category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	77/1963	142/9376	2.58999949775064	BIRC2/SOCS3/UBE2B/UBE2H/HERC4/CUL5/SIAH1/RCHY1/TRIP12/CUL2/CUL4B/UBE2W/TRAF6/UBE2N/CUL3/BTRC/UBE2S/UBE2L6/MAP3K1/CDC23/UBE2D3/UBA6/UBE2A/CDC16/UBE2E3/SOCS1/VHL/UBE2Q1/ANAPC10/CDC26/MDM2/UBE2J2/PML/SKP1/FANCL/CUL1/UBE2D1/UBE2J1/KLHL9/BIRC6/MID1/CDC27/UBE2Z/UBE4A/PIAS1/UBE2G1/COP1/UBE3A/ANAPC16/UBE2D2/PIAS2/SKP2/UBA2/ANAPC5/ANAPC7/ANAPC13/UBE2R2/FBXO2/RNF7/UBE2E1/UBE2I/UBB/ANAPC1/UBA3/HUWE1/BIRC3/NEDD4/UBE4B/WWP1/DDB2/ELOC/UBE3C/TRIM37/SYVN1/SAE1/ANAPC4/UBC	9.82415061725595
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	79/1963	174/9376	2.16857847184406	HSPA1A/HSPA1B/DNAJA1/HSPH1/HSP90AA1/HSP90AB1/HSPA8/MAN1A1/HSPA5/DNAJB1/DDIT3/CALR/PPP1R15A/HERPUD1/XBP1/DNAJB11/HSPA4L/HSPA6/PDIA6/BCAP29/ERO1B/EIF2S1/STT3B/DNAJC3/DNAJA2/PDIA4/SAR1B/PDIA3/ATXN3/HYOU1/UBE2D3/UBQLN2/UBXN2A/HSP90B1/MBTPS1/DERL1/TRAM1/CAPN2/CANX/UBE2J2/SKP1/TUSC3/WFS1/CUL1/UBE2D1/UBE2J1/OSTC/DNAJB2/DDOST/UBQLN1/DERL2/DNAJB12/UFD1/UBE2G1/UBE2D2/EDEM3/SEC24A/SEC23A/DNAJC10/MAPK8/UBXN1/OS9/RAD23B/ERO1A/VCP/FBXO2/YOD1/UGGT1/TRAF2/EDEM2/SEC24B/UBE4B/ATF6B/FBXO6/SEC61B/DAD1/SYVN1/MAN1C1/UBXN8	8.00645337420242
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	68/1963	158/9376	2.05564977398325	CDKN1B/GADD45A/PPP2R5A/CDC25B/STAG1/MYC/CDK2/STAG2/SMAD4/CDKN2C/CDC14A/RB1/BUB3/CDC23/TGFB3/PPP2R5C/ATM/CDC16/CCND3/ANAPC10/CDC26/MDM2/PPP2CB/RBL2/GADD45B/ESCO1/SKP1/YWHAG/CUL1/CCNH/MCM3/CDC27/WAPL/EP300/PRKDC/PPP2CA/ANAPC16/ORC4/YWHAQ/SKP2/ANAPC5/ANAPC7/RAD21/ANAPC13/HDAC8/ATR/PCNA/CDC14B/TFDP1/ANAPC1/PPP2R1B/FBXO5/NIPBL/YWHAZ/GSK3B/CDKN2D/MAD2L1BP/CHEK1/CDKN1A/WEE1/ORC2/MCM6/CCNB1/ANAPC4/PPP2R5B/CDK1/ORC1/RBL1	6.88618741906076
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	94/1963	248/9376	1.81039554335859	HSP90AA1/HSP90AB1/FOS/NFKBIA/MLKL/RHOB/BIRC2/CASP7/JUN/CASP3/LY96/EXOC5/DYNLL1/CASP4/KPNA4/MYC/PIK3CA/CYFIP1/CDC42/RAB5A/NAIP/TRAF6/CYCS/DYNC1I1/TNFRSF10B/PIK3C2A/CTNNB1/WASL/DYNLT3/ARPC5L/RIPK2/NCKAP1/ARF6/ACBD3/TLR5/RILP/TNFRSF1A/WASF3/M6PR/ARPC1B/HSP90B1/ARPC1A/MAP2K6/KPNA3/IRAK4/ABI1/SKP1/MYL12A/PYCARD/ARL8B/IKBKB/TNFSF10/MYO6/ACTR2/PLEKHM1/NFKB1/RIPK1/PIK3C3/CASP1/PIK3C2B/S100A10/AKT3/ACTR10/EXOC2/MYL12B/MAPK8/DYNC1H1/TRADD/TCF7/MAP3K7/CXCL8/ACTR3/STX10/MAPK1/TRAF2/DYNLT1/DYNC1LI2/AKT1/RAB7A/BRK1/BIRC3/CYTH2/PIK3CB/ARF1/FBXO22/PIK3CG/NOD1/PODXL/CSE1L/DYNC2H1/ACTR3C/GCC2/ARPC3/DYNLRB1	6.65554856311286
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	85/1963	224/9376	1.81245906411469	FOS/ZFP36/CALR/NFKBIA/TBPL1/TGFBR2/ETS2/JUN/NFYB/ATF2/XPO1/ELK4/MYC/PIK3CA/CDK2/PTEN/SMAD4/CDKN2C/KAT2B/RB1/B2M/ADCY4/BUB3/MAP3K1/CDC23/TGFB3/PPP3R1/ATM/NFATC1/CDC16/CCND3/TNFRSF1A/PPP3CC/VDAC3/PPP3CA/ANAPC10/CDC26/CANX/CREB1/SLC25A5/KRAS/IKBKB/CDC27/RANBP3/EP300/NFKB1/TRRAP/NFATC3/HLA-F/ANAPC16/CREB5/AKT3/ANAPC5/ANAPC7/MAPK8/ANAPC13/RAN/DLG1/ETS1/ATR/IL15RA/MAPK1/ANAPC1/POLB/RANBP1/FOSL1/NFKB2/AKT1/ICAM1/VDAC2/MSX1/KAT2A/PIK3CB/ELK1/JAK1/VDAC1/CRTC3/ATF6B/CHEK1/CRTC2/CDKN1A/ADCY6/ANAPC4/PIK3R3/EGR1	6.33309903709632
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	47/1963	108/9376	2.07860229052282	IPO11/DDX39B/SUMO1/XPO1/KPNA4/AHCTF1/NUP54/NMD3/EIF4A3/NXT1/UPF1/THOC1/NUP58/NUP98/KPNA3/NUP153/KPNA5/MAGOH/TNPO1/TMEM33/PNN/NCBP1/IPO7/IPO5/THOC7/RANBP2/SENP2/RAN/SUMO2/NXF1/XPO4/UBE2I/SUMO4/THOC3/NUP107/UPF3A/NUP133/UPF3B/CSE1L/THOC5/SAP18/THOC6/NUP205/PYM1/NUP35/TNPO2/NUP88	5.80134898158584
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	39/1963	83/9376	2.24431500837788	USP45/AUTS2/OGT/MGA/KDM2A/UBE2D3/L3MBTL3/PHC3/MAX/MTF2/E2F6/ASXL1/SKP1/ASXL2/UBE2D1/SUZ12/AEBP2/EP300/LCOR/PHC2/BCOR/USP7/UBE2D2/MBD5/RNF2/PCGF3/EED/FBRS/PHF1/PCGF5/TFDP1/EZH2/SCML1/SCML2/L3MBTL4/BMI1/CBX7/PHC1/FOXK1	5.85922539547505
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	70/1963	187/9376	1.78794326047929	HSP90AA1/HSP90AB1/OAS1/TXNIP/CARD6/OAS2/NFKBIA/CXCL2/BIRC2/CXCL1/IRF7/TBK1/JUN/SUGT1/CASP4/ANTXR2/GBP4/MAP1LC3B/NAIP/PLCB1/CARD8/TRAF6/STAT1/IRF9/DNM1L/TANK/RIPK2/MFN1/IFI16/OAS3/TRPM7/CARD16/GABARAPL2/ERBIN/GBP2/ATG5/NEK7/VDAC3/PLCB4/ATG12/GBP1/IRAK4/TP53BP1/NAMPT/PYCARD/IFNAR1/GBP3/IKBKB/PANX1/NFKB1/RIPK1/CASP1/PKN2/MAPK8/SHARPIN/MAP3K7/RBCK1/CXCL8/MAPK1/ITPR1/TRAF2/CXCL3/VDAC2/BIRC3/GBP7/ATG16L1/JAK1/VDAC1/NOD1/PLCB3	5.6005465417584
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	61/1963	157/9376	1.85578423769675	PPID/GADD45A/TGFBR2/HIPK3/SIRT1/MYC/PIK3CA/CDK2/PTEN/PPP1CC/RB1/HUS1/BTRC/TGFB3/PPP3R1/TRPM7/ATM/NFATC1/CCND3/PPP3CC/VDAC3/PPP3CA/CAPN2/MAP2K6/MDM2/RBL2/GADD45B/MRE11/SLC25A5/KRAS/HIPK1/NBN/NFKB1/PPP1CB/NFATC3/HLA-F/AKT3/ETS1/ATR/RAD50/CXCL8/LIN9/MAPK1/ITPR1/ZFP36L1/AKT1/VDAC2/PIK3CB/VDAC1/CALM1/CHEK1/CDKN1A/TRAF3IP2/RAD1/LIN54/ZFP36L2/CCNB1/PIK3R3/CDK1/RAD9A/RBL1	5.56443392582029
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	29/1963	56/9376	2.47347354632123	HSPA1A/HSPA1B/HSPA8/HSPD1/NFKBIA/CXCL2/CASP7/CXCL1/CLK4/CLK1/HSPA6/CASP3/HBS1L/SEC22B/NAIP/CYCS/SAR1B/TLR5/PYCARD/NFKB1/RAB1A/CASP1/VCP/APAF1/CXCL8/NFKB2/CXCL3/ARF1/IL12A	5.69085065427411
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	77/1963	216/9376	1.70268485500274	HSPA1A/HSPA1B/HSP90AA1/HSP90AB1/HSPA8/HSPD1/HSPA5/HSPA4/VAV3/FOS/DDIT3/CD36/NFKBIA/CXCL2/XBP1/CASP7/CXCL1/IRF7/TBK1/JUN/HSPA6/CASP3/SOD2/LY96/STAT3/CAMK2D/PRKCA/PIK3CA/EIF2S1/CDC42/PLCB1/TRAF6/CYCS/TNFRSF10B/PTK2/TANK/BID/PPP3R1/NFATC1/PPARG/TNFRSF1A/HSP90B1/PPP3CC/PPP3CA/ABCG1/PLCB4/MAP2K6/IRAK4/RAP1A/PYCARD/KRAS/IKBKB/TNFSF10/NFKB1/NFATC3/CASP1/AKT3/MAPK8/ERO1A/MAP3K7/APAF1/CXCL8/MAPK1/ITPR1/TRAF2/AKT1/ICAM1/CXCL3/PIK3CB/GSK3B/CALM1/RAP1B/JAK2/PLCB3/PIK3R3/IL12A/VLDLR	5.37636221171329
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	63/1963	169/9376	1.7805375783353	CALCOCO2/VMP1/TBK1/NRBF2/RAB33B/RAB8A/PIK3CA/MAP1LC3B/PTEN/EIF2S1/TRAF6/TANK/ATG4C/SUPT20H/STX7/GABARAPL2/LAMP2/ATG5/STX17/NBR1/PIK3R4/PPP2CB/DAPK1/ATG12/BIRC6/PRKAA1/KRAS/ATG3/ATG101/RRAGB/PLEKHM1/SH3GLB1/PPP2CA/RAB1A/PRKAA2/PIK3C3/MTMR4/AKT3/ZFYVE1/CAMKK2/MAPK8/HIF1A/MAP3K7/ATG2B/IGBP1/MAPK1/ITPR1/UBB/C9orf72/AKT1/RAB7A/ATG10/PIK3CB/ATG16L1/MTMR3/STK11/DAPK2/OPTN/PIK3R3/UBC/ATG9A/SMCR8/AKT1S1	5.26898406722038
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	66/1963	180/9376	1.7513329937171	OAS1/OAS2/CALR/NFKBIA/SRSF7/EIF2AK2/BIRC2/SRSF1/ZC3HAV1/IRF7/IFNGR1/TBK1/SOCS3/CASP3/SRSF2/SRSF3/SP100/SRSF6/SRSF5/PIK3CA/IFNGR2/PPP1CC/EIF2S1/TRAF6/CYCS/STAT1/IRF9/B2M/TAP1/SRSF9/BID/PDIA3/IFIH1/OAS3/PILRB/EIF2B2/TNFRSF1A/CGAS/PML/SRSF8/IRAK4/SRSF4/IFNAR1/IKBKB/PTPN11/NFKB1/PPP1CB/HLA-F/AKT3/TAP2/SRPK1/TRADD/EIF2B5/MAP3K7/APAF1/NXF1/TRAF2/AKT1/BIRC3/PIK3CB/JAK1/JAK2/TLR3/BST2/PIK3R3/IL12A	5.2374274475928
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	86/1963	253/9376	1.62358574336691	PPID/TIFA/CALCOCO2/NFKBIA/FNBP1L/TBK1/JUN/CASP4/BCL10/PIK3CA/MAP1LC3B/CDC42/NAIP/PLCB1/TRAF6/CYCS/UBE2N/DOCK1/PTK2/WASL/ARPC5L/BTRC/RIPK2/ARF6/UBE2D3/TECPR1/ATM/TLR5/ATG5/TNFRSF1A/ARPC1B/PIK3R4/ARPC1A/PLCB4/CAPN2/CGAS/MDM2/ATG12/SKP1/CUL1/MYL12A/UBE2D1/PYCARD/IKBKB/CRK/ACTR2/RRAGB/NFKB1/RIPK1/UBE2D2/PIK3C3/CASP1/AKT3/MYL12B/MAPK8/SHARPIN/TRADD/MAP3K7/RBCK1/CXCL8/ACTR3/MAPK1/ITPR1/UBB/TRAF2/PLCE1/AKT1/HCLS1/CYTH2/PIK3CB/ARF1/ATG16L1/GSK3B/VDAC1/MALT1/ARHGEF2/NOD1/ACTR3C/PLCB3/ARPC3/PIK3R3/UBC/GLMN/WASF1/ACTN1/AKT1S1	5.1741187124438
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	43/1963	103/9376	1.99401550034868	DDX39B/PPP2R5A/PAPOLA/HBS1L/PPP1CC/PPP2R3C/CSTF2T/ETF1/PCF11/WDR33/EIF4A3/PELO/NXT1/CPSF6/UPF1/RNGTT/PPP2R5C/PAPOLG/SMG1/NUDT21/PPP2CB/PPP2R2D/PABPN1/MAGOH/PPP1CB/PPP2CA/PNN/SMG7/NCBP1/CSTF1/FIP1L1/CPSF7/RNMT/NXF1/PPP2R1B/UPF3A/FUS/DAZAP1/UPF3B/SAP18/PPP2R5B/GSPT2/PYM1	5.21975870332207
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	84/1963	250/9376	1.60485787060622	HSPA1A/HSPA1B/HSPA8/SNX3/PARD6G/TGFBR2/VPS26A/HSPA6/SPART/SNX2/EPS15/ARF4/ZFYVE16/SNX1/STAM2/RAB8A/CHMP5/ARFGEF1/CDC42/RAB5A/TRAF6/RUFY2/RAB10/WASL/RUFY1/ARPC5L/RAB11A/CAPZA2/ARF6/PDCD6IP/ARFGAP2/ARPC1B/RAB22A/ARPC1A/RAB11FIP3/MDM2/ZFYVE9/PML/EPS15L1/STAMBP/CHMP7/VPS36/CLTC/WASHC4/ACTR2/CHMP4B/VPS37A/SH3GLB1/SNX4/HLA-F/RAB35/WASHC2A/EHD1/PLD1/ARAP3/TSG101/ACTR3/ACAP2/RAB11FIP5/VPS37B/WASHC5/SNX5/RAB7A/SNX6/WASHC3/ARFGEF2/ARFGAP3/NEDD4/CYTH2/CHMP1B/WWP1/STAM/VPS29/ARF1/ASAP2/AP2M1/ASAP1/ARAP2/ACTR3C/VPS26B/CLTA/ARPC3/ARFGAP1/EHD3	4.98806261191681
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	69/1963	196/9376	1.68147462754842	FOS/ZFP36/CLEC2B/NFKBIA/CXCL2/EIF2AK2/CXCL1/IRF7/IFNGR1/TBK1/JUN/CASP3/STAT3/GNB4/MYC/PIK3CA/MAP1LC3B/CYCS/STAT1/IRF9/CTNNB1/RB1/BID/GNG12/PPP3R1/NFATC1/TNFRSF1A/PPP3CC/PPP3CA/MAP2K6/CREB1/IFNAR1/IL6ST/KRAS/ATG3/IKBKB/EP300/NFKB1/MICB/NFATC3/HLA-F/PIK3C3/AKT3/MAPK8/HIF1A/TRADD/TCF7/CXCL8/MAPK1/ITPR1/UBB/TRAF2/GNGT2/AKT1/ICAM1/CXCL3/PIK3CB/JAK1/GSK3B/CALM1/GNG11/CDKN1A/PIK3CG/GNG10/GNG5/JAK2/TLR3/PIK3R3/UBC	4.96141064331282
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/1963	133/9376	1.83153758057906	KLF2/CDKN1B/IGF1/GADD45A/TGFBR2/SOS2/SOD2/DEPP1/SIRT1/STAT3/BCL2L11/HOMER3/PIK3CA/CDK2/PTEN/SOS1/SMAD4/SGK3/CCNG2/BRAF/PLK3/TGFB3/GABARAPL2/ATM/MDM2/RBL2/ATG12/GADD45B/BCL6/PLK2/S1PR1/PRKAA1/KRAS/IKBKB/TNFSF10/EP300/USP7/PRKAA2/AKT3/SKP2/MAPK8/PRKAG2/MAPK1/AKT1/PIK3CB/RAG1/CDKN2D/CDKN1A/STK11/CCNB1/PIK3R3	4.96992704269988
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	39/1963	93/9376	2.00299081392865	CDKN1B/NFKBIA/GADD45A/ITGA2/CKS2/BIRC2/CASP3/POLK/MYC/PIK3CA/CDK2/PTEN/TRAF6/CYCS/PTK2/RB1/LAMB1/ITGAV/COL4A1/MAX/GADD45B/ITGA6/IKBKB/NFKB1/AKT3/SKP2/COL4A5/CKS1B/APAF1/TRAF2/AKT1/BIRC3/PIK3CB/DDB2/LAMC2/CDKN1A/PIK3R3/FHIT/RARB	5.00199257199902
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	59/1963	163/9376	1.72886748403752	FOS/DDX3X/NFKBIA/TGFBR2/IRF7/TBK1/JUN/SOS2/ATF2/CASP3/STAT3/MYC/PRKCA/PIK3CA/CDK2/SOS1/SMAD4/CASP10/TRAF6/CYCS/STAT1/EGR3/RB1/BID/BRAF/IFIH1/MAP3K1/TGFB3/NFATC1/VDAC3/MAP2K6/CREB1/IRAK4/IFNAR1/KRAS/IKBKB/EP300/NFKB1/NFATC3/CREB5/YWHAQ/AKT3/MAPK8/MAP3K7/APAF1/PCNA/CXCL8/MAPK1/AKT1/PIK3CB/DDB2/YWHAZ/ELK1/JAK1/ATF6B/CDKN1A/JAK2/TLR3/PIK3R3	4.83048380760808
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	34/1963	78/9376	2.08200425826508	ITPKC/PIK3CA/PTEN/PLCB1/PPIP5K2/IMPA1/MTMR6/PIK3C2A/MTMR2/INPP4B/IPMK/PIP4K2A/PLCB4/IP6K1/PIK3C3/MTMR4/PIK3C2B/SACM1L/SYNJ1/PLCE1/PI4KB/PIK3CB/MTM1/MINPP1/MTMR3/PIK3CG/PIKFYVE/IP6K2/ALDH6A1/INPP5F/PLCB3/INPP5K/INPP1/IPPK	4.93776353714858
Human Diseases	Infectious disease: viral	hsa05162	Measles	51/1963	136/9376	1.79113601630158	HSPA1A/HSPA1B/HSPA8/OAS1/MX1/FOS/OAS2/CDKN1B/NFKBIA/EIF2AK2/IRF7/TBK1/JUN/HSPA6/CASP3/CD46/STAT3/MX2/RCHY1/PIK3CA/CDK2/EIF2S1/BBC3/TRAF6/CYCS/STAT1/IRF9/BID/IFIH1/ADAR/OAS3/CCND3/CSNK2A2/IRAK4/IFNAR1/IKBKB/CLEC4M/NFKB1/AKT3/MSN/MAPK8/TRADD/MAP3K7/APAF1/AKT1/PIK3CB/EIF3H/JAK1/GSK3B/PIK3R3/IL12A	4.78226251803847
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	29/1963	63/9376	2.19864315228554	ALDH2/NSD1/NSD3/HADH/SMYD2/ALDH9A1/EHMT2/KMT2E/PHYKPL/SETD2/ALDH3A2/EHMT1/KMT5A/ACAT2/PLOD2/KMT5B/ASH1L/DLST/SETDB2/TMLHE/EZH2/SMYD3/DLD/NSD2/GCDH/KMT2A/CAMKMT/AASS/KMT2B	4.91206573259647
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	61/1963	173/9376	1.6841510134011	OAS1/MX1/DNAJB1/OAS2/CALCOCO2/NFKBIA/EIF2AK2/RSAD2/IRF7/IFNGR1/TBK1/SOCS3/CASP3/XPO1/TRIM25/MX2/PRKCA/PIK3CA/IFNGR2/EIF2S1/CYCS/DNAJC3/STAT1/IRF9/TNFRSF10B/RAB11A/BID/NXT1/IFIH1/ADAR/OAS3/CCND3/TNFRSF1A/NUP98/PML/IRAK4/PYCARD/IFNAR1/PABPN1/SLC25A5/IKBKB/TNFSF10/KPNA5/EP300/NFKB1/CASP1/AKT3/TRADD/APAF1/CXCL8/NXF1/MAPK1/AKT1/ICAM1/PIK3CB/JAK1/VDAC1/JAK2/TLR3/PIK3R3/IL12A	4.67368139381573
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	56/1963	156/9376	1.71459174210066	IFIT1/OAS1/MX1/OAS2/NFKBIA/EIF2AK2/RSAD2/IRF7/TBK1/SOCS3/SOS2/CASP3/STAT3/MX2/MYC/PIK3CA/CDK2/SOS1/EIF2S1/TRAF6/CYCS/STAT1/IRF9/CTNNB1/RB1/BID/BRAF/OAS3/CLDN5/TNFRSF1A/PPP2CB/YWHAG/PPP2R2D/IFNAR1/KRAS/IKBKB/PIAS1/NFKB1/RIPK1/PPP2CA/YWHAQ/AKT3/TRADD/APAF1/MAPK1/TRAF2/PPP2R1B/AKT1/PIK3CB/YWHAZ/JAK1/GSK3B/OCLN/CDKN1A/TLR3/PIK3R3	4.63130752549474
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	36/1963	87/9376	1.97642594902243	FOS/GADD45A/TGFBR2/JUN/SOS2/CASP3/BCL2L11/POLK/MYC/PIK3CA/PMAIP1/SOS1/MSH6/BBC3/SMAD4/RALB/CYCS/CTNNB1/BRAF/TGFB3/GADD45B/KRAS/MSH2/MSH3/RALGDS/AKT3/APC/MAPK8/TCF7/MAPK1/AKT1/PIK3CB/DDB2/GSK3B/CDKN1A/PIK3R3	4.70829044015578
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	39/1963	98/9376	1.90079740505474	PRKCA/ITPKC/PIK3CA/PTEN/PLCB1/PPIP5K2/IMPA1/MTMR6/PIK3C2A/MTMR2/INPP4B/IPMK/PIP4K2A/CDS2/PLCB4/PIP4P2/IP6K1/PIK3C3/MTMR4/PIK3C2B/SACM1L/SYNJ1/DGKE/ITPR1/PLCE1/PI4KB/PIK3CB/DGKH/MTM1/CALM1/MTMR3/PIP4P1/PIKFYVE/IP6K2/INPP5F/PLCB3/PIK3R3/INPP1/IPPK	4.61276965568931
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/1963	78/9376	2.02076883890435	HSPD1/BTG2/C1D/BTG3/DDX6/XRN1/DCP2/TOB1/CNOT10/PATL1/CNOT2/LSM8/CNOT6L/LSM6/CNOT4/BTG1/LSM2/HSPA9/CNOT7/CNOT8/DIS3/EXOSC10/EXOSC8/CNOT6/CNOT1/LSM5/DCP1A/PAN3/XRN2/DCPS/EXOSC1/EDC4/EXOSC6	4.65831360098449
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	32/1963	75/9376	2.03791475632535	IGF1/GADD45A/CASP3/PPM1D/SIAH1/RCHY1/CDK2/PTEN/PMAIP1/BBC3/CYCS/TNFRSF10B/CCNG2/BID/ATM/CCND3/CCNG1/MDM2/GADD45B/SESN1/COP1/EI24/ATR/APAF1/MDM4/DDB2/CHEK1/RRM2B/CDKN1A/SESN2/CCNB1/CDK1	4.64382969097678
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	30/1963	70/9376	2.04701259005895	JUN/SOS2/GAB1/HGF/PIK3CA/CUL2/SOS1/CDC42/BRAF/TGFB3/VHL/RAP1A/KRAS/PTPN11/CRK/EP300/FLCN/AKT3/HIF1A/ETS1/MAPK1/AKT1/EGLN3/PIK3CB/ELOC/PRCC/CDKN1A/RAP1B/FH/PIK3R3	4.52447494767653
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/1963	119/9376	1.76605007769792	FOS/NFKBIA/MLKL/CXCL2/JUNB/BIRC2/LIF/CASP7/CXCL1/JUN/SOCS3/ATF2/CASP3/ADAM17/MAP3K8/CYLD/PIK3CA/CASP10/DNM1L/IRF1/TNFRSF1A/MAP2K6/FRMD8/CREB1/IKBKB/NFKB1/RIPK1/CEBPB/CREB5/AKT3/MAPK8/TRADD/MAP3K7/MAPK1/TRAF2/AKT1/ICAM1/BAG4/CXCL3/BIRC3/PIK3CB/ATF6B/PIK3R3/CSF1	4.32757195562592
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	66/1963	200/9376	1.57619969434539	FOS/NFKBIA/NCK1/CASP7/JUN/MYH10/CASP3/ARHGEF12/CASP4/CYFIP1/CDC42/NAIP/TRAF6/CYCS/TNFRSF10B/WASL/ARPC5L/MYO5C/NCKAP1/ARF6/CLDN5/TLR5/TNFRSF1A/WASF3/ARPC1B/ARPC1A/MYO1B/IRAK4/ABI1/PYCARD/IKBKB/TNFSF10/PTPN11/MYO6/ACTR2/ARHGEF11/MYO1D/NFKB1/RIPK1/RAB1A/CASP1/SEC24A/MAPK8/TJP1/NCK2/BAIAP2/TRADD/MAP3K7/GNA13/CXCL8/ACTR3/MAPK1/TRAF2/SEC24B/BRK1/HCLS1/CYTH2/MYO5A/ARF1/FYN/OCLN/ARHGEF2/TMBIM6/ACTR3C/ARPC3/WASF1	4.23847969438798
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	69/1963	214/9376	1.54004218224061	FOS/CALR/NFKBIA/TBK1/JUN/CASP3/TRIM5/GNAI3/GNB4/CFL2/CUL5/AP1G1/PRKCA/PIK3CA/CUL4B/TRAF6/CYCS/LIMK2/PTK2/B2M/BTRC/TAP1/BID/PDIA3/GNG12/PPP3R1/ATM/NFATC1/TNFRSF1A/PPP3CC/PPP3CA/CGAS/MAP2K6/IRAK4/SKP1/CUL1/KRAS/IKBKB/CRK/AP1S1/NFKB1/RIPK1/NFATC3/HLA-F/AKT3/TAP2/MAPK8/TRADD/MAP3K7/ATR/RNF7/MAPK1/ITPR1/TRAF2/GNGT2/AKT1/PIK3CB/ELOC/CALM1/GNG11/CHEK1/WEE1/GNG10/DCAF1/GNG5/CCNB1/BST2/PIK3R3/CDK1	4.11233242813186
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	35/1963	93/9376	1.79755585865391	YES1/TGFBR2/SNAI1/ARHGAP29/NECTIN3/RADIL/CDC42/SMAD4/FER/CTNNB1/WASL/AFDN/ACP1/PDCD10/SNAI2/CTNND1/WASF3/CSNK2A2/RAP1A/MYL12A/CTNNA1/KRIT1/EP300/MYL12B/PTPRM/TJP1/BAIAP2/TCF7/MAP3K7/MAPK1/FARP2/FYN/RAP1B/WASF1/ACTN1	3.97747260028743
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	65/1963	205/9376	1.514456469068	OAS1/OAS2/CALR/CDKN1B/NFKBIA/GADD45A/EIF2AK2/HES1/IRF7/TBK1/JUN/CASP3/STAT3/BCL2L11/SAP30L/POLK/MYC/SIN3A/PIK3CA/CDK2/SAP30/TRAF6/CYCS/STAT1/IRF9/RB1/B2M/PSMD12/PSMC6/TAP1/BID/PDIA3/OAS3/CCND3/MAP2K6/MDM2/GADD45B/IRAK4/IFNAR1/IKBKB/SNW1/NFKB1/PSMD11/RIPK1/HLA-F/USP7/AKT3/SKP2/TAP2/MAPK8/NFKBIE/TRADD/MAP3K7/APAF1/ISG15/TRAF2/NFKB2/AKT1/ICAM1/NEDD4/PIK3CB/DDB2/JAK1/CDKN1A/PIK3R3	3.83235740392074
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	28/1963	70/9376	1.91054508405502	CD36/NFKBIA/SOCS3/ACSL3/STAT3/TNFRSF1A/PRKAA1/IKBKB/PTPN11/NFKB1/PRKAA2/ADIPOR2/AKT3/CAMKK2/CPT1A/MAPK8/ACSL4/NFKBIE/TRADD/PRKAG2/ADIPOR1/ACACB/TRAF2/AKT1/LEPR/ACSL5/STK11/JAK2	3.93475537988039
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	30/1963	77/9376	1.86092053641723	CDKN1B/NFKBIA/GADD45A/TGFBR2/SOS2/POLK/MYC/PIK3CA/SOS1/SMAD4/RB1/BRAF/TGFB3/MDM2/GADD45B/KRAS/IKBKB/PTPN11/CRK/NFKB1/AKT3/MAPK1/AKT1/PIK3CB/DDB2/CDKN1A/SHC1/PIK3R3/SHC2/CTBP1	3.90336437652417
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/1963	44/9376	2.17107395915343	TBPL1/TAF7/GTF2B/GTF2H2/GTF2A2/GTF2A1/TAF13/GTF2F1/TAF15/CCNH/TAF8/GTF2I/MNAT1/TAF1/GTF2F2/GTF2E1/TAF9/TAF4/ERCC3/TAF5	4.00656400423823
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	70/1963	227/9376	1.47288717933757	CALR/NFKBIA/TBK1/SOS2/ATF2/CASP3/GNAI3/ARHGEF12/STAT3/GNB4/MYC/PRKCA/PIK3CA/SOS1/GNAS/PLCB1/CYCS/PTK2/CTNNB1/RB1/B2M/TAP1/ITGAV/BID/ADCY4/PDIA3/GNG12/SP1/PPP3R1/NFATC1/TNFRSF1A/PPP3CC/PPP3CA/PLCB4/CGAS/MAP2K6/MDM2/CREB1/KRAS/IKBKB/CRK/ARHGEF11/NFKB1/RIPK1/NFATC3/HLA-F/CREB5/AKT3/TAP2/TRADD/GNA13/CXCL8/MAPK1/ITPR1/TRAF2/GNGT2/AKT1/PIK3CB/ELK1/JAK1/GSK3B/ATF6B/CALM1/GNG11/CDKN1A/ADCY6/GNG10/GNG5/PLCB3/PIK3R3	3.71135452923001
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	63/1963	201/9376	1.49706890914759	DDX5/DDIT3/CDKN1B/IGF1/GADD45A/NFKBIZ/BIRC2/TGFBR2/LMO2/SMAD1/ERG/HHEX/ELK4/ETV6/POLK/MYC/SIN3A/MEF2C/JMJD1C/MAF/CDKN2C/PTK2/MLF1/CCNT2/REL/SP1/ATM/PPARG/DUSP6/MAX/EWSR1/KDM6A/FLI1/MDM2/PML/GADD45B/TAF15/BCL6/BMP2K/FUT8/KLF3/SLC45A3/AFF1/NFKB1/ATF1/CEBPB/MYCN/CXCL8/PLAT/SS18/BIRC3/BMI1/DDB2/ETV1/FUS/PRCC/CDKN1A/NSD2/KMT2A/SS18L1/SUPT3H/CCNT1/RARA	3.66572920653959
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	64/1963	205/9376	1.49115713877465	DDX3X/CDKN1B/NFKBIA/EIF2AK2/TBPL1/IRF7/JUN/ATF2/CASP3/SP100/STAT3/PIK3CA/CDK2/GTF2B/PMAIP1/CDC42/IRF9/EGR3/KAT2B/RB1/GTF2H2/GTF2A2/REL/GTF2A1/RASA2/CCND3/VDAC3/MDM2/RBL2/CREB1/YWHAG/IL6ST/KRAS/SNW1/EP300/NFKB1/HLA-F/UBE3A/USP7/CREB5/YWHAQ/SKP2/HDAC8/DLG1/TRADD/MAPK1/TRAF2/POLB/RANBP1/NFKB2/GTF2E1/KAT2A/PIK3CB/YWHAZ/JAK1/ATF6B/HNRNPK/CHEK1/CDKN1A/PIK3R3/DNAJA3/CDK1/ACTN1/RBL1	3.6587929405991
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	48/1963	144/9376	1.59212090337918	TBPL1/XBP1/PSMA2/NRBF2/PRKCA/PIK3CA/GTF2B/PLCB1/CYCS/OPA1/PSMD12/PSMC6/ATXN3/SP1/ATP2A2/PIK3R4/VDAC3/PLCB4/RELN/SLC25A5/ATG101/PSMA3/PSMB2/PSMD11/PIK3C3/ATXN2/AKT3/MAPK8/OMA1/PSMA5/ATXN2L/NFYA/ATG2B/ITPR1/PSMA1/TRAF2/GRIN2B/AKT1/ATXN1/ATXN1L/VDAC2/PIK3CB/PUM2/VDAC1/PSMA6/PLCB3/PIK3R3/VLDLR	3.68461850702973
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	33/1963	90/9376	1.7513329937171	FOS/NFKBIA/IFNGR1/JUN/STAT3/PIK3CA/PTEN/IFNGR2/TRAF6/STAT1/PPP3R1/NFATC1/PPP3CC/CSNK2A2/PPP3CA/MAP2K6/KRAS/IKBKB/PTPN11/NFKB1/CD274/NFATC3/AKT3/HIF1A/BATF3/NFKBIE/MAPK1/AKT1/EML4/PIK3CB/JAK1/JAK2/PIK3R3	3.68542997391153
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	29/1963	77/9376	1.79888985186998	GADD45A/TGFBR2/STAT3/POLK/PIK3CA/CDC42/SMAD4/RALB/STAT1/RB1/BRAF/TGFB3/GADD45B/BRCA2/KRAS/IKBKB/NFKB1/RALGDS/AKT3/PLD1/MAPK8/ARHGEF6/MAPK1/AKT1/PIK3CB/DDB2/JAK1/CDKN1A/PIK3R3	3.62212080749428
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	41/1963	122/9376	1.60517107471835	VAV3/FOS/NFKBIA/NCK1/PPP2R5A/JUN/SOS2/MAP3K8/BCL10/PIK3CA/SOS1/CDC42/PPP2R3C/PPP3R1/PPP2R5C/NFATC1/PPP3CC/PPP3CA/PPP2CB/PPP2R2D/KRAS/IKBKB/PTPN11/NFKB1/NFATC3/PPP2CA/AKT3/MAPK8/DLG1/NCK2/NFKBIE/MAP3K7/MAPK1/PPP2R1B/AKT1/PIK3CB/FYN/GSK3B/MALT1/PPP2R5B/PIK3R3	3.46212000647698
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	86/1963	300/9376	1.3692239769061	HSPA1A/HSPA1B/HSPA8/DUSP1/EFNA5/FOS/DDIT3/MKNK2/IGF1/GADD45A/RASGRP3/JUND/TGFBR2/CDC25B/JUN/STK3/SOS2/ATF2/HSPA6/CASP3/EFNA1/PGF/HGF/ELK4/STMN1/MAP3K8/DUSP5/MYC/PRKCA/RPS6KA3/MEF2C/SOS1/CDC42/TRAF6/FLT4/LAMTOR3/KDR/GNG12/MAP4K3/BRAF/MAP3K1/MAP3K12/TGFB3/PPP3R1/MAP4K2/MAP3K4/NFATC1/DUSP6/RASA2/TNFRSF1A/MAX/PPP3CC/PPP3CA/PPM1A/MAP2K6/GADD45B/IRAK4/DUSP8/RAP1A/KRAS/PLA2G4C/IKBKB/DUSP10/CRK/NFKB1/NFATC3/MAPK7/AKT3/RAPGEF2/MAPK8/TEK/TRADD/MAP3K7/MAPK1/TRAF2/NFKB2/AKT1/NF1/MAP2K5/ECSIT/ELK1/EFNA4/RAP1B/RASGRF2/CSF1/TAOK2	3.34466070185111
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	27/1963	72/9376	1.79113601630158	DDX3X/NFKBIA/IRF7/TBK1/RNF125/TRIM25/AZI2/CYLD/CASP10/TRAF6/TANK/IFIH1/MAP3K1/ADAR/ATG5/ATG12/IKBKB/NFKB1/RIPK1/OTUD5/MAPK8/TRADD/MAP3K7/CXCL8/ISG15/TRAF2/IL12A	3.46761874068732
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	15/1963	32/9376	2.23892002037697	ATG4C/GABARAPL2/ATG5/PIK3R4/PPP2CB/ATG12/ATG3/ATG101/PPP2CA/PIK3C3/ATG2B/IGBP1/ATG10/ATG16L1/ATG9A	3.61243992269578
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	40/1963	120/9376	1.59212090337918	NFKBIA/JUN/SOS2/GAB1/CAMK2D/RPS6KA3/PIK3CA/SOS1/CDC42/TRAF6/RIPK2/KIDINS220/BRAF/MAP3K1/IRAK3/IRAK4/RAP1A/KRAS/IKBKB/PTPN11/CRK/NFKB1/PSEN1/MAPK7/AKT3/MAPK8/NFKBIE/MAPK1/ZNF274/AKT1/MAP2K5/PIK3CB/GSK3B/CALM1/FRS2/SHC1/RAP1B/PIK3R3/SHC2/IRAK2	3.35921755363508
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	73/1963	250/9376	1.39469791136016	NCOA7/VPS13C/VPS26A/AP1G1/VPS13A/CLN5/LAMTOR3/SCARB2/DTNBP1/ATP6V1C1/OSBP/LAPTM4A/LAMP2/STX17/CLN8/M6PR/CD164/ATP6V1D/ARL8B/AP4M1/GALC/AP3M1/CLTC/AP1S1/LIPA/RRAGB/PLEKHM1/ROGDI/ABCA5/GNPTAB/ENTPD4/CTSH/CTBS/ATP6V0A1/BLOC1S2/SLC15A3/BORCS7/NPC1/TPCN1/SNAPIN/AP3M2/BORCS6/SPG11/WDR7/NEU1/BLOC1S5/GNPTG/CTSS/RAB7A/PLA2G15/ATP6V1B2/VPS29/AP4S1/MAN2B1/ATP6V1G1/SLC38A9/LAPTM4B/TTI1/AP2M1/GLA/SLC36A4/NAGPA/PIKFYVE/HEXA/GGA2/LAMP3/BORCS8/VPS26B/TLR3/LAPTM5/CLTA/ATP6V1C2/AKT1S1	3.25494300451789
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	23/1963	59/9376	1.86197190395192	GADD45A/SOS2/POLK/MYC/PIK3CA/PTEN/SOS1/CTNNB1/BRAF/GADD45B/KRAS/CTNNA1/AKT3/APC/TCF7/MAPK1/AKT1/PIK3CB/DDB2/ELK1/GSK3B/CDKN1A/PIK3R3	3.41766787503094
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	22/1963	56/9376	1.87642820755404	MAN1A1/MGAT5/STT3B/ALG13/ST6GAL1/TUSC3/MGAT2/MAN2A1/FUT8/OSTC/DDOST/ALG6/SRD5A3/B4GALT1/ALG10/MGAT4C/DPM1/DPAGT1/ALG11/ALG8/DAD1/MAN1C1	3.38494169158014
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	15/1963	33/9376	2.17107395915343	SEC22B/STX11/GOSR1/VAMP4/SNAP23/BET1/VAMP3/STX7/STX17/VTI1A/STX5/STX6/STX3/GOSR2/STX1B	3.46774302807981
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	44/1963	137/9376	1.53401430106607	FOS/DDIT3/NFKBIA/GADD45A/BIRC2/PARP4/CASP7/JUN/CASP3/BCL2L11/MCL1/PIK3CA/PMAIP1/EIF2S1/BBC3/CASP10/CYCS/TNFRSF10B/BID/SPTAN1/ATM/TNFRSF1A/CAPN2/GADD45B/KRAS/IKBKB/TNFSF10/NFKB1/RIPK1/AKT3/CTSH/MAPK8/CASP2/TRADD/HTRA2/APAF1/MAPK1/ITPR1/TRAF2/CTSS/AKT1/BIRC3/PIK3CB/PIK3R3	3.2400333143233
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	40/1963	122/9376	1.56602056070083	FOS/IGF1/JUNB/SOCS3/SOS2/ATF2/GNAI3/STAT3/SOCS2/PRKCA/PIK3CA/SOS1/GNAS/PLCB1/STAT1/PTK2/ADCY4/MAP3K1/SOCS1/PLCB4/MAP2K6/CREB1/KRAS/CRK/EP300/CREB5/AKT3/MAPK8/MAPK1/ITPR1/AKT1/PIK3CB/GSK3B/ATF6B/SHC1/ADCY6/JAK2/PLCB3/PIK3R3/SHC2	3.23814403752143
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	49/1963	157/9376	1.49071192864165	CD36/CALR/CASP7/CASP3/GAS6/CD47/ADAM17/SIRT1/DUSP5/CAMK2D/ANO6/RAB5A/SIRPA/DOCK1/PTK2/TMEM30A/ITGAV/NFATC1/PPARG/ATP11A/ATP11B/ATP2A2/SCARF1/PROS1/CREB1/TGFBRAP1/ADAM10/DUSP8/S1PR1/PANX1/NR1H2/PTPN11/CRK/LIPA/NFATC3/PECAM1/CEBPB/CASP1/CPT1A/HIF1A/ARG2/VPS8/MAPK1/MERTK/PPARD/RAB7A/PLA2G15/STAB2/JAK2	3.19068052817524
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	44/1963	138/9376	1.52289825540617	VAV3/FOS/NFKBIA/ARHGEF7/TBK1/JUN/ARHGEF12/SKAP2/RPS6KA3/PIK3CA/CDC42/TRAF6/DOCK1/PTK2/WASL/ARPC5L/ARF6/NFATC1/ARPC1B/ARPC1A/MAP2K6/IRAK4/PYCARD/IKBKB/CRK/ACTR2/NFKB1/NFATC3/CASP1/PKN2/AKT3/MAPK8/BAIAP2/MAP3K7/CXCL8/ACTR3/MAPK1/TRAF2/AKT1/PIK3CB/GSK3B/ACTR3C/ARPC3/PIK3R3	3.18431883037668
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	52/1963	170/9376	1.46100506427737	HSPA4/PARD6G/MPDZ/YBX3/JUN/MYH10/WHAMM/RAB8A/CDC42/AMOT/RAB13/CGNL1/ARPC5L/RAP2C/ARHGAP17/AFDN/RAB8B/MAP3K1/CLDN5/ARPC1B/ARPC1A/PPP2CB/RAP1A/MYL12A/PPP2R2D/PRKAA1/ACTR2/PPP2CA/PRKAA2/MSN/MYL12B/RAPGEF2/MAPK8/AMOTL1/F11R/DLG1/TJP1/PRKAG2/PCNA/ACTR3/DLG2/PPP2R1B/HCLS1/NEDD4/OCLN/ARHGEF2/TJP2/STK11/ACTR3C/ARPC3/PATJ/ACTN1	3.12135711791095
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	31/1963	90/9376	1.64519160015849	IGF1/ATF2/SOD2/SIRT1/PIK3CA/ADCY4/PPARG/ATG5/EHMT2/CREB1/PRKAA1/KRAS/ATG101/SESN1/EHMT1/NFKB1/PRKAA2/CREB5/ADIPOR2/AKT3/CAMKK2/PRKAG2/ADIPOR1/AKT1/PIK3CB/ATF6B/SESN2/ADCY6/STK11/PIK3R3/AKT1S1	3.16478642895237
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	35/1963	105/9376	1.59212090337918	NFKBIA/JUN/ARHGEF12/BCL10/CYLD/PIK3CA/STAT1/IRF9/EGR3/IRF1/PLK3/PPP3R1/NFATC1/PPP3CC/PPP3CA/MDM2/PYCARD/KRAS/IKBKB/CLEC4M/PTPN11/NFKB1/NFATC3/CASP1/AKT3/MAPK8/MAPK1/ITPR1/NFKB2/AKT1/PIK3CB/MALT1/CALM1/PIK3R3/IL12A	3.13971725672091
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	29/1963	83/9376	1.66884962161432	PEX13/SOD2/ACSL3/ABCD4/IDH1/HSD17B4/SCP2/AGPS/FAR1/SOD1/PHYH/PEX2/NUDT7/PECR/CROT/ECI2/PRDX1/FAR2/ACSL4/ABCD3/PMVK/DHRS4/PEX1/PXMP4/ACSL5/EPHX2/HACL1/MPV17L2/NUDT12	3.14947634829651
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	48/1963	157/9376	1.4602892362204	FOS/DDIT3/XBP1/CASP7/JUN/SOCS3/CASP3/BCL2L11/SDHD/PIK3CA/EIF2S1/CDC42/CYCS/NDUFB5/BID/NDUFC2/PPARG/NDUFA5/TNFRSF1A/NDUFB3/MLXIP/NDUFV2/PRKAA1/IKBKB/NDUFA8/NFKB1/PRKAA2/ADIPOR2/MLX/AKT3/MAPK8/NDUFB8/PRKAG2/CXCL8/NDUFC1/NDUFS4/ADIPOR1/TRAF2/UQCRC2/AKT1/COX7A2L/LEPR/PIK3CB/NDUFB6/GSK3B/UQCRH/NDUFB4/PIK3R3	2.99286774503816
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	91/1963	333/9376	1.30525227213969	MX1/CDKN1B/PARD6G/ITGA2/EIF2AK2/PPP2R5A/TBPL1/HES1/TBK1/SOS2/CASP3/MAML2/MX2/HEY1/PIK3CA/CDK2/NOTCH1/PTEN/SOS1/GNAS/CDC42/PPP2R3C/STAT1/IRF9/FZD6/PTK2/CTNNB1/IRF1/RB1/LAMB1/ITGAV/ATP6V1C1/PPP2R5C/ITGA1/ATM/CCND3/HES4/COL4A1/CSNK1A1/TNFRSF1A/ATP6V1D/ITGA9/MDM2/PPP2CB/RBL2/CREB1/RELN/ITGA6/PPP2R2D/IFNAR1/KRAS/IKBKB/EP300/NFKB1/COL9A3/HLA-F/PPP2CA/UBE3A/PSEN1/CREB5/AKT3/APC/COL4A5/ATP6V0A1/DLG1/TRADD/TCF7/ATR/ISG15/MAPK1/DLG2/PPP2R1B/AKT1/ATP6V1B2/PIK3CB/HES6/JAK1/GSK3B/ATP6V1G1/LAMC2/CDKN1A/FZD9/DVL3/DVL1/TLR3/PPP2R5B/PIK3R3/ITGA8/PATJ/ATP6V1C2/RBL1	2.91859305407792
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	44/1963	142/9376	1.47999971300037	FOS/NFKBIA/JUND/JUNB/TGFBR2/IFNGR1/JUN/SOCS3/CYLD/PIK3CA/IFNGR2/SIRPA/TRAF6/STAT1/IRF9/PPP3R1/NFATC1/PPARG/TNFRSF1A/SOCS1/FOSB/ATP2A2/PPP3CC/PPP3CA/MAP2K6/CREB1/IFNAR1/IKBKB/NFKB1/AKT3/MAPK8/MAP3K7/MAPK1/ITPR1/TRAF2/FOSL1/NFKB2/AKT1/PIK3CB/JAK1/FYN/TNFRSF11A/PIK3R3/CSF1	2.96578048196011
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1963	32/9376	2.08965868568518	BIRC2/CASP7/CASP3/BCL2L11/PMAIP1/BBC3/CYCS/BID/TNFRSF1A/BIRC6/MAPK8/HTRA2/APAF1/BIRC3	3.17722409319337
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	48/1963	158/9376	1.45104689928229	IGF1/SOS2/PRKCA/PRR5/RPS6KA3/PIK3CA/PTEN/SOS1/FZD6/LAMTOR3/RNF152/FNIP2/ATP6V1C1/BRAF/TNFRSF1A/FNIP1/LPIN2/RICTOR/ATP6V1D/EIF4B/MAPKAP1/PRKAA1/KRAS/IKBKB/RRAGB/FLCN/PRKAA2/AKT3/PRR5L/SKP2/MAPK1/LRP6/AKT1/ATP6V1B2/PIK3CB/GSK3B/ATP6V1G1/SLC38A9/CASTOR1/TTI1/SESN2/FZD9/STK11/DVL3/DVL1/PIK3R3/ATP6V1C2/AKT1S1	2.94225751740025
Genetic Information Processing	Transcription	hsa03040	Spliceosome	69/1963	243/9376	1.3562511399156	HSPA1A/HSPA1B/HSPA8/DDX5/SRSF7/DDX39B/TRA2A/SRSF1/HSPA6/HNRNPA3/SRSF2/SRSF3/SF3B1/SRSF6/PRPF38A/SRSF5/RBMXL1/SRSF10/TRA2B/SRSF9/EIF4A3/PRPF8/SNRPA1/SF1/THOC1/PHF5A/SNRNP40/LSM8/BCAS2/DHX15/DHX8/DDX23/HNRNPU/ISY1/PRPF3/USP39/LSM6/SRSF8/SRSF4/LSM2/BUD31/SMNDC1/SNW1/AQR/MAGOH/CWC15/BUD13/NCBP1/SF3B6/THOC7/DHX38/SNRPB2/RBM22/PPIH/HNRNPA1/CDC40/THOC3/LSM5/CHERP/SNRPA/PLRG1/FUS/PRPF31/HNRNPK/YJU2/THOC5/RP9/THOC6/SF3A1	2.89535258871841
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/1963	23/9376	2.28434738310926	HMGCS1/IDI1/GGPS1/FNTA/NUS1/ACAT2/ZMPSTE24/HMGCR/PDSS2/PMVK/FNTB	3.17336292832885
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	25/1963	71/9376	1.68181785568223	FOS/SOCS3/SOS2/STAT3/SOCS2/PIK3CA/SOS1/STAT1/IRF1/SOCS4/SOCS1/KRAS/NFKB1/AKT3/SOCS6/MAPK8/MAPK1/AKT1/PIK3CB/GSK3B/SHC1/TNFRSF11A/JAK2/PIK3R3/SHC2	2.96748234675416
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	31/1963	94/9376	1.57518344696025	HSP90AA1/HSP90AB1/FOS/NFKBIA/CXCL2/JUND/SRSF1/CXCL1/TBK1/JUN/CASP3/TRAF6/FOSB/HSP90B1/IKBKB/ELAVL1/USP25/NFKB1/CEBPB/MAPK7/ANAPC5/MAPK8/TRADD/MAP3K7/CXCL8/MAPK1/TRAF2/FOSL1/CXCL3/GSK3B/TRAF3IP2	2.88402029237417
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	39/1963	125/9376	1.49022516556291	PPP2R5A/GNAI3/PRKCA/PIK3CA/DEGS1/PTEN/PLCB1/PPP2R3C/SPTLC2/BID/PPP2R5C/CERS2/ORMDL1/TNFRSF1A/SPTLC1/PLCB4/PPP2CB/PPP2R2D/S1PR1/KRAS/NFKB1/PPP2CA/AKT3/PLD1/MAPK8/TRADD/GNA13/MAPK1/TRAF2/PPP2R1B/AKT1/SGMS1/PIK3CB/FYN/NSMAF/CERS5/PLCB3/PPP2R5B/PIK3R3	2.83925929241724
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	42/1963	138/9376	1.45367560743317	IGF1/PPP2R5A/CAMK2D/RPS6KA3/CDK2/PPP1CC/BTRC/ADCY4/CDC23/PPP3R1/CPEB2/PPP2R5C/CDC16/PPP3CC/PPP3CA/ANAPC10/CDC26/PPP2CB/SKP1/YWHAG/CUL1/CDC27/PPP1CB/PPP2CA/ANAPC16/YWHAQ/ANAPC5/ANAPC7/ANAPC13/MAPK1/ITPR1/ANAPC1/PPP2R1B/FBXO5/YWHAZ/CALM1/ADCY6/SLK/CCNB1/ANAPC4/PPP2R5B/CDK1	2.76277031850076
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	22/1963	62/9376	1.69483838101655	HES1/DTX3L/NUMB/DLL4/ADAM17/MAML2/TLE4/HEY1/NOTCH1/NRARP/KAT2B/SNW1/EP300/PSEN1/TLE1/SPEN/ATXN1/ATXN1L/KAT2A/DVL3/DVL1/CTBP1	2.82462185844264
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/1963	48/9376	1.79113601630158	ALDH2/HMGCS1/HADH/ALDH9A1/HIBCH/HADHB/ALDH3A2/ACADM/PCCA/ACAT2/DBT/HIBADH/HSD17B10/MCCC1/DLD/ALDH6A1/AUH/ACAD8	2.82765417718105
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/1963	112/9376	1.49261334691798	HSPA1A/HSPA1B/HSPA8/NFKBIA/BIRC2/IFNGR1/HSPA6/CASP3/LY96/GNAI3/STAT3/IFNGR2/TRAF6/CYCS/STAT1/LAMB1/TGFB3/TNFRSF1A/SOCS1/MAP2K6/IRAK4/ITGA6/IKBKB/NFKB1/AKT3/MAPK8/MAP3K7/MAPK1/AKT1/BIRC3/JAK1/LAMC2/PIK3CG/JAK2/IL12A	2.69876270925408
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	44/1963	148/9376	1.41999972463549	FOS/IGF1/GADD45A/HES1/JUN/SOS2/DLL4/HEY1/POLK/MYC/PIK3CA/NOTCH1/PTEN/SOS1/FZD6/FLT4/CTNNB1/RB1/FRAT2/BRAF/SP1/CSNK1A1/GADD45B/BRCA2/KRAS/NCOA1/AKT3/APC/TCF7/MAPK1/LRP6/NFKB2/AKT1/NCOA3/PIK3CB/DDB2/GSK3B/CDKN1A/SHC1/FZD9/DVL3/DVL1/PIK3R3/SHC2	2.65017686460043
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	32/1963	101/9376	1.51330303687526	CDKN1B/TGFBR2/JUN/CASP3/STAT3/PRKCA/PIK3CA/CDC42/PLCB1/SMAD4/STAT1/TGFB3/NFATC1/COL4A1/PLCB4/KRAS/NFKB1/THBD/AKT3/MAPK8/COL4A5/CXCL8/MAPK1/PLCE1/AKT1/ICAM1/PIK3CB/NOX4/JAK2/PLCB3/PIK3R3/EGR1	2.66886342123943
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	34/1963	109/9376	1.48987460683189	CD36/NFKBIA/TBC1D4/SOCS3/STAT3/RPS6KA3/PIK3CA/PTEN/PPP1CC/OGT/TNFRSF1A/MLXIP/CREB1/PRKAA1/IKBKB/NR1H2/PTPN11/NFKB1/PPP1CB/PRKAA2/CREB5/MLX/AKT3/CPT1A/MAPK8/PRKAG2/ACACB/AKT1/SLC27A3/PIK3CB/GSK3B/CRTC2/PPP1R3D/PIK3R3	2.64714288164786
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	25/1963	75/9376	1.59212090337918	GSTM3/MGST2/BIRC2/CASP3/PIK3CA/PMAIP1/MSH6/BBC3/CYCS/TOP2B/BID/ATM/MDM2/MSH2/MSH3/AKT3/APAF1/MGST3/MAPK1/AKT1/BIRC3/PIK3CB/CDKN1A/GSTO1/PIK3R3	2.64926249000962
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	49/1963	170/9376	1.37671631056906	GSTM3/GADD45A/MGST2/TGFBR2/SOS2/GAB1/HGF/POLK/MYC/PRKCA/PIK3CA/PTEN/SOS1/SMAD4/ARID1B/FZD6/CTNNB1/RB1/SMARCE1/FRAT2/BRAF/TGFB3/ARID2/CSNK1A1/GADD45B/PHF10/ACTL6A/KRAS/TXNRD1/BRD7/AKT3/APC/TCF7/MGST3/MAPK1/LRP6/AKT1/PIK3CB/DDB2/ELK1/GSK3B/CDKN1A/SHC1/FZD9/DVL3/GSTO1/DVL1/PIK3R3/SHC2	2.55065774444597
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	37/1963	122/9376	1.44856901864827	CD36/IGF1/PPP2R5A/SIRT1/RAB8A/PIK3CA/PPP2R3C/RAB10/PPP2R5C/PPARG/PPP2CB/CREB1/PPP2R2D/PRKAA1/ELAVL1/PPP2CA/PRKAA2/CREB5/ADIPOR2/AKT3/CAMKK2/CPT1A/PRKAG2/MAP3K7/ADIPOR1/HMGCR/ACACB/PPP2R1B/AKT1/LEPR/PIK3CB/CRTC2/STK11/PFKFB3/PPP2R5B/PIK3R3/AKT1S1	2.56621613065477
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	42/1963	142/9376	1.41272699877308	HSP90AA1/HSP90AB1/DUSP1/KLF2/FOS/GSTM3/MGST2/JUN/SUMO1/SDC4/PIK3CA/MEF2C/PTK2/CTNNB1/ITGAV/KDR/TNFRSF1A/HSP90B1/MAP2K6/PRKAA1/IKBKB/NFKB1/THBD/PECAM1/PRKAA2/MAPK7/AKT3/MAPK8/SUMO2/MAP3K7/MGST3/PLAT/SUMO4/AKT1/ICAM1/MAP2K5/PIK3CB/ACVR2B/CALM1/ARHGEF2/GSTO1/PIK3R3	2.55012168588157
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/1963	73/9376	1.57031102799043	MX1/TRIM5/XPO1/MX2/KAT2B/CCNT2/MDFIC/SERINC3/PDCD6IP/CPSF6/NUP153/EP300/CHMP4B/ELL2/RANBP2/CPSF7/RAN/TSG101/SERINC5/KAT2A/NELFCD/PPIA/CCNT1/BST2	2.51715800191554
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	42/1963	144/9376	1.39310579045678	ALDH2/NFKBIA/CXCL2/TRA2A/CXCL1/TBK1/CASP3/LY96/SIRT1/TRAF6/CTNNB1/TRA2B/TNFRSF1A/LPIN2/ALDH9A1/MAP2K6/IRAK4/PRKAA1/IKBKB/ACADVL/ALDH3A2/ACADM/NFKB1/RIPK1/PRKAA2/ADIPOR2/AKT3/CAMKK2/CPT1A/MAPK8/TRADD/TCF7/PRKAG2/MAP3K7/CXCL8/ADIPOR1/ACACB/AKT1/CXCL3/GSK3B/NOX4/IL12A	2.44619783302949
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	21/1963	62/9376	1.61780027278852	HSPA1A/HSPA1B/HSPA8/IGF1/HSPA6/SOD2/SIRT1/PIK3CA/ADCY4/SOD1/ATG5/PRKAA1/KRAS/PRKAA2/AKT3/PRKAG2/AKT1/PIK3CB/ADCY6/PIK3R3/AKT1S1	2.51145043559234
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1963	23/9376	2.07667943919024	MSH6/MSH2/MSH3/RPA3/POLD3/PCNA/PMS2/MLH3/RFC4/RFC5	2.66025739060469
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	45/1963	157/9376	1.36902115895662	SAV1/PARD6G/ID1/BIRC2/TGFBR2/STK3/SMAD1/BMP2/MYC/TP53BP2/PPP1CC/BBC3/SMAD4/TEAD2/MOB1A/AMOT/FZD6/YAP1/CTNNB1/BTRC/WWTR1/TGFB3/CCND3/SNAI2/PPP2CB/YWHAG/LATS1/PPP2R2D/CTNNA1/PPP1CB/PPP2CA/YWHAQ/APC/DLG1/TCF7/DLG2/PPP2R1B/BIRC3/YWHAZ/GSK3B/FZD9/DVL3/DVL1/PATJ/DLG4	2.39942939562689
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	32/1963	105/9376	1.45565339737525	NFKBIA/CXCL2/GADD45A/BIRC2/CXCL1/LY96/TRIM25/BCL10/CYLD/TRAF6/CCL21/ATM/TNFRSF1A/CSNK2A2/GADD45B/IRAK4/IKBKB/CARD10/NFKB1/RIPK1/ERC1/TRADD/MAP3K7/CXCL8/UBE2I/TRAF2/NFKB2/ICAM1/CXCL3/BIRC3/MALT1/TNFRSF11A	2.41609918963872
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1963	105/9376	1.45565339737525	CALCOCO2/TBK1/JUN/SIAH1/MAP1LC3B/EIF2S1/RAB5A/OPA1/RHOT1/MTX2/MFN1/TBC1D15/SP1/GABARAPL2/USP15/NBR1/CSNK2A2/KRAS/ARIH1/CCZ1B/MAPK8/HIF1A/VCP/UBB/TRAF2/RAB7A/HUWE1/TOMM20/CCZ1/OPTN/UBC/ATG9A	2.41609918963872
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	39/1963	133/9376	1.40058756161928	FOS/PPP2R5A/ATF2/GNAI3/GNB4/CAMK2D/PRKCA/GNAS/PPP1CC/PLCB1/PPP2R3C/GNG12/PPP2R5C/PPP3CC/PPP3CA/PLCB4/PPP2CB/CREB1/PPP2R2D/PPP1CB/PPP2CA/CREB5/AKT3/MAPK8/ITPR1/GRIN2B/PPP2R1B/GNGT2/AKT1/LRTOMT/COMT/GSK3B/ATF6B/CALM1/GNG11/GNG10/GNG5/PLCB3/PPP2R5B	2.39422847741225
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1963	30/9376	1.91054508405502	SDHD/SUCLA2/IDH1/ACO1/ACLY/MDH1/DLST/IDH3A/PDHB/SUCLG2/DLD/FH	2.57038383295812
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1963	37/9376	1.8072723768088	GADD45A/POLK/MYC/CTNNB1/BRAF/PPARG/GADD45B/TFG/KRAS/CCDC6/TCF7/MAPK1/DDB2/CDKN1A	2.53174262967771
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	25/1963	78/9376	1.53088548401844	GAB1/PIK3CA/CDC42/DOCK1/PTK2/CTNNB1/WASL/ARPC5L/ARPC1B/ARPC1A/CD2AP/CTNNA1/CLTC/CRK/ACTR2/ACTR3/HCLS1/PIK3CB/SHC1/ACTR3C/CLTA/ARPC3/PIK3R3/SHC2/WASF1	2.42271411167176
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/1963	59/9376	1.61910600343646	CMPK2/NT5C3A/NT5C2/DHODH/CMPK1/DCK/NT5E/CDADC1/DUT/ENTPD4/NME7/NT5C3B/DTYMK/NUDT2/DPYD/RRM2B/CTPS2/UCKL1/UMPS/TYMS	2.45471887132598
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	21/1963	63/9376	1.59212090337918	CUL4B/POLR2K/GTF2H2/POLR2M/POLR2H/POLR2B/CCNH/POLE4/POLR2C/RPA3/POLD3/MNAT1/RAD23B/PCNA/ERCC6/DDB2/RFC4/POLR2D/ERCC3/ERCC4/RFC5	2.426524352554
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	38/1963	130/9376	1.39616756142482	FOS/NFKBIA/TGFBR2/JUN/SOS2/ATF2/EDNRB/GNAI3/GNB4/PRKCA/PIK3CA/SOS1/GNAS/PLCB1/ADCY4/GNG12/COL4A1/PLCB4/CREB1/KRAS/NFKB1/CREB5/AKT3/MAPK8/COL4A5/MAPK1/GNGT2/AKT1/PIK3CB/ATF6B/GNG11/SHC1/ADCY6/GNG10/GNG5/PLCB3/PIK3R3/SHC2	2.34057429827356
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	36/1963	122/9376	1.40941850463075	TBC1D4/MYC/PRKCA/SIN3A/PIK3CA/NOTCH1/MED13/PLCB1/STAT1/KAT2B/CTNNB1/ITGAV/MED4/ATP2A2/PLCB4/MDM2/MED30/KRAS/NCOA1/EP300/THRA/ATP1A1/AKT3/MED13L/HIF1A/MAPK1/PLCE1/AKT1/MED14/NCOA3/KAT2A/PIK3CB/MED17/GSK3B/PLCB3/PIK3R3	2.34224016169922
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	32/1963	106/9376	1.44192081815473	HSP90AA1/HSP90AB1/CDKN1B/NFKBIA/IGF1/SOS2/ERG/PIK3CA/CDK2/PTEN/SOS1/CTNNB1/RB1/BRAF/HSP90B1/MDM2/CREB1/NKX3-1/KRAS/IKBKB/EP300/NFKB1/CREB5/AKT3/TCF7/PLAT/MAPK1/AKT1/PIK3CB/GSK3B/CDKN1A/PIK3R3	2.35454130984063
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	64/1963	238/9376	1.28440005650757	EFNA5/IGF1/RASGRP3/TBK1/ETS2/SOS2/GAB1/EFNA1/PGF/HGF/GNB4/PRKCA/PIK3CA/SOS1/SHOC2/CDC42/RAB5A/RALB/FLT4/RALGAPA2/RAPGEF5/ARF6/REL/AFDN/KDR/GNG12/RALGAPA1/RASA2/BRAP/RAP1A/KRAS/PLA2G4C/IKBKB/PTPN11/NFKB1/RALGDS/RGL2/AKT3/EXOC2/PLD1/MAPK8/ETS1/TEK/MAPK1/PLCE1/GRIN2B/GNGT2/AKT1/NF1/PIK3CB/RASA3/ELK1/EFNA4/CALM1/GNG11/SHC1/RAP1B/GNG10/GNG5/PIK3R3/RASGRF2/SYNGAP1/SHC2/CSF1	2.28686942426112
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1963	34/9376	1.82625633034671	NFIL3/BTRC/CREB1/SKP1/CUL1/PRKAA1/PRKAA2/PER1/PRKAG2/BHLHE40/FBXL3/NR1D2/NPAS2	2.4836083702209
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	23/1963	71/9376	1.54727242722766	NFKBIA/CXCL2/CXCL1/JUN/CASP3/ADAM17/CDC42/ATP6V1C1/ATP6V1D/ADAM10/IKBKB/PTPN11/NFKB1/MAPK8/ATP6V0A1/F11R/TJP1/CXCL8/CXCL3/ATP6V1B2/ATP6V1G1/NOD1/ATP6V1C2	2.38189899711318
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	40/1963	139/9376	1.37449286622663	HSPA1A/HSPA1B/HSP90AA1/HSP90AB1/HSPA8/FKBP4/FOS/JUN/SOS2/ATF2/HSPA6/GNAI3/PIK3CA/SOS1/GNAS/PLCB1/ADCY4/SP1/HSP90B1/PLCB4/CREB1/KRAS/NCOA1/CREB5/AKT3/GABBR1/FKBP5/MAPK1/ITPR1/AKT1/NCOA3/PIK3CB/ATF6B/CALM1/SHC1/ADCY6/PLCB3/PIK3R3/SHC2/RARA	2.28893924508664
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	47/1963	168/9376	1.33624432962181	HSP90AA1/HSP90AB1/PPID/MLKL/EIF2AK2/BIRC2/IFNGR1/STAT3/CAMK2D/CHMP5/CYLD/IFNGR2/STAT1/IRF9/TNFRSF10B/DNM1L/BID/TRPM7/GLUD1/TNFRSF1A/VDAC3/CAPN2/PYCARD/IFNAR1/CHMP7/SLC25A5/PLA2G4C/TNFSF10/CHMP4B/RIPK1/CASP1/SPATA2L/MAPK8/SHARPIN/TRADD/RBCK1/TRAF2/SPATA2/VDAC2/BIRC3/CHMP1B/JAK1/VDAC1/USP21/PPIA/JAK2/TLR3	2.26295408711959
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	31/1963	103/9376	1.43754605839091	FOS/CALR/NFKBIA/TGFBR2/IFNGR1/JUN/GNAI3/PIK3CA/IFNGR2/GNAS/PLCB1/TRAF6/TGFB3/TNFRSF1A/PLCB4/PPP2CB/IRAK4/PPP2R2D/IKBKB/NFKB1/PPP2CA/AKT3/MAPK8/CXCL8/MAPK1/PPP2R1B/AKT1/PIK3CB/PLCB3/PIK3R3/IL12A	2.29763504250092
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1963	76/9376	1.50832506635922	IGF1/GADD45A/SOS2/POLK/CAMK2D/PRKCA/PIK3CA/PTEN/SOS1/RB1/BRAF/MDM2/GADD45B/KRAS/AKT3/MAPK1/AKT1/PIK3CB/DDB2/CALM1/CDKN1A/SHC1/PIK3R3/SHC2	2.28957901440277
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1963	80/9376	1.49261334691798	IGF1/SOS2/GAS6/GAB1/HGF/STAT3/BCL2L11/PRKCA/PIK3CA/PTEN/SOS1/KDR/BRAF/KRAS/AKT3/MAPK1/AKT1/NF1/PIK3CB/JAK1/GSK3B/SHC1/JAK2/PIK3R3/SHC2	2.27694163467004
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	49/1963	178/9376	1.3148414202064	CACYBP/JUN/SIRT1/TLE4/MYC/CAMK2D/PRKCA/SIAH1/SFRP1/RYK/PLCB1/SMAD4/FZD6/CTNNB1/BTRC/CBY1/TBL1XR1/FRAT2/PPP3R1/NFATC1/CCND3/CSNK1A1/PPP3CC/CSNK2A2/PPP3CA/PLCB4/SKP1/CUL1/EP300/NFATC3/PSEN1/TLE1/APC/MAPK8/SENP2/TCF7/MAP3K7/ANKRD6/LRP6/FOSL1/PPARD/CCDC88C/GSK3B/INVS/FZD9/DVL3/PLCB3/DVL1/CTBP1	2.18224722168523
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	18/1963	54/9376	1.59212090337918	HES1/WDR48/POLK/FANCL/BRCA2/RPA3/ATR/USP1/FANCF/PMS2/FANCA/FANCC/FAN1/RAD51C/RMI1/REV1/ERCC4/FANCG	2.24544029346615
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	32/1963	110/9376	1.38948733385819	HSP90AA1/HSP90AB1/IGF1/CDC25B/GNAI3/RPS6KA3/PIK3CA/CDK2/ADCY4/BRAF/CDC23/CPEB2/CDC16/ANAPC10/CDC26/KRAS/CDC27/ANAPC16/AKT3/ANAPC5/ANAPC7/MAPK8/ANAPC13/MAPK1/ANAPC1/AKT1/PIK3CB/ADCY6/CCNB1/ANAPC4/PIK3R3/CDK1	2.11442517768798
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1963	98/9376	1.4134134550407	VAV3/MARCKSL1/CFL2/PRKCA/PIK3CA/CDC42/LIMK2/DOCK1/ARPC5L/ARF6/WASF3/ARPC1B/ARPC1A/PLA2G4C/CRK/ACTR2/AKT3/MARCKS/PLD1/ACTR3/MAPK1/AKT1/PIK3CB/ASAP2/ASAP1/ACTR3C/ARPC3/PIK3R3/WASF1	2.11699215602153
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	26/1963	86/9376	1.4440166332974	CDKN1B/NCK1/JUN/SOS2/GAB1/MYC/CAMK2D/PRKCA/PIK3CA/SOS1/PTK2/BRAF/KRAS/CRK/AKT3/MAPK8/NCK2/MAPK1/AKT1/PIK3CB/ELK1/GSK3B/CDKN1A/SHC1/PIK3R3/SHC2	2.1285771516389
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	118/1963	480/9376	1.17418916624215	PPID/HSPA5/DDIT3/XBP1/CASP7/TBK1/PSMA2/CASP3/SDHD/NRBF2/CAMK2D/PRKCA/RAB8A/MAP1LC3B/EIF2S1/RAB5A/PLCB1/CYCS/FZD6/SNCAIP/CTNNB1/TANK/APP/PSMD12/PSMC6/NDUFB5/IFT57/UBE2L6/BID/NDUFC2/ATXN3/FRAT2/BRAF/SOD1/MFN1/PPP3R1/MT-ND6/CSNK1A1/NDUFA5/TNFRSF1A/NDUFB3/ATP2A2/PIK3R4/SNCA/PPP3CC/VDAC3/CSNK2A2/PPP3CA/DERL1/PLCB4/CAPN2/MAP2K6/UBE2J2/VAPB/NDUFV2/UBE2J1/SLC25A5/KRAS/ATG101/HTT/ATP5F1C/PSMA3/NDUFA8/PSMB2/NFKB1/UBE2G1/PSMD11/PSEN1/RAB1A/PIK3C3/ATXN2/APC/ZFYVE1/ACTR10/MAPK8/PSMA5/ATXN2L/NDUFB8/ATG2B/HTRA2/VCP/APAF1/NDUFC1/NDUFS4/MAPK1/SPG11/ITPR1/PSMA1/UBB/TRAF2/GRIN2B/C9orf72/HSD17B10/UQCRC2/LRP6/COX7A2L/ATXN1/ATXN1L/VDAC2/ALS2/NDUFB6/FUS/GSK3B/VDAC1/UQCRH/NDUFB4/CALM1/PSMA6/FZD9/DVL3/NOX4/PLCB3/OPTN/DVL1/UBC/CSF1/SMCR8/DLG4	2.01601221848169
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	49/1963	181/9376	1.29304846849027	HSPD1/MRC1/IFNGR1/NFYB/CASP3/ARHGEF12/CAMK2D/BCL10/IFNGR2/RAB5A/CASP10/TRAF6/CYCS/STAT1/RIPK2/BID/PLK3/TGFB3/PPP3R1/LAMP2/TNFRSF1A/PPP3CC/PPP3CA/CREB1/IRAK4/HSPA9/CLEC4M/EP300/CEBPG/NFKB1/CEBPB/PIK3C3/AKT3/MAPK8/ATP6V0A1/NFYA/TRADD/NFYC/APAF1/MAPK1/CTSS/AKT1/RAB7A/JAK1/MALT1/CALM1/JAK2/IRAK2/IL12A	2.04857403855458
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/1963	44/9376	1.62830546936507	MAN1A1/STT3B/ALG13/TUSC3/MGAT2/MAN2A1/FUT8/OSTC/DDOST/B4GALT1/MGAT4C/HEXA/ALG11/DAD1/MAN1C1	2.14960469195634
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	40/1963	144/9376	1.32676741948265	KLF4/IGF1/ID1/SMAD9/LIF/SMAD1/STAT3/HOXD1/ID3/MYC/PIK3CA/SMAD4/FZD6/SMAD5/CTNNB1/SKIL/KAT6A/SMARCAD1/IL6ST/KRAS/AKT3/APC/PCGF3/TCF7/PCGF5/MAPK1/ZFHX3/AKT1/PIK3CB/BMI1/ACVR2B/JAK1/GSK3B/HOXA1/FZD9/DVL3/JAK2/DVL1/ACVR1B/PIK3R3	2.03339094169608
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	54/1963	203/9376	1.27055953865728	VAV3/IGF1/ITGA2/BIRC2/JUN/SOS2/PGF/HGF/PRKCA/PIK3CA/PTEN/SOS1/PPP1CC/CDC42/DOCK1/PTK2/FLT4/EMP2/CTNNB1/LAMB1/ITGAV/KDR/BRAF/ITGA1/CCND3/COL4A1/CAPN2/ITGA9/RELN/ITGA6/RAP1A/MYL12A/CRK/COL9A3/PPP1CB/AKT3/MYL12B/MAPK8/COL4A5/MAPK1/AKT1/BIRC3/PIK3CB/ELK1/FYN/GSK3B/LAMC2/SHC1/RAP1B/PARVB/PIK3R3/SHC2/ITGA8/ACTN1	2.00541361854532
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	29/1963	99/9376	1.39913655145443	FOS/CDKN1B/IGF1/JUN/SOS2/DLL4/PIK3CA/NOTCH1/SOS1/GNAS/CDKN2C/PTK2/RB1/ADCY4/BRAF/SP1/MDM2/KRAS/AKT3/MAPK8/MAPK1/AKT1/NCOA3/PIK3CB/CDKN1A/SHC1/ADCY6/PIK3R3/SHC2	2.05439574849944
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/1963	38/9376	1.63401882188916	SIRT1/PNP/NT5C2/NADK2/SIRT2/NAMPT/NT5E/NMNAT1/NNT/SIRT5/SIRT7/NNMT/NUDT12	2.01518908531828
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/1963	73/9376	1.43945177565789	GADD45A/SOS2/HGF/STAT3/POLK/PRKCA/PIK3CA/SOS1/RB1/BRAF/GADD45B/KRAS/AKT3/MAPK1/AKT1/EML4/PIK3CB/DDB2/CDKN1A/PIK3R3/FHIT/RARB	1.93958997680792
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/1963	43/9376	1.55509483585874	ALDH2/ACSL3/HADH/ALDH9A1/HADHB/ACADVL/ALDH3A2/ACADM/ECI2/ACAT2/CPT1A/ACSL4/ACSL5/GCDH	1.87732545923817
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/1963	51/9376	1.49846673259217	PRKCA/GNAS/PDIA4/ATP6V1C1/ATP6V1D/KDELR1/ATP6V0A1/ERO1A/TJP1/ATP6V1B2/ARF1/ATP6V1G1/TJP2/SEC61B/SLC12A2/ATP6V1C2	1.83673133318484
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1963	67/9376	1.42577991347389	CAMK2D/PRKCA/RPS6KA3/PPP1CC/PLCB1/BRAF/PPP3R1/PPP3CC/PPP3CA/PLCB4/RAP1A/KRAS/EP300/PPP1CB/MAPK1/ITPR1/GRIN2B/CALM1/RAP1B/PLCB3	1.79978174921391
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/1963	117/9376	1.30635561302907	BRD8/BCL7C/ARID1B/PHF6/EPC2/EPC1/SMARCE1/MBD2/MORF4L2/ARID2/ACTR6/PHF10/ING3/ACTL6A/INO80D/SMARCA5/BRD7/YEATS4/TRRAP/MEAF6/CDK2AP1/MTA2/UCHL5/SS18/DPF2/INO80C/MORF4L1/INO80/BCL7B/MTA3/BICRAL/SS18L1	1.71587449400815
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/1963	44/9376	1.5197517714074	DYNLL1/GNAS/RAB5A/DYNC1I1/RAB11A/NSF/CREB1/AVPR2/CREB5/DYNC1H1/DYNC1LI2/ADCY6/DYNC2H1/AQP3	1.77821282949997
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	20/1963	68/9376	1.40481256180516	SOS2/STAT3/MYC/PIK3CA/SOS1/BRAF/DUSP6/PML/KRAS/IKBKB/NFKB1/AKT3/TCF7/MAPK1/PPARD/AKT1/PIK3CB/PIM2/PIK3R3/RARA	1.72396735464792
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	30/1963	110/9376	1.30264437549206	ID1/SMAD9/TGFBR2/SMAD1/TGIF1/ZFYVE16/LEMD3/ID3/BMP2/MYC/SIN3A/SMAD4/SMAD5/SKIL/SP1/TGFB3/PPP2CB/ZFYVE9/SKP1/CUL1/EP300/PPP2CA/MAPK1/TFDP1/PPP2R1B/ACVR2B/HFE/NEO1/ACVR1B/RBL1	1.64297740079796
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	89/1963	368/9376	1.15515293804957	HSPA5/DDIT3/HNRNPA2B1/SRSF7/XBP1/TBK1/HNRNPA3/PSMA2/CASP3/SRSF3/SDHD/NRBF2/RAB8A/MAP1LC3B/EIF2S1/RAB5A/CYCS/SETX/NUP54/TANK/PSMD12/PSMC6/NDUFB5/BID/NDUFC2/NXT1/SOD1/PPP3R1/MT-ND6/UBQLN2/NDUFA5/TNFRSF1A/NUP58/NDUFB3/NUP98/PIK3R4/PPP3CC/PPP3CA/DERL1/MAP2K6/NUP153/VAPB/NDUFV2/ATG101/ATP5F1C/UBQLN1/PSMA3/NDUFA8/PSMB2/PSMD11/ANXA7/RAB1A/PIK3C3/CASP1/NCBP1/ATXN2/ACTR10/RANBP2/HNRNPA1/PSMA5/ATXN2L/NDUFB8/ATG2B/VCP/APAF1/NDUFC1/NDUFS4/NXF1/SPG11/PSMA1/TRAF2/GRIN2B/C9orf72/UQCRC2/COX7A2L/NUP107/NUP133/ALS2/NDUFB6/FUS/VDAC1/UQCRH/NDUFB4/PSMA6/NUP205/OPTN/NUP35/SMCR8/NUP88	1.56249455479227
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	13/1963	41/9376	1.514456469068	ATM/ABRAXAS1/TOPBP1/MRE11/BRCA2/BARD1/NBN/RPA3/POLD3/RAD50/RAD51B/BABAM1/RAD51C	1.69876063182532
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	57/1963	227/9376	1.19935098888916	FOS/GSTM3/NFKBIA/MGST2/JUN/SOS2/AHR/SOD2/PRKD3/HGF/SDHD/EPHX4/PIK3CA/PTEN/SOS1/EPHX1/PTK2/NDUFB5/NDUFC2/BRAF/SOD1/ACP1/MT-ND6/NDUFA5/NDUFB3/VDAC3/NDUFV2/SLC25A5/KRAS/IKBKB/PTPN11/ATP5F1C/NDUFA8/NFKB1/AKT3/PLD1/MAPK8/HIF1A/NDUFB8/MGST3/NDUFC1/NDUFS4/AKR1C3/MAPK1/UQCRC2/AKT1/COX7A2L/VDAC2/PIK3CB/NDUFB6/VDAC1/UQCRH/NDUFB4/EPHX2/NOX4/GSTO1/PIK3R3	1.56456387030135
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1963	57/9376	1.42452922933927	ACSL3/HSD17B4/SCP2/HADH/HADHB/ACADVL/ELOVL1/HSD17B12/ACADM/ELOVL5/ACAT2/CPT1A/ACSL4/HACD2/HACD3/ACSL5/CBR4	1.65428052560319
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	39/1963	150/9376	1.24185430463576	CDKN1B/GADD45A/TGFBR2/SOS2/GAB1/HGF/POLK/MYC/PIK3CA/CDK2/SOS1/SMAD4/FZD6/CTNNB1/RB1/FRAT2/BRAF/TGFB3/CSNK1A1/GADD45B/KRAS/CTNNA1/AKT3/APC/TCF7/MAPK1/LRP6/AKT1/PIK3CB/DDB2/GSK3B/CDKN1A/SHC1/FZD9/DVL3/DVL1/PIK3R3/SHC2/RARB	1.5365316622778
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	31/1963	116/9376	1.27644175874365	GLS/GNAI3/GNB4/SLC38A2/PRKCA/HOMER3/GNAS/PLCB1/SHANK3/ADCY4/GNG12/PPP3R1/SLC38A1/PPP3CC/PPP3CA/PLCB4/PLA2G4C/PLD1/MAPK1/ITPR1/GRIN2B/GNGT2/SLC17A7/TRPC1/GNG11/ADCY6/GNG10/GNG5/GRIK1/PLCB3/DLG4	1.5416150324957
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/1963	34/9376	1.54529381798568	POLR1D/CRCP/POLR2K/POLR2M/POLR3K/POLR2H/POLR2B/POLR2C/POLR2D/POLR3F/POLR3A	1.63907523711274
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	25/1963	91/9376	1.31218755773009	VAV3/FOS/NFKBIA/RASGRP3/JUN/SOS2/BCL10/PIK3CA/SOS1/PPP3R1/NFATC1/PPP3CC/PPP3CA/KRAS/IKBKB/NFKB1/NFATC3/AKT3/NFKBIE/MAPK1/AKT1/PIK3CB/GSK3B/MALT1/PIK3R3	1.53990567781258
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/1963	12/9376	1.99015112922398	CD46/NCAM1/ASGR1/CLEC4M/NPC1	1.76607928089893
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	21/1963	75/9376	1.33738155883851	HSPA5/ATF2/PRKCA/GNAS/PLCB1/PDIA4/SLC26A4/ADCY4/HSP90B1/PLCB4/CANX/CREB1/ASGR1/ATP1A1/CREB5/ITPR1/ATF6B/ADCY6/GSR/PLCB3/TTF2	1.50950980374268
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	29/1963	109/9376	1.27077539994485	FOS/NFKBIA/IRF7/TBK1/JUN/LY96/MAP3K8/PIK3CA/TRAF6/STAT1/IRF9/TLR5/MAP2K6/IRAK4/IFNAR1/IKBKB/NFKB1/RIPK1/AKT3/MAPK8/MAP3K7/CXCL8/MAPK1/AKT1/PIK3CB/JAK1/TLR3/PIK3R3/IL12A	1.46319315696912
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	92/1963	388/9376	1.1325396116821	PPID/DDIT3/EIF2AK2/XBP1/CASP7/PSMA2/CASP3/ADAM17/SDHD/NRBF2/PIK3CA/RTN3/EIF2S1/PLCB1/CYCS/FZD6/CTNNB1/APP/PSMD12/SLC39A1/PSMC6/NDUFB5/BID/NDUFC2/NAE1/FRAT2/BRAF/PPP3R1/MT-ND6/CSNK1A1/NDUFA5/TNFRSF1A/NDUFB3/ATP2A2/PIK3R4/SNCA/PPP3CC/VDAC3/CSNK2A2/PPP3CA/PLCB4/CAPN2/ADAM10/NDUFV2/SLC39A14/SLC25A5/KRAS/ATG101/IKBKB/ATP5F1C/PSMA3/NDUFA8/PSMB2/NFKB1/PSMD11/PSEN1/PIK3C3/AKT3/APC/MAPK8/PSMA5/NDUFB8/ATG2B/APAF1/NDUFC1/NDUFS4/MAPK1/ITPR1/PSMA1/TRAF2/GRIN2B/HSD17B10/UQCRC2/LRP6/AKT1/COX7A2L/VDAC2/PIK3CB/NDUFB6/GSK3B/VDAC1/UQCRH/NDUFB4/CALM1/PSMA6/FZD9/DVL3/NOX4/PLCB3/DVL1/PIK3R3/CSF1	1.37207803738297
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1963	93/9376	1.28396847046708	JUN/SOS2/CAMK2D/PRKCA/SOS1/GNAS/CDC42/PLCB1/ADCY4/MAP3K1/MAP3K4/PLCB4/MAP2K6/KRAS/PLA2G4C/MAPK7/PLD1/MAPK8/MAPK1/ITPR1/ELK1/CALM1/ADCY6/PLCB3/EGR1	1.41617267100844
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	46/1963	184/9376	1.19409067753439	EFNA5/PARD6G/SEMA6A/NCK1/EFNA1/GNAI3/ARHGEF12/SRGAP2/CFL2/CAMK2D/PRKCA/PIK3CA/RYK/CDC42/LIMK2/PTK2/PPP3R1/SSH2/SEMA4D/SEMA3A/PPP3CC/PPP3CA/TRPC6/MYL12A/KRAS/PTPN11/NFATC3/MYL12B/EPHB4/NCK2/SEMA3D/MAPK1/SEMA6C/NTN1/SSH1/TRPC1/PIK3CB/EFNA4/FYN/GSK3B/SEMA4F/LRIG2/NEO1/EPHB1/PIK3R3/NGEF	1.36822451531918
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1963	20/9376	1.67172694854814	LBR/MSMO1/HSD17B7/LIPA/EBP/SC5D/CYP51A1	1.54743156329527
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/1963	20/9376	1.67172694854814	CMAS/CYB5RL/NANP/GNE/GMDS/UAP1/TGDS	1.54743156329527
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/1963	60/9376	1.3533027678723	IGF1/GNAI3/PRKCA/GNAS/PLCB1/BRAF/PLCB4/PPP2CB/KRAS/PLA2G4C/PPP2CA/PRKG1/GNA13/MAPK1/ITPR1/PPP2R1B/PLCB3	1.41272201511599
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/1963	107/9376	1.24988930732571	ATF2/SIRT1/CAMK2D/PPP4R3B/GNAS/PLCB1/PPP3R1/PPP3CC/PPP3CA/PLCB4/CREB1/PPP4R3A/PRKAA1/EP300/PRKAA2/CREB5/AKT3/CPT1A/PRKAG2/PPP4C/ACACB/ITPR1/PDHB/AKT1/CALM1/CRTC2/PLCB3/SIK1	1.33774060293323
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	52/1963	212/9376	1.17156066475072	EFNA5/VAV3/IGF1/PARD6G/RASGRP3/ID1/EFNA1/PGF/PRKD3/GNAI3/HGF/PRKCA/PIK3CA/GNAS/CDC42/PLCB1/RALB/FLT4/CTNNB1/ADCY4/RAPGEF5/AFDN/KDR/BRAF/CTNND1/PLCB4/MAP2K6/RAP1A/KRAS/KRIT1/CRK/RALGDS/AKT3/RAPGEF2/SIPA1/ARAP3/TEK/MAPK1/DOCK4/PLCE1/GRIN2B/AKT1/PIK3CB/FARP2/EFNA4/CALM1/RAP1B/ADCY6/PLCB3/PIK3R3/CSF1/RAPGEF4	1.30014532434765
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/1963	36/9376	1.45944416143092	PRIM2/MCM3/POLE4/RPA3/POLD3/PRIM1/PCNA/RFC4/DNA2/MCM6/RFC5	1.42121354243707
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	27/1963	103/9376	1.25205624440499	CXCL2/CXCL1/CASP3/PRKCA/PIK3CA/GNAS/RAB5A/PLCB1/PTK2/LAMB1/TGFB3/COL4A1/PLCB4/NFKB1/PRDX1/SERPINB9/COL4A5/ARG2/CXCL8/RAB7A/CXCL3/PIK3CB/LAMC2/PLCB3/PIK3R3/IL12A/ACTN1	1.32359382222721
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1963	78/9376	1.28594380657549	FOS/CASP7/JUN/CASP3/LY96/GNAI3/IRF8/CFL2/TRAF6/IRF1/IRAK4/PYCARD/NFKB1/CASP1/MAPK8/CXCL8/MAPK1/CALM1/C1R/NOD1/IL12A	1.30491436701539
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1963	21/9376	1.59212090337918	ALDH2/ALDH3A2/PANK3/CSAD/DPYD/AASDHPPT/PANK2	1.397806103377
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	22/1963	83/9376	1.26602385087983	NFKBIA/MLKL/CASP7/IRF7/TBK1/CASP3/POLR1D/G3BP1/POLR2K/IFI16/ADAR/POLR3K/POLR2H/CGAS/PYCARD/IKBKB/NFKB1/ZCCHC3/RIPK1/CASP1/POLR3F/POLR3A	1.25265201527154
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	37/1963	149/9376	1.18607664614154	SOS2/GAB1/PRKCA/PIK3CA/SOS1/GNAS/PLCB1/RALB/LPAR6/ADCY4/ARF6/AGPAT5/PLCB4/KRAS/PLA2G4C/PTPN11/RALGDS/AVPR2/AKT3/PLD1/DGKE/GNA13/CXCL8/MAPK1/AKT1/CYTH2/PIK3CB/DGKH/ARF1/FYN/PIK3CG/SHC1/ADCY6/PLCB3/PIK3R3/SHC2/RAPGEF4	1.17815798635861
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1963	14/9376	1.70584382504912	FUT8/B3GNT7/B4GALT1/B4GALT4/B3GNT2	1.35999435930372
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	29/1963	115/9376	1.20447407473034	FOS/GNAI3/GNB4/CAMK2D/PRKCA/PIK3CA/PLCB1/ADCY4/GNG12/PLCB4/CREB1/KRAS/CREB5/AKT3/MAPK1/ITPR1/GNGT2/AKT1/PIK3CB/ACHE/FYN/GNG11/PIK3CG/ADCY6/GNG10/GNG5/JAK2/PLCB3/PIK3R3	1.13529053636797
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	84/1963	362/9376	1.10832725870595	HSP90AA1/HSP90AB1/EFNA5/CDKN1B/IGF1/ITGA2/IL7/PPP2R5A/SOS2/ATF2/EFNA1/PGF/HGF/BCL2L11/GNB4/MYC/PRKCA/MCL1/PIK3CA/CDK2/PTEN/SOS1/PPP2R3C/LPAR6/SGK3/PTK2/FLT4/LAMB1/ITGAV/KDR/GNG12/PPP2R5C/ITGA1/CCND3/COL4A1/HSP90B1/ITGA9/MDM2/PPP2CB/RBL2/CREB1/CDC37/RELN/YWHAG/EIF4B/ITGA6/PPP2R2D/IFNAR1/PRKAA1/KRAS/IKBKB/NFKB1/COL9A3/PPP2CA/PRKAA2/CREB5/PKN2/YWHAQ/AKT3/COL4A5/TEK/MAPK1/PPP2R1B/GNGT2/AKT1/PIK3CB/YWHAZ/JAK1/EFNA4/GSK3B/LAMC2/ATF6B/GNG11/CRTC2/CDKN1A/PIK3CG/STK11/GNG10/GNG5/JAK2/PPP2R5B/PIK3R3/ITGA8/CSF1	1.08163828156667
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1963	18/9376	1.59212090337918	LMBRD1/ABCD4/MMADHC/ZNF143/PRDX1/THAP11	1.29390953459725
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	38/1963	155/9376	1.17097924506598	CDKN1B/ATF2/AHR/GNAI3/RASD1/CAMK2D/CDK2/GNAS/PLCB1/FZD6/CDKN2C/CTNNB1/RB1/ADCY4/BRAF/SP1/PLCB4/CREB1/RAP1A/CREB5/APC/TCF7/MAPK1/ITPR1/RBBP5/GSK3B/ATF6B/CDKN1A/RAP1B/FH/ARMC5/ADCY6/FZD9/KMT2A/DVL3/PLCB3/DVL1/PDE8A	1.10450839512892
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1963	30/9376	1.43290881304126	PIGK/PIGA/PIGF/PIGG/PIGH/PIGN/PIGP/PIGC/PIGM	1.22206119573001
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/1963	85/9376	1.23623505438854	CMPK2/NTPCR/NT5C3A/PNP/NT5C2/CMPK1/GMPR2/DCK/GMPS/NT5E/AK6/DUT/ENTPD4/NME7/NT5C3B/DTYMK/LACC1/RRM2B/CTPS2/UCKL1/ADSL/TYMS	1.12582622992465
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	55/1963	232/9376	1.13232736662744	VAV3/ITGA2/ARHGEF7/SOS2/MYH10/ARHGEF12/CFL2/PIK3CA/SOS1/CYFIP1/PPP1CC/CDC42/LIMK2/DOCK1/PTK2/WASL/ARPC5L/ITGAV/NCKAP1/GNG12/BRAF/ITGA1/SSH2/PIP4K2A/ARPC1B/ARPC1A/ITGA9/ITGA6/MYL12A/KRAS/CRK/ACTR2/PPP1CB/AKT3/MSN/APC/MYL12B/ARHGEF6/BAIAP2/GNA13/ACTR3/MAPK1/AKT1/BRK1/SSH1/PIK3CB/ABI2/PIKFYVE/DIAPH2/ACTR3C/ARPC3/PIK3R3/ITGA8/WASF1/ACTN1	1.05020562873647
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	13/1963	47/9376	1.32112160067634	ALDH2/ACYP1/ALDH9A1/ACYP2/ALDH3A2/ACAT2/MDH1/HAGH/ACACB/PDHB/ME2/DLD/FH	1.13566355870752
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	25/1963	99/9376	1.20615219952968	FOS/JUN/SOS2/PRKCA/PIK3CA/SOS1/SP1/CHPT1/WASF3/CHKA/KRAS/PLA2G4C/LYPLA1/RALGDS/AKT3/PLD1/MAPK8/HIF1A/DGKE/MAPK1/AKT1/PIK3CB/DGKH/PIK3R3/WASF1	1.06108598852777
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1963	60/9376	1.27369672270335	PRKCA/PIK3CA/CDC42/PTK2/KDR/PPP3R1/PPP3CC/PPP3CA/KRAS/PLA2G4C/AKT3/MAPK1/AKT1/PIK3CB/PIK3R3/SHC2	1.094408028436
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	18/1963	69/9376	1.24600766351414	FOS/JUN/ATF2/SIRT1/CAMK2D/PRKCA/GNAS/PPP1CC/PPP3R1/FOSB/PPP3CC/PPP3CA/CREB1/PPP1CB/CREB5/GRIN2B/ATF6B/CALM1	1.05540005531038
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/1963	31/9376	1.38668594810445	ALDH2/ALDH9A1/HIBCH/ALDH3A2/CNDP2/CSAD/DPYD/GAD1/ALDH6A1	1.10968156803254
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1963	31/9376	1.38668594810445	HSPA5/SRP9/SRP54/SPCS3/SRPRB/SEC11A/SRPRA/SPCS2/SEC61B	1.10968156803254
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	27/1963	109/9376	1.18313571719003	HSP90AA1/HSP90AB1/FOS/NFKBIA/TGFBR2/IFNGR1/JUN/AHR/STAT3/IFNGR2/SMAD4/STAT1/PPP3R1/NFATC1/PPP3CC/PPP3CA/IL6ST/IKBKB/NFKB1/NFATC3/MAPK8/HIF1A/NFKBIE/MAPK1/JAK1/JAK2/RARA	0.989613267097623
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	37/1963	154/9376	1.14756766412396	GCH1/ALDH2/CMPK2/SPR/RFK/MOCS2/DHODH/NADK2/MAT2A/CMPK1/GPHN/RDH11/CPOX/AK6/NMNAT1/ALDH3A2/MAT2B/ALAS1/AFMID/PANK3/PTS/NME7/GCLM/GCLC/LIPT1/DLD/CTPS2/PHOSPHO2/PANK2/MTHFD2L/COX10/ADSL/COX15/TPK1/UMPS/EARS2/NFS1	0.950140416455046
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/1963	97/9376	1.18178046436393	FOS/GNAI3/RASD1/GNB4/CAMK2D/PRKCA/GNAS/PLCB1/ADCY4/GNG12/PLCB4/CREB1/PRKG1/PER1/MAPK1/ITPR1/GRIN2B/GNGT2/CALM1/GNG11/ADCY6/GNG10/GNG5/PLCB3	0.926043262233703
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	48/1963	205/9376	1.11836785408099	CD36/TGFBR2/TBC1D4/SDHD/CAMK2D/PRKCA/PIK3CA/PTEN/PPP1CC/PLCB1/NDUFB5/NDUFC2/SP1/TGFB3/MT-ND6/NDUFA5/NDUFB3/ATP2A2/VDAC3/PLCB4/MPC2/NDUFV2/SLC25A5/ATP5F1C/NDUFA8/NFKB1/PPP1CB/AKT3/MPC1/MAPK8/PDK4/NDUFB8/NDUFC1/NDUFS4/UQCRC2/PDHB/AKT1/COX7A2L/VDAC2/PIK3CB/NDUFB6/GSK3B/VDAC1/UQCRH/NDUFB4/GSR/PLCB3/PIK3R3	0.881761527452996
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/1963	32/9376	1.34335201222618	SUCLA2/ECHDC1/HIBCH/PCCA/DBT/ACACB/SUCLG2/DLD/ALDH6A1	1.00114494568131
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	28/1963	115/9376	1.16294048594653	FOS/JUND/ATF2/GNAI3/PRKCA/MEF2C/GNAS/PLCB1/ADCY4/BRAF/SP1/MMP16/PLCB4/CREB1/ARHGEF11/CREB5/PLD1/GNA13/MAPK1/ITPR1/LRP6/ATF6B/CDKN1A/ADCY6/STK39/PLCB3/WNK3/EGR1	0.904685799068934
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/1963	93/9376	1.18125099282972	FOS/NFKBIA/IFNGR1/JUN/DLL4/MAML2/NOTCH1/IFNGR2/MAF/STAT1/PPP3R1/NFATC1/PPP3CC/PPP3CA/IKBKB/NFKB1/NFATC3/MAPK8/NFKBIE/MAPK1/JAK1/JAK2/IL12A	0.903912685152647
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/1963	28/9376	1.3646750600393	GCNT2/ST3GAL6/B3GNT5/ST8SIA1/A4GALT/B4GALT1/B4GALT4/B3GNT2	0.994430680598035
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1963	54/9376	1.23831625818381	BHMT2/AMD1/MPST/CISD1/MAT2A/MAT2B/APIP/MDH1/LACC1/GCLM/GCLC/ADI1/MRI1/ENOPH1	0.903742674274955
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1963	59/9376	1.21432950257734	GSTM3/GGT5/MGST2/IDH1/TXNDC12/GGCT/GCLM/MGST3/GCLC/LAP3/RRM2B/LANCL1/PRDX6/GSR/GSTO1	0.849803865151036
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1963	46/9376	1.24600766351414	PSMA2/PSMD12/PSMC6/PSMB8/PSMA3/PSMB2/PSMD11/PSMB9/PSMA5/PSMA1/PSME4/PSMA6	0.860667726800541
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/1963	29/9376	1.31761729934829	SAV1/STK3/TEAD2/MOB1A/YAP1/WWTR1/LATS1/FAT4	0.881486801984224
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1963	42/9376	1.25095213836936	ACSL3/MAP1LC3B/SAT2/ATG5/VDAC3/SLC39A14/ACSL4/GCLM/GCLC/VDAC2/ACSL5	0.838745948840561
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1963	73/9376	1.17773327099282	IGF1/GADD45A/HGF/POLK/PIK3CA/PTEN/RB1/BRAF/MDM2/GADD45B/KRAS/AKT3/MAPK1/AKT1/PIK3CB/DDB2/CDKN1A/PIK3R3	0.784453926592682
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/1963	82/9376	1.16496651466769	HSPA1A/HSPA1B/HSP90AA1/HSP90AB1/HSPA8/HSPA5/HSPA4/CALR/NFYB/HSPA6/B2M/TAP1/PDIA3/CANX/CREB1/HLA-F/TAP2/NFYA/NFYC/CTSS	0.772058447175921
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1963	17/9376	1.40481256180516	MYH10/NRP2/PCDH9/LAMP2/CLEC4M	0.859631865128309
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	62/1963	275/9376	1.0768526837401	HSPA1A/HSPA1B/HSPA8/HSPA5/STIP1/DDIT3/ATF2/HSPA6/PSMA2/CASP3/SDHD/PIK3CA/NOTCH1/EIF2S1/CYCS/PSMD12/PSMC6/NDUFB5/NDUFC2/SOD1/PPP3R1/MT-ND6/NCAM1/NDUFA5/NDUFB3/PPP3CC/VDAC3/CSNK2A2/PPP3CA/CREB1/NDUFV2/SLC25A5/ATP5F1C/PSMA3/NDUFA8/PSMB2/PSMD11/CREB5/MAPK8/PSMA5/NDUFB8/APAF1/NDUFC1/NDUFS4/MAPK1/ITPR1/PSMA1/GRIN2B/UQCRC2/COX7A2L/VDAC2/PIK3CB/NDUFB6/FYN/GSK3B/VDAC1/UQCRH/NDUFB4/ATF6B/PSMA6/PIK3R3/EGR1	0.665624985388112
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	16/1963	65/9376	1.17572005172616	PRKCA/PIK3CA/PLCB1/KCNN3/PLCB4/KRAS/AKT3/GABBR1/MAPK1/ITPR1/AKT1/TRPC1/PIK3CB/KCNN2/PLCB3/PIK3R3	0.731524077899488
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	69/1963	308/9376	1.0700293084399	TBPL1/PSMA2/CASP3/SOD2/SDHD/NRBF2/SIN3A/BBC3/PLCB1/CYCS/POLR2K/PSMD12/PSMC6/NDUFB5/IFT57/NDUFC2/SOD1/SP1/MT-ND6/PPARG/NDUFA5/NDUFB3/PIK3R4/POLR2H/VDAC3/PLCB4/CREB1/NDUFV2/POLR2B/SLC25A5/ATG101/HTT/POLR2C/CLTC/ATP5F1C/EP300/PSMA3/NDUFA8/PSMB2/PSMD11/PIK3C3/CREB5/ACTR10/MAPK8/PSMA5/NDUFB8/ATG2B/APAF1/NDUFC1/NDUFS4/ITPR1/PSMA1/TRAF2/GRIN2B/UQCRC2/COX7A2L/VDAC2/NDUFB6/VDAC1/TAF4/UQCRH/NDUFB4/PSMA6/AP2M1/POLR2D/PLCB3/CLTA/DLG4/NRF1	0.643055160889938
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1963	13/9376	1.46965006465771	MRE11/PRKDC/RAD50/DCLRE1C	0.871941480904962
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	44/1963	193/9376	1.08891170593809	VAV3/NFKBIA/CXCL2/CXCL1/SOS2/GNAI3/STAT3/GNB4/PIK3CA/SOS1/CDC42/PLCB1/STAT1/CCL21/PTK2/ADCY4/GNG12/BRAF/PLCB4/RAP1A/KRAS/IKBKB/CRK/NFKB1/AKT3/CXCL8/MAPK1/GNGT2/AKT1/CXCL3/PIK3CB/FGR/GSK3B/GNG11/PIK3CG/SHC1/RAP1B/ADCY6/GNG10/GNG5/JAK2/PLCB3/PIK3R3/SHC2	0.64223518287282
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	32/1963	138/9376	1.10756236756813	MKNK2/SOCS3/SOS2/SOCS2/PIK3CA/SOS1/PPP1CC/BRAF/PRKAR1A/SOCS4/SOCS1/PRKAA1/KRAS/IKBKB/CRK/PPP1CB/PRKAA2/AKT3/MAPK8/PRKAG2/MAPK1/ACACB/FLOT1/AKT1/PIK3CB/ELK1/GSK3B/CALM1/SHC1/PPP1R3D/PIK3R3/SHC2	0.655027759121184
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	53/1963	235/9376	1.07722222824379	SOS2/ATF2/ACSL3/SDHD/KDM3A/RPS6KA3/SOS1/GNAS/ARID1B/SMARCE1/KDM1A/NDUFB5/ADCY4/NDUFC2/COX11/MT-ND6/PPARG/NDUFA5/NDUFB3/KDM3B/CREB1/NDUFV2/ACTL6A/PRKAA1/KRAS/COA5/ATP5F1C/NDUFA8/COA6/PRKAA2/CREB5/PRKG1/CPT1A/ACSL4/NDUFB8/PRKAG2/NDUFC1/NDUFS4/UQCRC2/COX7A2L/COX14/NDUFAF7/NDUFB6/ACSL5/UQCRH/NDUFB4/FRS2/ADCY6/COX10/NDUFAF1/NDUFAF4/COX15/AKT1S1	0.616919067726374
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/1963	116/9376	1.11173959632512	VAV3/GNAI3/PRKCA/CD99/PIK3CA/CDC42/PTK2/CTNNB1/AFDN/CLDN5/CTNND1/RAP1A/MYL12A/CTNNA1/PTPN11/PECAM1/MSN/MYL12B/SIPA1/F11R/ICAM1/PIK3CB/OCLN/RAP1B/PIK3R3/RAPGEF4/ACTN1	0.623131042873812
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	46/1963	204/9376	1.07702296405062	DDX5/VAV3/IGF1/ITGA2/SOS2/CASP3/GAB1/ARHGEF12/HGF/STAT3/MYC/CAMK2D/PRKCA/SDC4/PIK3CA/SOS1/PPP1CC/CDC42/FZD6/PTK2/CTNNB1/ITGAV/KDR/BRAF/ANK2/MDM2/EIF4B/KRAS/PTPN11/PPP1CB/AKT3/MSN/HPSE/HIF1A/NUDT16L1/MAPK1/ITPR1/PLCE1/AKT1/HCLS1/PIK3CB/ELK1/FRS2/CDKN1A/FZD9/PIK3R3	0.572337333812705
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1963	126/9376	1.09932157614277	ITGA2/GNAI3/ARHGEF12/PIK3CA/GNAS/PPP1CC/PLCB1/SNAP23/ADCY4/PLCB4/RAP1A/MYL12A/PLA2G4C/PPP1CB/PRKG1/AKT3/MYL12B/GNA13/MAPK1/ITPR1/AKT1/PIK3CB/FYN/STIM1/PIK3CG/RAP1B/ADCY6/PLCB3/PIK3R3	0.577572885623949
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	32/1963	140/9376	1.09174004803144	KLF2/GNAI3/GNB4/MEF2C/MAP1LC3B/PLCB1/SMAD4/ADCY4/GNG12/PIK3R4/PLCB4/PRKAA1/KRAS/PRKAA2/PIK3C3/AKT3/PRKAG2/GNA13/PLAT/MAPK1/ITPR1/GNGT2/AKT1/CALM1/GNG11/PIK3CG/ADCY6/GNG10/GNG5/PLCB3/NRF1/EGR1	0.562768534048292
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1963	18/9376	1.32676741948265	ACSL3/ACSL4/ACACB/ACSL5/CBR4	0.714055993043677
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	12/1963	49/9376	1.16972148003368	OGT/C1GALT1C1/ST6GAL1/GALNT18/GALNT7/GXYLT1/B4GALT1/GALNT10/B3GLCT/POGLUT1/XXYLT1/FUT10	0.612932499987764
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1963	49/9376	1.16972148003368	JUN/ATF2/GNAI3/GNAS/FOSB/CREB1/NFKB1/CREB5/GRIN2B/ATF6B/RGS9/DLG4	0.612932499987764
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	53/1963	238/9376	1.06364379679534	OAS1/MX1/FOS/OAS2/NFKBIA/EIF2AK2/TBK1/JUN/RPS21/RPL37/RPL26/ADAM17/STAT3/RPL36A/MX2/PRKCA/RPS10/PIK3CA/TRAF6/STAT1/IRF9/IFIH1/ADAR/OAS3/TNFRSF1A/RPL22L1/CGAS/RSL24D1/IRAK4/IFNAR1/IL6ST/RPS13/IKBKB/NFKB1/CASP1/RPS23/RPS15A/MAPK8/MAP3K7/CXCL8/ISG15/MAPK1/RPS7/RPL30/PIK3CB/JAK1/RPL14/C1R/RPL39/RPL32/TLR3/PIK3R3/IL12A	0.511761687822534
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1963	27/9376	1.23831625818381	HSD17B4/SCP2/ELOVL1/HSD17B12/ELOVL5/HACD2/HACD3	0.638119125730387
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	24/1963	104/9376	1.10223754849328	ETNK1/CHPT1/AGPAT5/LPIN2/CDS2/LPGAT1/CHKA/PLA2G4C/LYPLA1/CEPT1/PGS1/GPAT3/PLD1/MBOAT2/SAMD8/DGKE/PLA2G15/SGMS1/ACHE/DGKH/GPAM/GPD1L/SELENOI/LPCAT4	0.539497173012704
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/1963	155/9376	1.07853351519235	CD36/CALR/ITGA2/MRC1/SEC22B/STX12/RAB5A/DYNC1I1/TAP1/ITGAV/ATP6V1C1/VAMP3/COLEC12/STX7/LAMP2/RILP/M6PR/ATP6V1D/CANX/CLEC4M/HLA-F/PIK3C3/TAP2/ATP6V0A1/DYNC1H1/CTSS/DYNC1LI2/RAB7A/ATP6V1B2/ATP6V1G1/C1R/PIKFYVE/DYNC2H1/SEC61B/ATP6V1C2	0.507318457251707
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1963	41/9376	1.16496651466769	MYC/RB1/BRAF/MDM2/DAPK1/KRAS/CXCL8/MAPK1/CDKN1A/DAPK2	0.544727566930196
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1963	10/9376	1.43290881304126	MPST/SQOR/ETHE1	0.704803640032781
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1963	110/9376	1.08553697957671	MKNK2/CDKN1B/IGF1/IFNGR1/STAT3/CAMK2D/PRKCA/PIK3CA/CUL2/IFNGR2/VHL/EP300/NFKB1/AKT3/HIF1A/TEK/MAPK1/PDHB/AKT1/EGLN3/PIK3CB/ELOC/CDKN1A/PFKFB3/PIK3R3	0.464357958572888
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	37/1963	166/9376	1.06461096551259	ATF2/EDNRB/GNAI3/MEF2C/PPP1CC/PLCB1/ADCY4/PPP3R1/NFATC1/ATP2A2/PPP3CC/VDAC3/PPP3CA/PLCB4/CREB1/TRPC6/SLC25A5/ADRB2/ATP1A1/PPP1CB/NFATC3/CREB5/PRKG1/AKT3/GTF2I/GNA13/MAPK1/ITPR1/AKT1/VDAC2/VDAC1/ATF6B/CALM1/PIK3CG/ADCY6/PDE2A/PLCB3	0.432194511903227
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1963	19/9376	1.25693755529935	DBT/DLST/PDHB/LIPT1/DLD	0.576879174744291
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1963	37/9376	1.16181795651994	CMAS/GALK2/GNPNAT1/NANP/GNE/PGM1/GMDS/UAP1/TGDS	0.507488464288065
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1963	28/9376	1.19409067753439	HADH/HADHB/ELOVL1/HSD17B12/ELOVL5/HACD2/HACD3	0.529264942158243
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1963	28/9376	1.19409067753439	GCH1/PCBD1/SPR/MOCS2/GPHN/PTS/AKR1C3	0.529264942158243
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1963	33/9376	1.1579061115485	IDH1/ACO1/DBT/DLST/IDH3A/PDHB/DLD/NAGS	0.467586024890634
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1963	15/9376	1.27369672270335	ST8SIA1/ST6GALNAC3/HEXA/SLC33A1	0.545887175995939
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1963	15/9376	1.27369672270335	NTPCR/ACP1/TPK1/NFS1	0.545887175995939
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	37/1963	168/9376	1.05193702544696	IL7/LIF/IFNGR1/SOCS3/SOS2/STAT3/SOCS2/MYC/STAM2/MCL1/PIK3CA/IFNGR2/SOS1/FHL1/STAT1/IRF9/CCND3/SOCS4/SOCS1/IFNAR1/IL6ST/PTPN11/PIAS1/EP300/PIAS2/AKT3/SOCS6/IL15RA/AKT1/LEPR/PIK3CB/STAM/JAK1/CDKN1A/JAK2/PIK3R3/IL12A	0.349540776316503
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1963	47/9376	1.11787212364921	SOCS3/SOCS2/PIK3CA/SOCS4/SOCS1/IKBKB/MAPK8/MAPK1/MAFA/PIK3CB/PIK3R3	0.416861011946679
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1963	154/9376	1.05452163730309	PPP2R5A/ATF2/GNAI3/SCN1B/CAMK2D/PRKCA/GNAS/PPP1CC/PLCB1/PPP2R3C/ADCY4/PPP2R5C/ATP2A2/PLCB4/PPP2CB/CREB1/PPP2R2D/ADRB2/ATP1A1/PPP1CB/PPP2CA/CREB5/AKT3/MAPK1/PPP2R1B/AKT1/TPM4/ATF6B/CALM1/PIK3CG/ADCY6/PLCB3/PPP2R5B/RAPGEF4	0.351047172024481
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1963	38/9376	1.13124379976942	IGF1/PRKCA/PIK3CA/KRAS/ATP1A1/NR3C2/MAPK1/PIK3CB/PIK3R3	0.417150191256098
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1963	52/9376	1.10223754849328	CD36/MYLIP/STARD3/STARD3NL/VDAC3/VAPA/VAPB/LIPA/NPC1/VDAC2/VDAC1/LIPC	0.38041685823765
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	47/1963	217/9376	1.03451173906205	HSP90AA1/HSP90AB1/PTGES3/FOS/KLF4/GSTM3/MGST2/JUN/SOS2/ATF2/AHR/GNAI3/DLL4/STAT3/KPNA4/MYC/PRKCA/EPHX4/RPS6KA3/PIK3CA/SOS1/GNAS/EPHX1/RB1/ADCY4/CCND3/PAQR8/HSP90B1/KPNA3/CREB1/BCL6/KRAS/ADRB2/KPNA5/NFKB1/CREB5/AKT3/MGST3/MAPK1/AKT1/PIK3CB/ATF6B/ADCY6/EPHX2/GSTO1/JAK2/PIK3R3	0.264680209357526
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1963	16/9376	1.19409067753439	ST8SIA1/A4GALT/GLA/HEXA	0.399830141810026
NA	NA	hsa04517	IgSF CAM signaling	64/1963	299/9376	1.02236526237058	VAV3/PARD6G/MPDZ/NCK1/MYH10/NRP2/SRGAP2/DYNLL1/PRKCA/NECTIN3/PIK3CA/CDC42/TRAF6/PTK2/CTNNB1/WASL/APP/ARPC5L/ARF6/AFDN/KDR/SPTAN1/ANK2/MTSS1/NCAM1/ARPC1B/ARPC1A/CD2AP/CASK/TRPC6/RAP1A/MYL12A/CLEC4M/PTPN11/ACTR2/EPB41L2/AKT3/MSN/MYL12B/RAPGEF2/MAPK8/ERC1/F11R/TJP1/NCK2/BAIAP2/ACTR3/MAPK1/NTN1/PMP22/AKT1/ICAM1/SPTBN1/PIK3CB/FYN/GSK3B/RAP1B/CADM4/TJP2/ACTR3C/ARPC3/PIK3R3/TRIO/ACTN1	0.202249385937774
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1963	44/9376	1.08553697957671	PARP4/POLE4/POLD3/PCNA/PARG/POLB/NEIL1/RFC4/POLG/RFC5	0.292645379674457
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1963	63/9376	1.06141393558612	GADD45A/BMP2/POLK/FZD6/CTNNB1/GADD45B/APC/TCF7/DDB2/GSK3B/CDKN1A/FZD9/DVL3/DVL1	0.251675645016833
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1963	101/9376	1.04039583785174	EDNRB/GNAI3/CAMK2D/PRKCA/GNAS/PLCB1/FZD6/CTNNB1/ADCY4/PLCB4/CREB1/KRAS/EP300/TCF7/MAPK1/GSK3B/CALM1/ADCY6/FZD9/DVL3/PLCB3/DVL1	0.210033773945962
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1963	78/9376	1.04100212913254	FOS/NFKBIA/IFNGR1/JUN/MARCKSL1/IFNGR2/TRAF6/STAT1/TGFB3/IRAK4/NFKB1/MAP3K7/MAPK1/ELK1/JAK1/JAK2/IL12A	0.18711462235902
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/1963	268/9376	1.01586818835015	DUSP1/HSPA5/DDIT3/XBP1/PSMA2/CASP3/GNAI3/SDHD/CAMK2D/GNAS/EIF2S1/CYCS/SNCAIP/PSMD12/SLC39A1/PSMC6/NDUFB5/UBE2L6/NDUFC2/SOD1/MFN1/MT-ND6/NDUFA5/NDUFB3/SNCA/VDAC3/UBE2J2/NDUFV2/UBE2J1/SLC39A14/SLC25A5/ATP5F1C/PSMA3/NDUFA8/PSMB2/UBE2G1/PSMD11/MAPK8/PSMA5/NDUFB8/HTRA2/APAF1/NDUFC1/NDUFS4/ITPR1/PSMA1/UBB/UQCRC2/COX7A2L/VDAC2/NDUFB6/VDAC1/UQCRH/NDUFB4/CALM1/PSMA6/UBC	0.135622585895126
NA	NA	hsa04518	Integrin signaling	33/1963	154/9376	1.02350629502947	IGF1/ITGA2/PGF/HGF/PIK3CA/CDC42/PTK2/FLT4/CTNNB1/LAMB1/ITGAV/KDR/ITGA1/CCND3/LIMS1/COL4A1/ITGA9/RELN/ITGA6/COL9A3/AKT3/COL4A5/NCK2/ARHGEF6/AKT1/ICAM1/PIK3CB/GSK3B/LAMC2/PARVB/PIK3R3/ITGA8/ACTN1	0.151349423880959
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1963	154/9376	1.02350629502947	FOS/JUN/GNAI3/CAMK2D/PRKCA/MEF2C/GNAS/PPP1CC/PLCB1/ADCY4/PPP3R1/NFATC1/PPP3CC/PPP3CA/PLCB4/PRKAA1/KRAS/PLA2G4C/PPP1CB/NFATC3/PRKAA2/MAPK7/CAMKK2/PRKAG2/MAPK1/ITPR1/MAP2K5/ELK1/CALM1/CDKN1A/PIK3CG/ADCY6/PLCB3	0.151349423880959
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1963	31/9376	1.07853351519235	ACO1/PCCA/AFMID/ACAT2/MDH1/DLD/PGP	0.225369436642195
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1963	50/9376	1.05079979623026	ALDH2/AMD1/SAT2/ALDH9A1/OAT/P4HA1/ALDH3A2/CNDP2/ARG2/LAP3/AZIN2	0.185330993892415
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	15/1963	69/9376	1.03833971959512	VAV3/SOS2/PRKCA/PIK3CA/SOS1/MAP2K6/KRAS/PLA2G4C/AKT3/MAPK8/MAPK1/AKT1/PIK3CB/FYN/PIK3R3	0.164481632820948
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1963	17/9376	1.12385004944413	GGT5/FMO5/CSAD/GAD1	0.262999370684381
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1963	17/9376	1.12385004944413	SEPHS2/TXNRD1/SEPHS1/SEPSECS	0.262999370684381
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	19/1963	89/9376	1.01967293811925	SOS2/GNAI3/PRKCA/SOS1/GNAS/PLCB1/ADCY4/PLCB4/KRAS/MAPK7/PRKG1/TJP1/GJA1/MAPK1/ITPR1/MAP2K5/ADCY6/PLCB3/CDK1	0.0959566978869698
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	19/1963	89/9376	1.01967293811925	GLS/GABRE/GNAI3/GNB4/SLC38A2/PRKCA/ADCY4/GNG12/GABARAPL2/GPHN/SLC38A1/NSF/GABBR1/GNGT2/GNG11/GAD1/ADCY6/GNG10/GNG5	0.0959566978869698
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/1963	56/9376	1.02350629502947	EFCAB7/SPOP/CUL3/BTRC/EVC/EVC2/CSNK1G3/CSNK1A1/CUL1/GSK3B/CSNK1G2/SPOPL	0.0907860305887555
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	28/1963	133/9376	1.00555004423948	VAV3/IFNGR1/SOS2/CASP3/PRKCA/PIK3CA/IFNGR2/SOS1/TNFRSF10B/BID/BRAF/PPP3R1/NFATC1/PPP3CC/PPP3CA/SH3BP2/IFNAR1/KRAS/TNFSF10/PTPN11/MICB/MAPK1/ICAM1/PIK3CB/FYN/SHC1/PIK3R3/SHC2	0.0331714592319201
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1963	42/9376	1.02350629502947	ALDH2/HADH/ALDH9A1/ALDH3A2/AFMID/ACAT2/DLST/DLD/GCDH	0.0785640236275017
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1963	28/9376	1.02350629502947	ATP6V1C1/ATP6V1D/ATP6V0A1/ATP6V1B2/ATP6V1G1/ATP6V1C2	0.0640992037184523
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1963	38/9376	1.00555004423948	GNPDA2/GALK2/GNPDA1/GNPNAT1/GNE/PGM1/HEXA/UAP1	0.0176404677405541
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1963	53/9376	0.991320562481377	PRKCA/GNAS/PLCB1/RAB11A/PLCB4/CLTC/ATP1A1/AP2M1/ADCY6/PLCB3/CLTA	-0.0326062205447945
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/1963	59/9376	0.971463602061874	GNAI3/PIK3CA/GNAS/ADCY4/ADRB2/ABHD5/PRKG1/AKT3/AKT1/PIK3CB/ADCY6/PIK3R3	-0.113145138553929
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1963	69/9376	0.969117071622111	GNAI3/PDE1A/GNAS/PLCB1/PPP3R1/PPP3CC/PPP3CA/PLCB4/CREB1/ADRB2/ITPR1/CALM1/ADCY6/PLCB3	-0.132491174675529
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1963	55/9376	0.955272542027509	DEGS1/SPTLC2/CERS2/SPTLC1/GALC/SAMD8/NEU1/SGMS1/GLA/HEXA/CERS5	-0.171187912072481
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1963	65/9376	0.955272542027509	ATF2/GNAS/PLCB1/ADCY4/SP1/PLCB4/CREB1/CREB5/ITPR1/ATF6B/ADCY6/PLCB3/PDE8A	-0.186200789999214
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1963	149/9376	0.961683767141787	GABRE/GNAI3/GNB4/PRKCA/PLCB1/NDUFB5/ADCY4/NDUFC2/GNG12/MT-ND6/NDUFA5/NDUFB3/PLCB4/NDUFV2/NDUFA8/MAPK8/NDUFB8/NDUFC1/NDUFS4/MAPK1/ITPR1/GNGT2/SLC17A7/NDUFB6/NDUFB4/GNG11/ADCY6/GNG10/GNG5/PLCB3	-0.242602049666899
NA	NA	hsa04519	Cadherin signaling	82/1963	404/9376	0.969459757998215	VAV3/SAV1/NFKBIA/MPDZ/GABRE/STK3/DSP/SCN1B/PCDHGB7/RYK/SHOC2/CYFIP1/PPP1CC/CDC42/TEAD2/MOB1A/FZD6/MYO7A/PTK2/FLT4/YAP1/CTNNB1/ARPC5L/NCKAP1/AFDN/PCDHGA10/KDR/CDH26/WWTR1/PCDH9/PCDHGB5/ERBIN/PCDHGA12/CSNK1A1/CTNND1/ARPC1B/ARPC1A/MYO1B/ADAM10/YWHAG/LATS1/KRAS/IKBKB/CTNNA1/ACTR2/EP300/MYO1D/NFKB1/PPP1CB/PSEN1/YWHAQ/APC/ATN1/MAPK8/AMOTL1/TJP1/PCDH12/TCF7/GJA1/ACTR3/PCDHGB6/CDH22/MAPK1/ANKRD6/LHFPL6/LRP6/FAT4/BRK1/ABI2/PCDHGC3/YWHAZ/GSK3B/FZD9/ACTR3C/PCDHGA8/DVL3/PCDHGA6/DVL1/ARPC3/WASF1/TAOK2/ACTN1	-0.322899455099309
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1963	76/9376	0.942703166474515	CD36/ACSL3/FABP5/HMGCS1/PLIN5/SCP2/PPARG/ACADM/CPT1A/DBI/ACSL4/PPARD/ACSL5/UBC/PLIN4	-0.258074284180532
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1963	51/9376	0.936541707870107	PAFAH1B1/AGPS/CHPT1/PLA2G4C/CEPT1/PLD1/PAFAH1B2/PAFAH1B3/SELENOI/LPCAT4	-0.233828710893599
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1963	86/9376	0.944164721771375	ATF2/PCLO/CAMK2D/PRKCA/GNAS/PLCB1/KCNN3/ADCY4/PLCB4/CREB1/ATP1A1/CREB5/ATF6B/ADCY6/KCNN2/PLCB3/RAPGEF4	-0.267669471321918
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1963	21/9376	0.909783373359532	CSGALNACT1/CHST15/DSEL/CHST12	-0.212972301137248
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/1963	138/9376	0.934505747635607	SDHD/CYCS/NDUFB5/NDUFC2/ATP6V1C1/COX11/MT-ND6/NDUFA5/NDUFB3/ATP6V1D/NDUFV2/ATP5F1C/NDUFA8/ATP6V0A1/NDUFB8/NDUFC1/NDUFS4/UQCRC2/COX7A2L/ATP6V1B2/NDUFB6/ATP6V1G1/UQCRH/NDUFB4/COX10/COX15/ATP6V1C2	-0.398843520568606
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1963	27/9376	0.884511612988434	HMGCS1/HADH/ACAT2/GAD1/ACSM2A	-0.309233407378331
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1963	48/9376	0.89556800815079	PIK3CA/PLCB1/PLCB4/ATP1A1/AKT3/AKT1/PIK3CB/PLCB3/PIK3R3	-0.373257634463693
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	19/1963	99/9376	0.916675671642559	IGF1/CAMK2D/PRKCA/PIK3CA/GNAS/PPP1CC/PLCB1/ADCY4/PLCB4/MAP2K6/PLA2G4C/PPP1CB/MAPK8/ITPR1/PIK3CB/CALM1/ADCY6/PLCB3/PIK3R3	-0.428878651429751
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1963	22/9376	0.868429583661372	ALDH2/ALDH9A1/ALDH3A2/CNDP2	-0.317921350439093
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/1963	79/9376	0.906904312051433	ATP6V1C1/SYT1/NSF/ATP6V1D/CLTC/ATP6V0A1/STX3/SLC17A7/ATP6V1B2/ATP6V1G1/AP2M1/UNC13B/CLTA/STX1B/ATP6V1C2	-0.427583052817064
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	22/1963	115/9376	0.913738953243704	DUSP1/CASP3/GNAI3/GNB4/PRKCA/GNAS/PLCB1/APP/GNG12/BRAF/PLCB4/KRAS/PLA2G4C/MAPK1/ITPR1/GNGT2/TRPC1/GNG11/KCNN2/GNG10/GNG5/PLCB3	-0.478942624725263
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1963	17/9376	0.842887537083096	CYP39A1/HSD17B4/SCP2	-0.333633123759548
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/1963	116/9376	0.905861893301948	SDHD/SUCLA2/IDH1/ACO1/GLUD1/RPE/HIBCH/ESD/PCCA/ACAT2/MDH1/DLST/PSPH/IDH3A/PDHB/SUCLG2/ME2/RPIA/DLD/FH/ALDH6A1/PGP	-0.524973944153554
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1963	65/9376	0.881790038794624	ALDH2/AGPAT5/LPIN2/ALDH9A1/ALDH3A2/GPAT3/MBOAT2/DGKE/DGKH/GLA/GPAM/LIPC	-0.492109079298782
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1963	39/9376	0.857295871050329	BHMT2/MTHFS/MAT2A/MAT2B/DLD/MTHFD2L/TYMS	-0.459530086653763
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1963	23/9376	0.830671775676095	GLS/GLUD1/ARG2/NAGS	-0.418375835740323
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1963	23/9376	0.830671775676095	GLS/GLUD1/ATP1A1/MDH1	-0.418375835740323
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1963	91/9376	0.892287539256464	GABRE/GNAI3/GNB4/PRKCA/PDE1A/GNAS/ADCY4/GNG12/PDE7B/GABBR1/GNGT2/GNG11/ADCY6/GNG10/PDE2A/GNG5/PDE8A	-0.531305703136116
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1963	71/9376	0.874545284954762	GLS/MYC/PIK3CA/PTEN/IDH1/KRAS/AKT3/HIF1A/MAPK1/PDHB/AKT1/PIK3CB/PIK3R3	-0.546017751091758
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1963	45/9376	0.849131148468897	ABCD4/TAP1/ABCG1/ABCC5/ABCA5/ABCA6/TAP2/ABCD3	-0.522024077351009
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1963	18/9376	0.796060451689591	NEU1/MAN2B1/HEXA	-0.445651090063462
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1963	128/9376	0.89556800815079	NTPCR/PNP/NUDT9/PDE1A/NT5C2/ADCY4/PDE6D/PDE7B/GMPR2/DCK/GMPS/NT5E/AK6/ENTPD4/NME7/LACC1/NUDT2/PGM1/RRM2B/ADCY6/PDE2A/ADSL/FHIT/PDE8A	-0.612157850909027
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	18/1963	98/9376	0.877291110025263	ATF2/PRKD3/CAMK2D/PRKCA/GNAS/PLCB1/ADCY4/PLCB4/CREB1/ATP1A1/ATF1/CREB5/ITPR1/ATF6B/CALM1/ADCY6/PDE2A/PLCB3	-0.62836309361303
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1963	46/9376	0.830671775676095	CPOX/ALAS1/HCCS/COX10/HEPH/COX15/EARS2/BLVRA	-0.592401618023781
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/1963	89/9376	0.858671947889896	SV2B/CD36/ITGA2/CD47/SDC4/LAMB1/ITGAV/ITGA1/COL4A1/ITGA9/RELN/ITGA6/COL9A3/COL4A5/LAMC2/ITGA8	-0.689341526775432
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/1963	95/9376	0.854717537603561	FOS/CXCL2/CXCL1/JUN/ATP6V1C1/TGFB3/ATP6V1D/ATP6V0A1/TEK/CXCL8/ICAM1/CXCL3/ATP6V1B2/ATP6V1G1/TNFRSF11A/CSF1/ATP6V1C2	-0.732363002251079
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1963	48/9376	0.796060451689591	PDCD6IP/LAMP2/CLDN5/CHMP7/CHMP4B/TSG101/CHMP1B/OCLN	-0.72891450242422
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1963	37/9376	0.774545304346629	GLS/RIMKLB/GLUD1/ASRGL1/GAD1/ADSL	-0.707064034945722
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1963	37/9376	0.774545304346629	PRKCA/PLCB1/PLCB4/ICAM1/PLCB3/IL12A	-0.707064034945722
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/1963	70/9376	0.818805036023579	CASP3/EIF4G2/SGCE/CYCS/BID/HLA-F/SNTB2/SGCD/ICAM1/EIF4G3/FYN/CD55	-0.783001162488707
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1963	86/9376	0.833086519210037	ITGA2/DSP/SGCE/CTNNB1/ITGAV/ITGA1/ATP2A2/ITGA9/ITGA6/CTNNA1/SNTB2/SGCD/TCF7/GJA1/ITGA8	-0.800168720868767
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	4/1963	26/9376	0.734825032328853	HES1/HHEX/NR5A2/MAFA	-0.696726262280181
Genetic Information Processing	Translation	hsa03010	Ribosome	41/1963	222/9376	0.882121041061438	MRPL18/RPS21/RPL37/RPL26/RPL36A/RPS10/MRPL44/MRPL32/MRPL42/MRPL50/MRPS22/MRPL9/RPL22L1/MRPL19/RSL24D1/MRPS35/RPS13/MRPS18C/MRPL15/MRPL35/MRPS30/MRPL30/RPS23/RPS15A/MRPL11/MRPL47/MRPL22/MRPS10/MRPL13/MRPS28/MRPL45/RPS7/RPL30/MRPL52/MRPL49/RPL14/MRPS31/RPL39/RPL32/MRPS17/MRPL10	-0.914652472682719
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1963	82/9376	0.815476560267386	GSTM3/MGST2/CMPK1/GMPS/TPMT/CDADC1/DUT/NME7/MGST3/DPYD/RRM2B/UCKL1/GSTO1/UMPS	-0.863586653536914
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1963	66/9376	0.796060451689591	IFNGR1/JUN/STAT3/IFNGR2/MAF/STAT1/TGFB3/NFATC1/TLR5/NFKB1/IL12A	-0.855553886127736
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1963	99/9376	0.820183495680184	IGF1/ITGA2/SGCE/ITGAV/TGFB3/ITGA1/ATP2A2/ITGA9/ITGA6/PRKAA1/PRKAA2/SNTB2/SGCD/PRKAG2/TTN/TPM4/ITGA8	-0.92553353141559
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1963	76/9376	0.754162533179612	GNAI3/CAMK2D/PRKCA/GNAS/PLCB1/ADCY4/PLCB4/ATP1A1/ITPR1/CALM1/ADCY6/PLCB3	-1.10729205037497
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1963	36/9376	0.663383709741326	PGM2L1/GYG1/PGM1/GBE1/GANC	-1.04126610039094
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1963	36/9376	0.663383709741326	C1GALT1C1/GALNT18/GALNT7/ST6GALNAC3/GALNT10	-1.04126610039094
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1963	30/9376	0.636848361351673	ABCC5/IKBKB/NFKB1/TYMS	-1.02514319965019
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1963	105/9376	0.773315867355603	IGF1/ITGA2/SGCE/GNAS/ITGAV/ADCY4/TGFB3/ITGA1/ATP2A2/ITGA9/ITGA6/SNTB2/SGCD/TTN/TPM4/ADCY6/ITGA8	-1.20199114577222
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1963	31/9376	0.616304865824199	DERA/RPE/RPIA/PGM1	-1.10109876044332
NA	NA	hsa04981	Folate transport and metabolism	4/1963	31/9376	0.616304865824199	BHMT2/MTHFS/ABCC5/TYMS	-1.10109876044332
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1963	44/9376	0.651322187746029	HSPD1/PTPRN2/HLA-F/ICA1/GAD1/IL12A	-1.19292207015105
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1963	50/9376	0.668690779419256	CD36/HGF/TGFB3/PECAM1/CXCL8/ICAM1/IL12A	-1.20870302033565
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1963	32/9376	0.597045338767193	B4GALT1/PGM1/GLA/GANC	-1.17493420183074
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1963	102/9376	0.749233366296085	PRKCA/RAB8A/GNAS/PLCB1/RAB11A/ADCY4/ATP2A2/PLCB4/RAP1A/ATP1A1/ITPR1/TRPC1/RAP1B/ADCY6/SLC12A2/PLCB3	-1.31034325664581
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1963	19/9376	0.502775022119742	HPSE/HEXA	-1.11637527868443
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1963	26/9376	0.55111877424664	LMBRD1/ABCD4/CUBN	-1.17939993119839
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1963	52/9376	0.642971903287746	IGF1/GNAS/ADCY4/PLA2G4C/HSD17B7/AKR1C3/ADCY6	-1.32846991008173
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1963	93/9376	0.719022343461566	PRKCA/GNAS/PLCB1/ADCY4/PLCB4/ADRB2/ATP1A1/PRKG1/ITPR1/PRH1/CALM1/ADCY6/SLC12A2/PLCB3	-1.40125725119844
NA	NA	hsa04081	Hormone signaling	37/1963	219/9376	0.806965389383969	IGF1/SMAD9/SMAD1/GNAI3/STAT3/GNB4/PIK3CA/GNAS/PLCB1/SMAD4/SMAD5/ITGAV/ADCY4/GNG12/PLCB4/ADRB2/THRA/AVPR2/ADIPOR2/PRKG1/GNA13/ADIPOR1/GNGT2/LEPR/PIK3CB/GNG11/ADCY6/STK11/HEPH/GNG10/GNG5/JAK2/PLCB3/PIK3R3/VIP/RAMP2/RAPGEF4	-1.48740563392245
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	38/1963	226/9376	0.803105234447906	VAV3/FOS/NFKBIA/JUN/GNAI3/CAMK2D/PIK3CA/GNAS/PPP1CC/ADCY4/AFDN/BRAF/NFATC1/ATP2A2/CREB1/RAP1A/ADRB2/EP300/NFKB1/ATP1A1/PPP1CB/CREB5/AKT3/PLD1/GABBR1/MAPK8/ARAP3/MAPK1/PLCE1/GRIN2B/AKT1/PIK3CB/CALM1/RAP1B/ADCY6/PIK3R3/VIP/RAPGEF4	-1.54179499332248
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1963	134/9376	0.748534454573794	CALCRL/MYH10/ARHGEF12/PRKCA/GNAS/PPP1CC/PLCB1/ADCY4/BRAF/PLCB4/PLA2G4C/ARHGEF11/PPP1CB/PRKG1/GNA13/MAPK1/ITPR1/CALM1/ADCY6/PLCB3/RAMP2	-1.50867847323921
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1963	35/9376	0.545870024015719	ENOSF1/GMDS/PFKFB3/KHK	-1.38505268529166
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1963	29/9376	0.494106487255608	SLC24A1/CALM1/RGS9	-1.40401185832331
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1963	37/9376	0.516363536231086	FAHD1/LRTOMT/COMT/PNMT	-1.51676570110158
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1963	75/9376	0.636848361351673	IDH1/ACO1/MAT2A/RPE/MAT2B/ARG2/PSPH/IDH3A/RPIA/NAGS	-1.62481008349142
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1963	23/9376	0.415335887838047	LNPEP/ATP6AP2	-1.44458691118866
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1963	38/9376	0.502775022119742	TAP1/TAP2/DCLRE1C/RAG1	-1.58039842632162
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1963	31/9376	0.46222864936815	ALDH2/ALDH9A1/ALDH3A2	-1.54325482613849
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1963	24/9376	0.398030225844795	HS6ST1/GLCE	-1.51941652320303
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1963	17/9376	0.280962512361032	GLUD1	-1.5268981126474
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1963	61/9376	0.548107196245292	TRPM7/ATP1A1/MT1X/SLC30A1/CLCN2/HEPH/MT2A	-1.82203913670476
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1963	63/9376	0.53070696779306	PTGES3/GGT5/PLA2G4C/LTA4H/AKR1C3/LTC4S/EPHX2	-1.92317306252033
Human Diseases	Substance dependence	hsa05034	Alcoholism	28/1963	191/9376	0.700199769025399	SOS2/ATF2/GNAI3/HAT1/GNB4/SOS1/GNAS/PPP1CC/GNG12/BRAF/FOSB/CREB1/KRAS/PPP1CB/CREB5/CAMKK2/HDAC8/MAPK1/GRIN2B/GNGT2/ATF6B/CALM1/PKIA/GNG11/SHC1/GNG10/GNG5/SHC2	-2.15406028873764
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1963	66/9376	0.506583923802467	HSD17B11/HSD17B12/HSD17B7/SRD5A3/AKR1C3/LRTOMT/COMT	-2.06994692773453
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/1963	194/9376	0.689371937545625	MYH10/DYNLL1/KIF2A/DYNC1I1/MYO7A/DYNLT3/MYO5C/KIF3C/CAPZA2/MYO18A/MYO1B/MYL12A/MYO6/KIF9/MYO1D/MYO9A/ACTR10/MYL12B/DYNC1H1/TUBD1/DYNLT1/DYNC1LI2/STARD9/MYO5A/KIF6/TPM4/DYNC2H1/DYNLRB1	-2.24968491624209
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1963	67/9376	0.499022969715863	ALDH2/ALDH9A1/ALDH3A2/PDHB/DLD/PGM1/MINPP1	-2.11764173778024
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1963	100/9376	0.573163525216505	CXCL2/TNFRSF10D/CXCL1/CCL21/TNFRSF10B/ACKR3/TNFRSF1A/IL6ST/TNFSF10/CXCL8/CXCL3/CSF1	-2.20815696894702
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1963	88/9376	0.542768489788357	CFI/F8/CD46/PROS1/THBD/PROCR/PLAT/TFPI/C1R/CD55	-2.21750788569778
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	34/1963	233/9376	0.696979966286165	CSRP2/ITGA2/TMOD2/MYH10/PDLIM3/TMOD3/DSP/ELN/SDC4/SGCE/FHL1/LBR/ITGAV/CAPZA2/SUN1/SPTAN1/ANK2/ITGA1/COL4A1/ITGA9/ITGA6/TMEM43/ATP1A1/COL9A3/FMNL2/SNTB2/COL4A5/SGCD/FLNC/TTN/SPTBN1/TPM4/DIAPH2/ITGA8	-2.41020359970301
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1963	41/9376	0.349489954400308	ALAS1/PSPH/DLD	-2.14801625115843
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1963	41/9376	0.349489954400308	GABRE/GRIN2B/SLC17A7	-2.14801625115843
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1963	23/9376	0.207667943919024	B4GALT1	-1.95769244891283
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	25/1963	183/9376	0.652508566958681	XPO1/XRN1/BMS1/NMD3/NXT1/RPP30/RIOK2/CSNK2A2/NVL/HEATR1/AK6/GNL3L/NOP10/RAN/UTP6/NOB1/NXF1/RPP38/POP7/UTP18/PWP2/LSG1/XRN2/WDR3/WDR36	-2.44281065051269
Organismal Systems	Sensory system	hsa04742	Taste transduction	9/1963	86/9376	0.499851911526022	SCN9A/PDE1A/PLCB1/ADCY4/PLCB4/SCN3A/GABBR1/ADCY6/PLCB3	-2.39766646950932
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	49/1963	323/9376	0.724587531878451	EFNA5/GLS/CDKN1B/CDC25B/SOS2/CASP3/EFNA1/SIRT1/STAT3/BCL2L11/STMN1/MYC/PRKCA/MCL1/PIK3CA/NOTCH1/PTEN/SOS1/MMP16/ATM/SOCS1/CCNG1/MDM2/KRAS/IKBKB/ZFPM2/CRK/SLC45A3/EP300/RECK/NFKB1/MAPK7/APC/MARCKS/MDM4/MAPK1/UBE2I/FSCN1/SPRY2/EZH2/SOX4/PIK3CB/BMI1/EFNA4/HNRNPK/CDKN1A/SHC1/PIK3R3/FOXP1	-2.59201425778337
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1963	36/9376	0.26535348389653	RPE/CRYL1	-2.27250592180495
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1963	26/9376	0.183706258082213	PLA2G4C	-2.14474726903479
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1963	39/9376	0.244941677442951	HLA-F/IL12A	-2.43140838984172
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1963	30/9376	0.159212090337918	PLA2G4C	-2.3734658368783
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1963	43/9376	0.222156405122676	CD36/ACAT2	-2.63065964522891
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1963	70/9376	0.341168765009825	GSTM3/MGST2/EPHX1/MGST3/GSTO1	-2.84701964977519
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1963	254/9376	0.620551060765901	EDNRB/HGF/CAMK2D/PRKCA/ASPH/ITPKC/PDE1A/GNAS/PLCB1/FLT4/ADCY4/KDR/PPP3R1/NFATC1/ATP2A2/PPP3CC/VDAC3/PPP3CA/PLCB4/SLC25A5/ADRB2/ORAI3/NFATC3/STIM2/TPCN1/ITPR1/PLCE1/GRIN2B/VDAC2/VDAC1/CALM1/STIM1/PLCB3	-3.15481542350603
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1963	87/9376	0.384305045643251	ASPH/ATP2A2/ATP1A1/UQCRC2/COX7A2L/UQCRH/TPM4	-2.9688586938439
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1963	73/9376	0.327148130831339	GSTM3/MGST2/FMO5/MGST3/GSTO1	-2.96973823660685
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1963	90/9376	0.371494877455142	GNAS/EPHX1/ADCY4/ATP1A1/HMGCR/ADCY6/KCNN2	-3.08293611055755
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1963	160/9376	0.507488537952114	CD99/SDC4/NECTIN3/ITGAV/CLDN5/NCAM1/ITGA9/ITGA6/CD274/HLA-F/PECAM1/PTPRM/F11R/ICAM1/OCLN/NEO1/ITGA8	-3.23335871215692
NA	NA	hsa04082	Neuroactive ligand signaling	23/1963	199/9376	0.552041921272179	GABRE/GNAI3/GNB4/PRKCA/GNAS/PLCB1/ADCY4/OGFR/GNG12/PLCB4/ADRB2/GABBR1/GRIN2B/GNGT2/SLC17A7/ACHE/GNG11/ADCY6/GNG10/GNG5/GRIK1/PLCB3/OGFRL1	-3.2867171700461
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1963	68/9376	0.280962512361032	ALDH1A1/DHRS4L2/RDH11/DHRS4	-3.0621509123382
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1963	79/9376	0.302301437350478	GSTM3/MGST2/EPHX1/MGST3/GSTO1	-3.2044887141129
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1963	103/9376	0.370979627971848	ELN/SLC38A2/COL4A1/ATP1A1/COL9A3/COL4A5/COL8A2/SLC36A4	-3.30310197407293
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1963	195/9376	0.514377522630197	HAT1/CASP4/PRKCA/PIK3CA/PLCB1/VDAC3/PLCB4/SLC25A5/NFKB1/CASP1/AKT3/CLCN3/HDAC8/MAP3K7/MAPK1/AKT1/VDAC2/PIK3CB/VDAC1/PLCB3/PIK3R3	-3.52630505797892
NA	NA	hsa04382	Cornified envelope formation	24/1963	217/9376	0.528261313563599	PPP2R5A/DSP/PCSK6/PPP2R3C/SPTLC2/PPP2R5C/CLDN5/COL4A1/SPTLC1/PPP2CB/ITGA6/PPP2R2D/ELOVL1/ABHD5/PPP2CA/S100A10/COL4A5/TJP1/PPP2R1B/LAMC2/OCLN/EPHX2/BLMH/PPP2R5B	-3.61789633560756
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/1963	100/9376	0.334345389709628	CD36/ITGA2/IL7/ITGA1/ITGA6/CD55/CSF1	-3.44363697448762
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1963	45/9376	0.106141393558612	HLA-F	-3.09285654112391
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1963	50/9376	0.0955272542027509	IL15RA	-3.29975404167774
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1963	54/9376	0.0884511612988434	HLA-F	-3.45677458809642
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/1963	298/9376	0.464813820785197	CXCL2/TNFRSF10D/IL7/LIF/TGFBR2/CXCL1/IFNGR1/BMP2/IFNGR2/CCL21/TNFRSF10B/ACKR3/TGFB3/TNFSF12/TNFRSF1A/IFNAR1/IL6ST/TNFSF10/TNFSF9/CXCL8/IL15RA/CXCL3/LEPR/ACVR2B/GDF3/TNFRSF11A/ACVR1B/CSF1/IL12A	-4.83133019713934
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/1963	99/9376	0.144738263943562	CFI/ICAM1/C1R	-4.40211769131646
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1963	143/9376	0.167005689165648	TRIM21/GRIN2B/SSB/C1R/ACTN1	-5.16520335176739
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1963	370/9376	0.219454502898212	CALCRL/GABRE/EDNRB/PGRMC1/LPAR6/OGFR/NR3C1/S1PR1/ADRB2/THRA/AVPR2/GABBR1/GRIN2B/LEPR/GRIK1/OGFRL1/VIP	-7.88282529151986
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1963	449/9376	0.0638266731866932	CAMK2D/PDE1A/NCALD/PRKG1/CALM1/PDE2A	-10.4610542479621