category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	95/2085	187/9376	2.28451249695431	IL18/TANK/RIPK2/NAMPT/CXCL8/IL6/TBK1/CASP1/GBP1/TNF/NAIP/HSP90AA1/TNFAIP3/IL1B/TRPM7/TRPM2/TLR4/NLRP3/CCL2/PRKCD/AIM2/GBP5/OAS2/IRF7/BIRC2/CASP4/CHUK/CARD8/CASP8/TAB2/GBP2/NFKBIA/ATG5/MEFV/TRAF3/MYD88/STAT2/OAS1/CTSB/HSP90AB1/IFI16/MAPK13/DNM1L/BCL2L1/GBP4/ERBIN/P2RX7/MAP3K7/CXCL1/ITPR2/SUGT1/TRAF6/NEK7/IKBKE/TXN/CARD6/RIPK1/NFKB1/MAPK1/IRAK4/IRF9/XIAP/JUN/VDAC1/NLRC4/TAB3/VDAC2/RNASEL/MAPK9/IKBKB/TP53BP1/MAP1LC3B/MCU/CXCL3/PKN2/PLCB2/CARD16/NOD2/GBP3/ITPR1/BCL2/CASP5/TICAM1/NOD1/PSTPIP1/MFN1/TXNIP/CYBB/RIPK3/MAPK8/ATG16L1/CXCL2/PLCB3/BIRC3/NLRP1	9.48790068598407
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	104/2085	216/9376	2.16516564526157	SOD2/HSPA1B/IL18/TANK/HSPA5/HSPA1A/VAV3/CXCL8/IL6/TBK1/CASP1/ABCG1/HSPD1/CCL3L1/TNF/TLR2/ABCA1/PPARG/CCL3/DDIT3/XBP1/HSP90AA1/IL1B/HSPA6/TLR4/NLRP3/CCL2/CASP7/HSPA8/HSPA4/ICAM1/NRAS/IRAK1/CAMK2D/IRF7/CHUK/CD40/CASP8/TAB2/MAP2K3/TNFRSF10B/PPP3R1/LY96/KRAS/NFKBIA/TRAF3/MYD88/BID/RAP1A/TNFRSF10A/CYCS/STAT3/HSP90AB1/MAPK13/EIF2S1/BCL2L1/CASP3/ERO1A/MAP3K7/CXCL1/TLR6/PIK3CB/TRAF6/VAV1/IKBKE/ERN1/NCF2/JAK2/FAS/NCF4/TNFRSF1A/NCF1/NFKB1/PPP3CC/EIF2AK3/CDC42/MAPK1/HSP90B1/BAX/AKT1/IRAK4/LYN/JUN/OLR1/GSK3B/MAPK9/IKBKB/PRKCA/CXCL3/PLCB2/PIK3CA/FOS/NFATC1/ITPR1/CASP9/BCL2/TICAM1/RAP1B/CYBB/MAPK8/CXCL2/PLCB3/LDLR/TICAM2	9.26428546060773
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	109/2085	248/9376	1.97645238647791	IL18/RIPK2/CXCL8/IL6/CASP1/TNF/NAIP/TLR2/MLKL/ARL8B/HSP90AA1/M6PR/ARL8A/IL1B/CYTH1/TLR4/NLRP3/CASP7/IRAK1/ACTR3/BIRC2/ABI1/CASP4/CHUK/DYNLT3/RHOB/CASP8/TAB2/DNM2/MAP2K3/DYNLT1/RAF1/SNX18/TNFRSF10B/LY96/NFKBIA/ACBD3/MYD88/EXOC5/PLEKHM1/PLEKHM2/TNFRSF10A/CYCS/HSP90AB1/RAB5A/MAPK13/DCTN4/ARF6/CASP3/MAP2K1/PIK3C3/MAP3K7/ELMO2/TLR6/PIK3CB/TRAF6/KPNA4/TUBB2A/RAB7A/ACTR10/RAB5B/ACTR2/PIK3CG/TXN/RIPK1/TNFRSF1A/EXOC4/NFKB1/CTNNB1/CDC42/ELMO1/CYTH4/MAPK1/ARPC1A/HSP90B1/BAX/AKT1/IRAK4/JUN/VPS39/RAB9A/NLRC4/TAB3/VPS33A/CYFIP1/MAPK9/IKBKB/EXOC2/ARPC1B/PIK3CA/FOS/ARF1/BCL2/CASP5/ARPC3/MYL12A/TUBA1B/FBXO22/NOD1/MYC/RIPK3/MAPK8/SKP1/RHOH/TCF7/BIRC3/PTPRC/DYNLL1/TUBB1	8.33363000130218
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	81/2085	174/9376	2.09337633341603	HSPA1B/HSPH1/HSPA5/HSPA1A/DNAJB11/UBE2D1/HYOU1/CALR/DNAJA1/DDIT3/XBP1/HSP90AA1/HERPUD1/HSPA6/PDIA4/SEC23B/ERO1B/SEC24A/DNAJB1/HSPA8/EDEM1/SYVN1/UBE2J1/EDEM3/MAN1A1/RAD23B/SEC24D/HSP90AB1/UBE2G1/UBQLN2/EIF2S1/OSTC/UBQLN1/CUL1/UFD1/STT3B/EDEM2/RPN1/ERO1A/DERL2/MBTPS1/DNAJA2/NGLY1/UBE2G2/UBE2D3/DNAJC3/SEL1L/ERN1/PPP1R15A/DNAJC10/ATF6B/TRAM1/SEC61B/SEC23A/SAR1B/UGGT1/EIF2AK3/HSP90B1/BAX/RAD23A/NSFL1C/FBXO6/CANX/NPLOC4/UBE4B/MAPK9/SEC24C/UGGT2/PDIA3/PDIA6/SEC24B/YOD1/OS9/BCL2/UBE2D4/MAN1C1/MAPK8/HSPA4L/SKP1/BAG2/UBXN8	7.78481502199233
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	62/2085	119/9376	2.34291356830502	ADAM17/IL6/CCL20/TNF/MAP3K8/MLKL/TNFAIP3/IL1B/CEBPB/CCL2/CASP7/ATF2/ICAM1/TRAF1/BIRC2/CHUK/SOCS3/CASP8/TAB2/MAP2K3/CYLD/PTGS2/NFKBIA/TRAF3/MAPK13/DNM1L/CASP3/MAP2K1/MAP3K7/CASP10/CXCL1/IRF1/PIK3CB/BAG4/FAS/RIPK1/TNFRSF1A/ATF6B/CSF1/NFKB1/MAPK1/AKT1/XIAP/JUN/PGAM5/TAB3/MAPK9/CXCL10/IKBKB/CXCL3/PIK3CA/NOD2/FOS/MMP14/CREB5/LIF/RIPK3/MAPK8/CXCL2/JAG1/BIRC3/CFLAR	7.88372613551016
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	77/2085	163/9376	2.12429418428447	CXCL8/IL6/TBK1/TNF/TLR2/RB1/TLR4/ATF2/NRAS/IRAK1/IRF7/CHUK/CASP8/TAB2/MAP3K1/MAP2K3/GRB2/RAF1/KRAS/NFKBIA/TRAF3/MYD88/BID/DDX3X/STAT2/JAK3/CYCS/STAT3/MAPK13/CASP3/MAP2K1/SMAD4/PCNA/MAP3K7/CASP10/PIK3CB/TRAF6/STAT6/IKBKE/SOS2/E2F3/TGFBR2/JAK2/FAS/EGR2/ATF6B/STAT5A/SOS1/NFKB1/MAPK1/BAX/BRAF/AKT1/IFIH1/IRAK4/JUN/PTK2B/TLR3/MAPK9/IKBKB/PRKCA/PRKCB/EGR3/PIK3CA/FOS/NFATC1/CASP9/CDKN1A/BCL2/TICAM1/ELK1/CREB5/MYC/MAPK8/TGFB2/TICAM2/CDK2	7.7431620711536
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	105/2085	250/9376	1.88869064748201	SLC11A1/SLC11A2/CTSL/LAMTOR3/SLC36A4/SLC2A6/ATP6V1C1/ARL8B/M6PR/ARL8A/BLOC1S2/LAMP1/MCOLN2/CTBS/DMXL2/OSTM1/NPC1/DMXL1/GGA2/VPS13C/AP1G1/GGA1/VPS26A/IGF2R/SPG11/ATP6V1H/AP1S2/ATP6V1B2/CD164/MANBA/PLEKHM1/SCARB2/GLA/RRAGC/CTSB/CTSC/ZFYVE26/DTNBP1/SLC15A4/CTSS/OSBPL3/OSBP/ATP6V1A/ATP6V0A1/FUCA1/ATP6V1D/NEU1/GALC/ARSB/AP3M1/AP5M1/ABCA5/AP5B1/VAMP7/SLC36A1/VPS29/GALNS/RAB7A/GNPTAB/MCOLN1/BLOC1S6/PIKFYVE/HEXA/AP3S1/RRAGD/LGMN/AP4S1/BLOC1S5/CLN8/MCOLN3/LAPTM5/VPS39/MFSD8/MITF/ENTPD4/SORT1/MAN2B1/TLR3/SLC38A9/CTNS/VPS33A/VPS13A/ASAH1/LIPA/ATP6V1G1/NAGPA/SNAPIN/LAMP2/LITAF/AKT1S1/MTOR/ARSG/AP4B1/RRAGB/TLR8/RPTOR/CLN3/AP1G2/ATP6V1E2/ATP6V0D2/AP3S2/CLTA/CLN6/HEXB/AP1S3	7.61597483844393
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	81/2085	181/9376	2.0124170277038	IL18/RIPK2/IL6/HSPD1/FCGR2A/TNF/TLR2/TLR1/IRAK2/IFNGR1/IL1B/PLK3/IFNGR2/LAMP1/TLR4/HSPA9/FCGR2B/HLA-DQB1/CLEC4E/CEBPB/IL1A/BCL10/IRAK1/CLEC7A/CAMK2D/FCGR1A/CASP8/CEBPG/IL10RA/IL10/RAF1/FCGR3A/PPP3R1/ATP6V1H/MYD88/BID/CR1/ITGAX/CYCS/RAB5A/MAPK13/CTSS/IL10RB/ATP6V0A1/CASP3/PIK3C3/CASP10/RFX5/TLR6/TRAF6/RAB7A/RAB5B/JAK2/ARHGEF12/TNFRSF1A/NFKB1/PPP3CC/MAPK1/NFYB/BAX/AKT1/IRAK4/NFYA/HLA-DQA1/NFYC/ITGAM/MAPK9/VDR/FCER1G/LAMP2/NOD2/CASP9/BCL2/IL23A/CD209/MAPK8/ATP6V0D2/TGFB2/MRC1/FCGR3B/CYP27B1	7.35475110649999
Human Diseases	Infectious disease: viral	hsa05162	Measles	66/2085	136/9376	2.18231062209056	HSPA1B/HSPA1A/IL6/TBK1/IL2RA/TLR2/TNFAIP3/IL1B/HSPA6/TLR4/FCGR2B/HSPA8/MX1/IL1A/IRAK1/OAS2/IRF7/CHUK/CASP8/TAB2/CCND1/NFKBIA/TRAF3/MYD88/BID/STAT2/OAS1/JAK3/CYCS/STAT3/EIF2S1/BCL2L1/CASP3/MAP3K7/PIK3CB/TRAF6/IKBKE/FAS/STAT5A/NFKB1/CDKN1B/ADAR/BAX/AKT1/IFIH1/IRAK4/IRF9/JUN/GSK3B/RAB9A/CSNK2A1/MAPK9/RCHY1/IKBKB/BBC3/EIF2AK2/PIK3CA/FOS/MX2/CASP9/BCL2/CD209/MSN/MAPK8/SLAMF1/CDK2	7.42694450270804
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	77/2085	169/9376	2.04887545584834	VMP1/TANK/DAPK1/TBK1/CTSL/C9orf72/RAB8A/LAMP1/HIF1A/STX7/PRKCD/NRAS/PTEN/WDFY3/EPG5/ATG4C/RAF1/MTMR4/KRAS/ATG5/MTMR3/NRBF2/PLEKHM1/RRAGC/CTSB/RAB1A/SUPT20H/EIF2S1/BCL2L1/MAP2K1/PIK3C3/MAP3K7/PIK3CB/RHEB/TRAF6/PPP2CA/SMCR8/TP53INP2/CALCOCO2/ERN1/BIRC6/RAB7A/PPP2CB/EIF2AK3/ATG7/MAPK1/RRAGD/WIPI1/AKT1/SH3GLB1/VPS39/PRKAA1/ULK2/ATG2B/VPS33A/MAPK9/ATG3/MAP1LC3B/TSC1/DDIT4/LAMP2/PIK3CA/AKT1S1/ITPR1/BCL2/MTOR/RPS6KB1/RRAGB/ZFYVE1/RPTOR/SQSTM1/MAPK8/ATG16L1/ATG16L2/RAB33B/CFLAR/DAPK2	7.35789053277633
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	55/2085	105/9376	2.35550987781204	PLAU/BCL2A1/CXCL8/TNF/TNFAIP3/IL1B/TLR4/TRIM25/ICAM1/BCL10/IRAK1/TRAF1/BIRC2/CCL4L2/CHUK/CD40/TAB2/CYLD/LY96/PTGS2/NFKBIA/TRAF3/MYD88/BTK/BCL2L1/MAP3K7/CXCL1/TRAF6/BLNK/ATM/ERC1/RIPK1/TNFRSF1A/GADD45A/NFKB1/NFKB2/IRAK4/LYN/XIAP/UBE2I/CSNK2A1/CCL4/TAB3/IKBKB/CXCL3/PIAS4/PRKCB/TNFSF13B/BCL2/TICAM1/CXCL12/CXCL2/BIRC3/TICAM2/CFLAR	7.46928729816121
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	36/2085	56/9376	2.89085303186023	HSPA1B/IL18/HSPA1A/CXCL8/IL6/CASP1/HSPD1/SEC22B/TNF/NAIP/TLR2/IL1B/HSPA6/TLR4/CASP7/HSPA8/CASP8/CLK1/NFKBIA/MYD88/CR1/CYCS/RAB1A/CASP3/BCL2L13/CXCL1/SAR1B/NFKB1/NFKB2/CLK4/NLRC4/ITGAM/CXCL3/ARF1/CASP9/CXCL2	7.58907684353385
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	78/2085	180/9376	1.94864908073541	IL6/TBK1/SRSF7/TNF/TLR2/CALR/IFNGR1/IL1B/IFNGR2/CGAS/HLA-DQB1/SRSF1/CCL2/ZC3HAV1/SRSF6/NXF1/IRAK1/OAS2/IRF7/BIRC2/HLA-F/CHUK/SOCS3/SRSF5/CASP8/TAB2/SRSF2/NFKBIA/SRSF3/TRAF3/MYD88/BID/TAP1/STAT2/OAS1/CYCS/EIF2S1/BCL2L1/CASP3/MAP3K7/PPP1CC/PIK3CB/RHEB/SRSF9/TRAF6/IKBKE/PPP1CB/JAK2/PILRA/FAS/TNFRSF1A/NFKB1/BAX/AKT1/IFIH1/IRAK4/IRF9/TNFRSF14/SP100/HLA-DQA1/TLR3/RNASEL/IKBKB/TSC1/PDIA3/EIF2B2/TAP2/ALYREF/PILRB/SRPK1/EIF2AK2/PIK3CA/CASP9/BCL2/TICAM1/MTOR/BST2/BIRC3	6.87206850564453
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	91/2085	227/9376	1.80271500860985	CXCL8/IL6/PTGER4/TBK1/CCL3L1/TNF/CALR/CCL3/RB1/IL1B/CGAS/ARHGEF11/CCL2/ATF2/NRAS/CCR1/HLA-F/CCL4L2/CHUK/ITGAV/CASP8/ADCY7/MDM2/GRB2/IL10RA/CCND1/RAF1/GNAI3/PPP3R1/KRAS/PTGS2/NFKBIA/BID/GNB4/TAP1/GNG10/SP1/CYCS/STAT3/MAPK13/IL10RB/CASP3/MAP2K1/ITPR2/PIK3CB/RHEB/SOS2/E2F3/FAS/ARHGEF12/RIPK1/TNFRSF1A/ATF6B/SOS1/NFKB1/PPP3CC/CTNNB1/MAPK1/BAX/AKT1/CCR5/PTK2B/GSK3B/CCL4/IKBKB/PRKCA/TSC1/PDIA3/PLCB2/ADCY3/TAP2/GNA13/PRKCB/PIK3CA/GNGT2/PTGER2/NFATC1/ITPR1/CASP9/CDKN1A/CDKN2A/MTOR/CXCL12/RPS6KB1/IL6R/ELK1/GNG5/GNAQ/CREB5/MYC/PLCB3	6.54685340915759
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	74/2085	173/9376	1.92352199165523	IL18/CXCL8/IL6/TBK1/CASP1/TNF/IFNGR1/IL1B/IFNGR2/TLR4/NLRP3/HLA-DQB1/TRIM25/CCL2/DNAJB1/RSAD2/MX1/ICAM1/NXF1/IL1A/OAS2/PABPN1/IRF7/CHUK/SOCS3/CASP8/RAF1/TNFRSF10B/NFKBIA/TRAF3/NUP98/MYD88/BID/XPO1/STAT2/OAS1/TNFRSF10A/CYCS/EIF2S1/CASP3/MAP2K1/PIK3CB/IKBKE/DNAJC3/CALCOCO2/NXT2/JAK2/FAS/TNFRSF1A/NFKB1/ADAR/MAPK1/BAX/AKT1/IFIH1/IRAK4/IRF9/VDAC1/HLA-DQA1/SLC25A5/TLR3/RNASEL/CXCL10/IKBKB/PRKCA/KPNA2/PRKCB/EIF2AK2/PIK3CA/MX2/NXT1/CASP9/TICAM1/KPNA5	6.55617746894744
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	64/2085	142/9376	2.02676394095991	UBE2D1/HERC4/UBE2A/SMURF2/SIAH1/NEDD4L/UBA6/UBE2F/UBE2W/BIRC2/SOCS3/UBE2N/SYVN1/MAP3K1/PIAS1/MDM2/UBE2J1/VHL/KLHL9/SOCS1/CUL2/UBE2B/UBE2G1/CUL1/UBE2Z/UBE2E1/TRIP12/UBE3A/UBE2G2/TRAF6/HERC2/UBE2D3/CDC27/BIRC6/CDC26/PIAS2/ANAPC10/ANAPC7/CUL3/ELOC/CUL4A/UBE2E2/CUL5/XIAP/UBA3/PPIL2/COP1/UBE2I/BTRC/UBR5/UBE4B/RCHY1/PIAS4/ANAPC4/UBE2D4/UBE3B/ERCC8/FANCL/UBE2O/SKP1/SMURF1/ANAPC1/BIRC3/PIAS3	6.59272505314586
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	52/2085	108/9376	2.16516564526157	DDX39B/NUP58/ACIN1/TMEM33/NXF1/NUP98/EIF4A3/NUP62/XPO1/IPO7/THOC1/NUP54/RNPS1/SUMO1/TNPO1/KPNA4/NUP153/NXT2/PYM1/AHCTF1/THOC3/POM121C/NUP205/TNPO3/NMD3/MAGOH/XPO4/UBE2I/SEH1L/NUP160/SUMO4/NUP107/KPNA2/ALYREF/PNN/DDX19B/NCBP1/RANBP2/NUP133/NXT1/DDX19A/XPOT/THOC6/NUP93/SENP2/NUP88/KPNA5/NUP43/IPO11/SUMO2/NUP35/NUP188	6.51255876270421
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	80/2085	196/9376	1.83546224245094	CXCL8/IL6/TBK1/IFNGR1/ZFP36/RB1/HIF1A/ICAM1/NRAS/CCR1/IRF7/HLA-F/PREX1/CHUK/CASP8/HCK/CCND1/RAF1/PPP3R1/KRAS/PTGS2/NFKBIA/PDGFB/TRAF3/BID/GNB4/STAT2/GNG10/CYCS/STAT3/MAPK13/CASP3/MAP2K1/PIK3C3/CXCL1/ITPR2/MICB/PIK3CB/IKBKE/E2F3/JAK2/PIK3CG/FAS/TNFRSF1A/NFKB1/PPP3CC/CTNNB1/MAPK1/BAX/AKT1/IRF9/LYN/JUN/CCR5/RCAN1/GSK3B/TLR3/MAPK9/IKBKB/ATG3/CD200R1/MAP1LC3B/CXCL3/CLEC2B/EIF2AK2/PIK3CA/GNGT2/FOS/NFATC1/ITPR1/CASP9/CDKN1A/TICAM1/MTOR/GNG5/MYC/MAPK8/CXCL2/MICA/TCF7	6.32089594721997
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	63/2085	142/9376	1.99509575438241	ATP2A2/FCGR2A/TNF/PPARG/LCP2/IFNGR1/IL1B/LILRB1/IFNGR2/FCGR2B/IL1A/SIRPA/CHUK/SOCS3/OSCAR/FCGR1A/TAB2/GRB2/FCGR3A/CYLD/PPP3R1/NFKBIA/STAT2/BTK/LILRB4/SOCS1/LILRA5/MAPK13/LILRA1/MAP2K1/MAP3K7/ITPR2/PIK3CB/TRAF6/BLNK/NCF2/TGFBR2/NCF4/TNFRSF1A/CSF1/NCF1/NFKB1/PPP3CC/NFKB2/MAPK1/AKT1/IRF9/JUN/MITF/MAPK9/IKBKB/PIK3CA/LILRB5/FOS/NFATC1/ITPR1/TEC1/FOSL1/SQSTM1/JUND/MAPK8/TGFB2/FCGR3B	6.38938751984489
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	85/2085	214/9376	1.78614491584303	TBK1/TNF/TLR2/CALR/CGAS/TLR4/NRAS/IRAK1/APOBEC3G/HLA-F/CHUK/CASP8/TAB2/AP1G1/MAP2K3/RAF1/GNAI3/PPP3R1/KRAS/NFKBIA/AP1S2/MYD88/BID/GNB4/TAP1/GNG10/LIMK2/TRIM5/CYCS/MAPK13/BCL2L1/CUL1/CASP3/MAP2K1/APOBEC3A/MAP3K7/ATR/ITPR2/PIK3CB/TRAF6/ATM/FAS/RIPK1/TNFRSF1A/NFKB1/PPP3CC/ELOC/MAPK1/BAX/AKT1/IRAK4/CUL4A/CUL5/JUN/CCR5/PTK2B/DCAF1/BTRC/MAPK9/IKBKB/PRKCA/LIMK1/PDIA3/TAP2/PRKCB/PIK3CA/GNGT2/FOS/NFATC1/ITPR1/CASP9/BCL2/MTOR/RPS6KB1/APOBEC3F/GNG5/GNAQ/AP1G2/MAPK8/SKP1/BST2/APOBEC3H/WEE1/CHEK1/AP1S3	6.22098954960949
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	88/2085	224/9376	1.76663240835903	IL6/IL2RA/TNF/CALR/ZFP36/RB1/IL15RA/HLA-DQB1/ATF2/ICAM1/NRAS/HLA-F/PTEN/CHUK/CD40/MAP3K1/ADCY7/CCND1/PPP3R1/KRAS/NFKBIA/XPO1/JAK3/BCL2L1/MAP2K1/ELK4/SMAD4/ATR/PIK3CB/POLB/VAC14/CDC27/ATM/E2F3/TGFBR2/EGR2/NRP1/TNFRSF1A/CDC26/ATF6B/ANAPC10/STAT5A/ANAPC7/NFKB1/PPP3CC/NFKB2/MAPK1/NFYB/BAX/SMAD2/GPS2/AKT1/XIAP/CDKN2B/JUN/VDAC1/EGR1/HLA-DQA1/SLC25A5/CANX/BUB3/ETS2/VDAC2/DLG1/MAPK9/IKBKB/RANBP1/TBP/ADCY3/CRTC2/KAT2B/TBPL1/PIK3CA/FOS/ANAPC4/NFATC1/CDKN1A/CDKN2A/ELK1/FOSL1/CREB5/KAT2A/MYC/MAPK8/TGFB2/ANAPC1/CHEK1/CDK2	6.2100957547427
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	67/2085	156/9376	1.93135337883539	TBK1/TNF/IFIT1/RB1/NR1H3/RSAD2/MX1/NRAS/OAS2/IRF7/CHUK/SOCS3/CASP8/PIAS1/GRB2/CCND1/PPP2R2A/RAF1/KRAS/NFKBIA/TRAF3/BID/STAT2/OAS1/CYCS/STAT3/EIF2S1/CASP3/MAP2K1/YWHAG/PIK3CB/TRAF6/PPP2CA/IKBKE/SOS2/E2F3/PPP2CB/FAS/RIPK1/TNFRSF1A/SOS1/NFKB1/CTNNB1/MAPK1/BAX/BRAF/AKT1/PPP2R2D/IRF9/GSK3B/TLR3/RNASEL/CXCL10/IKBKB/YWHAH/EIF2AK2/CLDN23/PIK3CA/MX2/CASP9/CDKN1A/TICAM1/MYC/OCLN/LDLR/CDK2/CFLAR	6.2727279411707
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	44/2085	87/9376	2.27428539926679	PMAIP1/NRAS/GRB2/CCND1/RAF1/POLK/KRAS/CYCS/CASP3/MAP2K1/SMAD4/PIK3CB/RALB/SOS2/MLH1/MSH6/TGFBR2/GADD45A/SOS1/CTNNB1/MAPK1/BAX/SMAD2/BRAF/AKT1/RALGDS/JUN/GSK3B/EREG/MAPK9/BBC3/TGFA/PIK3CA/FOS/CASP9/CDKN1A/BCL2/MTOR/RPS6KB1/AXIN1/MYC/MAPK8/TGFB2/TCF7	6.38538327818996
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	61/2085	138/9376	1.98775240677024	IL18/VAV3/CXCL8/IL6/TBK1/CASP1/FCGR2A/TNF/LCP2/IL1B/TLR4/NLRP3/CCL2/IRAK1/ACTR3/CHUK/TAB2/MAP2K3/IL10/NFKBIA/MEFV/MYD88/MAPK13/SKAP2/ARF6/MAP2K1/MAP3K7/GIT2/ELMO2/PIK3CB/TRAF6/VAV1/ACTR2/ARHGEF12/NFKB1/CDC42/ELMO1/MAPK1/ARPC1A/AKT1/IRAK4/JUN/PTK2B/WIPF1/GSK3B/RPS6KA1/NLRC4/ARHGEF7/MAPK9/IKBKB/PKN2/LIMK1/ARPC1B/PIK3CA/FOS/NFATC1/DOCK1/TICAM1/GNAQ/ARPC3/MAPK8	6.25091767919402
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	67/2085	157/9376	1.91905176495746	CXCL8/NBN/IL6/PPID/RB1/TRPM7/ZFP36L1/IL1A/NRAS/HLA-F/PTEN/HIPK1/MDM2/MAP2K3/CCND1/RAF1/PPP3R1/KRAS/SIRT1/MAPK13/HIPK3/MAP2K1/E2F4/HUS1/ATR/PPP1CC/ITPR2/PIK3CB/RHEB/ATM/PPP1CB/RBBP4/E2F3/TGFBR2/TRPV4/GADD45A/LIN54/NFKB1/PPP3CC/RAD9A/MAPK1/SMAD2/AKT1/MRE11/CDKN2B/VDAC1/SLC25A5/RASSF5/BTRC/VDAC2/MCU/TSC1/PIK3CA/NFATC1/ITPR1/RAD50/CDKN1A/CDKN2A/MTOR/FOXO3/MYC/SQSTM1/ZFP36L2/TGFB2/LIN9/CHEK1/CDK2	6.21002017155884
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	46/2085	94/9376	2.20060207153426	CXCL8/IL6/CCL20/TBK1/TNF/HSP90AA1/TNFAIP3/IL1B/S100A8/CEBPB/SRSF1/CCL2/CHUK/CASP8/TAB2/PTGS2/NFKBIA/TRAF3/HSP90AB1/MAPK13/CASP3/MAP3K7/CXCL1/TRAF6/USP25/IKBKE/ELAVL1/NFKB1/MAPK6/MAPK1/HSP90B1/JUN/GSK3B/CCL7/TAB3/MAPK9/CXCL10/IKBKB/CXCL3/MAPK7/FOS/FOSL1/JUND/MAPK8/CXCL2/S100A9	6.25586476472103
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	49/2085	103/9376	2.13929361365277	CXCL8/IL6/CCL3L1/TNF/TLR2/CALR/CCL3/IFNGR1/IL1B/IFNGR2/TLR4/CCL2/IRAK1/CHUK/CASP8/PPP2R2A/IL10/GNAI3/NFKBIA/MYD88/MAPK13/GNA15/TLR6/PIK3CB/TRAF6/PPP2CA/TGFBR2/PPP2CB/FAS/TNFRSF1A/NFKB1/MAPK1/SMAD2/AKT1/PPP2R2D/IRAK4/JUN/C1QC/MAPK9/IKBKB/PLCB2/PIK3CA/FOS/TICAM1/GNAQ/MAPK8/PLCB3/TGFB2/CFLAR	6.21712020228949
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	51/2085	109/9376	2.10404593756188	CXCL8/IL6/TBK1/CCL3L1/TNF/CD80/TLR2/TLR1/CCL3/MAP3K8/IL1B/TLR4/IRAK1/IRF7/CCL4L2/CHUK/CD40/CASP8/TAB2/MAP2K3/LY96/NFKBIA/TRAF3/MYD88/STAT2/MAPK13/IRF5/MAP2K1/MAP3K7/TLR6/PIK3CB/TRAF6/IKBKE/RIPK1/NFKB1/MAPK1/AKT1/IRAK4/IRF9/JUN/TLR3/CCL4/MAPK9/CXCL10/IKBKB/PIK3CA/FOS/TICAM1/TLR8/MAPK8/TICAM2	6.1997750246964
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	52/2085	112/9376	2.08783830078794	HSPA1B/HSPA1A/TNF/TLR2/IFNGR1/HSPA6/IFNGR2/TLR4/HLA-DQB1/HSPA8/IRAK1/BIRC2/CHUK/CD40/CASP8/TAB2/MAP2K3/IL10RA/IL10/GNAI3/LY96/NFKBIA/MYD88/ALOX5/SOCS1/CYCS/STAT3/MAPK13/PPIF/BCL2L1/IL10RB/CASP3/MAP3K7/TRAF6/JAK2/PIK3CG/TNFRSF1A/NFKB1/MAPK1/AKT1/IRAK4/XIAP/CCR5/HLA-DQA1/MAPK9/IKBKB/CASP9/BCL2/MAPK8/TGFB2/BIRC3/LDLR	6.19325842817824
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	60/2085	137/9376	1.96943758861524	BCL2A1/PMAIP1/CTSL/TNF/DDIT3/MCL1/CASP7/NRAS/TRAF1/BIRC2/CHUK/CASP8/RAF1/TNFRSF10B/KRAS/NFKBIA/BID/TNFRSF10A/CYCS/CTSB/CTSC/CTSS/EIF2S1/BCL2L1/CASP3/MAP2K1/CASP10/ITPR2/PIK3CB/ATM/ERN1/FAS/RIPK1/TNFRSF1A/GADD45A/NFKB1/EIF2AK3/MAPK1/BAX/AIFM1/AKT1/XIAP/JUN/PARP4/MAPK9/IKBKB/BBC3/SPTAN1/PIK3CA/FOS/ITPR1/CASP9/BCL2/TUBA1B/MAPK8/LMNB2/BIRC3/PARP2/IL3RA/CFLAR	6.11241416717833
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	95/2085	253/9376	1.68855271514014	IL18/RIPK2/CXCL8/TBK1/CASP1/UBE2D1/TNF/NAIP/PPID/IL1B/CYTH1/CGAS/TLR4/HK2/NLRP3/ARHGEF2/PRKCD/BCL10/ACTR3/HK3/CASP4/CHUK/UBE2N/TAB2/MDM2/NFKBIA/CD44/ATG5/MYD88/CYCS/RRAGC/MAPK13/BCL2L1/CUL1/ARF6/PIK3C3/MAP3K7/ELMO2/ITPR2/PIK3CB/TRAF6/UBE2D3/ATM/CALCOCO2/ACTR2/RIPK1/TNFRSF1A/NFKB1/HCLS1/ACTN1/CDC42/ELMO1/CYTH4/MAPK1/RRAGD/ARPC1A/BAX/WIPI1/AKT1/TNIP1/JUN/VDAC1/TIFA/GSK3B/BTRC/DIAPH1/NLRC4/TAB3/MAPK9/IKBKB/MAP1LC3B/PLCB2/ARPC1B/PIK3CA/ARF1/AKT1S1/ITPR1/DOCK1/BCL2/UBE2D4/MTOR/RPS6KB1/FOXO3/RRAGB/TECPR1/ARPC3/RPTOR/MYL12A/NOD1/SQSTM1/MAPK8/ATG16L1/SKP1/PLCB3/GLMN	5.93709143044789
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	65/2085	158/9376	1.84998330449564	FNIP2/LAMTOR3/TNF/SGK1/ATP6V1C1/FNIP1/EIF4E/NRAS/PTEN/CHUK/GRB2/RAF1/KRAS/ATP6V1H/ATP6V1B2/RICTOR/RRAGC/SESN2/CAB39/ATP6V1A/FZD5/MAP2K1/ATP6V1D/PIK3CB/RHEB/FLCN/SOS2/DVL3/TNFRSF1A/SOS1/MAPK1/RRAGD/SLC3A2/BRAF/FZD2/AKT1/MIOS/PRKAA1/GSK3B/ULK2/RPS6KA1/SLC38A9/IKBKB/SEH1L/PRKCA/TSC1/DDIT4/TBC1D7/ATP6V1G1/PRR5L/CLIP1/PRKCB/STRADB/PIK3CA/AKT1S1/SLC7A5/MTOR/RPS6KB1/RRAGB/RPTOR/ATP6V1E2/STRADA/LPIN3/DEPDC5/CASTOR2	5.76189985375488
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	79/2085	205/9376	1.73294496110429	IL6/TBK1/TNF/TLR2/CALR/TNFAIP3/RB1/PSMD11/HLA-DQB1/NFKBIE/ICAM1/IRAK1/OAS2/IRF7/HLA-F/SAP30/CHUK/CD40/CASP8/TAB2/MDM2/MAP2K3/CCND1/POLK/NFKBIA/CD44/TRAF3/PSMC6/MYD88/BID/PSMD12/ENTPD1/TAP1/STAT2/OAS1/BTK/JAK3/CYCS/STAT3/MAPK13/PSMC2/CASP3/CD58/MAP3K7/PIK3CB/TRAF6/IKBKE/BLNK/E2F3/FAS/RIPK1/GADD45A/USP7/NFKB1/PSMC4/CDKN1B/NFKB2/BAX/AKT1/IRAK4/IRF9/LYN/PSMD6/JUN/HLA-DQA1/SIN3A/MAPK9/CXCL10/IKBKB/PDIA3/TAP2/EIF2AK2/PIK3CA/CASP9/CDKN1A/BCL2/MYC/MAPK8/CDK2	5.67394427280354
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	47/2085	105/9376	2.01289025922119	IL6/CASP1/TNF/IL1B/PLK3/NLRP3/CLEC4E/PRKCD/NRAS/BCL10/CLEC7A/CHUK/CASP8/MDM2/IL10/RAF1/CYLD/PPP3R1/KRAS/PTGS2/NFKBIA/STAT2/MAPK13/IRF1/ITPR2/PIK3CB/IKBKE/EGR2/ARHGEF12/NFKB1/PPP3CC/NFKB2/MAPK1/AKT1/IRF9/JUN/MAPK9/IKBKB/FCER1G/EGR3/PIK3CA/NFATC1/ITPR1/IL23A/CD209/CLEC4D/MAPK8	5.58134505064903
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	38/2085	78/9376	2.19078890733567	FCGR2A/TNF/TLR2/IFNGR1/IL1B/IFNGR2/TLR4/HLA-DQB1/IL1A/IRAK1/FCGR1A/TAB2/IL10/FCGR3A/PTGS2/NFKBIA/MYD88/CR1/MAPK13/MAP3K7/TRAF6/NCF2/JAK2/NCF4/NCF1/NFKB1/MAPK1/MARCKSL1/IRAK4/JUN/HLA-DQA1/ITGAM/PRKCB/FOS/ELK1/CYBB/TGFB2/FCGR3B	5.64719038601595
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	59/2085	144/9376	1.84247268851585	CXCL8/IL6/TBK1/TNF/SCD/IL1B/TRA2A/TRA2B/TLR4/IRAK1/CHUK/CASP8/TAB2/MAP2K3/ADIPOR1/CCND1/LY96/NFKBIA/TRAF3/MYD88/SIRT1/SREBF1/ACOX1/MAPK13/CASP3/MAP3K7/CXCL1/ACADM/TRAF6/IKBKE/FAS/RIPK1/TNFRSF1A/ACADVL/ALDH3A2/C3AR1/NFKB1/CTNNB1/AKT1/IRAK4/C1QC/PRKAA1/GSK3B/ADIPOR2/TAB3/MAPK9/IKBKB/PRKAG2/CXCL3/ACACA/PRKAB1/TICAM1/FOXO3/MLYCD/MAPK8/LPIN3/CXCL2/TCF7/PRKAB2	5.44796485902307
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	75/2085	200/9376	1.6863309352518	IL18/CXCL8/IL6/CASP1/FCGR2A/TNF/NAIP/IL1B/CYTH1/TLR4/NLRP3/ARHGEF11/CASP7/SEC24A/ARHGEF2/IRAK1/ACTR3/NCK1/ABI1/CASP4/CHUK/CASP8/TAB2/TNFRSF10B/NFKBIA/MYD88/TNFRSF10A/CYCS/SEC24D/MYO1G/MAPK13/RAB1A/ARF6/CASP3/MYO1E/MAP3K7/TRAF6/MYO5A/LPAR5/MYO5B/TUBB2A/ACTR2/FAS/ARHGEF12/RIPK1/TNFRSF1A/NFKB1/HCLS1/CDC42/CYTH4/MAPK1/ARPC1A/BAX/IRAK4/JUN/WIPF1/NCK2/TAB3/CYFIP1/MAPK9/IKBKB/SEC24C/SEC24B/GNA13/ARPC1B/CLDN23/FOS/ARF1/CASP9/ARPC3/TUBA1B/OCLN/MAPK8/LPAR2/TUBB1	5.24646752011911
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	40/2085	90/9376	1.99861444177991	TLR2/IFNGR1/IFNGR2/TLR4/HIF1A/EML4/NFKBIE/NRAS/PTEN/CHUK/MAP2K3/RAF1/PPP3R1/KRAS/NFKBIA/MYD88/STAT3/MAPK13/MAP2K1/PIK3CB/TRAF6/CD274/JAK2/NFKB1/PPP3CC/MAPK1/AKT1/JUN/BATF/CSNK2A1/BATF3/IKBKB/PIK3CA/FOS/NFATC1/TICAM1/MTOR/RPS6KB1/BATF2/TICAM2	5.09037615956366
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	87/2085	250/9376	1.56491510791367	HSPA1B/HSPA1A/IL2RA/PDCD6IP/SNX3/HSPA6/CYTH1/RAB8A/ZFYVE16/SMURF2/SNX1/HSPA8/SPART/NEDD4L/ARAP1/ACTR3/PSD3/RAB10/HLA-F/SPG21/CAPZA2/DNM2/MDM2/VPS26A/IGF2R/ARFGAP3/STAM2/CHMP5/VPS37A/ARAP2/EHD4/RAB5A/ACAP2/RUFY1/ARF6/CAPZA1/VPS36/GIT2/ARFGEF2/IST1/ARF4/TRAF6/VPS45/VPS29/TSG101/RABEP1/RAB35/RAB7A/VTA1/RAB5B/TGFBR2/ACTR2/WASHC5/ARRB1/EPS15/CHMP7/CDC42/SNX2/CYTH4/CHMP2B/SNX4/ARPC1A/SMAD2/ASAP1/DAB2/GRK3/SH3GLB1/WASHC4/CCR5/WASHC2A/WIPF1/ARFGEF1/EPS15L1/ARRB2/ARPC1B/ARFGAP2/ARF1/AGAP2/ARFGAP1/ARPC3/LDLRAP1/SMAP2/SMURF1/CLTA/LDLR/AGAP4/AGAP5	4.84125635834872
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	23/2085	42/9376	2.46257850862167	ACSL1/SLC11A2/SAT1/ACSL3/ACSL4/GCLM/STEAP3/SLC39A8/ATG5/LPCAT3/PRNP/ACSL5/ATG7/SLC3A2/SAT2/HMOX1/VDAC2/MAP1LC3B/CYBB/PCBP2/PCBP1/FTL/TF	5.07989871455184
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	35/2085	77/9376	2.04403749727491	RB1/CHUK/CCND1/RAF1/POLK/KRAS/STAT3/BCL2L1/MAP2K1/SMAD4/PIK3CB/RALB/E2F3/TGFBR2/GADD45A/NFKB1/CDC42/MAPK1/BAX/SMAD2/BRAF/ARHGEF6/AKT1/RALGDS/MAPK9/IKBKB/TGFA/PIK3CA/CASP9/CDKN1A/CDKN2A/MTOR/RPS6KB1/MAPK8/TGFB2	4.91913174858346
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	70/2085	193/9376	1.63099365067531	VAV3/CXCL8/CCL20/CCL3L1/CCL8/CCL3/CCL2/FGR/PRKCD/NRAS/CCR1/CCL4L2/PREX1/CHUK/HCK/ADCY7/GRB2/RAF1/GNAI3/KRAS/NFKBIA/GNB4/STAT2/RAP1A/JAK3/GNG10/STAT3/MAP2K1/CXCL1/PIK3CB/VAV1/SOS2/JAK2/PIK3CG/NCF1/ARRB1/SOS1/NFKB1/CDC42/ELMO1/MAPK1/BRAF/AKT1/GRK3/LYN/CCR5/PTK2B/GSK3B/DOCK2/CCL4/CCL7/CXCL10/IKBKB/CCL18/CXCL3/PLCB2/ARRB2/ADCY3/PRKCB/PIK3CA/GNGT2/CCL23/CXCL16/CXCL12/FOXO3/GNG5/GNAQ/RAP1B/CXCL2/PLCB3	4.73648831569417
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	34/2085	75/9376	2.03858673061551	PMAIP1/SIAH1/SESN1/STEAP3/PTEN/MDM4/CASP8/MDM2/CCND1/TNFRSF10B/BID/TNFRSF10A/CYCS/SESN2/BCL2L1/RRM2B/CASP3/ATR/ATM/FAS/GADD45A/GORAB/BAX/COP1/RCHY1/PPM1D/BBC3/CASP9/CDKN1A/CDKN2A/BCL2/CCNG1/CHEK1/CDK2	4.82896099879797
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	42/2085	101/9376	1.8699907400812	CXCL8/IL6/TNF/IL1B/CCL2/PRKCD/ICAM1/IL1A/NRAS/CCND1/KRAS/STAT3/MAPK13/CASP3/SMAD4/PIM1/PIK3CB/TGFBR2/JAK2/STAT5A/NFKB1/CDKN1B/CDC42/MAPK1/BAX/SMAD2/AKT1/THBD/JUN/EGR1/DIAPH1/MAPK9/PRKCA/PLCB2/PRKCB/PIK3CA/NFATC1/BCL2/CYBB/MAPK8/PLCB3/TGFB2	4.70071018898532
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	62/2085	168/9376	1.65956377754939	CASP1/TNF/IFNGR1/MLKL/GLUL/HSP90AA1/PPID/TNFAIP3/IL1B/TRPM7/IFNGR2/TLR4/NLRP3/IL1A/PYGL/CAMK2D/BIRC2/CASP8/TNFRSF10B/CYLD/CHMP5/BID/STAT2/JAK3/TNFRSF10A/STAT3/HSP90AB1/DNM1L/STAT6/JAK2/PLA2G4A/FAS/RIPK1/TNFRSF1A/CHMP7/STAT5A/PLA2G4C/CHMP2B/BAX/AIFM1/IRF9/XIAP/VDAC1/GLUD1/SLC25A5/TLR3/PGAM5/VDAC2/MAPK9/EIF2AK2/BCL2/TICAM1/CYBB/SQSTM1/SPATA2/RIPK3/MAPK8/FTL/BIRC3/ZBP1/TICAM2/CFLAR	4.61289852420278
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	41/2085	98/9376	1.88134879851221	PTEN/CDS2/IPMK/MTMR4/MTMR3/PI4K2A/MTMR6/PIK3C3/ITPR2/IMPA1/PIK3CB/PIP4K2A/INPP4A/PPIP5K2/MTM1/PIKFYVE/PI4KB/SYNJ1/OCRL/PIP4K2C/SACM1L/PRKCA/MTMR2/PLCB2/PRKCB/PIK3CA/PPIP5K1/ITPR1/DGKG/PI4K2B/SYNJ2/IPPK/DGKD/INPP5E/INPP5B/CDS1/DGKE/PLCB3/DGKQ/MTMR1/DGKH	4.69006421826928
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	36/2085	83/9376	1.95045505764063	UBE2D1/PHC2/PHC3/SCML1/JARID2/PCGF5/OGT/MBD5/KDM2A/EZH2/EED/MTF2/UBE2D3/RBBP4/LCOR/USP7/MGA/RNF2/USP16/RYBP/BMI1/SUZ12/ASXL2/AEBP2/PCGF3/TEX10/PHC1/FBRS/L3MBTL4/PHF1/E2F6/SFMBT2/USP45/UBE2D4/SKP1/PHF19	4.65090835982062
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	31/2085	68/9376	2.05004937226689	BCL2A1/DUSP6/RUNX1/NRAS/CEBPA/CHUK/FCGR1A/GRB2/CCND1/RAF1/KRAS/PPARD/STAT3/MAP2K1/PIM1/PIK3CB/SOS2/STAT5A/SOS1/NFKB1/MAPK1/BRAF/AKT1/ITGAM/IKBKB/PIK3CA/MTOR/RPS6KB1/MYC/TCF7/PIM2	4.64709025573391
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/2085	59/9376	2.13411372596838	NRAS/PTEN/GRB2/CCND1/RAF1/POLK/KRAS/MAP2K1/PIK3CB/SOS2/MLH1/GADD45A/SOS1/CTNNB1/MAPK1/BAX/BRAF/AKT1/GSK3B/CTNNA1/PIK3CA/CASP9/CDKN1A/FOXO3/ELK1/AXIN1/MYC/TCF7	4.67293439092878
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/2085	133/9376	1.7243684751447	SOD2/IL6/KLF2/SGK1/PLK3/NRAS/SGK3/PTEN/CHUK/MDM2/GRB2/CCND1/IL10/RAF1/KRAS/SIRT1/BCL6/STAT3/MAPK13/HOMER3/MAP2K1/SMAD4/PIK3CB/SOS2/ATM/TGFBR2/GADD45A/USP7/NLK/SOS1/CDKN1B/MAPK1/BRAF/AKT1/CDKN2B/PRKAA1/PLK2/MAPK9/IKBKB/CAT/PRKAG2/CSNK1E/PRKAB1/PIK3CA/CDKN1A/AGAP2/FOXO3/MAPK8/TGFB2/CDK2/PRKAB2	4.49908298822948
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	38/2085	91/9376	1.87781906343057	VAV3/PIK3AP1/LILRB1/FCGR2B/NFKBIE/NRAS/BCL10/CHUK/GRB2/RAF1/PPP3R1/KRAS/NFKBIA/DAPP1/BTK/LILRB4/LILRA5/LILRA1/MAP2K1/PIK3CB/VAV1/BLNK/SOS2/SOS1/NFKB1/PPP3CC/MAPK1/AKT1/LYN/JUN/GSK3B/RASGRP3/IKBKB/PRKCB/PIK3CA/LILRB5/FOS/NFATC1	4.49966175914235
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	18/2085	32/9376	2.5294964028777	PMAIP1/CASP7/BIRC2/CASP8/BID/CYCS/BCL2L1/CASP3/BIRC6/TNFRSF1A/BAX/XIAP/MAPK9/BBC3/CASP9/BCL2/MAPK8/BIRC3	4.63449217206641
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	57/2085	157/9376	1.63262612839665	ADAM17/SIGLEC10/PTGER4/CASP1/ATP2A2/HAVCR2/MERTK/GPR132/ABCA1/SGK1/PPARG/CALR/ATP11B/CD47/NR1H3/HIF1A/CEBPB/CASP7/VPS8/CAMK2D/SIRPA/DUSP2/ITGAV/IL10/PTGS2/ALOX5/SIRT1/PPARD/ANO6/RAB5A/CH25H/MAPK13/CASP3/MAP2K1/TMEM30A/DUSP5/DNMT3A/P2RY6/ADAM9/RAB7A/RAB5B/JAK2/SCARF1/ARNT/ELMO1/MAPK1/ADAM10/VPS39/C1QC/ODC1/VPS33A/LIPA/DUSP8/PTGER2/NFATC1/DOCK1/LRP1	4.2746460734779
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	33/2085	77/9376	1.92723535457348	RB1/RUNX1/NRAS/CHUK/MDM2/GRB2/CCND1/RAF1/POLK/KRAS/NFKBIA/BCL2L1/MAP2K1/SMAD4/PIK3CB/SOS2/E2F3/TGFBR2/GADD45A/STAT5A/SOS1/NFKB1/CDKN1B/MAPK1/BAX/BRAF/AKT1/IKBKB/PIK3CA/CDKN1A/CDKN2A/MYC/TGFB2	4.36880177483746
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	56/2085	155/9376	1.62468012686625	CTSL/FCGR2A/SEC22B/TLR2/CALR/ATP6V1C1/MSR1/M6PR/LAMP1/TLR4/FCGR2B/HLA-DQB1/STX7/CLEC7A/STX12/HLA-F/FCGR1A/ITGAV/FCGR3A/ATP6V1H/ATP6V1B2/TAP1/RAB5A/CTSS/ATP6V1A/ATP6V0A1/PIK3C3/ATP6V1D/TLR6/TUBB2A/RAB7A/NCF2/RAB5B/NCF4/SEC61B/NCF1/PIKFYVE/COLEC12/HLA-DQA1/OLR1/CANX/MARCO/ITGAM/STX18/ATP6V1G1/TAP2/LAMP2/CD209/FCAR/TUBA1B/ATP6V1E2/CYBB/ATP6V0D2/MRC1/FCGR3B/TUBB1	4.19352896086278
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/2085	73/9376	1.90963503170067	RB1/EML4/NRAS/GRB2/CCND1/RAF1/POLK/KRAS/JAK3/STAT3/MAP2K1/PIK3CB/SOS2/E2F3/GADD45A/STAT5A/FHIT/SOS1/MAPK1/BAX/BRAF/AKT1/RASSF5/PRKCA/TGFA/PRKCB/PIK3CA/CASP9/CDKN1A/CDKN2A/FOXO3	4.17217211189957
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	34/2085	83/9376	1.84209644332727	IL18/IL6/TBK1/CASP1/MLKL/IL1B/CGAS/NLRP3/CASP7/G3BP1/AIM2/IRF7/GSDME/CCL4L2/CHUK/CASP8/NFKBIA/MEFV/IFI16/POLR2K/CASP3/IKBKE/RIPK1/NFKB1/ADAR/CCL4/POLR3C/CXCL10/IKBKB/POLR3F/ZCCHC3/RIPK3/PCBP1/ZBP1	4.12067183667596
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	52/2085	144/9376	1.62387423394618	ATP2A2/XBP1/PSMA3/PSMD11/PSMA6/PSMA2/PSMC6/NRBF2/PSMD12/ATXN2L/OPA1/SP1/CYCS/PSMA1/ATXN1/PPIF/GTF2B/PSMC2/PIK3C3/PUM1/ITPR2/PIK3CB/PSMA5/ERN1/PUM2/PSMC4/WIPI1/AKT1/PSMD6/NFYA/VDAC1/PSMD9/SLC25A5/ULK2/ATG2B/VDAC2/MAPK9/PRKCA/TBP/MCU/PLCB2/PRKCB/ATXN1L/TBPL1/PIK3CA/ITPR1/OMA1/MTOR/GNAQ/MAPK8/PLCB3/KCNC3	4.03436805646044
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	40/2085	103/9376	1.7463621335941	DDX39B/ACIN1/PAPOLA/NXF1/PABPN1/PPP2R2A/CPSF6/EIF4A3/RNGTT/PCF11/SMG1/RNMT/PPP1CC/RNPS1/PPP2CA/PPP1CB/TARDBP/NXT2/PPP2CB/PYM1/ETF1/FUS/PPP2R2D/CPSF7/WDR33/DAZAP1/PPP2R5C/MAGOH/SYMPK/PPP2R3C/PAPOLG/ALYREF/PNN/DDX19B/NCBP1/NXT1/DDX19A/CSTF1/CLP1/CSTF2	4.07289485641406
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	45/2085	120/9376	1.6863309352518	RIPK2/IRAK3/IRAK2/NFKBIE/PRKCD/NRAS/IRAK1/CAMK2D/MAP3K1/PSEN1/GRB2/RAF1/KRAS/NFKBIA/RAP1A/MAPK13/MAP2K1/PIK3CB/TRAF6/SOS2/SOS1/NFKB1/CDC42/MAPK1/BAX/BRAF/AKT1/IRAK4/JUN/RAPGEF1/ZNF274/GSK3B/SORT1/RPS6KA1/SH2B3/MAPK9/IKBKB/MAPK7/PIK3CA/BCL2/SH2B2/FOXO3/RAP1B/MAPK8/NTRK3	4.04629593997536
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	94/2085	300/9376	1.40902318145484	HSPA1B/HSPA1A/LAMTOR3/TNF/MAP3K8/DDIT3/DUSP6/MKNK1/IL1B/HSPA6/DUSP1/NF1/DUSP10/HSPA8/RAPGEF2/ATF2/IL1A/NRAS/TAOK3/IRAK1/MKNK2/CHUK/DUSP2/DUSP3/TAB2/MAP3K1/MAP2K3/GRB2/RAF1/IL1RAP/PPP3R1/KRAS/PDGFB/MYD88/RAP1A/MAP4K3/PPM1B/MAPK13/RASA2/CASP3/MAP2K1/DUSP5/ELK4/MAP3K7/TRAF6/SOS2/TGFBR2/PLA2G4A/FAS/TNFRSF1A/CSF1/GADD45A/NLK/ARRB1/SOS1/NFKB1/PPP3CC/CDC42/NFKB2/PLA2G4C/MAPK1/MAP3K13/BRAF/AKT1/IRAK4/STK3/MAPKAPK5/JUN/EREG/RPS6KA1/RASGRP3/MAP3K2/MAPK9/IKBKB/PRKCA/MAP3K12/ARRB2/TGFA/MAPK7/PRKCB/PTPN7/DUSP8/FOS/NFATC1/ELK1/ECSIT/RAP1B/MYC/JUND/MAPK8/TGFB2/NR4A1/MAP3K10/MAP3K21	3.8504051088381
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	32/2085	78/9376	1.8448748693353	PTEN/IPMK/MTMR4/MTMR3/PI4K2A/MINPP1/MTMR6/PIK3C3/IMPA1/PIK3CB/PIP4K2A/INPP4A/PPIP5K2/MTM1/PIK3CG/PIKFYVE/PI4KB/SYNJ1/OCRL/PIP4K2C/SACM1L/MTMR2/PLCB2/PIK3CA/PPIP5K1/PI4K2B/SYNJ2/IPPK/INPP5E/INPP5B/PLCB3/MTMR1	4.00672966476656
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	32/2085	78/9376	1.8448748693353	CXCL8/IL6/CASP1/IRF8/TNF/IL1B/TLR4/NLRP3/CASP7/IL1A/IRAK1/IL10/GNAI3/LY96/MYD88/MAPK13/CASP3/IRF1/TRAF6/NFKB1/MAPK1/IRAK4/JUN/C1QC/ITGAM/MAPK9/FOS/TICAM1/IL23A/NOD1/MAPK8/TICAM2	4.00672966476656
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2085	98/9376	1.74368913032839	VAV3/FCGR2A/FCGR2B/PRKCD/MARCKS/ACTR3/FCGR1A/HCK/DNM2/RAF1/FCGR3A/VASP/LIMK2/ARF6/MAP2K1/PIK3CB/VAV1/ACTR2/PLA2G4A/NCF1/CDC42/PLA2G4C/MAPK1/MARCKSL1/ARPC1A/AKT1/ASAP1/LYN/PRKCA/LIMK1/ARPC1B/PRKCB/PIK3CA/DOCK1/RPS6KB1/ARPC3/PTPRC/FCGR3B	3.95751351287586
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/2085	122/9376	1.65868616582144	VAV3/TNF/LCP2/MAP3K8/NFKBIE/NRAS/BCL10/NCK1/CHUK/GRB2/PPP2R2A/IL10/RAF1/PPP3R1/KRAS/NFKBIA/MAPK13/MAP2K1/MAP3K7/PIK3CB/PPP2CA/VAV1/SOS2/PPP2CB/SOS1/NFKB1/PPP3CC/CDC42/MAPK1/AKT1/PPP2R2D/JUN/PPP2R5C/PPP2R3C/GSK3B/NCK2/DLG1/MAPK9/IKBKB/PIK3CA/FOS/NFATC1/TEC1/MAPK8/PTPRC	3.91596524485823
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	37/2085	95/9376	1.75141739240187	IL18/CXCL8/IL6/CCL20/CTSL/CCL3L1/TNF/CD80/TLR2/CCL3/ATP6V1C1/IL1B/TLR4/HLA-DQB1/CCL2/ICAM1/IL1A/ATP6V1H/ATP6V1B2/ATP6V1A/ATP6V0A1/ATP6V1D/CXCL1/CSF1/JUN/HLA-DQA1/CXCL3/ATP6V1G1/TNFSF13/FOS/TNFSF13B/CXCL12/IL23A/ATP6V1E2/ATP6V0D2/CXCL2/TGFB2	3.93632345604615
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	41/2085	109/9376	1.69148791058896	IL6/IL2RA/IFNGR1/HSP90AA1/IL1B/IFNGR2/HIF1A/AHR/HLA-DQB1/NFKBIE/RUNX1/CHUK/IL1RAP/PPP3R1/NFKBIA/JAK3/STAT3/HSP90AB1/IL4R/MAPK13/SMAD4/STAT6/TGFBR2/JAK2/IL27RA/STAT5A/NFKB1/PPP3CC/MAPK1/SMAD2/JUN/HLA-DQA1/MAPK9/IKBKB/FOS/NFATC1/MTOR/IL23A/IL6R/MAPK8/IL12RB1	3.88305353255164
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	40/2085	106/9376	1.69693679019049	PLAU/HSP90AA1/RB1/ETV5/NRAS/PTEN/CHUK/MDM2/GRB2/CCND1/RAF1/KRAS/NFKBIA/PDGFB/HSP90AB1/MAP2K1/PIK3CB/SOS2/E2F3/SOS1/NFKB1/CTNNB1/CDKN1B/MAPK1/HSP90B1/BRAF/AKT1/GSK3B/IKBKB/TGFA/PIK3CA/CASP9/CDKN1A/BCL2/MTOR/CREB5/TCF7/NKX3-1/SLC19A1/CDK2	3.85879382734458
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	17/2085	33/9376	2.31657583024489	SEC22B/SNAP23/STX6/STX7/GOSR2/STX3/GOSR1/VTI1A/STX11/VAMP7/STX5/STX4/BET1/STX2/STX18/BNIP1/VAMP1	4.05139690776744
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	29/2085	70/9376	1.8629941760877	HIF1A/NRAS/GRB2/VHL/RAF1/KRAS/PDGFB/RAP1A/CUL2/MAP2K1/PIK3CB/FLCN/SOS2/PRCC/SOS1/ELOC/ARNT/CDC42/MAPK1/BRAF/FH/AKT1/JUN/RAPGEF1/TGFA/PIK3CA/CDKN1A/RAP1B/TGFB2	3.87543519963971
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	29/2085	71/9376	1.83675482149492	ADAM17/CXCL8/ATP6V1C1/CHUK/ATP6V1H/NFKBIA/ATP6V1B2/MAPK13/ATP6V1A/ATP6V0A1/CASP3/ATP6V1D/CXCL1/F11R/NFKB1/CDC42/ADAM10/LYN/JUN/HBEGF/MAPK9/IKBKB/CXCL3/ATP6V1G1/NOD1/ATP6V1E2/MAPK8/ATP6V0D2/CXCL2	3.78455070170107
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	67/2085	205/9376	1.46971281511376	PMAIP1/GTF2H2/RB1/ATF2/NRAS/TRAF1/IRF7/HLA-F/GTF2H1/CASP8/MDM2/GRB2/CCND1/KRAS/NFKBIA/TRAF3/DDX3X/JAK3/STAT3/RASA2/GTF2B/CASP3/YWHAG/GTF2H3/UBE3A/PIK3CB/POLB/VAC14/GTF2A2/EGR2/ATF6B/USP7/STAT5A/NFKB1/CDKN1B/ACTN1/CDC42/NFKB2/MAPK1/BAX/IRF9/LYN/CDKN2B/JUN/SP100/CCR5/HDAC8/DLG1/RANBP1/TBP/GTF2H2C/YWHAH/EIF2AK2/KAT2B/TBPL1/EGR3/PIK3CA/CDKN1A/CDKN2A/DNAJA3/GTF2E1/CREB5/KAT2A/ATP6V0D2/HDAC4/CHEK1/CDK2	3.63618617851164
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	31/2085	78/9376	1.78722252966857	HSPD1/HSPA9/PATL1/BTG2/DCP2/XRN1/LSM6/CNOT2/CNOT4/LSM8/C1D/EXOSC10/LSM5/CNOT8/EXOSC3/PNPT1/DDX6/CNOT1/DCP1A/BTG3/TOB1/CNOT10/PAN3/CNOT3/MPHOSPH6/CNOT9/BTG1/TENT4A/PAN2/ZCCHC7/EDC4	3.73331954455833
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	29/2085	72/9376	1.81124433786304	TANK/CXCL8/TBK1/AZI2/TNF/TRIM25/IRF7/CHUK/CASP8/MAP3K1/CYLD/NFKBIA/ATG5/TRAF3/DDX3X/MAPK13/SIKE1/MAP3K7/CASP10/TRAF6/IKBKE/RIPK1/NFKB1/ADAR/IFIH1/MAPK9/CXCL10/IKBKB/MAPK8	3.69511700451258
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	49/2085	142/9376	1.55174114229743	CTSL/KLF2/TNF/HSP90AA1/SDC4/IL1B/DUSP1/CCL2/ARHGEF2/ICAM1/IL1A/CHUK/ITGAV/PDGFB/SDC2/HSP90AB1/MAPK13/MAP3K7/PIK3CB/SUMO1/NCF2/TXN/TNFRSF1A/TRPV4/NCF1/NFKB1/CTNNB1/HSP90B1/AKT1/ACVR1/MEF2A/THBD/JUN/GSTO1/PRKAA1/HMOX1/MAPK9/IKBKB/SUMO4/PIAS4/MAPK7/PIK3CA/FOS/BCL2/SQSTM1/MAPK8/SUMO2/ACVR2A/NQO1	3.54266205363129
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	35/2085	93/9376	1.69237513215234	PRKCD/NRAS/CAMK2D/MAP3K1/ADCY7/MAP2K3/GRB2/RAF1/KRAS/MAPK13/MAP2K1/ITPR2/SOS2/PLA2G4A/SOS1/CDC42/PLA2G4C/MAPK1/JUN/EGR1/PTK2B/HBEGF/MAP3K2/MAPK9/PRKCA/PLCB2/ADCY3/MAPK7/PRKCB/MMP14/ITPR1/ELK1/GNAQ/MAPK8/PLCB3	3.58825979334918
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	35/2085	93/9376	1.69237513215234	RB1/TRAF1/BIRC2/PTEN/CHUK/ITGAV/CCND1/POLK/PTGS2/NFKBIA/TRAF3/CYCS/BCL2L1/CASP3/PIK3CB/TRAF6/E2F3/CKS2/GADD45A/FHIT/NFKB1/CDKN1B/BAX/AKT1/XIAP/CDKN2B/ZBTB17/IKBKB/PIK3CA/CASP9/CDKN1A/BCL2/MYC/BIRC3/CDK2	3.58825979334918
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	29/2085	73/9376	1.78643277159095	PDCD6IP/ELL2/MX1/APOBEC3G/CCNT2/CPSF6/XPO1/TRIM5/SERINC5/APOBEC3A/ELL/TSG101/NUP153/CDK9/AFF4/CPSF7/MAP1S/TNPO3/CCR5/NELFCD/KAT2B/RANBP2/MX2/APOBEC3F/CCNT1/KAT2A/NELFA/BST2/APOBEC3H	3.60708719779753
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	34/2085	90/9376	1.69882227551292	SOD2/PPARG/EIF4E/SESN1/ATF2/NRAS/ADCY7/ADIPOR1/KRAS/ATG5/SIRT1/SESN2/PIK3CB/RHEB/EHMT1/ATF6B/NFKB1/BAX/AKT1/PRKAA1/ADIPOR2/CAT/PRKAG2/TSC1/ADCY3/PRKAB1/PIK3CA/AKT1S1/MTOR/RPS6KB1/FOXO3/CREB5/RPTOR/PRKAB2	3.56220389192711
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/2085	71/9376	1.77341844833992	SOCS6/NRAS/SOCS3/GRB2/CCND1/RAF1/KRAS/SOCS1/SOCS4/STAT3/MAPK13/MAP2K1/IRF1/PIK3CB/SOS2/JAK2/STAT5A/SOS1/NFKB1/MAPK1/AKT1/GSK3B/MAPK9/PIK3CA/FOS/FOXO3/MAPK8/SOCS7	3.49808720091275
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	36/2085	99/9376	1.63522999781993	RB1/NRAS/ADCY7/MDM2/GRB2/CCND1/RAF1/KRAS/SP1/MAPK13/MAP2K1/PIK3CB/SOS2/E2F3/SOS1/CDKN1B/MAPK1/BAX/BRAF/NOTCH2/AKT1/JUN/NCOA3/DLL1/HBEGF/MAPK9/ADCY3/PIK3CA/FOS/CDKN1A/CDKN2A/BCL2/MTOR/RPS6KB1/MAPK8/JAG1	3.39773838529601
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	36/2085	99/9376	1.63522999781993	GPCPD1/HIF1A/NRAS/GRB2/RAF1/KRAS/PDGFB/SP1/MAP2K1/CHPT1/PIK3CB/RHEB/SOS2/PLA2G4A/SOS1/PLA2G4C/MAPK1/AKT1/RALGDS/JUN/CHKA/MAPK9/PRKCA/TSC1/PRKCB/PIK3CA/FOS/DGKG/MTOR/RPS6KB1/DGKD/MAPK8/DGKE/DGKQ/DGKH/CHKB	3.39773838529601
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	25/2085	62/9376	1.81325907016322	SOD2/HSPA1B/HSPA1A/HSPA6/HSPA8/NRAS/ADCY7/KRAS/ATG5/SIRT1/PIK3CB/AKT1/PRKAA1/CAT/CLPB/PRKAG2/ADCY3/PRKAB1/PIK3CA/AKT1S1/MTOR/RPS6KB1/FOXO3/RPTOR/PRKAB2	3.43559342002795
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	27/2085	69/9376	1.75964967156709	VAV3/TNF/LCP2/NRAS/MAP2K3/GRB2/RAF1/KRAS/ALOX5/BTK/MAPK13/MAP2K1/PIK3CB/VAV1/SOS2/PLA2G4A/SOS1/PLA2G4C/MAPK1/AKT1/LYN/MAPK9/PRKCA/FCER1G/PIK3CA/ALOX5AP/MAPK8	3.38671118102129
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	32/2085	86/9376	1.67325860242039	NRAS/ABL2/CAMK2D/NCK1/GRB2/RAF1/KRAS/MAP2K1/PIK3CB/SOS2/STAT5A/SOS1/CDKN1B/MAPK1/BRAF/AKT1/JUN/GSK3B/NCK2/EREG/HBEGF/MAPK9/PRKCA/TGFA/PRKCB/PIK3CA/CDKN1A/MTOR/RPS6KB1/ELK1/MYC/MAPK8	3.35404124283367
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/2085	125/9376	1.54692757793765	TNF/NRAS/CERS2/PTEN/NSMAF/SGMS1/SGPP1/PPP2R2A/RAF1/GNAI3/KRAS/BID/SPTLC1/MAPK13/MAP2K1/ADORA3/ORMDL1/DEGS1/PIK3CB/PPP2CA/PPP2CB/TNFRSF1A/NFKB1/ABCC1/MAPK1/BAX/AKT1/PPP2R2D/PPP2R5C/PPP2R3C/MAPK9/PRKCA/ASAH1/PLCB2/FCER1G/GNA13/PRKCB/PIK3CA/BCL2/GNAQ/MAPK8/SGMS2/PLCB3	3.29181642050421
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	31/2085	83/9376	1.67955852185721	SOD2/ACSL1/FAR1/IDH1/ACSL3/ACSL4/AGPS/HSD17B4/SCP2/ACOX1/FAR2/PHYH/ACSL5/PEX2/ABCD4/PEX13/CAT/PEX14/DHRS4/CROT/MLYCD/ABCD3/ECI2/PRDX1/MPV17L2/NUDT19/HACL1/PEX3/DDO/NUDT7/EHHADH	3.32531705195898
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	42/2085	122/9376	1.54810708810001	PPARG/SCD/RAB8A/RAB10/ADIPOR1/CCND1/PPP2R2A/SIRT1/SREBF1/CAB39/MAP3K7/PIK3CB/RHEB/PPP2CA/PFKFB3/PPP2CB/ELAVL1/AKT1/PPP2R2D/PPP2R5C/PPP2R3C/HMGCR/PRKAA1/ADIPOR2/PRKAG2/TSC1/ACACA/CRTC2/PRKAB1/STRADB/PIK3CA/AKT1S1/MTOR/RPS6KB1/EEF2K/FOXO3/MLYCD/CREB5/PFKFB4/RPTOR/STRADA/PRKAB2	3.258559870896
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	30/2085	80/9376	1.6863309352518	IL6/NF1/EIF4E/NRAS/PTEN/GRB2/RAF1/KRAS/PDGFB/STAT3/BCL2L1/MAP2K1/PIK3CB/SOS2/JAK2/SOS1/MAPK1/BAX/BRAF/AKT1/GSK3B/PRKCA/TGFA/PRKCB/PIK3CA/BCL2/MTOR/RPS6KB1/IL6R/FOXO3	3.29667116260002
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	46/2085	138/9376	1.49896083133493	MKNK1/HK2/EIF4E/NRAS/PYGL/HK3/MKNK2/SOCS3/GRB2/RAF1/KRAS/SREBF1/SOCS1/SOCS4/RHOQ/MAP2K1/PPP1CC/PIK3CB/RHEB/PHKB/SOS2/PPP1CB/SOS1/MAPK1/BRAF/AKT1/RAPGEF1/PRKAA1/GSK3B/PPP1R3B/MAPK9/IKBKB/PRKAR1A/PRKAG2/TSC1/ACACA/PRKAB1/PIK3CA/PPP1R3E/SH2B2/MTOR/RPS6KB1/ELK1/RPTOR/MAPK8/PRKAB2	3.15763652959884
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	28/2085	75/9376	1.67883613109512	PMAIP1/BIRC2/CASP8/MDM2/BID/CYCS/BCL2L1/CASP3/SLC31A1/PIK3CB/TOP2B/ATM/MLH1/MSH6/FAS/MAPK1/BAX/AKT1/XIAP/GSTO1/ATP7A/BBC3/PIK3CA/CASP9/CDKN1A/CDKN2A/BCL2/BIRC3	3.15628257612202
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	10/2085	18/9376	2.49826805222489	MANBA/FUCA1/NEU3/NEU1/HEXA/MAN2B1/ENGASE/MAN2C1/NEU4/HEXB	3.40235299639813
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	14/2085	30/9376	2.09854516386891	IL6/TNF/IL1B/CHUK/ABCC3/GART/ABCC5/NFKB1/ABCC1/FPGS/IKBKB/SHMT1/ABCG2/SLC19A1	3.222632438213
Human Diseases	Cancer: specific types	hsa05214	Glioma	28/2085	76/9376	1.65674618200177	RB1/NRAS/CAMK2D/PTEN/MDM2/GRB2/CCND1/RAF1/POLK/KRAS/PDGFB/MAP2K1/PIK3CB/SOS2/E2F3/GADD45A/SOS1/MAPK1/BAX/BRAF/AKT1/PRKCA/TGFA/PRKCB/PIK3CA/CDKN1A/CDKN2A/MTOR	3.07402926210624
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	62/2085	201/9376	1.38709808272785	PLAU/BCL2A1/CXCL8/IL6/NFKBIZ/PPARG/DDIT3/DUSP6/ETV5/CEBPB/RUNX1/CEBPA/TRAF1/BIRC2/CD40/CCNT2/ETV6/FCGR1A/MDM2/ID2/POLK/DDX5/EWSR1/BCL6/SP1/AFF1/KDM6A/BCL2L1/JMJD1C/ELK4/CDK14/BMP2K/ATF1/PRCC/ATM/TGFBR2/DOT1L/GADD45A/FUS/NFKB1/CDK9/CDKN1B/BAX/BMI1/MITF/SIN3A/PBX3/ITGAM/HHEX/ZBTB17/LMO2/NSD2/MLF1/PAX8/CDKN1A/RUNX2/SS18L1/MAF/CCNT1/MYC/BIRC3/ETV7	2.96661461045415
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	53/2085	168/9376	1.4186593582277	IL6/IL2RA/IFNGR1/SOCS6/MCL1/IFNGR2/IL15RA/OSM/PTPN2/SOCS3/PIAS1/GRB2/IL10RA/CCND1/IL10/RAF1/STAM2/PDGFB/CSF3R/STAT2/JAK3/SOCS1/SOCS4/STAT3/IL4R/BCL2L1/IL10RB/PIM1/PIK3CB/STAT6/SOS2/JAK2/PIAS2/IL27RA/STAT5A/SOS1/AKT1/IRF9/PIAS4/IL13RA1/IL7/PIK3CA/CDKN1A/BCL2/MTOR/IL23A/IL6R/MYC/LIF/IL12RB1/IL3RA/PIAS3/SOCS7	2.9280460835611
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	24/2085	63/9376	1.71309809295421	ACAT2/COLGALT1/SETD2/NSD1/EZH2/EHMT1/DOT1L/ALDH3A2/PHYKPL/DLD/SETDB2/SETDB1/KMT2C/NSD2/ASH1L/KMT5A/PRDM2/KMT2D/SMYD2/TMLHE/KMT2E/CAMKMT/KMT5C/EHHADH	3.03682570625365
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2085	37/9376	1.94459783524532	PPARG/NRAS/TFG/CCND1/POLK/KRAS/MAP2K1/GADD45A/CTNNB1/MAPK1/BAX/BRAF/PAX8/CDKN1A/MYC/TCF7	3.0785253847759
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/2085	34/9376	1.98391874735506	NFIL3/BHLHE41/BHLHE40/CUL1/FBXL3/CSNK1D/PRKAA1/BTRC/PRKAG2/CSNK1E/PRKAB1/PER1/CRY1/SKP1/PRKAB2	3.07343392930944
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	18/2085	44/9376	1.83963374754742	GTF2H2/GTF2H1/CCNH/TAF7/GTF2B/GTF2H3/TAF13/GTF2F2/GTF2A2/TAF9/TAF12/TBP/GTF2H2C/TBPL1/TAF5L/GTF2I/TAF8/GTF2E1	2.98520374551647
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/2085	41/9376	1.86456103409955	CXCL8/DAPK1/RB1/NRAS/MDM2/CCND1/RAF1/KRAS/MAP2K1/E2F3/MAPK1/BRAF/HBEGF/CDKN1A/CDKN2A/MYC/DAPK2	2.96671306284245
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	40/2085	122/9376	1.47438770295239	ATP2A2/HIF1A/NRAS/ITGAV/MDM2/CCND1/RAF1/KRAS/MAP2K1/PIK3CB/RHEB/ATP1A1/MED13/MED30/MED14/NCOA2/CTNNB1/MAPK1/NOTCH2/AKT1/RCAN1/SIN3A/GSK3B/NCOA3/MED17/PRKCA/PLCB2/ATP1B1/PRKCB/KAT2B/PIK3CA/SLC9A1/CASP9/MTOR/FXYD2/KAT2A/MYC/THRB/MED12/PLCB3	2.82028962158784
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	103/2085	368/9376	1.25863830674591	TANK/HSPA5/HNRNPA2B1/TBK1/CASP1/SRSF7/TNF/C9orf72/HNRNPA3/DDIT3/XBP1/PSMA3/PSMD11/PSMA6/NUP58/RAB8A/PSMA2/SDHD/NXF1/MAP2K3/SPG11/PPP3R1/SRSF3/PSMC6/NUP98/BID/NRBF2/PSMD12/NUP62/ATXN2L/SETX/CYCS/RAB5A/PSMA1/MAPK13/RAB1A/UBQLN2/EIF2S1/BCL2L1/UBQLN1/DCTN4/PSMC2/CASP3/NUP54/PIK3C3/SDHB/PSMA5/SMCR8/NUP153/ERN1/TUBB2A/TARDBP/ACTR10/NXT2/NDUFB5/TNFRSF1A/FUS/ANXA7/POM121C/PPP3CC/EIF2AK3/PSMC4/NUP205/CHMP2B/BAX/WIPI1/NDUFB3/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/ULK2/MT-ND6/ATG2B/CAT/SEH1L/NUP160/MAP1LC3B/MCU/NUP107/ALYREF/NCBP1/RANBP2/NUP133/NXT1/ALS2/NUP93/CASP9/BCL2/MTOR/NUP88/NUP43/HNRNPA1/TUBA1B/SQSTM1/DNAH3/NUP35/NDUFA7/DNAH14/NUP188/MT-ND4L/TUBB1	2.70674714701035
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	49/2085	157/9376	1.40348561914799	CXCL8/IL6/TNF/PPARG/DDIT3/XBP1/IL1B/NR1H3/CASP7/SDHD/IL1A/CEBPA/SOCS3/MLX/CASP8/ADIPOR1/BID/SREBF1/CYCS/MAPK13/EIF2S1/CASP3/SDHB/PIK3CB/ERN1/FAS/NDUFB5/TNFRSF1A/NFKB1/EIF2AK3/CDC42/BAX/NDUFB3/AKT1/JUN/UQCRC2/PRKAA1/GSK3B/ADIPOR2/MAPK9/IKBKB/PRKAG2/PRKAB1/PIK3CA/FOS/IL6R/MAPK8/NDUFA7/PRKAB2	2.72634679501315
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	35/2085	105/9376	1.49896083133493	TBK1/HIF1A/SMURF2/SIAH1/NRAS/KRAS/OPA1/CCZ1/SP1/USP15/RAB5A/EIF2S1/BCL2L1/BCL2L13/ARIH1/RABGEF1/RHOT1/CALCOCO2/RAB7A/RAB5B/EIF2AK3/JUN/MITF/MTX2/PGAM5/CSNK2A1/MAPK9/CCZ1B/MAP1LC3B/FOXO3/MFN1/SQSTM1/MAPK8/SMURF1/MTX3	2.74943167938077
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/2085	20/9376	2.2484412470024	HSD17B7/LBR/SQLE/MSMO1/LSS/LIPA/SC5D/CYP2R1/CYP27B1/DHCR7	2.9887054725258
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	36/2085	109/9376	1.4852088971025	IL6/TNF/NR1H3/PRKCD/PYGL/PTEN/SOCS3/MLX/NFKBIA/SREBF1/OGT/STAT3/PPP1CC/PIK3CB/PPP1CB/TNFRSF1A/NFKB1/AKT1/PRKAA1/GSK3B/RPS6KA1/PPP1R3B/MAPK9/IKBKB/PRKAG2/CRTC2/PRKAB1/PRKCB/PIK3CA/PPP1R3E/MTOR/RPS6KB1/CREB5/MAPK8/TRIB3/PRKAB2	2.72469278647926
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	24/2085	66/9376	1.63522999781993	IL18/IL6/TNF/TLR2/IFNGR1/IL1B/IFNGR2/TLR4/HLA-DQB1/IL1A/IL10/STAT3/IL4R/STAT6/NFKB1/SMAD2/JUN/HLA-DQA1/NOD2/NFATC1/IL23A/MAF/IL12RB1/TGFB2	2.76932065476495
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	52/2085	170/9376	1.37551699816617	RB1/NRAS/TXNRD1/PTEN/GRB2/CCND1/RAF1/POLK/KRAS/SMARCE1/BCL2L1/FZD5/MAP2K1/SMAD4/PIK3CB/SOS2/E2F3/ARID2/TGFBR2/DVL3/PBRM1/BRD7/GADD45A/ARID1B/ACTL6A/SOS1/CTNNB1/MAPK1/BAX/SMAD2/BRAF/FZD2/AKT1/CSNK1A1/GSTO1/GSK3B/HMOX1/PRKCA/TGFA/PRKCB/PIK3CA/CDKN1A/CDKN2A/MTOR/RPS6KB1/ELK1/AXIN1/FRAT2/MYC/TGFB2/TCF7/NQO1	2.64218787177531
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	25/2085	70/9376	1.60602946214457	ACSL1/TNF/ACSL3/ACSL4/NFKBIE/CHUK/SOCS3/ADIPOR1/NFKBIA/STAT3/JAK2/TNFRSF1A/NFKB1/ACSL5/AKT1/PRKAA1/ADIPOR2/MAPK9/IKBKB/PRKAG2/PRKAB1/MTOR/MAPK8/POMC/PRKAB2	2.72148755425102
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	36/2085	110/9376	1.47170699803793	IL6/IFNGR1/MKNK1/IFNGR2/TLR4/HK2/HIF1A/EIF4E/CAMK2D/HK3/MKNK2/VHL/CUL2/STAT3/MAP2K1/PDK1/PIK3CB/PFKFB3/ALDOA/NFKB1/ELOC/CDKN1B/ARNT/MAPK1/AKT1/HMOX1/PRKCA/PRKCB/PIK3CA/CDKN1A/BCL2/MTOR/RPS6KB1/IL6R/CYBB/TF	2.66113944677003
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	33/2085	100/9376	1.48397122302158	IL18/CXCL8/IL6/CCL20/CCL3L1/IL2RA/TNF/CCL8/CCL3/CCL2/CCR1/CCL4L2/IL10RA/IL10/TNFRSF10B/TNFRSF10A/IL10RB/CXCL1/TNFRSF1A/CSF1/TNFRSF10D/TNFRSF14/CCR5/CCL4/CCL7/CXCL10/CCL18/CXCL3/CCL23/CXCL12/IL6R/ACKR3/CXCL2	2.60186217765772
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	37/2085	115/9376	1.4468230632885	SGK1/ARHGEF11/MAFB/ATF2/ADCY7/RAF1/GNAI3/PDE4B/SP1/MAP2K1/ITPR2/ATF6B/ARRB1/MAPK1/BRAF/MEF2A/EGR1/OXSR1/HBEGF/PRKCA/VDR/PLCB2/ARRB2/ADCY3/GNA13/PRKCB/FOS/MMP14/ITPR1/CDKN1A/BCL2/RUNX2/GNAQ/CREB5/JUND/PLCB3/CYP27B1	2.57810545888741
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	31/2085	93/9376	1.49896083133493	MAML2/IL2RA/IFNGR1/IFNGR2/HLA-DQB1/NFKBIE/CHUK/PPP3R1/NFKBIA/JAK3/IL4R/MAPK13/STAT6/JAK2/STAT5A/NFKB1/PPP3CC/MAPK1/NOTCH2/JUN/MAML1/HLA-DQA1/DLL1/MAPK9/IKBKB/FOS/NFATC1/MAF/MAPK8/IL12RB1/JAG1	2.58588300820324
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2085	38/9376	1.77508519500189	UGP2/HK2/HK3/GALK2/HEXA/NAGK/GNPDA1/GNPNAT1/GALE/UAP1L1/PGM3/FPGT/PMM2/GNPDA2/HEXB	2.5601147023532
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	127/2085	480/9376	1.1898001598721	TANK/HSPA5/IL6/TBK1/ATP2A2/TNF/C9orf72/DDIT3/XBP1/PSMA3/PPID/PSMD11/PSMA6/IL1B/RAB8A/CASP7/PSMA2/SDHD/IL1A/NRAS/CAMK2D/LRRK2/CASP8/PSEN1/MAP2K3/UBE2J1/SPG11/RAF1/PPP3R1/KRAS/PTGS2/PSMC6/BID/NRBF2/PSMD12/ATXN2L/CYCS/UBE2G1/RAB5A/PSMA1/MAPK13/RAB1A/ATXN1/PPIF/EIF2S1/BCL2L1/DCTN4/FZD5/PSMC2/CASP3/MAP2K1/PIK3C3/SDHB/ITPR2/UBE2G2/PRNP/PSMA5/SMCR8/ERN1/TUBB2A/TARDBP/ACTR10/DVL3/FAS/NDUFB5/TNFRSF1A/CSF1/FUS/NFKB1/PPP3CC/CTNNB1/EIF2AK3/PSMC4/MAPK1/CHMP2B/BAX/WIPI1/BRAF/FZD2/NDUFB3/CSNK1A1/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/SLC25A5/GSK3B/ULK2/CSNK2A1/MT-ND6/ATG2B/VDAC2/MAPK9/CAT/PRKCA/MAP1LC3B/MCU/CSNK1E/SNCA/PLCB2/HTT/PRKCB/ATXN1L/ALS2/ITPR1/CASP9/BCL2/MTOR/ZFYVE1/GNAQ/CHRFAM7A/IFT57/TUBA1B/AXIN1/MFN1/FRAT2/CYBB/SQSTM1/DNAH3/MAPK8/NDUFA7/PLCB3/DNAH14/MAP3K10/MT-ND4L/TUBB1	2.28278454816721
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/2085	63/9376	1.57033991854136	GTF2H2/GTF2H1/CCNH/RAD23B/POLR2K/PCNA/GTF2H3/POLR2B/POLR2M/RPA1/RAD23A/CUL4A/POLD3/GTF2H2C/POLD4/POLR2A/POLR2J3/ERCC6/ERCC8/LIG1/POLE/POLR2J2	2.42887050609492
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2085	32/9376	1.82685851318945	ATG4C/ATG5/PIK3C3/PPP2CA/PPP2CB/ATG7/WIPI1/ULK2/ATG2B/ATG3/MTOR/RPTOR/ATG16L1	2.50544512531906
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	46/2085	154/9376	1.34322464106637	GCH1/KYNU/KMO/MAT2A/ALAS1/UGP2/CMPK2/MTHFD2/GCLM/NADK/PANK3/MAT2B/AK6/PDXK/BCAT1/PNPO/COQ2/MTHFD2L/RFK/MOCS2/RDH11/ALDH3A2/CMPK1/MTHFD1L/DLD/FPGS/TPK1/COX15/PTS/ADSL/GGCX/COX10/CPOX/NADSYN1/NME7/NADK2/COQ5/SHMT1/GPHN/COQ7/EARS2/CTPS1/PMM2/FECH/NQO1/IDO1	2.2965260693398
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	42/2085	139/9376	1.35877024998706	HSPA1B/HSPA1A/FKBP4/HSP90AA1/HSPA6/HSPA8/ATF2/PRKCD/NRAS/ADCY7/GRB2/FKBP5/RAF1/GNAI3/KRAS/SP1/HSP90AB1/MAP2K1/ITPR2/PIK3CB/SOS2/ATF6B/NCOA2/SOS1/MAPK1/HSP90B1/AKT1/JUN/NCOA3/HBEGF/PLCB2/ADCY3/TGFA/PIK3CA/FOS/ITPR1/BCL2/GNAQ/CREB5/KCNJ5/PLCB3/POMC	2.27878562020921
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	37/2085	122/9376	1.36380862523096	ATF2/NRAS/SOCS3/MAP3K1/ADCY7/MAP2K3/GRB2/RAF1/GNAI3/KRAS/SOCS1/STAT3/MAPK13/MAP2K1/ITPR2/PIK3CB/SOS2/JAK2/ATF6B/STAT5A/SOS1/MAPK1/AKT1/GSK3B/MAPK9/PRKCA/PLCB2/ADCY3/PRKCB/PIK3CA/FOS/ITPR1/MTOR/GNAQ/CREB5/MAPK8/PLCB3	2.16288424762561
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	14/2085	37/9376	1.70152310583965	UGP2/HK2/HK3/GALK2/NANS/TGDS/NAGK/GNPNAT1/GALE/UAP1L1/PGM3/FPGT/NANP/PMM2	2.2863239875765
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	14/2085	37/9376	1.70152310583965	IL18/IL6/TNF/IL1B/ICAM1/IL10/MYD88/FAS/PRKCA/PLCB2/PRKCB/GNAQ/PLCB3/IDO1	2.2863239875765
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/2085	44/9376	1.63522999781993	MGAT4A/MAN1A1/MGAT2/ALG13/OSTC/STT3B/RPN1/B4GALT1/ALG2/HEXA/MGAT1/MAN1C1/ALG1/ALG11/HEXB/ALG9	2.25847397665417
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	103/2085	388/9376	1.19376004351158	ADAM17/IL6/SLC11A2/ATP2A2/TNF/DDIT3/XBP1/PSMA3/PPID/PSMD11/PSMA6/IL1B/CASP7/PSMA2/SDHD/IL1A/NRAS/CHUK/SLC39A8/CASP8/PSEN1/RAF1/PPP3R1/KRAS/PTGS2/PSMC6/BID/NRBF2/PSMD12/CYCS/PSMA1/PPIF/EIF2S1/FZD5/PSMC2/CASP3/MAP2K1/NCSTN/PIK3C3/SDHB/ITPR2/PIK3CB/PSMA5/SLC39A11/ERN1/TUBB2A/DVL3/FAS/NDUFB5/TNFRSF1A/CSF1/NFKB1/PPP3CC/CTNNB1/EIF2AK3/PSMC4/MAPK1/WIPI1/BRAF/FZD2/NDUFB3/AKT1/ADAM10/IDE/CSNK1A1/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/SLC25A5/GSK3B/ULK2/CSNK2A1/RTN3/MT-ND6/ATG2B/VDAC2/MAPK9/IKBKB/MCU/CSNK1E/APOE/SNCA/PLCB2/EIF2AK2/PIK3CA/ITPR1/CASP9/MTOR/GNAQ/CHRFAM7A/TUBA1B/AXIN1/LRP1/FRAT2/CYBB/MAPK8/RTN4/NDUFA7/PLCB3/MT-ND4L/TUBB1	2.08446051544101
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	15/2085	41/9376	1.64520091244078	NBN/ATM/RPA1/MRE11/POLD3/UIMC1/TOPBP1/POLD4/PALB2/RAD50/RAD51B/RAD51D/RAD52/TOP3A/MUS81	2.21398594153565
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	14/2085	38/9376	1.65674618200177	NAMPT/NT5C2/NADK/SIRT1/NNT/PNP/SIRT6/BST1/CD38/SIRT7/NADSYN1/NADK2/SIRT5/NT5DC4	2.16923967468241
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/2085	67/9376	1.47658828161352	NRAS/CAMK2D/RAF1/PPP3R1/KRAS/PPP1R1A/RAP1A/MAP2K1/PPP1CC/ITPR2/PPP1CB/PPP3CC/MAPK1/BRAF/RPS6KA1/PRKCA/PLCB2/PRKCB/ITPR1/GNAQ/RAP1B/PLCB3	2.09350674570028
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/2085	56/9376	1.52572798903734	MGAT4A/MAN1A1/MGAT2/ALG13/OSTC/STT3B/RPN1/B4GALT1/ALG2/DPM1/MGAT5/MGAT1/ST6GAL1/ALG5/MAN1C1/ALG1/ALG6/ALG11/ALG9	2.1100477088247
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	26/2085	82/9376	1.42584079078201	HSPA1B/HSPA5/HSPA1A/CTSL/TNF/CALR/HSP90AA1/IFI30/HSPA6/HLA-DQB1/HSPA8/HSPA4/HLA-F/TAP1/CTSB/HSP90AB1/CTSS/RFX5/LGMN/NFYB/NFYA/HLA-DQA1/NFYC/CANX/PDIA3/TAP2	2.07108522527294
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	8/2085	18/9376	1.99861444177991	LMBRD1/ZNF143/MMADHC/ABCD4/MTRR/PRDX1/ZNF76/MMAA	2.26771093009086
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	57/2085	204/9376	1.25648187332487	PLAU/VAV3/CTSL/TNF/TLR2/SDC4/PLAUR/TLR4/HIF1A/HPSE/NRAS/CAMK2D/ITGAV/MDM2/GRB2/CCND1/RAF1/KRAS/DDX5/CD44/SDC2/STAT3/MAPK13/FZD5/CASP3/MAP2K1/PPP1CC/ITPR2/PIK3CB/VAV1/SOS2/PPP1CB/FAS/ARHGEF12/SOS1/HCLS1/CTNNB1/CDC42/MAPK1/SMAD2/BRAF/FZD2/AKT1/HBEGF/PRKCA/PRKCB/PIK3CA/SLC9A1/ITPR1/CDKN1A/MTOR/RPS6KB1/ELK1/PPP1R12B/MYC/MSN/TGFB2	1.98054564772115
Organismal Systems	Nervous system	hsa04730	Long-term depression	20/2085	60/9376	1.49896083133493	NRAS/RAF1/GNAI3/KRAS/MAP2K1/ITPR2/PPP2CA/PPP2CB/PLA2G4A/PLA2G4C/MAPK1/BRAF/LYN/PRKCA/PLCB2/GNA13/PRKCB/ITPR1/GNAQ/PLCB3	2.07334922451617
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	43/2085	149/9376	1.29775803518259	CXCL8/LPAR6/CYTH1/NRAS/ADCY7/DNM2/GRB2/RAF1/KRAS/PDGFB/ARF6/MAP2K1/PIK3CB/RHEB/RALB/LPAR5/SOS2/PLA2G4A/PIK3CG/SOS1/CYTH4/PLA2G4C/MAPK1/AKT1/RALGDS/AGPAT3/PTK2B/PRKCA/TSC1/PLCB2/FCER1G/ADCY3/GNA13/PIK3CA/ARF1/DGKG/MTOR/DGKD/DGKE/PLCB3/DGKQ/DGKH/LPAR2	1.95916711586579
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	33/2085	110/9376	1.34906474820144	TNF/ZFYVE16/SMURF2/ACVR1B/ID2/TGIF1/SP1/CUL1/E2F4/SKIL/SMAD4/NRROS/PPP2CA/TGFBR2/PPP2CB/MAPK1/SMAD2/LEMD3/ACVR1/CDKN2B/SIN3A/SMAD7/ID3/RPS6KB1/HAMP/MYC/SKP1/SMURF1/TGIF2/TGFB2/ACVR2A/TF/RGMB	1.969252045824
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/2085	158/9376	1.28075767234314	RB1/CCNH/MDM2/CCND1/ESCO1/CUL1/E2F4/SMAD4/WAPL/PCNA/YWHAG/ATR/STAG1/PPP2CA/CDC27/ATM/E2F3/PPP2CB/CDC26/GADD45A/ANAPC10/ANAPC7/CDKN1B/SMAD2/CDKN2B/PPP2R5C/HDAC8/GSK3B/BUB3/ZBTB17/YWHAH/ANAPC4/CDKN1A/CDKN2A/MYC/MAD2L1BP/SKP1/TGFB2/ANAPC1/ORC6/DBF4B/FBXO5/WEE1/CHEK1/CDK2	1.90321101915571
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	40/2085	140/9376	1.28482356971566	KLF2/NRAS/ADCY7/CCND1/RAF1/GNAI3/KRAS/SLC8A1/GNB4/GNG10/TFAM/MAP2K1/PIK3C3/SMAD4/ITPR2/PIK3CG/MAPK1/SMAD2/AKT1/MEF2A/EGR1/PRKAA1/PRKAG2/MAP1LC3B/PLCB2/ADCY3/GNA13/PRKAB1/GNGT2/SLC9A1/ITPR1/MTOR/RPS6KB1/GNG5/GNAQ/HDAC4/PLCB3/JAG1/NRF1/PRKAB2	1.81569584453915
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	34/2085	117/9376	1.30678636577917	CDK2AP2/GATAD2A/SMARCE1/ING3/MORF4L2/RBBP4/ARID2/BAZ1A/PBRM1/BRD7/ARID1B/ACTL6A/DPF2/EPC1/PHF6/UCHL5/INO80D/MBD2/INO80/EPC2/BCL7B/EP400/ACTR8/VPS72/SS18L1/MRGBP/MCRS1/INO80C/BICRAL/MTA2/BICRA/MTA1/ACTR5/INO80B	1.78563241970513
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/2085	23/9376	1.75964967156709	PCNA/MLH1/MSH6/RPA1/POLD3/POLD4/MLH3/PMS2/LIG1	1.95050435347238
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	17/2085	52/9376	1.47013466150157	ABCA1/APOC1/STARD3NL/MYLIP/NPC1/NCEH1/ANGPTL4/VAPA/VDAC1/STARD3/SORT1/VDAC2/LIPA/APOE/LRP1/LDLRAP1/LDLR	1.81789137703248
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	23/2085	75/9376	1.37904396482814	HSPA5/PDIA4/ATF2/ADCY7/GSR/ITPR2/ATP1A1/ATF6B/HSP90B1/CANX/PRKCA/PLCB2/TTF1/ADCY3/TTF2/ATP1B1/PRKCB/PAX8/ITPR1/GNAQ/FXYD2/CREB5/PLCB3	1.76238389055873
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	43/2085	154/9376	1.2556230340403	TRPM2/NRAS/CAMK2D/ADCY7/CCND1/RAF1/GNAI3/PPP3R1/KRAS/PTGS2/MAP2K1/PPP1CC/ITPR2/PPP1CB/PLA2G4A/PIK3CG/PPP3CC/PLA2G4C/MAPK1/JUN/RCAN1/PRKAA1/KCNJ2/CD38/PRKCA/PRKAG2/PLCB2/ADCY3/PRKAB1/MAPK7/PRKCB/FOS/NFATC1/ITPR1/CDKN1A/EEF2K/ELK1/GNAQ/KCNJ5/PPP1R12B/PLCB3/RGS2/PRKAB2	1.71038116544718
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/2085	56/9376	1.44542651593011	SMURF2/CCND1/SPOPL/CUL1/CSNK1G3/ARRB1/CUL3/CSNK1D/CSNK1A1/GRK3/GSK3B/BTRC/CSNK1E/ARRB2/BCL2/SMURF1/HHAT/PTCH2	1.78775187737122
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	15/2085	45/9376	1.49896083133493	ABCG1/ABCA1/TAP1/ABCC3/ABCA5/ABCC5/ABCC1/ABCD4/ABCC10/TAP2/ABCD3/ABCB4/DEFB1/ABCB10/ABCG2	1.79412928681752
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	43/2085	155/9376	1.2475222402723	RB1/AHR/ATF2/CAMK2D/ADCY7/CCND1/GNAI3/RAP1A/SP1/FZD5/MAP2K1/NCEH1/ITPR2/E2F3/DVL3/PDE8A/ATF6B/RBBP5/CTNNB1/CDKN1B/ARNT/MAPK1/BRAF/FH/FZD2/CDKN2B/GSK3B/PLCB2/ADCY3/ITPR1/KMT2D/CDKN1A/CDKN2A/GNAQ/CREB5/RAP1B/AXIN1/PLCB3/TCF7/NR4A1/POMC/LDLR/CDK2	1.66163711377641
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/2085	57/9376	1.42006815600151	ACSL1/SCD/ACSL3/ELOVL5/ACSL4/ACAT2/HSD17B4/SCP2/ACOX1/HADHB/ACADM/ACADVL/ACSL5/HSD17B12/ACACA/ELOVL7/CBR4/EHHADH	1.70105223947707
Organismal Systems	Digestive system	hsa04978	Mineral absorption	19/2085	61/9376	1.40066831780477	SLC11A2/TRPM7/SLC8A1/SLC31A1/ATP1A1/MT1X/MT1F/HMOX1/SLC30A1/ATP7A/MT1G/VDR/ATP1B1/FXYD2/ATP2B1/MT1H/FTL/TF/SLC26A6	1.67881797020211
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	30/2085	104/9376	1.29717764250138	ETNK1/GPCPD1/GPD2/SGMS1/LPGAT1/CDS2/LPCAT2/CHPT1/LPCAT3/CEPT1/PLA2G4A/LYPLA2/PLA2G4C/CRLS1/ACHE/AGPAT3/CHKA/PGS1/SELENOI/DGKG/DGKD/LPCAT4/SGMS2/PLA1A/CDS1/DGKE/LPIN3/DGKQ/DGKH/CHKB	1.62963825152763
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/2085	116/9376	1.27928553708757	ME2/IDH1/ADPGK/HK2/SDHD/HK3/ACAT2/RPE/ACOX1/HIBCH/ACO1/PRPS1/DLAT/SDSL/SDHB/MDH1/SDS/ME1/IDH3A/ALDOA/SUCLA2/PGP/FH/GLUD1/DLD/CAT/ACSS2/TALDO1/PCCA/SHMT1/GOT1/RPIA/GPT2	1.61851625774293
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/2085	50/9376	1.43900239808153	IL18/CXCL8/IL6/TNF/TLR2/IL1B/TLR4/CCL2/ICAM1/CD40/IL10/MYD88/CR1/SDC2/LRP1/TGFB2	1.66436781117187
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/2085	28/9376	1.60602946214457	ATP6V1C1/ATP6V1B2/ATP6V1A/ATP6V0A1/ATP6V1D/SLC12A7/CA2/ATP6V1G1/ATP6V1E2/ATP6V0D2	1.71734883759598
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/2085	21/9376	1.71309809295421	DPYD/PANK3/BCAT1/AASDHPPT/CSAD/ALDH3A2/VNN1/VNN2	1.74937189590768
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	37/2085	133/9376	1.25101242314419	VAV3/TNF/LCP2/IFNGR1/IFNGR2/ICAM1/NRAS/LAT2/GRB2/RAF1/FCGR3A/TNFRSF10B/PPP3R1/KRAS/BID/TNFRSF10A/CD48/SH3BP2/CASP3/MAP2K1/MICB/PIK3CB/VAV1/SOS2/FAS/SOS1/PPP3CC/MAPK1/BRAF/PTK2B/PRKCA/FCER1G/PRKCB/PIK3CA/NFATC1/MICA/FCGR3B	1.55904869076019
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2085	32/9376	1.54580335731415	ACOX1/HIBCH/ECHDC1/SUCLA2/DLD/ACSS2/ACACA/MLYCD/PCCA/BCKDHB/EHHADH	1.65382630662012
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	41/2085	150/9376	1.22914788169464	RB1/NRAS/GRB2/CCND1/RAF1/POLK/KRAS/FZD5/MAP2K1/SMAD4/PIK3CB/SOS2/E2F3/MLH1/TGFBR2/DVL3/GADD45A/SOS1/CTNNB1/CDKN1B/MAPK1/BAX/SMAD2/BRAF/FZD2/AKT1/CSNK1A1/CDKN2B/GSK3B/CTNNA1/PIK3CA/CDKN1A/BCL2/MTOR/RPS6KB1/AXIN1/FRAT2/MYC/TGFB2/TCF7/CDK2	1.51286393530969
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	85/2085	333/9376	1.14785288886008	PTGER4/MAML2/TBK1/TNF/ATP6V1C1/RB1/MX1/NRAS/OASL/HLA-F/PTEN/CHUK/ITGAV/CASP8/PSEN1/MDM2/GRB2/CCND1/PPP2R2A/RAF1/KRAS/ATP6V1H/PTGS2/ATP6V1B2/TRAF3/STAT2/ATP6V1A/FZD5/ATP6V0A1/CASP3/MAP2K1/ATP6V1D/ATR/UBE3A/IRF1/PIK3CB/RHEB/PPP2CA/IKBKE/SOS2/ATM/PPP2CB/DVL3/FAS/TNFRSF1A/SOS1/NFKB1/CTNNB1/CDKN1B/CDC42/MAPK1/BAX/FZD2/NOTCH2/AKT1/PPP2R2D/CSNK1A1/IRF9/MAML1/PPP2R5C/PPP2R3C/GSK3B/TLR3/HES4/DLG1/IKBKB/TBP/TSC1/ATP6V1G1/EIF2AK2/TBPL1/PIK3CA/MX2/CDKN1A/TICAM1/MTOR/RPS6KB1/CREB5/ATP6V1E2/AXIN1/ATP6V0D2/TCF7/JAG1/CDK2/ITGA10	1.46906423095289
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	36/2085	130/9376	1.24529053680133	ATF2/NRAS/ADCY7/GRB2/RAF1/GNAI3/KRAS/NFKBIA/GNB4/GNG10/MAPK13/GNA15/MAP2K1/PIK3CB/SOS2/TGFBR2/ATF6B/ARRB1/SOS1/NFKB1/MAPK1/SMAD2/AKT1/JUN/MAPK9/PRKCA/PLCB2/ARRB2/ADCY3/PIK3CA/GNGT2/FOS/GNG5/CREB5/MAPK8/PLCB3	1.50598499230955
Organismal Systems	Immune system	hsa04611	Platelet activation	35/2085	126/9376	1.24913402611244	FCGR2A/LCP2/SNAP23/ADCY7/GNAI3/FERMT3/BTK/RAP1A/VASP/APBB1IP/MAPK13/PPP1CC/ITPR2/PIK3CB/PPP1CB/P2RY1/PLA2G4A/PIK3CG/ARHGEF12/PLA2G4C/MAPK1/AKT1/LYN/PTGIR/PTGS1/PLCB2/FCER1G/ADCY3/GNA13/PIK3CA/ITPR1/GNAQ/RAP1B/MYL12A/PLCB3	1.50554094574427
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/2085	51/9376	1.41078666478582	ATP6V1C1/PDIA4/ATP6V1H/ATP6V1B2/ATP6V1A/ATP6V0A1/ERO1A/ATP6V1D/SEC61B/KDELR2/PRKCA/ATP6V1G1/ADCY3/ARF1/ATP6V1E2/ATP6V0D2	1.57297609787238
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/2085	55/9376	1.38994549814694	UGCG/CERS2/SGMS1/SGPP1/SPTLC1/ACER3/GLA/B4GALT5/NEU3/NEU1/GALC/DEGS1/HEXA/ASAH1/NEU4/SGMS2/HEXB	1.55095472551047
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	21/2085	71/9376	1.33006383625494	GLS/IDH1/HK2/HIF1A/NRAS/PTEN/HK3/TIGAR/RAF1/KRAS/MAP2K1/PDK1/PIK3CB/SIRT6/MAPK1/AKT1/PIK3CA/SLC7A5/MTOR/MYC/NTRK3	1.49284269539446
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/2085	44/9376	1.43082624809243	MBD4/PCNA/PARG/POLB/POLG2/POLD3/APTX/POLG/PARP4/PNKP/POLD4/PARP2/LIG1/POLE	1.53174420779188
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	40/2085	148/9376	1.21537364702832	RB1/NRAS/PTEN/GRB2/CCND1/RAF1/POLK/KRAS/SP1/FZD5/MAP2K1/PIK3CB/SOS2/E2F3/DVL3/GADD45A/SOS1/CTNNB1/NFKB2/MAPK1/BAX/BRAF/FZD2/NOTCH2/AKT1/CSNK1A1/JUN/GSK3B/NCOA3/DLL1/PIK3CA/FOS/CDKN1A/MTOR/RPS6KB1/AXIN1/FRAT2/MYC/TCF7/JAG1	1.41226028341506
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/2085	60/9376	1.34906474820144	NRAS/RAF1/PPP3R1/KRAS/PTGS2/MAPK13/MAP2K1/PIK3CB/PLA2G4A/PPP3CC/CDC42/PLA2G4C/MAPK1/AKT1/PRKCA/PRKCB/PIK3CA/CASP9	1.45048083845197
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2085	12/9376	1.87370103916867	COQ2/GGCX/COQ5/COQ7/NQO1	1.61945129637767
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/2085	12/9376	1.87370103916867	FCGR2B/NPC1/NECTIN4/CD209/SLAMF1	1.61945129637767
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/2085	30/9376	1.49896083133493	IDH1/SDHD/ACO1/DLAT/SDHB/MDH1/IDH3A/SUCLA2/FH/DLD	1.46372439963658
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/2085	65/9376	1.3144733444014	NRAS/RAF1/KRAS/MAP2K1/ITPR2/PIK3CB/ARRB1/MAPK1/AKT1/PRKCA/PLCB2/ARRB2/PRKCB/PIK3CA/ITPR1/GNAQ/KCNJ5/KCNN4/PLCB3	1.36046531242798
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	25/2085	89/9376	1.26316923988899	NRAS/ADCY7/GRB2/RAF1/GNAI3/KRAS/PDGFB/MAP2K1/ITPR2/SOS2/TUBB2A/SOS1/MAPK1/CSNK1D/MAP3K2/PRKCA/PLCB2/ADCY3/MAPK7/PRKCB/ITPR1/GNAQ/TUBA1B/PLCB3/TUBB1	1.33394377713179
Human Diseases	Cancer: specific types	hsa05218	Melanoma	21/2085	73/9376	1.29362373115206	RB1/NRAS/PTEN/MDM2/CCND1/RAF1/POLK/KRAS/PDGFB/MAP2K1/PIK3CB/E2F3/GADD45A/MAPK1/BAX/BRAF/AKT1/MITF/PIK3CA/CDKN1A/CDKN2A	1.3467475413894
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	56/2085	217/9376	1.16048580490446	HSP90AA1/RB1/AHR/PTGES3/ATF2/NRAS/ADCY7/GRB2/CCND1/RAF1/GNAI3/KRAS/KLF4/BCL6/STAT3/HSP90AB1/MAP2K1/PIK3CB/KPNA4/IKBKE/SOS2/JAK2/ADRB2/ATF6B/ARRB1/STAT5A/SOS1/NFKB1/ARNT/MAPK1/HSP90B1/NOTCH2/AKT1/XIAP/JUN/GSTO1/DLL1/RPS6KA1/PRKCA/VDR/ARRB2/KPNA2/ADCY3/PRKCB/PIK3CA/FOS/BCL2/MTOR/RPS6KB1/KPNA5/CHRFAM7A/CREB5/PAQR8/MYC/PAQR5/JAG1	1.27905017336376
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/2085	23/9376	1.56413304139297	NUS1/HMGCS1/ACAT2/IDI1/ZMPSTE24/DHDDS/HMGCR/PDSS1	1.44848868413869
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	30/2085	110/9376	1.22642249836494	HSP90AA1/STK10/ADCY7/RAF1/GNAI3/KRAS/HSP90AB1/MAPK13/CPEB2/MAP2K1/PIK3CB/CDC27/CDC26/ANAPC10/ANAPC7/MAPK1/BRAF/AKT1/RPS6KA1/MAPK9/CPEB3/ADCY3/PIK3CA/ANAPC4/CPEB4/MAPK8/ANAPC1/SPDYA/AURKA/CDK2	1.27736464487797
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/2085	46/9376	1.36861641121885	PSMA3/PSMD11/PSMA6/PSMA2/PSME4/PSMC6/PSMD12/PSMA1/PSMC2/PSMA5/PSMC4/PSMD6/PSMD9/PSMB9	1.34016378932156
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/2085	54/9376	1.33240962785327	POLK/ATR/MLH1/RPA1/REV1/PALB2/PMS2/RMI1/FANCL/POLI/UBE2T/FAN1/TOP3A/MUS81/FANCF/FANCG	1.30996907581835
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/2085	31/9376	1.45060725613058	GLUL/ACAT2/ACO1/MDH1/PGP/DLD/CAT/ACSS2/PCCA/SHMT1	1.34379955732054
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	38/2085	144/9376	1.18667732480682	ACVR1B/NRAS/GRB2/RAF1/ID2/KRAS/KLF4/JAK3/JARID2/PCGF5/STAT3/MAPK13/SMARCAD1/FZD5/MAP2K1/SKIL/SMAD4/PIK3CB/JAK2/DVL3/CTNNB1/MAPK1/SMAD2/FZD2/BMI1/AKT1/ACVR1/PCGF3/GSK3B/HESX1/SETDB1/ID3/PIK3CA/AXIN1/MYC/LIF/TCF7/ACVR2A	1.20717445133518
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2085	20/9376	1.57390887290168	NPL/UGP2/CYB5R4/NANS/TGDS/UAP1L1/NANP	1.37390893907967
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	28/2085	103/9376	1.22245349351587	CXCL8/IL6/TNF/TLR2/IL1B/TLR4/SERPINB9/IL10/RAB5A/GNA15/CASP3/CXCL1/PIK3CB/RAB7A/RAB5B/NFKB1/ACTN1/ITGAM/PRKCA/CXCL3/PLCB2/PRKCB/PIK3CA/GNAQ/PRDX1/CXCL2/PLCB3/TGFB2	1.21392772858015
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/2085	99/9376	1.22642249836494	PTGER4/IL1B/PRKCD/CAMK2D/ADCY7/MAP2K3/IL1RAP/MAPK13/PPP1CC/ITPR2/PIK3CB/PPP1CB/PLA2G4A/TRPV4/PLA2G4C/MAPK9/PRKCA/PLCB2/ADCY3/PRKCB/PIK3CA/PTGER2/ITPR1/GNAQ/MAPK8/PLCB3/TRPV3	1.21109584973864
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	69/2085	275/9376	1.12830869849575	HSPA1B/HSPA5/HSPA1A/IL6/STIP1/TNF/DDIT3/PSMA3/PSMD11/PSMA6/IL1B/HSPA6/PSMA2/HSPA8/ATF2/PRKCD/SDHD/IL1A/PPP3R1/PSMC6/PSMD12/CYCS/PSMA1/MAPK13/PPIF/EIF2S1/PSMC2/CASP3/SDHB/ITPR2/PIK3CB/PRNP/PSMA5/TUBB2A/NCF2/NDUFB5/NCF4/ATF6B/NCF1/PPP3CC/EIF2AK3/PSMC4/MAPK1/BAX/NDUFB3/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/EGR1/C1QC/SLC25A5/GSK3B/CSNK2A1/MT-ND6/VDAC2/MAPK9/MCU/PIK3CA/ITPR1/CASP9/CREB5/TUBA1B/CYBB/MAPK8/NDUFA7/MT-ND4L/TUBB1	1.1548431646994
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	46/2085	178/9376	1.16211570069787	CACYBP/SIAH1/CAMK2D/TBL1XR1/PSEN1/CCND1/PPP3R1/SIRT1/PPARD/CUL1/FZD5/SMAD4/MAP3K7/DVL3/TLE4/NLK/RYK/PPP3CC/CTNNB1/FZD2/CSNK1A1/JUN/GSK3B/CSNK2A1/BTRC/INVS/MAPK9/PRKCA/CSNK1E/CTNNBIP1/PLCB2/LZTS2/PRKCB/NFATC1/SENP2/FOSL1/CCAR2/AXIN1/FRAT2/MYC/MAPK8/GPC4/SKP1/PLCB3/TCF7/VANGL1	1.16770595504849
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/2085	13/9376	1.72957019000184	XRCC4/LIG4/DCLRE1C/MRE11/RAD50	1.40759061889806
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	14/2085	47/9376	1.33949691310781	TNF/HK2/PRKCD/HK3/SOCS3/SOCS1/SOCS4/PIK3CB/MAPK1/MAPK9/IKBKB/PIK3CA/MTOR/MAPK8	1.24770619369996
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2085	24/9376	1.49896083133493	HS3ST3B1/HS2ST1/HS3ST1/HS3ST2/GLCE/EXT1/NDST2/HS3ST3A1	1.30877486308043
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/2085	59/9376	1.29571190505223	DPYD/CMPK2/NT5C2/NT5C3A/ENTPD1/DCK/UPP1/RRM2B/DCTPP1/CMPK1/DCTD/ENTPD4/CDADC1/NME7/UCKL1/CTPS1/NT5DC4	1.21843365377288
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	44/2085	170/9376	1.1638989984483	RAB8A/RUNX1/ARHGEF2/RAPGEF2/HSPA4/RAP2C/RAB8B/NEDD4L/ACTR3/MAP3K1/CCND1/PPP2R2A/RAP1A/VASP/WHAMM/PCNA/PPP2CA/PPP2CB/ACTR2/F11R/HCLS1/ACTN1/CDC42/ARPC1A/PPP2R2D/JUN/SYMPK/PRKAA1/DLG1/MAPK9/ARHGAP17/PRKAG2/ARPC1B/PRKAB1/CLDN23/TJAP1/YBX3/ARPC3/MYL12A/TUBA1B/MSN/OCLN/MAPK8/PRKAB2	1.15321529520905
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/2085	116/9376	1.20175308029439	VAV3/ICAM1/GNAI3/RAP1A/VASP/MAPK13/CTNND1/PIK3CB/VAV1/NCF2/NCF4/F11R/NCF1/CTNNB1/ACTN1/CDC42/PTK2B/RASSF5/CTNNA1/ITGAM/PRKCA/PRKCB/CLDN23/PIK3CA/CXCL12/RAP1B/MYL12A/CYBB/MSN/OCLN/RHOH	1.16919996613999
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	35/2085	133/9376	1.18339013000126	ATF2/CAMK2D/PPP2R2A/GNAI3/GNB4/GNG10/MAPK13/COMT/PPP1CC/ITPR2/PPP2CA/PPP1CB/PPP2CB/ATF6B/ARRB1/PPP3CC/AKT1/PPP2R2D/PPP2R5C/PPP2R3C/GSK3B/MAPK9/PRKCA/PLCB2/ARRB2/PRKCB/GNGT2/FOS/ITPR1/GNG5/GNAQ/CREB5/KCNJ5/MAPK8/PLCB3	1.13904379112172
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/2085	17/9376	1.58713499788405	PAPSS1/SEPHS2/TXNRD1/SEPSECS/SCLY/PSTK	1.29566528956075
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2085	10/9376	1.79875299760192	PAPSS1/SQOR/BPNT1/SUOX	1.35138950870454
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2085	14/9376	1.60602946214457	B3GNT2/B3GNT7/B4GALT1/B4GALT4/ST3GAL1	1.21344069604324
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	30/2085	115/9376	1.17309978104473	NRAS/CAMK2D/ADCY7/GNAI3/KRAS/GNB4/GNG10/MAP2K1/ITPR2/PIK3CB/JAK2/PIK3CG/MAPK1/AKT1/ACHE/KCNJ2/PRKCA/PLCB2/ADCY3/PRKCB/PIK3CA/GNGT2/FOS/ITPR1/BCL2/GNG5/GNAQ/CHRFAM7A/CREB5/PLCB3	0.998761091603478
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2085	18/9376	1.49896083133493	ACSL1/ACSL3/ACSL4/ACSL5/ACACA/CBR4	1.13306886378359
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/2085	70/9376	1.22058239122987	CD80/HLA-DQB1/ICAM1/ABL2/HLA-F/CD40/CASP8/CCND1/BID/CYCS/CD55/CASP3/SNTB1/EIF4G2/EIF4G3/EIF4G1/HLA-DQA1/CASP9/SSPN	0.990566086167974
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	17/2085	62/9376	1.23301616771099	ADAM17/MAML2/DTX2/NUMB/PSEN1/DTX3L/ATXN1/NCSTN/DVL3/TLE4/NOTCH2/MAML1/DLL1/KAT2B/ATXN1L/KAT2A/JAG1	0.984371207058706
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	11/2085	38/9376	1.30172914300139	SGK1/NEDD4L/KRAS/PIK3CB/ATP1A1/MAPK1/PRKCA/ATP1B1/PRKCB/PIK3CA/FXYD2	0.996614591670017
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	58/2085	238/9376	1.09587892711041	ADAM17/CXCL8/IL6/TBK1/CASP1/FCGR2A/TNF/TLR2/IL1B/CGAS/TLR4/NLRP3/CCL2/MX1/IRAK1/OAS2/CHUK/TAB2/NFKBIA/TRAF3/MYD88/STAT2/OAS1/STAT3/MAPK13/RPL22L1/MAP3K7/PIK3CB/TRAF6/IKBKE/RPS10/NRP1/TNFRSF1A/C3AR1/NFKB1/ADAR/MAPK1/IFIH1/IRAK4/IRF9/JUN/C1QC/TLR3/HBEGF/MAPK9/CXCL10/IKBKB/RPL17/PRKCA/PRKCB/EIF2AK2/PIK3CA/FOS/MX2/IL6R/TLR8/CYBB/MAPK8	0.801182004607518
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/2085	43/9376	1.25494395181529	ACSL1/ACSL3/ACSL4/ACAT2/ACOX1/HADHB/ACADM/ACADVL/ALDH3A2/ACSL5/ECI2/EHHADH	0.896011176700515
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7/2085	23/9376	1.36861641121885	GLS/MDH1/ATP1A1/GLUD1/CA2/ATP1B1/FXYD2	0.946473014804996
NA	NA	hsa04981	Folate transport and metabolism	9/2085	31/9376	1.30554653051752	MTHFS/ABCC3/ABCC5/ABCC1/FPGS/SLCO2B1/SHMT1/ABCG2/SLC19A1	0.911199912704662
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2085	27/9376	1.33240962785327	SCD/ELOVL5/HSD17B4/SCP2/ACOX1/HSD17B12/ELOVL7/ACOT2	0.924949485278736
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/2085	85/9376	1.1638989984483	AMPD3/CMPK2/NT5C2/LACC1/NT5C3A/ENTPD1/DCK/UPP1/AK6/RRM2B/GMPR/DCTPP1/PNP/HPRT1/CMPK1/DCTD/ENTPD4/ADSL/NME7/UCKL1/CTPS1/NT5DC4	0.811707672851623
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	41/2085	166/9376	1.11067579671203	ATP2A2/KCNMA1/ATF2/ADCY7/RAF1/GNAI3/PPP3R1/SLC8A1/VASP/PPIF/MAP2K1/ADORA3/PPP1CC/ITPR2/ATP1A1/PPP1CB/PIK3CG/ADRB2/ATF6B/PPP3CC/MAPK1/AKT1/MEF2A/VDAC1/SLC25A5/KCNMB1/VDAC2/PLCB2/ADCY3/GNA13/ATP1B1/NFATC1/ITPR1/GTF2I/GNAQ/FXYD2/CREB5/ADRA2B/ATP2B1/PLCB3/RGS2	0.76934653942382
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/2085	48/9376	1.21790567545963	HMGCS1/ACAT2/HIBCH/HADHB/BCAT1/ACADM/ALDH3A2/AACS/DLD/HIBADH/PCCA/BCKDHB/EHHADH	0.809356782534418
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/2085	36/9376	1.24913402611244	PCNA/RNASEH2B/RPA1/POLD3/POLD4/PRIM2/POLA2/POLA1/LIG1/POLE	0.80085884685514
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/2085	28/9376	1.28482356971566	B3GNT5/ST3GAL6/FUT4/GCNT2/B3GNT2/B4GALT1/B4GALT4/B3GALNT1	0.807124829608422
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2085	16/9376	1.4052757793765	GLA/HEXA/ST3GAL1/B3GALNT1/HEXB	0.867596587883664
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	34/2085	138/9376	1.10792757098669	CAMK2D/ADCY7/PPP3R1/MAPK13/CPEB2/CUL1/MAP2K1/YWHAG/PPP1CC/ITPR2/PPP2CA/CDC27/PPP1CB/PPP2CB/CDC26/ANAPC10/ANAPC7/PPP3CC/MAPK1/PPP2R5C/RPS6KA1/BTRC/CPEB3/YWHAH/ADCY3/ANAPC4/ITPR1/CPEB4/SKP1/ANAPC1/SPDYA/FBXO5/AURKA/CDK2	0.683011609922701
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/2085	33/9376	1.22642249836494	IDH1/ACO1/DLAT/BCAT1/IDH3A/DLD/BCKDHB/GOT1/GPT2	0.696752430548633
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	38/2085	157/9376	1.0884174189311	MOB1B/SAV1/MOB1A/TP53BP2/BIRC2/CCND1/PPP2R2A/ID2/LIMD1/FZD5/SMAD4/YWHAG/PPP1CC/PPP2CA/PPP1CB/LATS1/TGFBR2/PPP2CB/DVL3/CTNNB1/CSNK1D/SMAD2/FZD2/PPP2R2D/STK3/GSK3B/BTRC/CTNNA1/DLG1/SMAD7/CSNK1E/BBC3/YWHAH/AXIN1/MYC/TGFB2/TCF7/BIRC3	0.597435287124112
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/2085	54/9376	1.16585842437161	MAT2A/AMD1/GCLM/LACC1/APIP/ENOPH1/MAT2B/SDSL/SMS/DNMT3A/BCAT1/MDH1/SDS/GOT1	0.653619476348844
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/2085	29/9376	1.24051930869098	MOB1B/SAV1/MOB1A/LIMD1/LATS1/STK3/RASSF4/CSNK1E	0.693678035435853
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2085	17/9376	1.3226124982367	GLUL/GLUD1/CA2/CA5B/CA13	0.711927950897464
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	19/2085	76/9376	1.1242206235012	ACSL1/PPARG/GK/SCD/ACSL3/NR1H3/ACSL4/PLIN2/HMGCS1/SCP2/PPARD/ACOX1/ACADM/ME1/ANGPTL4/ACSL5/OLR1/FABP5/EHHADH	0.581438982158773
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/2085	128/9376	1.08908872901679	ENPP4/AMPD3/NT5C2/PAPSS1/ADCY7/LACC1/ENTPD1/PDE7A/DCK/PDE4B/AK6/RRM2B/GMPR/PRPS1/NUDT9/PNP/PDE8A/GART/FHIT/PDE6D/HPRT1/ENTPD4/ADCY3/ADSL/NME7/PRUNE1/PDE6G/PDE1B/PDE6A/NT5DC4/PDE9A	0.54268642258323
Genetic Information Processing	Transcription	hsa03040	Spliceosome	57/2085	243/9376	1.05482428871717	HSPA1B/HSPA1A/SRSF7/HNRNPA3/DDX39B/TRA2A/HSPA6/ACIN1/TRA2B/SRSF1/HSPA8/HNRNPC/SRSF6/SRSF5/SRSF2/DDX5/SRSF3/DHX15/EIF4A3/LSM6/RBMXL1/SRSF10/THOC1/SNRPA1/HNRNPU/PPIL1/SRSF9/PRPF3/LSM8/EFTUD2/SNRNP40/AQR/THOC3/LSM5/FUS/BCAS2/PHF5A/PRPF38A/CWC25/U2AF2/RBM22/CDC40/MAGOH/SF3B6/SF3B1/PRPF18/CHERP/USP39/BUD13/ALYREF/PPIH/SF1/NCBP1/THOC6/DHX16/HNRNPA1/PCBP1	0.463035759980052
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/2085	39/9376	1.15304679333456	MAT2A/MTHFS/MTHFD2/MAT2B/MTHFD2L/GART/MTHFD1L/DLD/SHMT1/ALDH1L2	0.512150943890318
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	16/2085	65/9376	1.10692492160118	ATF2/ADCY7/SP1/NCEH1/ITPR2/PDE8A/ATF6B/PLCB2/ADCY3/ITPR1/GNAQ/CREB5/PLCB3/NR4A1/POMC/LDLR	0.462575443872305
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/2085	35/9376	1.15634121274409	HK2/HK3/TIGAR/PFKFB3/ENOSF1/ALDOA/PFKFB4/FPGT/PMM2	0.495514002297956
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	12/2085	48/9376	1.1242206235012	HK2/HK3/PIK3CB/ATP1A1/AKT1/PLCB2/ATP1B1/PRKCB/PIK3CA/SLC2A5/FXYD2/PLCB3	0.461386808532093
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/2085	31/9376	1.16048580490446	DPYD/CNDP2/ACOX1/HIBCH/CSAD/ALDH3A2/MLYCD/EHHADH	0.478600268088787
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	71/2085	308/9376	1.03661901647513	SOD2/SLC1A3/PPARG/PSMA3/PSMD11/PSMA6/PSMA2/SDHD/CASP8/PSMC6/NRBF2/PSMD12/SP1/CYCS/PSMA1/PPIF/TFAM/POLR2K/DCTN4/PSMC2/CASP3/PIK3C3/SDHB/PSMA5/POLR2B/ERN1/TUBB2A/ACTR10/NDUFB5/PSMC4/BAX/WIPI1/NDUFB3/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/SLC25A5/SIN3A/ULK2/MT-ND6/ATG2B/VDAC2/MAPK9/TBP/BBC3/PLCB2/HTT/POLR2A/TBPL1/ITPR1/CASP9/POLR2J3/MTOR/GNAQ/IFT57/CREB5/TUBA1B/DNAH3/MAPK8/KCNJ10/NDUFA7/PLCB3/CLTA/DNAH14/MAP3K10/NRF1/MT-ND4L/POLR2J2/TUBB1	0.349439018594574
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/2085	53/9376	1.10300891362382	DNM2/SLC8A1/ATP1A1/PRKCA/VDR/PLCB2/ATP1B1/PRKCB/GNAQ/FXYD2/ATP2B1/PLCB3/CLTA	0.402142541567047
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	27/2085	115/9376	1.05578980294026	DUSP1/NRAS/RAF1/GNAI3/KRAS/PTGS2/GNB4/ALOX5/GNG10/CASP3/MAP2K1/ITPR2/PLA2G4A/PLA2G4C/MAPK1/BRAF/PTGS1/ALOX15B/PRKCA/PLCB2/PRKCB/GNGT2/ITPR1/GNG5/GNAQ/KCNJ5/PLCB3	0.321899219910366
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/2085	93/9376	1.06377865449576	SMURF2/PTPRJ/RAP1A/CTNND1/SMAD4/MAP3K7/NECTIN4/TGFBR2/PDCD10/NLK/CTNNB1/ACTN1/CDC42/MAPK1/FER/CSNK2A1/CTNNA1/FARP2/RAP1B/MYL12A/SMURF1/TCF7	0.330535241624888
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	54/2085	235/9376	1.03332619011174	ACSL1/PPARG/ACSL3/ACSL4/ATF2/SDHD/NRAS/ADCY7/MAP2K3/GRB2/KRAS/COA6/SMARCE1/MAPK13/KDM1A/SDHB/RHEB/SOS2/KDM3B/KDM3A/NDUFAF4/NDUFB5/SIRT6/ARID1B/ACTL6A/SOS1/ACSL5/NDUFB3/UQCRC2/COA1/ATP5F1C/PRKAA1/RPS6KA1/MT-ND6/COX19/PRKAG2/TSC1/COX15/ADCY3/PRKAB1/COX10/AKT1S1/MTOR/RPS6KB1/CREB5/RPTOR/NDUFAF7/COX11/NDUFA7/NDUFAF5/ATP5MGL/NDUFAF6/MT-ND4L/PRKAB2	0.276673690343795
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/2085	19/9376	1.18339013000126	HPSE/ARSB/GALNS/HEXA/HEXB	0.42788746388703
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/2085	98/9376	1.05539078940929	ATF2/CAMK2D/ADCY7/PRKD3/ITPR2/ATP1A1/ATF1/ATF6B/PRKCA/PLCB2/ADCY3/ATP1B1/PRKCB/ITPR1/GNAQ/CREB5/KCNJ5/ATP2B1/PLCB3/DAGLA/NR4A1/POMC/LDLR	0.294759985908797
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/2085	76/9376	1.06505111700114	CAMK2D/ADCY7/GNAI3/HRH2/ITPR2/ATP1A1/KCNJ2/CA2/PRKCA/PLCB2/ADCY3/ATP1B1/PRKCB/SLC9A1/ITPR1/GNAQ/KCNJ10/PLCB3	0.304484506609055
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/2085	107/9376	1.05067347990766	ATF2/PYGL/CAMK2D/PPP3R1/PPP4C/SIRT1/PPP4R3B/ITPR2/PHKB/SIK1/PPP4R3A/PPP3CC/AKT1/PRKAA1/PRKAG2/PLCB2/ACACA/CRTC2/PRKAB1/ITPR1/SIK2/GNAQ/CREB5/PLCB3/PRKAB2	0.281904037627619
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/2085	227/9376	1.03012286206277	SOD2/HIF1A/AHR/PRKCD/SDHD/NRAS/ABL2/PTPRJ/PTEN/CHUK/GRB2/RAF1/KRAS/NFKBIA/MAPK13/PPIF/MAP2K1/SDHB/PRKD3/PIK3CB/SOS2/NCF2/NDUFB5/NCF1/SOS1/NFKB1/ARNT/MAPK1/BRAF/NDUFB3/AKT1/JUN/UQCRC2/VDAC1/ATP5F1C/SLC25A5/GSTO1/HMOX1/MT-ND6/VDAC2/MAPK9/IKBKB/CAT/PIK3CA/FOS/FOXO3/MAPK8/AKR1C3/NDUFA7/MT-ND4L/NQO1/SLC26A6	0.245678678078758
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/2085	50/9376	1.07925179856115	SAT1/P4HA1/AMD1/CNDP2/LAP3/SMS/OAT/ALDH3A2/SAT2/ODC1/GOT1/L3HYPDH	0.300463375779006
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2085	15/9376	1.19916866506795	SLC33A1/HEXA/ST3GAL1/HEXB	0.412810407740402
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	53/2085	232/9376	1.02730505250972	VAV3/NRAS/ACTR3/ITGAV/RAF1/SSH2/KRAS/PDGFB/ITGAX/LIMK2/MAP2K1/PPP1CC/PIK3CB/PIP4K2A/DIAPH2/VAV1/LPAR5/SOS2/PPP1CB/ACTR2/ARHGEF12/SSH1/SOS1/PIKFYVE/ACTN1/CDC42/MAPK1/ARPC1A/BRAF/ARHGEF6/AKT1/PIP4K2C/DIAPH1/ITGAM/FGD3/ARHGEF7/CYFIP1/SPATA13/LIMK1/GNA13/ARPC1B/PIK3CA/SLC9A1/DOCK1/CXCL12/ARPC3/IQGAP3/MYL12A/PPP1R12B/MSN/TMSB4X/LPAR2/ITGA10	0.225197735207806
NA	NA	hsa04517	IgSF CAM signaling	68/2085	299/9376	1.02270237321848	VAV3/CD80/LCP2/MTSS1/NRP2/EPB41L3/RAPGEF2/ICAM1/PMP22/SRGAP2/ACTR3/NCK1/TRIO/GRB2/IL1RAP/RAP1A/ITGAX/MAPK13/CD48/ARF6/MAP2K1/CD2AP/PIK3CB/TRAF6/VAV1/TUBB2A/ERC1/NECTIN4/ACTR2/NRP1/F11R/CTNNB1/ACTN1/CDC42/MAPK1/ARPC1A/AKT1/LYN/SRGAP1/GSK3B/NCK2/CD226/ITGAM/CRTAM/MAPK9/PRKCA/SLAMF7/ARPC1B/PRKCB/SPTAN1/PIK3CA/CD209/PLXNA1/ARPC3/RAP1B/MYL12A/TUBA1B/MSN/GLDN/MAPK8/CD84/PLXNA2/SLAMF1/L1CAM/NTRK3/SRGAP3/DYNLL1/TUBB1	0.213344182136396
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/2085	37/9376	1.09383628232549	GLS/GLUL/NIT2/GLUD1/RIMKLB/ADSL/GOT1/DDO/GPT2	0.305820494577991
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	82/2085	362/9376	1.01863084118341	IL6/PIK3AP1/IL2RA/TLR2/SGK1/HSP90AA1/LPAR6/MCL1/TLR4/EIF4E/OSM/ATF2/NRAS/SGK3/PTEN/CHUK/ITGAV/MDM2/GRB2/CCND1/PPP2R2A/RAF1/KRAS/PDGFB/GNB4/CSF3R/JAK3/GNG10/HSP90AB1/IL4R/BCL2L1/MAP2K1/YWHAG/PIK3CB/RHEB/PPP2CA/LPAR5/SOS2/PPP2CB/JAK2/PIK3CG/ATF6B/CSF1/SOS1/NFKB1/CDKN1B/MAPK1/HSP90B1/AKT1/PPP2R2D/PPP2R5C/PPP2R3C/PRKAA1/GSK3B/EREG/IKBKB/PRKCA/YWHAH/PKN2/TSC1/DDIT4/CRTC2/TGFA/IL7/PIK3CA/GNGT2/CASP9/CDKN1A/BCL2/MTOR/RPS6KB1/IL6R/FOXO3/GNG5/CREB5/RPTOR/MYC/NR4A1/IL3RA/LPAR2/CDK2/ITGA10	0.193318354974782
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/2085	78/9376	1.03774211400111	ACTR3/DNM2/ARHGAP10/CD2AP/ELMO2/PIK3CB/ACTR2/HCLS1/CTNNB1/CDC42/ELMO1/ARPC1A/CTNNA1/ARPC1B/PIK3CA/DOCK1/ARPC3/CLTA	0.178987981851335
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/2085	154/9376	1.02201874863745	KCNE1/ATP2A2/ATF2/CAMK2D/ADCY7/PPP2R2A/GNAI3/SLC8A1/PPP1R1A/MAPK13/SCN1B/PPP1CC/ATP1A1/PPP2CA/PPP1CB/PPP2CB/PIK3CG/ADRB2/ATF6B/MAPK1/AKT1/PPP2R2D/PPP2R5C/PPP2R3C/PRKCA/PLCB2/ADCY3/ATP1B1/SLC9A1/BCL2/GNAQ/FXYD2/CREB5/ATP2B1/PLCB3	0.147328088400199
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/2085	38/9376	1.06505111700114	CD40/TAP1/BTK/JAK3/RFX5/BLNK/DCLRE1C/TAP2/PTPRC	0.214864536328423
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/2085	47/9376	1.052461860299	ME2/ACAT2/DLAT/MDH1/ME1/ALDH3A2/FH/DLD/ACYP1/ACSS2/ACACA	0.192805841528495
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/2085	34/9376	1.05808999858936	POLR2K/POLR2B/POLR2M/POLR3C/POLR2A/POLR2J3/POLR3F/POLR2J2	0.181453776643674
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/2085	75/9376	1.01929336530775	MAT2A/GLUL/IDH1/RPE/MAT2B/ACO1/PRPS1/SDSL/BCAT1/SDS/IDH3A/ALDOA/TALDO1/SHMT1/GOT1/RPIA/GPT2	0.0897054678827747
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/2085	44/9376	1.02201874863745	HSPD1/TNF/CD80/IL1B/HLA-DQB1/IL1A/HLA-F/FAS/HLA-DQA1/PTPRN2	0.0782846700672903
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2085	26/9376	1.03774211400111	LMBRD1/ABCC1/ABCD4/SLC19A2/SLC5A6/SLC19A1	0.103050999734611
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/2085	17/9376	1.05808999858936	NRP2/LAMP1/LAMP2/CD209	0.128190612234183
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/2085	31/9376	1.01542507929141	HSPA5/SRP54/SPCS3/SRP9/SRPRA/SEC61B/IMMP2L	0.0460006234729124
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	43/2085	195/9376	0.991620242267724	AQP9/CASP1/FCGR2A/TLR2/TLR4/FPR1/FPR3/CLEC7A/CASP4/FCGR1A/RAF1/FCGR3A/SIGLEC9/CR1/MAPK13/PPIF/MAP2K1/MAP3K7/PIK3CB/NCF2/NCF4/NCF1/NFKB1/ATG7/MAPK1/AKT1/VDAC1/SLC25A5/HDAC8/ITGAM/VDAC2/PRKCA/FPR2/PLCB2/PRKCB/PIK3CA/MTOR/TLR8/CLCN5/CYBB/HDAC4/PLCB3/FCGR3B	-0.0632337435556129
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/2085	205/9376	0.987120547464467	ATP2A2/PRKCD/SDHD/CAMK2D/PTEN/GSR/SP1/MAPK13/PPIF/SDHB/PPP1CC/PIK3CB/PPP1CB/NCF2/TGFBR2/NDUFB5/NCF4/NCF1/NFKB1/SMAD2/NDUFB3/AKT1/PDK3/UQCRC2/VDAC1/ATP5F1C/SLC25A5/GSK3B/MPC1/MPC2/MT-ND6/VDAC2/MAPK9/PRKCA/PLCB2/PRKCB/PIK3CA/MTOR/PDK4/CYBB/MAPK8/NDUFA7/PLCB3/TGFB2/MT-ND4L	-0.0997036610235074
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/2085	101/9376	0.979518959090154	NRAS/CAMK2D/ADCY7/RAF1/GNAI3/KRAS/FZD5/MAP2K1/DVL3/CTNNB1/MAPK1/FZD2/MITF/GSK3B/PRKCA/PLCB2/ADCY3/PRKCB/GNAQ/PLCB3/TCF7/POMC	-0.110662600474293
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/2085	69/9376	0.977583150870608	PTGER4/KCNMA1/GNAI3/PPP3R1/CTSB/ITPR2/ADRB2/PPP3CC/KCNJ2/PLCB2/PTGER2/ITPR1/GNAQ/PDE1B/PLCB3	-0.0999400071261328
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/2085	46/9376	0.977583150870608	ALAS1/BLVRA/HCCS/HMOX1/COX15/COX10/CPOX/EARS2/FTL/FECH	-0.0815000324444574
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	65/2085	298/9376	0.980863631242657	IL18/CXCL8/IL6/CCL20/CCL3L1/IL2RA/TNF/CCL8/CCL3/IFNGR1/RELT/IL1B/IFNGR2/IL15RA/CCL2/OSM/ACVR1B/IL1A/CCR1/CCL4L2/CD40/TNFRSF9/IL10RA/IL10/TNFRSF10B/IL1RAP/CSF3R/TNFRSF10A/IL4R/TNFSF9/IL10RB/CXCL1/TGFBR2/FAS/TNFRSF1A/TNFSF15/CSF1/IL27RA/TNFRSF10D/ACVR1/TNFRSF14/CCR5/CCL4/CCL7/CXCL10/CCL18/CXCL3/TNFSF12/TNFSF13/IL13RA1/IL7/CCL23/TNFSF13B/CXCL16/CXCL12/IL23A/IL6R/LIF/IL12RB1/ACKR3/CXCL2/TGFB2/ACVR2A/TNFSF8/IL3RA	-0.179522006142069
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/2085	212/9376	0.975738654359531	VAV3/LCP2/FPR1/RAPGEF2/NRAS/DOCK4/ADCY7/MAP2K3/RAF1/GNAI3/KRAS/PDGFB/RAP1A/VASP/APBB1IP/MAPK13/MAP2K1/CTNND1/PRKD3/PIK3CB/RALB/VAV1/LPAR5/P2RY1/CSF1/CTNNB1/CDC42/MAPK1/BRAF/AKT1/RALGDS/RAPGEF1/RASSF5/ITGAM/RASGRP3/PRKCA/FARP2/PLCB2/ADCY3/PRKCB/PIK3CA/SIPA1L3/GNAQ/RAP1B/PLCB3/LPAR2	-0.191066872126308
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	22/2085	102/9376	0.96991583204025	ATP2A2/KCNMA1/RAB8A/ADCY7/RAP1A/ITPR2/ATP1A1/BST1/CA2/CD38/PRKCA/PLCB2/ADCY3/ATP1B1/PRKCB/SLC9A1/ITPR1/GNAQ/FXYD2/RAP1B/ATP2B1/PLCB3	-0.163361481576885
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/2085	23/9376	0.977583150870608	GLS/GLUL/GLUD1/GOT1/GPT2	-0.0575583238623843
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/2085	79/9376	0.96768357465926	SLC1A3/ATP6V1C1/NSF/DNM2/ATP6V1H/ATP6V1B2/STX3/ATP6V1A/ATP6V0A1/ATP6V1D/STX2/ATP6V1G1/UNC13B/ATP6V1E2/ATP6V0D2/SLC6A12/CLTA	-0.154244811627457
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	25/2085	116/9376	0.969155709914827	SLC1A3/GLS/GLUL/ADCY7/SLC38A2/GNAI3/PPP3R1/GNB4/GNG10/HOMER3/ITPR2/PLA2G4A/PPP3CC/PLA2G4C/MAPK1/GRK3/PRKCA/PLCB2/ADCY3/PRKCB/GNGT2/ITPR1/GNG5/GNAQ/PLCB3	-0.178748908668832
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/2085	93/9376	0.967071504087053	KCNMA1/ADCY7/PRH1/ITPR2/ATP1A1/ADRB2/BST1/CD38/PRKCA/PLCB2/ADCY3/ATP1B1/PRKCB/SLC9A1/ITPR1/GNAQ/FXYD2/KCNN4/ATP2B1/PLCB3	-0.17065315094808
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/2085	28/9376	0.963617677286742	GCH1/MOCS2/FPGS/PTS/GPHN/AKR1C3	-0.103099178379137
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	51/2085	238/9376	0.963617677286742	TBK1/NF1/NRAS/ABL2/CHUK/GRB2/RAF1/RGL1/KRAS/PDGFB/GNB4/RAP1A/GNG10/SHOC2/RAB5A/RASA2/BCL2L1/ARF6/MAP2K1/PIK3CB/RALB/SOS2/RAB5B/PLA2G4A/CSF1/SOS1/NFKB1/CDC42/PLA2G4C/MAPK1/AKT1/RALGDS/RALGAPB/RASSF5/RALGAPA1/RASGRP3/ETS2/MAPK9/IKBKB/PRKCA/RASAL2/EXOC2/TGFA/PRKCB/PIK3CA/GNGT2/ELK1/GNG5/RAP1B/MAPK8/PLA1A	-0.304017401134644
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/2085	39/9376	0.92243743466765	TNF/CD80/HLA-DQB1/HLA-F/CD40/IL10/FAS/HLA-DQA1	-0.259552913066793
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/2085	268/9376	0.956426500590572	HSPA5/SLC11A2/DDIT3/XBP1/PSMA3/PSMD11/PSMA6/DUSP1/PSMA2/SDHD/CAMK2D/LRRK2/SLC39A8/UBE2J1/GNAI3/PSMC6/PSMD12/CYCS/UBE2G1/PSMA1/PPIF/EIF2S1/BCL2L1/PSMC2/CASP3/SDHB/ITPR2/UBE2G2/PSMA5/SLC39A11/ERN1/TUBB2A/TXN/NDUFB5/EIF2AK3/PSMC4/BAX/NDUFB3/PSMD6/UQCRC2/VDAC1/ATP5F1C/PSMD9/SLC25A5/MT-ND6/VDAC2/MAPK9/MCU/SNCA/ITPR1/CASP9/TUBA1B/MFN1/MAPK8/NDUFA7/MT-ND4L/TUBB1	-0.387011120650661
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/2085	49/9376	0.917731121225469	COLGALT1/OGT/GALNT1/B4GALT1/C1GALT1/GALNT12/GXYLT1/C1GALT1C1/GALNT10/ST6GAL1	-0.308750556325876
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/2085	30/9376	0.899376498800959	PIGA/PIGK/PIGG/PIGN/PIGF/PIGB	-0.295183638939847
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/2085	45/9376	0.899376498800959	IL6/TNF/CD80/IL1B/HLA-DQB1/IL1A/HLA-F/FAS/HLA-DQA1	-0.361815114746218
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/2085	50/9376	0.899376498800959	IL6/CD80/IL15RA/HLA-DQB1/CD40/IL10/HLA-DQA1/TNFSF13/TNFSF13B/CXCL12	-0.381488841917425
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/2085	31/9376	0.870364353678348	RPE/PRPS1/ALDOA/DERA/TALDO1/RPIA	-0.386599021142963
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/2085	36/9376	0.87439381827871	B4GALT5/GALNT1/C1GALT1/GALNT12/ST3GAL1/C1GALT1C1/GALNT10	-0.403769904179158
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/2085	51/9376	0.881741665491137	AGPS/LPCAT2/CHPT1/PLA2G7/CEPT1/PLA2G4A/PLA2G4C/PAFAH1B1/SELENOI/LPCAT4	-0.452832454173328
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/2085	203/9376	0.930389481518234	VAV3/BIRC2/PTEN/PARVG/ITGAV/GRB2/CCND1/RAF1/PDGFB/RAP1A/VASP/MAP2K1/PPP1CC/PIK3CB/VAV1/SOS2/PPP1CB/SOS1/CTNNB1/ACTN1/CDC42/MAPK1/BRAF/AKT1/XIAP/JUN/RAPGEF1/GSK3B/DIAPH1/MAPK9/PRKCA/PRKCB/PIK3CA/DOCK1/BCL2/ELK1/RAP1B/MYL12A/PPP1R12B/MAPK8/BIRC3/ITGA10	-0.536182097723011
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/2085	42/9376	0.856549046477104	KYNU/KMO/ACAT2/ALDH3A2/DLD/CAT/IDO1/EHHADH	-0.498240819283563
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2085	32/9376	0.843165467625899	UGP2/HK2/HK3/GLA/B4GALT1/GALE	-0.475220740127224
Human Diseases	Immune disease	hsa05310	Asthma	6/2085	32/9376	0.843165467625899	TNF/HLA-DQB1/CD40/IL10/HLA-DQA1/FCER1G	-0.475220740127224
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/2085	86/9376	0.888918632535832	KCNMA1/ATF2/CAMK2D/ADCY7/ATP1A1/ATF6B/KCNMB1/PRKCA/PLCB2/ADCY3/ATP1B1/PRKCB/GNAQ/FXYD2/CREB5/KCNN4/PLCB3	-0.553385410072406
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/2085	52/9376	0.864785095000922	ADCY7/PTGS2/ALOX5/HSD17B7/PLA2G4A/PLA2G4C/ADCY3/AKR1C3/ACOT2/LDLR	-0.522841708924433
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2085	22/9376	0.817614998909963	CNDP2/HNMT/ALDH3A2/CARNMT1	-0.457980404636232
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2085	17/9376	0.793567498942023	HSD17B4/SCP2/CH25H	-0.455546726429099
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2085	17/9376	0.793567498942023	CSAD/ADO/FMO4	-0.455546726429099
NA	NA	hsa03272	Virion - Hepatitis viruses	9/2085	48/9376	0.843165467625899	PDCD6IP/LAMP1/IST1/TSG101/CHMP7/CLDN23/LAMP2/OCLN/LDLR	-0.582523113474882
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/2085	63/9376	0.856549046477104	POLK/FZD5/DVL3/GADD45A/CTNNB1/BAX/FZD2/GSK3B/CDKN1A/AXIN1/TCF7/PTCH2	-0.610905494698753
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/2085	28/9376	0.803014731072285	ELOVL5/HADHB/HSD17B12/ELOVL7/ACOT2	-0.558211182372916
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/2085	184/9376	0.904264414555312	PLXNC1/NRAS/SRGAP2/CAMK2D/NCK1/RAF1/GNAI3/SSH2/PPP3R1/KRAS/SEMA4D/LIMK2/SEMA4A/SEMA6B/PIK3CB/ARHGEF12/NRP1/SSH1/RYK/PPP3CC/CDC42/MAPK1/SRGAP1/GSK3B/NCK2/PRKCA/LIMK1/PIK3CA/SEMA3C/CXCL12/PLXNA1/LRIG2/MYL12A/PLXNA2/L1CAM/SRGAP3/LRRC4	-0.701330005200755
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/2085	69/9376	0.847238730754527	ATF2/CAMK2D/PPP3R1/SIRT1/PPP1CC/PPP1CB/ATF6B/PPP3CC/JUN/PRKCA/PRKCB/FOS/CREB5	-0.681048538484036
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/2085	44/9376	0.817614998909963	NSF/RAB5A/DCTN4/STX4/RAB5B/ADCY3/CREB5/DYNLL1	-0.648445098795004
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/2085	100/9376	0.854407673860911	IL6/IL2RA/TNF/IL1B/HLA-DQB1/IL1A/FCGR1A/CD44/CSF3R/CR1/IL4R/CD55/CSF1/HLA-DQA1/ITGAM/CD38/IL7/IL6R/IL3RA	-0.782714237374417
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/2085	91/9376	0.840076949429467	ADCY7/GNAI3/GNB4/PDE7A/PDE4B/GNG10/PDE8A/ARRB1/GRK3/PRKCA/ARRB2/ADCY3/PRKCB/GNGT2/GNG5/KCNJ5/PDE1B	-0.819758495840102
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/2085	19/9376	0.710034078000757	DLAT/DLD/BCKDHB	-0.676551038908509
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/2085	97/9376	0.834473040124601	CAMK2D/ADCY7/GNAI3/GNB4/GNG10/MAPK1/PRKCA/PLCB2/ADCY3/PRKCB/PER1/GNGT2/FOS/ITPR1/GNG5/GNAQ/KCNJ5/PLCB3	-0.876292585872198
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2085	36/9376	0.749480415667466	UGP2/HK2/PYGL/HK3/GBE1/GYG1	-0.805312821190591
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/2085	99/9376	0.817614998909963	FCGR2A/FPR1/FCGR2B/HLA-DQB1/FPR3/ICAM1/FCGR1A/IL10/FCGR3A/PTAFR/C3AR1/HLA-DQA1/C1QC/ITGAM/FPR2/FCAR/DEFB1/FCGR3B	-0.975546685818739
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/2085	134/9376	0.838970614553134	KCNMA1/ARHGEF11/PRKCD/ADCY7/RAF1/MAP2K1/PPP1CC/ITPR2/PPP1CB/PLA2G4A/ARHGEF12/PLA2G4C/MAPK1/BRAF/KCNMB1/PTGIR/PRKCA/PLCB2/ADCY3/GNA13/PRKCB/ITPR1/GNAQ/PPP1R12B/PLCB3	-1.00396753947261
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/2085	59/9376	0.762183473560135	ADCY7/GNAI3/PTGS2/ABHD5/PIK3CB/ADRB2/AKT1/PTGS1/ADCY3/PIK3CA	-0.979884997144507
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/2085	21/9376	0.642411784857828	DSE/CSGALNACT2/CHST12	-0.877235236019169
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/2085	27/9376	0.666204813926636	HMGCS1/ACAT2/AACS/EHHADH	-0.928804883122575
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	27/2085	149/9376	0.814871324416976	ADCY7/GNAI3/PTGS2/GNB4/GNG10/MAPK13/ITPR2/NDUFB5/MAPK1/NDUFB3/MT-ND6/MAPK9/PRKCA/PLCB2/ADCY3/PRKCB/GNGT2/ITPR1/GNG5/GNAQ/KCNJ5/MAPK8/NDUFA7/PLCB3/DAGLA/NAPEPLD/MT-ND4L	-1.21809647616606
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/2085	89/9376	0.757901543933393	GLS/GLUL/NSF/ADCY7/SLC38A2/GNAI3/GNB4/GNG10/PRKCA/ADCY3/PRKCB/GNGT2/GNG5/GPHN/SLC6A12	-1.22714086592906
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/2085	41/9376	0.658080364976312	ALAS1/SDSL/SDS/DLD/SHMT1/BPGM	-1.17328610434495
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2085	63/9376	0.713790872064253	PTGES3/PTGS2/ALOX5/PTGR1/PLA2G4A/PLA2G4C/PTGS1/ALOX15B/LTA4H/AKR1C3	-1.21886069485749
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/2085	59/9376	0.685965126204122	IDH1/GCLM/GSR/LAP3/RRM2B/SMS/ODC1/GSTO1/CHAC2	-1.29393051870413
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/2085	138/9376	0.782066520696486	ATP6V1C1/SDHD/ATP6V1H/ATP6V1B2/CYCS/ATP6V1A/ATP6V0A1/ATP6V1D/SDHB/NDUFB5/NDUFB3/UQCRC2/ATP5F1C/MT-ND6/COX15/ATP6V1G1/PPA2/COX10/ATP6V1E2/ATP6V0D2/COX11/NDUFA7/ATP5MGL/MT-ND4L	-1.37917582314075
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/2085	65/9376	0.691828076000738	GK/GLA/ALDH3A2/AGPAT3/DGKG/DGKD/DGKE/LPIN3/DGKQ/DGKH	-1.33320429323903
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/2085	26/9376	0.518871057000553	ACOX1/PLA2G4A/PLA2G4C	-1.31367359485735
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/2085	67/9376	0.671176491642507	ADPGK/HK2/HK3/MINPP1/DLAT/ALDOA/ALDH3A2/DLD/ACSS2/BPGM	-1.44442123201319
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/2085	90/9376	0.699515054622968	AQP9/ADCY7/ABCC3/NCEH1/ATP1A1/HMGCR/CA2/ADCY3/ATP1B1/SLC9A1/FXYD2/ABCB4/ABCG2/LDLR	-1.53170366686139
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/2085	226/9376	0.795908406018548	VAV3/ATP2A2/CAMK2D/ADCY7/SUCNR1/RAF1/GNAI3/NFKBIA/PDE4B/RAP1A/ACOX1/MAP2K1/PPP1CC/PIK3CB/ATP1A1/HCAR3/VAV1/PPP1CB/ADRB2/NFKB1/MAPK1/BRAF/AKT1/HCAR2/JUN/MAPK9/ADCY3/ATP1B1/PIK3CA/FOS/SLC9A1/PTGER2/NFATC1/FXYD2/CREB5/RAP1B/MAPK8/ATP2B1/FFAR2/POMC	-1.66078689359243
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/2085	82/9376	0.658080364976312	DPYD/TPMT/UPP1/RRM2B/HPRT1/CMPK1/GSTO1/CDADC1/NME7/CES1/UCKL1/NAT1	-1.66293300138732
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/2085	54/9376	0.582929212185807	CD80/HLA-DQB1/HLA-F/CD40/IL10/FAS/HLA-DQA1	-1.64360412179442
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/2085	49/9376	0.550638672735281	ATF2/GNAI3/ATF6B/NFKB1/JUN/CREB5	-1.68642823204814
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/2085	23/9376	0.391033260348243	FUT4/B4GALT1	-1.56360533186346
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/2085	15/9376	0.299792166266986	TPK1	-1.45129798027084
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2085	37/9376	0.486149458811329	COMT/FAH/FAHD1/GOT1	-1.67468299842052
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2085	16/9376	0.2810551558753	GOT1	-1.5390855446599
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	57/2085	323/9376	0.793567498942023	PLAU/GLS/MCL1/NRAS/MARCKS/ZEB2/PTEN/MDM4/MDM2/GRB2/CCND1/RAF1/KRAS/ST14/PTGS2/CD44/PDGFB/SIRT1/SOCS1/STAT3/CASP3/MAP2K1/EZH2/DNMT3A/PIM1/PIK3CB/DICER1/SOS2/ATM/E2F3/SOS1/NFKB1/ABCC1/CDKN1B/MAPK1/BMI1/NOTCH2/SPRY2/UBE2I/HMOX1/IKBKB/PRKCA/DDIT4/BMF/BCL2L2/MAPK7/PRKCB/PIK3CA/CDKN1A/CDKN2A/BCL2/MTOR/CCNG1/RPTOR/MYC/HDAC4/TGFB2	-2.01896222843768
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/2085	99/9376	0.590499721434973	IL6/ATP2A2/TNF/ITGAV/SLC8A1/SNTB1/PRKAA1/PRKAG2/PRKAB1/TGFB2/ITGA10/PRKAB2/SSPN	-2.19034809446173
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/2085	36/9376	0.374740207833733	UGP2/RPE/DHDH	-2.00994157222489
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/2085	88/9376	0.5621103117506	PLAU/PLAUR/SERPINA1/CR1/ITGAX/CD55/C3AR1/THBD/C1QC/VSIG4/ITGAM	-2.20693768021033
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/2085	29/9376	0.310129827172745	PDE6G/PDE6A	-1.98964394500005
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	41/2085	254/9376	0.725874733284239	P2RX4/ATP2A2/MCOLN2/CAMK2D/ADCY7/PPP3R1/PDGFB/SLC8A1/PTAFR/HRH2/PPIF/GNA15/P2RX7/ITPR2/PHKB/ADRB2/MCOLN1/ORAI3/PPP3CC/ASPH/MCOLN3/VDAC1/PTK2B/SLC25A5/VDAC2/CD38/PRKCA/MCU/PLCB2/ADCY3/TGFA/PRKCB/NFATC1/ITPR1/STIM2/GNAQ/CHRFAM7A/PDE1B/ATP2B1/PLCB3/NTRK3	-2.36845975917412
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2085	30/9376	0.299792166266986	PLA2G4A/PLA2G4C	-2.05409167751627
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/2085	160/9376	0.646426858513189	CD80/SDC4/HLA-DQB1/ICAM1/HLA-F/CD40/ITGAV/SDC2/SDC3/CD58/CD274/F11R/PDCD1LG2/HLA-DQA1/CD226/ITGAM/CD276/CLDN23/SELL/OCLN/PTPRC/L1CAM/LRRC4	-2.41219906208226
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/2085	87/9376	0.516883045287908	ATP2A2/SLC8A1/ATP1A1/ASPH/UQCRC2/SLC9A6/ATP1B1/SLC9A1/FXYD2/SLC9A7	-2.4208759872817
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/2085	23/9376	0.195516630174122	PREP	-2.06562100119715
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	26/2085	183/9376	0.638901337946037	UTP18/NXF1/XPO1/XRN1/AK6/RPP30/EFL1/UTP6/BMS1/NXT2/WDR36/GNL3/NOP10/NMD3/RIOK2/NOP58/CSNK2A1/RPP25/NXT1/NAT10/UTP14A/NVL/UTP15/NOL6/RPP40/PWP2	-2.63795821948987
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/2085	103/9376	0.523908640078229	SLC36A4/SLC38A2/SLC8A1/SLC7A7/ATP1A1/SLC36A1/SLC3A2/KCNE3/ATP1B1/COL8A2/FXYD2/KCNN4	-2.59802844186507
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2085	26/9376	0.172957019000184	HHEX	-2.25815665791865
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/2085	86/9376	0.470603981930734	ATP2A2/ITGAV/SLC8A1/SNTB1/CTNNB1/CTNNA1/TCF7/ITGA10/SSPN	-2.63734629162231
NA	NA	hsa04082	Neuroactive ligand signaling	28/2085	199/9376	0.632727185086102	SLC1A3/P2RX4/OGFRL1/ADCY7/GNAI3/GNB4/GNG10/OGFR/HRH2/ADORA3/P2RY6/P2RY1/ADRB2/SLC17A9/ACHE/PRKCA/P2RY13/PLCB2/ADCY3/PRKCB/GNGT2/GNG5/GNAQ/CHRFAM7A/ADRA2B/SLC6A12/PLCB3/POMC	-2.80033555588119
NA	NA	hsa04518	Integrin signaling	20/2085	154/9376	0.584010713507116	ICAM1/PARVG/ITGAV/CCND1/PDGFB/FERMT3/ITGAX/ICAM4/PIK3CB/CTNNB1/ACTN1/CDC42/ARHGEF6/AKT1/GSK3B/NCK2/ITGAM/PIK3CA/MTOR/ITGA10	-2.78339643106289
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/2085	194/9376	0.602674973423323	DYNLT3/CAPZA2/DYNLT1/MYO1G/DCTN4/CAPZA1/MYO1E/KIFC3/MYO5A/MYO5B/TUBB2A/KIF1B/ACTR10/MYO7A/KIF13B/MYO9B/MYO15B/MYL12A/TUBA1B/DNAH3/TUBD1/TUBE1/DNAH14/KIFC2/DYNLL1/TUBB1	-2.99035852502518
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/2085	31/9376	0.145060725613058	ALDH3A2	-2.54959724422234
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/2085	66/9376	0.340672916212485	COMT/HSD17B7/HSD17B12/AKR1C3/RDH5	-2.87437324692639
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/2085	43/9376	0.209157325302549	ABCA1/ACAT2	-2.77944964175511
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/2085	105/9376	0.428274523238552	ATP2A2/TNF/ITGAV/ADCY7/SLC8A1/SNTB1/ADCY3/TGFB2/ITGA10/SSPN	-3.15038784409478
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/2085	70/9376	0.321205892428914	PTGS2/GSTO1/SULT1A1/SULT1A3/NAT1	-3.04825067269246
NA	NA	hsa04519	Cadherin signaling	62/2085	404/9376	0.690115630268063	FMN1/VAV3/MOB1B/SAV1/MOB1A/NRAS/TAOK3/ACTR3/CHUK/LHFPL2/PSEN1/MAP2K3/RAF1/KRAS/NFKBIA/VASP/LIMD1/SHOC2/MYO1G/MAPK13/FZD5/ERBIN/MAP2K1/CTNND1/NCSTN/MYO1E/YWHAG/SCN1B/PPP1CC/VAV1/PPP1CB/LATS1/ACTR2/DVL3/RYK/NFKB1/CTNNB1/ACTN1/CDC42/MAPK1/ARPC1A/FZD2/ADAM10/STK3/CSNK1A1/PTK2B/GSK3B/MYO7A/CTNNA1/CYFIP1/MAPK9/IKBKB/TMC8/YWHAH/ARPC1B/ARPC3/CDH23/AXIN1/MAPK8/TCF7/PCDHGA10/VANGL1	-3.40479399434035
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/2085	86/9376	0.36602531927946	P2RY1/PKD2L1/TAS2R30/PLCB2/PDE1B/PLCB3/TAS2R31	-3.15833651200979
NA	NA	hsa04081	Hormone signaling	27/2085	219/9376	0.554410170493742	ITGAV/ADCY7/ADIPOR1/GNAI3/GNB4/GNG10/STAT3/GNA15/SMAD4/PIK3CB/JAK2/ADRB2/STAT5A/ACVR1/ADIPOR2/PLCB2/ADCY3/GNA13/PIK3CA/GNGT2/GNG5/GNAQ/ADRA2B/HAMP/THRB/PLCB3/POMC	-3.56800815778391
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2085	41/9376	0.109680060829385	CHRFAM7A	-3.05510390761195
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/2085	143/9376	0.440254230182288	FCGR2A/TNF/CD80/HLA-DQB1/CD40/FCGR1A/IL10/FCGR3A/ACTN1/TRIM21/HLA-DQA1/C1QC/SSB/FCGR3B	-3.60688702747129
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/2085	191/9376	0.494421635466496	ATF2/NRAS/GRB2/RAF1/GNAI3/KRAS/GNB4/GNG10/MAP2K1/PPP1CC/SOS2/PPP1CB/ATF6B/SOS1/MAPK1/BRAF/HDAC8/GNGT2/GNG5/CREB5/HDAC4	-3.77494564567196
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/2085	68/9376	0.198391874735506	RDH11/DHRS4/RDH5	-3.54759062404061
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/2085	89/9376	0.252633847977798	SDC4/CD47/ITGAV/CD44/ITGA10	-3.78822550898991
Genetic Information Processing	Translation	hsa03010	Ribosome	22/2085	222/9376	0.445637003910385	MRPL18/DAP3/MRPL32/RPL22L1/MRPL44/MRPL3/MRPS35/RPS10/MRPL47/MRPS31/MRPS30/MRPS25/MRPL50/MRPL42/MRPL19/MRPL39/MRPL13/RPL17/MRPS22/MRPL53/MRPL10/MRPS17	-4.47002945798826
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/2085	73/9376	0.12320226010972	GSTO1/FMO4	-4.02155914257992
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/2085	233/9376	0.424598347073414	FMNL2/AMPD3/SDC4/CAPZA2/ITGAV/SDC2/SDC3/CAPZA1/SNTB1/LBR/TMOD3/ATP1A1/DIAPH2/FMNL3/DIAPH1/PDLIM5/SYNE1/ATP1B1/SPTAN1/LMNB2/ITGA10/SSPN	-4.7560873746692
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/2085	79/9376	0.113845126430501	GSTO1/DHDH	-4.22957644929148
NA	NA	hsa04382	Cornified envelope formation	14/2085	217/9376	0.290121451226116	UGCG/S100A8/PPP2R2A/ST14/SPTLC1/ABHD5/PPP2CA/PPP2CB/PPP2R2D/PPP2R5C/PPP2R3C/CLDN23/OCLN/S100A9	-5.65763608449334
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	29/2085	370/9376	0.352458357638214	P2RX4/OGFRL1/PTGER4/LPAR6/FPR1/FPR3/PTAFR/OGFR/HRH2/P2RX7/ADORA3/P2RY6/P2RY1/ADRB2/C3AR1/PTGIR/NR3C1/FPR2/P2RY13/PTGER2/LTB4R/CHRFAM7A/CHRNB1/ADRA2B/THRB/NMB/POMC/LPAR2/PAQR6	-6.79591145727798
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/2085	449/9376	0.100153284944428	CAMK2D/SLC8A1/ARRB1/GRK3/ARRB2/ADCY3/SLC24A4/PDE1B/RGS2/OR2B11	-10.4492244374609