category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/111	248/9376	4.0871839581517	TXN/ACTG1/SKP1/DYNLL1/MYL12B/CDC42/MYL12A/CXCL8/ACTR3/DYNLT3/RIPK2/RALA	5.39293206294483
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/111	174/9376	4.85450968209589	HSPA1A/DNAJA1/SKP1/SEC61G/HSPA1B/SEC61B/HSPA8/HSPH1/CRYAB/UBE2D1	5.6172928567996
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/111	253/9376	4.00640957162696	ACTG1/SKP1/MYL12B/CDC42/MYL12A/CXCL8/MAP1LC3B/UBE2D1/ACTR3/UBE2N/VDAC1/RIPK2	5.30596015534502
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/111	216/9376	3.91057724391058	SOD2/HSPA1A/CXCL1/HSPA1B/HSPA8/RAP1B/CDC42/CXCL8/CALM2/VCAM1	4.73677421579609
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/111	50/9376	8.44684684684685	HBB/HBA2/CXCL8/VCAM1/HBA1	5.77875303494645
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	11/111	268/9376	3.46698937743714	TXN/DUSP1/ATP5MC3/NDUFB3/CALM2/PSMA3/PSMA5/UCHL1/NDUFA4/COX6C/VDAC1	4.48484647903247
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/111	56/9376	7.54182754182754	HSPA1A/CXCL1/HSPA1B/HSPA8/CXCL8	5.37414727718375
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/111	157/9376	4.30412578183279	GADD45A/GADD45G/CXCL8/CALM2/RHEB/PPP1CB/PTEN/VDAC1	4.56971280088803
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/111	62/9376	6.81197326358617	SOD2/HSPA1A/HSPA1B/HSPA8/CRYAB	5.02545920050856
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/111	37/9376	9.13172632091551	HBB/HBA2/VCAM1/HBA1	5.42447664658774
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/111	142/9376	4.1639385864738	TXN/ACTG1/DUSP1/MGST1/SUMO2/CALM2/VCAM1	4.15816480215995
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/111	275/9376	3.07158067158067	HSPA1A/HSPA1B/HSPA8/ATP5MC3/NDUFB3/PSMA3/PSMA5/NDUFA4/COX6C/VDAC1	3.81634875639619
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/111	187/9376	3.61362431950667	TXN/CXCL1/ANTXR1/CXCL8/MAP1LC3B/TXNIP/VDAC1/RIPK2	3.95142966382847
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/111	116/9376	4.3690587138863	ACTG1/MYL12B/RAP1B/CDC42/MYL12A/VCAM1	3.99628540301176
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/111	203/9376	3.32880663915147	SPP1/ACTG1/MYL12B/RAP1B/CDC42/MYL12A/PPP1CB/PTEN	3.67155610060713
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/111	51/9376	6.62497791909557	ACTG1/SEC61G/SEC61B/ATP6V1G1	4.4086528800213
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/111	93/9376	4.54131550905745	ACTG1/MYL12B/RAP1B/CDC42/MYL12A	3.75652545641493
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/111	227/9376	2.97686232487995	SOD2/MGST1/ATP5MC3/NDUFB3/NDUFA4/COX6C/PTEN/VDAC1	3.30009889920244
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/111	31/9376	8.1743679163034	SEC61G/SEC61B/SRP9	4.37924511556335
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/111	138/9376	3.67254210732472	ATP5MC3/ATP6V1G1/NDUFB3/NDUFA4/PPA1/COX6C	3.46178057368902
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/111	105/9376	4.02230802230802	CXCL1/GADD45A/GADD45G/CXCL8/VCAM1	3.40874488043759
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	8/111	250/9376	2.70299099099099	HSPA1A/HSPA1B/HSPA8/ARF4/CDC42/SNX3/ACTR3/SPART	2.98721539213373
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/111	110/9376	3.83947583947584	SKP1/DCN/ID4/BAMBI/ID1	3.27878385654411
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/111	71/9376	4.75878695597005	CXCL1/CDC42/ATP6V1G1/CXCL8	3.47971049054836
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/111	205/9376	2.884289167216	ATP5MC3/NDUFB3/PPP1CB/NDUFA4/COX6C/PTEN/VDAC1	2.98566138305765
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	10/111	368/9376	2.29533881707795	ACTG1/SRSF7/ATP5MC3/NDUFB3/PSMA3/MAP1LC3B/PSMA5/NDUFA4/COX6C/VDAC1	2.77470947035748
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/111	76/9376	4.4457088667615	GADD45A/GADD45G/CALM2/PTEN	3.30117325606278
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/111	77/9376	4.38797238797239	GADD45A/CDC42/GADD45G/RALA	3.26731883748737
Organismal Systems	Immune system	hsa04611	Platelet activation	5/111	126/9376	3.35192335192335	ACTG1/MYL12B/RAP1B/MYL12A/PPP1CB	2.90912234482233
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/111	47/9376	5.39160437032777	LDHA/LDHB/ADH5	3.30353571808632
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/111	232/9376	2.54861758310034	TMSB4X/ACTG1/MYL12B/CDC42/MYL12A/PPP1CB/ACTR3	2.61423416138468
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	7/111	238/9376	2.48436671966084	RPS7/ISG15/CXCL8/MX1/RPL22L1/RPL26L1/RPS10	2.53880021308467
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/111	93/9376	3.63305240724596	GADD45A/GADD45G/PTEN/CKS2	2.79306612771328
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/111	139/9376	3.03843411757081	HSPA1A/HSPA1B/HSPA8/KRT10/CALM2	2.65010464703929
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/111	94/9376	3.59440291355185	CXCL1/CEBPB/CXCL8/S100A9	2.76697339866415
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/111	300/9376	2.25249249249249	HSPA1A/GADD45A/HSPA1B/HSPA8/RAP1B/DUSP1/CDC42/GADD45G	2.41330899089982
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/111	95/9376	3.5565670934092	CXCL1/ATP6V1G1/CTSK/CXCL8	2.74123347553622
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/111	480/9376	1.93573573573574	ATP5MC3/DKK1/NDUFB3/CALM2/PSMA3/MAP1LC3B/PSMA5/UCHL1/NDUFA4/COX6C/VDAC1	2.30356707669409
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/111	196/9376	2.5857694429123	CXCL1/ZFP36/CXCL8/CALM2/MAP1LC3B/IFNGR1	2.45567650891924
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/111	308/9376	2.19398619398619	SOD2/ATP5MC3/NDUFB3/PSMA3/PSMA5/NDUFA4/COX6C/VDAC1	2.33207934993184
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/111	101/9376	3.34528587993935	F3/CDC42/CXCL8/VCAM1	2.59372502565717
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/111	59/9376	4.29500687127806	GADD45A/GADD45G/PTEN	2.77887299565594
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/111	157/9376	2.69007861364549	CDC42/NDUFB3/CXCL8/NDUFA4/COX6C	2.3374333742824
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/111	212/9376	2.39061703212647	ACTG1/RAP1B/CDC42/CALM2/ID1/RALA	2.24159603755788
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	9/111	388/9376	1.95932014488716	ATP5MC3/DKK1/NDUFB3/CALM2/PSMA3/PSMA5/NDUFA4/COX6C/VDAC1	2.11238128467317
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/111	112/9376	3.01673101673102	HSPA1A/HSPA1B/HSPA8/IFNGR1	2.35007721354811
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/111	67/9376	3.78217022993142	LDHA/LDHB/ADH5	2.50146252606705
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/111	67/9376	3.78217022993142	RAP1B/CALM2/PPP1CB	2.50146252606705
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/111	170/9376	2.48436671966084	ACTG1/MYL12B/CDC42/MYL12A/ACTR3	2.13773860344979
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/111	170/9376	2.48436671966084	ACTG1/GADD45A/MGST1/GADD45G/PTEN	2.13773860344979
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/111	71/9376	3.56909021697754	LDHA/LDHB/PTEN	2.37834447227265
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/111	120/9376	2.81561561561562	RAP1B/CDC42/CALM2/RIPK2	2.19092381022345
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/111	173/9376	2.44128521585169	ACTG1/CXCL8/MX1/IFNGR1/VDAC1	2.09427007984553
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/111	32/9376	5.27927927927928	LDHA/LDHB	2.65401651428477
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/111	73/9376	3.47130692336172	GADD45A/GADD45G/PTEN	2.32006964095681
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/111	75/9376	3.37873873873874	GADD45A/GADD45G/PTEN	2.26379434425301
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/111	235/9376	2.15664174813111	ACTG1/ATP5MC3/NDUFB3/RHEB/NDUFA4/COX6C	1.96544256055085
NA	NA	hsa04517	IgSF CAM signaling	7/111	299/9376	1.97752267317485	ACTG1/DYNLL1/MYL12B/RAP1B/CDC42/MYL12A/ACTR3	1.88025036494822
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/111	78/9376	3.24878724878725	ACTG1/CDC42/ACTR3	2.18285715293437
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/111	37/9376	4.56586316045775	COMT/ADH5	2.37870049672957
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/111	37/9376	4.56586316045775	GADD45A/GADD45G	2.37870049672957
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/111	133/9376	2.54040506672086	SOD2/GADD45A/GADD45G/PTEN	1.958297629344
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/111	82/9376	3.09030982201714	HSPA1A/HSPA1B/HSPA8	2.08084949358793
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/111	136/9376	2.48436671966084	HSPA1A/HSPA1B/HSPA8/MX1	1.9085304483647
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/111	137/9376	2.46623265601368	ACTG1/GADD45A/GADD45G/CTSK	1.89223514153837
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/111	194/9376	2.17702238320795	ACTG1/DYNLL1/MYL12B/MYL12A/DYNLT3	1.81318183005847
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/111	138/9376	2.44836140488314	CALM2/RHOQ/RHEB/PPP1CB	1.87608246147502
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/111	138/9376	2.44836140488314	ACTG1/CDC42/CXCL8/ACTR3	1.87608246147502
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/111	87/9376	2.91270580925753	GADD45A/GADD45G/RALA	1.96176841294681
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/111	142/9376	2.37939347798503	SKP1/UBE2B/UBE2D1/UBE2N	1.81284979203051
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/111	42/9376	4.02230802230802	FTH1/MAP1LC3B	2.14859166484318
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/111	204/9376	2.07030559971736	ACTG1/DCN/CDC42/PPP1CB/TWIST1	1.69166854492105
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	7/111	333/9376	1.77561345128913	SPP1/ISG15/CDC42/ATP6V1G1/MX1/RHEB/PTEN	1.57737734659306
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/111	46/9376	3.67254210732472	PSMA3/PSMA5	1.98878147608332
NA	NA	hsa04518	Integrin signaling	4/111	154/9376	2.19398619398619	SPP1/ACTG1/CDC42/VCAM1	1.63520242433282
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/111	154/9376	2.19398619398619	ACTG1/RGS2/CALM2/PPP1CB	1.63520242433282
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/111	98/9376	2.5857694429123	CDC42/ACTR3/MARCKSL1	1.72723056420285
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/111	155/9376	2.17983144434757	ACTG1/SEC61G/SEC61B/ATP6V1G1	1.62114260832288
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/111	158/9376	2.13844223970806	ATP6V1G1/RHEB/DDIT4/PTEN	1.57959448359737
Genetic Information Processing	Translation	hsa03010	Ribosome	5/111	222/9376	1.90244298352406	MRPL18/RPS7/RPL22L1/RPL26L1/RPS10	1.4894132792953
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/111	107/9376	2.36827481687295	LDHA/CALM2/LDHB	1.55802060641875
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/111	166/9376	2.03538478237273	RGS2/CALM2/PPP1CB/VDAC1	1.47316171013925
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/111	54/9376	3.12846179512846	LDHA/LDHB	1.71685099926723
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/111	168/9376	2.01115401115401	FTH1/GLUL/IFNGR1/VDAC1	1.4474837948243
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/111	109/9376	2.32482023307711	SPP1/CTSK/CXCL8	1.52273747297645
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/111	169/9376	1.99925369156138	MAP1LC3B/RHEB/DDIT4/PTEN	1.43477717078034
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/111	110/9376	2.3036855036855	LDHA/LDHB/IFNGR1	1.5053845234632
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/111	243/9376	1.73803433062692	HSPA1A/HSPA1B/HSPA8/SRSF7/SF3B6	1.27584344838377
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/111	180/9376	1.87707707707708	SRSF7/RHEB/PPP1CB/IFNGR1	1.30046583637095
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/111	119/9376	2.12945718828072	CXCL1/CEBPB/VCAM1	1.35716464780125
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/111	181/9376	1.86670648549102	CEBPB/CALM2/IFNGR1/RIPK2	1.28872389996013
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/111	63/9376	2.68153868153868	GADD45A/GADD45G	1.46573936295606
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/111	17/9376	4.96873343932167	SCP2	1.79261110806839
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/111	17/9376	4.96873343932167	GLUL	1.79261110806839
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/111	125/9376	2.02724324324324	SPTSSA/CERS2/PTEN	1.26548900186391
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/111	68/9376	2.48436671966084	ALDH1A1/ADH5	1.3445962431007
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/111	193/9376	1.75064183354339	CXCL1/RAP1B/CDC42/CXCL8	1.15330332006539
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/111	69/9376	2.44836140488314	CALM2/PPP1CB	1.32166396033474
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/111	70/9376	2.41338481338481	RAP1B/CDC42	1.29912916381766
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/111	133/9376	1.90530380004064	COMT/CALM2/PPP1CB	1.1509013594909
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/111	72/9376	2.34634634634635	ISG15/CXCL8	1.25519907124676
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/111	200/9376	1.68936936936937	ACTG1/CDC42/CXCL8/ACTR3	1.07861062418023
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/111	73/9376	2.31420461557448	MGST1/ADH5	1.23377885675651
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/111	73/9376	2.31420461557448	GADD45A/GADD45G	1.23377885675651
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/111	201/9376	1.68096454663619	GADD45A/GADD45G/CEBPB/CXCL8	1.06817869008479
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/111	21/9376	4.02230802230802	CHST7	1.51757754254186
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/111	138/9376	1.83627105366236	SKP1/CALM2/PPP1CB	1.08323340536803
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/111	205/9376	1.64816523840914	VIM/GADD45A/ISG15/GADD45G	1.02701960815163
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/111	76/9376	2.22285443338075	ACTG1/CALM2	1.17155990469051
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/111	140/9376	1.81003861003861	SPP1/CALM2/MAP1LC3B	1.05694451969284
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/111	77/9376	2.19398619398619	GADD45A/GADD45G	1.15146557780704
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/111	78/9376	2.16585816585817	CXCL8/CALM2	1.13167745771544
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/111	78/9376	2.16585816585817	MARCKSL1/IFNGR1	1.13167745771544
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/111	23/9376	3.67254210732472	GLUL	1.40455070824575
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/111	79/9376	2.13844223970806	MGST1/ADH5	1.11218631502715
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/111	144/9376	1.75975975975976	CXCL1/CXCL8/ADH5	1.00562034609127
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/111	144/9376	1.75975975975976	PSMA3/PSMA5/VDAC1	1.00562034609127
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/111	148/9376	1.71219868517166	GADD45A/GADD45G/PTEN	0.955878400319275
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/111	83/9376	2.03538478237273	SKP1/UBE2D1	1.03702033123166
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/111	83/9376	2.03538478237273	SOD2/SCP2	1.03702033123166
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/111	149/9376	1.70070741882822	CXCL8/RHEB/RALA	0.943678380015205
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/111	27/9376	3.12846179512846	SCP2	1.2122426989969
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/111	28/9376	3.01673101673102	ATP6V1G1	1.16974731565862
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/111	157/9376	1.6140471681873	ACTG1/PPP1CB/ID1	0.849247089878654
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/111	158/9376	1.60383167978105	SKP1/GADD45A/GADD45G	0.837819572337782
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/111	90/9376	1.87707707707708	SOD2/RHEB	0.915101129584572
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/111	90/9376	1.87707707707708	IFNGR1/PTEN	0.915101129584572
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/111	29/9376	2.91270580925753	CALM2	1.1291079630349
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/111	233/9376	1.450102462978	VIM/ACTG1/DCN/PDLIM1	0.761499120036624
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/111	93/9376	1.81652620362298	CDC42/CALM2	0.866147470309966
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/111	31/9376	2.72478930543447	GLUL	1.05281402199005
NA	NA	hsa04981	Folate transport and metabolism	1/111	31/9376	2.72478930543447	MTHFS	1.05281402199005
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/111	238/9376	1.41963812552048	RAP1B/CDC42/CALM2/RALA	0.717731911109723
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/111	98/9376	1.72384629527487	CALM2/PTEN	0.788418171741056
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/111	99/9376	1.70643370643371	CALM2/PPP1CB	0.773409758609384
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/111	99/9376	1.70643370643371	CHPT1/RHEB	0.773409758609384
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/111	100/9376	1.68936936936937	CXCL1/CXCL8	0.758570637824286
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/111	34/9376	2.48436671966084	SKP1	0.949041385612361
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/111	102/9376	1.65624447977389	RAP1B/RAB27B	0.729384649650365
NA	NA	hsa04519	Cadherin signaling	6/111	404/9376	1.25448220497725	VIM/ACTG1/CDC42/KRT10/PPP1CB/ACTR3	0.572305454333004
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/111	103/9376	1.64016443628094	CXCL8/IFNGR1	0.715030293602883
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/111	103/9376	1.64016443628094	CXCL1/CXCL8	0.715030293602883
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/111	178/9376	1.42362587306408	SKP1/DKK1/BAMBI	0.624554283341703
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/111	37/9376	2.28293158022888	GLUL	0.855812421800485
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/111	38/9376	2.22285443338075	NNMT	0.826730655381106
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/111	109/9376	1.54988015538474	PPP1CB/PTEN	0.632027725230042
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/111	39/9376	2.16585816585817	MTHFS	0.798543830679435
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/111	184/9376	1.37720329024677	MYL12B/CDC42/MYL12A	0.56559269516048
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/111	41/9376	2.06020654801143	CXCL8	0.744645664278086
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/111	43/9376	1.9643829876388	ADH5	0.693741302172563
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/111	44/9376	1.91973791973792	DYNLL1	0.669310258177006
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/111	46/9376	1.83627105366236	FTH1	0.622314004314508
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/111	122/9376	1.38472899128637	ACTG1/RHEB	0.468160207957232
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/111	51/9376	1.65624447977389	CHPT1	0.514340528507965
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/111	52/9376	1.62439362439362	VDAC1	0.494178008683566
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/111	134/9376	1.26072340997714	CALM2/PPP1CB	0.332716133504283
NA	NA	hsa04382	Cornified envelope formation	3/111	217/9376	1.1677668451862	KRT10/S100A9/ABHD5	0.273675796669543
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/111	55/9376	1.53579033579034	CERS2	0.436183650007911
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/111	56/9376	1.50836550836551	GAS1	0.417625058919454
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/111	57/9376	1.48190295558717	SCP2	0.399426410631817
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/111	224/9376	1.13127413127413	ZFP36/PTEN/VDAC1	0.217655463025649
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/111	226/9376	1.12126285577613	RAP1B/CALM2/PPP1CB	0.201974192317341
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/111	142/9376	1.18969673899251	CTSK/IFNGR1	0.24930645194422
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/111	59/9376	1.43166895709269	MGST1	0.364051807716731
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/111	59/9376	1.43166895709269	ABHD5	0.364051807716731
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/111	227/9376	1.11632337182998	CXCL8/CALM2/RHEB	0.194185819870357
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/111	144/9376	1.17317317317317	ID4/ID1	0.229212542653214
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/111	60/9376	1.40780780780781	CDC42	0.34684931206521
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/111	61/9376	1.38472899128637	FTH1	0.329953559235737
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/111	63/9376	1.34076934076934	PTGES3	0.297036899559851
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/111	149/9376	1.13380494588548	NDUFB3/NDUFA4	0.18020193761098
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/111	150/9376	1.12624624624625	GADD45A/GADD45G	0.170601087008293
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/111	65/9376	1.2995148995149	SPP1	0.265217002434432
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/111	66/9376	1.27982527982528	COMT	0.249694220281842
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/111	66/9376	1.27982527982528	IFNGR1	0.249694220281842
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/111	154/9376	1.0969930969931	CALM2/PPP1CB	0.13283516019323
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/111	156/9376	1.08292908292908	IFIT1/MX1	0.114321553444675
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/111	69/9376	1.22418070244157	CALM2	0.204570181185861
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/111	70/9376	1.20669240669241	MGST1	0.189983740401672
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/111	70/9376	1.20669240669241	ACTG1	0.189983740401672
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/111	73/9376	1.15710230778724	MX1	0.147488072556206
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/111	75/9376	1.12624624624625	GLUL	0.120145829208197
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/111	75/9376	1.12624624624625	MGST1	0.120145829208197
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/111	76/9376	1.11142721669037	SCP2	0.10675322900437
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/111	78/9376	1.08292908292908	PTEN	0.0804977624965013
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/111	78/9376	1.08292908292908	EXOSC3	0.0804977624965013
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/111	79/9376	1.06922111985403	ATP6V1G1	0.0676246712632959
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/111	80/9376	1.05585585585586	PTEN	0.0549148829755665
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/111	82/9376	1.03010327400571	MGST1	0.0299670325472035
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/111	362/9376	0.933353242745508	SPP1/RHEB/DDIT4/PTEN	-0.141546438864865
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/111	183/9376	0.923152660857579	NOP10/REXO2	-0.114907973382244
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/111	86/9376	0.982191493819401	ACTG1	-0.0181590563261721
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/111	87/9376	0.970901936419178	COX6C	-0.0298444547689921
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/111	88/9376	0.95986895986896	F3	-0.0413985437564667
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/111	89/9376	0.94908391537605	SPP1	-0.0528246582354572
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/111	89/9376	0.94908391537605	GLUL	-0.0528246582354572
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/111	191/9376	0.884486580821659	CALM2/PPP1CB	-0.176536274850702
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/111	93/9376	0.908263101811489	IFNGR1	-0.0973118583916879
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/111	93/9376	0.908263101811489	CALM2	-0.0973118583916879
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/111	195/9376	0.866343266343266	ACTG1/VDAC1	-0.206437015255788
NA	NA	hsa04082	Neuroactive ligand signaling	2/111	199/9376	0.848929331341392	P2RY14/OGFRL1	-0.235765763444253
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/111	97/9376	0.87080895328318	CALM2	-0.139988420206921
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/111	298/9376	0.850353709414112	CXCL1/CXCL8/IFNGR1	-0.28734484792782
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/111	98/9376	0.861923147637433	CALM2	-0.150394220720735
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/111	99/9376	0.853216853216853	KRT10	-0.160699464206742
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/111	99/9376	0.853216853216853	ACTG1	-0.160699464206742
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/111	101/9376	0.836321469984836	CALM2	-0.181017206940285
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/111	103/9376	0.82008221814047	PPP1CB	-0.200958780426442
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/111	104/9376	0.812196812196812	CHPT1	-0.210793557670456
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/111	105/9376	0.804461604461605	MAP1LC3B	-0.220540229454003
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/111	105/9376	0.804461604461605	CALM2	-0.220540229454003
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/111	105/9376	0.804461604461605	ACTG1	-0.220540229454003
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/111	106/9376	0.796872344042155	PTEN	-0.230200646100331
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/111	214/9376	0.789424938957649	SKP1/CALM2	-0.341069664482688
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/111	108/9376	0.782115448782115	SUMO2	-0.249269831019581
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/111	109/9376	0.774940077692371	IFNGR1	-0.258682022516369
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/111	217/9376	0.778511230124133	MGST1/PTGES3	-0.361311649401636
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/111	323/9376	0.784536858840264	VIM/DDIT4/PTEN	-0.431322787970297
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/111	115/9376	0.734508421464943	DUSP1	-0.313541580742688
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/111	116/9376	0.728176452314383	ADH5	-0.322429665987578
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/111	116/9376	0.728176452314383	GLUL	-0.322429665987578
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/111	117/9376	0.721952721952722	ACTG1	-0.331248524529552
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/111	122/9376	0.692364495643184	RHEB	-0.374348450355054
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/111	122/9376	0.692364495643184	CDC42	-0.374348450355054
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/111	133/9376	0.635101266680214	IFNGR1	-0.4638911802153
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/111	250/9376	0.675747747747748	ATP6V1G1/CTSK	-0.568770665250736
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/111	254/9376	0.665106050932823	CALM2/VDAC1	-0.592247915465958
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/111	155/9376	0.544957861086893	RAP1B	-0.625248804402181
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/111	157/9376	0.538015722729099	CEBPB	-0.638939194525096
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/111	160/9376	0.527927927927928	VCAM1	-0.659206501897248
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/111	163/9376	0.518211462996739	CXCL8	-0.679163198845336
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/111	168/9376	0.502788502788503	IFNGR1	-0.711766532966212
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/111	205/9376	0.412041309602285	CDC42	-0.931622166754399
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/111	370/9376	0.456586316045776	P2RY14/OGFRL1	-1.16731986670769
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/111	449/9376	0.376251529926363	RGS2/CALM2	-1.48253280571637