ERN1/CASP7/NDUFA5/CAMK2D/CASP3/IFT57/NDUFC2/TNFRSF1A/NDUFB3/PSMA2/MAP1LC3B/TBK1/TANK/VDAC3/RAB8A/NRBF2/XBP1/CTNNB1/FAS/ATP2A2/PSMC6/KRAS/PSMD12/PSMD11/UBE2G1/DDIT3/GPX8/ACTR10/NFKB1/EIF2S1/PSMA5/PSMD6/UBE2L6/UBE2J1/PSMB5/ATXN2/PSMA3/C9orf72/TARDBP/PRNP/SOD1/WNT6/ATG101/PSMB2/PSMA1/SDHB/PPP3CC/DERL1/SDHC/CALM2/TUBB2A/ATP5F1C/CSF1/NDUFB6/NDUFA12/NDUFV2/DCTN4/WIPI1/HTT/PSMA6/NDUFA7/MFN1/VDAC1/NDUFB8/PSMB6/MAP2K1/DCTN6/UQCRFS1/FZD10/PSMD2/RAB1A/PARK7/UQCRH/PSMB3/UQCRC2/RAB5A/ATXN2L/VDAC2/MAPK9/CYCS/NRAS/NDUFA6/NDUFB5/UBE2J2/EIF2AK3/GPX3/PSMC2/HIP1/ATP5MC3/CHMP2B/RAF1/ATP5MC1/CSNK1A1/NDUFA8/CSNK2A1/ZFYVE1/NDUFS3/FZD3/SLC25A5/UCHL1/COX7A2L/BAX/CSNK1E/CALM1/CCS/HTRA2/VAPB/CDK5/UBB/PSMD9/MAPT/ATXN1/NDUFA2/CALM3/WNT3A/MAP2K2/FZD2/NDUFA4/PPP3CA/NDUFS4/PLCB3/COX7B/HSD17B10/PSMC4/CSNK2B/UBE2L3/BECN1/PSEN1/MAPK10/DNAH11/ATG13/VCP	7.09584136891366
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	56/1556	142/9376	2.3763351316123	UBE2H/SKP1/CDC26/UBE2N/UBE2A/BIRC2/SYVN1/UBE2G1/UBE2W/RNF7/UBE2B/UBE2D1/UBE2L6/CDC16/UBE2J1/SOCS1/CUL1/MDM2/UBA2/UBE2Z/RCHY1/UBE2S/NEDD4/SIAH1/UBE2I/SAE1/CUL2/ANAPC10/SMURF1/BIRC6/CDC27/UBE2Q1/UBE2Q2/UBA3/HERC4/TRAF6/CUL3/UBE2J2/UBE2F/ELOC/PML/RBX1/UBE2E3/UBE2D2/MID1/FBXW7/CUL4B/UBB/ANAPC16/SOCS3/UBE2M/ITCH/KLHL13/ANAPC13/UBE2L3/UBE4A	7.3715784315959
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	83/1556	268/9376	1.86617043318114	HSPA5/DUSP1/GNAI3/SDHD/ERN1/NDUFA5/CAMK2D/CASP3/NDUFC2/NDUFB3/PSMA2/SLC39A14/VDAC3/XBP1/PSMC6/PSMD12/PSMD11/UBE2G1/DDIT3/EIF2S1/PSMA5/PSMD6/UBE2L6/UBE2J1/GNAS/PSMB5/PSMA3/SLC39A7/SOD1/PSMB2/PSMA1/SDHB/SDHC/CALM2/TUBB2A/ATP5F1C/NDUFB6/NDUFA12/NDUFV2/PSMA6/NDUFA7/GNAI1/MFN1/VDAC1/NDUFB8/PSMB6/UQCRFS1/PSMD2/PARK7/UQCRH/PSMB3/UQCRC2/VDAC2/MAPK9/CYCS/NDUFA6/NDUFB5/UBE2J2/EIF2AK3/PSMC2/SLC39A1/ATP5MC3/ATP5MC1/NDUFA8/TXN/NDUFS3/SLC25A5/UCHL1/COX7A2L/BAX/CALM1/HTRA2/UBB/PSMD9/MAPT/NDUFA2/CALM3/NDUFA4/NDUFS4/COX7B/PSMC4/UBE2L3/MAPK10	6.41721070045505
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	104/1556	368/9376	1.70291717894266	HSPA5/SDHD/CAT/ERN1/SRSF7/HNRNPA2B1/HNRNPA3/NDUFA5/CASP3/NDUFC2/TNFRSF1A/NDUFB3/PSMA2/MAP1LC3B/TBK1/TANK/UBQLN2/RAB8A/SEC13/NRBF2/XBP1/PSMC6/PSMD12/PSMD11/SRSF3/DDIT3/GPX8/ACTR10/EIF2S1/PSMA5/PSMD6/PSMB5/ATXN2/PSMA3/NUP54/C9orf72/TARDBP/SOD1/ATG101/PSMB2/PSMA1/SDHB/PPP3CC/DERL1/SDHC/NUP98/TUBB2A/ATP5F1C/NXT1/NDUFB6/RANBP2/NDUFA12/NDUFV2/DCTN4/WIPI1/PSMA6/NDUFA7/NUP58/HNRNPA1/VDAC1/NDUFB8/SETX/PSMB6/DCTN6/UQCRFS1/PSMD2/RAB1A/UQCRH/PSMB3/UQCRC2/RAB5A/ATXN2L/CYCS/NDUFA6/NDUFB5/NUP160/RAE1/EIF2AK3/GPX3/PSMC2/ATP5MC3/CHMP2B/ATP5MC1/NDUFA8/NDUFS3/COX7A2L/BAX/CCS/NUP214/VAPB/UBQLN1/PSMD9/NUP107/NDUFA2/NDUFA4/PPP3CA/NDUFS4/COX7B/PSMC4/NUP37/BECN1/DNAH11/ATG13/VCP	6.13622019949272
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	77/1556	248/9376	1.87088481631976	HSP90AB1/RHOB/HSP90AA1/HSP90B1/ACBD3/CASP7/CASP3/TNFRSF1A/SKP1/DYNLT3/RIPK2/DYNLL1/ARF6/RAB9A/CTNNB1/BIRC2/EXOC5/ACTR10/NFKB1/PIK3CA/SNX18/WASL/KPNA1/EXOC2/PIK3C2A/DYNLT1/TUBB2A/ARL8B/CDC42/JUN/NFKBIA/MYL12B/DYNC2LI1/RRAS/DCTN4/ARF1/CASP4/CYFIP1/KPNA4/ARPC5L/MAP2K1/DCTN6/WASF3/M6PR/RAB5A/TRAF6/MAPK9/CYCS/MYC/DYNC1LI2/KPNA3/CSE1L/ACTR2/ARPC3/RAB7A/RAF1/ARPC1B/ARL8A/TXN/ACTR3/CYTH2/IKBKB/BAX/RAB5B/PLEKHM1/ABI1/MAP2K2/RHOA/IRAK4/SNX33/ARPC4/TLR4/MAPK10/BRK1/NCKAP1/FOS/MLKL	6.19991594328549
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	58/1556	169/9376	2.06799409805144	ERN1/CALCOCO2/PTEN/MAP1LC3B/TBK1/TANK/RAB8A/SH3GLB1/NRBF2/KRAS/EIF2S1/NBR1/PIK3CA/SUPT20H/C9orf72/IRS1/LAMP2/ATG101/ATG4C/RAB33B/PPP2CA/ATG5/RRAS/HIF1A/WIPI1/BIRC6/MAP2K1/RAB1A/IGBP1/TRAF6/MAPK9/NRAS/GABARAPL2/EIF2AK3/RAB7A/PPP2CB/RAF1/RHEB/BNIP3/ZFYVE1/STX17/VMP1/RRAGC/GORASP1/CAMKK2/DDIT4/PLEKHM1/GORASP2/UBB/STK11/MAP2K2/ATG4A/BECN1/PRKAA1/MAPK10/PIK3R3/ATG13/MTMR4	6.24942688528953
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	34/1556	78/9376	2.62659020499637	HSPD1/TOB1/C1D/BTG3/PNPT1/HSPA9/DDX6/LSM1/XRN1/CNOT10/CNOT2/EXOSC10/EXOSC3/CNOT9/TOB2/BTG2/LSM5/EXOSC7/LSM8/LSM6/DCP1A/CNOT4/TENT4B/PAN3/LSM2/PFKM/XRN2/PABPC5/EXOSC8/TENT4A/BTG1/MPHOSPH6/CNOT6/CNOT8	6.43454349899969
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	107/1556	388/9376	1.66172846049877	PPID/SDHD/ERN1/CASP7/NDUFA5/CASP3/NDUFC2/TNFRSF1A/NDUFB3/PSMA2/SLC39A14/VDAC3/NRBF2/XBP1/CTNNB1/FAS/ATP2A2/PSMC6/EIF2AK2/KRAS/PSMD12/PSMD11/DDIT3/NFKB1/EIF2S1/PSMA5/PIK3CA/PSMD6/PSMB5/PSMA3/SLC39A7/IRS1/WNT6/ATG101/PSMB2/PSMA1/SDHB/PPP3CC/SDHC/CALM2/TUBB2A/ATP5F1C/CSF1/NDUFB6/RTN3/NDUFA12/NDUFV2/WIPI1/PSMA6/NDUFA7/ADAM17/IDE/VDAC1/NDUFB8/PSMB6/MAP2K1/UQCRFS1/FZD10/PSMD2/UQCRH/PSMB3/NAE1/UQCRC2/VDAC2/MAPK9/CYCS/NRAS/NDUFA6/NDUFB5/EIF2AK3/PSMC2/SLC39A1/ATP5MC3/APOE/RAF1/ATP5MC1/CSNK1A1/NDUFA8/CSNK2A1/NDUFS3/FZD3/SLC25A5/IKBKB/COX7A2L/CSNK1E/CALM1/CDK5/PSMD9/MAPT/NDUFA2/CALM3/WNT3A/MAP2K2/FZD2/NDUFA4/PPP3CA/NDUFS4/PLCB3/COX7B/HSD17B10/PSMC4/CSNK2B/BECN1/PSEN1/MAPK10/PIK3R3/ATG13	5.93815053097179
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	40/1556	108/9376	2.23174331143483	XPO1/SUMO1/THOC7/DDX39B/NMD3/SEC13/RAN/SUMO2/EIF4A3/KPNA1/NUP54/RNPS1/TNPO1/NUP98/MAGOH/ACIN1/UBE2I/NXT1/RANBP2/NUP58/KPNA4/NCBP2/SAP18/NUP160/RAE1/KPNA3/SENP2/THOC1/CSE1L/XPOT/XPO4/MAGOHB/THOC3/UPF1/NUP214/NUP107/THOC5/NUP37/AHCTF1/KPNA2	5.74283231958444
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	52/1556	157/9376	1.99577554729586	SDHD/ERN1/CASP7/NDUFA5/CASP3/NDUFC2/TNFRSF1A/NDUFB3/XBP1/FAS/MLX/DDIT3/NFKB1/EIF2S1/PIK3CA/IRS1/SDHB/SDHC/CDC42/JUN/NDUFB6/NDUFA12/NDUFV2/NDUFA7/NDUFB8/ADIPOR1/UQCRFS1/UQCRH/PRKAG1/UQCRC2/MAPK9/CYCS/NDUFA6/NDUFB5/EIF2AK3/NDUFA8/PRKAB2/NDUFS3/IKBKB/COX7A2L/BAX/SOCS3/NDUFA2/NDUFA4/NDUFS4/ITCH/COX7B/PRKAA1/MAPK10/ADIPOR2/PIK3R3/FOS	5.61250103444593
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	67/1556	224/9376	1.80233198677929	CALR/XPO1/ZFP36/TNFRSF1A/CDC26/NFYB/PTEN/FOSL1/MSX1/VDAC3/RAN/SMAD4/NFATC1/B2M/KRAS/CCND2/ADCY3/NFKB1/RB1/PIK3CA/ADCY6/CDC16/NRP1/ELK4/PPP3CC/ETS2/MAP3K14/RANBP1/TGFBR2/TBPL1/JUN/NFKBIA/STAT5B/CCND3/ANAPC10/BUB3/VDAC1/CDC27/MAP2K1/HLA-F/IL15RA/VDAC2/MAPK9/MYC/NRAS/CDK2/CANX/EP300/JAK3/KAT2A/SLC25A5/ADCY9/IKBKB/BAX/ANAPC16/CREB3L4/MAP2K2/PPP3CA/ATF2/ANAPC13/TGFB3/MAPK10/PIK3R3/CRTC3/STAT5A/CDKN2B/FOS	5.42134653056881
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	72/1556	250/9376	1.73540359897172	HSPA1A/HSPA1B/SNX3/SPART/HSPA8/SNX1/ARF4/CHMP5/ARF6/RAB8A/SH3GLB1/ZFYVE16/SNX2/RAB11FIP2/VPS29/WASL/VPS36/VPS26A/EHD1/MDM2/CAPZA2/EPS15L1/RAB10/TSG101/TGFBR2/NEDD4/CDC42/CAPZA1/SMURF1/RUFY1/GBF1/ARF1/ARPC5L/RUFY2/HLA-F/ARFGAP3/CHMP1B/RAB5A/TRAF6/STAM2/PDCD6IP/SNF8/ACTR2/ARPC3/PARD6G/RAB7A/VPS37B/VPS25/CHMP2B/PML/RAB35/ARPC1B/GRK5/ARFGAP2/ACTR3/WASHC4/ACAP2/CLTA/CYTH2/ASAP1/SNX4/CHMP4A/PIP5K1A/RAB5B/RHOA/EPS15/CAV2/ITCH/SH3KBP1/ARPC4/VPS37A/RNF41	5.25705573048215
Human Diseases	Infectious disease: viral	hsa05162	Measles	45/1556	136/9376	1.99380009073038	HSPA1A/HSPA1B/CDKN1B/OAS1/MX1/OAS2/HSPA8/CASP3/IRF7/CD46/TBK1/STAT2/RAB9A/FAS/EIF2AK2/CCND2/NFKB1/EIF2S1/PIK3CA/IFNAR1/BBC3/ADAR/RCHY1/JUN/NFKBIA/STAT5B/CCND3/STAT1/MSN/TRAF6/MAPK9/CYCS/OAS3/CDK2/CSNK2A1/JAK3/IKBKB/BAX/IRAK4/CSNK2B/TLR4/MAPK10/PIK3R3/STAT5A/FOS	5.20738345171799
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	24/1556	56/9376	2.58244583180316	HSPA1A/HSPA1B/SEC22B/HSPD1/HSPA8/CASP7/CASP3/CLK4/CXCL2/CXCL1/NFKB1/HBS1L/SAR1B/NFKBIA/SAR1A/ARF1/RAB1A/CLK1/CYCS/CXCL3/BNIP3/BCL2L13/TLR4/VCP	5.29787818257261
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	82/1556	308/9376	1.60424665308984	SDHD/ERN1/NDUFA5/CASP3/IFT57/NDUFC2/NDUFB3/PSMA2/VDAC3/POLR2K/SIN3A/NRBF2/PSMC6/PSMD12/PSMD11/GPX8/ACTR10/PSMA5/PSMD6/PSMB5/BBC3/PSMA3/POLR2C/SOD2/SOD1/ATG101/PSMB2/PSMA1/SDHB/SDHC/TUBB2A/ATP5F1C/TBPL1/NDUFB6/NDUFA12/NDUFV2/DCTN4/WIPI1/HDAC1/HTT/PSMA6/NDUFA7/VDAC1/NDUFB8/SP1/PSMB6/DCTN6/UQCRFS1/PSMD2/UQCRH/PSMB3/UQCRC2/VDAC2/MAPK9/CYCS/NDUFA6/NDUFB5/GPX3/POLR2J/PSMC2/HIP1/ATP5MC3/ATP5MC1/EP300/NDUFA8/NDUFS3/CLTA/SLC25A5/COX7A2L/BAX/PSMD9/CREB3L4/NDUFA2/NDUFA4/NDUFS4/PLCB3/COX7B/PSMC4/BECN1/MAPK10/DNAH11/ATG13	4.8097323992988
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	36/1556	105/9376	2.06595666544253	CALCOCO2/MAP1LC3B/TBK1/MTX2/KRAS/EIF2S1/NBR1/OPA1/SIAH1/JUN/RRAS/HIF1A/SMURF1/ARIH1/MFN1/SP1/RAB5A/MAPK9/NRAS/GABARAPL2/MTX3/RHOT1/EIF2AK3/RABGEF1/RAB7A/BNIP3/CSNK2A1/TOMM70/RAB5B/MUL1/UBB/BCL2L13/CSNK2B/BECN1/MAPK10/VCP	4.89956999751461
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	74/1556	275/9376	1.6214629586352	HSPA5/HSPA1A/HSPA1B/STIP1/SDHD/HSPA8/C7/NDUFA5/CASP3/NDUFC2/NDUFB3/PSMA2/VDAC3/PSMC6/PSMD12/PSMD11/DDIT3/EIF2S1/PSMA5/PIK3CA/PSMD6/PSMB5/PSMA3/PRNP/SOD1/PSMB2/PSMA1/SDHB/PPP3CC/SDHC/TUBB2A/ATP5F1C/NDUFB6/NDUFA12/NDUFV2/PSMA6/NDUFA7/VDAC1/NDUFB8/PSMB6/UQCRFS1/PSMD2/UQCRH/NOTCH1/PSMB3/UQCRC2/VDAC2/MAPK9/CYCS/NDUFA6/NDUFB5/EIF2AK3/PSMC2/ATP5MC3/ATP5MC1/NDUFA8/CSNK2A1/NDUFS3/SLC25A5/COX7A2L/BAX/PSMD9/CREB3L4/NDUFA2/CAV2/NDUFA4/PPP3CA/NDUFS4/ATF2/COX7B/PSMC4/CSNK2B/MAPK10/PIK3R3	4.66577826861173
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	53/1556	180/9376	1.77423593259069	CALR/OAS1/IFNGR1/OAS2/SRSF7/CASP3/PDIA3/TNFRSF1A/IRF7/BST2/PPP1CB/TBK1/EIF2B2/SRSF9/STAT2/SRSF2/CGAS/FAS/BIRC2/B2M/EIF2AK2/SRSF1/SRSF3/NFKB1/EIF2S1/PIK3CA/PPP1CC/IFNAR1/TAP1/IFNGR2/SRSF6/NFKBIA/SP100/STAT1/HLA-F/TRAF6/ZC3HAV1/CYCS/OAS3/TICAM1/TLR3/SRSF5/RHEB/PML/NECTIN2/HCFC2/IKBKB/BAX/PTPN11/SOCS3/RNASEL/IRAK4/PIK3R3	4.67839786204817
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	49/1556	163/9376	1.81140883498667	CASP3/IRF7/TBK1/VDAC3/SOS1/STAT2/FAS/SMAD4/NFATC1/KRAS/NFKB1/RB1/PIK3CA/IFNAR1/DDX3X/TGFBR2/JUN/NFKBIA/STAT5B/YWHAQ/STAT1/MAP2K1/TRAF6/MAPK9/CYCS/MYC/NRAS/CDK2/TICAM1/EGR3/TLR3/RAF1/STAT6/EP300/JAK3/IKBKB/BAX/PCNA/CREB3L4/MAP2K2/IRAK4/ATF2/TGFB3/TLR4/MAPK10/PIK3R3/STAT5A/YWHAB/FOS	4.66143955199553
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	30/1556	83/9376	2.17796636417134	SKP1/AEBP2/USP45/UBE2D1/MAX/PCGF5/PHC2/MGA/TFDP1/SCML1/KDM2A/HDAC1/MTF2/PHC3/SUZ12/MBD5/EZH2/E2F6/EP300/UBE2D2/CBX7/PCGF2/L3MBTL3/CBX8/EED/RBBP7/FOXK2/RNF2/CSNK2B/FBRSL1	4.80818340654389
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/1556	46/9376	2.61987258298871	PSMA2/PSMB9/PSMC6/PSMD12/PSMD11/PSMA5/PSMD6/PSMB5/PSMA3/PSMB2/PSMA1/PSMA6/PSMB6/PSMD2/PSMB3/PSMC2/PSMF1/PSMD9/PSMB8/PSMC4	4.91253895049342
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	56/1556	196/9376	1.72163055453544	IFNGR1/ZFP36/CASP3/TNFRSF1A/IRF7/MAP1LC3B/TBK1/STAT2/CTNNB1/FAS/CXCL2/NFATC1/EIF2AK2/KRAS/CXCL1/GNG12/NFKB1/RB1/PIK3CA/IFNAR1/CLEC2B/GNB4/FGF2/PPP3CC/CALM2/JUN/NFKBIA/STAT1/HIF1A/MAP2K1/HLA-F/MAPK9/CYCS/MYC/NRAS/CXCL3/TICAM1/TLR3/RAF1/EP300/IL6ST/GNG5/IKBKB/MICB/BAX/CALM1/GNG11/UBB/CALM3/MAP2K2/PPP3CA/ANGPT2/BECN1/MAPK10/PIK3R3/FOS	4.55416400531191
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	38/1556	119/9376	1.92417532565725	CASP7/CASP3/TNFRSF1A/VCAM1/FAS/CXCL2/BIRC2/CXCL1/NFKB1/PIK3CA/CEBPB/DNM1L/CYLD/JUNB/MAP3K14/JUN/CSF1/NFKBIA/IL18R1/ADAM17/MAP2K1/MAP3K8/MAPK9/CXCL3/TRAF1/DAB2IP/JAG1/IKBKB/LIF/CREB3L4/SOCS3/ITCH/ATF2/MAPK10/PIK3R3/RHBDF1/FOS/MLKL	4.52563762163407
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	62/1556	227/9376	1.64578779882903	SDHD/CAT/GSTM3/NDUFA5/PTK2/HGF/NDUFC2/NDUFB3/PTEN/VDAC3/SOS1/CBR1/KRAS/ABL1/NFKB1/PIK3CA/ACP1/SOD2/SOD1/PRKD3/SDHB/SDHC/MAP3K14/ATP5F1C/JUN/NDUFB6/NFKBIA/NDUFA12/NDUFV2/HIF1A/NDUFA7/VDAC1/NDUFB8/MAP2K1/UQCRFS1/UQCRH/ARNT/UQCRC2/VDAC2/MAPK9/NRAS/NDUFA6/NDUFB5/ATP5MC3/RAF1/ATP5MC1/NDUFA8/NDUFS3/SLC25A5/IKBKB/COX7A2L/PTPN11/NDUFA2/EPHX1/MAP2K2/AKR1A1/NDUFA4/NDUFS4/COX7B/MAPK10/PIK3R3/FOS	4.39342288824366
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	43/1556	144/9376	1.79934304484433	ERN1/GTF2B/PSMA2/VDAC3/NRBF2/XBP1/ATP2A2/PSMC6/PSMD12/PSMD11/PSMA5/PIK3CA/PSMD6/PSMB5/ATXN2/PSMA3/OPA1/ATG101/PSMB2/PSMA1/TBPL1/WIPI1/PSMA6/VDAC1/SP1/PSMB6/PSMD2/PSMB3/ATXN2L/VDAC2/MAPK9/CYCS/PSMC2/SLC25A5/PUM2/PSMD9/ATXN1/PLCB3/PSMC4/BECN1/MAPK10/PIK3R3/ATG13	4.31175034330255
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	49/1556	173/9376	1.70670312198166	OAS1/IFNGR1/MX1/XPO1/OAS2/CALCOCO2/DNAJC3/CASP3/TNFRSF1A/IRF7/TBK1/RSAD2/STAT2/FAS/EIF2AK2/NFKB1/EIF2S1/PIK3CA/IFNAR1/KPNA1/ADAR/IFNGR2/NUP98/NXT1/NFKBIA/CCND3/STAT1/VDAC1/PABPN1/MAP2K1/CYCS/OAS3/TICAM1/RAE1/DNAJB1/TLR3/RAF1/PML/EP300/SLC25A5/IKBKB/BAX/SOCS3/RNASEL/MAP2K2/IRAK4/TLR4/PIK3R3/KPNA2	4.18487421042406
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	30/1556	90/9376	2.00856898029135	CAT/KRAS/ADCY3/EIF4E/NFKB1/PIK3CA/ADCY6/SOD2/IRS1/ATG101/SIRT1/ATG5/ADIPOR1/SESN2/PRKAG1/NRAS/SESN1/RHEB/PRKAB2/CAMKK2/ADCY9/BAX/CREB3L4/STK11/ATF2/EIF4E2/PRKAA1/ADIPOR2/PIK3R3/ATG13	4.28844238618801
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	58/1556	216/9376	1.61801390079025	HSPA5/HSPA1A/HSPA1B/HSP90AB1/HSPD1/HSP90AA1/HSP90B1/HSPA8/ERN1/HSPA4/CASP7/PTK2/CAMK2D/CASP3/TNFRSF1A/IRF7/TBK1/TANK/VCAM1/XBP1/FAS/CXCL2/NFATC1/KRAS/CXCL1/DDIT3/NFKB1/EIF2S1/PIK3CA/SOD2/PPP3CC/CALM2/CDC42/JUN/NFKBIA/HSPA2/TRAF6/ABCA1/MAPK9/CYCS/NRAS/CXCL3/TICAM1/EIF2AK3/IKBKB/BAX/CALM1/RAP1A/CALM3/CD36/RHOA/PPP3CA/PLCB3/IRAK4/TLR4/MAPK10/PIK3R3/FOS	4.09887279326063
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/1556	158/9376	1.71618235657805	CDKN1B/GADD45A/WEE1/SKP1/CDC26/CCNH/SMAD4/CCND2/ABL1/RB1/CDC16/CUL1/MDM2/PPP2CA/TFDP1/CCND3/YWHAQ/ANAPC10/HDAC1/BUB3/CDC27/SMC3/MYC/CDK2/NDC80/ESCO1/PPP2CB/MCM3/RAD21/EP300/RBX1/ORC3/PPP2R5E/STAG2/CDC14B/PCNA/MAD2L2/MAD2L1BP/ANAPC16/PDS5B/PPP2R5C/ANAPC13/TGFB3/YWHAB/CDKN2B	4.04968149332029
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	55/1556	205/9376	1.61665308169791	CALR/CDKN1B/OAS1/OAS2/NFKBIE/GADD45A/SAP30/CASP3/PDIA3/IRF7/TBK1/STAT2/SIN3A/FAS/B2M/PSMC6/EIF2AK2/CCND2/PSMD12/PSMD11/NFKB1/RB1/PIK3CA/PSMD6/IFNAR1/TAP1/MDM2/MAP3K14/NEDD4/HES1/JUN/NFKBIA/CCND3/STAT1/HDAC1/PSMD2/HLA-F/TRAF6/MAPK9/CYCS/OAS3/MYC/CDK2/PSMC2/SNW1/JAK3/ISG15/IKBKB/BAX/SAP30L/IRAK4/PSMC4/VIM/MAPK10/PIK3R3	3.98195683601865
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	55/1556	205/9376	1.61665308169791	SDHD/NDUFA5/MPC2/CAMK2D/NDUFC2/NDUFB3/COL3A1/PPP1CB/PTEN/PDK4/VDAC3/AGTR1/COL1A2/ATP2A2/GFPT1/MPC1/NFKB1/PIK3CA/PPP1CC/IRS1/SDHB/SDHC/TGFBR2/ATP5F1C/NDUFB6/NDUFA12/NDUFV2/NDUFA7/VDAC1/NDUFB8/SP1/UQCRFS1/UQCRH/PDHB/UQCRC2/VDAC2/MAPK9/NDUFA6/REN/NDUFB5/ATP5MC3/ATP5MC1/NDUFA8/NDUFS3/SLC25A5/COX7A2L/NDUFA2/CD36/NDUFA4/NDUFS4/PLCB3/COX7B/TGFB3/MAPK10/PIK3R3	3.98195683601865
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	44/1556	156/9376	1.69955836793883	OAS1/IFIT1/MX1/OAS2/CASP3/TNFRSF1A/IRF7/TBK1/RSAD2/SOS1/STAT2/CTNNB1/FAS/EIF2AK2/KRAS/NFKB1/EIF2S1/RB1/PIK3CA/IFNAR1/PPP2CA/NFKBIA/YWHAQ/STAT1/MAP2K1/TRAF6/CYCS/OAS3/MYC/NRAS/CDK2/TICAM1/PPP2CB/TLR3/CLDN12/RAF1/PPP2R2D/IKBKB/BAX/SOCS3/RNASEL/MAP2K2/PIK3R3/YWHAB	3.93013847402768
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	32/1556	103/9376	1.87206429231038	PPP1CB/ETF1/DDX39B/CPSF6/PAPOLA/PPP1CC/EIF4A3/TARDBP/RNGTT/RNPS1/HBS1L/MAGOH/ACIN1/PPP2CA/NXT1/PABPN1/PELO/WDR33/NCBP2/SAP18/SSU72/PPP2CB/MAGOHB/PAPOLG/PPP2R2D/PPP2R5E/UPF1/PABPC5/CSTF2/PPP2R5C/CPSF7/CSTF2T	3.96957530003786
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	56/1556	214/9376	1.57682050789227	CALR/GNAI3/WEE1/PTK2/CASP3/PDIA3/TNFRSF1A/SKP1/BST2/TRIM5/AP1G1/TBK1/CGAS/FAS/NFATC1/B2M/KRAS/GNG12/NFKB1/PIK3CA/RNF7/GNB4/TAP1/CUL1/PPP3CC/CALM2/JUN/NFKBIA/GNAI1/MAP2K1/HLA-F/TRAF6/MAPK9/CYCS/NRAS/ELOC/RAF1/RBX1/GNG5/IKBKB/BAX/CUL4B/CALM1/GNG11/CFL2/AP1S2/CALM3/MAP2K2/PPP3CA/SAMHD1/IRAK4/TLR4/APOBEC3G/MAPK10/PIK3R3/FOS	3.80749633137653
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	22/1556	62/9376	2.13815407579401	MAML2/HEYL/DTX3L/NUMB/HEY2/HES1/HDAC1/ADAM17/NOTCH1/NRARP/NOTCH2/JAG1/EP300/DTX3/SNW1/DLL1/KAT2A/SPEN/ATXN1/ITCH/PSEN1/TLE1	4.01065997489475
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	50/1556	187/9376	1.61115158846899	HSP90AB1/OAS1/HSP90AA1/OAS2/IRF7/SUGT1/MAP1LC3B/RIPK2/TBK1/TANK/VDAC3/STAT2/CXCL2/BIRC2/CXCL1/NFKB1/IFNAR1/DNM1L/JUN/NFKBIA/ATG5/STAT1/GBP1/TP53BP1/ANTXR2/CASP4/GBP3/MFN1/VDAC1/GBP2/PKN2/TRAF6/VDAC2/MAPK9/OAS3/NEK7/CXCL3/GABARAPL2/TICAM1/NLRP1/TRIP6/TXN/IKBKB/IFI16/RNASEL/RHOA/PLCB3/IRAK4/TLR4/MAPK10	3.76550024672172
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1556	32/9376	2.63624678663239	CASP7/CASP3/TNFRSF1A/BIRC2/BBC3/PMAIP1/BIRC6/MAPK9/CYCS/BAX/BOK/HTRA2/BECN1/MAPK10	4.13565630051141
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	18/1556	47/9376	2.3077175518241	ADH1B/ADH5/ALDH3A2/GLO1/DLD/ACYP1/MDH1/ACSS2/ALDH2/ALDH7A1/ACYP2/HAGH/PDHB/FH/GRHPR/ALDH9A1/LDHB/AKR1A1	4.00896618614151
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1556	133/9376	1.72163055453544	KLF2/CDKN1B/CAT/GADD45A/PTEN/PLK2/SOS1/SMAD4/KRAS/CCND2/PLK3/PIK3CA/SOD2/IRS1/SIRT1/MDM2/TGFBR2/MAP2K1/PRKAG1/MAPK9/NRAS/GABARAPL2/CDK2/CCNG2/RAF1/EP300/SETD7/BNIP3/PRKAB2/IKBKB/CSNK1E/STK11/MAP2K2/TGFB3/PRKAA1/MAPK10/PIK3R3/CDKN2B	3.73870600326526
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	35/1556	120/9376	1.75749785775493	NFKBIE/CAMK2D/RIPK2/SOS1/KRAS/ABL1/NFKB1/PIK3CA/IRS1/CALM2/CDC42/JUN/NFKBIA/NGF/MAP2K1/TRAF6/MAPK9/NRAS/RAF1/IKBKB/BAX/CALM1/PTPN11/RAP1A/CALM3/MAP2K2/FRS2/RHOA/BEX3/IRAK4/KIDINS220/SORT1/PSEN1/MAPK10/PIK3R3	3.72518132434812
Genetic Information Processing	Transcription	hsa03040	Spliceosome	61/1556	243/9376	1.51262602219472	HSPA1A/HSPA1B/SNRPA1/HSPA8/SRSF7/DDX5/HNRNPA3/TRA2A/THOC7/DDX39B/SF3B1/PHF5A/SRSF9/BCAS2/SRSF2/SF3B6/CWC15/SRSF1/SRSF10/SRSF3/BUD31/EIF4A3/SF3B3/SNRPF/PRPF38A/SNRNP40/HNRNPU/WBP11/MAGOH/ACIN1/CRNKL1/SRSF6/HNRNPA1/LSM5/LSM8/NCBP2/LSM6/SNRPC/THOC1/RBMX/RBM17/SNRPD1/PPIH/SF3B5/RBM22/SRSF5/MAGOHB/SNRPB/SNW1/SMNDC1/THOC3/PPIL1/SF3A3/LSM2/SF3B4/SNRPG/HNRNPK/SNRPE/THOC5/TRA2B/SNRPD3	3.611470853877
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	43/1556	157/9376	1.65035285641773	PPID/GADD45A/PPP1CB/PTEN/ZFP36L1/VDAC3/NFATC1/KRAS/CCND2/NFKB1/RB1/PIK3CA/PPP1CC/SIRT1/MDM2/PPP3CC/CALM2/TGFBR2/CCND3/HIPK1/RRAS/HUS1/VDAC1/MAP2K1/HLA-F/VDAC2/MYC/NRAS/CDK2/NBN/RAD50/RAF1/MRE11/RHEB/SLC25A5/CALM1/CALM3/MAP2K2/RAD1/PPP3CA/TGFB3/PIK3R3/CDKN2B	3.66559119603976
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	25/1556	77/9376	1.95639835742664	CDKN1B/GADD45A/SOS1/SMAD4/KRAS/ABL1/NFKB1/RB1/PIK3CA/MDM2/TGFBR2/NFKBIA/STAT5B/HDAC1/MAP2K1/MYC/NRAS/RAF1/IKBKB/BAX/PTPN11/MAP2K2/TGFB3/PIK3R3/STAT5A	3.75883375540074
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/1556	73/9376	1.98105433672571	MX1/XPO1/BST2/TRIM5/CPSF6/ELL2/RAN/FEZ1/CCNT2/TSG101/RANBP2/ELL/NELFCD/PDCD6IP/MDFIC/MLLT3/EP300/PSIP1/CDK9/KAT2A/CHMP4A/SAMHD1/CPSF7/APOBEC3G	3.75344485340533
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	59/1556	235/9376	1.51283706175135	SDHD/NDUFA5/NDUFC2/NDUFB3/ZNF516/SOS1/KRAS/ADCY3/COA5/ADCY6/COX14/GNAS/SMARCE1/COA3/SDHB/PRKG1/SDHC/ATP5F1C/COX19/NDUFB6/KDM1A/NDUFA12/NDUFV2/NDUFA7/COA1/NDUFB8/UQCRFS1/ACSL3/COA4/COX11/UQCRH/COA6/PRKAG1/UQCRC2/NRAS/NDUFA6/NDUFB5/KDM3B/CPT1A/ATP5MC3/RHEB/ATP5MC1/NDUFA8/NDUFAF1/PRKAB2/NDUFS3/ARID1B/ADCY9/COX7A2L/SMARCD1/CREB3L4/NDUFA2/FRS2/NDUFA4/NDUFS4/ATF2/COX7B/PRKAA1/CNR1	3.55143228109483
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/1556	70/9376	1.97987513771575	HGF/SOS1/KRAS/PIK3CA/CDC42/JUN/CUL2/HIF1A/PRCC/MAP2K1/ARNT/NRAS/ELOC/EGLN1/RAF1/EP300/RBX1/FH/PTPN11/RAP1A/MAP2K2/TGFB3/PIK3R3	3.67050054082408
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	18/1556	50/9376	2.16925449871465	CKB/GATM/ODC1/ALDH3A2/AMD1/OAT/LAP3/ALDH2/ALDH7A1/SAT2/CNDP2/L3HYPDH/SRM/ARG2/P4HA1/ALDH9A1/ALDH18A1/SMS	3.69771473700964
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1556	110/9376	1.75293292825426	ID3/SKP1/BAMBI/SKIL/SIN3A/ZFYVE16/SMAD4/ID1/CUL1/BMP5/SMAD7/PPP2CA/TGFBR2/FMOD/TFDP1/LEMD3/SMURF1/HDAC1/PITX2/TGIF2/SP1/TGIF1/CHRD/MYC/PPP2CB/EP300/SMAD5/RBX1/RHOA/TGFB3/ID4/CDKN2B	3.54318267183464
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1556	31/9376	2.52690936230202	HSPA5/SRP9/SRP54/SPCS3/SRPRB/SEC61B/SRP19/SRPRA/SEC61G/SPCS1/SEC11C/SPCS2/SEC11A	3.79831964815528
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	28/1556	93/9376	1.81419133703734	CDKN1B/GADD45A/PTK2/CASP3/PTEN/LAMB1/COL4A1/BIRC2/NFKB1/RB1/PIK3CA/RARB/MAX/NFKBIA/LAMA3/CKS2/LAMA2/TRAF6/CYCS/MYC/TRAF1/CDK2/IKBKB/BAX/CKS1B/TRAF4/PIK3R3/CDKN2B	3.51974203030613
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	27/1556	90/9376	1.80771208226221	IFNGR1/NFKBIE/PTEN/NFATC1/KRAS/NFKB1/PIK3CA/PPP3CC/IFNGR2/JUN/NFKBIA/STAT1/HIF1A/MAP2K1/TRAF6/NRAS/TICAM1/RAF1/CSNK2A1/IKBKB/PTPN11/MAP2K2/PPP3CA/CSNK2B/TLR4/PIK3R3/FOS	3.43439744538727
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	77/1556	333/9376	1.39333163497688	CDKN1B/MX1/PTK2/CASP3/TNFRSF1A/MAML2/PTEN/LAMB1/TBK1/SOS1/COL4A1/STAT2/HEYL/COL1A2/CTNNB1/FAS/EIF2AK2/KRAS/CCND2/NFKB1/RB1/PIK3CA/THBS3/IFNAR1/DLG3/GNAS/WNT6/HEY2/MDM2/PPP2CA/CDC42/TBPL1/HES1/CCND3/STAT1/LAMA3/HDAC1/ITGA7/LAMA2/TUBG1/MAP2K1/FZD10/HLA-F/NOTCH1/HES4/OASL/LLGL1/NRAS/CDK2/TICAM1/PARD6G/PPP2CB/TLR3/TADA3/RAF1/NOTCH2/RHEB/JAG1/EP300/CSNK1A1/PPP2R2D/ISG15/PPP2R5E/FZD3/IKBKB/HES6/BAX/CREB3L4/WNT3A/MAP2K2/FZD2/ITGA11/PPP2R5C/PSEN1/PIK3R3/DLG2/ATP6V1G1	3.25995636260007
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/1556	44/9376	2.19116616031783	GTF2B/GTF2A2/CCNH/TAF7/MNAT1/TAF9B/TAF12/TAF13/TBPL1/GTF2H2/TAF2/GTF2I/GTF2F2/TAF9/TAF15/GTF2E1	3.53263183449081
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	37/1556	137/9376	1.62738070665941	ERN1/GADD45A/CASP7/CASP3/TNFRSF1A/FAS/BIRC2/CTSC/KRAS/DDIT3/MCL1/NFKB1/EIF2S1/PIK3CA/BBC3/PMAIP1/MAP3K14/JUN/NFKBIA/NGF/MAP2K1/MAPK9/CYCS/NRAS/LMNB2/TRAF1/DAB2IP/EIF2AK3/RAF1/IKBKB/BAX/HTRA2/MAP2K2/CASP2/MAPK10/PIK3R3/FOS	3.29963587718982
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	30/1556	105/9376	1.72163055453544	STAT2/BCL10/NFATC1/KRAS/NFKB1/PLK3/PIK3CA/ARHGEF12/CYLD/MDM2/PPP3CC/CALM2/MAP3K14/JUN/NFKBIA/STAT1/RRAS/MAPK9/NRAS/EGR3/RAF1/MALT1/IKBKB/CALM1/PTPN11/CALM3/RHOA/PPP3CA/MAPK10/PIK3R3	3.31690727110736
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	26/1556	87/9376	1.80078598233017	GADD45A/CASP3/SOS1/CTNNB1/SMAD4/KRAS/PIK3CA/BBC3/PMAIP1/TGFBR2/JUN/MLH1/MAP2K1/MAPK9/CYCS/MYC/NRAS/RAF1/MSH6/BAX/MAP2K2/RHOA/TGFB3/MAPK10/PIK3R3/FOS	3.34717689598782
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/1556	62/9376	1.94377643254001	HSPA1A/HSPA1B/HSPA8/CAT/KRAS/ADCY3/PIK3CA/ADCY6/SOD2/SOD1/IRS1/SIRT1/ATG5/HDAC1/PRKAG1/NRAS/PRKAB2/ADCY9/PRKAA1/PIK3R3	3.32570646078522
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	45/1556	178/9376	1.52335287831085	CACYBP/SERPINF1/CAMK2D/SKP1/FOSL1/BAMBI/CTNNB1/SMAD4/NFATC1/CCND2/RYK/CUL1/WNT6/DAAM2/SIRT1/PPP3CC/TBL1XR1/CBY1/SIAH1/JUN/CCND3/INVS/FZD10/RUVBL1/MAPK9/MYC/PPARD/SENP2/CCAR2/EP300/CSNK1A1/RBX1/CSNK2A1/FZD3/CSNK1E/PRICKLE2/WNT3A/FZD2/RHOA/PPP3CA/PLCB3/CSNK2B/PSEN1/MAPK10/TLE1	3.14445202849969
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1556	30/9376	2.41028277634961	SDHD/SUCLA2/ACO1/IDH3A/DLD/SDHB/MDH1/SDHC/DLST/SUCLG1/PDHB/FH	3.4509685304361
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1556	101/9376	1.67049301331161	CDKN1B/CASP3/F3/COL3A1/VCAM1/AGTR1/COL4A1/COL1A2/SMAD4/NFATC1/KRAS/NFKB1/PIK3CA/TGFBR2/CDC42/JUN/STAT5B/STAT1/MAPK9/NRAS/PIM1/BAX/VEGFB/PLCB3/TGFB3/MAPK10/PIK3R3/STAT5A	3.0219344699081
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	37/1556	144/9376	1.54827192230791	ADH1B/CASP3/TNFRSF1A/TRA2A/TBK1/ADH5/CTNNB1/FAS/CXCL2/CXCL1/NFKB1/ALDH3A2/ACADVL/SIRT1/MAP3K14/ALDH2/NFKBIA/ALDH7A1/ADIPOR1/PRKAG1/TRAF6/MAPK9/CXCL3/TICAM1/ACADM/CPT1A/PRKAB2/CAMKK2/IKBKB/LPIN3/ALDH9A1/IRAK4/TLR4/PRKAA1/MAPK10/ADIPOR2/TRA2B	2.95744319598686
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	32/1556	122/9376	1.58051329596696	NFKBIE/SOS1/BCL10/NFATC1/KRAS/NFKB1/PIK3CA/PPP3CC/PPP2CA/MAP3K14/NCK2/CDC42/JUN/NFKBIA/MAP2K1/MAP3K8/MAPK9/NRAS/PPP2CB/RAF1/PPP2R2D/MALT1/PPP2R5E/IKBKB/PTPN11/MAP2K2/RHOA/PPP3CA/PPP2R5C/MAPK10/PIK3R3/FOS	2.87881924262505
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1556	122/9376	1.58051329596696	GNAI3/SSTR2/PTK2/SOCS2/SOS1/KRAS/ADCY3/PIK3CA/ADCY6/GNAS/SOCS1/IRS1/JUNB/STAT5B/GHR/STAT1/GNAI1/MAP2K1/MAPK9/NRAS/RAF1/EP300/ADCY9/CREB3L4/SOCS3/MAP2K2/PLCB3/ATF2/MAPK10/PIK3R3/STAT5A/FOS	2.87881924262505
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/1556	99/9376	1.64337462023837	CDKN1B/PTK2/SOS1/KRAS/ADCY3/RB1/PIK3CA/ADCY6/GNAS/MDM2/JUN/SP1/MAP2K1/NOTCH1/MAPK9/NRAS/RAF1/NOTCH2/JAG1/NCOA3/DLL1/ADCY9/BAX/MAP2K2/MAPK10/PIK3R3/FOS	2.87054792443005
Genetic Information Processing	Translation	hsa03010	Ribosome	52/1556	222/9376	1.41142685101554	RPL22L1/MRPL18/RPS7/MRPL32/RPL36A/MRPL42/RPS10/MRPL50/MRPL3/MRPL13/MRPL19/MRPL35/RPL37/MRPS15/MRPL44/MRPS27/MRPL47/MRPL16/RPL26/MRPL43/MRPL36/RSL24D1/MRPS23/MRPS31/MRPS30/MRPS35/MRPS22/MRPL40/MRPL14/MRPS11/MRPL17/MRPS10/RPS21/MRPL34/RPS13/MRPS14/MRPS18C/MRPS7/RPL32/MRPL39/MRPS28/RPS15A/MRPL22/RPS23/MRPL45/RPL7A/RPL27/MRPL51/RPL3/MRPL9/MRPL30/MRPS18B	2.76726482582758
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	67/1556	300/9376	1.3457412167952	HSPA1A/HSPA1B/MKNK2/DUSP1/JUND/HSPA8/GADD45A/STK3/HGF/CASP3/TNFRSF1A/MAP3K13/PDGFA/SOS1/FGF7/FAS/NFATC1/NF1/CACNA2D1/KRAS/DDIT3/GNG12/NFKB1/MAX/ELK4/LAMTOR3/ANGPT1/FGF2/PPP3CC/MAP3K14/TGFBR2/CDC42/JUN/CSF1/KITLG/RRAS/NGF/PPM1A/MAP4K3/MAP2K1/MAP3K8/EPHA2/DUSP8/MAP3K20/DUSP5/TRAF6/MAPK9/MYC/NRAS/CACNA1H/RAF1/PPM1B/MAP3K12/IKBKB/RAP1A/MAPT/VEGFB/MAP2K2/DUSP7/PPP3CA/ANGPT2/IRAK4/ATF2/TGFB3/MAPK10/NR4A1/FOS	2.7148859993024
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	35/1556	139/9376	1.51726433763015	FKBP4/HSPA1A/HSPA1B/HSP90AB1/HSP90AA1/GNAI3/HSP90B1/HSPA8/SOS1/KRAS/ADCY3/PIK3CA/ADCY6/GNAS/RARA/CALM2/JUN/GNAI1/SP1/MAP2K1/NRAS/PGR/RAF1/NCOA3/ADCY9/NCOA1/CALM1/NCOA2/CREB3L4/CALM3/MAP2K2/PLCB3/ATF2/PIK3R3/FOS	2.74057393968598
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	33/1556	130/9376	1.52960253114495	GNAI3/COL3A1/EDNRB/SOS1/COL4A1/COL1A2/KRAS/ADCY3/GNG12/NFKB1/PIK3CA/ADCY6/GNAS/GNB4/TGFBR2/JUN/NFKBIA/GNAI1/MAP2K1/MAPK9/NRAS/RAF1/GNG5/ADCY9/GNG11/CREB3L4/VEGFB/MAP2K2/PLCB3/ATF2/MAPK10/PIK3R3/FOS	2.71226326356841
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	48/1556	205/9376	1.41089723493636	CDKN1B/CASP3/GTF2B/IRF7/GTF2A2/VDAC3/EIF2AK2/KRAS/CCND2/NFKB1/RB1/PIK3CA/DDX3X/MDM2/PMAIP1/RANBP1/CDC42/TBPL1/JUN/NFKBIA/STAT5B/CCND3/SP100/YWHAQ/HDAC1/GTF2H2/HLA-F/NRAS/TRAF1/CDK2/EGR3/EP300/SNW1/IL6ST/HDAC3/JAK3/KAT2A/BAX/HNRNPK/CREB3L4/RHOA/ATF2/GTF2E1/PIK3R3/STAT5A/YWHAB/CDKN2B/MRPS18B	2.65331529528873
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	47/1556	200/9376	1.4160411311054	CASP7/CASP3/TNFRSF1A/ARF6/SEC24D/FAS/ABL1/NFKB1/ARHGEF12/WASL/NCK2/TUBB2A/CDC42/JUN/NFKBIA/SEC24A/ARF1/CASP4/CYFIP1/ARPC5L/WASF3/RAB1A/MYO1B/TRAF6/MAPK9/CYCS/ACTR2/ARPC3/CLDN12/ARPC1B/SEC24B/ACTR3/CYTH2/IKBKB/LPAR1/BAX/PTPN11/ABI1/RHOA/IRAK4/ARPC4/TLR4/MYO1E/MAPK10/BRK1/NCKAP1/FOS	2.65284344836628
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1556	56/9376	1.8292324641939	OSTC/STT3B/MOGS/MAN1A1/DAD1/DDOST/ALG5/DPM1/MAGT1/ALG2/MGAT2/B4GALT3/B4GALT1/SRD5A3/DPM2/TUSC3/STT3A	2.77619144494058
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/1556	43/9376	1.96185807377294	ADH1B/ADH5/HADHB/ALDH3A2/ACADVL/ALDH2/ALDH7A1/CYP2U1/HADH/ACSL3/GCDH/ACADM/CPT1A/ALDH9A1	2.81982169554742
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	40/1556	166/9376	1.45197757611423	GNAI3/EDNRB/PPP1CB/PDE3A/VDAC3/AGTR1/PDE5A/ATP2A2/NFATC1/ADCY3/ADCY6/PPP1CC/MEF2D/IRS1/GUCY1A2/ATP1B2/MYLK/PPP3CC/PRKG1/GUCY1B1/CALM2/TRPC6/GUCY1A1/GNAI1/VDAC1/MAP2K1/GTF2I/VDAC2/KCNJ8/RAF1/SLC25A5/ADCY9/CALM1/CREB3L4/CALM3/MAP2K2/RHOA/PPP3CA/PLCB3/ATF2	2.62076557640721
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	20/1556	70/9376	1.72163055453544	NFKBIE/TNFRSF1A/NFKB1/IRS1/NFKBIA/ADIPOR1/ACSL3/PRKAG1/MAPK9/CPT1A/PRKAB2/CAMKK2/IKBKB/PTPN11/SOCS3/CD36/STK11/PRKAA1/MAPK10/ADIPOR2	2.70314577719786
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	27/1556	103/9376	1.57955424663688	CALR/IFNGR1/GNAI3/TNFRSF1A/FAS/NFKB1/PIK3CA/GNAS/IFNGR2/PPP2CA/TGFBR2/JUN/NFKBIA/GNAI1/TRAF6/MAPK9/TICAM1/PPP2CB/PPP2R2D/IKBKB/PLCB3/IRAK4/TGFB3/TLR4/MAPK10/PIK3R3/FOS	2.63809015317762
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	38/1556	157/9376	1.45845136148544	CALR/CASP7/PTK2/CAMK2D/CASP3/ATP2A2/NFATC1/ODC1/ANO6/CD47/CEBPB/PROS1/TMEM30A/SIRT1/MERTK/CH25H/HIF1A/ADAM17/MAP2K1/UQCRFS1/DUSP8/ARNT/RAB5A/DUSP5/ABCA1/PPARD/RAB7A/CPT1A/AXL/PBX1/ARG2/XKR6/PTPN11/RAB5B/CD36/MAP2K2/DUSP7/GAS6	2.58397461914744
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	38/1556	157/9376	1.45845136148544	STK3/PPP1CB/TP53BP2/SNAI2/CTNNB1/SAV1/SMAD4/BIRC2/CCND2/RASSF1/MOB1A/YAP1/ID1/PPP1CC/DLG3/BBC3/WNT6/BMP5/SMAD7/PPP2CA/TGFBR2/CCND3/YWHAQ/FZD10/LLGL1/MYC/PARD6G/PPP2CB/PPP2R2D/WWTR1/FZD3/CSNK1E/TEAD2/WNT3A/FZD2/TGFB3/DLG2/YWHAB	2.58397461914744
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	21/1556	75/9376	1.68719794344473	GADD45A/CASP3/PTEN/FAS/CCND2/BBC3/MDM2/PMAIP1/RCHY1/SIAH1/CCND3/MDM4/CCNG1/EI24/SESN2/CYCS/CDK2/SESN1/CCNG2/RRM2B/BAX	2.66523015686569
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/1556	128/9376	1.50642673521851	PDE3A/PDE5A/HDDC2/ADCY3/PDE6D/ADCY6/PAICS/GUCY1A2/NUDT9/GUCY1B1/HPRT1/ADA/GUCY1A1/PAPSS1/GMPS/DGUOK/NME1/PRPS1/RRM2B/GART/AK6/AK3/NUDT5/ADCY9/PDE1A/PDE4B/ENPP1/CANT1/GMPR2/IMPDH2/PRUNE1/PPAT	2.57326644625308
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	34/1556	138/9376	1.4845944636936	MKNK2/PPP1CB/SOCS2/SOS1/KRAS/EIF4E/PIK3CA/PPP1CC/SORBS1/SOCS1/FLOT1/IRS1/CALM2/PRKAR1A/HK1/MAP2K1/PRKAG1/MAPK9/NRAS/SOCS4/RAF1/RHEB/PRKAB2/PHKG1/IKBKB/CALM1/RHOQ/SOCS3/CALM3/MAP2K2/EIF4E2/PRKAA1/MAPK10/PIK3R3	2.55809147518735
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1556	71/9376	1.69738223686593	SOCS2/SOS1/KRAS/CCND2/NFKB1/PIK3CA/SOCS1/STAT5B/STAT1/MAP2K1/MAPK9/NRAS/SOCS4/RAF1/SOCS3/MAP2K2/MAPK10/PIK3R3/STAT5A/FOS	2.6310489301291
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1556	32/9376	2.07133676092545	ATG101/ATG4C/PPP2CA/ATG5/WIPI1/IGBP1/GABARAPL2/PPP2CB/ATG4A/BECN1/ATG13	2.70783152119109
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	51/1556	227/9376	1.35379318935936	CALR/GNAI3/PTK2/CASP3/PDIA3/TNFRSF1A/TBK1/SOS1/CGAS/CTNNB1/FAS/NFATC1/B2M/KRAS/ADCY3/GNG12/NFKB1/RB1/PIK3CA/ADCY6/ARHGEF12/GNAS/GNB4/TAP1/MDM2/PPP3CC/CALM2/NFKBIA/GNAI1/SP1/MAP2K1/HLA-F/CYCS/MYC/NRAS/RAF1/RHEB/GNG5/ADCY9/IKBKB/BAX/CALM1/GNG11/CREB3L4/CALM3/MAP2K2/RHOA/PPP3CA/PLCB3/ATF2/PIK3R3	2.40692546166804
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	26/1556	101/9376	1.55117208378936	GNAI3/CAMK2D/EDNRB/CTNNB1/KRAS/ADCY3/ADCY6/GNAS/WNT6/CALM2/KITLG/GNAI1/MAP2K1/FZD10/NRAS/RAF1/EP300/FZD3/ADCY9/CALM1/CREB3L4/CALM3/WNT3A/MAP2K2/FZD2/PLCB3	2.48415104376343
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1556	68/9376	1.6836534099501	SOS1/KRAS/NFKB1/PIK3CA/RUNX1T1/RARA/STAT5B/MAP2K1/MYC/NRAS/PPARD/RAF1/PML/PIM1/IKBKB/PIM2/MAP2K2/PIK3R3/STAT5A	2.52376731392017
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	29/1556	117/9376	1.49355129303715	CDK2AP2/MORF4L2/BRD8/MEAF6/SS18/SMARCE1/ACTR6/PHF6/DPF2/BCL7B/SMARCA1/HDAC1/BRD7/GATAD2A/RUVBL1/MBD2/INO80D/PHF10/EPC2/EPC1/ARID1B/MTA2/CHRAC1/SMARCD1/BICRAL/ACTR8/DMAP1/RBBP7/MORF4L1	2.39623959925497
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1556	93/9376	1.55502114603201	SNAI2/CTNNB1/SMAD4/WASL/SORBS1/ACP1/YES1/TGFBR2/CDC42/KRIT1/MYL12B/SMURF1/VCL/PDCD10/WASF3/NECTIN3/EP300/CSNK2A1/NECTIN2/RAP1A/RHOA/CSNK2B/CCM2/SNAI1	2.39935156090703
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	35/1556	148/9376	1.42499826304454	GADD45A/PTEN/SOS1/FGF7/HEYL/CTNNB1/KRAS/RB1/PIK3CA/WNT6/HEY2/FGF2/HES1/JUN/SP1/MAP2K1/FZD10/NOTCH1/MYC/NRAS/PGR/RAF1/NOTCH2/JAG1/NCOA3/CSNK1A1/DLL1/FZD3/BAX/NCOA1/WNT3A/MAP2K2/FZD2/PIK3R3/FOS	2.32461629551812
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	33/1556	138/9376	1.44092992064379	CAMK2D/SKP1/CDC26/PPP1CB/ADCY3/ADCY6/PPP1CC/CDC16/CUL1/PPP3CC/CALM2/PPP2CA/YWHAQ/ANAPC10/CDC27/MAP2K1/SMC3/CDK2/PPP2CB/PGR/RBX1/AR/PPP2R5E/ADCY9/SLK/CALM1/MAD2L2/ANAPC16/CALM3/PPP3CA/PPP2R5C/ANAPC13/YWHAB	2.32759380401647
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1556	253/9376	1.30993629149436	PPID/CALCOCO2/PTK2/TNFRSF1A/SKP1/MAP1LC3B/RIPK2/TBK1/UBE2N/ARF6/CGAS/BCL10/NFKB1/PIK3CA/UBE2D1/WASL/CUL1/MDM2/CDC42/JUN/NFKBIA/MYL12B/ATG5/WIPI1/VCL/ARF1/UBE2V2/CASP4/HK1/ARPC5L/VDAC1/TIFA/TRAF6/MAPK9/CYCS/ACTR2/ARPC3/ARPC1B/BNIP3/RBX1/UBE2D2/RRAGC/MALT1/ACTR3/CYTH2/IKBKB/BAX/UBB/RHOA/PLCB3/ARPC4/TLR4/BECN1/MAPK10/PIK3R3	2.22920964479902
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1556	48/9376	1.75749785775493	HIBCH/HADHB/ALDH3A2/HMGCS1/HIBADH/DLD/ALDH2/ALDH7A1/IVD/HADH/ACADM/ALDH9A1/OXCT1/HSD17B10	2.34690125360092
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	26/1556	106/9376	1.47800358927099	CDKN1B/HSP90AB1/HSP90AA1/HSP90B1/PTEN/PDGFA/SOS1/CTNNB1/KRAS/NFKB1/RB1/PIK3CA/PLAU/PLAT/MDM2/NFKBIA/MAP2K1/NRAS/CDK2/RAF1/EP300/AR/IKBKB/CREB3L4/MAP2K2/PIK3R3	2.20765538634978
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/1556	44/9376	1.78032250525824	DYNLL1/ADCY3/ADCY6/GNAS/DYNC2LI1/DCTN4/DCTN6/NSF/RAB5A/DYNC1LI2/ADCY9/RAB5B/CREB3L4	2.31419613407197
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1556	31/9376	1.94377643254001	CAT/ACO1/GCSH/DLD/MDH1/ACSS2/PGP/AFMID/GRHPR/SHMT2	2.34772584128905
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/1556	63/9376	1.6259844126168	ALDH3A2/DLD/SETD2/ALDH2/KMT5A/PLOD2/ALDH7A1/DLST/HADH/GCDH/NSD1/EZH2/SETD7/PLOD1/ALDH9A1/PHYKPL/SMYD3	2.22369925413841
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	17/1556	63/9376	1.6259844126168	CCNH/POLR2K/MNAT1/RAD23B/POLR2M/POLR2C/GTF2H2/ERCC4/POLR2J/RBX1/RFC5/CUL4B/PCNA/RFC1/RPA3/ERCC6/ERCC1	2.22369925413841
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	29/1556	122/9376	1.43234017447006	MED30/SIN3A/CTNNB1/ATP2A2/KRAS/PIK3CA/ATP1B2/MDM2/STAT1/HIF1A/HDAC1/MAP2K1/NOTCH1/MYC/NRAS/RAF1/NOTCH2/RHEB/NCOA3/EP300/HDAC3/SLC16A2/KAT2A/PFKM/NCOA1/NCOA2/MAP2K2/PLCB3/PIK3R3	2.14401499891763
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1556	158/9376	1.37294588526244	TNFRSF1A/PTEN/SOS1/RNF152/SEC13/KRAS/EIF4E/PIK3CA/IRS1/WNT6/LAMTOR3/MAP2K1/SESN2/FZD10/NRAS/RAF1/RHEB/MAPKAP1/RRAGC/STRADB/FZD3/IKBKB/LPIN3/DDIT4/LAMTOR2/WNT3A/STK11/MAP2K2/FZD2/RHOA/RICTOR/LAMTOR5/EIF4E2/PRKAA1/PIK3R3/ATP6V1G1	2.10883727543023
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/1556	78/9376	1.54505306176257	GNAI3/CASP7/CASP3/C1S/NFKB1/CALM2/C1R/JUN/GNAI1/TRAF6/MAPK9/TICAM1/CALM1/CFL2/CALM3/RHOA/IRAK4/TLR4/MAPK10/FOS	2.15614702732214
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	32/1556	138/9376	1.39726537759398	PTK2/TBK1/ARF6/ARHGEF7/NFATC1/NFKB1/PIK3CA/ARHGEF12/WASL/CDC42/JUN/NFKBIA/ARPC5L/MAP2K1/PKN2/TRAF6/MAPK9/TICAM1/ACTR2/ARPC3/ARPC1B/ACTR3/IKBKB/PIP5K1A/MAP2K2/RHOA/IRAK4/ARPC4/TLR4/MAPK10/PIK3R3/FOS	2.0970961328456
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/1556	93/9376	1.49022859828068	IFNGR1/NFKBIE/MAML2/NFATC1/NFKB1/PPP3CC/IFNGR2/JUN/NFKBIA/STAT5B/STAT1/NOTCH1/MAPK9/NOTCH2/STAT6/JAG1/JAK3/DLL1/IKBKB/PPP3CA/MAPK10/STAT5A/FOS	2.11925394355726
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	29/1556	125/9376	1.39796401028278	GNAI3/TNFRSF1A/PTEN/ORMDL1/KRAS/DEGS1/NFKB1/PIK3CA/CERS6/PPP2CA/GNAI1/MAP2K1/MAPK9/NRAS/SPTSSA/CERS2/PPP2CB/S1PR3/RAF1/PPP2R2D/PPP2R5E/ORMDL3/BAX/MAP2K2/RHOA/PLCB3/PPP2R5C/MAPK10/PIK3R3	1.99798177601807
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1556	110/9376	1.42425800420659	CDKN1B/MKNK2/IFNGR1/CAMK2D/EIF4E/NFKB1/PIK3CA/ANGPT1/IFNGR2/CUL2/HIF1A/HK1/MAP2K1/PDHB/ARNT/ELOC/EGLN1/EP300/RBX1/PFKM/LDHB/MAP2K2/ANGPT2/EIF4E2/TLR4/PIK3R3	1.99649072644131
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	37/1556	168/9376	1.32709021912107	PPID/HSP90AB1/IFNGR1/HSP90AA1/SPATA2L/CAMK2D/TNFRSF1A/CHMP5/VDAC3/STAT2/FAS/BIRC2/EIF2AK2/IFNAR1/DNM1L/CYLD/GLUD1/IFNGR2/STAT5B/STAT1/VDAC1/CHMP1B/VDAC2/MAPK9/TICAM1/TLR3/CHMP2B/STAT6/JAK3/SLC25A5/SPATA2/BAX/CHMP4A/TLR4/MAPK10/STAT5A/MLKL	1.90821190624842
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	50/1556	238/9376	1.26590481951135	OAS1/ACE2/MX1/RPL22L1/OAS2/C7/RPS7/TNFRSF1A/RPL36A/RPS10/TBK1/AGTR1/STAT2/CGAS/EIF2AK2/RPL37/C1S/NFKB1/PIK3CA/IFNAR1/NRP1/ADAR/C1R/RPL26/JUN/RSL24D1/NFKBIA/STAT1/ADAM17/TRAF6/MAPK9/OAS3/RPS21/RPS13/TLR3/CFD/IL6ST/ISG15/RPL32/RPS15A/IKBKB/RPS23/IRAK4/RPL7A/RPL27/TLR4/MAPK10/PIK3R3/RPL3/FOS	1.85342991597601
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1556	107/9376	1.40787545347524	CAMK2D/GNAS/PPP4R3B/SIRT1/PPP3CC/CALM2/PRKAG1/PDHB/SIK2/SIK1/CPT1A/EP300/PRKAB2/PHKG1/PPP4C/PFKM/PPP4R3A/CALM1/LDHB/CREB3L4/CALM3/PPP3CA/PLCB3/ATF2/PRKAA1	1.89273614330526
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	23/1556	97/9376	1.42877587257838	GNAI3/CAMK2D/RASD1/ADCY3/GNG12/ADCY6/GNAS/GNB4/GUCY1A2/PRKG1/GUCY1B1/CALM2/GUCY1A1/GNAI1/CACNA1H/NOS1AP/GNG5/ADCY9/CALM1/GNG11/CALM3/PLCB3/FOS	1.89344492478934
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1556	34/9376	1.77226674731589	NFIL3/SKP1/CUL1/FBXL3/BHLHE40/PRKAG1/RBX1/PRKAB2/CSNK1E/PRKAA1	2.01221285979602
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/1556	170/9376	1.31147739301376	MPDZ/HSPA4/JAM3/RAB8A/RAB13/RAP2C/DLG3/PPP2CA/NEDD4/CDC42/JUN/MYL12B/RAB8B/ARPC5L/MSN/YBX3/WHAMM/PRKAG1/LLGL1/MAPK9/ACTR2/ARPC3/PARD6G/PPP2CB/CLDN12/PPP2R2D/ARPC1B/PRKAB2/ACTR3/PCNA/RAP1A/STK11/RHOA/ARPC4/PRKAA1/MAPK10/DLG2	1.82811101112089
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1556	13/9376	2.31757959264386	XRCC4/RAD50/LIG4/MRE11/XRCC5	2.1204502236071
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1556	44/9376	1.64337462023837	OSTC/STT3B/MAN1A1/DAD1/DDOST/MAGT1/ALG2/MGAT2/B4GALT3/B4GALT1/TUSC3/STT3A	1.90805090059902
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1556	140/9376	1.33426367976496	KLF2/GNAI3/MAP1LC3B/AGTR1/SMAD4/KRAS/ADCY3/GNG12/ADCY6/MEF2D/GNB4/MYLK/PLAT/CALM2/RRAS/GNAI1/MAP2K1/PRKAG1/NRAS/RAF1/JAG1/PRKAB2/GNG5/ADCY9/CALM1/GNG11/CALM3/MAP2K2/PLCB3/BECN1/PRKAA1	1.77745372747766
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/1556	109/9376	1.38204287634726	HSP90AB1/IFNGR1/HSP90AA1/NFKBIE/SMAD4/NFATC1/NFKB1/PPP3CC/IFNGR2/RARA/TGFBR2/JUN/NFKBIA/STAT5B/STAT1/HIF1A/MAPK9/STAT6/IL6ST/JAK3/IKBKB/PPP3CA/MAPK10/STAT5A/FOS	1.78954585686259
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1556	94/9376	1.41027183722584	HSP90AB1/HSP90AA1/JUND/HSP90B1/CASP3/FOSL1/TBK1/CXCL2/SRSF1/CXCL1/NFKB1/CEBPB/JUN/NFKBIA/TRAF6/MAPK9/ELAVL1/CXCL3/IKBKB/TRAF4/MAPK10/FOS	1.78320761036584
Organismal Systems	Endocrine system	hsa04924	Renin secretion	17/1556	69/9376	1.4845944636936	GNAI3/PDE3A/AGTR1/ADCY6/GNAS/GUCY1A2/PPP3CC/GUCY1B1/CALM2/GUCY1A1/GNAI1/REN/PDE1A/CALM1/CALM3/PPP3CA/PLCB3	1.80212617484653
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	24/1556	105/9376	1.37730444362835	GADD45A/TNFRSF1A/VCAM1/BCL10/CXCL2/BIRC2/CXCL1/NFKB1/PLAU/CYLD/MAP3K14/UBE2I/NFKBIA/TRAF6/EDA/CXCL3/TRAF1/TICAM1/CSNK2A1/MALT1/IKBKB/IRAK4/CSNK2B/TLR4	1.7342445447001
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	49/1556	238/9376	1.24058672312112	HGF/TBK1/PDGFA/SOS1/ARF6/FGF7/SHOC2/NF1/KRAS/RASSF1/ABL1/GNG12/NFKB1/PIK3CA/RASA3/GNB4/EXOC2/ANGPT1/FGF2/ETS2/CALM2/CDC42/CSF1/KITLG/RRAS/NGF/MAP2K1/EPHA2/RAB5A/MAPK9/NRAS/PLA2G2A/SYNGAP1/RAF1/GNG5/IKBKB/CALM1/PTPN11/GNG11/RAB5B/RAP1A/VEGFB/CALM3/MAP2K2/RHOA/ANGPT2/RGL2/MAPK10/PIK3R3	1.67695580260174
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	31/1556	142/9376	1.31547123357109	IFNGR1/JUND/TNFRSF1A/FOSL1/STAT2/ATP2A2/NFATC1/NFKB1/PIK3CA/IFNAR1/SOCS1/CYLD/JUNB/PPP3CC/IFNGR2/MAP3K14/TGFBR2/JUN/CSF1/NFKBIA/STAT1/MAP2K1/TRAF6/MAPK9/FHL2/IKBKB/SOCS3/PPP3CA/MAPK10/PIK3R3/FOS	1.68964730156775
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/1556	60/9376	1.50642673521851	GNAI3/KRAS/GNAS/GUCY1A2/PRKG1/GUCY1B1/PPP2CA/GUCY1A1/GNAI1/MAP2K1/NRAS/PPP2CB/RAF1/MAP2K2/PLCB3	1.75535341330522
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1556	116/9376	1.35058948674763	SDHD/CAT/HIBCH/RPE/ADH5/SUCLA2/ACO1/IDH3A/GCSH/DLD/SDHB/GLUD1/MDH1/ACSS2/SDHC/DLST/HK1/SUCLG1/PDHB/PRPS1/PGP/ESD/FH/PFKM/RPIA/SHMT2	1.69476484949805
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/1556	138/9376	1.30993629149436	SDHD/NDUFA5/NDUFC2/NDUFB3/SDHB/SDHC/ATP5F1C/NDUFB6/NDUFA12/NDUFV2/NDUFA7/NDUFB8/UQCRFS1/COX11/UQCRH/UQCRC2/CYCS/NDUFA6/NDUFB5/ATP5MC3/ATP5MC1/NDUFA8/NDUFS3/PPA1/COX7A2L/NDUFA2/NDUFA4/NDUFS4/COX7B/ATP6V1G1	1.63610079050385
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1556	154/9376	1.29122291590158	GNAI3/CAMK2D/PPP1CB/NFATC1/CACNA2D1/KRAS/ADCY3/ADCY6/PPP1CC/GNAS/GUCY1A2/MYLK/PPP3CC/GUCY1B1/CALM2/JUN/GUCY1A1/GNAI1/MAP2K1/PRKAG1/NRAS/RAF1/PRKAB2/CAMKK2/ADCY9/CALM1/CALM3/MAP2K2/RHOA/PPP3CA/PLCB3/PRKAA1/FOS	1.62540056152119
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/1556	112/9376	1.34502387073081	HSPA1A/HSPA1B/IFNGR1/GNAI3/HSPA8/CASP3/TNFRSF1A/LAMB1/BIRC2/NFKB1/SOCS1/IFNGR2/NFKBIA/STAT1/LAMA3/GNAI1/LAMA2/TRAF6/MAPK9/CYCS/IKBKB/IRAK4/TGFB3/TLR4/MAPK10	1.63849808915453
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/1556	76/9376	1.42714111757543	GADD45A/CAMK2D/PTEN/PDGFA/SOS1/KRAS/RB1/PIK3CA/MDM2/CALM2/MAP2K1/NRAS/RAF1/BAX/CALM1/CALM3/MAP2K2/PIK3R3	1.66772239022187
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1556	23/9376	1.8339108080921	IDI1/HMGCS1/ZMPSTE24/FNTA/PMVK/DHDDS/ICMT	1.78605616386004
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1556	23/9376	1.8339108080921	MLH1/MSH6/RFC5/PCNA/PMS2/RFC1/RPA3	1.78605616386004
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1556	23/9376	1.8339108080921	ACE2/AGTR1/ENPEP/LNPEP/REN/ATP6AP2/PREP	1.78605616386004
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1556	37/9376	1.62856944347947	GADD45A/TFG/CTNNB1/KRAS/MAP2K1/MYC/NRAS/BAX/MAP2K2/CCDC6	1.70879906317694
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/1556	42/9376	1.57816134165749	CAT/ALDH3A2/INMT/DLD/ALDH2/ALDH7A1/DLST/HADH/GCDH/AFMID/ALDH9A1	1.67504644870023
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/1556	77/9376	1.40860681734718	GADD45A/SMAD4/KRAS/NFKB1/RB1/PIK3CA/TGFBR2/CDC42/STAT1/MAP2K1/MAPK9/RAF1/IKBKB/BAX/TGFB3/MAPK10/PIK3R3/ARHGEF6	1.60590520237196
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	23/1556	103/9376	1.34554621009809	PTK2/CASP3/COL3A1/LAMB1/COL4A1/COL1A2/CXCL2/CXCL1/NFKB1/PIK3CA/GNAS/LAMA3/VCL/LAMA2/RAB5A/CXCL3/RAB7A/ARG2/RAB5B/PLCB3/TGFB3/TLR4/PIK3R3	1.57290203568943
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1556	67/9376	1.43897479185052	CAMK2D/PPP1CB/KRAS/PPP1CC/PPP3CC/CALM2/MAP2K1/NRAS/RAF1/EP300/CALM1/RAP1A/CALM3/MAP2K2/PPP3CA/PLCB3	1.60846837261772
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1556	28/9376	1.72163055453544	CBR1/MOCS2/PCBD1/DHFR/PTS/MOCS1/GCH1/QDPR	1.70577456842378
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	38/1556	184/9376	1.24443947691964	GNAI3/TRPC4/PTK2/CAMK2D/KRAS/ABL1/PIK3CA/ARHGEF12/NRP1/RYK/PPP3CC/EPHA3/ENAH/NCK2/TRPC6/CDC42/SEMA4B/MYL12B/TRPC1/RRAS/GNAI1/EPHB6/EPHA2/NRAS/SLIT3/UNC5C/PARD6G/RAF1/ROBO1/FZD3/PTPN11/CFL2/CDK5/RHOA/PPP3CA/NTN4/PIK3R3/SEMA6D	1.49369630736017
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	19/1556	83/9376	1.37937869730851	CASP7/CASP3/IRF7/TBK1/POLR2K/CGAS/NFKB1/ADAR/NFKBIA/POLR1D/POLR3K/G3BP1/IKBKB/ZCCHC3/POLR3H/IFI16/SAMHD1/POLR3GL/MLKL	1.54853518120464
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/1556	73/9376	1.40324682184738	GADD45A/HGF/SOS1/KRAS/RASSF1/RB1/PIK3CA/RARB/STAT5B/MAP2K1/NRAS/RAF1/JAK3/BAX/MAP2K2/PIK3R3/STAT5A	1.54279396304047
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	41/1556	201/9376	1.22912430137232	CDKN1B/GADD45A/DDX5/PTK2/PDGFA/NFKBIZ/SIN3A/BIRC2/MLF1/CCND2/DDIT3/NFKB1/HOXA11/PLAU/SS18/CEBPB/MAX/RUNX1T1/CDK14/ELK4/HOXA10/PLAT/MDM2/RARA/CCNT2/TGFBR2/HDAC1/MEIS1/PRCC/SP1/ATF1/MYC/TRAF1/ETV7/MLLT3/PBX1/PML/CDK9/BAX/TAF15/ETV6	1.46471525244923
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1556	89/9376	1.35409144738742	GNAI3/PDGFA/SOS1/KRAS/ADCY3/ADCY6/GNAS/GUCY1A2/PRKG1/GUCY1B1/TUBB2A/GUCY1A1/GNAI1/MAP2K1/NRAS/RAF1/ADCY9/LPAR1/MAP2K2/PLCB3	1.49713090535494
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1556	142/9376	1.27303667764944	KLF2/HSP90AB1/HSP90AA1/DUSP1/HSP90B1/GSTM3/SUMO1/PTK2/TNFRSF1A/VCAM1/PDGFA/CTNNB1/NFKB1/PIK3CA/SUMO2/PLAT/CALM2/JUN/MAPK9/SDC4/TXN/IKBKB/CALM1/CALM3/RHOA/CAV2/PRKAA1/MAPK10/PIK3R3/FOS	1.46237005636663
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/1556	29/9376	1.66226398368939	STK3/SAV1/RASSF1/MOB1A/YAP1/WWTR1/CSNK1E/TEAD2	1.59323952852522
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1556	59/9376	1.42982876563113	GADD45A/PTEN/SOS1/CTNNB1/KRAS/PIK3CA/MLH1/MAP2K1/MYC/NRAS/RAF1/BAX/MAP2K2/PIK3R3	1.47730610544765
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1556	122/9376	1.28416705297316	RAB8A/PIK3CA/IRS1/SIRT1/RAB10/TBC1D1/PPP2CA/ADIPOR1/PRKAG1/ELAVL1/PPP2CB/CPT1A/RHEB/PPP2R2D/PRKAB2/STRADB/PPP2R5E/CAMKK2/PFKM/CREB3L4/CD36/STK11/PPP2R5C/PRKAA1/ADIPOR2/PIK3R3	1.40921075521022
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1556	80/9376	1.35578406169666	HGF/PTEN/PDGFA/SOS1/NF1/KRAS/EIF4E/PIK3CA/FGF2/MAP2K1/NRAS/AXL/RAF1/BAX/MAP2K2/EIF4E2/GAS6/PIK3R3	1.42551070412599
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	41/1556	204/9376	1.21104894399919	DDX5/PTK2/HGF/CAMK2D/CASP3/PPP1CB/SOS1/COL1A2/CTNNB1/FAS/KRAS/HOXD10/PIK3CA/PPP1CC/PLAU/ARHGEF12/WNT6/FGF2/MDM2/TWIST1/CDC42/RRAS/HIF1A/MSN/MAP2K1/FZD10/MYC/NRAS/RAF1/SDC4/FZD3/PTPN11/WNT3A/MAP2K2/FZD2/FRS2/RHOA/CAV2/HSPB2/TLR4/PIK3R3	1.35941889538075
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	46/1556	232/9376	1.19475223827675	TMSB4X/C7/PTK2/PPP1CB/PDGFA/SOS1/FGF7/ARHGEF7/KRAS/GNG12/PIK3CA/PPP1CC/ARHGEF12/WASL/MYLK/FGF2/ENAH/CDC42/MYL12B/RRAS/VCL/CYFIP1/ARPC5L/ITGA7/MSN/MAP2K1/ITGAE/NRAS/ACTR2/ARPC3/RAF1/PIP4K2A/ARPC1B/ACTR3/LPAR1/CFL2/PIP5K1A/MAP2K2/RHOA/ITGA11/ABI2/ARPC4/PIK3R3/BRK1/NCKAP1/ARHGEF6	1.33981673930087
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	19/1556	86/9376	1.3312608357745	CDKN1B/PTK2/CAMK2D/SOS1/KRAS/ABL1/PIK3CA/NCK2/JUN/STAT5B/MAP2K1/MAPK9/MYC/NRAS/RAF1/MAP2K2/MAPK10/PIK3R3/STAT5A	1.37657069499621
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	69/1556	362/9376	1.14854635060859	CDKN1B/HSP90AB1/HSP90AA1/HSP90B1/PTK2/HGF/PTEN/LAMB1/PDGFA/SOS1/COL4A1/FGF7/COL1A2/KRAS/CCND2/EIF4E/MCL1/GNG12/NFKB1/PIK3CA/THBS3/IFNAR1/GNB4/IRS1/ANGPT1/FGF2/MDM2/PPP2CA/CSF1/GHR/CCND3/YWHAQ/LAMA3/KITLG/ITGA7/LAMA2/NGF/MAP2K1/EPHA2/PKN2/MYC/NRAS/CDK2/PPP2CB/RAF1/RHEB/PPP2R2D/JAK3/LPAR6/PPP2R5E/GNG5/IKBKB/LPAR1/DDIT4/GNG11/CREB3L4/VEGFB/STK11/MAP2K2/ITGA11/ANGPT2/ATF2/PPP2R5C/EIF4E2/TLR4/PRKAA1/PIK3R3/YWHAB/NR4A1	1.28571453372278
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	43/1556	217/9376	1.19403409427458	HSP90AB1/PTGES3/HSP90AA1/GNAI3/HSP90B1/GSTM3/KLF4/SOS1/FGF7/KRAS/ADCY3/NFKB1/RB1/PIK3CA/ADCY6/GNAS/KPNA1/FGF2/JUN/STAT5B/CCND3/GNAI1/KPNA4/MAP2K1/ARNT/MYC/NRAS/KPNA3/PGR/RAF1/NOTCH2/JAG1/DLL1/AR/ADCY9/CREB3L4/EPHX1/MAP2K2/ATF2/PIK3R3/STAT5A/KPNA2/FOS	1.28994425648271
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1556	71/9376	1.35790578949274	JAM3/CASP3/CXCL2/CXCL1/NFKB1/MAP3K14/CDC42/JUN/NFKBIA/ADAM17/MAPK9/CXCL3/IKBKB/PTPN11/MAPK10/ATP6V1G1	1.3502891165737
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/1556	71/9376	1.35790578949274	PTEN/KRAS/PIK3CA/GLS/HIF1A/HK1/MAP2K1/PDHB/MYC/NRAS/RAF1/SLC1A5/PFKM/LDHB/MAP2K2/PIK3R3	1.3502891165737
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1556	21/9376	1.72163055453544	ALDH3A2/AASDHPPT/ALDH2/CSAD/PANK3/ENPP1	1.47669132243189
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1556	98/9376	1.29122291590158	PTEN/IPMK/PIK3CA/PIK3C2A/CALM2/INPP4B/PIP4P2/IMPA1/PIP4K2A/MTMR2/INPP1/CALM1/OCRL/PIP5K1A/CALM3/PLCB3/INPP5E/PIK3R3/MTMR4/PI4KB/IMPA2	1.29270211014258
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1556	56/9376	1.39882482556004	CCND2/CUL1/EFCAB7/SMURF1/SPOP/CUL3/SPOPL/CSNK1G3/EVC/CSNK1A1/CSNK1E/MOSMO/EVC2	1.33522759486513
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1556	109/9376	1.27147944623948	TNFRSF1A/PPP1CB/PTEN/MLX/GFPT1/NFKB1/PIK3CA/PPP1CC/IRS1/NFKBIA/PRKAG1/MAPK9/CPT1A/PRKAB2/IKBKB/PTPN11/CREB3L4/SOCS3/CD36/TRIB3/PRKAA1/MAPK10/PIK3R3	1.27165024744399
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/1556	31/9376	1.55502114603201	AOC3/HIBCH/ALDH3A2/ALDH2/ALDH7A1/CSAD/CNDP2/ALDH9A1	1.38066330337823
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	36/1556	181/9376	1.19848314846113	HSPD1/IFNGR1/CAMK2D/CASP3/TNFRSF1A/NFYB/RIPK2/HSPA9/BCL10/NFKB1/PLK3/CEBPB/ARHGEF12/LAMP2/PPP3CC/IFNGR2/CALM2/STAT1/RAB5A/TRAF6/MAPK9/CYCS/RAB7A/RAF1/EP300/MALT1/BAX/CALM1/RAB5B/CALM3/RHOA/PPP3CA/IRAK4/TGFB3/TLR4/MAPK10	1.20274654772048
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1556	110/9376	1.25992054218275	HSP90AB1/HSP90AA1/GNAI3/CDC26/KRAS/ADCY3/PIK3CA/ADCY6/CDC16/ANAPC10/GNAI1/CDC27/MAP2K1/MAPK9/CDK2/PGR/RAF1/ADCY9/MAD2L2/ANAPC16/ANAPC13/MAPK10/PIK3R3	1.22314475374464
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/1556	78/9376	1.31329510249819	PTEN/IPMK/PIK3CA/MINPP1/PIK3C2A/INPP4B/IMPA1/PIP4K2A/MTMR2/INPP1/OCRL/PIP5K1A/PLCB3/INPP5E/MTMR4/PI4KB/IMPA2	1.23934778339124
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/1556	78/9376	1.31329510249819	PTK2/CTNNB1/PIK3CA/WASL/CDC42/VCL/ARPC5L/ACTR2/ARPC3/ARPC1B/ACTR3/CLTA/MAD2L2/RHOA/CAV2/ARPC4/PIK3R3	1.23934778339124
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1556	73/9376	1.32070289115047	GADD45A/HGF/PTEN/PDGFA/FGF7/KRAS/RB1/PIK3CA/FGF2/MDM2/MAP2K1/NRAS/RAF1/BAX/MAP2K2/PIK3R3	1.22698669298835
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/1556	22/9376	1.64337462023837	HNMT/ALDH3A2/ALDH2/ALDH7A1/CNDP2/ALDH9A1	1.34760818633178
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1556	47/9376	1.41027183722584	SOCS2/PIK3CA/SOCS1/IRS1/HK1/MAPK9/SOCS4/IKBKB/SOCS3/MAPK10/PIK3R3	1.25773789628372
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	31/1556	155/9376	1.20514138817481	CDKN1B/GNAI3/CAMK2D/RASD1/AGTR1/CTNNB1/ADCY3/RB1/ADCY6/GNAS/WNT6/GNAI1/SP1/MAP2K1/FZD10/ARNT/CDK2/CACNA1H/PBX1/FH/FZD3/ADCY9/RAP1A/CREB3L4/WNT3A/MAP2K2/FZD2/PLCB3/ATF2/CDKN2B/NR4A1	1.14872794462345
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/1556	133/9376	1.22326381506465	GNAI3/CAMK2D/PPP1CB/GNG12/PPP1CC/GNAS/GNB4/PPP3CC/CALM2/PPP2CA/GNAI1/MAPK9/PPP2CB/PPP2R2D/PPP2R5E/GNG5/COMT/CALM1/GNG11/CREB3L4/CALM3/PPP3CA/PLCB3/ATF2/PPP2R5C/MAPK10/FOS	1.15671067480158
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/1556	144/9376	1.21351042559269	ID3/KLF4/TBX3/SKIL/CTNNB1/SMAD4/KRAS/ID1/PIK3CA/WNT6/PCGF5/FGF2/MEIS1/MAP2K1/FZD10/MYC/NRAS/RAF1/SMAD5/IL6ST/JAK3/PCGF2/FZD3/LIF/WNT3A/MAP2K2/FZD2/PIK3R3/ID4	1.15170033289929
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/1556	250/9376	1.15693573264781	LAPTM4B/AP1G1/CD164/CTSC/AP3M1/CLN5/VPS29/VPS13C/AP3S1/LAPTM4A/DTNBP1/VPS26A/LAMP2/LAMTOR3/SCARB2/OSTM1/OSBP/CLN8/ARL8B/PPT1/NCOA7/SLC36A4/M6PR/RAB7A/BLOC1S4/TLR3/ARSG/NEU1/ARL8A/STX17/RRAGC/BLOC1S2/CLTA/IDS/AP3M2/GNPTG/CTBS/LAMTOR2/SNAPIN/AP1S2/PLEKHM1/LAMTOR5/OSBPL2/DMXL1/SORT1/ROGDI/SLC2A6/ATP6V1G1	1.12186001508178
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	30/1556	150/9376	1.20514138817481	CDKN1B/GADD45A/HGF/SOS1/FGF7/CTNNB1/SMAD4/KRAS/RB1/PIK3CA/RARB/WNT6/FGF2/TGFBR2/MLH1/MAP2K1/FZD10/MYC/NRAS/CDK2/RAF1/CSNK1A1/FZD3/BAX/WNT3A/MAP2K2/FZD2/TGFB3/PIK3R3/CDKN2B	1.12974194212765
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	41/1556	212/9376	1.16534898384828	GNAI3/HGF/PDGFA/FGF7/CTNNB1/KRAS/ADCY3/ID1/PIK3CA/ADCY6/GNAS/PRKD3/ANGPT1/FGF2/ENAH/CALM2/CDC42/KRIT1/CSF1/KITLG/RRAS/GNAI1/NGF/MAP2K1/EPHA2/NRAS/PARD6G/RAF1/ADCY9/LPAR1/SIPA1/CALM1/RAP1A/VEGFB/CALM3/MAP2K2/RHOA/PLCB3/ANGPT2/PIK3R3/CNR1	1.08621045463498
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/1556	69/9376	1.30993629149436	CAMK2D/PPP1CB/PPP1CC/GNAS/SIRT1/PPP3CC/CALM2/JUN/HDAC1/CALM1/CREB3L4/CALM3/PPP3CA/ATF2/FOS	1.15260149523705
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1556	91/9376	1.25811463600667	NFKBIE/SOS1/BCL10/NFATC1/KRAS/NFKB1/PIK3CA/PPP3CC/JUN/NFKBIA/MAP2K1/NRAS/RAF1/MALT1/IKBKB/MAP2K2/PPP3CA/PIK3R3/FOS	1.10364507954423
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1556	33/9376	1.46077744021189	SEC22B/BET1/STX5/VAMP5/VTI1A/GOSR1/STX17/BNIP1	1.18274756135416
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1556	44/9376	1.36947885019864	MBD4/PARG/TDG/APTX/NEIL2/MUTYH/RFC5/APEX1/PCNA/RFC1	1.09576043365312
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/1556	109/9376	1.21619773118559	IRF7/TBK1/STAT2/NFKB1/PIK3CA/IFNAR1/JUN/NFKBIA/STAT1/MAP2K1/MAP3K8/TRAF6/MAPK9/TICAM1/TLR3/IKBKB/MAP2K2/IRAK4/TLR4/MAPK10/PIK3R3/FOS	1.0127024427347
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1556	39/9376	1.39054775558632	ALDH1L2/MTHFD2/DHFR/GCSH/DLD/MAT2A/ALDH7A1/GART/SHMT2	1.09015895959264
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1556	34/9376	1.41781339785271	POLR2K/POLR2M/POLR2C/POLR1D/POLR2J/POLR3K/POLR3H/POLR3GL	1.0886516803635
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1556	14/9376	1.72163055453544	B4GALT3/B4GALT1/ST3GAL2/B4GALT4	1.20526257350166
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	19/1556	93/9376	1.23105840727534	CAMK2D/SOS1/KRAS/ADCY3/ADCY6/GNAS/CALM2/CDC42/JUN/MAP2K1/MAPK9/NRAS/RAF1/ADCY9/CALM1/CALM3/MAP2K2/PLCB3/MAPK10	0.99886347415817
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1556	72/9376	1.25535561268209	SIKE1/IRF7/TBK1/TANK/NFKB1/DDX3X/CYLD/ADAR/NFKBIA/ATG5/TRAF6/MAPK9/ISG15/IKBKB/MAPK10	0.970205792904377
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1556	83/9376	1.23418093969709	CAT/SCP2/HSD17B4/FAR1/PEX6/SOD2/SOD1/MPV17/ACSL3/PEX13/ECH1/GNPAT/NUDT12/PEX19/AGPS/PEX2/PMVK	0.955871867506595
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1556	67/9376	1.2591029428692	ADH1B/ADH5/ALDH3A2/MINPP1/DLD/ACSS2/ALDH2/ALDH7A1/HK1/PDHB/ALDH9A1/PFKM/LDHB/AKR1A1	0.949391392385932
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1556	51/9376	1.29966228136499	PDIA4/KDELR2/KDELR3/SEC61B/ADCY3/GNAS/ARF1/SEC61G/ADCY9/KDELR1/ATP6V1G1	0.957149567279027
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1556	30/9376	1.40599828620394	PIGK/PIGP/PIGF/PIGA/PGAP1/DPM2/PIGH	0.993479699672273
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1556	10/9376	1.80771208226221	PAPSS1/BPNT1/SELENBP1	1.13989949341323
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1556	57/9376	1.26856988228927	SCP2/HSD17B4/HADHB/ACADVL/PPT1/HADH/ACSL3/CBR4/ACADM/CPT1A/ELOVL5/HSD17B12	0.907187669773657
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1556	41/9376	1.32271615775284	KRAS/RASSF1/RB1/MDM2/MAP2K1/MYC/NRAS/RAF1/MAP2K2	0.923724654894971
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1556	52/9376	1.27466877595412	VDAC3/VAPA/MYLIP/STARD3NL/VDAC1/ABCA1/VDAC2/APOE/VAPB/CD36/SORT1	0.8859248617771
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1556	42/9376	1.29122291590158	MAP1LC3B/SLC39A14/VDAC3/PRNP/ATG5/SAT2/ACSL3/VDAC2/LPCAT3	0.843729727177187
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1556	75/9376	1.20514138817481	GSTM3/CASP3/TOP2B/FAS/BIRC2/PIK3CA/BBC3/MDM2/PMAIP1/MLH1/CYCS/MSH6/BAX/PIK3R3/ERCC1	0.795620853351347
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1556	21/9376	1.43469212877953	DSE/CHST7/CHSY1/CHSY3/CHST11	0.889521778788065
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	28/1556	149/9376	1.13234761305015	AVPR1A/PDGFA/SOS1/ARF6/AGTR1/KRAS/ADCY3/PIK3CA/ADCY6/GNAS/KITLG/RRAS/ARF1/MAP2K1/NRAS/RAF1/AGPAT5/RHEB/LPAR6/CYTH2/ADCY9/LPAR1/PTPN11/PIP5K1A/MAP2K2/RHOA/PLCB3/PIK3R3	0.726383624435595
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1556	149/9376	1.13234761305015	GNAI3/NDUFA5/NDUFC2/NDUFB3/ADCY3/GNG12/ADCY6/GNB4/NDUFB6/NDUFA12/NDUFV2/NDUFA7/GNAI1/NDUFB8/MAPK9/NDUFA6/NDUFB5/NDUFA8/NDUFS3/GNG5/ADCY9/GNG11/NDUFA2/NDUFA4/NDUFS4/PLCB3/MAPK10/CNR1	0.726383624435595
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1556	99/9376	1.15644880683441	PDGFA/SOS1/CHPT1/KRAS/PIK3CA/JUN/HIF1A/SP1/MAP2K1/WASF3/MAPK9/NRAS/RAF1/RHEB/PIP5K1A/MAP2K2/MAPK10/PIK3R3/FOS	0.6980284636837
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1556	168/9376	1.11188639980414	IFNGR1/SOCS2/PDGFA/SOS1/STAT2/CCND2/MCL1/PIK3CA/IFNAR1/SOCS1/IFNGR2/STAT5B/GHR/CCND3/STAT1/IL15RA/MYC/STAM2/SOCS4/FHL1/RAF1/STAT6/EP300/IL6ST/JAK3/PIM1/LIF/PTPN11/SOCS3/PIK3R3/STAT5A	0.652734162541563
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1556	38/9376	1.26856988228927	GFPT1/PGM3/UAP1/GNPDA2/HK1/FPGT/GALK2/GALK1	0.739961681007446
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1556	134/9376	1.12419905613322	PPP1CB/AVPR1A/ACTG2/AGTR1/ADCY3/ADCY6/PPP1CC/ARHGEF12/GNAS/GUCY1A2/MYLK/PRKG1/GUCY1B1/CALM2/GUCY1A1/MAP2K1/PPP1R14A/PLA2G2A/RAF1/ADCY9/CALM1/CALM3/MAP2K2/RHOA/PLCB3	0.645914107992098
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1556	17/9376	1.41781339785271	SCP2/CYP7B1/HSD17B4/CH25H	0.769093528924543
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1556	17/9376	1.41781339785271	SEPHS2/INMT/PAPSS1/TXNRD1	0.769093528924543
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1556	170/9376	1.09880538333585	GADD45A/GSTM3/HGF/PTEN/SOS1/CTNNB1/SMAD4/KRAS/RB1/PIK3CA/SMARCE1/WNT6/TGFBR2/TXNRD1/MAP2K1/FZD10/BRD7/MYC/NRAS/PHF10/RAF1/CSNK1A1/ARID1B/FZD3/BAX/SMARCD1/WNT3A/MAP2K2/FZD2/TGFB3/PIK3R3	0.579904716315366
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1556	28/9376	1.29122291590158	HADHB/PPT1/HADH/ELOVL5/HSD17B12/MBLAC2	0.688386377994941
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1556	12/9376	1.50642673521851	COQ5/COQ2/GGCX	0.783003319706444
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1556	85/9376	1.13425071828217	DUT/HDDC2/NT5C3B/HPRT1/ADA/GMPS/DGUOK/NME1/RRM2B/AK6/AK3/CMPK1/ENPP1/CANT1/GMPR2/IMPDH2	0.554602609659264
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1556	126/9376	1.09993063206431	GNAI3/COL3A1/PPP1CB/COL1A2/ADCY3/PIK3CA/ADCY6/PPP1CC/ARHGEF12/GNAS/GUCY1A2/MYLK/PRKG1/GUCY1B1/GUCY1A1/MYL12B/STIM1/GNAI1/ADCY9/RAP1A/RHOA/PLCB3/PIK3R3	0.503732647070898
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1556	18/9376	1.3390459868609	MMADHC/LMBRD1/ZNF143/THAP11	0.642229718643866
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/1556	203/9376	1.06859827522889	PTK2/HGF/PPP1CB/PTEN/LAMB1/PDGFA/SOS1/COL4A1/COL1A2/CTNNB1/BIRC2/CCND2/PIK3CA/THBS3/PPP1CC/MYLK/CDC42/JUN/MYL12B/CCND3/LAMA3/VCL/ITGA7/LAMA2/EMP2/MAP2K1/MAPK9/RAF1/PIP5K1A/RAP1A/VEGFB/RHOA/CAV2/ITGA11/MAPK10/PIK3R3	0.440750259375583
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1556	75/9376	1.12479862896315	HSPA5/HSP90B1/PDIA4/ADCY3/GPX8/ADCY6/GNAS/ATP1B2/CANX/GPX3/ADCY9/CREB3L4/PLCB3/ATF2	0.484019302765623
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1556	41/9376	1.1757476957803	AOC3/GATM/GCSH/DLD/ALDH7A1/ALAS1/GRHPR/SHMT2	0.503050360922985
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1556	30/9376	1.20514138817481	NFKB1/DHFR/GART/IKBKB/ABCC5/SHMT2	0.501981933519506
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/1556	193/9376	1.06152350253739	GNAI3/PTK2/SOS1/STAT2/CXCL2/KRAS/ADCY3/CXCL1/GNG12/NFKB1/PIK3CA/ADCY6/GNB4/CDC42/NFKBIA/STAT5B/STAT1/GNAI1/MAP2K1/NRAS/CXCL3/RAF1/JAK3/GRK5/GNG5/ADCY9/IKBKB/CXCL14/GNG11/RAP1A/RHOA/PLCB3/CCL26/PIK3R3	0.385225007467961
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	14/1556	76/9376	1.10999864700311	GNAI3/SSTR2/CAMK2D/ADCY3/ADCY6/GNAS/ATP1B2/MYLK/CALM2/GNAI1/ADCY9/CALM1/CALM3/PLCB3	0.429476814460051
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/1556	82/9376	1.10226346479403	HSPA5/HSPA1A/HSPA1B/CALR/HSP90AB1/HSP90AA1/HSPA8/HSPA4/PDIA3/NFYB/B2M/TAP1/HSPA2/HLA-F/CANX	0.414871071595733
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1556	59/9376	1.1234368872816	GSTM3/ODC1/GPX8/TXNDC12/LAP3/GGCT/GPX3/RRM2B/GGT5/SRM/SMS	0.424248169967885
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1556	19/9376	1.26856988228927	GCSH/DLD/DLST/PDHB	0.522700424204531
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1556	65/9376	1.11243820446905	AGTR1/ADCY3/ADCY6/GNAS/SP1/CACNA1H/PBX1/ADCY9/CREB3L4/PLCB3/ATF2/NR4A1	0.405750884027438
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1556	54/9376	1.11587165571741	CISD1/ADI1/AMD1/MAT2A/MDH1/SRM/LDHB/MTAP/MRI1/SMS	0.380896166145352
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1556	60/9376	1.10471293916024	PTK2/KRAS/PIK3CA/PPP3CC/CDC42/MAP2K1/NRAS/RAF1/MAP2K2/PPP3CA/PIK3R3	0.362951247218101
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1556	37/9376	1.13999861043563	GFPT1/PGM3/UAP1/HK1/FPGT/GALK2/GALK1	0.380593579341388
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1556	32/9376	1.12982005141388	HIBCH/SUCLA2/DLD/ACSS2/SUCLG1/LDHB	0.328123555657229
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/1556	98/9376	1.04527569382509	MARCKSL1/ARF6/PIK3CA/CDC42/ARPC5L/MAP2K1/WASF3/ACTR2/ARPC3/RAF1/ARPC1B/ACTR3/ASAP1/CFL2/PIP5K1A/ARPC4/PIK3R3	0.200973143767438
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1556	98/9376	1.04527569382509	CAMK2D/AGTR1/ADCY3/ADCY6/GNAS/ATP1B2/PRKD3/CALM2/ATF1/CACNA1H/ADCY9/CALM1/CREB3L4/CALM3/PLCB3/ATF2/NR4A1	0.200973143767438
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	26/1556	154/9376	1.01732714586185	GNAI3/CAMK2D/PPP1CB/AGTR1/ATP2A2/CACNA2D1/ADCY3/ADCY6/PPP1CC/TPM4/GNAS/ATP1B2/CALM2/PPP2CA/GNAI1/PPP2CB/SCN1B/PPP2R2D/PPP2R5E/ADCY9/CALM1/CREB3L4/CALM3/PLCB3/ATF2/PPP2R5C	0.096707886212255
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1556	65/9376	1.0197350207633	TRPC4/KRAS/PIK3CA/TRPC1/MAP2K1/NRAS/CACNA1H/RAF1/MAP2K2/PLCB3/PIK3R3	0.0712169156277494
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1556	59/9376	1.02130626116509	GNAI3/ADCY3/PIK3CA/ADCY6/GNAS/IRS1/PRKG1/GNAI1/ADCY9/PIK3R3	0.0732288581412976
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1556	23/9376	1.04794903319548	ATP1B2/GLS/GLUD1/MDH1	0.102696434029749
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/1556	115/9376	0.99555158153571	GNAI3/CAMK2D/KRAS/ADCY3/GNG12/PIK3CA/ADCY6/GNB4/ACHE/GNAI1/MAP2K1/NRAS/GNG5/ADCY9/GNG11/CREB3L4/PLCB3/PIK3R3/FOS	-0.0214098029804905
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1556	17/9376	1.06336004838954	CSAD/GGT5/ADO	0.116630542388485
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	19/1556	116/9376	0.986969240315575	GNAI3/PTK2/JAM3/VCAM1/CTNNB1/PIK3CA/CDC42/MYL12B/VCL/GNAI1/MSN/ESAM/CD99/CLDN12/SIPA1/PTPN11/RAP1A/RHOA/PIK3R3	-0.0629912598928477
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1556	36/9376	1.00428449014567	MCM3/RFC5/PCNA/PRIM2/RFC1/RPA3	0.0114885182521331
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1556	61/9376	0.98782080997935	MT1E/MT1M/MT1X/MT1F/ATP1B2/HMOX2/CYBRD1/MT2A/HEPH/MT1A	-0.04256757915765
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1556	49/9376	0.983788888305965	GNAI3/NFKB1/GNAS/JUN/GNAI1/CDK5/CREB3L4/ATF2	-0.0507489320759207
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1556	154/9376	0.978199178713318	MTHFD2/MOCS2/ALDH3A2/DHFR/PTS/DLD/MAT2A/ALDH2/NADK2/NME1/MOCS1/RDH11/ALAS1/COQ5/GCH1/AK6/PANK3/COQ2/AK3/CMPK1/AFMID/PNPO/AKR1A1/SHMT2/GGCX	-0.121676781689022
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1556	99/9376	0.973851626807925	CAMK2D/PPP1CB/ADCY3/PIK3CA/ADCY6/PPP1CC/GNAS/CALM2/NGF/MAPK9/ADCY9/CALM1/CALM3/PLCB3/MAPK10/PIK3R3	-0.116666334096181
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1556	31/9376	0.971888216270006	ALDH3A2/ALDH2/ALDH7A1/ALDH9A1/AKR1A1	-0.0699305034880054
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1556	38/9376	0.951427411716953	SIRT1/NNMT/NADK2/NUDT12/ENPP1/SIRT7	-0.133826822912682
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1556	78/9376	0.927031837057544	IFNGR1/MARCKSL1/NFKB1/IFNGR2/JUN/NFKBIA/STAT1/TRAF6/IRAK4/TGFB3/TLR4/FOS	-0.288650956493604
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1556	33/9376	0.91298590013243	ACO1/IDH3A/DLD/DLST/PDHB	-0.223352328999593
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1556	91/9376	0.927031837057544	GNAI3/PDE3A/ADCY3/GNG12/ADCY6/GNAS/GNB4/GNAI1/GRK5/GNG5/ADCY9/PDE1A/GNG11/PDE4B	-0.311996852409186
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/1556	66/9376	0.91298590013243	IFNGR1/NFATC1/NFKB1/IFNGR2/JUN/STAT1/IL18R1/STAT6/TGFB3/TLR4	-0.316427206497551
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1556	27/9376	0.892697324573931	SCP2/HSD17B4/ELOVL5/HSD17B12	-0.249055943787435
NA	NA	hsa04519	Cadherin signaling	64/1556	404/9376	0.954567436178065	MPDZ/STK3/PTK2/PPP1CB/SHOC2/CTNNB1/SAV1/KRAS/MOB1A/NFKB1/YAP1/PPP1CC/CDH6/PCDHGB7/RYK/PCDH1/WNT6/DAAM2/ENAH/PCDH18/CDC42/NFKBIA/YWHAQ/RRAS/VCL/PCDHGA10/CYFIP1/ARPC5L/MAP2K1/FZD10/MYO1B/LHFPL6/MAPK9/NRAS/ACTR2/ARPC3/RAF1/EP300/CSNK1A1/SCN1B/WWTR1/ARPC1B/FAT1/ACTR3/FZD3/PCDH10/IKBKB/TEAD2/PRICKLE2/PCDHGA12/WNT3A/MAP2K2/FZD2/RHOA/ABI2/VIM/ARPC4/MYO1E/PSEN1/MAPK10/PCDHGA9/BRK1/YWHAB/NCKAP1	-0.416390059890581
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1556	54/9376	0.892697324573931	WDR48/HES1/MLH1/ERCC4/FAN1/PMS2/RPA3/ERCC1	-0.352728002667059
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1556	41/9376	0.881810771835225	ABRAXAS1/NBN/BABAM1/RAD50/MRE11/RPA3	-0.338298227020987
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1556	93/9376	0.907095668518672	ADCY3/ADCY6/GNAS/GUCY1A2/ATP1B2/PRKG1/GUCY1B1/CALM2/GUCY1A1/ADCY9/PRH1/CALM1/CALM3/PLCB3	-0.401624612590694
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1556	28/9376	0.860815277267719	A4GALT/B4GALT3/B4GALT1/B4GALT4	-0.3290018124339
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1556	88/9376	0.890161252629119	C7/F3/CD46/PROCR/C1S/PLAU/PROS1/PLAT/C1R/CFH/CFD/CFHR1/CFI	-0.461766967204245
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1556	69/9376	0.873290860996237	SOS1/KRAS/PIK3CA/MAP2K1/MAPK9/NRAS/RAF1/MAP2K2/MAPK10/PIK3R3	-0.471210203786658
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1556	89/9376	0.880159440801825	GNAI3/ADCY3/GNG12/ADCY6/GNB4/GLS/GNAI1/SLC38A2/NSF/GABARAPL2/GNG5/ADCY9/GNG11	-0.506696804496097
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1556	76/9376	0.872141794073874	SCP2/HMGCS1/SORBS1/DBI/ACSL3/PPARD/ACADM/CPT1A/PLIN2/FABP5/CD36	-0.499207367361314
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/1556	115/9376	0.890756678216162	JUND/GNAI3/ADCY3/ADCY6/GNAS/MEF2D/GNAI1/SP1/MAP2K1/RAF1/ADCY9/CREB3L4/RHOA/PLCB3/ATF2/PDE4B/FOS	-0.525777422943001
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1556	15/9376	0.803427592116538	ST6GALNAC4/ST3GAL2	-0.339855358960938
NA	NA	hsa04517	IgSF CAM signaling	46/1556	299/9376	0.927031837057544	MPDZ/PTK2/JAM3/PMP22/DYNLL1/ARF6/CTNNB1/ABL1/PIK3CA/NRP1/WASL/SORBS1/MYLK/NCK2/TUBB2A/TRPC6/CDC42/MYL12B/CASK/VCL/ARPC5L/MSN/MAP2K1/ESAM/TRAF6/MAPK9/SLIT3/NECTIN3/UNC5C/ACTR2/ARPC3/PARD6G/ARPC1B/ROBO1/ACTR3/NECTIN2/KIRREL1/PTPN11/RAP1A/MAP2K2/RHOA/MAP2/EPB41L2/ARPC4/MAPK10/PIK3R3	-0.571985338691741
NA	NA	hsa04518	Integrin signaling	23/1556	154/9376	0.899943244416252	PTK2/HGF/LAMB1/VCAM1/PDGFA/COL4A1/COL1A2/CTNNB1/CCND2/PIK3CA/THBS3/NCK2/CDC42/CCND3/LAMA3/VCL/ITGA7/LAMA2/ITGAE/VEGFB/ITGA11/PIK3R3/ARHGEF6	-0.558446117491576
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1556	37/9376	0.814284721739735	GFPT1/GLS/GLUD1/NIT2/PPAT	-0.504876743215648
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1556	37/9376	0.814284721739735	ADH1B/AOC3/ADH5/COMT/FAHD1	-0.504876743215648
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1556	23/9376	0.785961774896613	GLS/GLUD1/ARG2	-0.458423475913681
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1556	23/9376	0.785961774896613	B3GALNT2/B4GALT3/B4GALT1	-0.458423475913681
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	34/1556	226/9376	0.906522283140342	GNAI3/SSTR2/CAMK2D/PPP1CB/PDE3A/ATP2A2/NFATC1/ADCY3/NFKB1/PIK3CA/ADCY6/PPP1CC/GNAS/ATP1B2/CALM2/JUN/NFKBIA/RRAS/GNAI1/MAP2K1/MAPK9/RAF1/EP300/ADCY9/CALM1/RAP1A/CREB3L4/CALM3/MAP2K2/RHOA/PDE4B/MAPK10/PIK3R3/FOS	-0.63451052003406
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1556	16/9376	0.753213367609255	A4GALT/ST3GAL2	-0.440687525011279
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1556	65/9376	0.83432865335179	PLPP5/ALDH3A2/ALDH2/ALDH7A1/AGPAT5/LPIN3/ALDH9A1/AKR1A1/MBOAT2	-0.597851021171627
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/1556	183/9376	0.889038728981415	XPO1/RIOK2/NMD3/RAN/XRN1/REXO2/NOP10/BMS1/GTPBP4/SBDS/NXT1/UTP18/RPP30/NHP2/POP7/NOB1/AK6/CSNK2A1/RCL1/WDR3/RPP25L/XRN2/GAR1/WDR75/HEATR1/CSNK2B/UTP14A	-0.676169217318146
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1556	38/9376	0.792856176430794	KRAS/PIK3CA/IRS1/ATP1B2/PIK3R3	-0.570721074872745
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1556	31/9376	0.777510573016005	RPE/PRPS1/PFKM/RPIA	-0.553461772443417
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1556	59/9376	0.817045008932073	DUT/HDDC2/NT5C3B/NME1/RRM2B/CMPK1/ENPP1/CANT1	-0.628809765511877
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1556	17/9376	0.708906698926357	PCDH1/LAMP2	-0.535832444147573
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1556	32/9376	0.753213367609255	HK1/B4GALT1/PFKM/GALK1	-0.623759630556316
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1556	75/9376	0.803427592116538	RPE/ACO1/IDH3A/MAT2A/PRPS1/ARG2/PFKM/RPIA/ALDH18A1/SHMT2	-0.762386899577273
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	34/1556	233/9376	0.879287708110374	SGCB/COL3A1/CSRP2/ACTG2/COL4A1/SYNPO2/COL1A2/COL5A2/THBS3/TPM4/DAAM2/ATP1B2/SUN1/CAPZA2/TMOD2/SGCE/CAPZA1/VCL/LBR/ITGA7/LAMA2/SNTB2/LMNB2/FHL2/FHL1/ELN/SDC4/CSRP1/TMOD3/NID1/TMOD1/TMEM43/ITGA11/VIM	-0.832285166250843
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1556	18/9376	0.669522993430449	ACSL3/CBR4	-0.625998133505437
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	16/1556	116/9376	0.831131991844695	GNAI3/ADCY3/GNG12/ADCY6/GNAS/GNB4/GLS/PPP3CC/TRPC1/GNAI1/SLC38A2/GNG5/ADCY9/GNG11/PPP3CA/PLCB3	-0.816315306774659
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1556	48/9376	0.753213367609255	LAMP2/TSG101/CHMP1B/PDCD6IP/CLDN12/CHMP4A	-0.764601313390346
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1556	63/9376	0.765169135349084	GADD45A/CTNNB1/WNT6/FZD10/FZD3/BAX/WNT3A/FZD2	-0.834195242002904
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/1556	70/9376	0.774733749540947	SGCB/CASP3/ABL1/EIF4G2/SGCE/LAMA2/SNTB2/HLA-F/CYCS	-0.843821689431637
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1556	49/9376	0.737841666229474	C1GALT1C1/POFUT2/GALNT7/B4GALT3/B4GALT1/EOGT	-0.820687422599918
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1556	27/9376	0.669522993430449	HMGCS1/HADH/OXCT1	-0.767056948434949
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1556	105/9376	0.803427592116538	SGCB/ATP2A2/CACNA2D1/ADCY3/ADCY6/TPM4/GNAS/SGCE/ITGA7/LAMA2/SNTB2/ADCY9/ITGA11/TGFB3	-0.903526665978658
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1556	99/9376	0.791254446781439	SGCB/ATP2A2/CACNA2D1/TPM4/SGCE/ITGA7/LAMA2/SNTB2/PRKAG1/PRKAB2/ITGA11/TGFB3/PRKAA1	-0.931361131876062
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1556	50/9376	0.723084832904884	HGF/VCAM1/THBS3/CD36/TGFB3/TLR4	-0.875731755058214
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/1556	133/9376	0.815509210043103	IFNGR1/CASP3/SOS1/FAS/NFATC1/KRAS/PIK3CA/IFNAR1/PPP3CC/IFNGR2/MAP2K1/NRAS/RAF1/MICB/PTPN11/MAP2K2/PPP3CA/PIK3R3	-0.955830957577794
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1556	20/9376	0.602570694087404	LBR/HSD17B7	-0.793627736400032
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1556	36/9376	0.669522993430449	C1GALT1C1/GALNT7/ST6GALNAC4/ST3GAL2	-0.886147707847857
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1556	155/9376	0.816386101666805	CALR/SEC22B/SEC61B/THBS3/TAP1/LAMP2/C1R/STX12/TUBB2A/COLEC11/SEC61G/HLA-F/M6PR/RAB5A/CANX/DYNC1LI2/RAB7A/RAB5B/CD36/TLR4/ATP6V1G1	-1.02818069972724
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1556	115/9376	0.785961774896613	DUSP1/GNAI3/CASP3/KRAS/GNG12/GNAS/GNB4/TRPC1/GNAI1/MAP2K1/NRAS/RAF1/GNG5/GNG11/PLCB3	-1.03014504290551
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1556	29/9376	0.623348993883521	CALM2/CALM1/CALM3	-0.906126991929281
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1556	52/9376	0.695273877793158	ADCY3/ADCY6/GNAS/HSD17B2/ADCY9/HSD17B7	-0.982872722821102
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1556	12/9376	0.502142245072836	CD46	-0.769754532570971
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1556	45/9376	0.669522993430449	ABCA8/ABCA6/TAP1/ABCA1/ABCC5	-0.991220940503856
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/1556	103/9376	0.760526118751092	ACE2/COL15A1/COL21A1/COL3A1/COL4A1/COL1A2/COL5A2/ATP1B2/SLC38A2/SLC36A4/ELN/COL14A1/SLC1A5	-1.09006825803106
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/1556	89/9376	0.744750296063083	LAMB1/COL4A1/COL1A2/THBS3/CD47/LAMA3/ITGA7/LAMA2/SDC4/CD36/ITGA11	-1.07921900731068
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1556	53/9376	0.682155502740457	ADCY6/GNAS/ATP1B2/CLTA/ADCY9/PLCB3	-1.03505123459411
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1556	46/9376	0.654968145747178	HMOX2/FXN/ALAS1/HEPH/HCCS	-1.04636774582027
NA	NA	hsa04981	Folate transport and metabolism	3/1556	31/9376	0.583132929762003	DHFR/ABCC5/SHMT2	-1.03699304139883
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1556	48/9376	0.627677806341045	PIK3CA/ATP1B2/HK1/PLCB3/PIK3R3	-1.15353913426425
NA	NA	hsa04081	Hormone signaling	29/1556	219/9376	0.797924663403411	GNAI3/SSTR2/AVPR1A/AGTR1/SMAD4/ADCY3/GNG12/PIK3CA/ADCY6/GNAS/GNB4/IRS1/PRKG1/STAT5B/GHR/GNAI1/ADIPOR1/SMAD5/SLC16A2/GNG5/ADCY9/GNG11/HEPH/STK11/RHOA/PLCB3/ADIPOR2/PIK3R3/STAT5A	-1.34972663818199
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1556	87/9376	0.692609993203912	ASPH/ATP2A2/CACNA2D1/TPM4/ATP1B2/UQCRFS1/UQCRH/UQCRC2/COX7A2L/COX7B	-1.28484857565999
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1556	102/9376	0.708906698926357	RAB8A/ATP2A2/ADCY3/ADCY6/GNAS/ATP1B2/TRPC1/PLA2G2A/ADCY9/RAP1A/RHOA/PLCB3	-1.31851722950749
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1556	15/9376	0.401713796058269	ACP1	-1.03438104457945
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1556	66/9376	0.639090130092701	CYP7B1/HSD17B2/HSD17B11/SRD5A3/COMT/HSD17B12/HSD17B7	-1.31245053509683
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1556	104/9376	0.695273877793158	ETNK1/PLPP5/CHPT1/LPGAT1/ACHE/PLA2G2A/GNPAT/AGPAT5/LPCAT3/LPIN3/CRLS1/MBOAT2	-1.39388421914264
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1556	16/9376	0.376606683804627	AOC3	-1.1131950501587
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1556	35/9376	0.516489166360632	HK1/FPGT/PFKM	-1.27829356760452
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1556	36/9376	0.502142245072836	HK1/GYG1/ENPP1	-1.33496582089785
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1556	17/9376	0.354453349463179	GLUD1	-1.18829543068363
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	43/1556	323/9376	0.802183896153509	CDKN1B/SPRY2/CASP3/PTEN/PDGFA/SOS1/KRAS/CCND2/RASSF1/ABL1/MCL1/NFKB1/HOXD10/PIK3CA/PLAU/SOCS1/IRS1/GLS/SIRT1/MDM2/UBE2I/MDM4/CCNG1/HDAC1/MAP2K1/NOTCH1/MYC/NRAS/EZH2/RAF1/NOTCH2/EP300/FZD3/PIM1/IKBKB/DDIT4/HNRNPK/DICER1/WNT3A/MAP2K2/RHOA/VIM/PIK3R3	-1.61381483274249
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1556	37/9376	0.488570833043841	VCAM1/FAS/PLCB3	-1.39034706577268
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1556	86/9376	0.630597237998446	CAMK2D/ADCY3/ADCY6/GNAS/ATP1B2/ADCY9/CREB3L4/PLCB3/ATF2	-1.53507134531341
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/1556	86/9376	0.630597237998446	SGCB/CTNNB1/ATP2A2/CACNA2D1/SGCE/ITGA7/LAMA2/SNTB2/ITGA11	-1.53507134531341
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1556	18/9376	0.334761496715224	NEU1	-1.26011205958009
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1556	63/9376	0.573876851511813	PTGES3/PTGR1/CBR1/CYP2U1/PLA2G2A/GGT5	-1.51372735225653
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1556	55/9376	0.547791540079458	UGCG/DEGS1/CERS6/CERS2/NEU1	-1.50029213175833
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1556	38/9376	0.475713705858477	TAP1/ADA/JAK3	-1.44450957879287
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/1556	95/9376	0.634284941144635	CXCL2/CXCL1/ANGPT1/JUN/CSF1/CXCL3/TGFB3/TLR4/ATP6V1G1/FOS	-1.59806455038652
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1556	19/9376	0.317142470572318	IDS	-1.32900203574825
Human Diseases	Substance dependence	hsa05034	Alcoholism	23/1556	191/9376	0.725608689215198	GNAI3/PPP1CB/SOS1/KRAS/GNG12/PPP1CC/GNAS/GNB4/HAT1/CALM2/HDAC1/GNAI1/MAP2K1/NRAS/RAF1/HDAC3/GNG5/CAMKK2/CALM1/GNG11/CREB3L4/CALM3/ATF2	-1.70897030162537
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	32/1556	254/9376	0.759144181527438	HGF/CAMK2D/EDNRB/AVPR1A/ASPH/PDGFA/VDAC3/AGTR1/FGF7/ATP2A2/NFATC1/ADCY3/GNAS/MYLK/FGF2/PPP3CC/CALM2/STIM1/NGF/VDAC1/VDAC2/CACNA1H/PHKG1/SLC25A5/ADCY9/PDE1A/CALM1/VEGFB/CALM3/PPP3CA/PLCB3/STIM2	-1.7358653116451
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1556	82/9376	0.58787384789015	GSTM3/DUT/HPRT1/GMPS/NME1/RRM2B/CMPK1/IMPDH2	-1.6719482241562
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1556	20/9376	0.301285347043702	UAP1	-1.39526532182101
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/1556	100/9376	0.602570694087404	TNFRSF1A/ACKR3/CXCL2/CXCL1/CSF1/IL18R1/CXCL3/IL6ST/CXCL14/CCL26	-1.78224159910711
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1556	68/9376	0.531680024194768	ADH1B/ADH5/ALDH1A1/DHRS4L2/PNPLA4/RDH11	-1.72884480672656
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1556	51/9376	0.472604465950905	CHPT1/PLA2G2A/PAFAH1B1/AGPS	-1.68455103825744
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1556	43/9376	0.42039815866563	ABCA1/PLA2G2A/CD36	-1.69918399765879
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1556	44/9376	0.410843655059593	HSPD1/FAS/HLA-F	-1.74725620065751
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1556	24/9376	0.251071122536418	HS2ST1	-1.6386303950997
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1556	36/9376	0.334761496715224	RPE/AKR1A1	-1.78378393394785
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1556	26/9376	0.231757959264386	PLA2G2A	-1.74970968626365
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1556	26/9376	0.231757959264386	HES1	-1.74970968626365
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1556	26/9376	0.231757959264386	LMBRD1	-1.74970968626365
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/1556	194/9376	0.652267246177086	DYNLT3/ACTG2/DYNLL1/ACTR10/TPM4/KIF2A/CAPZA2/DYNLT1/TUBB2A/MYL12B/CAPZA1/DYNC2LI1/DCTN4/TUBG1/DCTN6/MYO1B/DYNC1LI2/KIF3C/KIF18A/MYO1E/DNAH11	-2.1830560111763
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1556	39/9376	0.309010612352515	FAS/HLA-F	-1.92879938791724
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1556	28/9376	0.21520381931693	ATP6V1G1	-1.85508409807716
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1556	30/9376	0.200856898029135	PLA2G2A	-1.95550689724433
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1556	45/9376	0.267809197372179	FAS/HLA-F	-2.19610696533067
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1556	79/9376	0.381373857017344	ADH1B/GSTM3/ADH5/CBR1/EPHX1	-2.46296055978481
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1556	90/9376	0.401713796058269	ADCY3/ADCY6/GNAS/ATP1B2/ADCY9/EPHX1	-2.5439171402179
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1556	50/9376	0.241028277634961	MAP3K14/IL15RA	-2.40021391908083
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1556	54/9376	0.223174331143483	FAS/HLA-F	-2.55360050910429
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1556	70/9376	0.258244583180316	GSTM3/CBR1/EPHX1	-2.77853121668409
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1556	73/9376	0.247631792090714	ADH1B/GSTM3/ADH5	-2.87850781768925
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1556	195/9376	0.494416979764023	VDAC3/NFKB1/PIK3CA/HAT1/HDAC1/CASP4/VDAC1/MAP2K1/VDAC2/RAF1/HDAC3/SLC25A5/MAP2K2/PLCB3/TLR4/PIK3R3	-3.18237863345019
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1556	86/9376	0.28026543911042	ADCY6/PDE1A/PLCB3/TAS2R14	-2.99089236546821
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1556	99/9376	0.304328633377477	C1S/C1R/CFH/CFD/CFI	-3.10388059262241
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/1556	79/9376	0.228824314210406	NSF/CLTA/ATP6V1G1	-3.07031204599128
NA	NA	hsa04082	Neuroactive ligand signaling	15/1556	199/9376	0.454199015643772	GNAI3/P2RY14/OGFRL1/ADCY3/GNG12/ADCY6/GNAS/GNB4/ACHE/GNAI1/OGFR/GNG5/ADCY9/GNG11/PLCB3	-3.47134313535206
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/1556	160/9376	0.376606683804627	JAM3/VCAM1/ESAM/HLA-F/NECTIN3/CD99/CLDN12/SDC4/NECTIN2/NRXN3	-3.54762705199632
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/1556	298/9376	0.525732820344715	IFNGR1/TNFRSF1A/ACKR3/FAS/CXCL2/CXCL1/IFNAR1/RELL1/IFNGR2/BMP5/TNFSF12/TGFBR2/CSF1/GHR/IL18R1/NGF/IL15RA/EDA/TNFSF9/CXCL3/IL6ST/CXCL14/LIF/TGFB3/CCL26/TNFRSF12A	-3.71127530983479
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1556	143/9376	0.337102486202743	C7/C1S/C1R/SNRPD1/SNRPB/SSB/TRIM21/SNRPD3	-3.56311672009989
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/1556	100/9376	0.180771208226221	CSF1/KITLG/CD36	-3.67376942304952
NA	NA	hsa04382	Cornified envelope formation	9/1556	217/9376	0.249914112755144	COL4A1/UGCG/PPP2CA/LAMA3/PPP2CB/CLDN12/PPP2R2D/PPP2R5E/PPP2R5C	-4.98659261784698
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/1556	370/9376	0.24428541652192	SSTR2/PGRMC1/P2RY14/EDNRB/AVPR1A/AGTR1/OGFRL1/GHR/OGFR/S1PR3/LPAR6/LPAR1/CHRNB1/NR3C1/CNR1	-6.61576015130392
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1556	449/9376	0.120782544471863	CAMK2D/ADCY3/NCALD/PRKG1/CALM2/OR51E1/PDE1A/CALM1/CALM3	-8.51635512507785