category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	82/2306	142/9376	2.34792274898306	SOCS1/CUL1/MDM2/UBA2/BIRC6/CUL3/UBE2S/SMURF2/UBA6/UBE2Q2/UBE2A/RNF7/TRIP12/UBE2J1/UBE2F/UBE2N/UBE2B/HERC4/HERC2/UBE3A/BIRC2/ANAPC5/UBE2G1/CUL2/UBE2H/ITCH/FBXW7/CUL5/CDC16/UBE2M/FZR1/UBE2D2/UBE2I/ANAPC16/FANCL/UBE2Q1/UBE2L6/DDB2/SKP1/ANAPC7/UBE2E3/ANAPC4/UBE4A/HUWE1/MAP3K1/UBA3/UBE2Z/CDC26/PPIL2/UBE2D3/CDC23/UBE2J2/CBLB/UBE2D1/RCHY1/BIRC3/UBE2W/SIAH1/ANAPC10/UBA7/CDC27/COP1/ANAPC1/SYVN1/HERC3/CUL4B/UBE2O/UBE4B/BTRC/TRAF6/PRPF19/SKP2/PIAS4/UBB/FBXW8/TRIM37/RHOBTB2/BRCA1/ERCC8/SMURF1/FBXO2/RPS27A	9.24314621011838
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	67/2306	108/9376	2.52237319713469	DDX39B/XPO1/KPNA4/KPNA2/SUMO1/RAN/NUP54/MAGOH/EIF4A3/THOC7/PNN/NUP50/NMD3/RNPS1/SUMO2/ACIN1/NUP98/NUP58/TNPO1/SENP2/PHAX/UBE2I/THOC3/IPO7/KPNA1/NUP153/NCBP1/NXT1/NCBP2/TNPO3/THOC1/RANBP2/NUP210/NXF1/XPOT/KPNA3/RBM8A/RAE1/SAP18/NUP88/TMEM33/MAGOHB/SUMO4/NUP133/NUP214/POM121C/IPO11/XPO4/NUP160/NUP205/KPNA5/NUP37/NUP107/GLE1/XPO5/NUP35/IPO9/NUP155/CSE1L/NUP85/IPO13/THOC6/NXT2/NUP43/THOC5/RANBP17/IPO4	9.08752413183429
Human Diseases	Infectious disease: viral	hsa05162	Measles	72/2306	136/9376	2.15254323758992	MX1/OAS2/CCND3/CASP8/OAS1/CASP3/IRF7/EIF2AK2/TBK1/HSPA8/CD3E/CCND2/CYCS/EIF2S1/MSN/HSPA1A/BCL2/CDKN1B/BID/ADAR/NFKB1/STAT1/IL2RB/STAT3/EIF3H/CASP9/CD46/IRAK4/IRF9/JAK3/PIK3CA/OAS3/MX2/BAX/BAK1/CSNK2A1/IL2RA/CSNK2A2/PIK3CD/CBLB/RCHY1/RAB9A/FASLG/MYD88/RELA/CSNK2B/MAPK9/HSPA1B/JAK1/CHUK/TP53/IL2RG/AKT1/GSK3B/MAPK8/IKBKB/APAF1/CDK2/TRAF3/IRAK1/BBC3/TRADD/CDK6/FAS/TYK2/TRAF6/FADD/IKBKG/HSPA6/MAP3K7/TNFAIP3/PIK3R1	7.73207892188959
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	84/2306	174/9376	1.96285551933487	CUL1/HSPH1/HSPA5/HERPUD1/DNAJA2/DDIT3/ERO1A/HSPA8/DNAJB11/CALR/STT3B/UBE2J1/EIF2S1/PDIA3/HSPA1A/BCL2/CAPN2/DNAJC3/PDIA6/RAD23B/HYOU1/DERL2/ERO1B/XBP1/UBE2G1/FBXO6/DNAJC10/UBQLN1/DDOST/SAR1A/DERL1/ERN1/DNAJB12/DAD1/TRAM1/ATF6B/SAR1B/UBE2D2/DNAJA1/OSTC/HSP90AB1/SEC61B/SSR2/SEC24D/UGGT1/MOGS/TMEM258/SKP1/BAX/BAK1/PDIA4/NGLY1/BAG2/MBTPS1/SEC23B/PLAA/UBE2D3/UBE2J2/UFD1/EIF2AK3/UBE2D1/SEC23A/UBQLN2/ATXN3/MAPK9/HSPA1B/EDEM2/EDEM3/MAPK8/PREB/SYVN1/SEC24A/HSP90AA1/SEC24B/RNF5/SEC61A2/UBE4B/MAN1B1/SEC61G/DNAJB1/YOD1/HSPA6/DERL3/FBXO2	7.3215025284192
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	78/2306	158/9376	2.0072238629003	CUL1/CCND3/BUB3/MDM2/GADD45A/RBL2/PPP2R5A/ESCO1/CDKN2C/CDKN2D/CDC14A/CCND2/CCNH/EP300/HDAC1/TFDP1/ATM/CDKN1B/DBF4/ANAPC5/WEE1/WAPL/STAG2/CDC16/FZR1/YWHAZ/PPP2CA/RB1/PDS5B/ANAPC16/SMAD4/CDKN2A/BUB1/SKP1/STAG1/SMC3/ATR/ANAPC7/ANAPC4/MAD2L1BP/MAD2L2/MCM3/ORC4/PRKDC/MCM4/CDC26/TFDP2/CDC23/HDAC8/RAD21/RBL1/PCNA/MAD2L1/ANAPC10/PPP2R1B/ORC2/CDC27/TP53/E2F4/ANAPC1/GSK3B/MCM5/ATRX/MCM6/CDK2/CDK7/CDK6/MAD1L1/SKP2/CCNB1/DDX11/E2F5/YWHAB/PTTG1/CHEK1/MCM2/ORC5/NDC80	7.29191807650505
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	96/2306	214/9376	1.82396187110423	CUL1/BST2/APOBEC3G/B2M/CASP8/CASP3/RAC2/TBK1/GNAI3/KRAS/TAP1/CD3E/CALR/AP1G1/RNF7/CYCS/PPP3CA/MAPK1/PPP3CC/MAP2K3/PDIA3/AP1S3/ATM/BCL2/MAP2K1/ITPR1/BID/NFKB1/HLA-F/WEE1/TRAF5/APOBEC3C/GNG5/MAP2K2/CUL5/PTK2B/SAMHD1/CASP9/IRAK4/RAF1/HLA-B/LIMK1/TRIM5/GNGT2/PIK3CA/SKP1/ATR/BAX/PPP3R1/BAK1/APOBEC3H/PXN/TAP2/HLA-A/APOBEC3D/CALM3/PIK3CD/RPS6KB1/NRAS/CD247/CALM1/NFATC3/FASLG/MYD88/RELA/AP1S1/MAP2K6/RIPK1/MAPK9/RPS6KB2/GNAI2/CHUK/CRKL/AKT1/MAPK8/IKBKB/MTOR/IRAK1/CUL4B/CGAS/TRADD/APOBEC3F/NFATC2/FAS/BTRC/TAB1/TRAF6/CFL1/CCNB1/FADD/GNG10/IKBKG/CHEK1/MAP3K7/APOBEC3B/PIK3R1	6.96344966863076
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	46/2306	78/9376	2.39784731024974	HSPD1/DDX6/HSPA9/XRN1/LSM5/BTG3/C1D/LSM8/DCP2/PNPT1/LSM2/LSM1/MTREX/CNOT7/LSM4/CNOT4/TENT4B/CNOT9/DIS3/CNOT2/EXOSC5/XRN2/TOB2/ZCCHC7/LSM6/PFKP/EXOSC6/EXOSC1/MPHOSPH6/CNOT10/CNOT8/DCPS/EXOSC3/EXOSC9/EXOSC8/PAN3/CNOT6/EXOSC7/NUDT16/EXOSC2/ENO1/TENT4A/PABPC1L/CNOT3/BTG1/EDC4	7.07974879623639
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	83/2306	180/9376	1.87483858533295	OAS2/SRSF5/BST2/B2M/SRSF6/CASP8/ZC3HAV1/OAS1/CASP3/IRF7/EIF2AK2/TBK1/SP100/SRSF2/TAP1/SRSF9/CALR/SYK/SRSF7/CYCS/EIF2S1/PPP1CB/PPP1CC/PDIA3/BCL2/BID/IFNGR1/BIRC2/SRSF1/NFKB1/HLA-F/STAT1/TRAF5/SRSF3/PILRB/SRSF4/SRSF8/CASP9/IRAK4/HLA-B/IRF9/PIK3CA/OAS3/BAX/BAK1/TNFSF14/EIF2B1/NXF1/TAP2/HLA-A/PIK3CD/EIF2B5/BIRC3/FASLG/JAK2/SRPK1/MYD88/RELA/HCFC1/JAK1/CHUK/TP53/AKT1/IKBKB/APAF1/EIF2B3/MTOR/TRAF3/IRAK1/CGAS/TRADD/TSC1/NECTIN1/FAS/TYK2/TAB1/TRAF6/EIF2B2/FADD/IKBKG/HCFC2/MAP3K7/PIK3R1	6.76815480651204
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	105/2306	248/9376	1.72145594941667	CASP8/CASP3/LEF1/ARPC5L/ACTR3/ARF6/IL18/CASP1/PYCARD/KPNA4/DYNLT1/CASP4/DYNLT3/PIK3CG/CYTH4/RHOH/TUBA4A/CYCS/ACTR2/MAPK1/CTNNB1/PTPRC/MAP2K3/EXOC4/BCL2/EXOC5/MAP2K1/BIRC2/CDC42/ARPC1B/NFKB1/SNX18/RAB5A/ACBD3/MAP2K2/FBXO22/ARPC3/MYL12A/ACTR10/IRAK4/ARF1/HSP90AB1/RAF1/KPNA1/M6PR/STX10/CYTH1/PIK3CA/CYFIP2/SKP1/NCKAP1L/TXN2/BAX/BAK1/DYNLL1/MLKL/ABI1/MYL12B/KPNA3/PIK3CD/BRK1/RAB9A/PLEKHM1/BIRC3/MYD88/DNM2/EXOC2/TNFRSF10A/VPS33A/RELA/TCF7/VPS41/VPS11/ELMO2/MAP2K6/RIPK1/MAP2K4/MAPK9/CHUK/CYTH2/AKT1/DCTN6/MAPK8/IKBKB/ARPC5/CASP7/HSP90AA1/IRAK1/TRADD/TUBA1B/TNFRSF10B/ARHGEF26/TAB1/TRAF6/VPS39/ARPC2/RPS3/RHOA/RILP/FADD/IKBKG/CSE1L/MAP3K7/ACTR3C/PIK3C2B	6.57587314455788
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	67/2306	138/9376	1.97403119775758	RAC2/ARPC5L/ACTR3/TBK1/ARF6/IL18/CASP1/PYCARD/ARHGEF12/ARHGEF1/LCP2/ACTR2/MAPK1/MAP2K3/MAP2K1/CDC42/ARPC1B/SKAP2/NFKB1/VAV3/ZAP70/MAP2K2/ARHGEF7/WIPF1/ARPC3/PTK2B/IRAK4/RPS6KA3/PKN2/LIMK1/PIK3CA/WAS/PXN/LAT/VAV1/PIK3CD/ROCK1/RPS6KA1/NFATC3/GIT2/MYD88/RELA/ITGA4/ELMO2/MAP2K6/MAP2K4/MAPK9/CHUK/CRKL/AKT1/GSK3B/MAPK8/IKBKB/ARPC5/IRAK1/PIP5K1A/NFATC2/TAB1/TRAF6/CD8A/ARPC2/RHOA/IKBKG/LCK/MAP3K7/ACTR3C/PIK3R1	6.58307820443384
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	54/2306	103/9376	2.13164475955507	DDX39B/CPSF6/PAPOLA/PPP2R5A/ETF1/WDR33/PPP1CB/MAGOH/PPP1CC/PABPN1/EIF4A3/HBS1L/GSPT1/RNMT/PNN/SMG1/RNPS1/RNGTT/ACIN1/PPP2R2B/FIP1L1/PPP2R2A/PPP2CA/NCBP1/NXT1/MSI2/SSU72/TARDBP/NCBP2/PPP2R3C/NXF1/PELO/NUDT21/SMG7/RBM8A/CSTF1/CSTF3/SAP18/MAGOHB/DAZAP1/PAPOLG/PPP2R1B/CPSF7/CPSF1/GSPT2/CSTF2/PPP2R2D/CLP1/CPSF3/GLE1/PABPC1L/FUS/CPSF4/NXT2	6.59514247211503
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	66/2306	137/9376	1.95876197289204	GZMB/CASP8/GADD45A/CASP3/BCL2L11/PMAIP1/DDIT3/CASP10/KRAS/PARP4/TUBA4A/CYCS/EIF2S1/MAPK1/CTSC/ATM/BCL2/CAPN2/MAP2K1/SPTAN1/ITPR1/BID/BIRC2/NFKB1/CTSW/MCL1/PRF1/MAP2K2/ERN1/CASP9/RAF1/PIK3CA/BAX/BAK1/LMNB1/PIK3CD/NRAS/DFFA/EIF2AK3/BIRC3/FASLG/TNFRSF10A/AIFM1/RELA/HTRA2/RIPK1/CASP2/MAPK9/CHUK/TP53/AKT1/MAPK8/IKBKB/APAF1/CASP7/BBC3/CASP6/TRADD/TUBA1B/FAS/TNFRSF10B/PARP3/FADD/IKBKG/PARP2/PIK3R1	6.45600983342442
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	88/2306	205/9376	1.74536839210543	OAS2/CCND3/B2M/CASP8/PSMD12/MDM2/GADD45A/OAS1/CASP3/IRF7/EIF2AK2/BCL2L11/TBK1/TAP1/CD3E/CALR/SYK/CCND2/CYCS/CD58/HDAC1/MAP2K3/PDIA3/BCL2/CDKN1B/BID/NFKB1/HLA-F/PSMD13/STAT1/TRAF5/SNW1/STAT3/CASP9/PSMD6/PSMC4/RB1/IRAK4/RUNX3/USP7/HLA-B/IRF9/JAK3/PSMC6/PIK3CA/DDB2/OAS3/BAX/BAK1/TAP2/HLA-A/PIK3CD/PSMD11/SAP30/CD247/MYD88/PSMC2/RELA/MAP2K6/RIPK1/MAP2K4/MAPK9/JAK1/CHUK/TP53/AKT1/MAPK8/IKBKB/APAF1/SIN3A/CDK2/TRAF3/IRAK1/TRADD/CDK6/NFKBIE/ISG15/CD44/FAS/TYK2/TAB1/TRAF6/SKP2/FADD/IKBKG/MAP3K7/TNFAIP3/PIK3R1	6.16233265672812
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	59/2306	122/9376	1.96630315783487	MALT1/ITK/PPP2R5A/KRAS/MAP3K8/SOS2/CD3E/LCP2/PPP3CA/MAPK1/PPP3CC/PTPRC/MAP2K1/CDC42/NFKB1/VAV3/ZAP70/MAP2K2/BCL10/PPP2R2B/PPP2R2A/CARD11/PPP2CA/RASGRP1/TEC1/RAF1/PIK3CA/PTPN6/SOS1/PPP3R1/GRB2/PPP2R3C/LAT/VAV1/PIK3CD/NRAS/CBLB/CD247/NCK1/NFATC3/RELA/MAPK9/PPP2R1B/CHUK/AKT1/GSK3B/MAPK8/IKBKB/PPP2R2D/NFATC2/NFKBIE/FYN/CD8A/RHOA/IKBKG/NCK2/LCK/MAP3K7/PIK3R1	6.13527663241647
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	71/2306	157/9376	1.83872589368084	CCND3/MDM2/GADD45A/RRAS2/RBL2/PPID/HIPK1/RBBP4/KRAS/CCND2/PPP3CA/RASSF5/PPP1CB/PPP1CC/VDAC3/MAPK1/VDAC2/PPP3CC/MAP2K3/HIPK3/ATM/CAPN2/MAP2K1/ITPR1/NFKB1/HLA-F/SIRT1/MAP2K2/VDAC1/TRPM7/ZFP36L2/RB1/RAF1/HLA-B/CDKN2A/PTEN/PIK3CA/ATR/PPP3R1/SLC25A5/HLA-A/CALM3/PIK3CD/NRAS/KIR2DL4/CALM1/NFATC3/RELA/RBL1/MAP2K6/TP53/HUS1/E2F4/LIN54/AKT1/MRE11/RAD1/CDK2/MTOR/RAD9A/TSC1/NFATC2/CDK6/MRAS/BTRC/CCNB1/ETS1/E2F5/CHEK1/PIK3R1/LIN9	6.05248264118867
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	75/2306	169/9376	1.80440014985348	PRKACB/RRAS2/CALCOCO2/TBK1/BIRC6/HIF1A/KRAS/SH3GLB1/DDIT4/MAP1LC3B/EIF2S1/RAB8A/MAPK1/BCL2/MAP2K1/ITPR1/DAPK2/NRBF2/STX17/SUPT20H/ATG12/GORASP2/MAP2K2/ERN1/IGBP1/ATG5/ATG16L1/PPP2CA/GABARAPL2/RAF1/PTEN/VMP1/TANK/NBR1/PIK3CA/VAMP8/OPTN/HMGB1/PIK3CD/WDR41/ATG3/ATG4A/RPS6KB1/NRAS/EIF2AK3/PLEKHM1/TAX1BP1/VPS33A/VPS41/VPS11/MTMR14/MAPK9/RPS6KB2/EPG5/AKT1/MAPK8/MTOR/MTMR4/ATG2B/TSC1/STK11/MRAS/ATG4D/TRAF6/VPS39/PRKCD/UBB/RRAGB/RAB33B/PIK3R4/MAP3K7/RAB39B/ATG4C/PIK3R1/RPS27A	6.02645622588338
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	138/2306	368/9376	1.52471812662619	PSMD12/PSMA2/HSPA5/CASP3/COX6A2/NDUFC2/TBK1/DDIT3/CASP1/CHCHD10/ATP5F1C/HNRNPA2B1/SRSF7/PSMA5/UQCRC2/MAP1LC3B/TUBA4A/NDUFB3/CYCS/EIF2S1/NUP54/PPP3CA/RAB8A/PPP3CC/NDUFB5/MAP2K3/BCL2/SETX/BID/UQCRFS1/NRBF2/XBP1/NUP50/ATXN2L/PSMD13/HNRNPA3/SDHA/RAB5A/PSMA6/NDUFV2/NUP98/COX5A/SRSF3/SPG11/ATP5MC3/NDUFA13/SDHD/PSMA1/UBQLN1/NDUFAB1/NDUFB8/NDUFA9/DERL1/VDAC1/ERN1/PSMB2/NUP58/NDUFS4/HNRNPA1/ACTR10/CASP9/PSMD6/PSMC4/NDUFA10/SDHB/NDUFA2/NDUFA12/NDUFA6/NUP153/TANK/NCBP1/NXT1/PSMC6/TARDBP/COX7A2L/ATP5MC1/BAX/PPP3R1/NDUFB9/NDUFB6/RANBP2/PSMA3/NUP210/NXF1/PSMB3/ATP5F1A/OPTN/CAT/NDUFA8/COX7B/RAE1/UQCR10/NDUFB4/WDR41/NDUFS3/PSMD11/COX7C/NUP88/COX7A2/EIF2AK3/UQCRH/CYC1/PSMC2/PSMD9/UBQLN2/NUP133/MAP2K6/NUP214/SOD1/TP53/COX6A1/CCS/DCTN6/POM121C/APAF1/NDUFA7/NUP160/MTOR/NUP205/PSMB1/ATG2B/NUP37/NUP107/TUBA1B/GLE1/NUP35/ATP5MC2/NDUFA4/FUS/NUP155/TOMM40/NUP85/PIK3R4/RAB39B/NXT2/NUP43/DNAL4/HDAC6	5.86464016947423
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	47/2306	90/9376	2.12331116893129	HIF1A/KRAS/CD3E/PPP3CA/MAPK1/PPP3CC/MAP2K3/MAP2K1/IFNGR1/NFKB1/STAT1/ZAP70/MAP2K2/STAT3/RASGRP1/RAF1/PTEN/PIK3CA/PTPN6/PPP3R1/CSNK2A1/LAT/CSNK2A2/PIK3CD/RPS6KB1/NRAS/CD247/NFATC3/JAK2/MYD88/RELA/CSNK2B/EML4/MAP2K6/RPS6KB2/JAK1/CHUK/AKT1/IKBKB/MTOR/NFATC2/NFKBIE/BATF/TRAF6/IKBKG/LCK/PIK3R1	6.11522688724623
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	45/2306	87/9376	2.10305948500165	GADD45A/CASP3/LEF1/RAC2/BCL2L11/PMAIP1/KRAS/SOS2/CYCS/MAPK1/CTNNB1/BCL2/MAP2K1/MAP2K2/MSH6/CASP9/RAF1/SMAD4/PIK3CA/DDB2/SOS1/BAX/MSH3/GRB2/BAK1/APPL1/BRAF/MSH2/AREG/PIK3CD/RPS6KB1/NRAS/TCF7/MAPK9/RPS6KB2/TP53/AKT1/GSK3B/MAPK8/MTOR/MLH1/BBC3/RHOA/ARAF/PIK3R1	5.90309348520858
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	61/2306	133/9376	1.86481815988366	KLRC1/KLRC2/GZMB/CASP3/KLRD1/RAC2/FCER1G/SH2D1B/KRAS/SOS2/SYK/KLRC3/LCP2/PPP3CA/MAPK1/PPP3CC/LAT2/MAP2K1/BID/IFNGR1/VAV3/PRF1/ZAP70/MAP2K2/NCR3/NCR1/KIR2DL3/PTK2B/RAF1/HLA-B/PIK3CA/PTPN6/SOS1/PPP3R1/GRB2/HLA-A/BRAF/LAT/VAV1/PIK3CD/NRAS/CD48/CD247/KIR2DL4/FASLG/TNFRSF10A/HCST/MICB/TYROBP/NFATC2/FAS/TNFRSF10B/FYN/NCR2/KLRK1/LCK/ARAF/KIR2DL1/CD244/ULBP2/PIK3R1	5.73653605213835
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	92/2306	227/9376	1.64785982554608	PRKACB/B2M/CASP8/MDM2/PTGER2/CASP3/RAC2/CCR1/TBK1/GNAI3/KRAS/IL10RA/TAP1/SOS2/CALR/ARHGEF12/ARHGEF1/CYCS/PPP3CA/MAPK1/CTNNB1/PPP3CC/PDIA3/PTGER3/MAP2K1/ITPR1/BID/NFKB1/HLA-F/GNA13/TRAF5/GNG5/MAP2K2/STAT3/ATF6B/PTK2B/CASP9/ATF2/RB1/RAF1/HLA-B/CDKN2A/ADCY7/GNGT2/PIK3CA/SOS1/BAX/PPP3R1/GRB2/BAK1/PXN/TAP2/HLA-A/CALM3/PIK3CD/ROCK1/RPS6KB1/NRAS/CALM1/NFATC3/FASLG/RELA/MAP2K6/RIPK1/RPS6KB2/GNAI2/JAK1/CHUK/CRKL/TP53/PLCB2/AKT1/GSK3B/ADCY3/IKBKB/MTOR/CGAS/TRADD/PTGER1/TSC1/NFATC2/CDK6/ELK1/FAS/PLCB1/RHOA/FADD/GNG10/IKBKG/PLCB3/ADCY6/PIK3R1	5.64303504410145
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	91/2306	224/9376	1.65177797051171	CCND3/PRKACB/B2M/BUB3/XPO1/KRAS/CD3E/CALR/CDKN2C/CCND2/EP300/RAN/PPP3CA/VDAC3/MAPK1/VDAC2/PPP3CC/ELK4/ATM/MAP2K1/ANAPC5/NFKB1/HLA-F/TBPL1/IL2RB/MAP2K2/RANBP1/CDC16/VDAC1/ATF6B/ATF2/RB1/ANAPC16/SMAD4/HLA-B/CDKN2A/ADCY7/PTEN/JAK3/PIK3CA/ATR/ANAPC7/BAX/ANAPC4/GPS2/PPP3R1/MAP3K1/SLC25A5/POLB/IL2RA/HLA-A/TRRAP/CDC26/PIK3CD/NRAS/CDC23/NFATC3/RELA/MAD2L1/ANAPC10/CRTC3/MAP2K4/ZFP36/MAPK9/JAK1/CHUK/CDC27/TP53/KAT2B/ANAPC1/IL2RG/AKT1/MAPK8/ADCY3/IKBKB/TBP/CDK2/NFATC2/MAD1L1/ELK1/KAT2A/KAT5/ETS1/IKBKG/PTTG1/CHEK1/NFYB/ADCY6/LCK/TCF3/PIK3R1	5.63859969937238
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	71/2306	163/9376	1.77104273195026	CASP8/CASP3/IRF7/TBK1/CASP10/KRAS/SOS2/EP300/CYCS/VDAC3/MAPK1/MAP2K3/BCL2/MAP2K1/STAT4/BID/NFKB1/STAT1/MAP2K2/STAT3/ATF6B/PTK2B/YWHAZ/CASP9/ATF2/RB1/IRAK4/RAF1/SMAD4/JAK3/PIK3CA/DDB2/SOS1/BAX/MAP3K1/GRB2/DDX3X/BRAF/PIK3CD/NRAS/NFATC3/FASLG/JAK2/MYD88/RELA/PCNA/MAP2K6/MAP2K4/MAPK9/JAK1/CHUK/TP53/AKT1/MAPK8/IKBKB/APAF1/CDK2/TRAF3/IRAK1/NFATC2/ELK1/FAS/TYK2/TAB1/TRAF6/YWHAB/FADD/IKBKG/MAP3K7/ARAF/PIK3R1	5.67123047588616
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	42/2306	83/9376	2.0574509660498	OGT/RBBP4/JARID2/MTF2/CBX4/EP300/HDAC1/SUZ12/TFDP1/AEBP2/PCGF5/LCOR/EZH2/RBBP7/UBE2D2/PHC3/MBD5/USP7/YY1/KDM2A/RNF2/ASXL2/SKP1/PHF1/EED/UBE2D3/UBE2D1/ASXL1/CSNK2B/FBRS/HCFC1/MGA/FOXK2/PCGF6/FOXK1/BCOR/L3MBTL2/CBX8/USP45/BAP1/TEX10/KDM2B	5.52620381959566
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	86/2306	216/9376	1.61883652950435	CASP8/HSPA5/CASP3/IRF7/HSPD1/TBK1/DDIT3/ERO1A/IL18/HSPA4/CASP1/CAMK2D/KRAS/HSPA8/PYCARD/ARHGEF1/CYCS/RAP1A/EIF2S1/PPP3CA/MAPK1/PPP3CC/MAP2K3/HSPA1A/BCL2/ITPR1/BID/CDC42/XBP1/NFKB1/VAV3/STAT3/ERN1/CASP9/IRAK4/HSP90AB1/TANK/PIK3CA/BAX/PPP3R1/ABCG1/VAV1/CALM3/PIK3CD/NRAS/EIF2AK3/CALM1/CAMK2G/NFATC3/FASLG/JAK2/MYD88/TNFRSF10A/RELA/RXRA/MAP2K6/MAP2K4/MAPK9/HSPA1B/CHUK/TP53/PLCB2/AKT1/GSK3B/MAPK8/IKBKB/APAF1/CASP7/HSP90AA1/TRAF3/IRAK1/NCF4/CASP6/NFATC2/FAS/TNFRSF10B/TAB1/TRAF6/PLCB1/RHOA/IKBKG/HSPA6/PLCB3/MAP3K7/PIK3R1/CYP2J2	5.25485411195022
Genetic Information Processing	Transcription	hsa03040	Spliceosome	94/2306	243/9376	1.57282308809725	SRSF5/SRSF6/DDX39B/TRA2A/BCAS2/DDX5/PRPF8/SRSF2/HSPA8/SRSF9/WBP11/CDC40/SRSF7/CWC15/SNRPF/LSM5/BUD31/PHF5A/MAGOH/SF3B6/SF3B1/SRSF10/EIF4A3/SMNDC1/LSM8/PRPF38A/SNRPB2/LSM2/SNRNP27/HSPA1A/THOC7/CRNKL1/SRSF1/HNRNPA3/SNW1/PPIE/ACIN1/ZMAT2/SRSF3/HNRNPK/U2SURP/SRSF4/HNRNPU/PRPF18/SF3B5/LSM4/SRSF8/CCDC12/HNRNPA1/SNRNP40/RBM22/SNRNP70/THOC3/SF3B4/SF3B3/NCBP1/SNRPD3/CDC5L/PPIH/AQR/SNRPD1/RBM17/LSM6/SYF2/SNRPC/NCBP2/PRPF3/PRPF31/CWC25/THOC1/TRA2B/SNRPB/USP39/HNRNPC/PLRG1/DDX23/RBM8A/SNRPE/SNRPA1/CHERP/PRPF40A/U2AF1L4/RBMXL1/PPIL1/MAGOHB/SNRPA/HSPA1B/BUD13/PRPF19/YJU2/FUS/HSPA6/THOC6/THOC5	5.16681016115016
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	23/2306	36/9376	2.59766791943722	PRIM1/RNASEH2B/RPA2/SSBP1/RPA1/MCM3/MCM4/FEN1/PCNA/PRIM2/RNASEH1/RFC2/POLA1/MCM5/MCM6/RPA3/RFC4/POLA2/DNA2/POLE2/MCM2/POLD4/POLD1	5.4849151033449
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	66/2306	156/9376	1.72019480952699	MX1/OAS2/CASP8/OAS1/CASP3/IRF7/EIF2AK2/TBK1/RSAD2/KRAS/SOS2/CYCS/EIF2S1/MAPK1/CTNNB1/MAP2K1/BID/NFKB1/STAT1/MAP2K2/STAT3/PPP2R2B/PPP2R2A/YWHAZ/PPP2CA/CASP9/RB1/RAF1/IRF9/PIK3CA/OAS3/SOS1/MX2/BAX/GRB2/BAK1/EIF3E/BRAF/PIK3CD/NRAS/FASLG/RELA/RXRA/RIPK1/IFIT1/JAK1/PPP2R1B/CHUK/TP53/AKT1/GSK3B/IKBKB/APAF1/CDK2/PPP2R2D/TRAF3/TRADD/CDK6/FAS/TYK2/TRAF6/YWHAB/FADD/IKBKG/ARAF/PIK3R1	5.18027014759175
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	71/2306	173/9376	1.6686703196988	MX1/OAS2/CCND3/CASP8/OAS1/CASP3/IRF7/EIF2AK2/CALCOCO2/TBK1/RSAD2/XPO1/IL18/CASP1/PYCARD/TRIM25/KPNA2/EP300/CYCS/EIF2S1/PABPN1/MAPK1/DNAJC3/MAP2K1/BID/IFNGR1/ADAR/NFKB1/STAT1/NUP98/MAP2K2/VDAC1/CASP9/IRAK4/RAF1/KPNA1/IRF9/NXT1/PIK3CA/OAS3/HNRNPUL1/MX2/BAX/SLC25A5/BAK1/NXF1/RAE1/PIK3CD/FASLG/JAK2/MYD88/TNFRSF10A/RELA/JAK1/CHUK/AKT1/IKBKB/APAF1/TRAF3/KPNA5/TRADD/CDK6/FAS/TYK2/TNFRSF10B/DNAJB1/FADD/IKBKG/CPSF4/NXT2/PIK3R1	5.06962656581908
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	96/2306	253/9376	1.54279778820674	CUL1/MDM2/MALT1/PPID/ARPC5L/ACTR3/CALCOCO2/TBK1/ARF6/IL18/CASP1/RBCK1/PYCARD/CASP4/CYTH4/MAP1LC3B/CYCS/ACTR2/MAPK1/UBE2N/ATM/BCL2/CAPN2/ITPR1/CDC42/ARPC1B/NFKB1/ATG12/TRAF5/HCLS1/BCL10/FNBP1L/VDAC1/ATG5/ATG16L1/ARPC3/MYL12A/UBE2D2/ARF1/UBE2V2/TIFA/CYTH1/PIK3CA/SKP1/BAX/UBE2V1/DIAPH1/GLMN/PXN/MYL12B/PIK3CD/ROCK1/RPS6KB1/UBE2D3/U2AF1L4/RPS6KA5/ACTN4/UBE2D1/MYD88/RELA/ELMO2/RIPK1/MAPK9/RPS6KB2/CHUK/CRKL/TP53/PLCB2/CYTH2/AKT1/GSK3B/MAPK8/IKBKB/MTOR/ARPC5/CGAS/TRADD/CD44/BTRC/TAB1/TRAF6/PLCB1/PRKCD/ARPC2/UBB/RHOA/RRAGB/IKBKG/PLCB3/PIK3R4/MAP3K7/CAST/WASF1/ACTR3C/PIK3R1/RPS27A	4.99844681294281
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	95/2306	250/9376	1.54504770164788	MDM2/ARFGAP3/STAM/ARPC5L/ACTR3/ARF6/SMAP2/ARAP2/VPS26A/HSPA8/SMURF2/PSD4/SH3GLB1/RAB11FIP4/CHMP5/CAPZA1/EPS15/CYTH4/SNX1/ACTR2/RAB8A/PDCD6IP/CAPZA2/SNX3/HSPA1A/VPS36/CDC42/ARPC1B/HLA-F/ARF4/AGAP2/IL2RB/RAB5A/ARFGEF1/ITCH/IST1/IGF2R/WIPF1/SMAP1/ARPC3/SNX5/EPS15L1/RAB10/ACAP2/ARRB2/RAB22A/SNX4/ARF1/HLA-B/RAB11FIP1/ARF5/GRK2/VPS29/ACAP1/CYTH1/STAMBP/VTA1/SNX6/IL2RA/HLA-A/ARFGAP2/RUFY1/CBLB/CHMP4A/ZFYVE27/GIT2/DNM2/ARFGEF2/BIN1/RAB4A/WASHC2A/HSPA1B/WASHC1/CYTH2/STAM2/IL2RG/ARAP1/VPS45/ARPC5/RUFY2/GIT1/PIP5K1A/WASHC5/CHMP7/WASHC2C/TRAF6/LDLRAP1/ARPC2/RNF41/RHOA/RAB11FIP2/HSPA6/SMURF1/ACTR3C/PARD6B	4.98849874796079
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	33/2306	63/9376	2.12976500227151	MNAT1/POLR2K/POLR2B/CCNH/GTF2H2/RAD23B/XPA/RPA2/POLR2H/POLR2C/POLR2F/POLR2J/DDB2/RPA1/POLR2D/ERCC5/PCNA/GTF2H3/RFC2/GTF2H5/RPA3/CUL4B/POLR2M/CDK7/ERCC3/GTF2H1/GTF2H2C/RFC4/ERCC4/POLE2/ERCC8/POLD4/POLD1	5.13829664144237
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	21/2306	33/9376	2.58740045730505	STX17/SEC22B/VTI1A/STX8/VAMP1/STX4/SNAP23/VAMP2/VAMP8/GOSR2/STX3/VAMP7/GOSR1/STX2/BET1/VAMP4/STX5/STX6/BET1L/STX18/BNIP1	5.216820326713
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	65/2306	157/9376	1.68334060689091	CASP8/CASP3/BCL2L11/COX6A2/NDUFC2/DDIT3/UQCRC2/NDUFB3/CYCS/EIF2S1/NDUFB5/BID/UQCRFS1/CDC42/XBP1/NFKB1/SDHA/NDUFV2/COX5A/ITCH/NDUFA13/SDHD/NDUFAB1/NDUFB8/NDUFA9/ERN1/NDUFS4/NDUFA10/SDHB/NDUFA2/NDUFA12/NDUFA6/PIK3CA/MLX/COX7A2L/BAX/NDUFB9/NDUFB6/NDUFA8/COX7B/UQCR10/NDUFB4/PIK3CD/NDUFS3/COX7C/COX7A2/EIF2AK3/UQCRH/FASLG/PRKAG1/CYC1/RELA/RXRA/MAPK9/COX6A1/AKT1/GSK3B/MAPK8/IKBKB/NDUFA7/CASP7/SREBF1/FAS/NDUFA4/PIK3R1	4.93117857978092
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	80/2306	205/9376	1.58669853827766	GTF2B/CCND3/PRKACB/CASP8/MDM2/RASA2/CASP3/IRF7/EIF2AK2/RBL2/PMAIP1/SP100/KRAS/SYK/CCND2/EP300/VDAC3/MAPK1/GTF2H2/HDAC1/CDKN1B/UBE3A/CDC42/NFKB1/HLA-F/TBPL1/GTF2A2/TRAF5/SNW1/HNRNPK/RANBP1/STAT3/ATF6B/YWHAZ/ATF2/RB1/USP7/HLA-B/CDKN2A/IRF9/JAK3/PIK3CA/HDAC3/BAX/GRB2/BAK1/POLB/PXN/DDX3X/HLA-A/PIK3CD/NRAS/ACTN4/HDAC8/GTF2A1/RELA/RBL1/GTF2H3/DNAJA3/JAK1/TP53/KAT2B/TBP/CDK2/TRAF3/TRADD/HDAC5/GTF2H1/CDK6/MAD1L1/HDAC10/GTF2H2C/KAT2A/SKP2/RHOA/YWHAB/IKBKG/CHEK1/HDAC6/PIK3R1	4.85052975196687
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	37/2306	75/9376	2.00585140213935	CCND3/CASP8/MDM2/GADD45A/CASP3/PMAIP1/SESN1/CCND2/CYCS/SESN2/ATM/BCL2/BID/CCNG1/CASP9/CDKN2A/PTEN/DDB2/MDM4/ATR/BAX/RCHY1/CCNG2/TNFRSF10A/SIAH1/PPM1D/COP1/TP53/APAF1/CDK2/RRM2B/BBC3/CDK6/FAS/TNFRSF10B/CCNB1/CHEK1	4.99465181124025
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	38/2306	78/9376	1.98083038672805	SACM1L/PIP4K2A/IP6K2/INPP4A/PIK3CG/PPIP5K2/INPP5D/PTEN/PIKFYVE/PIK3CA/IMPA1/IP6K1/PIK3CD/MTM1/INPP5A/PLCH2/PIP4K2C/MTMR6/ALDH6A1/INPP1/MTMR14/INPP5B/PLCB2/MTMR1/MTMR4/INPP5F/PIP5K1A/MTMR2/PLCB1/SYNJ1/PLCB3/ISYNA1/PIP4K2B/MINPP1/PI4K2B/IPPK/PPIP5K1/PIK3C2B	4.96766184606338
Genetic Information Processing	Translation	hsa03010	Ribosome	85/2306	222/9376	1.55676925841713	RPS10/RPL36A/RPS21/RPL26/RPL37/RPS19/RPL22L1/RPS15A/RPL41/RSL24D1/MRPL42/MRPS30/MRPS31/RPL17/MRPL44/MRPL19/MRPL9/MRPL3/MRPS26/MRPL52/MRPS18C/MRPL34/MRPL18/MRPL47/MRPS12/MRPL11/MRPS15/MRPS35/MRPL51/RPL14/MRPL22/MRPL16/MRPL43/MRPS23/RPL39/MRPL39/MRPS10/MRPL2/DAP3/MRPS25/MRPS22/MRPS34/MRPL14/MRPS14/MRPL13/MRPL1/RPL30/RPL3/MRPL36/MRPL15/MRPL21/MRPL49/MRPS11/MRPS27/RPS23/RPS29/MRPL45/MRPL50/FAU/RPS7/MRPL46/RPS18/RPL32/MRPL30/RPL34/RPS27L/MRPL35/RPL27/RPS25/MRPL48/RPS24/MRPS28/RPL7A/RPL35A/RPLP1/RPS3/RPL23A/RPS4X/RPL35/RPL24/RPS27/RPL36AL/MRPL38/RPL15/RPS27A	4.79459429169295
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	161/2306	480/9376	1.36377565770454	CASP8/PSMD12/PSMA2/HSPA5/CASP3/PPID/COX6A2/NDUFC2/TBK1/DDIT3/CAMK2D/KRAS/ATP5F1C/CSNK1A1/ATP2A2/PSMA5/UQCRC2/MAP1LC3B/TUBA4A/NDUFB3/CYCS/UBE2J1/EIF2S1/PPP3CA/RAB8A/VDAC3/MAPK1/CTNNB1/VDAC2/PPP3CC/NDUFB5/MAP2K3/BCL2/CAPN2/MAP2K1/ITPR1/BID/UQCRFS1/NRBF2/XBP1/UBE2G1/IFT57/NFKB1/ATXN2L/PSMD13/SDHA/RAB5A/PSMA6/NDUFV2/COX5A/SPG11/ATP5MC3/MAP2K2/NDUFA13/SDHD/PSMA1/NDUFAB1/NDUFB8/NDUFA9/DERL1/VDAC1/ERN1/PSMB2/NDUFS4/HTT/ACTR10/CASP9/PSMD6/PSMC4/NDUFA10/CSF1/SDHB/NDUFA2/NDUFA12/RAF1/NDUFA6/TANK/PSMC6/UBE2L6/TARDBP/COX7A2L/ATP5MC1/BAX/PPP3R1/SLC25A5/BAK1/NDUFB9/NDUFB6/PSMA3/CSNK2A1/PSMB3/ATP5F1A/BRAF/OPTN/CAT/CSNK2A2/NDUFA8/COX7B/UQCR10/NDUFB4/CALM3/WDR41/NDUFS3/PSMD11/HSD17B10/COX7C/NRAS/COX7A2/UBE2J2/EIF2AK3/CALM1/UQCRH/CAMK2G/ATXN1L/FASLG/CYC1/PSMC2/RELA/PSMD9/CSNK2B/MAP2K6/HTRA2/UBA7/ATXN3/MAPK9/SOD1/FRAT2/PLCB2/COX6A1/CCS/DCTN6/GSK3B/MAPK8/PARK7/APAF1/NDUFA7/MFN1/MTOR/CASP7/PSMB1/ATG2B/TUBA1B/FAS/ATP5MC2/NDUFA4/CDK5/PLCB1/UBB/PSEN2/FUS/FADD/TOMM40/PLCB3/PIK3R4/RAB39B/ARAF/DNAL4/MAP3K10/RPS27A/FRAT1/WNT11	4.67264136118466
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	36/2306	73/9376	2.00510876926184	MX1/BST2/MDFIC/APOBEC3G/CPSF6/XPO1/EP300/RAN/PDCD6IP/ELL2/PSIP1/APOBEC3C/ELL/SMARCB1/SAMHD1/CCNT2/NUP153/TRIM5/CDK9/CCNT1/MX2/NELFCD/APOBEC3H/TNPO3/RANBP2/APOBEC3D/MLLT3/CHMP4A/NELFB/KAT2B/NELFA/CPSF7/APOBEC3F/KAT2A/PPIA/APOBEC3B	4.92343903340924
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	25/2306	44/9376	2.31017897973666	GTF2B/MNAT1/CCNH/GTF2H2/TAF15/TBPL1/GTF2A2/GTF2I/TAF7/GTF2F1/TAF9/TAF12/GTF2F2/TAF13/GTF2A1/GTF2H3/GTF2H5/TBP/CDK7/ERCC3/GTF2H1/TAF4B/GTF2H2C/TAF5L/TAF4	4.97479493373244
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	34/2306	68/9376	2.03295750216826	PIM1/PIM2/LEF1/KRAS/SOS2/MAPK1/MAP2K1/NFKB1/MAP2K2/STAT3/ITGAM/PER2/RAF1/PIK3CA/SOS1/GRB2/DUSP6/BRAF/PIK3CD/RPS6KB1/NRAS/RELA/TCF7/RPS6KB2/CHUK/AKT1/IKBKB/MTOR/RARA/IKBKG/PPARD/ARAF/KIT/PIK3R1	4.88218583140343
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	20/2306	32/9376	2.54119687771032	CASP8/CASP3/BCL2L11/BIRC6/PMAIP1/CYCS/BCL2/BID/BIRC2/CASP9/BAX/BAK1/BIRC3/HTRA2/MAPK9/MAPK8/APAF1/CASP7/BBC3/FADD	4.9873779121026
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	76/2306	196/9376	1.57657928739579	CASP8/CASP3/IRF7/LEF1/EIF2AK2/PIK3R6/CCR1/TBK1/HIF1A/KRAS/CLEC2B/SYK/PIK3CG/EP300/MAP1LC3B/CYCS/PPP3CA/MAPK1/CTNNB1/PPP3CC/MAP2K1/ITPR1/BID/IFNGR1/NFKB1/HLA-F/STAT1/GNG5/MAP2K2/STAT3/CASP9/RB1/RAF1/HLA-B/IRF9/GNGT2/PIK3CA/BAX/PPP3R1/BAK1/HLA-A/CALM3/PIK3CD/ATG3/NRAS/CALM1/NFATC3/JAK2/RELA/TCF7/MAP2K6/MAP2K4/ZFP36/MAPK9/JAK1/CHUK/TP53/MICB/AKT1/GSK3B/MAPK8/IKBKB/MTOR/TRAF3/PREX1/TRADD/NFATC2/CDK6/FAS/TYK2/UBB/FADD/GNG10/IKBKG/PIK3R1/RPS27A	4.65877047990311
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	37/2306	77/9376	1.95375136572014	ARHGEF6/GADD45A/RAC2/KRAS/MAPK1/MAP2K1/CDC42/NFKB1/STAT1/STAT3/CASP9/RB1/RAF1/SMAD4/CDKN2A/PIK3CA/DDB2/BAX/BAK1/BRAF/PIK3CD/RPS6KB1/RELA/MAPK9/RPS6KB2/JAK1/CHUK/TP53/AKT1/MAPK8/IKBKB/MTOR/CDK6/BRCA2/IKBKG/ARAF/PIK3R1	4.79919055654055
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	100/2306	275/9376	1.47851454703146	STIP1/PRKACB/PSMD12/PSMA2/HSPA5/CASP3/RAC2/COX6A2/NDUFC2/NCAM1/DDIT3/HSPA8/ATP5F1C/PSMA5/UQCRC2/TUBA4A/NDUFB3/CYCS/EIF2S1/PPP3CA/VDAC3/MAPK1/VDAC2/PPP3CC/NDUFB5/HSPA1A/ITPR1/UQCRFS1/PSMD13/SDHA/PSMA6/NDUFV2/COX5A/ATP5MC3/NDUFA13/SDHD/PSMA1/NDUFAB1/NDUFB8/NDUFA9/VDAC1/PSMB2/NDUFS4/ATF6B/CASP9/PSMD6/PSMC4/ATF2/NDUFA10/SDHB/NDUFA2/NDUFA12/NDUFA6/PSMC6/PIK3CA/COX7A2L/ATP5MC1/BAX/PPP3R1/SLC25A5/NDUFB9/NDUFB6/PSMA3/CSNK2A1/PSMB3/ATP5F1A/CSNK2A2/NDUFA8/COX7B/UQCR10/NDUFB4/PIK3CD/NDUFS3/PSMD11/COX7C/COX7A2/EIF2AK3/UQCRH/CYC1/PSMC2/PSMD9/CSNK2B/MAPK9/SOD1/HSPA1B/COX6A1/GSK3B/MAPK8/APAF1/NDUFA7/PSMB1/NCF4/NOTCH1/TUBA1B/FYN/ATP5MC2/NDUFA4/PRKCD/HSPA6/PIK3R1	4.59962597175686
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	26/2306	48/9376	2.20237062734894	HMGCS1/HIBCH/ACAA2/HADH/OXCT1/ALDH3A2/ECHS1/ACADM/HADHB/PCCA/DLD/IVD/AACS/HSD17B10/BCKDHB/ACAD8/ALDH6A1/ACAT2/AUH/DBT/ACADSB/BCAT2/MCCC1/ACADS/HIBADH/PCCB	4.76947186360976
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	97/2306	268/9376	1.47161849037553	PRKACB/PSMD12/PSMA2/HSPA5/CASP3/COX6A2/NDUFC2/GNAI3/DDIT3/CAMK2D/ATP5F1C/PSMA5/UQCRC2/TUBA4A/NDUFB3/CYCS/UBE2J1/EIF2S1/VDAC3/VDAC2/NDUFB5/ITPR1/UQCRFS1/XBP1/UBE2G1/PSMD13/SLC39A10/SDHA/PSMA6/NDUFV2/COX5A/ATP5MC3/NDUFA13/SDHD/PSMA1/NDUFAB1/NDUFB8/NDUFA9/VDAC1/ERN1/PSMB2/NDUFS4/CASP9/PSMD6/PSMC4/NDUFA10/SDHB/NDUFA2/NDUFA12/NDUFA6/PSMC6/UBE2L6/COX7A2L/ATP5MC1/TXN2/BAX/SLC25A5/NDUFB9/NDUFB6/PSMA3/PSMB3/ATP5F1A/NDUFA8/COX7B/UQCR10/NDUFB4/CALM3/NDUFS3/PSMD11/COX7C/COX7A2/UBE2J2/EIF2AK3/CALM1/UQCRH/CAMK2G/CYC1/PSMC2/PSMD9/HTRA2/UBA7/MAPK9/SOD1/GNAI2/TP53/COX6A1/MAPK8/PARK7/APAF1/NDUFA7/MFN1/PSMB1/TUBA1B/ATP5MC2/NDUFA4/UBB/RPS27A	4.47354996797857
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	28/2306	54/9376	2.10825222447078	WDR48/RPA2/FANCL/ATR/POLH/RPA1/USP1/BLM/PMS2/SLX4/REV1/TELO2/MLH1/RAD51C/RPA3/MUS81/BRCA2/FANCG/ERCC4/FANCA/UBE2T/PALB2/BRCA1/RMI2/FANCI/TOP3A/FANCF/ATRIP	4.66430052980834
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	24/2306	44/9376	2.21777182054719	PARP4/MBD4/MPG/TDG/POLB/HMGB1/PARG/POLG/TDP1/OGG1/APEX1/FEN1/PCNA/RFC2/POLG2/APTX/NTHL1/RFC4/POLE2/PARP3/PARP2/MUTYH/POLD4/POLD1	4.62392175191055
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	43/2306	98/9376	1.78402393047418	SACM1L/PIP4K2A/IP6K2/INPP4A/DGKZ/ITPR1/PPIP5K2/INPP5D/PTEN/PIKFYVE/DGKD/PIK3CA/IMPA1/DGKE/IP6K1/CALM3/PIK3CD/MTM1/CALM1/INPP5A/DGKH/PIP4K2C/MTMR6/INPP1/MTMR14/INPP5B/PLCB2/CDS2/MTMR1/MTMR4/INPP5F/PIP5K1A/MTMR2/PLCB1/SYNJ1/PLCB3/PIP4K2B/PIP4P1/PI4K2B/IPPK/PPIP5K1/PIK3C2B/PIK3R1	4.45574937892447
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	35/2306	75/9376	1.89742700202371	CASP8/MDM2/CASP3/PMAIP1/TOP2B/CYCS/MAPK1/ATM/BCL2/BID/BIRC2/XPA/GSTM2/MSH6/CASP9/CDKN2A/PIK3CA/ATP7A/BAX/MSH3/BAK1/POLH/MSH2/PIK3CD/BIRC3/FASLG/TP53/AKT1/APAF1/MLH1/BBC3/FAS/FADD/BRCA1/PIK3R1	4.45626003163104
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	85/2306	235/9376	1.4706501079515	DPF3/PRKACB/COX6A2/NDUFC2/SMARCE1/KRAS/SOS2/ATP5F1C/UQCRC2/NDUFB3/SMARCA2/NDUFB5/MAP2K3/UQCRFS1/COX11/SDHA/COX14/NDUFV2/COX5A/ATP5MC3/NDUFA13/SDHD/COA5/NDUFAB1/NDUFB8/NDUFA9/SMARCB1/KDM3A/NDUFS4/ATF2/NDUFAF7/NDUFA10/SDHB/RPS6KA3/NDUFA2/NDUFA12/NDUFA6/ADCY7/NDUFAF4/SMARCC2/KDM1A/COX7A2L/ATP5MC1/SOS1/GRB2/NDUFB9/NDUFB6/NDUFAF8/ATP5F1A/COA4/NDUFA8/COX7B/UQCR10/NDUFB4/NDUFS3/RPS6KB1/COX7C/NRAS/COX7A2/RPS6KA1/NDUFAF6/UQCRH/ACSL3/PRKAG1/ACTL6A/CYC1/COX19/COA1/ATP5MF/RPS6KB2/COX6A1/COX10/ADCY3/NDUFA7/MTOR/TSC1/ATP5MG/ATP5MC2/NDUFA4/NDUFAF5/CPT1A/SLC25A20/ADCY6/COX15/COX18	4.17292733368892
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	51/2306	125/9376	1.6588933217693	SPTSSB/RAC2/FCER1G/GNAI3/PPP2R5A/KRAS/DEGS1/ORMDL1/ORMDL3/MAPK1/BCL2/MAP2K1/BID/NFKB1/GNA13/MAP2K2/PPP2R2B/PPP2R2A/PPP2CA/RAF1/PTEN/SPTLC1/PIK3CA/BAX/CERS2/PPP2R3C/SGMS1/S1PR4/PIK3CD/SGMS2/ROCK1/CERS5/NRAS/NSMAF/RELA/MAPK9/GNAI2/PPP2R1B/TP53/PLCB2/AKT1/MAPK8/PPP2R2D/TRADD/ABCC1/FYN/SPHK2/PLCB1/RHOA/PLCB3/PIK3R1	4.2352724633072
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	15/2306	23/9376	2.65168369848033	RPA2/MSH6/SSBP1/MSH3/RPA1/MSH2/PMS2/PCNA/RFC2/MLH1/RPA3/RFC4/MLH3/POLD4/POLD1	4.52919392468911
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	74/2306	200/9376	1.50438855160451	CASP8/CASP3/ARPC5L/ACTR3/ARF6/MYO1E/IL18/CASP1/PYCARD/CASP4/ARHGEF12/CYTH4/ARHGEF1/TUBA4A/CYCS/ACTR2/MAPK1/CDC42/ARPC1B/NFKB1/GNA13/HCLS1/WIPF1/ARPC3/CASP9/IRAK4/ARF1/SEC24D/CYTH1/PTPN6/CYFIP2/NCKAP1L/BAX/BAK1/ABI1/TMED10/ROCK1/BRK1/NCK1/FASLG/MYD88/TNFRSF10A/RELA/RIPK1/MAPK9/CHUK/CYTH2/NCL/MAPK8/IKBKB/EZR/ARPC5/SEC24A/CASP7/IRAK1/SEC24B/TRADD/TUBA1B/FAS/MYO1D/TNFRSF10B/LPAR2/TAB1/TRAF6/FYN/ARPC2/RPS3/RHOA/FADD/IKBKG/NCK2/MAP3K7/WASF1/ACTR3C	4.11774168368286
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	106/2306	308/9376	1.39930841058335	CASP8/PSMD12/PSMA2/CASP3/COX6A2/NDUFC2/POLR2K/POLR2B/ATP5F1C/PSMA5/UQCRC2/EP300/TUBA4A/NDUFB3/CYCS/TFAM/VDAC3/VDAC2/NDUFB5/HDAC1/ITPR1/UQCRFS1/NRBF2/IFT57/PSMD13/TBPL1/SDHA/PSMA6/NDUFV2/COX5A/ATP5MC3/NDUFA13/SDHD/PSMA1/NDUFAB1/NDUFB8/NDUFA9/VDAC1/ERN1/PSMB2/NDUFS4/HTT/POLR2H/ACTR10/CASP9/PSMD6/PSMC4/NDUFA10/POLR2C/SDHB/NDUFA2/NDUFA12/NDUFA6/POLR2F/PSMC6/POLR2J/COX7A2L/ATP5MC1/BAX/SLC25A5/NDUFB9/NDUFB6/PSMA3/REST/PSMB3/ATP5F1A/NDUFA8/COX7B/UQCR10/NDUFB4/NDUFS3/PSMD11/COX7C/COX7A2/UQCRH/POLR2D/CYC1/PSMC2/PSMD9/RCOR1/MAPK9/SOD1/TP53/PLCB2/COX6A1/DCTN6/MAPK8/APAF1/TBP/SIN3A/NDUFA7/MTOR/PSMB1/BBC3/ATG2B/TAF4B/TUBA1B/ATP5MC2/NDUFA4/PLCB1/PLCB3/PIK3R4/DNAL4/TAF4/MAP3K10/NRF1	4.06943056865934
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	70/2306	187/9376	1.52200026900297	OAS2/CASP8/OAS1/IRF7/PSTPIP1/TBK1/IL18/CASP1/RBCK1/PYCARD/CARD16/CASP4/SUGT1/MAP1LC3B/VDAC3/MAPK1/VDAC2/BCL2/ITPR1/DNM1L/BIRC2/NFKB1/ATG12/STAT1/IFI16/TRAF5/VDAC1/ATG5/ATG16L1/TRPM7/IRAK4/GABARAPL2/HSP90AB1/PKN2/IRF9/TANK/OAS3/TXN2/CARD8/TP53BP1/TRPV2/GBP4/TXNIP/BIRC3/MYD88/RELA/RIPK1/MAPK9/JAK1/CHUK/PLCB2/GBP3/MAPK8/IKBKB/MFN1/NOD2/HSP90AA1/TRAF3/TYK2/TAB1/TRAF6/PLCB1/PRKCD/RHOA/FADD/IKBKG/PLCB3/MAP3K7/NLRP1/TNFAIP3	4.11777855099806
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	129/2306	388/9376	1.35181194731807	CASP8/PSMD12/PSMA2/CASP3/EIF2AK2/PPID/COX6A2/NDUFC2/DDIT3/KRAS/ATP5F1C/CSNK1A1/ATP2A2/PSMA5/UQCRC2/TUBA4A/NDUFB3/CYCS/EIF2S1/PPP3CA/VDAC3/MAPK1/CTNNB1/VDAC2/PPP3CC/NDUFB5/CAPN2/MAP2K1/ITPR1/BID/UQCRFS1/NRBF2/XBP1/NFKB1/PSMD13/SLC39A10/SDHA/PSMA6/NDUFV2/COX5A/ATP5MC3/MAP2K2/NDUFA13/SDHD/PSMA1/NDUFAB1/NDUFB8/NDUFA9/VDAC1/ERN1/PSMB2/NDUFS4/NAE1/ADAM10/CASP9/PSMD6/PSMC4/NDUFA10/CSF1/SDHB/NDUFA2/NDUFA12/RAF1/NDUFA6/PSMC6/PIK3CA/COX7A2L/ATP5MC1/PPP3R1/SLC25A5/NDUFB9/NDUFB6/PSMA3/CSNK2A1/PSMB3/ATP5F1A/BRAF/CSNK2A2/NDUFA8/COX7B/UQCR10/NDUFB4/CALM3/PIK3CD/NDUFS3/PSMD11/HSD17B10/COX7C/NRAS/COX7A2/EIF2AK3/CALM1/UQCRH/CYC1/PSMC2/RELA/PSMD9/CSNK2B/MAPK9/FRAT2/CHUK/PLCB2/COX6A1/AKT1/GSK3B/MAPK8/IKBKB/APAF1/NDUFA7/MTOR/CASP7/PSMB1/ATG2B/TUBA1B/FAS/ATP5MC2/NDUFA4/CDK5/PLCB1/PSEN2/FADD/IKBKG/PLCB3/PIK3R4/IDE/ARAF/PIK3R1/FRAT1/WNT11	4.04203898063388
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	49/2306	120/9376	1.66024862677074	CAMK2D/KRAS/SOS2/RAP1A/MAPK1/BCL2/MAP2K1/CDC42/NFKB1/MAP2K2/IRAK4/RPS6KA3/RAF1/KIDINS220/SORT1/PIK3CA/SOS1/BAX/MAP3K1/GRB2/MATK/BRAF/CALM3/PIK3CD/GAB1/RPS6KA5/NRAS/CAMK4/RPS6KA1/CALM1/CAMK2G/FASLG/RELA/MAPK9/ARHGDIB/CRKL/TP53/AKT1/GSK3B/MAPK8/IKBKB/IRAK1/NFKBIE/TRAF6/PRKCD/RHOA/PSEN2/SH2B1/PIK3R1	4.15711500666964
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	48/2306	117/9376	1.66806769408677	DPF3/SMARCE1/RBBP4/PHF6/EPC1/SMARCA2/HDAC1/MEAF6/SS18/BRD7/PHF10/PBRM1/ARID2/SMARCB1/RBBP7/ACTR6/BAZ1B/GATAD2A/UCHL5/SMARCA5/DPF2/CHD3/GATAD2B/SMARCC2/YY1/MBD2/BCL7C/BCL7B/YEATS4/TRRAP/MRGBP/EPC2/RUVBL1/ING3/MTA2/INO80D/ACTL6A/CDK2AP2/VPS72/ACTR8/MCRS1/ACTR5/MTA1/BICRAL/KAT5/SS18L1/INO80B/DMAP1	4.15276105068043
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	44/2306	105/9376	1.70381200181721	RRAS2/CALCOCO2/TBK1/HIF1A/KRAS/OPA1/SMURF2/USP15/MAP1LC3B/EIF2S1/ARIH1/RAB5A/GABARAPL2/SAMM50/NBR1/HUWE1/CSNK2A1/OPTN/MTX2/CSNK2A2/NRAS/EIF2AK3/BCL2L13/TOMM70/PGAM5/CCZ1B/TAX1BP1/RELA/CSNK2B/TOMM7/SIAH1/CCZ1/MAPK9/TP53/MAPK8/RHOT1/MFN1/MTX3/MRAS/FUNDC1/UBB/TOMM40/SMURF1/RPS27A	4.14184278645942
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/2306	59/9376	1.92958678171902	GADD45A/LEF1/KRAS/SOS2/MAPK1/CTNNB1/MAP2K1/MAP2K2/CASP9/RAF1/PTEN/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/PIK3CD/NRAS/TCF7/TP53/AKT1/GSK3B/MLH1/ELK1/ARAF/PIK3R1	4.09056671798069
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	18/2306	32/9376	2.28707718993929	HIBCH/SUCLA2/SUCLG2/LDHB/ECHDC1/ECHS1/SUCLG1/PCCA/DLD/BCKDHB/ALDH6A1/DBT/ACACA/MLYCD/ACADS/ACOX3/PCCB/LDHA	4.1650359153406
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	39/2306	93/9376	1.7050611308508	CD3E/MAML3/PPP3CA/MAPK1/PPP3CC/STAT4/IFNGR1/GATA3/NFKB1/STAT1/JAG1/IL2RB/ZAP70/RUNX3/JAK3/PPP3R1/NOTCH2/IL2RA/LAT/JAG2/TBX21/CD247/NFATC3/JAK2/RELA/IL4R/MAPK9/JAK1/CHUK/IL2RG/MAPK8/IKBKB/DLL1/NOTCH1/NFATC2/NFKBIE/TYK2/IKBKG/LCK	3.9023808793924
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	17/2306	30/9376	2.30401850245736	SUCLA2/SUCLG2/SDHA/IDH2/MDH1/PDHA1/SDHD/SUCLG1/SDHB/DLST/IDH3A/DLD/PDHB/FH/DLAT/ACLY/CS	4.08542343089591
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	53/2306	138/9376	1.56154706688286	COX6A2/NDUFC2/ATP5F1C/UQCRC2/NDUFB3/CYCS/NDUFB5/UQCRFS1/COX11/SDHA/NDUFV2/COX5A/ATP5MC3/NDUFA13/SDHD/NDUFAB1/NDUFB8/NDUFA9/TCIRG1/ATP6V1G1/NDUFS4/NDUFA10/ATP6V1D/SDHB/NDUFA2/NDUFA12/NDUFA6/ATP6V1H/COX7A2L/ATP5MC1/ATP6V0E2/NDUFB9/NDUFB6/ATP5F1A/NDUFA8/COX7B/UQCR10/NDUFB4/NDUFS3/PPA1/COX7C/COX7A2/UQCRH/CYC1/ATP5MF/COX6A1/COX10/NDUFA7/PPA2/ATP5MG/ATP5MC2/NDUFA4/COX15	3.79526678947338
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	38/2306	91/9376	1.69785461719547	RAC2/MALT1/PIK3AP1/KRAS/SOS2/SYK/PPP3CA/MAPK1/PPP3CC/MAP2K1/NFKB1/VAV3/INPP5D/MAP2K2/BCL10/CARD11/RAF1/PIK3CA/PTPN6/SOS1/PPP3R1/GRB2/VAV1/PIK3CD/NRAS/NFATC3/DAPP1/RELA/BANK1/CHUK/AKT1/GSK3B/IKBKB/NFATC2/NFKBIE/IKBKG/PIK3R1/LILRA2	3.82032474207333
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	32/2306	73/9376	1.78231890601053	GADD45A/KRAS/SOS2/RASSF1/RASSF5/MAPK1/MAP2K1/MAP2K2/STAT3/CASP9/RB1/RAF1/CDKN2A/JAK3/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/PIK3CD/NRAS/RXRA/EML4/TP53/AKT1/STK4/CDK6/FHIT/ARAF/PIK3R1	3.83212201128735
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	26/2306	56/9376	1.88774625201338	CASP8/CASP3/HSPD1/IL18/CASP1/HSPA8/PYCARD/CYCS/HBS1L/HSPA1A/NFKB1/SEC22B/CLK4/SAR1A/ITGAM/SAR1B/CASP9/ARF1/HSF1/BCL2L13/MYD88/RELA/HSPA1B/APAF1/CASP7/HSPA6	3.80522628071974
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	79/2306	227/9376	1.41501006758848	PRKD3/COX6A2/NDUFC2/HIF1A/KRAS/SOS2/ATP5F1C/UQCRC2/NDUFB3/VDAC3/MAPK1/VDAC2/NDUFB5/ACP1/MAP2K1/UQCRFS1/NFKB1/SDHA/NDUFV2/COX5A/GSTM2/ATP5MC3/MAP2K2/NDUFA13/SDHD/NDUFAB1/NDUFB8/NDUFA9/PTPRJ/VDAC1/NDUFS4/NDUFA10/SDHB/NDUFA2/NDUFA12/RAF1/NDUFA6/PTEN/PIK3CA/COX7A2L/ATP5MC1/SOS1/GRB2/SLC25A5/NDUFB9/NDUFB6/ATP5F1A/BRAF/CAT/NDUFA8/COX7B/UQCR10/NDUFB4/PIK3CD/NDUFS3/COX7C/NRAS/COX7A2/UQCRH/CYC1/RELA/ARNT/MAP2K4/MAPK9/SOD1/CHUK/COX6A1/AKT1/MAPK8/IKBKB/NDUFA7/ATP5MC2/NDUFA4/PRKCD/IKBKG/SLC26A6/ARAF/PIK3R1/SLC26A2	3.61485040854742
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	33/2306	77/9376	1.74253500185851	MDM2/GADD45A/KRAS/SOS2/MAPK1/HDAC1/MAP2K1/CDKN1B/NFKB1/MAP2K2/RB1/RAF1/SMAD4/CDKN2A/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/PIK3CD/NRAS/RELA/CHUK/CRKL/TP53/AKT1/IKBKB/CDK6/IKBKG/ARAF/PIK3R1	3.73636892894978
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	42/2306	105/9376	1.62636600173461	CASP8/MDM2/RRAS2/MALT1/FCER1G/CYLD/CASP1/KRAS/PYCARD/SYK/ARHGEF12/PPP3CA/MAPK1/PPP3CC/ITPR1/NFKB1/STAT1/BCL10/RAF1/IRF9/PIK3CA/PPP3R1/IRF1/CALM3/PIK3CD/NRAS/CBLB/CALM1/NFATC3/RELA/MAPK9/KSR1/CHUK/AKT1/MAPK8/IKBKB/NFATC2/MRAS/PRKCD/RHOA/IKBKG/PIK3R1	3.68608307228284
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	18/2306	34/9376	2.15254323758992	POLR2K/POLR2B/CRCP/POLR3GL/POLR1D/POLR3K/POLR2H/POLR2C/POLR2F/POLR2J/POLR1E/POLR3E/POLR2D/POLR3C/POLR2M/POLR3A/POLR3F/POLR3G	3.84487598821479
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	40/2306	99/9376	1.64279394114607	PRKACB/MDM2/KRAS/SOS2/CDKN2C/MAPK1/BCL2/MAP2K1/CDKN1B/JAG1/MAP2K2/RB1/RAF1/CDKN2A/ADCY7/PIK3CA/SOS1/BAX/GRB2/NOTCH2/NCOA3/BRAF/NCOR1/PIK3CD/JAG2/RPS6KB1/NRAS/MAPK9/RPS6KB2/TP53/AKT1/MAPK8/ADCY3/MTOR/DLL1/NOTCH1/ADCY6/ARAF/BIK/PIK3R1	3.67190279972299
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	38/2306	93/9376	1.66134161467513	LEF1/RAC2/SMURF2/EP300/RAP1A/MAPK1/CTNNB1/ACP1/CDC42/YES1/FER/PTPRJ/PDCD10/MYL12A/SMAD4/PTPN6/WAS/CSNK2A1/MYL12B/CSNK2A2/ROCK1/ACTN4/TCF7/CSNK2B/SSX2IP/IQGAP1/CCM2/NECTIN3/LMO7/HEG1/NECTIN1/SNAI1/FYN/RHOA/MAP3K7/FARP2/SMURF1/WASF1	3.66040157218777
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	72/2306	205/9376	1.4280286844499	RAC2/COX6A2/NDUFC2/MPC2/CAMK2D/ATP5F1C/ATP2A2/UQCRC2/NDUFB3/PPP1CB/PPP1CC/VDAC3/VDAC2/NDUFB5/UQCRFS1/NFKB1/SDHA/GSR/NDUFV2/COX5A/PDHA1/ATP5MC3/NDUFA13/SDHD/NDUFAB1/NDUFB8/NDUFA9/VDAC1/NDUFS4/NDUFA10/SDHB/NDUFA2/NDUFA12/NDUFA6/PTEN/PIK3CA/COX7A2L/ATP5MC1/SLC25A5/NDUFB9/NDUFB6/ATP5F1A/NDUFA8/COX7B/UQCR10/NDUFB4/PIK3CD/PDHB/NDUFS3/COX7C/COX7A2/UQCRH/CAMK2G/MPC1/CYC1/RELA/MAPK9/PLCB2/COX6A1/AKT1/GSK3B/MAPK8/NDUFA7/MTOR/NCF4/ATP5MC2/NDUFA4/PLCB1/PRKCD/PLCB3/PDK3/PIK3R1	3.53872684720563
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	31/2306	72/9376	1.75060229353378	CASP8/IRF7/TBK1/CYLD/CASP10/RNF125/TRIM25/SIKE1/AZI2/ADAR/NFKB1/ATG12/ATG5/TANK/MAP3K1/DDX3X/OTUD5/RELA/RIPK1/MAPK9/CHUK/MAPK8/IKBKB/TRAF3/TRADD/ISG15/TRAF6/FADD/IKBKG/TKFC/MAP3K7	3.65129453599964
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	46/2306	119/9376	1.57169823697042	CASP8/CASP3/CYLD/CASP10/MAP3K8/MAPK1/MAP2K3/MAP2K1/DNM1L/BIRC2/NFKB1/JAG1/TRAF5/ITCH/ATF6B/ATF2/CSF1/PIK3CA/IRF1/MLKL/BAG4/PIK3CD/RPS6KA5/BIRC3/PGAM5/RELA/FRMD8/MAP2K6/RIPK1/MAP2K4/MAPK9/CHUK/AKT1/MAPK8/IKBKB/NOD2/CASP7/TRAF3/TRADD/FAS/TAB1/FADD/IKBKG/MAP3K7/TNFAIP3/PIK3R1	3.58435308706621
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	35/2306	85/9376	1.67420029590327	HPRT1/NT5C3A/GMPS/NTPCR/DCK/NME3/CTPS1/DGUOK/NT5C2/CMPK2/UPP1/NME7/ENTPD4/PNP/DCTPP1/NME1/AK2/ADSL/NT5C/DTYMK/DCTD/APRT/AMPD2/NUDT16/AMPD3/RRM2B/AK6/IMPDH1/ADK/AK9/NME6/AK4/TYMS/ASMTL/UCK1	3.56592951366134
Human Diseases	Cancer: specific types	hsa05214	Glioma	32/2306	76/9376	1.71196421235222	MDM2/GADD45A/CAMK2D/KRAS/CAMK1/SOS2/MAPK1/MAP2K1/MAP2K2/RB1/RAF1/CDKN2A/PTEN/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/CALM3/PIK3CD/NRAS/CAMK4/CALM1/CAMK2G/TP53/AKT1/MTOR/CDK6/ARAF/PIK3R1	3.55900885497834
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	20/2306	41/9376	1.98337317284708	ATM/UIMC1/RPA2/SSBP1/BARD1/RPA1/TOPBP1/BLM/MRE11/RAD51C/RPA3/RAD51B/RAD51D/MUS81/BRCA2/PALB2/BRCA1/TOP3A/POLD4/POLD1	3.60378361379227
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	34/2306	83/9376	1.66555554394508	CASP8/CASP3/IRF7/TBK1/IL18/CASP1/ZBP1/POLR2K/PYCARD/ADAR/NFKB1/IFI16/G3BP1/POLR3GL/POLR1D/POLR3K/POLR2H/SAMHD1/POLR2F/MLKL/POLR3E/RELA/RIPK1/CHUK/IKBKB/CASP7/POLR3C/CGAS/POLR3A/ZCCHC3/FADD/IKBKG/POLR3F/POLR3G	3.47817128849182
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	51/2306	138/9376	1.50262076247219	SOCS1/PRKACB/PPP1R3B/MKNK2/KRAS/PRKAR1A/SOS2/EIF4E/SOCS4/PPP1CB/PPP1CC/MAPK1/MAP2K1/FLOT1/MAP2K2/PRKAR2B/MKNK1/SOCS2/EIF4E2/RAF1/PIK3CA/SOS1/PHKG2/GRB2/BRAF/CALM3/PIK3CD/RPS6KB1/NRAS/CBLB/CALM1/INPP5A/PRKAG1/MAPK9/RPS6KB2/CRKL/AKT1/GSK3B/MAPK8/IKBKB/MTOR/SREBF1/TSC1/PPP1R3E/ELK1/ACACA/PYGM/PRKAR1B/ARAF/PPP1R3F/PIK3R1	3.3970080159076
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	26/2306	59/9376	1.79175915445338	NT5C3A/DCK/NME3/CTPS1/NT5C2/CMPK2/UPP1/NME7/ENTPD4/NUDT2/DCTPP1/CDADC1/NME1/UMPS/DPYD/NT5C/DTYMK/DCTD/RRM2B/AK9/NME6/TYMS/ASMTL/UCK1/DHODH/CAD	3.48406809300185
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	42/2306	110/9376	1.55244027438303	PRKACB/GNAI3/KRAS/MAPK1/MAP2K1/ANAPC5/CDC16/FZR1/HSP90AB1/RPS6KA3/ANAPC16/RAF1/BUB1/ADCY7/PIK3CA/ANAPC7/ANAPC4/STK10/MAD2L2/BRAF/CDC26/PIK3CD/CDC23/RPS6KA1/MAD2L1/ANAPC10/MAPK9/GNAI2/CDC27/ANAPC1/AKT1/MAPK8/ADCY3/CDK2/HSP90AA1/CPEB2/MAD1L1/CCNB1/SPDYA/ADCY6/ARAF/PIK3R1	3.32844289055315
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2306	98/9376	1.57657928739579	RAC2/ARPC5L/ACTR3/ARF6/SYK/ACTR2/MAPK1/PTPRC/MAP2K1/VASP/CDC42/ARPC1B/VAV3/INPP5D/ARPC3/RAF1/LIMK1/PIK3CA/WAS/LAT/VAV1/PIK3CD/RPS6KB1/DNM2/BIN1/RPS6KB2/CRKL/AKT1/ARPC5/PLA2G6/PIP5K1A/CFL1/SPHK2/PRKCD/ARPC2/WASF1/ACTR3C/PIK3R1	3.27680406408093
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	41/2306	109/9376	1.5293808731908	HIF1A/CD3E/PPP3CA/MAPK1/PPP3CC/IFNGR1/GATA3/NFKB1/STAT1/IL2RB/ZAP70/STAT3/HSP90AB1/SMAD4/IL27RA/JAK3/PPP3R1/IRF4/IL2RA/LAT/TBX21/CD247/NFATC3/JAK2/RELA/RXRA/IL4R/MAPK9/JAK1/CHUK/IL2RG/MAPK8/IKBKB/MTOR/HSP90AA1/NFATC2/NFKBIE/RARA/TYK2/IKBKG/LCK	3.17480822087928
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	29/2306	71/9376	1.66072584684167	SOCS1/KRAS/SOS2/CCND2/SOCS4/MAPK1/MAP2K1/NFKB1/STAT1/CISH/MAP2K2/STAT3/SOCS2/RAF1/PIK3CA/SOS1/GRB2/IRF1/PIK3CD/NRAS/JAK2/RELA/MAPK9/AKT1/GSK3B/MAPK8/TNFSF11/SOCS7/PIK3R1	3.19152216292379
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	55/2306	158/9376	1.41535015973739	KRAS/SOS2/EIF4E/CAB39/DDIT4/MAPK1/RICTOR/SESN2/MAP2K1/FNIP1/SLC3A2/LPIN1/SLC7A5/MAP2K2/ATP6V1G1/LAMTOR3/ATP6V1D/RPS6KA3/EIF4E2/RAF1/PTEN/ATP6V1H/PIK3CA/SOS1/GRB2/BRAF/PIK3CD/EIF4B/RPS6KB1/NPRL2/WDR59/NRAS/RPS6KA1/RPS6KB2/CHUK/AKT1/TELO2/GSK3B/STRADB/IKBKB/TTI1/MTOR/TSC1/STK11/TBC1D7/SKP2/RHOA/FLCN/RRAGB/MIOS/STRADA/PRR5/CASTOR1/PIK3R1/WNT11	3.00697734577814
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/2306	69/9376	1.64993652349888	RAC2/FCER1G/KRAS/SOS2/SYK/LCP2/MAPK1/MAP2K3/MAP2K1/VAV3/INPP5D/MAP2K2/RAF1/PIK3CA/SOS1/GRB2/LAT/VAV1/PIK3CD/ALOX5AP/NRAS/MAP2K6/MAP2K4/MAPK9/AKT1/MAPK8/FYN/PIK3R1	3.09454080861739
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	49/2306	138/9376	1.44369445806152	CUL1/PRKACB/PPP2R5A/CAMK2D/PPP3CA/PPP1CB/PPP1CC/MAPK1/PPP3CC/MAP2K1/ITPR1/ANAPC5/CDC16/YWHAZ/PPP2CA/RPS6KA3/ANAPC16/BUB1/ADCY7/SKP1/SMC3/ANAPC7/ANAPC4/PPP3R1/SLK/MAD2L2/CALM3/CDC26/CDC23/RPS6KA1/CALM1/CAMK2G/MAD2L1/STAG3/ANAPC10/PPP2R1B/CDC27/ANAPC1/ADCY3/REC8/CDK2/CPEB2/MAD1L1/BTRC/CCNB1/YWHAB/SPDYA/PTTG1/ADCY6	2.99874924234182
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	44/2306	122/9376	1.46639557533448	PRKACB/MDM2/HIF1A/KRAS/MED13/ATP2A2/EP300/MED4/MAPK1/CTNNB1/HDAC1/MAP2K1/STAT1/MAP2K2/MED30/ATP1A1/CASP9/RAF1/ATP1B1/PIK3CA/HDAC3/NOTCH2/NCOA3/PFKP/NCOR1/MED14/PIK3CD/NRAS/NCOA1/MED17/RXRA/MED27/TP53/KAT2B/PLCB2/AKT1/GSK3B/SIN3A/MTOR/NOTCH1/KAT2A/PLCB1/PLCB3/PIK3R1	2.96125067129405
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	27/2306	67/9376	1.63850306144904	PRKACB/CAMK2D/KRAS/EP300/RAP1A/PPP3CA/PPP1CB/PPP1CC/MAPK1/PPP3CC/MAP2K1/ITPR1/MAP2K2/RPS6KA3/RAF1/PPP3R1/BRAF/CALM3/NRAS/CAMK4/RPS6KA1/CALM1/CAMK2G/PLCB2/PLCB1/PLCB3/ARAF	2.99539743048818
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	35/2306	93/9376	1.53018306614815	GADD45A/CASP3/CKS2/CYCS/BCL2/CDKN1B/BIRC2/NFKB1/TRAF5/CASP9/RB1/PTEN/PIK3CA/DDB2/BAX/BAK1/PIK3CD/BIRC3/CKS1B/RELA/RXRA/CHUK/TP53/AKT1/IKBKB/APAF1/CDK2/TRAF3/CDK6/TRAF6/TRAF4/SKP2/IKBKG/FHIT/PIK3R1	2.93446365057388
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	15/2306	31/9376	1.96737822790476	HSPA5/SRP19/SPCS3/SRP54/SRP9/SEC11A/IMMP1L/SRPRB/SRP72/SEC61B/SRPRA/SPCS1/UBL4A/SEC61A2/SEC61G	3.0810098420897
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	47/2306	133/9376	1.43682710679561	MDM2/GADD45A/RBL2/BCL2L11/KRAS/SOS2/CDKN2D/CCND2/EP300/MAPK1/PLK2/ATM/MAP2K1/CDKN1B/ATG12/AGAP2/SIRT1/MAP2K2/STAT3/GABARAPL2/RAF1/USP7/SMAD4/PTEN/PIK3CA/SOS1/GRB2/BRAF/CAT/S1PR4/PIK3CD/NRAS/FASLG/CCNG2/PRKAG1/MAPK9/CHUK/AKT1/MAPK8/IKBKB/CDK2/STK4/STK11/SKP2/CCNB1/ARAF/PIK3R1	2.89757380559793
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	20/2306	46/9376	1.76778913232022	PSMD12/PSMA2/PSMB8/PSMB9/PSMA5/PSMD13/PSMA6/PSMA1/PSMB2/PSMD6/PSMC4/PSMC6/PSME2/PSMA3/PSMB3/PSME4/PSMD11/PSMC2/PSMD9/PSMB1	2.98116241583296
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	57/2306	168/9376	1.37950687647132	CASP8/EIF2AK2/PPID/CYLD/CASP1/RBCK1/ZBP1/CAMK2D/PYCARD/CHMP5/VDAC3/VDAC2/BCL2/CAPN2/STAT4/DNM1L/BID/IFNGR1/BIRC2/STAT1/TRAF5/STAT3/VDAC1/TRPM7/GLUD1/HSP90AB1/IRF9/JAK3/BAX/SLC25A5/MLKL/HMGB1/SPATA2L/CHMP4A/CAMK2G/BIRC3/PGAM5/FASLG/JAK2/TNFRSF10A/AIFM1/RIPK1/MAPK9/JAK1/MAPK8/HSP90AA1/TRADD/CHMP7/PYGM/FAS/TYK2/TNFRSF10B/USP21/SPATA2/FADD/PPIA/TNFAIP3	2.83463547424037
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	50/2306	144/9376	1.4117760431724	GTF2B/PSMD12/PSMA2/OPA1/ATP2A2/PSMA5/CYCS/VDAC3/VDAC2/ITPR1/NRBF2/XBP1/ATXN2L/PSMD13/TBPL1/PSMA6/PSMA1/VDAC1/ERN1/PSMB2/PSMD6/PSMC4/ATXN10/PSMC6/PIK3CA/SLC25A5/OMA1/PSMA3/PSMB3/PUM2/PIK3CD/PSMD11/ATXN1L/PSMC2/PSMD9/ATXN3/MAPK9/PLCB2/AKT1/MAPK8/TBP/MTOR/PSMB1/ATG2B/KAT5/PLCB1/NFYA/PLCB3/PIK3R4/PIK3R1	2.8438062673473
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	28/2306	71/9376	1.60345943832989	GLS/HIF1A/KRAS/SLC1A5/MAPK1/MAP2K1/LDHB/IDH2/PDHA1/SLC7A5/MAP2K2/RAF1/SLC16A3/PTEN/PIK3CA/PFKP/PIK3CD/PDHB/TIGAR/NRAS/TP53/AKT1/MTOR/PDK1/LDHA/KIT/SIRT3/PIK3R1	2.91490666069993
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	8/2306	13/9376	2.50210154113016	XRCC5/XRCC6/PRKDC/XRCC4/FEN1/DCLRE1C/MRE11/LIG4	3.0950597604412
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	31/2306	82/9376	1.53711420895649	KLRC1/KLRC2/B2M/HSPA5/KLRD1/HSPA4/TAP1/HSPA8/CALR/KLRC3/PDIA3/HSPA1A/KLRC4/HLA-F/KIR2DL3/HSP90AB1/HLA-B/PSME2/TAP2/HLA-A/RFXANK/KIR2DL4/RFXAP/RFX5/HSPA1B/HSP90AA1/CD8A/NFYA/HSPA6/NFYB/KIR2DL1	2.78983049004929
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	40/2306	112/9376	1.45211250154875	SOCS1/CASP8/CASP3/PIK3R6/GNAI3/IL10RA/HSPA8/PIK3CG/CYCS/MAPK1/MAP2K3/HSPA1A/BCL2/IFNGR1/BIRC2/NFKB1/STAT1/STAT3/CASP9/IRAK4/BIRC3/JAK2/MYD88/RELA/MAP2K6/MAPK9/HSPA1B/GNAI2/JAK1/CHUK/AKT1/MAPK8/IKBKB/IRAK1/TYK2/TAB1/TRAF6/IKBKG/HSPA6/MAP3K7	2.74891832858439
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	60/2306	181/9376	1.34781712850934	ITGAX/CASP8/CASP3/MALT1/FCER1G/HSPD1/CASP10/IL18/CAMK2D/IL10RA/SYK/ARHGEF12/HSPA9/EP300/CYCS/PPP3CA/MAPK1/PPP3CC/BCL2/BID/IFNGR1/NFKB1/STAT1/RAB5A/BCL10/ITGAM/TCIRG1/CASP9/IRAK4/RAF1/ATP6V1H/BAX/PPP3R1/CEBPG/RFXANK/CALM3/CALM1/CORO1A/CAMK2G/JAK2/MYD88/RELA/RFXAP/RFX5/MAPK9/KSR1/JAK1/AKT1/MAPK8/APAF1/NOD2/IRAK1/TRADD/TLR1/TRAF6/SPHK2/RHOA/FADD/NFYA/NFYB	2.69848475435191
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	41/2306	116/9376	1.43709064808446	ME2/HIBCH/PGP/SUCLA2/SUCLG2/PGK1/SDHA/IDH2/MDH1/PDHA1/SDHD/ECHS1/GLUD1/SUCLG1/SDHB/DLST/IDH3A/ADPGK/PCCA/PFKP/DLD/CAT/RPIA/PDHB/PRPS1/RPE/SHMT2/FH/ALDH6A1/ACAT2/DLAT/CS/ENO1/ACADS/ALDOA/ACOX3/TKFC/PCCB/GOT1/SHMT1/GPT2	2.70520759808625
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	32/2306	86/9376	1.51289860626475	CAMK2D/KRAS/SOS2/MAPK1/MAP2K1/CDKN1B/MAP2K2/RAF1/PIK3CA/SOS1/GRB2/BRAF/AREG/PIK3CD/GAB1/RPS6KB1/NRAS/CBLB/NCK1/CAMK2G/MAP2K4/MAPK9/RPS6KB2/CRKL/AKT1/GSK3B/MAPK8/MTOR/ELK1/NCK2/ARAF/PIK3R1	2.72884250012441
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	31/2306	83/9376	1.51859476065581	ECI2/FAR1/SLC27A2/SCP2/AGPS/IDH2/PEX2/GSTK1/HSD17B4/ECH1/PEX6/CAT/ABCD3/CROT/NUDT19/ACSL3/PEX3/PMVK/PEX13/ACOT8/PECR/SOD1/PHYH/PXMP2/HACL1/MLYCD/PXMP4/DHRS4/ABCD2/PEX14/ACOX3	2.71015908932788
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	27/2306	70/9376	1.56828150167266	HIF1A/KRAS/SOS2/EP300/RAP1A/MAPK1/MAP2K1/CDC42/CUL2/MAP2K2/RAF1/PIK3CA/SOS1/GRB2/PRCC/BRAF/PIK3CD/GAB1/NRAS/FH/ARNT/CRKL/AKT1/ETS1/FLCN/ARAF/PIK3R1	2.72543982760448
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	30/2306	80/9376	1.52471812662619	BCL2L11/KRAS/SOS2/EIF4E/MAPK1/BCL2/MAP2K1/MAP2K2/STAT3/EIF4E2/RAF1/PTEN/PIK3CA/SOS1/BAX/GRB2/BRAF/PIK3CD/NF1/GAB1/RPS6KB1/NRAS/JAK2/RPS6KB2/JAK1/AKT1/GSK3B/MTOR/ARAF/PIK3R1	2.6917119718375
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	33/2306	90/9376	1.49083550159005	PRKACB/SESN1/KRAS/EIF4E/SESN2/NFKB1/SIRT1/ATG5/ATF6B/ATF2/EHMT1/EIF4E2/ADCY7/PIK3CA/BAX/APPL1/CAT/PIK3CD/RPS6KB1/NRAS/CAMK4/PRKAG1/EHMT2/RELA/RPS6KB2/TP53/AKT1/ADCY3/MTOR/TSC1/STK11/ADCY6/PIK3R1	2.67207390040835
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/2306	105/9376	1.4327510015281	GADD45A/MALT1/CYLD/SYK/TRIM25/ATM/BCL2/BIRC2/NFKB1/TRAF5/ZAP70/BCL10/CARD11/UBE2I/IRAK4/TNFSF14/CSNK2A1/LAT/CSNK2A2/BIRC3/MYD88/RELA/CSNK2B/RIPK1/CHUK/IKBKB/TRAF3/IRAK1/TRADD/TNFSF11/TAB1/TRAF6/PIAS4/IKBKG/LCK/MAP3K7/TNFAIP3	2.5466837868414
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/2306	14/9376	2.32338000247801	B4GALT1/B3GNT7/FUT8/B3GNT2/B4GALT4/ST3GAL3/B4GALT3/ST3GAL2	2.8298919254286
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	24/2306	62/9376	1.57390258232381	PRKACB/KRAS/HSPA8/HDAC1/HSPA1A/SIRT1/ATG5/ADCY7/PIK3CA/CAT/PIK3CD/RPS6KB1/NRAS/PRKAG1/SOD1/RPS6KB2/HSPA1B/AKT1/ADCY3/MTOR/HSPA6/ADCY6/CLPB/PIK3R1	2.58923512319865
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2306	37/9376	1.75823351538876	GADD45A/LEF1/KRAS/MAPK1/CTNNB1/MAP2K1/MAP2K2/DDB2/BAX/BAK1/BRAF/NRAS/TCF7/RXRA/TP53/TPM3	2.63912058564999
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	73/2306	232/9376	1.27936118670933	ITGAX/ARHGEF6/RAC2/RRAS2/PIP4K2A/ARPC5L/ACTR3/ITGB7/KRAS/SOS2/ARHGEF12/ARHGEF1/ACTR2/PPP1CB/PPP1CC/MAPK1/MSN/MAP2K1/CDC42/ARPC1B/FGD3/VAV3/GNA13/TMSB4X/MAP2K2/ARHGEF7/ITGAM/ARPC3/MYL12A/SPATA13/RAF1/LIMK1/PIKFYVE/ABI2/PIK3CA/IQGAP2/CYFIP2/NCKAP1L/SOS1/DIAPH1/PPP1R12A/PXN/BRAF/MYL12B/VAV1/PIK3CD/ROCK1/BRK1/NRAS/ACTN4/PIP4K2C/TIAM1/ITGA4/IQGAP1/ITGAD/CRKL/SSH2/AKT1/EZR/ARPC5/GIT1/PIP5K1A/MRAS/LPAR2/CFL1/ARPC2/RHOA/FGF22/PIP4K2B/ARAF/WASF1/ACTR3C/PIK3R1	2.46063690548181
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	33/2306	93/9376	1.44274403379683	PRKACB/CAMK2D/KRAS/SOS2/MAPK1/MAP2K3/MAP2K1/ITPR1/CDC42/MAP2K2/PTK2B/RAF1/ADCY7/SOS1/MAP3K1/GRB2/CALM3/MAP3K4/NRAS/CALM1/CAMK2G/MAP2K6/MAP2K4/MAPK9/PLCB2/MAPK8/ADCY3/ELK1/PLCB1/PRKCD/GNRH1/PLCB3/ADCY6	2.45050503616463
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/2306	23/9376	1.94456804555225	IDI1/HMGCS1/FNTA/ZMPSTE24/NUS1/HMGCR/PMVK/ACAT2/GGPS1/PDSS2/PDSS1	2.5901641199867
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	43/2306	128/9376	1.3658933217693	HPRT1/GMPS/ATIC/PAICS/NTPCR/DCK/PPAT/NME3/DGUOK/PGM2/ADCY7/NT5C2/NME7/GART/ENTPD4/PNP/NUDT2/NUDT5/PDE7A/PRPS1/NME1/AK2/PGM1/ADSL/NT5C/PAPSS1/NUDT9/APRT/AMPD2/NUDT16/ADCY3/AMPD3/RRM2B/AK6/IMPDH1/ADK/AK9/NME6/PDE6D/AK4/GUCY2D/FHIT/ADCY6	2.38035175802037
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	61/2306	193/9376	1.28508194437579	PRKACB/XCL1/RAC2/PIK3R6/CCR1/ITK/FGR/GNAI3/XCL2/KRAS/SOS2/PIK3CG/DOCK2/RAP1A/MAPK1/MAP2K1/CDC42/NFKB1/VAV3/STAT1/GNG5/STAT3/PTK2B/ARRB2/RAF1/ADCY7/JAK3/GRK2/GNGT2/PIK3CA/WAS/SOS1/GRB2/PXN/CXCR3/CCL28/BRAF/VAV1/PIK3CD/ROCK1/NRAS/JAK2/RELA/TIAM1/GNAI2/CHUK/CRKL/PLCB2/AKT1/GSK3B/ADCY3/IKBKB/PREX1/PLCB1/PRKCD/RHOA/GNG10/IKBKG/PLCB3/ADCY6/PIK3R1	2.28539702301397
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	50/2306	154/9376	1.32010227413523	GCH1/MTHFD2/MAT2A/ALAS1/ALDH3A2/PANK2/MTHFD1/MTHFD2L/GUSB/NME3/CTPS1/UGP2/CMPK2/RFK/NME7/GGCX/DLD/PANK3/PPCS/PPCDC/NME1/UMPS/PHOSPHO2/AK2/RDH11/SHMT2/MAT2B/ADSL/COX10/PMM2/LIAS/DHFR/AK6/PPOX/COQ5/GMPPA/AK9/NME6/GSS/AK4/BCAT2/CPOX/MMAB/TPK1/COX15/SHMT1/FECH/GPHN/DHODH/CAD	2.28740014243162
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	36/2306	106/9376	1.38087679392561	MDM2/LEF1/KRAS/SOS2/EP300/MAPK1/CTNNB1/BCL2/MAP2K1/CDKN1B/NFKB1/MAP2K2/CASP9/RB1/HSP90AB1/RAF1/PTEN/PIK3CA/SOS1/GRB2/BRAF/PIK3CD/NRAS/RELA/TCF7/CHUK/TP53/AKT1/GSK3B/IKBKB/CDK2/MTOR/HSP90AA1/IKBKG/ARAF/PIK3R1	2.25218032983929
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/2306	30/9376	1.76189650187916	ATIC/NFKB1/GART/SHMT2/RELA/CHUK/IKBKB/ABCC5/DHFR/ABCC1/TYMS/IKBKG/SHMT1	2.38698286475925
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	35/2306	103/9376	1.38162160341532	CASP8/GNAI3/CD3E/CALR/MAPK1/IFNGR1/NFKB1/PPP2R2B/PPP2R2A/PPP2CA/IRAK4/PIK3CA/PIK3CD/CD247/FASLG/MYD88/RELA/MAP2K4/MAPK9/GNAI2/PPP2R1B/CHUK/PLCB2/AKT1/MAPK8/IKBKB/PPP2R2D/IRAK1/FAS/TRAF6/PLCB1/FADD/IKBKG/PLCB3/PIK3R1	2.22406265191435
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	48/2306	149/9376	1.30982496783995	AGPAT5/RRAS2/PIK3R6/FCER1G/ARF6/KRAS/SOS2/SYK/DGKZ/PIK3CG/CYTH4/MAPK1/MAP2K1/GNA13/MAP2K2/PTK2B/ARF1/RAF1/ADCY7/DGKD/CYTH1/PIK3CA/SOS1/GRB2/DGKE/PIK3CD/GAB1/NRAS/DGKH/DNM2/PLCB2/CYTH2/AKT1/ADCY3/MTOR/PIP5K1A/TSC1/LPAR3/MRAS/LPAR2/FYN/SPHK2/PLCB1/RHOA/PLCB3/ADCY6/KIT/PIK3R1	2.1771325452104
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	46/2306	142/9376	1.31712739577098	SOCS1/CYLD/SYK/ATP2A2/LCP2/PPP3CA/MAPK1/PPP3CC/MAP2K1/ITPR1/IFNGR1/NFKB1/STAT1/CSF1/TEC1/IRF9/PIK3CA/PPP3R1/GRB2/PIK3CD/CAMK4/JUND/RELA/MAP2K6/MAPK9/JAK1/CHUK/SIRPG/AKT1/MAPK8/IKBKB/TYROBP/NCF4/NFATC2/TMEM64/TYK2/TNFSF11/TAB1/TRAF6/FYN/FOSL2/IKBKG/LCK/MAP3K7/PIK3R1/LILRA2	2.17464605338605
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/2306	56/9376	1.52471812662619	B4GALT1/MGAT5/ALG13/FUT8/STT3B/MGAT4A/DDOST/DAD1/OSTC/MOGS/TMEM258/ALG8/DPM1/ALG2/ALG11/ALG6/MAN1B1/B4GALT3/DPAGT1/ALG10B/ALG10	2.24914630828305
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	40/2306	122/9376	1.33308688666771	SOCS1/PRKACB/GNAI3/KRAS/SOS2/EP300/MAPK1/MAP2K3/MAP2K1/ITPR1/STAT1/MAP2K2/STAT3/ATF6B/SOCS2/ATF2/RAF1/ADCY7/PIK3CA/SOS1/MAP3K1/GRB2/PIK3CD/NRAS/JAK2/MAP2K6/MAP2K4/MAPK9/GNAI2/CRKL/PLCB2/AKT1/GSK3B/MAPK8/ADCY3/MTOR/PLCB1/PLCB3/ADCY6/PIK3R1	2.11484374832807
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2306	28/9376	1.74253500185851	HACD4/ACAA2/HADH/THEM4/ECHS1/HADHB/ACOT7/ELOVL6/HACD1/ACOT4/HACD2/ACOT2	2.24720233253333
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	72/2306	238/9376	1.23002470719424	RPS10/MX1/OAS2/RPL36A/RPS21/RPL26/RPL37/OAS1/RPS19/EIF2AK2/TBK1/RPL22L1/CASP1/RPS15A/SYK/RPL41/RSL24D1/MAPK1/RPL17/ADAR/NFKB1/STAT1/STAT3/IRAK4/RPL14/IRF9/RPL39/PIK3CA/OAS3/MX2/RPL30/RPL3/RPS23/PIK3CD/RPS29/FAU/RPS7/RPS18/MYD88/RELA/RPL32/RPL34/RPS27L/MAPK9/JAK1/CHUK/MAPK8/IKBKB/RPL27/RPS25/TRAF3/IRAK1/CGAS/RPS24/ISG15/RPL7A/RPL35A/TYK2/TRAF6/RPLP1/RPS3/RPL23A/IKBKG/RPS4X/RPL35/RPL24/RPS27/MAP3K7/RPL36AL/RPL15/PIK3R1/RPS27A	2.05278266220388
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	21/2306	57/9376	1.49796868580819	HACD4/ACAA2/HADH/SCP2/ECHS1/ACADM/HADHB/HSD17B4/ACADVL/ELOVL6/HACD1/ACSL3/CBR4/ACAT2/ACACA/ACADSB/CPT1A/HACD2/ACADS/ACOX3/MCAT	2.15357692022276
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	36/2306	109/9376	1.34287101060656	CASP8/IRF7/TBK1/MAP3K8/MAPK1/MAP2K3/MAP2K1/NFKB1/STAT1/MAP2K2/IRAK4/IRF9/PIK3CA/PIK3CD/MYD88/RELA/MAP2K6/RIPK1/MAP2K4/MAPK9/JAK1/CHUK/AKT1/MAPK8/IKBKB/TRAF3/IRAK1/TLR1/TYK2/TAB1/TRAF6/FADD/IKBKG/IRF5/MAP3K7/PIK3R1	2.05626942396641
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	15/2306	38/9376	1.6049664490802	TAP1/CD3E/PTPRC/ZAP70/JAK3/TAP2/RFXANK/RFXAP/RFX5/DCLRE1C/IL2RG/ORAI1/CD8A/IKBKG/LCK	2.13403597325189
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	97/2306	333/9376	1.18436563189382	MX1/OASL/CCND3/PRKACB/CASP8/MDM2/CASP3/EIF2AK2/RBL2/TBK1/PPP2R5A/ITGB7/KRAS/SOS2/PATJ/CSNK1A1/CCND2/EP300/TADA3/MAML3/MAPK1/CTNNB1/HDAC1/ATM/MAP2K1/CDKN1B/UBE3A/CDC42/NFKB1/HLA-F/TBPL1/STAT1/JAG1/MAP2K2/PPP2R2B/TCIRG1/ATP6V1G1/PPP2R2A/COL9A2/PPP2CA/RB1/ATP6V1D/RAF1/HLA-B/IRF9/PTEN/ATP6V1H/PIK3CA/ATP6V0E2/ATR/SOS1/MX2/BAX/GRB2/BAK1/NOTCH2/IRF1/PPP2R3C/PXN/HLA-A/PIK3CD/RPS6KB1/NRAS/LLGL2/FASLG/HES6/RELA/TCF7/RBL1/ITGA4/RPS6KB2/LFNG/JAK1/PPP2R1B/CHUK/TP53/AKT1/GSK3B/IKBKB/TBP/CDK2/PPP2R2D/MTOR/TRAF3/TRADD/NOTCH1/TSC1/CDK6/ISG15/FAS/TYK2/FADD/IKBKG/COL9A3/PARD6B/PIK3R1/WNT11	1.95637182819752
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	88/2306	300/9376	1.19266840127204	PRKACB/GADD45A/RASA2/CASP3/RAC2/PTPN7/RRAS2/DUSP10/DDIT3/MKNK2/KRAS/HSPA8/MAP3K8/SOS2/RAP1A/PPP3CA/MAPK1/PPP3CC/ELK4/MAP2K3/PPM1B/HSPA1A/MAP2K1/CDC42/DUSP2/NFKB1/MAP2K2/MAPKAPK3/MKNK1/LAMTOR3/RASGRP1/ATF2/CSF1/IRAK4/ARRB2/DUSP5/RPS6KA3/RAF1/SOS1/PPP3R1/MAP3K1/GRB2/DUSP6/PPM1A/BRAF/AREG/NF1/MAP3K4/RPS6KA5/NRAS/RPS6KA1/JUND/NFATC3/MAPKAPK5/FASLG/MYD88/RELA/MAP2K6/MAP2K4/MAPK9/HSPA1B/MAP4K1/CHUK/CRKL/TP53/AKT1/MAPK8/IKBKB/MAP3K12/STK4/IRAK1/MAP3K21/TRADD/ELK1/MRAS/FAS/TAB1/TRAF6/STMN1/FGF22/EFNA5/MAP4K3/IKBKG/HSPA6/MAP3K7/ARAF/KIT/MAP3K10	1.93699928421195
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2306	32/9376	1.65177797051171	ATG12/IGBP1/ATG5/ATG16L1/PPP2CA/GABARAPL2/ATG3/ATG4A/MTOR/ATG2B/ATG4D/PIK3R4/ATG4C	2.10918092343562
Organismal Systems	Immune system	hsa04611	Platelet activation	40/2306	126/9376	1.29076666804334	PRKACB/PIK3R6/FCER1G/GNAI3/SYK/ARHGEF12/PIK3CG/ARHGEF1/LCP2/RAP1A/PPP1CB/PPP1CC/MAPK1/ITPR1/VASP/STIM1/GNA13/MYL12A/RASGRP1/ADCY7/PIK3CA/SNAP23/PPP1R12A/VAMP8/FERMT3/MYL12B/PIK3CD/ROCK1/GNAI2/PLCB2/AKT1/ADCY3/P2RY1/ORAI1/FYN/PLCB1/RHOA/PLCB3/ADCY6/PIK3R1	1.87656930707071
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	46/2306	148/9376	1.26373033918567	GADD45A/LEF1/KRAS/SOS2/CSNK1A1/MAPK1/CTNNB1/MAP2K1/JAG1/MAP2K2/RB1/RAF1/PTEN/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/NOTCH2/NCOA3/BRAF/PIK3CD/JAG2/RPS6KB1/NRAS/NCOA1/TCF7/RPS6KB2/FRAT2/TP53/AKT1/GSK3B/MTOR/DLL1/NOTCH1/CDK6/BRCA2/TNFSF11/FGF22/BRCA1/ARAF/KIT/PIK3R1/FRAT1/WNT11	1.84689727652964
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/2306	63/9376	1.41984333484767	HADH/GCDH/ALDH3A2/NSD1/NSD2/EZH2/ECHS1/SETD2/EHMT1/DLST/PHYKPL/NSD3/DLD/SETDB1/SMYD3/EHMT2/ACAT2/COLGALT2/SUV39H2/KMT5C/CAMKMT/TMLHE	1.90949409217167
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	13/2306	33/9376	1.60172409261741	IDH2/PDHA1/DLST/IDH3A/DLD/PDHB/BCKDHB/DLAT/CS/DBT/BCAT2/GOT1/GPT2	1.97750130598344
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	21/2306	60/9376	1.42307025151778	RAC2/KRAS/PPP3CA/MAPK1/PPP3CC/MAP2K1/CDC42/MAP2K2/MAPKAPK3/CASP9/RAF1/PIK3CA/PPP3R1/PXN/SH2D2A/PIK3CD/NRAS/AKT1/NFATC2/SPHK2/PIK3R1	1.87749572466333
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/2306	99/9376	1.31423515291685	RAC2/HIF1A/SLC44A1/KRAS/SOS2/DGKZ/MAPK1/MAP2K1/MAP2K2/GPCPD1/RAF1/DGKD/PIK3CA/WAS/SOS1/GRB2/LYPLA1/DGKE/PIK3CD/RPS6KB1/NRAS/DGKH/MAPK9/RPS6KB2/AKT1/MAPK8/MTOR/PIP5K1A/TSC1/CHKB/WASF1/PIK3R1	1.79504015814079
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	48/2306	157/9376	1.24308229431944	PTGER2/CASP3/CD47/HIF1A/CASP1/CAMK2D/ODC1/ATP11B/ATP8A1/CALR/TMEM30A/ATP2A2/MAPK1/MAP2K1/UQCRFS1/DUSP2/RAB5A/SIRT1/ANO6/MAP2K2/RAB14/ADAM10/DUSP5/HAVCR2/PTPN6/DNMT3A/XKR6/CAMK2G/NFATC3/JAK2/VPS33A/VPS8/RXRA/VPS41/VPS11/ARNT/SIRPG/CRKL/ARG2/CASP7/PLA2G6/NFATC2/ANO9/VPS39/SPHK2/CPT1A/GPR132/PPARD	1.75415040579228
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/2306	21/9376	1.74253500185851	ALDH3A2/PANK2/AASDHPPT/PANK3/PPCS/PPCDC/DPYD/CSAD/BCAT2	1.9454060610524
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/2306	110/9376	1.29370022865253	HIF1A/MKNK2/CAMK2D/EIF4E/EP300/MAPK1/BCL2/MAP2K1/LDHB/PGK1/CDKN1B/IFNGR1/NFKB1/CUL2/PDHA1/MAP2K2/STAT3/MKNK1/EIF4E2/PIK3CA/PFKP/PIK3CD/PDHB/RPS6KB1/CAMK2G/RELA/ARNT/RPS6KB2/AKT1/MTOR/ENO1/ALDOA/PDK1/LDHA/PIK3R1	1.76953868742478
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/2306	41/9376	1.48752987963531	MDM2/KRAS/RASSF1/MAPK1/MAP2K1/DAPK2/MAP2K2/RB1/RAF1/CDKN2A/BRAF/RPS6KA5/NRAS/TP53/ARAF	1.78665865612043
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	60/2306	204/9376	1.19585735421662	PRKACB/MDM2/CASP3/RRAS2/HIF1A/DDX5/CAMK2D/KRAS/SOS2/ARHGEF12/ARHGEF1/NUDT16L1/PPP1CB/PPP1CC/MAPK1/CTNNB1/MSN/MAP2K1/ITPR1/CDC42/VAV3/HCLS1/MAP2K2/PDCD4/STAT3/RAF1/PIK3CA/PTPN6/SOS1/GRB2/PPP1R12A/PXN/BRAF/VAV1/PIK3CD/EIF4B/GAB1/ROCK1/RPS6KB1/NRAS/CAMK2G/FASLG/TIAM1/IQGAP1/RPS6KB2/TP53/AKT1/EZR/MTOR/ELK1/MRAS/CD44/TFAP4/FAS/ANK2/RHOA/ARAF/HPSE/PIK3R1/WNT11	1.61520826012281
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	8/2306	19/9376	1.71196421235222	PDHA1/DLST/DLD/PDHB/BCKDHB/DLAT/LIAS/DBT	1.77407604779919
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/2306	56/9376	1.37950687647132	CUL1/PRKACB/CUL3/SMURF2/CSNK1A1/CCND2/BCL2/CSNK1G3/ARRB2/CSNK1D/GRK2/CSNK1G2/KIF3A/GSK3B/CSNK1G1/BTRC/EFCAB7/SMURF1/MOSMO	1.62671431930838
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/2306	39/9376	1.45955923232593	MTHFD2/MAT2A/ATIC/MTHFD1/MTHFD2L/GART/DLD/MTHFS/SHMT2/MAT2B/DHFR/AHCYL2/TYMS/SHMT1	1.6423877691517
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	25/2306	78/9376	1.30317788600529	ARPC5L/ACTR3/ACTR2/CTNNB1/CDC42/ARPC1B/HCLS1/ARPC3/PIK3CA/CD2AP/PXN/MAD2L2/PIK3CD/GAB1/DNM2/ARHGAP10/ELMO2/CRKL/ARPC5/ARHGEF26/ARPC2/RHOA/WASF1/ACTR3C/PIK3R1	1.53552055203224
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/2306	43/9376	1.4183424433732	ECI2/ACAA2/HADH/GCDH/ALDH3A2/ECHS1/ACADM/HADHB/ACADVL/ACSL3/ACAT2/ACADSB/CPT1A/ACADS/ACOX3	1.57022217504958
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	50/2306	170/9376	1.19585735421662	DPF3/GADD45A/LEF1/SMARCE1/KRAS/SOS2/CSNK1A1/SMARCA2/MAPK1/CTNNB1/TXNRD1/MAP2K1/BRD7/GSTM2/MAP2K2/PHF10/PBRM1/ARID2/SMARCB1/RB1/RAF1/SMAD4/CDKN2A/PTEN/SMARCC2/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/PIK3CD/GAB1/RPS6KB1/NRAS/ACTL6A/TCF7/RPS6KB2/FRAT2/TP53/AKT1/GSK3B/MTOR/CDK6/ELK1/ARAF/PIK3R1/FRAT1/WNT11	1.4717513458782
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	43/2306	144/9376	1.21412739712826	CASP8/TRA2A/CASP3/LEF1/TBK1/CTNNB1/MAP2K3/NFKB1/ALDH3A2/LPIN1/SIRT1/ACADM/IRAK4/ACADVL/TRA2B/FASLG/PRKAG1/MYD88/RELA/TCF7/MAP2K6/RIPK1/MAP2K4/MAPK9/CHUK/AKT1/GSK3B/MAPK8/IKBKB/TRAF3/IRAK1/TRADD/SREBF1/ACACA/MLYCD/FAS/TAB1/TRAF6/CPT1A/FADD/IKBKG/ACOX3/MAP3K7	1.47880588018855
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	52/2306	178/9376	1.18779539452527	CACYBP/CUL1/CCND3/PRKACB/CCDC88C/LEF1/RAC2/CAMK2D/CSNK1A1/CCND2/EP300/PPP3CA/CTNNB1/TBL1XR1/PPP3CC/SIRT1/CHD8/CTNNBIP1/SENP2/SMAD4/TLE3/RYK/SKP1/PPP3R1/CSNK2A1/CSNK2A2/RUVBL1/CAMK2G/NFATC3/TCF7/CSNK2B/SIAH1/MAPK9/FRAT2/TP53/PLCB2/GSK3B/MAPK8/INVS/NFATC2/BTRC/PLCB1/RHOA/TLE1/SOST/PLCB3/CCAR2/PPARD/MAP3K7/PORCN/FRAT1/WNT11	1.44462065077209
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	18/2306	54/9376	1.3553050014455	MAT2A/AMD1/LDHB/MDH1/DNMT1/SMS/MPST/MTAP/DNMT3A/APIP/MAT2B/ENOPH1/MRI1/AHCYL2/GSS/BCAT2/GOT1/LDHA	1.49537196487667
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/2306	20/9376	1.62636600173461	LBR/MSMO1/CYP51A1/SQLE/EBP/FDFT1/HSD17B7/DHCR24	1.60141411036807
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/2306	30/9376	1.49083550159005	PIGK/PIGN/PIGS/PIGC/PIGG/PIGB/PGAP1/PGAP2/PIGL/PIGA/PIGV	1.53776258169092
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/2306	27/9376	1.50589444605056	HACD4/SCP2/HSD17B4/ACOT7/ELOVL6/HACD1/ACOT4/HACD2/ACOX3/ACOT2	1.50336625083029
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	20/2306	62/9376	1.31158548526984	EP300/MAML3/HDAC1/JAG1/SNW1/DTX3L/ITCH/TLE3/NOTCH2/JAG2/NUMB/ATXN1L/LFNG/KAT2B/DLL1/NOTCH1/KAT2A/PSEN2/TLE1/DTX3	1.40575788851281
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	41/2306	139/9376	1.19929867034386	PRKACB/FKBP5/GNAI3/KRAS/HSPA8/SOS2/FKBP4/MAPK1/HSPA1A/BCL2/MAP2K1/ITPR1/MAP2K2/ATF6B/ATF2/HSP90AB1/RAF1/ADCY7/PIK3CA/SOS1/GRB2/NCOA3/CALM3/PIK3CD/NRAS/CALM1/NCOA1/HSPA1B/GNAI2/PLCB2/AKT1/ADCY3/HSP90AA1/RARA/PLCB1/POMC/PRKCD/HSPA6/PLCB3/ADCY6/PIK3R1	1.35192286197451
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/2306	73/9376	1.28104171369507	MDM2/GADD45A/KRAS/MAPK1/MAP2K1/MAP2K2/RB1/RAF1/CDKN2A/PTEN/PIK3CA/DDB2/BAX/BAK1/BRAF/PIK3CD/NRAS/TP53/AKT1/CDK6/FGF22/ARAF/PIK3R1	1.37665871151309
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/2306	18/9376	1.58118916835309	MMADHC/THAP11/CD320/LMBRD1/HCFC1/MMAB/ZNF143	1.40950891356126
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	32/2306	109/9376	1.19366312053916	OGT/PPP1R3B/SLC27A2/PPP1CB/PPP1CC/NFKB1/STAT3/RPS6KA3/PTEN/PIK3CA/MLX/OGA/PIK3CD/RPS6KB1/RPS6KA1/PRKAG1/RELA/MAPK9/RPS6KB2/AKT1/GSK3B/MAPK8/IKBKB/SLC27A5/MTOR/SLC27A3/SREBF1/PPP1R3E/PYGM/PRKCD/CPT1A/PIK3R1	1.16143838643611
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	40/2306	140/9376	1.161690001239	PRKACB/RRAS2/PIK3R6/GNAI3/KRAS/PIK3CG/MAP1LC3B/TFAM/MAPK1/MAP2K1/ITPR1/JAG1/GNA13/GNG5/MAP2K2/RAF1/SMAD4/ADCY7/GNGT2/CALM3/RPS6KB1/NRAS/CAMK4/CALM1/PRKAG1/RPS6KB2/GNAI2/PLCB2/AKT1/ADCY3/MTOR/HDAC5/MRAS/SPHK2/PLCB1/GNG10/PLCB3/PIK3R4/ADCY6/NRF1	1.10080603756489
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/2306	47/9376	1.2976324481925	ME2/LDHB/ALDH3A2/ACYP1/MDH1/PDHA1/DLD/GLO1/PDHB/FH/ACAT2/DLAT/HAGH/ACACA/LDHA	1.1682001075644
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/2306	44/9376	1.29370022865253	B4GALT1/ALG13/FUT8/STT3B/MGAT4A/DDOST/DAD1/OSTC/TMEM258/ALG2/ALG11/MAN1B1/ST3GAL3/B4GALT3	1.1151899336916
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/2306	115/9376	1.16674082733135	PRKACB/GNAI3/ARHGEF1/MAPK1/BCL2/MAP2K1/ITPR1/GATA3/GNA13/ATF6B/STK39/ATF2/ARRB2/RUNX2/RAF1/ADCY7/OXSR1/BRAF/JUND/RXRA/BGLAP/GNAI2/PLCB2/ADCY3/NACA/TNFSF11/PLCB1/RHOA/SOST/PLCB3/ADCY6/ARAF/NR4A2	1.02746612633873
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	68/2306	250/9376	1.10592888117953	FUCA1/VPS13C/GNPTAB/VPS26A/BLOC1S2/GGA2/CD164/AP1G1/IDS/CTSC/CTSA/AP1S3/OSTM1/STX17/CTSW/VPS13A/SPG11/IGF2R/TCIRG1/GUSB/ATP6V1G1/DMXL1/LAMTOR3/ATP6V1D/MANBA/SORT1/M6PR/PIKFYVE/OSBPL7/ATP6V1H/VPS29/SLC15A4/ATP6V0E2/AP5M1/AP3S1/LAPTM4B/OSBPL3/ENTPD4/MFSD8/VAMP8/VAMP7/LAPTM5/NEU1/PLEKHM1/VPS33A/AP3M1/VPS41/VPS11/AP1S1/CTBS/SNAPIN/TELO2/TTI1/MTOR/ABCA5/BORCS6/ABCA2/VPS39/BLOC1S4/TPCN2/CLN3/BLOC1S5/AP4S1/AP3S2/RRAGB/SLC36A4/AP4B1/AP4M1	0.969504301255393
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2306	31/9376	1.31158548526984	HIBCH/CNDP2/ALDH3A2/ECHS1/DPYD/ALDH6A1/CSAD/MLYCD/ACADS/ACOX3	0.992370842217457
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/2306	31/9376	1.31158548526984	PGP/MDH1/PCCA/DLD/CAT/SHMT2/ACAT2/CS/PCCB/SHMT1	0.992370842217457
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	30/2306	107/9376	1.13997616944014	PRKACB/CAMK2D/SIK1/EP300/PPP3CA/PPP3CC/ITPR1/LDHB/PDHA1/SIRT1/PPP4C/ATF2/PPP4R3A/PPP4R3B/PHKG2/PPP3R1/PFKP/CALM3/PDHB/CALM1/CAMK2G/PRKAG1/PLCB2/AKT1/ACACA/PYGM/PLCB1/CPT1A/PLCB3/LDHA	0.831639550616952
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	41/2306	150/9376	1.11135010118531	GADD45A/LEF1/ABCB1/KRAS/SOS2/CSNK1A1/MAPK1/CTNNB1/BCL2/MAP2K1/CDKN1B/MAP2K2/RB1/RAF1/SMAD4/PIK3CA/DDB2/SOS1/BAX/GRB2/BAK1/BRAF/PIK3CD/GAB1/RPS6KB1/NRAS/TCF7/RXRA/RPS6KB2/FRAT2/TP53/AKT1/GSK3B/CDK2/MTOR/MLH1/FGF22/ARAF/PIK3R1/FRAT1/WNT11	0.785118305283567
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	29/2306	104/9376	1.1337647608246	ETNK1/AGPAT5/DGKZ/LPIN1/GPCPD1/PGS1/LPGAT1/DGKD/PLPP5/SGMS1/LPCAT4/SELENOI/LYPLA2/LYPLA1/DGKE/SGMS2/MBOAT7/CRLS1/DGKH/PTDSS1/CDS2/PLA2G6/LPCAT3/PCYT2/GPD1L/CEPT1/PLB1/GPD2/CHKB	0.783388619795272
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	20/2306	70/9376	1.161690001239	NFKB1/STAT3/APPL1/ACSL3/JAK2/PRKAG1/RELA/RXRA/MAPK9/CHUK/AKT1/MAPK8/IKBKB/MTOR/TRADD/STK11/NFKBIE/POMC/CPT1A/IKBKG	0.775454361623829
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/2306	78/9376	1.14679653968466	CASP3/GNAI3/IRF8/CASP1/PYCARD/MAPK1/NFKB1/ITGAM/IRAK4/IRF1/CALM3/CALM1/MYD88/RELA/MAPK9/GNAI2/MAPK8/CASP7/IRAK1/TRAF6/CFL1/RHOA	0.743487945717365
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	26/2306	94/9376	1.1246147884335	CASP8/CASP3/TBK1/MAPK1/ANAPC5/SRSF1/NFKB1/TRAF5/HSP90AB1/ELAVL1/JUND/RELA/MAPK9/CHUK/GSK3B/MAPK8/IKBKB/HSP90AA1/TRAF3/TRADD/TRAF6/TRAF4/FADD/IKBKG/MAP3K7/TNFAIP3	0.693455044935377
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/2306	60/9376	1.15200925122868	GNAI3/KRAS/MAPK1/MAP2K1/ITPR1/GNA13/MAP2K2/PPP2CA/RAF1/BRAF/NRAS/GNAI2/PPP2R1B/PLCB2/PLCB1/PLCB3/ARAF	0.674584701399466
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	33/2306	122/9376	1.09979668150086	PPP2R5A/CAB39/RAB8A/SIRT1/PPP2R2B/PPP2R2A/PPP2CA/RAB14/RAB10/TBC1D1/PIK3CA/PPP2R3C/PFKP/ELAVL1/PIK3CD/RPS6KB1/PRKAG1/HMGCR/RPS6KB2/PPP2R1B/AKT1/STRADB/PPP2R2D/MTOR/SREBF1/TSC1/STK11/ACACA/MLYCD/CPT1A/STRADA/MAP3K7/PIK3R1	0.633631633137607
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	35/2306	130/9376	1.09466942424445	PRKACB/GNAI3/KRAS/SOS2/MAPK1/MAP2K1/NFKB1/GNG5/MAP2K2/ATF6B/ATF2/ARRB2/RAF1/ADCY7/GNGT2/PIK3CA/SOS1/GRB2/PIK3CD/NRAS/RELA/MAP2K4/MAPK9/GNAI2/PLCB2/AKT1/MAPK8/ADCY3/PLCB1/GNG10/RLN2/PLCB3/ADCY6/PIK3R1/RLN1	0.620740455027527
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/2306	15/9376	1.3553050014455	SLC33A1/ST6GALNAC4/ST6GALNAC6/B4GALNT1/ST3GAL2	0.786486750234282
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2306	15/9376	1.3553050014455	ACP1/NTPCR/AK2/AK4/TPK1	0.786486750234282
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/2306	99/9376	1.10888591027359	PRKACB/PTGER2/CAMK2D/PPP1CB/PPP1CC/MAP2K3/ITPR1/ADCY7/PIK3CA/CALM3/PIK3CD/TRPV2/CALM1/CAMK2G/PRKCH/MAP2K6/MAPK9/PLCB2/MAPK8/ADCY3/PLA2G6/PLCB1/PRKCD/PLCB3/ADCY6/PIK3R1/CYP2J2	0.62200100715191
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	45/2306	170/9376	1.07627161879496	PRKACB/ARPC5L/ACTR3/RAP2C/HSPA4/PATJ/WHAMM/RAB8B/TUBA4A/RAP1A/ACTR2/RAB8A/MSN/VASP/CDC42/ARPC1B/HCLS1/PPP2R2B/PPP2R2A/ARPC3/MYL12A/PPP2CA/WAS/MAP3K1/MYL12B/ROCK1/ACTN4/LLGL2/PRKAG1/PCNA/TIAM1/MAPK9/PPP2R1B/ARHGAP17/MAPK8/EZR/PPP2R2D/ARPC5/STK11/TUBA1B/ARPC2/RHOA/TJAP1/ACTR3C/PARD6B	0.57313578069495
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/2306	34/9376	1.19585735421662	CUL1/BHLHE40/PER2/CSNK1D/SKP1/NFIL3/CLOCK/PRKAG1/DBP/BTRC	0.653378731298153
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/2306	27/9376	1.20471555684045	HMGCS1/HADH/OXCT1/ECHS1/AACS/ACAT2/BDH1/ACADS	0.608353109184168
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	27/2306	101/9376	1.08692777343649	PRKACB/LEF1/GNAI3/CAMK2D/KRAS/EP300/MAPK1/CTNNB1/MAP2K1/MAP2K2/RAF1/ADCY7/CALM3/NRAS/CALM1/CAMK2G/TCF7/GNAI2/PLCB2/GSK3B/ADCY3/PLCB1/POMC/PLCB3/ADCY6/KIT/WNT11	0.501611940842069
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/2306	31/9376	1.18042693674286	PGM2/PFKP/RPIA/PRPS1/RPE/DERA/PGM1/ALDOA/RBKS	0.574643042243008
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/2306	20/9376	1.21977450130095	UAP1/UGP2/GMDS/CYB5R4/TGDS/GMPPA	0.561891907459524
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	29/2306	110/9376	1.07192304659781	ID3/CUL1/ID2/SMURF2/EP300/MAPK1/HDAC1/TFDP1/LEMD3/SKIL/PPP2CA/SMAD4/SKI/SKP1/SMAD5/NCOR1/ROCK1/RPS6KB1/SMAD7/RBL1/RPS6KB2/PPP2R1B/E2F4/SIN3A/BMPR1A/E2F5/RHOA/ACVR1B/SMURF1	0.433335084743326
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/2306	51/9376	1.11613353060218	PRKACB/ERO1A/TCIRG1/ATP6V1G1/ATP6V1D/ARF1/SEC61B/ATP6V1H/ATP6V0E2/PDIA4/ADCY3/SLC12A2/SEC61A2/SEC61G	0.47492374079188
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	61/2306	238/9376	1.04210426581734	PRKACB/RASA2/RAC2/RRAS2/TBK1/ARF6/KRAS/SOS2/RASSF1/RAP1A/SHOC2/RASSF5/MAPK1/RASAL3/MAP2K1/CDC42/NFKB1/RAB5A/ZAP70/GNG5/MAP2K2/RALGAPA1/RASGRP1/CSF1/RAF1/GNGT2/PIK3CA/SOS1/GRB2/BRAP/LAT/CALM3/PIK3CD/RALGAPA2/NF1/GAB1/NRAS/CALM1/FASLG/EXOC2/RELA/TIAM1/MAPK9/KSR1/CHUK/AKT1/MAPK8/IKBKB/STK4/PLA2G6/ELK1/MRAS/RGL2/ETS1/RHOA/FGF22/EFNA5/GNG10/IKBKG/KIT/PIK3R1	0.375746188002655
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	30/2306	115/9376	1.06067347939213	PRKACB/PIK3R6/GNAI3/CAMK2D/KRAS/PIK3CG/MAPK1/BCL2/MAP2K1/ITPR1/GNG5/ADCY7/GNGT2/PIK3CA/PIK3CD/NRAS/CAMK4/CAMK2G/JAK2/GNAI2/PLCB2/AKT1/ADCY3/FYN/PLCB1/GNG10/PLCB3/ADCY6/KCNQ5/PIK3R1	0.373873308896608
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	54/2306	212/9376	1.03565759544421	PRKD3/RAC2/GNAI3/KRAS/EVL/LCP2/RAP1A/RASSF5/MAPK1/CTNNB1/MAP2K3/MAP2K1/VASP/CDC42/VAV3/MAP2K2/ITGAM/SIPA1/RGS14/SKAP1/CSF1/RAF1/ADCY7/PIK3CA/BRAF/LAT/VAV1/SIPA1L1/CALM3/PIK3CD/NRAS/CALM1/TIAM1/MAP2K6/GNAI2/CRKL/PLCB2/AKT1/ADCY3/P2RY1/LPAR3/MRAS/LPAR2/PLCB1/RHOA/FGF22/EFNA5/PLCB3/SIPA1L3/ADCY6/FARP2/KIT/PARD6B/PIK3R1	0.299904530410118
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/2306	116/9376	1.05152974250082	RAC2/ITK/GNAI3/TXK/RHOH/RAP1A/RASSF5/CTNNB1/MSN/VASP/CDC42/VAV3/ITGAM/SIPA1/MYL12A/PTK2B/PIK3CA/PXN/MYL12B/VAV1/PIK3CD/ROCK1/ACTN4/ITGA4/GNAI2/EZR/CD99/NCF4/RHOA/PIK3R1	0.318923892678933
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	51/2306	201/9376	1.03165007572718	GZMB/MDM2/GADD45A/DDIT3/DDX5/ID2/ITGB7/FUT8/CDKN2C/CCND2/JMJD1C/ELK4/HDAC1/ATM/SS18/CDKN1B/TAF15/BIRC2/NFKB1/IL2RB/NSD2/ITGAM/KDM6A/PER2/RUNX2/CCNT2/CDK9/CCNT1/DDB2/SIX4/BAX/BAK1/HOXA9/DUSP6/SUPT3H/PRCC/NCOR1/FLI1/MLLT3/ETV6/BIRC3/HOXA10/RELA/RXRA/TP53/SIN3A/RARA/SS18L1/FUS/TCF3/LDB1	0.259045068234119
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/2306	49/9376	1.07871214400765	OGT/B4GALT1/GXYLT1/GALNT3/GALNT1/C1GALT1C1/C1GALT1/POGLUT1/LFNG/GALNT2/COLGALT2/ST3GAL3/B4GALT3	0.31548184829665
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/2306	101/9376	1.04667118923514	PIM1/CASP3/KRAS/MAPK1/BCL2/CDKN1B/CDC42/NFKB1/STAT1/STAT3/SMAD4/PIK3CA/BAX/DIAPH1/PIK3CD/NRAS/JAK2/RELA/MAPK9/PLCB2/AKT1/MAPK8/PLCB1/PRKCD/PLCB3/PIK3R1	0.269313533387005
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	23/2306	89/9376	1.05074207977236	PRKACB/GNAI3/KRAS/SOS2/TUBA4A/MAPK1/MAP2K1/ITPR1/MAP2K2/RAF1/ADCY7/CSNK1D/SOS1/GRB2/NRAS/GNAI2/PLCB2/ADCY3/TUBA1B/PLCB1/ADRB1/PLCB3/ADCY6	0.274682585783198
NA	NA	hsa04517	IgSF CAM signaling	75/2306	299/9376	1.01987834556936	ITGAX/SRGAP3/DOK2/ARPC5L/ACTR3/ARF6/NCAM1/SH2D1B/CD2/CD96/MBP/ICAM3/TUBA4A/LCP2/RAP1A/ACTR2/CASK/MAPK1/CTNNB1/MSN/MAP2K1/SPTAN1/CDC42/ARPC1B/VAV3/INPP5D/PLXNA4/MAP2K2/ITGAM/ARPC3/MYL12A/CSK/CRTAM/PIK3CA/PTPN6/CD2AP/GRB2/DYNLL1/SRGAP2/PXN/MYL12B/VAV1/PIK3CD/CD48/ACTN4/NCK1/ITGA4/SSX2IP/IQGAP1/MAPK9/AKT1/CABLES1/GSK3B/MAPK8/EZR/ARPC5/CD226/GIT1/NECTIN3/LMO7/MTSS1/TUBA1B/NECTIN1/TRAF6/FYN/ANK2/ARPC2/RHOA/NCK2/LCK/CD244/DOK1/ACTR3C/PARD6B/PIK3R1	0.1995033742516
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	42/2306	166/9376	1.0287254830249	PIK3R6/GNAI3/ATP2A2/PIK3CG/PPP3CA/PPP1CB/PPP1CC/VDAC3/MAPK1/VDAC2/PPP3CC/MAP2K1/ITPR1/VASP/GTF2I/GNA13/MAP2K2/VDAC1/ATP1A1/ATF6B/ATF2/RAF1/ADCY7/ATP1B1/PPP3R1/SLC25A5/PPP1R12A/CALM3/ROCK1/CALM1/NFATC3/GNAI2/PLCB2/AKT1/ADCY3/NFATC2/PLCB1/RHOA/ADRB1/PLCB3/ADCY6/KCNMB4	0.213253983259747
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2306	10/9376	1.21977450130095	MPST/PAPSS1/BPNT1	0.397105415081814
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/2306	18/9376	1.12942083453792	FUCA1/MANBA/NEU1/GBA2/NEU3	0.313873399255972
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/2306	71/9376	1.03079535321207	CASP3/CDC42/NFKB1/TCIRG1/ATP6V1G1/CSK/ADAM10/ATP6V1D/ATP6V1H/ATP6V0E2/RELA/MAP2K4/MAPK9/CHUK/MAPK8/IKBKB/GIT1/IKBKG	0.148751638461256
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/2306	55/9376	1.03496018292202	DEGS1/UGCG/SPTLC1/CERS2/B4GALT5/SGMS1/SGMS2/CERS5/NEU1/B4GALNT1/GBA2/SPHK2/B4GALT6/NEU3	0.148500997155353
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/2306	47/9376	1.038105958554	SOCS1/SOCS4/MAPK1/SOCS2/PIK3CA/PIK3CD/MAPK9/MAPK8/IKBKB/MTOR/PRKCD/PIK3R1	0.149564958901389
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/2306	149/9376	1.0096567460433	PRKACB/NDUFC2/GNAI3/NDUFB3/MAPK1/NDUFB5/ITPR1/NDUFV2/GNG5/NDUFA13/NDUFAB1/NDUFB8/NDUFA9/NDUFS4/NDUFA10/NDUFA2/NDUFA12/NDUFA6/ADCY7/GNGT2/NDUFB9/NDUFB6/NDUFA8/NDUFB4/NDUFS3/MAPK9/GNAI2/PLCB2/MAPK8/ADCY3/NDUFA7/NDUFA4/PLCB1/GNG10/PLCB3/ADCY6/GABRD	0.0678577205648274
NA	NA	hsa04981	Folate transport and metabolism	8/2306	31/9376	1.04926838821587	MTHFD1/MTHFS/SHMT2/ABCC5/DHFR/ABCC1/TYMS/SHMT1	0.156915242268559
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	33/2306	133/9376	1.00883605370756	PRKACB/GNAI3/PPP2R5A/CAMK2D/PPP3CA/PPP1CB/PPP1CC/PPP3CC/ITPR1/GNG5/PPP2R2B/PPP2R2A/ATF6B/PPP2CA/ATF2/ARRB2/GNGT2/PPP2R3C/CLOCK/CALM3/CALM1/CAMK2G/MAPK9/GNAI2/PPP2R1B/PLCB2/AKT1/GSK3B/MAPK8/PPP2R2D/PLCB1/GNG10/PLCB3	0.0586115590575068
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2306	23/9376	1.06067347939213	GLS/GLUD1/ARG2/GOT1/CAD/GPT2	0.166376864108691
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/2306	44/9376	1.01647875108413	PRKACB/RAB5A/STX4/NSF/DYNLL1/VAMP2/ARHGDIB/DCTN6/ADCY3/AQP3/ADCY6	0.0625703882259179
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/2306	36/9376	1.01647875108413	GCNT1/GALNT3/GALNT1/B4GALT5/C1GALT1C1/C1GALT1/ST6GALNAC4/GALNT2/ST3GAL2	0.0565728018983037
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	45/2306	184/9376	0.994381386930126	SRGAP3/SEMA4D/RAC2/GNAI3/CAMK2D/KRAS/ARHGEF12/PPP3CA/MAPK1/PPP3CC/CDC42/PLXNA4/MYL12A/RAF1/LIMK1/RYK/PIK3CA/RGS3/PPP3R1/SRGAP2/MYL12B/PIK3CD/ROCK1/NRAS/NCK1/CAMK2G/NFATC3/GNAI2/SSH2/GSK3B/PLXNC1/NFATC2/LRIG2/EPHA1/FYN/CFL1/CDK5/RHOA/EPHB6/EFNA5/NCK2/LRRC4/EPHB3/PARD6B/PIK3R1	-0.0439580695224017
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	16/2306	65/9376	1.00084061645206	KRAS/MAPK1/MAP2K1/ITPR1/MAP2K2/ARRB2/RAF1/PIK3CA/PIK3CD/NRAS/PLCB2/AKT1/PLCB1/GNRH1/PLCB3/PIK3R1	0.0038838458399994
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2306	28/9376	1.01647875108413	B4GALT1/B3GNT2/B4GALT4/A4GALT/ST3GAL3/B4GALT3/B3GALNT1	0.0498711680672339
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	41/2306	168/9376	0.992276876058316	SOCS1/PIM1/CCND3/STAM/IL10RA/SOS2/CCND2/SOCS4/EP300/PTPN2/BCL2/STAT4/IFNGR1/STAT1/MCL1/IL2RB/CISH/STAT3/SOCS2/OSM/RAF1/IL27RA/IRF9/JAK3/PIK3CA/PTPN6/SOS1/GRB2/IL2RA/PIK3CD/JAK2/IL4R/JAK1/STAM2/IL2RG/AKT1/MTOR/TYK2/PIAS4/SOCS7/PIK3R1	-0.0576860195541356
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	35/2306	144/9376	0.98824323022068	ID3/ID2/JARID2/KRAS/MAPK1/CTNNB1/MAP2K1/ZFHX3/SKIL/PCGF5/MAP2K2/STAT3/RAF1/SMAD4/JAK3/PIK3CA/SMARCAD1/GRB2/SMAD5/REST/PIK3CD/NRAS/SETDB1/JAK2/TCF7/JAK1/PCGF6/AKT1/GSK3B/BMPR1A/ACVR1B/TCF3/HOXA1/PIK3R1/WNT11	-0.0811945622785797
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/2306	45/9376	0.99389033439337	ABCB1/TAP1/ABCG1/TAP2/ABCD3/ABCC5/ABCC1/ABCA5/ABCC10/ABCA2/ABCD2	-0.0234620084086216
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/2306	45/9376	0.99389033439337	KLRC1/GZMB/KLRD1/HLA-F/PRF1/KIR2DL3/HLA-B/HLA-A/FASLG/FAS/KIR2DL1	-0.0234620084086216
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/2306	37/9376	0.989006352406179	UAP1/UGP2/PGM2/GALE/GMDS/PGM1/PMM2/TGDS/GMPPA	-0.038264678476206
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/2306	75/9376	0.975819601040763	MAT2A/PGK1/IDH2/IDH3A/PFKP/RPIA/PRPS1/RPE/SHMT2/MAT2B/ARG2/CS/ENO1/BCAT2/ALDOA/GOT1/SHMT1/GPT2	-0.120070095047233
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	37/2306	154/9376	0.976875682860071	PRKACB/PIK3R6/CD38/GNAI3/CAMK2D/KRAS/CAMK1/PIK3CG/PPP3CA/PPP1CB/PPP1CC/MAPK1/PPP3CC/MAP2K1/ITPR1/MAP2K2/RAF1/ADCY7/PPP3R1/PPP1R12A/CALM3/ROCK1/NRAS/CAMK4/CALM1/CAMK2G/NFATC3/PRKAG1/GNAI2/PLCB2/ADCY3/NFATC2/ELK1/PLCB1/RHOA/PLCB3/ADCY6	-0.165242707076679
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	44/2306	183/9376	0.977597050222987	XPO1/NOP10/NOP58/XRN1/RAN/POP5/NMD3/RIOK2/GNL3L/GNL3/UTP18/RIOK1/NXT1/XRN2/SBDS/UTP6/RPP30/NXF1/GTPBP4/CSNK2A1/WDR3/BMS1/CSNK2A2/EFL1/EIF6/MDN1/HEATR1/NAT10/NOB1/RPP25L/RCL1/WDR36/UTP14A/CSNK2B/POP7/RPP38/UTP15/AK6/WDR75/PWP2/POP4/REXO5/NXT2/RMRP	-0.174786426314318
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/2306	67/9376	0.970964777154988	LDHB/PGK1/ALDH3A2/PDHA1/PGM2/ADPGK/PFKP/DLD/GAPDHS/PDHB/PGM1/DLAT/ENO1/ALDOA/LDHA/MINPP1	-0.136212396078763
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/2306	42/9376	0.968075001032503	MAP1LC3B/VDAC3/VDAC2/SLC3A2/ATG5/SAT2/ACSL3/TP53/LPCAT3/GSS	-0.118420590295418
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	52/2306	217/9376	0.974320646200455	CCND3/PRKACB/PTGES3/GNAI3/KRAS/SOS2/KPNA4/KPNA2/MAPK1/BCL2/MAP2K1/NFKB1/JAG1/GSTM2/MAP2K2/STAT3/ATF6B/ATF2/RB1/ARRB2/HSP90AB1/RPS6KA3/RAF1/KPNA1/ADCY7/PIK3CA/SOS1/GRB2/NOTCH2/KPNA3/PIK3CD/RPS6KB1/NRAS/RPS6KA1/JAK2/AIP/RELA/RXRA/ARNT/RPS6KB2/GNAI2/AKT1/ADCY3/MTOR/HSP90AA1/DLL1/KPNA5/TNFSF11/FGF22/ADRB1/ADCY6/PIK3R1	-0.218572495653323
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/2306	38/9376	0.962979869448122	CD38/NNT/SIRT2/SIRT1/NT5C2/PNP/NT5C/SIRT5/SIRT3	-0.130589540051859
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	37/2306	155/9376	0.970573259099684	PRKACB/LEF1/GNAI3/CAMK2D/CDKN2C/RAP1A/MAPK1/CTNNB1/MAP2K1/ITPR1/CDKN1B/MAP2K2/ATF6B/ATF2/RB1/CDKN2A/ADCY7/BRAF/CAMK2G/AIP/RBBP5/FH/TCF7/ARNT/GNAI2/ASH2L/PLCB2/GSK3B/ADCY3/CDK2/ORAI1/CDK6/PLCB1/POMC/PLCB3/ADCY6/WNT11	-0.210971886436561
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/2306	21/9376	0.968075001032503	CHST12/CSGALNACT2/CHST11/XYLT1/CHST14	-0.0836419648030207
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/2306	17/9376	0.956685883373297	SCP2/HSD17B4/ACOT8/SLC27A5	-0.102080968407921
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/2306	69/9376	0.942820870570786	PRKACB/PTGER2/GNAI3/PPP3CA/PPP3CC/ITPR1/PPP3R1/CALM3/CALM1/GNAI2/PLCB2/ORAI1/PLCB1/ADRB1/PLCB3/ADCY6	-0.272246816454262
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2306	35/9376	0.929352000991203	PFKP/GMDS/TIGAR/PMM2/GMPPA/ALDOA/KHK/TKFC	-0.239134801832457
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/2306	78/9376	0.938288077923811	MAPK1/IFNGR1/NFKB1/STAT1/ITGAM/IRAK4/PTPN6/JAK2/MYD88/RELA/ITGA4/JAK1/IRAK1/NCF4/ELK1/TAB1/TRAF6/MAP3K7	-0.312555529369139
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	86/2306	362/9376	0.965935608765028	CCND3/MDM2/PIK3R6/RBL2/BCL2L11/PIK3AP1/PPP2R5A/ITGB7/KRAS/SOS2/EIF4E/SYK/CCND2/PIK3CG/DDIT4/MAPK1/THEM4/BCL2/MAP2K1/CDKN1B/NFKB1/MCL1/IL2RB/GNG5/MAP2K2/PPP2R2B/PPP2R2A/ATF6B/COL9A2/YWHAZ/PPP2CA/CASP9/ATF2/CSF1/OSM/HSP90AB1/PKN2/EIF4E2/RAF1/PTEN/JAK3/GNGT2/PIK3CA/SOS1/GRB2/PPP2R3C/IL2RA/AREG/PIK3CD/EIF4B/RPS6KB1/NRAS/FASLG/JAK2/RELA/RXRA/ITGA4/IL4R/RPS6KB2/JAK1/PPP2R1B/CHUK/TP53/IL2RG/AKT1/GSK3B/IKBKB/PHLPP1/CDK2/PPP2R2D/MTOR/HSP90AA1/TSC1/LPAR3/CDK6/STK11/LPAR2/YWHAB/FGF22/EFNA5/GNG10/IKBKG/BRCA1/COL9A3/KIT/PIK3R1	-0.377486759557016
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	36/2306	154/9376	0.950473637377367	PRKACB/PIK3R6/GNAI3/PPP2R5A/CAMK2D/ATP2A2/PIK3CG/PPP1CB/PPP1CC/MAPK1/BCL2/PPP2R2B/PPP2R2A/ATP1A1/ATF6B/PPP2CA/ATF2/ADCY7/ATP1B1/PPP2R3C/CALM3/RPS6KA5/CALM1/CAMK2G/GNAI2/PPP2R1B/PLCB2/AKT1/ADCY3/PPP2R2D/TPM3/PLCB1/TPM4/ADRB1/PLCB3/ADCY6	-0.35390754165424
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/2306	18/9376	0.903536667630336	ACSL3/CBR4/ACACA/MCAT	-0.23394435789667
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/2306	75/9376	0.921607400982943	PRKACB/HSPA5/ITPR1/GSR/ATP1A1/ATF6B/ATF2/ADCY7/ATP1B1/TTF2/PDIA4/PLCB2/ADCY3/PLCB1/PLCB3/ADCY6/ASGR2	-0.389265984851837
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2306	23/9376	0.883894566160112	GLS/MDH1/ATP1A1/GLUD1/ATP1B1	-0.318380587066911
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/2306	203/9376	0.941369483762641	CCND3/RAC2/ITGB7/SOS2/CCND2/RAP1A/PPP1CB/PPP1CC/MAPK1/CTNNB1/BCL2/CAPN2/MAP2K1/VASP/BIRC2/CDC42/VAV3/PARVG/COL9A2/MYL12A/RAF1/PTEN/PIK3CA/SOS1/GRB2/DIAPH1/PPP1R12A/PXN/BRAF/MYL12B/VAV1/PIK3CD/ROCK1/ACTN4/BIRC3/ITGA4/MAPK9/CRKL/AKT1/GSK3B/MAPK8/PIP5K1A/ELK1/FYN/RHOA/COL9A3/PIK3R1	-0.482304843290835
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	17/2306	76/9376	0.909480987812115	PRKACB/GNAI3/CAMK2D/ITPR1/ATP1A1/ADCY7/ATP1B1/CALM3/CALM1/CAMK2G/GNAI2/PLCB2/ADCY3/EZR/PLCB1/PLCB3/ADCY6	-0.45249179710342
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/2306	37/9376	0.879116757694381	IL18/FASLG/MYD88/PLCB2/FAS/PLCB1/THOP1/PLCB3	-0.42074828763709
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/2306	59/9376	0.895879577226689	PRKACB/GNAI3/PTGER3/ABHD5/ADCY7/PIK3CA/PIK3CD/GNAI2/AKT1/ADCY3/ADRB1/ADCY6/PIK3R1	-0.458172969360615
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/2306	98/9376	0.912756429544932	PRKACB/PRKD3/CAMK2D/CAMK1/ITPR1/ATP1A1/ATF6B/ATF2/ADCY7/ATP1B1/CALM3/CAMK4/CALM1/CAMK2G/PLCB2/ADCY3/ORAI1/PLCB1/POMC/PLCB3/ADCY6/NR4A2	-0.495820943418416
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/2306	46/9376	0.883894566160112	ALAS1/GUSB/FXN/COX10/PPOX/CPOX/MMAB/HCCS/COX15/FECH	-0.450812783181066
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/2306	38/9376	0.855982106176108	UAP1/UGP2/PGM2/GALE/GNPDA2/PGM1/PMM2/GMPPA	-0.508027125602483
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/2306	69/9376	0.883894566160112	PRKACB/CAMK2D/PPP3CA/PPP1CB/PPP1CC/PPP3CC/HDAC1/SIRT1/ATF6B/ATF2/PPP3R1/CALM3/CAMK4/CALM1/CAMK2G	-0.552812451876899
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/2306	52/9376	0.860097404763493	VAPA/APOC2/VDAC3/VDAC2/VDAC1/STARD3NL/SORT1/MYLIP/STARD3/LDLRAP1/CIDEB	-0.577739276250882
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/2306	70/9376	0.871267500929253	CASP8/CASP3/RAC2/CYCS/CD55/BID/HLA-F/PRF1/EIF4G2/CASP9/HLA-B/EIF4G3/HLA-A/SNTB1/FYN	-0.617392399790925
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	35/2306	157/9376	0.906414172941261	CCND3/LEF1/ID2/TP53BP2/MOB1A/PATJ/RASSF1/CCND2/PPP1CB/PPP1CC/CTNNB1/BIRC2/PPP2R2B/PPP2R2A/YWHAZ/PPP2CA/SMAD4/CSNK1D/AREG/LATS1/LLGL2/BIRC3/SMAD7/TCF7/PPP2R1B/MOB1B/GSK3B/PPP2R2D/BBC3/BTRC/BMPR1A/YWHAB/LIMD1/PARD6B/WNT11	-0.675341727257847
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/2306	48/9376	0.84706562590344	ATP1A1/ATP1B1/PIK3CA/PIK3CD/PLCB2/AKT1/PLCB1/PLCB3/SLC37A4/PIK3R1	-0.606648380824612
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/2306	44/9376	0.831664432705196	GZMB/HSPD1/HLA-F/PRF1/HLA-B/HLA-A/FASLG/FAS/PTPRN2	-0.639175975417872
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2306	16/9376	0.762359063313096	A4GALT/ST3GAL2/B3GALNT1	-0.543311509560925
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/2306	59/9376	0.826965763593867	ODC1/LAP3/GSR/IDH2/GSTM2/GSTK1/SMS/TXNDC12/GGCT/RRM2B/GSS/CHAC2	-0.761422281850035
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/2306	50/9376	0.813183000867303	ODC1/LAP3/CNDP2/AMD1/ALDH3A2/SMS/SAT2/OAT/ARG2/GOT1	-0.756413499643836
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/2306	82/9376	0.842933598460009	HPRT1/GMPS/GSTM2/GUSB/NME3/TPMT/UPP1/NME7/CDADC1/NME1/UMPS/DPYD/NAT1/RRM2B/IMPDH1/NME6/UCK1	-0.815820227191367
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/2306	17/9376	0.717514412529973	TXNRD1/SEPHS2/PAPSS1	-0.665750673821738
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/2306	17/9376	0.717514412529973	CA5B/GLUD1/CA13	-0.665750673821738
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2306	12/9376	0.677652500722752	GGCX/COQ5	-0.638101563373706
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/2306	12/9376	0.677652500722752	NCAM1/CD46	-0.638101563373706
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2306	32/9376	0.762359063313096	B4GALT1/UGP2/PGM2/GALE/PFKP/PGM1	-0.769016065231352
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/2306	87/9376	0.841223794000658	COX6A2/ATP2A2/UQCRC2/UQCRFS1/COX5A/ATP1A1/ATP1B1/COX7A2L/COX7B/UQCR10/COX7C/COX7A2/UQCRH/ASPH/CYC1/COX6A1/TPM3/TPM4	-0.849701036059223
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/2306	37/9376	0.769227162982584	GLS/PPAT/GLUD1/ADSL/GOT1/CAD/GPT2	-0.803231896797975
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/2306	42/9376	0.774460000826003	HADH/GCDH/ALDH3A2/ECHS1/DLST/DLD/CAT/ACAT2	-0.836603937391046
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/2306	97/9376	0.838332990584848	PRKACB/GNAI3/CAMK2D/MAPK1/ITPR1/GNG5/PER2/ADCY7/GNGT2/CALM3/RPS6KA5/CALM1/CAMK2G/GNAI2/PLCB2/ADCY3/PLCB1/GNG10/PLCB3/ADCY6	-0.914033823991294
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/2306	23/9376	0.707115652928089	B4GALT1/POMGNT1/ST3GAL3/B4GALT3	-0.803138038242514
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/2306	23/9376	0.707115652928089	LNPEP/CTSA/PREP/THOP1	-0.803138038242514
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/2306	142/9376	0.858996127676728	RAC2/SUMO1/CTNNB1/BCL2/NFKB1/SUMO2/GSTM2/HSP90AB1/PIK3CA/TXN2/CALM3/PIK3CD/CALM1/RELA/SUMO4/MAP2K6/MAP2K4/MAPK9/CHUK/TP53/AKT1/MAPK8/IKBKB/HSP90AA1/BMPR1A/PIAS4/RHOA/IKBKG/MAP3K7/PIK3R1	-0.966909571828324
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/2306	38/9376	0.748984342904095	KRAS/MAPK1/ATP1A1/ATP1B1/PIK3CA/PIK3CD/PIK3R1	-0.885464711153107
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/2306	134/9376	0.849594180010615	PRKACB/ARHGEF12/ARHGEF1/PPP1CB/PPP1CC/MAPK1/MAP2K1/ITPR1/GNA13/MAP2K2/RAF1/ADCY7/PPP1R12A/BRAF/CALM3/ROCK1/CALM1/PRKCH/PLCB2/ADCY3/PLA2G6/PLCB1/PRKCD/RHOA/PLCB3/ADCY6/ARAF/KCNMB4	-1.00147391431725
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/2306	29/9376	0.701019828333882	MOB1A/RASSF1/LATS1/MOB1B/LIMD1	-0.920896552853888
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/2306	39/9376	0.729779616162964	GZMB/HLA-F/PRF1/HLA-B/HLA-A/FASLG/FAS	-0.965722418725494
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/2306	19/9376	0.641986579632081	IDS/GUSB/HPSE	-0.89209966294089
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/2306	49/9376	0.746800715082217	PRKACB/GNAI3/NFKB1/ATF6B/ATF2/RGS9/RELA/GNAI2/CDK5	-1.01483423428909
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/2306	65/9376	0.750630462339049	PRKACB/ITPR1/ATF6B/ATF2/ADCY7/PLCB2/ADCY3/ORAI1/PLCB1/POMC/PLCB3/ADCY6	-1.15214595085313
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2306	36/9376	0.677652500722752	UGP2/PGM2/GYG1/PGM1/PYGM/GBE1	-1.10664340555454
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/2306	26/9376	0.625525385282541	LMBRD1/SLC19A2/ABCC1/PLB1	-1.09196529039991
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/2306	66/9376	0.73925727351573	IL18/STAT4/IFNGR1/GATA3/NFKB1/STAT1/STAT3/TBX21/RELA/IL4R/IL2RG/NOD2	-1.2139894498313
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/2306	86/9376	0.756449303132375	PRKACB/CAMK2D/ATP1A1/ATF6B/ATF2/ADCY7/ATP1B1/VAMP2/CAMK2G/PLCB2/ADCY3/PLCB1/PLCB3/ADCY6/KCNMB4/RAB3A	-1.29579508392002
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/2306	22/9376	0.554442955136797	CNDP2/ALDH3A2/CARNMT1	-1.1948724705543
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/2306	28/9376	0.580845000619502	GCH1/QDPR/DHFR/GPHN	-1.26852753061243
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2306	28/9376	0.580845000619502	TCIRG1/ATP6V1G1/ATP6V1D/ATP6V0E2	-1.26852753061243
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/2306	93/9376	0.743231774986244	PRKACB/CD38/ITPR1/ATP1A1/ADCY7/ATP1B1/VAMP2/CALM3/PRH1/CALM1/PLCB2/ADCY3/SLC12A2/PLCB1/ADRB1/PLCB3/ADCY6	-1.42116387910944
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	46/2306	226/9376	0.82757562035168	PRKACB/PTGER2/RAC2/RRAS2/GNAI3/CAMK2D/ATP2A2/EP300/RAP1A/PPP1CB/PPP1CC/MAPK1/PTGER3/MAP2K1/NFKB1/VAV3/MAP2K2/ATP1A1/RAF1/ADCY7/ATP1B1/PIK3CA/PPP1R12A/BRAF/VAV1/CALM3/PIK3CD/ROCK1/CAMK4/CALM1/CAMK2G/RELA/TIAM1/MAPK9/GNAI2/AKT1/MAPK8/ADCY3/ORAI1/POMC/RHOA/ADRB1/ACOX3/ADCY6/GIPR/PIK3R1	-1.49846956822876
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/2306	17/9376	0.478342941686649	CSAD/ADO	-1.22942037923556
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/2306	89/9376	0.730951012015553	PRKACB/GLS/SLC38A1/GNAI3/GNG5/GABARAPL2/ADCY7/GNGT2/NSF/SLC38A2/GNAI2/ADCY3/GNG10/ADCY6/GPHN/GABRD	-1.45644546012835
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/2306	65/9376	0.688077923810795	AGPAT5/DGKZ/AGK/ALDH3A2/LPIN1/DGKD/PLPP5/DGKE/DGKH/TKFC/GK	-1.44115340002641
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2306	29/9376	0.560815862667105	RGS9/CALM3/CALM1/GUCY2D	-1.35274241058911
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/2306	76/9376	0.695485461268088	HMGCS1/SLC27A2/SCP2/ACADM/DBI/ACSL3/RXRA/SLC27A5/FABP5/CPT1A/ACOX3/PPARD/GK	-1.52222530432522
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/2306	41/9376	0.595011951854124	ALAS1/DLD/SHMT2/SHMT1/SRR/GCAT	-1.48416626768888
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/2306	52/9376	0.625525385282541	PRKACB/ADCY7/HSD17B7/ADCY3/ACOT4/ADCY6/ACOT2/CYP2J2	-1.54642372799056
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/2306	116/9376	0.736070819750576	PRKACB/GLS/SLC38A1/GNAI3/PPP3CA/MAPK1/PPP3CC/ITPR1/GNG5/ADCY7/GRK2/GNGT2/PPP3R1/SLC38A2/GNAI2/PLCB2/ADCY3/PLCB1/GNG10/PLCB3/ADCY6	-1.63349004810887
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/2306	63/9376	0.645383334021669	GADD45A/LEF1/CTNNB1/DDB2/BAX/BAK1/TCF7/TP53/GSK3B/WNT11	-1.61283596157819
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/2306	53/9376	0.613723019522493	PRKACB/ATP1A1/ATP1B1/DNM2/PLCB2/PLCB1/PLCB3/ADCY6	-1.61051399592796
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/2306	26/9376	0.469144038961905	PLA2G6/PLB1/ACOX3	-1.54797217454339
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/2306	102/9376	0.677652500722752	CD38/ATP2A2/RAP1A/RAB8A/ITPR1/ATP1A1/RAB27B/ADCY7/ATP1B1/PLCB2/ADCY3/SLC12A2/PLCB1/RHOA/TPCN2/PLCB3/ADCY6	-1.86937499085858
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/2306	51/9376	0.55806676530109	PAFAH1B1/AGPS/LPCAT4/SELENOI/PLA2G6/CEPT1/PLB1	-1.80726947605192
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/2306	115/9376	0.671759870281685	PRKACB/CASP3/GNAI3/KRAS/MAPK1/MAP2K1/ITPR1/GNG5/RAF1/GNGT2/BRAF/NRAS/GNAI2/PLCB2/PLCB1/GNG10/PLCB3/ARAF/CYP2J2	-2.02263368839118
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2306	30/9376	0.406591500433651	PLA2G6/PLB1/CYP2J2	-1.85911855058239
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/2306	54/9376	0.527063056117696	GZMB/HLA-F/PRF1/HLA-B/HLA-A/FASLG/FAS	-1.99044945654816
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2306	16/9376	0.254119687771032	GOT1	-1.70528430008173
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/2306	24/9376	0.338826250361376	HS6ST2/XYLT1	-1.85214318152129
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/2306	61/9376	0.533234754667084	SLC30A1/TRPM7/ATP1A1/ATP1B1/ATP7A/CLCN2/SLC26A6/MT1F	-2.08870728899581
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	62/2306	323/9376	0.780454273278216	SOCS1/PIM1/MDM2/CASP3/GLS/BCL2L11/ABCB1/KRAS/SPRY2/SOS2/RASSF1/CCND2/DDIT4/EP300/MAPK1/HDAC1/ATM/BCL2/MAP2K1/CDKN1B/NFKB1/MCL1/DNMT1/SIRT1/HNRNPK/MAP2K2/PDCD4/STAT3/CCNG1/EZH2/UBE2I/RAF1/CDKN2A/PTEN/PIK3CA/MDM4/SOS1/GRB2/BAK1/NOTCH2/DNMT3A/PIK3CD/ROCK1/RPS6KA5/NRAS/CRKL/TP53/IKBKB/EZR/MTOR/HDAC5/NOTCH1/ABCC1/CDK6/SLC7A1/CD44/STMN1/RHOA/EFNA5/BRCA1/BCL2L2/PIK3R1	-2.29316641230045
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/2306	79/9376	0.566140063894958	TCIRG1/ATP6V1G1/ATP6V1D/ATP6V1H/NSF/ATP6V0E2/VAMP2/STX3/STX2/DNM2/RAB3A	-2.21155253752601
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/2306	91/9376	0.580845000619502	PRKACB/GNAI3/GNG5/ARRB2/ADCY7/GRK2/GNGT2/PDE7A/GNAI2/ADCY3/GNG10/ADCY6/GABRD	-2.29461577732676
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/2306	103/9376	0.592123544320851	PRKACB/CASP3/SERPINB9/NFKB1/RAB5A/ITGAM/PIK3CA/PIK3CD/ACTN4/RELA/PLCB2/ARG2/PLCB1/PLCB3/PIK3R1	-2.37707400092847
NA	NA	hsa04518	Integrin signaling	25/2306	154/9376	0.660051137067616	ITGAX/ARHGEF6/CCND3/RAC2/ITGB7/ICAM3/CCND2/CTNNB1/CDC42/PARVG/ITGAM/COL9A2/PIK3CA/PXN/FERMT3/PIK3CD/ACTN4/ITGA4/ITGAD/AKT1/GSK3B/MTOR/NCK2/COL9A3/PIK3R1	-2.42922072200742
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/2306	155/9376	0.655792742634921	TAP1/CALR/TUBA4A/HLA-F/SEC22B/RAB5A/ITGAM/TCIRG1/ATP6V1G1/ATP6V1D/SEC61B/HLA-B/M6PR/PIKFYVE/ATP6V1H/ATP6V0E2/TAP2/HLA-A/CORO1A/STX18/NCF4/TUBA1B/SEC61A2/SEC61G/RILP	-2.46775729114757
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	33/2306	195/9376	0.688077923810795	RAC2/CASP1/SYK/CASP4/VDAC3/MAPK1/VDAC2/HDAC1/MAP2K1/NFKB1/MAP2K2/HAT1/ITGAM/VDAC1/RAF1/PIK3CA/HDAC3/SLC25A5/HMGB1/PIK3CD/HDAC8/RELA/PLCB2/AKT1/MTOR/NCF4/HDAC5/HDAC10/PLCB1/PLCB3/MAP3K7/HDAC6/PIK3R1	-2.51376113674946
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/2306	100/9376	0.569228100607112	XCL1/CCR1/IL18/XCL2/IL10RA/IL2RB/CSF1/TNFSF14/CXCR3/CCL28/IL2RA/TNFRSF10A/IL2RG/TNFRSF10B	-2.47327596988762
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/2306	100/9376	0.569228100607112	CD38/CD2/CD3E/CD55/ITGAM/CSF1/CD37/CD7/IL2RA/ITGA4/IL4R/CD44/CD8A/KIT	-2.47327596988762
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/2306	36/9376	0.338826250361376	GUSB/UGP2/RPE	-2.26985961300738
Cellular Processes	Cell motility	hsa04814	Motor proteins	32/2306	194/9376	0.670666392467879	KIF2A/MYO1E/CAPZA1/DYNLT1/DYNLT3/TUBA4A/CAPZA2/HOOK3/MYL12A/ACTR10/DYNLL1/MYL12B/KIF18A/TUBE1/STARD9/KIF13B/KIF3A/DCTN6/CENPE/KIF21B/TUBA1B/MYO7A/MYO1D/TPM3/TPM4/KIFC1/MYO19/BICDL1/KIF9/DNAL4/KIF26B/KIF1A	-2.64712137555538
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/2306	63/9376	0.451768333815168	PTGES3/PTGIS/LTC4S/LTA4H/PLA2G6/PLB1/CYP2J2	-2.49341847501565
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/2306	31/9376	0.262317097053969	ALDH3A2/GUSB	-2.34945155757814
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/2306	191/9376	0.638625393351285	PRKACB/GNAI3/KRAS/SOS2/PPP1CB/PPP1CC/MAPK1/HDAC1/MAP2K1/GNG5/HAT1/ATF6B/ATF2/RAF1/GNGT2/SOS1/HDAC3/GRB2/BRAF/CALM3/NRAS/CAMK4/HDAC8/CALM1/GNAI2/HDAC5/HDAC10/GNG10/ARAF/HDAC6	-2.88164394190063
NA	NA	hsa03272	Virion - Hepatitis viruses	4/2306	48/9376	0.338826250361376	PDCD6IP/IST1/CHMP4A/CHMP7	-2.6226934724875
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/2306	50/9376	0.325273200346921	IL18/KLRB1/MYD88/KLRK1	-2.73193800456322
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/2306	90/9376	0.451768333815168	PRKACB/ABCB1/ATP1A1/ADCY7/ATP1B1/HMGCR/RXRA/ADCY3/SLC27A5/ADCY6	-2.98453457796817
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/2306	37/9376	0.219779189423595	FAH/GOT1	-2.7156499426024
Human Diseases	Immune disease	hsa05310	Asthma	1/2306	32/9376	0.127059843885516	FCER1G	-2.82487105713633
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/2306	50/9376	0.243954900260191	ITGB7/CCL28/ITGA4	-3.06119208871646
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/2306	254/9376	0.624294036098914	PRKACB/CYSLTR1/CD38/CAMK2D/CAMK1/ATP2A2/PPP3CA/VDAC3/VDAC2/PPP3CC/PTGER3/ITPR1/STIM1/VDAC1/PTK2B/ADCY7/ORAI3/ORAI2/PHKG2/PPP3R1/SLC25A5/CALM3/CAMK4/STIM2/CALM1/ASPH/CAMK2G/NFATC3/PLCB2/ADCY3/ORAI1/PTGER1/NFATC2/SPHK2/PLCB1/TPCN2/FGF22/ADRB1/PLCB3	-3.46677372369787
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/2306	86/9376	0.378224651566187	PRKACB/PLCB2/P2RY1/PLCB1/PLCB3/TAS2R30/ADCY6/TAS2R14	-3.30811387594223
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/2306	105/9376	0.425953000454301	PRKACB/ITGB7/ATP2A2/ADCY7/ITGA4/SNTB1/ADCY3/TPM3/TPM4/ADRB1/ADCY6	-3.37819249745408
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/2306	86/9376	0.330946570120414	LEF1/ITGB7/ATP2A2/CTNNB1/TCF7/ITGA4/SNTB1	-3.55965372494501
NA	NA	hsa04519	Cadherin signaling	66/2306	404/9376	0.664233639322302	LEF1/RAC2/RRAS2/KRT81/ARPC5L/ACTR3/MYO1E/KRAS/MOB1A/CSNK1A1/EP300/EVL/ACTR2/SHOC2/PPP1CB/PPP1CC/MAPK1/CTNNB1/TMC8/MAP2K3/MAP2K1/VASP/CDC42/ARPC1B/NFKB1/VAV3/MAP2K2/KRT86/ARPC3/TMC6/PTK2B/YWHAZ/ADAM10/RAF1/RYK/ABI2/CYFIP2/NCKAP1L/VAV1/LATS1/ROCK1/BRK1/NRAS/ACTN4/RELA/TCF7/MAPK9/CHUK/MOB1B/GSK3B/MAPK8/IKBKB/ARPC5/MYO7A/MRAS/MYO1D/ARPC2/RHOA/PSEN2/YWHAB/IKBKG/LIMD1/WASF1/ACTR3C/GABRD/WNT11	-3.93993281657081
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/2306	95/9376	0.342392842470443	IL18/TCIRG1/ATP6V1G1/CSF1/ATP6V1D/ATP6V1H/ATP6V0E2/TNFSF11	-3.67905711982533
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2306	41/9376	0.099168658642354	GABRD	-3.30129122536072
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/2306	68/9376	0.239171470843324	CYP26A1/RDH11/DHRS4L2/DHRS4	-3.59599137174492
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/2306	103/9376	0.355274126592511	SLC1A5/SLC3A2/ATP1A1/COL9A2/ATP1B1/COL24A1/SLC38A2/SLC36A4/COL9A3	-3.75741499678132
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/2306	160/9376	0.457415437987858	NCAM1/CD2/ITGB7/ICAM3/CD58/PTPRC/HLA-F/SPN/ITGAM/HLA-B/HLA-A/ITGA4/CD226/CD99/NECTIN3/NECTIN1/CD8A/LRRC4	-3.95331821818024
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/2306	43/9376	0.0945561628915468	ACAT2	-3.39852676631555
NA	NA	hsa04081	Hormone signaling	28/2306	219/9376	0.51984301425307	PRKACB/GNAI3/GNA13/GNG5/STAT3/SMAD4/ADCY7/GNGT2/PIK3CA/SMAD5/APPL1/PIK3CD/JAK2/GNAI2/PLCB2/ADCY3/STK11/BMPR1A/PLCB1/POMC/RHOA/GNG10/GNRH1/ADRB1/PLCB3/ADCY6/GIPR/PIK3R1	-4.10614503155222
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/2306	89/9376	0.274106629505832	CD47/ITGB7/COL9A2/ITGA4/CD44/COL9A3	-3.92948552571627
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/2306	66/9376	0.184814318378932	HSD17B11/HSD17B7/SRD5A1	-3.79541485388746
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/2306	99/9376	0.287488939700562	ITGB7/ATP2A2/PRKAG1/ITGA4/SNTB1/TPM3/TPM4	-4.0701555968036
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/2306	70/9376	0.174253500185851	GSTM2/GSTK1/NAT1	-3.96022462718633
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/2306	79/9376	0.154401835607716	GSTM2/GSTK1/AKR7A2	-4.31034214170059
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/2306	88/9376	0.184814318378932	ITGAX/CD55/ITGAM/CD46	-4.38775488458792
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/2306	233/9376	0.453707253702787	ITGB7/TMOD3/CAPZA1/CAPZA2/SPTAN1/LBR/ATP1A1/COL9A2/FMNL3/ATP1B1/COL24A1/DIAPH1/LMNB1/TMEM43/FMNL1/ITGA4/SNTB1/AMPD2/AMPD3/ENO1/TPM3/ANK2/TPM4/LMOD3/SYNE3/COL9A3	-4.8224153984111
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/2306	73/9376	0.111394931625658	GSTM2/GSTK1	-4.35275565462686
NA	NA	hsa04082	Neuroactive ligand signaling	18/2306	199/9376	0.367771206422398	PRKACB/GNAI3/GNG5/ADCY7/OGFR/GNGT2/OGFRL1/GNAI2/PLCB2/ADCY3/P2RY1/PLCB1/POMC/GNG10/ADRB1/PLCB3/ADCY6/GABRD	-5.14820730082528
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/2306	298/9376	0.409320302449985	XCL1/CCR1/TNFRSF18/IL18/XCL2/IL10RA/IFNGR1/TNFRSF4/IL2RB/CSF1/OSM/IL27RA/TNFSF14/IL16/CXCR3/CCL28/IL2RA/FASLG/RELT/TNFRSF10A/IL4R/IL2RG/GDF11/FAS/TNFRSF10B/TNFSF11/TNFSF4/BMPR1A/ACVR1B/IL32	-5.91794152300013
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/2306	143/9376	0.170597832349784	SSB/SNRPD3/SNRPD1/SNRPB/ACTN4/TRIM21	-5.70778163527775
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/2306	99/9376	0.0410698485286517	ITGAM	-5.47780257799026
NA	NA	hsa04382	Cornified envelope formation	14/2306	217/9376	0.262317097053969	KRT81/PPP2R5A/UGCG/KRT86/PPP2R2B/ABHD5/PPP2R2A/PPP2CA/SPTLC1/PPP2R3C/BLMH/PPP2R1B/PPP2R2D/GBA2	-6.27886489497868
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	27/2306	370/9376	0.296701905721854	PTGER2/CYSLTR1/GZMA/PTGER3/PTGDR/OGFR/NR3C1/S1PR4/PAQR6/OGFRL1/P2RY1/P2RY10/NMUR1/PTGER1/LPAR3/LPAR2/CHRNB1/POMC/CHRNA5/GNRH1/ADRB1/RLN2/GIPR/CNR2/TMEM97/RLN1/GABRD	-7.88278922197467
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/2306	449/9376	0.108665879848637	PRKACB/NCALD/CAMK2D/ARRB2/GRK2/CALM3/CALM1/CAMK2G/OR2A25/ADCY3/GUCY2D/OR11G2	-11.053925098492