ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0019787 ubiquitin-like protein transferase activity 182/4302 479/18639 0.379958246346555 1.64622077025882 8.27947314690222e-14 9.47650786389888e-11 GO:0030695 GTPase regulator activity 184/4302 489/18639 0.376278118609407 1.63027611640184 1.71106964190358e-13 9.47650786389888e-11 GO:0060589 nucleoside-triphosphatase regulator activity 184/4302 490/18639 0.375510204081633 1.62694902228674 2.12477754795939e-13 9.47650786389888e-11 GO:0016755 aminoacyltransferase activity 184/4302 496/18639 0.370967741935484 1.60726818733972 7.59384920985438e-13 2.54014256069629e-10 GO:0005096 GTPase activator activity 109/4302 271/18639 0.402214022140221 1.7426469452979 1.75589688159087e-10 4.35413609194662e-08 GO:0004842 ubiquitin-protein transferase activity 162/4302 449/18639 0.360801781737194 1.56322278238018 2.12364750075538e-10 4.35413609194662e-08 GO:0106310 protein serine kinase activity 136/4302 361/18639 0.376731301939058 1.63223959480291 2.27794862807372e-10 4.35413609194662e-08 GO:0004674 protein serine/threonine kinase activity 156/4302 433/18639 0.360277136258661 1.56094968450144 5.17531944037599e-10 8.65572176402884e-08 GO:0003712 transcription coregulator activity 173/4302 495/18639 0.349494949494949 1.51423439415071 8.90701695488049e-10 1.32417652062557e-07 GO:0031267 small GTPase binding 110/4302 283/18639 0.3886925795053 1.68406345639221 1.5282831176141e-09 2.04484281136767e-07 GO:0061659 ubiquitin-like protein ligase activity 135/4302 372/18639 0.362903225806452 1.57232757457147 4.43253956255939e-09 5.39157994064042e-07 GO:0051020 GTPase binding 118/4302 315/18639 0.374603174603175 1.62301919373049 5.12726229239923e-09 5.39743025684873e-07 GO:0044389 ubiquitin-like protein ligase binding 120/4302 322/18639 0.372670807453416 1.61464695028457 5.42403037811914e-09 5.39743025684873e-07 GO:0140098 catalytic activity, acting on RNA 139/4302 387/18639 0.359173126614987 1.55616641259339 5.64753539580585e-09 5.39743025684873e-07 GO:0031072 heat shock protein binding 60/4302 131/18639 0.458015267175573 1.98441342744898 8.06299528262753e-09 7.19219179210376e-07 GO:0031625 ubiquitin protein ligase binding 112/4302 302/18639 0.370860927152318 1.60680539776663 2.35837984693017e-08 1.97219514699535e-06 GO:0016887 ATP hydrolysis activity 144/4302 417/18639 0.345323741007194 1.49616206616297 5.35203784494847e-08 4.21236860973003e-06 GO:0043021 ribonucleoprotein complex binding 72/4302 177/18639 0.406779661016949 1.7624281965818 1.22137070341221e-07 9.07885556203075e-06 GO:0035403 histone H3T6 kinase activity 93/4302 247/18639 0.376518218623482 1.63131638236241 1.58571200645394e-07 1.1166750866502e-05 GO:0004679 AMP-activated protein kinase activity 93/4302 248/18639 0.375 1.62473849372385 1.96812235174359e-07 1.31667385331646e-05 GO:0140857 histone H3T45 kinase activity 92/4302 246/18639 0.373983739837398 1.620335408375 2.63407393240429e-07 1.49121017048663e-05 GO:0035091 phosphatidylinositol binding 103/4302 284/18639 0.362676056338028 1.57134333195828 3.01054555001188e-07 1.49121017048663e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0004711 ribosomal protein S6 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0035175 histone H3S10 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0035979 histone H2AXS139 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0044022 histone H3S28 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0044023 histone H4S1 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0044024 histone H2AS1 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0044025 histone H2BS14 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0072354 histone H3T3 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0072371 histone H2AS121 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0140823 histone H2BS36 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0140855 histone H3S57 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0140995 histone H2A kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0140997 histone H4 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0140998 histone H2B kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:1990244 histone H2AT120 kinase activity 91/4302 245/18639 0.371428571428571 1.60926479378362 4.34657673011797e-07 1.49121017048663e-05 GO:0004677 DNA-dependent protein kinase activity 91/4302 246/18639 0.369918699186992 1.60272306697962 5.35198159845317e-07 1.79023784468259e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 90/4302 243/18639 0.37037037037037 1.60467999380133 5.79547613961999e-07 1.8732184915628e-05 GO:0140662 ATP-dependent protein folding chaperone 24/4302 40/18639 0.6 2.59958158995816 5.88005804526441e-07 1.8732184915628e-05 GO:0005085 guanyl-nucleotide exchange factor activity 86/4302 230/18639 0.373913043478261 1.62002910678552 6.43164813970434e-07 1.99922941630183e-05 GO:0035402 histone H3T11 kinase activity 91/4302 247/18639 0.368421052631579 1.59623430962343 6.57444651100751e-07 1.99922941630183e-05 GO:0061630 ubiquitin protein ligase activity 121/4302 353/18639 0.342776203966006 1.48512451550962 9.34186169317778e-07 2.77764687677153e-05 GO:0140097 catalytic activity, acting on DNA 116/4302 336/18639 0.345238095238095 1.49579099422196 1.03959212303865e-06 3.00430718016882e-05 GO:0043130 ubiquitin binding 45/4302 100/18639 0.45 1.94968619246862 1.05532464475287e-06 3.00430718016882e-05 GO:0060590 ATPase regulator activity 27/4302 49/18639 0.551020408163265 2.38737084792076 1.24424299793991e-06 3.4683273567575e-05 GO:0019887 protein kinase regulator activity 92/4302 255/18639 0.36078431372549 1.56314709984412 1.63430949205306e-06 4.46266551095305e-05 GO:0032182 ubiquitin-like protein binding 51/4302 120/18639 0.425 1.84137029288703 1.7485591839894e-06 4.67914437635563e-05 GO:0016779 nucleotidyltransferase activity 56/4302 136/18639 0.411764705882353 1.78402658134383 1.87432496454963e-06 4.9173466717008e-05 GO:0051087 protein-folding chaperone binding 55/4302 134/18639 0.41044776119403 1.77832073939924 2.59494942538681e-06 6.57691344924876e-05 GO:0000287 magnesium ion binding 84/4302 230/18639 0.365217391304348 1.58235401127888 2.60520487899988e-06 6.57691344924876e-05 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 117/4302 349/18639 0.335243553008596 1.45248828092218 4.75523085587934e-06 0.00011782405342901 GO:0035173 histone kinase activity 120/4302 360/18639 0.333333333333333 1.4442119944212 4.93651931495927e-06 0.000120092051698464 GO:0008234 cysteine-type peptidase activity 70/4302 187/18639 0.374331550802139 1.62184234667621 6.4977866756871e-06 0.000155250688786953 GO:0008168 methyltransferase activity 75/4302 204/18639 0.367647058823529 1.59288087619985 6.63506422388138e-06 0.000155749402307952 GO:0003924 GTPase activity 111/4302 331/18639 0.335347432024169 1.45293835088296 8.10486346923706e-06 0.000186970815893779 GO:0140297 DNA-binding transcription factor binding 154/4302 488/18639 0.315573770491803 1.36726627340696 8.43852657641805e-06 0.00019136861964826 GO:0140996 histone H3 kinase activity 118/4302 357/18639 0.330532212885154 1.43207575917396 9.2098940914185e-06 0.000205380638238633 GO:0140101 catalytic activity, acting on a tRNA 55/4302 139/18639 0.39568345323741 1.7143523674784 9.59207869090034e-06 0.000210396742433191 GO:0019207 kinase regulator activity 98/4302 287/18639 0.341463414634146 1.47943667721196 1.16373695400508e-05 0.000251141942654645 GO:0061791 GTPase motor activity 22/4302 40/18639 0.55 2.38294979079498 1.25033278171905e-05 0.000261397697178139 GO:1990606 membrane scission GTPase motor activity 22/4302 40/18639 0.55 2.38294979079498 1.25033278171905e-05 0.000261397697178139 GO:0030544 Hsp70 protein binding 26/4302 51/18639 0.509803921568627 2.20879481499713 1.29961916937962e-05 0.000267521607481527 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 63/4302 167/18639 0.377245508982036 1.63446746674016 1.38458599057477e-05 0.000277639826530022 GO:0005525 GTP binding 123/4302 378/18639 0.325396825396825 1.40982599455403 1.39027416872283e-05 0.000277639826530022 GO:0016741 transferase activity, transferring one-carbon groups 77/4302 215/18639 0.358139534883721 1.5516882358665 1.50040372015052e-05 0.000295226496700205 GO:0043022 ribosome binding 46/4302 112/18639 0.410714285714286 1.77947549312612 1.62309936230664e-05 0.000314740137212505 GO:0004860 protein kinase inhibitor activity 37/4302 84/18639 0.44047619047619 1.90842299262801 1.68961405876682e-05 0.000319797519810106 GO:0141003 histone H2AX kinase activity 116/4302 354/18639 0.327683615819209 1.41973382502423 1.6969823547472e-05 0.000319797519810106 GO:0061665 SUMO ligase activity 11/4302 14/18639 0.785714285714286 3.40421398684997 1.75456028095729e-05 0.000326055785544563 GO:0140674 ATP-dependent histone chaperone activity 58/4302 152/18639 0.381578947368421 1.65324267782427 2.01664640440547e-05 0.000369626423163633 GO:0019789 SUMO transferase activity 17/4302 28/18639 0.607142857142857 2.63052898983861 2.14691467297737e-05 0.000383038723550089 GO:0008094 ATP-dependent activity, acting on DNA 75/4302 210/18639 0.357142857142857 1.54736999402271 2.14707804680543e-05 0.000383038723550089 GO:0019783 ubiquitin-like protein peptidase activity 50/4302 127/18639 0.393700787401575 1.70576219813528 2.79527204235105e-05 0.000492114999034962 GO:0140713 histone chaperone activity 61/4302 164/18639 0.371951219512195 1.61152923767731 3.08845884657496e-05 0.000536669861911337 GO:0000510 H3-H4 histone complex chaperone activity 57/4302 151/18639 0.377483443708609 1.63549835129818 3.400232401628e-05 0.000561668018935588 GO:0140584 chromatin extrusion motor activity 57/4302 151/18639 0.377483443708609 1.63549835129818 3.400232401628e-05 0.000561668018935588 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 57/4302 151/18639 0.377483443708609 1.63549835129818 3.400232401628e-05 0.000561668018935588 GO:0140849 ATP-dependent H2AZ histone chaperone activity 57/4302 151/18639 0.377483443708609 1.63549835129818 3.400232401628e-05 0.000561668018935588 GO:0019210 kinase inhibitor activity 38/4302 90/18639 0.422222222222222 1.82933519293352 4.15975315322616e-05 0.000678749965733732 GO:0015616 DNA translocase activity 57/4302 152/18639 0.375 1.62473849372385 4.23038399996154e-05 0.000681958288186571 GO:0140463 chromatin-protein adaptor activity 26/4302 54/18639 0.481481481481481 2.08608399194173 4.69460082099821e-05 0.000747782845059 GO:0003725 double-stranded RNA binding 33/4302 75/18639 0.44 1.90635983263598 4.86577603098733e-05 0.000757024224355936 GO:0044183 protein folding chaperone 33/4302 75/18639 0.44 1.90635983263598 4.86577603098733e-05 0.000757024224355936 GO:0061775 cohesin loader activity 57/4302 153/18639 0.372549019607843 1.61411928788252 5.24297556072427e-05 0.00080633348278725 GO:0016922 nuclear receptor binding 52/4302 137/18639 0.37956204379562 1.64450416882998 6.21115975056701e-05 0.000944378607529393 GO:0051082 unfolded protein binding 47/4302 121/18639 0.388429752066116 1.68292472077181 7.10255665273104e-05 0.00106777761812968 GO:0140658 ATP-dependent chromatin remodeler activity 58/4302 158/18639 0.367088607594937 1.59046131031195 7.33766854423732e-05 0.00109086672357661 GO:0000049 tRNA binding 34/4302 80/18639 0.425 1.84137029288703 8.83506066907047e-05 0.0012990451840897 GO:0019001 guanyl nucleotide binding 125/4302 400/18639 0.3125 1.35394874476987 9.24473527436181e-05 0.00133004901044044 GO:0032561 guanyl ribonucleotide binding 125/4302 400/18639 0.3125 1.35394874476987 9.24473527436181e-05 0.00133004901044044 GO:0070063 RNA polymerase binding 27/4302 59/18639 0.457627118644068 1.98273172115453 0.000102285368114631 0.00145593428231251 GO:0003689 DNA clamp loader activity 58/4302 160/18639 0.3625 1.57058054393305 0.000109599935332775 0.0015436285628974 GO:0005543 phospholipid binding 150/4302 497/18639 0.301810865191147 1.30763661466708 0.000130935594547735 0.00181370519847292 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 11/4302 16/18639 0.6875 2.97868723849372 0.000131486849216647 0.00181370519847292 GO:0004197 cysteine-type endopeptidase activity 36/4302 88/18639 0.409090909090909 1.77244199315329 0.000142749171700334 0.00194896318096986 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 27/4302 60/18639 0.45 1.94968619246862 0.000145373633416185 0.00196474668192783 GO:0008175 tRNA methyltransferase activity 18/4302 34/18639 0.529411764705882 2.29374846172779 0.000149086683952517 0.00199477983128467 GO:0004843 cysteine-type deubiquitinase activity 42/4302 108/18639 0.388888888888889 1.6849139934914 0.000162866735611153 0.00215026981574308 GO:0003714 transcription corepressor activity 70/4302 204/18639 0.343137254901961 1.48668881778653 0.000163921914204629 0.00215026981574308 GO:0101005 deubiquitinase activity 44/4302 115/18639 0.382608695652174 1.65770420229216 0.000178202790419908 0.00230637567787435 GO:0140030 modification-dependent protein binding 61/4302 173/18639 0.352601156069364 1.52769245652647 0.000180704944705457 0.00230637567787435 GO:0043539 protein serine/threonine kinase activator activity 31/4302 73/18639 0.424657534246575 1.83988651344071 0.000180993607008076 0.00230637567787435 GO:0016791 phosphatase activity 89/4302 273/18639 0.326007326007326 1.41247107146689 0.00018734313363504 0.00236476521512909 GO:0008173 RNA methyltransferase activity 29/4302 67/18639 0.432835820895522 1.87532005245738 0.000194094701016061 0.00242709074728494 GO:0140597 protein carrier chaperone 65/4302 188/18639 0.345744680851064 1.49798584527731 0.000215757022055363 0.00267298977324144 GO:1905394 retromer complex binding 8/4302 10/18639 0.8 3.46610878661088 0.000228167070586506 0.00280080312334629 GO:1901981 phosphatidylinositol phosphate binding 64/4302 185/18639 0.345945945945946 1.49885785366957 0.000235756721952673 0.00286765903611523 GO:0030145 manganese ion binding 29/4302 68/18639 0.426470588235294 1.84774181639183 0.000264466605534556 0.00318789475860573 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 11/4302 17/18639 0.647058823529412 2.80347034211174 0.000294650108751185 0.00352001647775969 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 13/4302 22/18639 0.590909090909091 2.56019399011031 0.000301119217493494 0.00353418871058153 GO:0140517 protein-RNA adaptor activity 13/4302 22/18639 0.590909090909091 2.56019399011031 0.000301119217493494 0.00353418871058153 GO:0019003 GDP binding 31/4302 75/18639 0.413333333333333 1.79082287308229 0.000323907688106104 0.00376859553639972 GO:0140311 protein sequestering activity 17/4302 33/18639 0.515151515151515 2.23196399137822 0.000348625622504944 0.00402121623199668 GO:0002039 p53 binding 29/4302 69/18639 0.420289855072464 1.8209629494876 0.00035657267060209 0.00407772848944954 GO:0017056 structural constituent of nuclear pore 14/4302 25/18639 0.56 2.42627615062761 0.000380356689431198 0.00431285805473681 GO:0000774 adenyl-nucleotide exchange factor activity 10/4302 15/18639 0.666666666666667 2.8884239888424 0.000396974038957299 0.00446345600104929 GO:0003727 single-stranded RNA binding 35/4302 89/18639 0.393258426966292 1.7038456113958 0.000431048253333133 0.00480618802466443 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 13/4302 23/18639 0.565217391304348 2.4488812079316 0.000546531772320519 0.00604346703607318 GO:0019209 kinase activator activity 52/4302 148/18639 0.351351351351351 1.52227750763316 0.000571755995461225 0.00627056985186164 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 11/4302 18/18639 0.611111111111111 2.6477219897722 0.000599596450486926 0.00652243943700412 GO:0004527 exonuclease activity 33/4302 84/18639 0.392857142857143 1.70210699342499 0.000633653887707246 0.00683732985284109 GO:0032404 mismatch repair complex binding 8/4302 11/18639 0.727272727272727 3.15100798782807 0.000666327589240042 0.00713237051522541 GO:0030295 protein kinase activator activity 49/4302 139/18639 0.352517985611511 1.52733210920803 0.00074498480428002 0.00784873754430446 GO:0140767 enzyme-substrate adaptor activity 49/4302 139/18639 0.352517985611511 1.52733210920803 0.00074498480428002 0.00784873754430446 GO:0051059 NF-kappaB binding 16/4302 32/18639 0.5 2.1663179916318 0.000794860476942996 0.00830877592304476 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 18/4302 38/18639 0.473684210526316 2.05230125523013 0.000864875963173874 0.00896122513019277 GO:0061650 ubiquitin-like protein conjugating enzyme activity 19/4302 41/18639 0.463414634146341 2.00780691907338 0.000877113344760557 0.00896122513019277 GO:0043014 alpha-tubulin binding 20/4302 44/18639 0.454545454545455 1.96937999239254 0.000877369575527094 0.00896122513019277 GO:0001671 ATPase activator activity 14/4302 27/18639 0.518518518518518 2.24655199132187 0.00106428506177029 0.0106526660961445 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 14/4302 27/18639 0.518518518518518 2.24655199132187 0.00106428506177029 0.0106526660961445 GO:0004518 nuclease activity 68/4302 209/18639 0.325358851674641 1.40966146823887 0.00106685893638518 0.0106526660961445 GO:0008187 poly-pyrimidine tract binding 15/4302 30/18639 0.5 2.1663179916318 0.00115441124629611 0.0113573694672368 GO:0032452 histone demethylase activity 15/4302 30/18639 0.5 2.1663179916318 0.00115441124629611 0.0113573694672368 GO:0008174 mRNA methyltransferase activity 9/4302 14/18639 0.642857142857143 2.78526598924088 0.00116480281785782 0.0113759574473998 GO:0046915 transition metal ion transmembrane transporter activity 20/4302 45/18639 0.444444444444444 1.9256159925616 0.00124002150188789 0.0120228171704783 GO:0005484 SNAP receptor activity 17/4302 36/18639 0.472222222222222 2.0459669920967 0.00124957335241683 0.0120266386341799 GO:0035198 miRNA binding 19/4302 42/18639 0.452380952380952 1.96000199242877 0.00125839268220119 0.0120266386341799 GO:0042393 histone binding 78/4302 247/18639 0.315789473684211 1.36820083682008 0.00127261975044979 0.0120763491212895 GO:0008408 3'-5' exonuclease activity 24/4302 58/18639 0.413793103448276 1.79281488962632 0.0014466902863693 0.0135361650570778 GO:0061980 regulatory RNA binding 24/4302 58/18639 0.413793103448276 1.79281488962632 0.0014466902863693 0.0135361650570778 GO:0140313 molecular sequestering activity 23/4302 55/18639 0.418181818181818 1.81182959300114 0.00152260503773579 0.0141200123953483 GO:0003713 transcription coactivator activity 80/4302 256/18639 0.3125 1.35394874476987 0.0015502864670594 0.0141200123953483 GO:0008170 N-methyltransferase activity 36/4302 98/18639 0.36734693877551 1.59158056528051 0.00156044788523375 0.0141200123953483 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 8/4302 12/18639 0.666666666666667 2.8884239888424 0.00159351410440776 0.0141200123953483 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 8/4302 12/18639 0.666666666666667 2.8884239888424 0.00159351410440776 0.0141200123953483 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 8/4302 12/18639 0.666666666666667 2.8884239888424 0.00159351410440776 0.0141200123953483 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 8/4302 12/18639 0.666666666666667 2.8884239888424 0.00159351410440776 0.0141200123953483 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 8/4302 12/18639 0.666666666666667 2.8884239888424 0.00159351410440776 0.0141200123953483 GO:0051787 misfolded protein binding 10/4302 17/18639 0.588235294117647 2.54860940191976 0.00161774208820201 0.0142403875921993 GO:0140104 molecular carrier activity 78/4302 249/18639 0.313253012048193 1.35721127186571 0.0016343709007493 0.0142927337594939 GO:0141052 histone H3 demethylase activity 14/4302 28/18639 0.5 2.1663179916318 0.0016796332963638 0.0145931776008751 GO:0140457 protein demethylase activity 15/4302 31/18639 0.483870967741935 2.09643676609529 0.00176326401514324 0.0151979855326697 GO:0004712 protein serine/threonine/tyrosine kinase activity 19/4302 43/18639 0.441860465116279 1.91442055074438 0.0017719624387866 0.0151979855326697 GO:0004532 RNA exonuclease activity 18/4302 40/18639 0.45 1.94968619246862 0.0018056606433166 0.0152532689779685 GO:0052866 phosphatidylinositol phosphate phosphatase activity 16/4302 34/18639 0.470588235294118 2.03888752153581 0.00180745214339788 0.0152532689779685 GO:0042578 phosphoric ester hydrolase activity 108/4302 363/18639 0.297520661157025 1.2890487222933 0.00181260819693348 0.0152532689779685 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/4302 10/18639 0.7 3.03284518828452 0.00212863093601065 0.0178006762023891 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 12/4302 23/18639 0.521739130434783 2.2605057303984 0.00226021243515493 0.0187831575926862 GO:0051213 dioxygenase activity 34/4302 93/18639 0.365591397849462 1.58397444549422 0.0022741939686212 0.0187831575926862 GO:0004721 phosphoprotein phosphatase activity 57/4302 175/18639 0.325714285714286 1.41120143454871 0.0025048292155844 0.0205611134383553 GO:0000175 3'-5'-RNA exonuclease activity 16/4302 35/18639 0.457142857142857 1.98063359234907 0.00262361028499687 0.0210203027624301 GO:0005154 epidermal growth factor receptor binding 16/4302 35/18639 0.457142857142857 1.98063359234907 0.00262361028499687 0.0210203027624301 GO:0061631 ubiquitin conjugating enzyme activity 16/4302 35/18639 0.457142857142857 1.98063359234907 0.00262361028499687 0.0210203027624301 GO:0140566 histone reader activity 16/4302 35/18639 0.457142857142857 1.98063359234907 0.00262361028499687 0.0210203027624301 GO:0038187 pattern recognition receptor activity 20/4302 48/18639 0.416666666666667 1.8052649930265 0.00317519035541466 0.0251384893227504 GO:0140693 molecular condensate scaffold activity 20/4302 48/18639 0.416666666666667 1.8052649930265 0.00317519035541466 0.0251384893227504 GO:0004386 helicase activity 51/4302 155/18639 0.329032258064516 1.4255770009448 0.00323847169943147 0.0254886772578783 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 8/4302 13/18639 0.615384615384615 2.66623752816221 0.00330578523623563 0.0258663195677384 GO:0004715 non-membrane spanning protein tyrosine kinase activity 19/4302 45/18639 0.422222222222222 1.82933519293352 0.00333742219742314 0.0259620401171637 GO:0043175 RNA polymerase core enzyme binding 18/4302 42/18639 0.428571428571429 1.85684399282726 0.00348781769695817 0.0268201153938508 GO:0051879 Hsp90 protein binding 18/4302 42/18639 0.428571428571429 1.85684399282726 0.00348781769695817 0.0268201153938508 GO:0035035 histone acetyltransferase binding 12/4302 24/18639 0.5 2.1663179916318 0.0035789806547384 0.0273638635202284 GO:0000993 RNA polymerase II complex binding 16/4302 36/18639 0.444444444444444 1.9256159925616 0.00372283983106092 0.0283020437156791 GO:0016763 pentosyltransferase activity 20/4302 49/18639 0.408163265306122 1.76842285031167 0.00421792633071736 0.0318846634491515 GO:0019902 phosphatase binding 60/4302 190/18639 0.315789473684211 1.36820083682008 0.00430673040589186 0.0323730633881085 GO:0004540 RNA nuclease activity 41/4302 121/18639 0.338842975206612 1.46808326705626 0.00436383238039642 0.0326190375696671 GO:0031593 polyubiquitin modification-dependent protein binding 23/4302 59/18639 0.389830508474576 1.68899368839089 0.0044598555716614 0.0331515930826831 GO:0140537 transcription regulator activator activity 7/4302 11/18639 0.636363636363636 2.75713198934956 0.00468766179285923 0.0346524391096445 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 17/4302 40/18639 0.425 1.84137029288703 0.00495984786573238 0.036463057386538 GO:0004709 MAP kinase kinase kinase activity 12/4302 25/18639 0.48 2.07966527196653 0.0054525421493676 0.0393483269661947 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 12/4302 25/18639 0.48 2.07966527196653 0.0054525421493676 0.0393483269661947 GO:0046966 nuclear thyroid hormone receptor binding 13/4302 28/18639 0.464285714285714 2.01158099222953 0.00551551916555354 0.0393483269661947 GO:0051019 mitogen-activated protein kinase binding 13/4302 28/18639 0.464285714285714 2.01158099222953 0.00551551916555354 0.0393483269661947 GO:0051537 2 iron, 2 sulfur cluster binding 13/4302 28/18639 0.464285714285714 2.01158099222953 0.00551551916555354 0.0393483269661947 GO:0032813 tumor necrosis factor receptor superfamily binding 20/4302 50/18639 0.4 1.73305439330544 0.00552876343022766 0.0393483269661947 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 23/4302 60/18639 0.383333333333333 1.66084379358438 0.00567898008869319 0.0402035733263042 GO:0003724 RNA helicase activity 28/4302 77/18639 0.363636363636364 1.57550399391404 0.00577171585733584 0.0406450306163966 GO:0019763 immunoglobulin receptor activity 8/4302 14/18639 0.571428571428571 2.47579199043634 0.00616042846073937 0.0429304858357775 GO:0030983 mismatched DNA binding 8/4302 14/18639 0.571428571428571 2.47579199043634 0.00616042846073937 0.0429304858357775 GO:0008276 protein methyltransferase activity 33/4302 95/18639 0.347368421052632 1.50502092050209 0.0064984386206188 0.0450513516807666 GO:0003925 G protein activity 21/4302 54/18639 0.388888888888889 1.6849139934914 0.00663582788182662 0.0457666892055877 GO:0001727 lipid kinase activity 17/4302 41/18639 0.414634146341463 1.79645882232881 0.00667932563857011 0.0458304497661888 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 42/4302 128/18639 0.328125 1.42164618200837 0.00743751277979931 0.0507724086702627 GO:0005548 phospholipid transporter activity 25/4302 68/18639 0.367647058823529 1.59288087619985 0.00751348922853348 0.0510307034912578 GO:0070717 poly-purine tract binding 14/4302 32/18639 0.4375 1.89552824267782 0.00769073255522462 0.0515984082190155 GO:0032266 phosphatidylinositol-3-phosphate binding 19/4302 48/18639 0.395833333333333 1.71500174337517 0.00770134130494818 0.0515984082190155 GO:0052745 inositol phosphate phosphatase activity 10/4302 20/18639 0.5 2.1663179916318 0.00771276654992758 0.0515984082190155 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/4302 29/18639 0.448275862068966 1.94221613042851 0.00791392684931908 0.0524199709128165 GO:0097472 cyclin-dependent protein kinase activity 13/4302 29/18639 0.448275862068966 1.94221613042851 0.00791392684931908 0.0524199709128165 GO:0003887 DNA-directed DNA polymerase activity 11/4302 23/18639 0.478260869565217 2.0721302528652 0.00798153361338049 0.0526073496290793 GO:0052742 phosphatidylinositol kinase activity 12/4302 26/18639 0.461538461538462 1.99967814612166 0.0080271111037135 0.0526484051802386 GO:0008186 ATP-dependent activity, acting on RNA 28/4302 79/18639 0.354430379746835 1.53561781685292 0.00857174615965196 0.0559463237151918 GO:0035591 signaling adaptor activity 42/4302 129/18639 0.325581395348837 1.41062566896954 0.00861642682406763 0.0559649470417596 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 40/4302 122/18639 0.327868852459016 1.42053638795528 0.00896434514923132 0.057943448355901 GO:0016423 tRNA (guanine) methyltransferase activity 7/4302 12/18639 0.583333333333333 2.5273709902371 0.00901946855669127 0.0580194660041006 GO:0017124 SH3 domain binding 38/4302 115/18639 0.330434782608696 1.43165362925232 0.00929700385521085 0.0595186179821632 GO:0050700 CARD domain binding 8/4302 15/18639 0.533333333333333 2.31073919107392 0.0105534370030602 0.0669217948345715 GO:0140776 protein-containing complex destabilizing activity 8/4302 15/18639 0.533333333333333 2.31073919107392 0.0105534370030602 0.0669217948345715 GO:0016278 lysine N-methyltransferase activity 25/4302 70/18639 0.357142857142857 1.54736999402271 0.0112988838802299 0.0711905809360146 GO:0004706 JUN kinase kinase kinase activity 9/4302 18/18639 0.5 2.1663179916318 0.0113862364127856 0.0711905809360146 GO:0008525 phosphatidylcholine transporter activity 9/4302 18/18639 0.5 2.1663179916318 0.0113862364127856 0.0711905809360146 GO:0008266 poly(U) RNA binding 12/4302 27/18639 0.444444444444444 1.9256159925616 0.0114611422627976 0.0713256202215034 GO:0048156 tau protein binding 17/4302 43/18639 0.395348837209302 1.71290259803445 0.0115475279024208 0.0715305200622174 GO:0000149 SNARE binding 35/4302 106/18639 0.330188679245283 1.4305873529644 0.0123370511508734 0.0755451996100218 GO:0042054 histone methyltransferase activity 24/4302 67/18639 0.358208955223881 1.55198900893024 0.0123905389790458 0.0755451996100218 GO:0030331 nuclear estrogen receptor binding 16/4302 40/18639 0.4 1.73305439330544 0.0124214827460424 0.0755451996100218 GO:0032451 demethylase activity 16/4302 40/18639 0.4 1.73305439330544 0.0124214827460424 0.0755451996100218 GO:0045296 cadherin binding 95/4302 334/18639 0.284431137724551 1.23233658206599 0.0125737972498567 0.0761255236213045 GO:0005381 iron ion transmembrane transporter activity 6/4302 10/18639 0.6 2.59958158995816 0.0132255084574799 0.0797104969194061 GO:0004722 protein serine/threonine phosphatase activity 34/4302 103/18639 0.330097087378641 1.43019051874721 0.0135645405676179 0.0813872434057072 GO:0090482 vitamin transmembrane transporter activity 14/4302 34/18639 0.411764705882353 1.78402658134383 0.0142197893951905 0.0849378491552004 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 20/4302 54/18639 0.37037037037037 1.60467999380133 0.0144765415005626 0.086087166790012 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 28/4302 82/18639 0.341463414634146 1.47943667721196 0.0147738906381206 0.0874666622734752 GO:1990841 promoter-specific chromatin binding 24/4302 68/18639 0.352941176470588 1.52916564115186 0.0150507479338708 0.088615545631263 GO:0070273 phosphatidylinositol-4-phosphate binding 13/4302 31/18639 0.419354838709677 1.81691186394925 0.0151004068788699 0.088615545631263 GO:0004535 poly(A)-specific ribonuclease activity 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0035325 Toll-like receptor binding 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0046975 histone H3K36 methyltransferase activity 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0051011 microtubule minus-end binding 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0140852 histone ubiquitin ligase activity 7/4302 13/18639 0.538461538461538 2.33295783714194 0.0156854324305562 0.0896884982567699 GO:0016830 carbon-carbon lyase activity 19/4302 51/18639 0.372549019607843 1.61411928788252 0.0158184296365771 0.0898794984207078 GO:0001221 transcription coregulator binding 37/4302 115/18639 0.321739130434783 1.39397853374568 0.0158862414353718 0.0898794984207078 GO:0097718 disordered domain specific binding 12/4302 28/18639 0.428571428571429 1.85684399282726 0.0159203595857308 0.0898794984207078 GO:0042169 SH2 domain binding 16/4302 41/18639 0.390243902439024 1.69078477395653 0.0160964632948247 0.0904918818843508 GO:0046332 SMAD binding 27/4302 79/18639 0.341772151898734 1.48077432339389 0.0162580808903394 0.0910180428086784 GO:0120013 lipid transfer activity 23/4302 65/18639 0.353846153846154 1.53308657869327 0.0165396144341999 0.0922083504706643 GO:0004707 MAP kinase activity 8/4302 16/18639 0.5 2.1663179916318 0.0168912080657473 0.0930059110780653 GO:0015923 mannosidase activity 8/4302 16/18639 0.5 2.1663179916318 0.0168912080657473 0.0930059110780653 GO:0043023 ribosomal large subunit binding 8/4302 16/18639 0.5 2.1663179916318 0.0168912080657473 0.0930059110780653 GO:0140036 ubiquitin-modified protein reader activity 9/4302 19/18639 0.473684210526316 2.05230125523013 0.0172696582741271 0.0943442071409756 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 18/4302 48/18639 0.375 1.62473849372385 0.0172752845661727 0.0943442071409756 GO:0042887 amide transmembrane transporter activity 15/4302 38/18639 0.394736842105263 1.7102510460251 0.0174057600543669 0.0946703534664347 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 28/4302 83/18639 0.337349397590361 1.4616121389323 0.0174990380059594 0.0947923597245895 GO:0016279 protein-lysine N-methyltransferase activity 24/4302 69/18639 0.347826086956522 1.5070038202656 0.018144605056636 0.0978930708297538 GO:0043015 gamma-tubulin binding 14/4302 35/18639 0.4 1.73305439330544 0.0187704080672105 0.100862674674408 GO:0140303 intramembrane lipid transporter activity 17/4302 45/18639 0.377777777777778 1.63677359367736 0.0188530332409322 0.100901433905469 GO:0004725 protein tyrosine phosphatase activity 32/4302 98/18639 0.326530612244898 1.41473828024934 0.0191059706770671 0.101847764007633 GO:0106222 lncRNA binding 12/4302 29/18639 0.413793103448276 1.79281488962632 0.0215719591643742 0.11453683080132 GO:0003697 single-stranded DNA binding 38/4302 121/18639 0.31404958677686 1.36066254019849 0.0217345953728568 0.114944223750523 GO:0033192 calmodulin-dependent protein phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0140791 histone H2AXS140 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:1990439 MAP kinase serine/threonine phosphatase activity 27/4302 81/18639 0.333333333333333 1.4442119944212 0.0227082246383318 0.116412278030988 GO:0004529 DNA exonuclease activity 11/4302 26/18639 0.423076923076923 1.83303830061152 0.0229228514821879 0.116618917426492 GO:0050681 nuclear androgen receptor binding 11/4302 26/18639 0.423076923076923 1.83303830061152 0.0229228514821879 0.116618917426492 GO:0005225 volume-sensitive anion channel activity 6/4302 11/18639 0.545454545454545 2.36325599087105 0.0234709244550248 0.117618340527428 GO:0019864 IgG binding 6/4302 11/18639 0.545454545454545 2.36325599087105 0.0234709244550248 0.117618340527428 GO:0032050 clathrin heavy chain binding 6/4302 11/18639 0.545454545454545 2.36325599087105 0.0234709244550248 0.117618340527428 GO:0140031 phosphorylation-dependent protein binding 6/4302 11/18639 0.545454545454545 2.36325599087105 0.0234709244550248 0.117618340527428 GO:0030291 protein serine/threonine kinase inhibitor activity 17/4302 46/18639 0.369565217391304 1.6011915590322 0.0236281327444163 0.117964334373243 GO:0001098 basal transcription machinery binding 21/4302 60/18639 0.35 1.51642259414226 0.0242282924799552 0.120064649400667 GO:0001099 basal RNA polymerase II transcription machinery binding 21/4302 60/18639 0.35 1.51642259414226 0.0242282924799552 0.120064649400667 GO:0043024 ribosomal small subunit binding 9/4302 20/18639 0.45 1.94968619246862 0.0250889333211995 0.123107897458755 GO:0004705 JUN kinase activity 7/4302 14/18639 0.5 2.1663179916318 0.0252104364003729 0.123107897458755 GO:0005545 1-phosphatidylinositol binding 7/4302 14/18639 0.5 2.1663179916318 0.0252104364003729 0.123107897458755 GO:0046030 inositol trisphosphate phosphatase activity 7/4302 14/18639 0.5 2.1663179916318 0.0252104364003729 0.123107897458755 GO:0004659 prenyltransferase activity 8/4302 17/18639 0.470588235294118 2.03888752153581 0.0255604327694643 0.123465195110264 GO:0070403 NAD+ binding 8/4302 17/18639 0.470588235294118 2.03888752153581 0.0255604327694643 0.123465195110264 GO:1990226 histone methyltransferase binding 8/4302 17/18639 0.470588235294118 2.03888752153581 0.0255604327694643 0.123465195110264 GO:0019239 deaminase activity 13/4302 33/18639 0.393939393939394 1.70679599340687 0.0264120559886073 0.127119895369628 GO:0015605 organophosphate ester transmembrane transporter activity 18/4302 50/18639 0.36 1.5597489539749 0.0265945331257371 0.127125584495225 GO:0033549 MAP kinase phosphatase activity 27/4302 82/18639 0.329268292682927 1.42659965302582 0.0266032613293445 0.127125584495225 GO:0016504 peptidase activator activity 20/4302 57/18639 0.350877192982456 1.52022315202232 0.0267009273413555 0.127138223426098 GO:0015036 disulfide oxidoreductase activity 15/4302 40/18639 0.375 1.62473849372385 0.0283652576998101 0.133698651082392 GO:0071949 FAD binding 15/4302 40/18639 0.375 1.62473849372385 0.0283652576998101 0.133698651082392 GO:0015215 nucleotide transmembrane transporter activity 12/4302 30/18639 0.4 1.73305439330544 0.0285783364794948 0.133698651082392 GO:0031624 ubiquitin conjugating enzyme binding 12/4302 30/18639 0.4 1.73305439330544 0.0285783364794948 0.133698651082392 GO:0070566 adenylyltransferase activity 12/4302 30/18639 0.4 1.73305439330544 0.0285783364794948 0.133698651082392 GO:0140938 histone H3 methyltransferase activity 17/4302 47/18639 0.361702127659574 1.56712365352088 0.0292625429884312 0.136422587172547 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 11/4302 27/18639 0.407407407407407 1.76514799318147 0.0308027765705186 0.143104566150534 GO:0008135 translation factor activity, RNA binding 27/4302 83/18639 0.325301204819277 1.409411705399 0.0309927975745483 0.143489145864172 GO:0001046 core promoter sequence-specific DNA binding 16/4302 44/18639 0.363636363636364 1.57550399391404 0.0322032577697117 0.148579168606463 GO:0051536 iron-sulfur cluster binding 25/4302 76/18639 0.328947368421053 1.42520920502092 0.0323734054349703 0.148850915711307 GO:0140612 DNA damage sensor activity 10/4302 24/18639 0.416666666666667 1.8052649930265 0.0330196304674552 0.15130227933375 GO:0140789 histone phosphatase activity 41/4302 136/18639 0.301470588235294 1.30616231848388 0.0341636723102419 0.156010216897965 GO:0005123 death receptor binding 9/4302 21/18639 0.428571428571429 1.85684399282726 0.0351162293023978 0.158734847319623 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 9/4302 21/18639 0.428571428571429 1.85684399282726 0.0351162293023978 0.158734847319623 GO:0051010 microtubule plus-end binding 9/4302 21/18639 0.428571428571429 1.85684399282726 0.0351162293023978 0.158734847319623 GO:0019903 protein phosphatase binding 43/4302 144/18639 0.298611111111111 1.29377324500232 0.0356630628327725 0.16066389922643 GO:0017018 myosin phosphatase activity 27/4302 84/18639 0.321428571428571 1.39263299462044 0.0359120162797795 0.160703270175067 GO:0180051 translation factor activity 27/4302 84/18639 0.321428571428571 1.39263299462044 0.0359120162797795 0.160703270175067 GO:0008409 5'-3' exonuclease activity 8/4302 18/18639 0.444444444444444 1.9256159925616 0.0368997898548072 0.164165309510009 GO:0051540 metal cluster binding 25/4302 77/18639 0.324675324675325 1.4066999945661 0.0377293144101633 0.164165309510009 GO:0004875 complement receptor activity 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:0005095 GTPase inhibitor activity 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:0097677 STAT family protein binding 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:1990247 N6-methyladenosine-containing RNA reader activity 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:1990459 transferrin receptor binding 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:1990817 poly(A) RNA polymerase activity 6/4302 12/18639 0.5 2.1663179916318 0.0379223803533582 0.164165309510009 GO:0004559 alpha-mannosidase activity 7/4302 15/18639 0.466666666666667 2.02189679218968 0.0380353108730216 0.164165309510009 GO:0061578 K63-linked deubiquitinase activity 7/4302 15/18639 0.466666666666667 2.02189679218968 0.0380353108730216 0.164165309510009 GO:0120283 protein serine/threonine kinase binding 7/4302 15/18639 0.466666666666667 2.02189679218968 0.0380353108730216 0.164165309510009 GO:0036002 pre-mRNA binding 20/4302 59/18639 0.338983050847458 1.46869016381817 0.0383902462918518 0.165164467969446 GO:0016829 lyase activity 57/4302 200/18639 0.285 1.23480125523013 0.0429212147746713 0.183537309405832 GO:0034061 DNA polymerase activity 13/4302 35/18639 0.371428571428571 1.60926479378362 0.0429351104962822 0.183537309405832 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 10/4302 25/18639 0.4 1.73305439330544 0.0439521791284851 0.186692113250518 GO:0017025 TBP-class protein binding 10/4302 25/18639 0.4 1.73305439330544 0.0439521791284851 0.186692113250518 GO:0051219 phosphoprotein binding 29/4302 93/18639 0.311827956989247 1.35103702703919 0.0446707801255422 0.189143999392328 GO:0140296 general transcription initiation factor binding 18/4302 53/18639 0.339622641509434 1.47146127733481 0.0470141221619992 0.198438156002381 GO:0120015 sterol transfer activity 12/4302 32/18639 0.375 1.62473849372385 0.047243030482373 0.198777279199418 GO:0050660 flavin adenine dinucleotide binding 27/4302 86/18639 0.313953488372093 1.36024618079206 0.0474741067305884 0.19894050691515 GO:0140035 ubiquitin-like protein reader activity 9/4302 22/18639 0.409090909090909 1.77244199315329 0.0475791944789597 0.19894050691515 GO:0004536 DNA nuclease activity 21/4302 64/18639 0.328125 1.42164618200837 0.0482779676778083 0.201233397984136 GO:0032934 sterol binding 22/4302 68/18639 0.323529411764706 1.40173517105587 0.0508969961665267 0.210688681265077 GO:0003756 protein disulfide isomerase activity 8/4302 19/18639 0.421052631578947 1.82426778242678 0.0511762491862108 0.210688681265077 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/4302 19/18639 0.421052631578947 1.82426778242678 0.0511762491862108 0.210688681265077 GO:1990380 K48-linked deubiquitinase activity 8/4302 19/18639 0.421052631578947 1.82426778242678 0.0511762491862108 0.210688681265077 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 11/4302 29/18639 0.379310344827586 1.64341364882412 0.0519585081819445 0.213253018243686 GO:0042626 ATPase-coupled transmembrane transporter activity 30/4302 98/18639 0.306122448979592 1.32631713773375 0.0523077358761509 0.214029818355626 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 7/4302 16/18639 0.4375 1.89552824267782 0.0544807241675683 0.220227217329929 GO:0070411 I-SMAD binding 7/4302 16/18639 0.4375 1.89552824267782 0.0544807241675683 0.220227217329929 GO:0140327 flippase activity 7/4302 16/18639 0.4375 1.89552824267782 0.0544807241675683 0.220227217329929 GO:0140328 floppase activity 7/4302 16/18639 0.4375 1.89552824267782 0.0544807241675683 0.220227217329929 GO:0038024 cargo receptor activity 21/4302 65/18639 0.323076923076923 1.39977470228516 0.0563144937751801 0.222908383888983 GO:0035673 oligopeptide transmembrane transporter activity 6/4302 13/18639 0.461538461538462 1.99967814612166 0.0569826214300458 0.222908383888983 GO:0046974 histone H3K9 methyltransferase activity 6/4302 13/18639 0.461538461538462 1.99967814612166 0.0569826214300458 0.222908383888983 GO:0008198 ferrous iron binding 10/4302 26/18639 0.384615384615385 1.66639845510138 0.0570955089074208 0.222908383888983 GO:0070412 R-SMAD binding 10/4302 26/18639 0.384615384615385 1.66639845510138 0.0570955089074208 0.222908383888983 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0004445 inositol-polyphosphate 5-phosphatase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0015658 branched-chain amino acid transmembrane transporter activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0016303 1-phosphatidylinositol-3-kinase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0016427 tRNA (cytidine) methyltransferase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0051864 histone H3K36 demethylase activity 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0070513 death domain binding 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0099122 RNA polymerase II C-terminal domain binding 5/4302 10/18639 0.5 2.1663179916318 0.0576429752059702 0.222908383888983 GO:0016853 isomerase activity 51/4302 180/18639 0.283333333333333 1.22758019525802 0.0581273011318899 0.224133512721812 GO:0071889 14-3-3 protein binding 12/4302 33/18639 0.363636363636364 1.57550399391404 0.0591464444788108 0.226756282844266 GO:0140416 transcription regulator inhibitor activity 12/4302 33/18639 0.363636363636364 1.57550399391404 0.0591464444788108 0.226756282844266 GO:0016407 acetyltransferase activity 29/4302 96/18639 0.302083333333333 1.30881711994421 0.0648355599430146 0.247857083439296 GO:0000339 RNA cap binding 8/4302 20/18639 0.4 1.73305439330544 0.0685677930962184 0.259163014584012 GO:0016505 peptidase activator activity involved in apoptotic process 8/4302 20/18639 0.4 1.73305439330544 0.0685677930962184 0.259163014584012 GO:0030742 GTP-dependent protein binding 8/4302 20/18639 0.4 1.73305439330544 0.0685677930962184 0.259163014584012 GO:0140664 ATP-dependent DNA damage sensor activity 8/4302 20/18639 0.4 1.73305439330544 0.0685677930962184 0.259163014584012 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 27/4302 89/18639 0.303370786516854 1.3143951859339 0.0695788919372591 0.261507183741721 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 27/4302 89/18639 0.303370786516854 1.3143951859339 0.0695788919372591 0.261507183741721 GO:0003684 damaged DNA binding 23/4302 74/18639 0.310810810810811 1.34663010290625 0.0703500714181272 0.263664973550292 GO:1901682 sulfur compound transmembrane transporter activity 20/4302 63/18639 0.317460317460317 1.37543999468686 0.072245494459182 0.269391501550465 GO:0015035 protein-disulfide reductase activity 12/4302 34/18639 0.352941176470588 1.52916564115186 0.0728846962341319 0.269391501550465 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 12/4302 34/18639 0.352941176470588 1.52916564115186 0.0728846962341319 0.269391501550465 GO:0016831 carboxy-lyase activity 12/4302 34/18639 0.352941176470588 1.52916564115186 0.0728846962341319 0.269391501550465 GO:0030332 cyclin binding 12/4302 34/18639 0.352941176470588 1.52916564115186 0.0728846962341319 0.269391501550465 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 7/4302 17/18639 0.411764705882353 1.78402658134383 0.074724928146241 0.273923161259371 GO:0015278 intracellularly gated calcium channel activity 7/4302 17/18639 0.411764705882353 1.78402658134383 0.074724928146241 0.273923161259371 GO:0036041 long-chain fatty acid binding 7/4302 17/18639 0.411764705882353 1.78402658134383 0.074724928146241 0.273923161259371 GO:0141110 transporter inhibitor activity 15/4302 45/18639 0.333333333333333 1.4442119944212 0.0764434941078359 0.279457363705695 GO:0140793 histone H2AXY142 phosphatase activity 27/4302 90/18639 0.3 1.29979079497908 0.0783184557986355 0.283378000834935 GO:0019208 phosphatase regulator activity 34/4302 117/18639 0.290598290598291 1.25905661052105 0.0789276842061966 0.283378000834935 GO:0043531 ADP binding 13/4302 38/18639 0.342105263157895 1.48221757322176 0.0793872159597787 0.283378000834935 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 9/4302 24/18639 0.375 1.62473849372385 0.08042456718422 0.283378000834935 GO:0042625 ATPase-coupled ion transmembrane transporter activity 9/4302 24/18639 0.375 1.62473849372385 0.08042456718422 0.283378000834935 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 9/4302 24/18639 0.375 1.62473849372385 0.08042456718422 0.283378000834935 GO:0046961 proton-transporting ATPase activity, rotational mechanism 9/4302 24/18639 0.375 1.62473849372385 0.08042456718422 0.283378000834935 GO:0008474 palmitoyl-(protein) hydrolase activity 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0019992 diacylglycerol binding 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0032454 histone H3K9 demethylase activity 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0070742 C2H2 zinc finger domain binding 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0098599 palmitoyl hydrolase activity 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0098847 sequence-specific single stranded DNA binding 6/4302 14/18639 0.428571428571429 1.85684399282726 0.0808117602023006 0.283378000834935 GO:0001222 transcription corepressor binding 16/4302 49/18639 0.326530612244898 1.41473828024934 0.0810277585812525 0.283378000834935 GO:0005164 tumor necrosis factor receptor binding 11/4302 31/18639 0.354838709677419 1.53738696180321 0.0811164232584307 0.283378000834935 GO:0072349 modified amino acid transmembrane transporter activity 11/4302 31/18639 0.354838709677419 1.53738696180321 0.0811164232584307 0.283378000834935 GO:0048487 beta-tubulin binding 14/4302 42/18639 0.333333333333333 1.4442119944212 0.0851159842083106 0.293201367462831 GO:0016860 intramolecular oxidoreductase activity 17/4302 53/18639 0.320754716981132 1.38971342859398 0.0851302584118654 0.293201367462831 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0004143 ATP-dependent diacylglycerol kinase activity 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0005536 D-glucose binding 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0008526 phosphatidylinositol transfer activity 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0015173 aromatic amino acid transmembrane transporter activity 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0016176 superoxide-generating NADPH oxidase activator activity 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0019107 myristoyltransferase activity 5/4302 11/18639 0.454545454545455 1.96937999239254 0.0861196841650916 0.293201367462831 GO:0015932 nucleobase-containing compound transmembrane transporter activity 18/4302 57/18639 0.315789473684211 1.36820083682008 0.0888058429114654 0.301579233034367 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/4302 21/18639 0.380952380952381 1.65052799362423 0.0891533708154925 0.301992937091466 GO:0030276 clathrin binding 15/4302 46/18639 0.326086956521739 1.412816081499 0.0901722940796102 0.304673054238683 GO:0005319 lipid transporter activity 49/4302 178/18639 0.275280898876405 1.19269192797706 0.0942217264826287 0.317553325022059 GO:0008080 N-acetyltransferase activity 21/4302 69/18639 0.304347826086957 1.3186283427324 0.0977213189216201 0.327411345543777 GO:0015485 cholesterol binding 17/4302 54/18639 0.314814814814815 1.36397799473113 0.0986054994341093 0.327411345543777 GO:0000900 mRNA regulatory element binding translation repressor activity 7/4302 18/18639 0.388888888888889 1.6849139934914 0.0987954706953353 0.327411345543777 GO:0070628 proteasome binding 7/4302 18/18639 0.388888888888889 1.6849139934914 0.0987954706953353 0.327411345543777 GO:0008378 galactosyltransferase activity 11/4302 32/18639 0.34375 1.48934361924686 0.0988596289982706 0.327411345543777 GO:0022884 macromolecule transmembrane transporter activity 11/4302 32/18639 0.34375 1.48934361924686 0.0988596289982706 0.327411345543777 GO:0043425 bHLH transcription factor binding 11/4302 32/18639 0.34375 1.48934361924686 0.0988596289982706 0.327411345543777 GO:0070851 growth factor receptor binding 39/4302 139/18639 0.280575539568345 1.21563167875741 0.0991656231740753 0.327613836560278 GO:0008375 acetylglucosaminyltransferase activity 14/4302 43/18639 0.325581395348837 1.41062566896954 0.100494562123025 0.330215408197883 GO:0008139 nuclear localization sequence binding 9/4302 25/18639 0.36 1.5597489539749 0.100940285465571 0.330215408197883 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 9/4302 25/18639 0.36 1.5597489539749 0.100940285465571 0.330215408197883 GO:0120020 cholesterol transfer activity 9/4302 25/18639 0.36 1.5597489539749 0.100940285465571 0.330215408197883 GO:0001618 virus receptor activity 24/4302 81/18639 0.296296296296296 1.28374399504107 0.104193973709355 0.340028138592967 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 71/4302 268/18639 0.264925373134328 1.14782520452133 0.104649614333242 0.340684145931575 GO:0140359 ABC-type transporter activity 15/4302 47/18639 0.319148936170213 1.38275616487136 0.105357097786357 0.341326384595993 GO:1990518 single-stranded 3'-5' DNA helicase activity 15/4302 47/18639 0.319148936170213 1.38275616487136 0.105357097786357 0.341326384595993 GO:0044390 ubiquitin-like protein conjugating enzyme binding 12/4302 36/18639 0.333333333333333 1.4442119944212 0.106043546121968 0.342720446162303 GO:0005041 low-density lipoprotein particle receptor activity 6/4302 15/18639 0.4 1.73305439330544 0.109329393088486 0.349958679311949 GO:0034483 heparan sulfate sulfotransferase activity 6/4302 15/18639 0.4 1.73305439330544 0.109329393088486 0.349958679311949 GO:0042809 nuclear vitamin D receptor binding 6/4302 15/18639 0.4 1.73305439330544 0.109329393088486 0.349958679311949 GO:0048531 beta-1,3-galactosyltransferase activity 6/4302 15/18639 0.4 1.73305439330544 0.109329393088486 0.349958679311949 GO:0003678 DNA helicase activity 22/4302 74/18639 0.297297297297297 1.28808096799729 0.112703176111515 0.357148079301259 GO:0008649 rRNA methyltransferase activity 8/4302 22/18639 0.363636363636364 1.57550399391404 0.112910043007797 0.357148079301259 GO:0033691 sialic acid binding 8/4302 22/18639 0.363636363636364 1.57550399391404 0.112910043007797 0.357148079301259 GO:0050321 tau-protein kinase activity 8/4302 22/18639 0.363636363636364 1.57550399391404 0.112910043007797 0.357148079301259 GO:0070034 telomerase RNA binding 8/4302 22/18639 0.363636363636364 1.57550399391404 0.112910043007797 0.357148079301259 GO:0140272 exogenous protein binding 24/4302 82/18639 0.292682926829268 1.26808858046739 0.116412066061199 0.367094565177187 GO:0045309 protein phosphorylated amino acid binding 18/4302 59/18639 0.305084745762712 1.32182114743635 0.1166149218081 0.367094565177187 GO:0001217 DNA-binding transcription repressor activity 73/4302 278/18639 0.262589928057554 1.13770657114476 0.116877641827714 0.367094565177187 GO:0016248 channel inhibitor activity 14/4302 44/18639 0.318181818181818 1.37856599467478 0.117454442008593 0.368042256223648 GO:0015631 tubulin binding 99/4302 385/18639 0.257142857142857 1.11410639569635 0.120093694082338 0.369086931804754 GO:0000340 RNA 7-methylguanosine cap binding 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0000995 RNA polymerase III general transcription initiation factor activity 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0004126 cytidine deaminase activity 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0035197 siRNA binding 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0035251 UDP-glucosyltransferase activity 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0035259 nuclear glucocorticoid receptor binding 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0043047 single-stranded telomeric DNA binding 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 5/4302 12/18639 0.416666666666667 1.8052649930265 0.120546329744901 0.369086931804754 GO:0016879 ligase activity, forming carbon-nitrogen bonds 15/4302 48/18639 0.3125 1.35394874476987 0.12199715639771 0.371827324054979 GO:0043138 3'-5' DNA helicase activity 15/4302 48/18639 0.3125 1.35394874476987 0.12199715639771 0.371827324054979 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 9/4302 26/18639 0.346153846153846 1.49975860959125 0.124152225996357 0.372866937703088 GO:0008143 poly(A) binding 9/4302 26/18639 0.346153846153846 1.49975860959125 0.124152225996357 0.372866937703088 GO:0015216 purine nucleotide transmembrane transporter activity 9/4302 26/18639 0.346153846153846 1.49975860959125 0.124152225996357 0.372866937703088 GO:0070006 metalloaminopeptidase activity 9/4302 26/18639 0.346153846153846 1.49975860959125 0.124152225996357 0.372866937703088 GO:0120014 phospholipid transfer activity 9/4302 26/18639 0.346153846153846 1.49975860959125 0.124152225996357 0.372866937703088 GO:0140299 molecular sensor activity 21/4302 71/18639 0.295774647887324 1.28148388237374 0.124264840891745 0.372866937703088 GO:0005126 cytokine receptor binding 72/4302 275/18639 0.261818181818182 1.13436287561811 0.124288979234363 0.372866937703088 GO:0016757 glycosyltransferase activity 70/4302 267/18639 0.262172284644195 1.13589707426386 0.125400904071647 0.375361095409091 GO:0005346 purine ribonucleotide transmembrane transporter activity 7/4302 19/18639 0.368421052631579 1.59623430962343 0.126573349908991 0.375510293078115 GO:0046624 sphingolipid transporter activity 7/4302 19/18639 0.368421052631579 1.59623430962343 0.126573349908991 0.375510293078115 GO:0097001 ceramide binding 7/4302 19/18639 0.368421052631579 1.59623430962343 0.126573349908991 0.375510293078115 GO:0120227 acyl-CoA binding 7/4302 19/18639 0.368421052631579 1.59623430962343 0.126573349908991 0.375510293078115 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 13/4302 41/18639 0.317073170731707 1.37376262883968 0.131157724379282 0.388250077919202 GO:0035925 mRNA 3'-UTR AU-rich region binding 10/4302 30/18639 0.333333333333333 1.4442119944212 0.133227455189899 0.393506258375462 GO:0019888 protein phosphatase regulator activity 30/4302 107/18639 0.280373831775701 1.2147577523169 0.135254301434116 0.398612897178077 GO:0016874 ligase activity 45/4302 167/18639 0.269461077844311 1.16747676195726 0.136547487463895 0.401460620696967 GO:0140223 general transcription initiation factor activity 20/4302 68/18639 0.294117647058824 1.27430470095988 0.137074956684302 0.401460620696967 GO:0004519 endonuclease activity 35/4302 127/18639 0.275590551181102 1.19403353869469 0.137120705275422 0.401460620696967 GO:0000295 adenine nucleotide transmembrane transporter activity 8/4302 23/18639 0.347826086956522 1.5070038202656 0.139716617457058 0.407278505789856 GO:0140102 catalytic activity, acting on a rRNA 8/4302 23/18639 0.347826086956522 1.5070038202656 0.139716617457058 0.407278505789856 GO:0140034 methylation-dependent protein binding 22/4302 76/18639 0.289473684210526 1.25418410041841 0.140687169541226 0.407527279147982 GO:0000062 fatty-acyl-CoA binding 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0005521 lamin binding 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0008296 3'-5'-DNA exonuclease activity 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0015562 efflux transmembrane transporter activity 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0022858 alanine transmembrane transporter activity 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 6/4302 16/18639 0.375 1.62473849372385 0.142238594441037 0.407527279147982 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 122/4302 484/18639 0.252066115702479 1.09211072305405 0.142549640303881 0.407545766509812 GO:1901505 carbohydrate derivative transmembrane transporter activity 16/4302 53/18639 0.30188679245283 1.30796557985316 0.143564889685646 0.409573182088262 GO:0031490 chromatin DNA binding 35/4302 128/18639 0.2734375 1.18470515167364 0.148608877944189 0.423061018487926 GO:0005385 zinc ion transmembrane transporter activity 9/4302 27/18639 0.333333333333333 1.4442119944212 0.149947427971147 0.425965304937145 GO:0001614 purinergic nucleotide receptor activity 7/4302 20/18639 0.35 1.51642259414226 0.157807111269715 0.44358385478756 GO:0015095 magnesium ion transmembrane transporter activity 7/4302 20/18639 0.35 1.51642259414226 0.157807111269715 0.44358385478756 GO:0016004 phospholipase activator activity 7/4302 20/18639 0.35 1.51642259414226 0.157807111269715 0.44358385478756 GO:0016502 nucleotide receptor activity 7/4302 20/18639 0.35 1.51642259414226 0.157807111269715 0.44358385478756 GO:0061608 nuclear import signal receptor activity 7/4302 20/18639 0.35 1.51642259414226 0.157807111269715 0.44358385478756 GO:0005035 death receptor activity 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0017154 semaphorin receptor activity 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0032396 inhibitory MHC class I receptor activity 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0043560 insulin receptor substrate binding 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0140333 glycerophospholipid flippase activity 5/4302 13/18639 0.384615384615385 1.66639845510138 0.160273647441685 0.444909004724015 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 16/4302 54/18639 0.296296296296296 1.28374399504107 0.162495159265241 0.450141869765822 GO:0010485 histone H4 acetyltransferase activity 11/4302 35/18639 0.314285714285714 1.36168559473999 0.164526307576537 0.454826858548359 GO:0060229 lipase activator activity 8/4302 24/18639 0.333333333333333 1.4442119944212 0.169362642593477 0.467231372763036 GO:0035064 methylated histone binding 21/4302 74/18639 0.283783783783784 1.22953183308832 0.17136655581909 0.470818175946492 GO:0048029 monosaccharide binding 21/4302 74/18639 0.283783783783784 1.22953183308832 0.17136655581909 0.470818175946492 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 35/4302 130/18639 0.269230769230769 1.16647891857097 0.173223903805433 0.474945867400961 GO:0008200 ion channel inhibitor activity 13/4302 43/18639 0.302325581395349 1.30986669261458 0.174028235788687 0.475977749386459 GO:0001784 phosphotyrosine residue binding 14/4302 47/18639 0.297872340425532 1.2905724205466 0.17750541161618 0.475977749386459 GO:0061749 forked DNA-dependent helicase activity 14/4302 47/18639 0.297872340425532 1.2905724205466 0.17750541161618 0.475977749386459 GO:0046625 sphingolipid binding 9/4302 28/18639 0.321428571428571 1.39263299462044 0.17814870281669 0.475977749386459 GO:0051119 sugar transmembrane transporter activity 9/4302 28/18639 0.321428571428571 1.39263299462044 0.17814870281669 0.475977749386459 GO:0046965 nuclear retinoid X receptor binding 6/4302 17/18639 0.352941176470588 1.52916564115186 0.179064230601835 0.475977749386459 GO:1901567 fatty acid derivative binding 6/4302 17/18639 0.352941176470588 1.52916564115186 0.179064230601835 0.475977749386459 GO:0003743 translation initiation factor activity 15/4302 51/18639 0.294117647058824 1.27430470095988 0.180345509316937 0.475977749386459 GO:0004382 GDP phosphatase activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0004955 prostaglandin receptor activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0005345 purine nucleobase transmembrane transporter activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0005522 profilin binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0008140 cAMP response element binding protein binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0031996 thioesterase binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0032052 bile acid binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0043422 protein kinase B binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0045322 unmethylated CpG binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0098505 G-rich strand telomeric DNA binding 4/4302 10/18639 0.4 1.73305439330544 0.181070758174669 0.475977749386459 GO:0140142 nucleocytoplasmic carrier activity 10/4302 32/18639 0.3125 1.35394874476987 0.184943415619145 0.485204490389051 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 59/4302 229/18639 0.25764192139738 1.11626865944346 0.185703399908839 0.486244910133124 GO:0001216 DNA-binding transcription activator activity 122/4302 491/18639 0.24847250509165 1.07654091641173 0.186927604589922 0.487599131934702 GO:0042826 histone deacetylase binding 34/4302 127/18639 0.267716535433071 1.15991829473199 0.186949442961511 0.487599131934702 GO:0001540 amyloid-beta binding 23/4302 83/18639 0.27710843373494 1.20060997126582 0.189790927927051 0.492481354871174 GO:0016409 palmitoyltransferase activity 11/4302 36/18639 0.305555555555556 1.3238609948861 0.190258722616547 0.492481354871174 GO:0055106 ubiquitin-protein transferase regulator activity 11/4302 36/18639 0.305555555555556 1.3238609948861 0.190258722616547 0.492481354871174 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0001846 opsonin binding 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0010314 phosphatidylinositol-5-phosphate binding 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0035613 RNA stem-loop binding 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0140312 cargo adaptor activity 7/4302 21/18639 0.333333333333333 1.4442119944212 0.192133981496826 0.492481354871174 GO:0001223 transcription coactivator binding 13/4302 44/18639 0.295454545454545 1.28009699505515 0.197752729954533 0.50591424986456 GO:0009378 four-way junction helicase activity 14/4302 48/18639 0.291666666666667 1.26368549511855 0.200361752000256 0.510636236526366 GO:0036121 double-stranded DNA helicase activity 14/4302 48/18639 0.291666666666667 1.26368549511855 0.200361752000256 0.510636236526366 GO:0019706 protein-cysteine S-palmitoyltransferase activity 8/4302 25/18639 0.32 1.38644351464435 0.201561398888962 0.510774908548165 GO:0019707 protein-cysteine S-acyltransferase activity 8/4302 25/18639 0.32 1.38644351464435 0.201561398888962 0.510774908548165 GO:0042974 nuclear retinoic acid receptor binding 8/4302 25/18639 0.32 1.38644351464435 0.201561398888962 0.510774908548165 GO:0005347 ATP transmembrane transporter activity 5/4302 14/18639 0.357142857142857 1.54736999402271 0.204419140352455 0.514695050000687 GO:0008559 ABC-type xenobiotic transporter activity 5/4302 14/18639 0.357142857142857 1.54736999402271 0.204419140352455 0.514695050000687 GO:0015386 potassium:proton antiporter activity 5/4302 14/18639 0.357142857142857 1.54736999402271 0.204419140352455 0.514695050000687 GO:0005496 steroid binding 29/4302 108/18639 0.268518518518519 1.16339299550597 0.204647060239436 0.514695050000687 GO:0043178 alcohol binding 25/4302 92/18639 0.271739130434783 1.1773467345825 0.20674898730245 0.519005900582886 GO:0051117 ATPase binding 23/4302 84/18639 0.273809523809524 1.18631699541741 0.207287694580666 0.519383774061669 GO:0016417 S-acyltransferase activity 9/4302 29/18639 0.310344827586207 1.34461116721974 0.208523222967885 0.519560656109926 GO:0035250 UDP-galactosyltransferase activity 9/4302 29/18639 0.310344827586207 1.34461116721974 0.208523222967885 0.519560656109926 GO:0051861 glycolipid binding 9/4302 29/18639 0.310344827586207 1.34461116721974 0.208523222967885 0.519560656109926 GO:0000400 four-way junction DNA binding 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:0008308 voltage-gated monoatomic anion channel activity 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:0017128 phospholipid scramblase activity 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:0030228 lipoprotein particle receptor activity 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:0035615 clathrin adaptor activity 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:1990381 ubiquitin-specific protease binding 6/4302 18/18639 0.333333333333333 1.4442119944212 0.219198610555086 0.540124753080487 GO:0001530 lipopolysaccharide binding 12/4302 41/18639 0.292682926829268 1.26808858046739 0.220633616092942 0.541665648316251 GO:0140318 protein transporter activity 12/4302 41/18639 0.292682926829268 1.26808858046739 0.220633616092942 0.541665648316251 GO:0008009 chemokine activity 13/4302 45/18639 0.288888888888889 1.25165039516504 0.222849723426585 0.54434794228776 GO:0051539 4 iron, 4 sulfur cluster binding 13/4302 45/18639 0.288888888888889 1.25165039516504 0.222849723426585 0.54434794228776 GO:0016251 RNA polymerase II general transcription initiation factor activity 15/4302 53/18639 0.283018867924528 1.22621773111234 0.225635799507514 0.54434794228776 GO:0015101 organic cation transmembrane transporter activity 22/4302 81/18639 0.271604938271605 1.17676532878764 0.226100103680244 0.54434794228776 GO:0070279 vitamin B6 binding 16/4302 57/18639 0.280701754385965 1.21617852161785 0.226413591254274 0.54434794228776 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/4302 61/18639 0.278688524590164 1.20745592976199 0.226880136788422 0.54434794228776 GO:0004521 RNA endonuclease activity 20/4302 73/18639 0.273972602739726 1.18702355705852 0.226900412284882 0.54434794228776 GO:0019843 rRNA binding 18/4302 65/18639 0.276923076923077 1.199806887673 0.227089542561927 0.54434794228776 GO:0004407 histone deacetylase activity 7/4302 22/18639 0.318181818181818 1.37856599467478 0.229105152791706 0.54434794228776 GO:0033558 protein lysine deacetylase activity 7/4302 22/18639 0.318181818181818 1.37856599467478 0.229105152791706 0.54434794228776 GO:0034062 5'-3' RNA polymerase activity 7/4302 22/18639 0.318181818181818 1.37856599467478 0.229105152791706 0.54434794228776 GO:0061133 endopeptidase activator activity 7/4302 22/18639 0.318181818181818 1.37856599467478 0.229105152791706 0.54434794228776 GO:0097747 RNA polymerase activity 7/4302 22/18639 0.318181818181818 1.37856599467478 0.229105152791706 0.54434794228776 GO:0016798 hydrolase activity, acting on glycosyl bonds 34/4302 130/18639 0.261538461538462 1.13315094946894 0.230058791370995 0.54434794228776 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0004954 prostanoid receptor activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0015205 nucleobase transmembrane transporter activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0015217 ADP transmembrane transporter activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0034713 type I transforming growth factor beta receptor binding 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0047676 arachidonate-CoA ligase activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0048185 activin binding 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0050786 RAGE receptor binding 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0070990 snRNP binding 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0180030 inositol phosphate kinase activity 4/4302 11/18639 0.363636363636364 1.57550399391404 0.235328514751571 0.54434794228776 GO:0005160 transforming growth factor beta receptor binding 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0005227 calcium-activated cation channel activity 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0008157 protein phosphatase 1 binding 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0015145 monosaccharide transmembrane transporter activity 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0051139 metal cation:proton antiporter activity 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0097602 cullin family protein binding 8/4302 26/18639 0.307692307692308 1.33311876408111 0.23596547573012 0.54434794228776 GO:0031210 phosphatidylcholine binding 9/4302 30/18639 0.3 1.29979079497908 0.24079283772988 0.55167948096332 GO:0043995 histone H4K5 acetyltransferase activity 9/4302 30/18639 0.3 1.29979079497908 0.24079283772988 0.55167948096332 GO:0043996 histone H4K8 acetyltransferase activity 9/4302 30/18639 0.3 1.29979079497908 0.24079283772988 0.55167948096332 GO:0043997 histone H4K12 acetyltransferase activity 9/4302 30/18639 0.3 1.29979079497908 0.24079283772988 0.55167948096332 GO:0004402 histone acetyltransferase activity 12/4302 42/18639 0.285714285714286 1.23789599521817 0.248168212471888 0.565671325872889 GO:0004520 DNA endonuclease activity 12/4302 42/18639 0.285714285714286 1.23789599521817 0.248168212471888 0.565671325872889 GO:0019894 kinesin binding 12/4302 42/18639 0.285714285714286 1.23789599521817 0.248168212471888 0.565671325872889 GO:0140375 immune receptor activity 40/4302 156/18639 0.256410256410256 1.11093230340092 0.249522118338775 0.566601429766687 GO:0017116 single-stranded DNA helicase activity 16/4302 58/18639 0.275862068965517 1.19520992641754 0.249820752984677 0.566601429766687 GO:0050661 NADP binding 15/4302 54/18639 0.277777777777778 1.203509995351 0.249920661139157 0.566601429766687 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/4302 15/18639 0.333333333333333 1.4442119944212 0.251964013984439 0.566601429766687 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/4302 15/18639 0.333333333333333 1.4442119944212 0.251964013984439 0.566601429766687 GO:0004953 icosanoid receptor activity 5/4302 15/18639 0.333333333333333 1.4442119944212 0.251964013984439 0.566601429766687 GO:0141050 histone H3K deacetylase activity 5/4302 15/18639 0.333333333333333 1.4442119944212 0.251964013984439 0.566601429766687 GO:0141051 histone H4K deacetylase activity 5/4302 15/18639 0.333333333333333 1.4442119944212 0.251964013984439 0.566601429766687 GO:0004713 protein tyrosine kinase activity 36/4302 140/18639 0.257142857142857 1.11410639569635 0.257195751710162 0.57739583185939 GO:0044325 transmembrane transporter binding 35/4302 136/18639 0.257352941176471 1.1150166133399 0.259163477196021 0.580838747886561 GO:0022821 solute:potassium antiporter activity 6/4302 19/18639 0.315789473684211 1.36820083682008 0.261948730853282 0.585120871254911 GO:0046527 glucosyltransferase activity 6/4302 19/18639 0.315789473684211 1.36820083682008 0.261948730853282 0.585120871254911 GO:0030165 PDZ domain binding 22/4302 83/18639 0.265060240963855 1.14840953773252 0.265648405035575 0.592395943229332 GO:0042171 lysophosphatidic acid acyltransferase activity 7/4302 23/18639 0.304347826086957 1.3186283427324 0.268212637000615 0.593171088110451 GO:0044013 histone H2B acetyltransferase activity 7/4302 23/18639 0.304347826086957 1.3186283427324 0.268212637000615 0.593171088110451 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 7/4302 23/18639 0.304347826086957 1.3186283427324 0.268212637000615 0.593171088110451 GO:0070577 lysine-acetylated histone binding 7/4302 23/18639 0.304347826086957 1.3186283427324 0.268212637000615 0.593171088110451 GO:0071617 lysophospholipid acyltransferase activity 7/4302 23/18639 0.304347826086957 1.3186283427324 0.268212637000615 0.593171088110451 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 18/4302 67/18639 0.26865671641791 1.16399175669768 0.271626716414813 0.598982990583721 GO:0005044 scavenger receptor activity 8/4302 27/18639 0.296296296296296 1.28374399504107 0.272183601102319 0.598982990583721 GO:0008320 protein transmembrane transporter activity 8/4302 27/18639 0.296296296296296 1.28374399504107 0.272183601102319 0.598982990583721 GO:0005504 fatty acid binding 13/4302 47/18639 0.276595744680851 1.19838867622185 0.27658330399686 0.606020651796063 GO:0061733 protein-lysine-acetyltransferase activity 13/4302 47/18639 0.276595744680851 1.19838867622185 0.27658330399686 0.606020651796063 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 11/4302 39/18639 0.282051282051282 1.22202553374101 0.276740372382208 0.606020651796063 GO:0004859 phospholipase inhibitor activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0005025 transforming growth factor beta receptor activity, type I 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0005026 transforming growth factor beta receptor activity, type II 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0015269 calcium-activated potassium channel activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016273 arginine N-methyltransferase activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016274 protein-arginine N-methyltransferase activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016361 activin receptor activity, type I 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016362 activin receptor activity, type II 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016840 carbon-nitrogen lyase activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0017002 activin receptor activity 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0034452 dynactin binding 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0035497 cAMP response element binding 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0070410 co-SMAD binding 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0141221 histone deacetylase activity, hydrolytic mechanism 4/4302 12/18639 0.333333333333333 1.4442119944212 0.292719607254906 0.625653090266877 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 16/4302 60/18639 0.266666666666667 1.15536959553696 0.299167619292654 0.637004504526574 GO:0098531 ligand-modulated transcription factor activity 16/4302 60/18639 0.266666666666667 1.15536959553696 0.299167619292654 0.637004504526574 GO:0030170 pyridoxal phosphate binding 15/4302 56/18639 0.267857142857143 1.16052749551704 0.301172363918766 0.637004504526574 GO:0005149 interleukin-1 receptor binding 5/4302 16/18639 0.3125 1.35394874476987 0.301839204685985 0.637004504526574 GO:0008142 oxysterol binding 5/4302 16/18639 0.3125 1.35394874476987 0.301839204685985 0.637004504526574 GO:0015385 sodium:proton antiporter activity 5/4302 16/18639 0.3125 1.35394874476987 0.301839204685985 0.637004504526574 GO:0034450 ubiquitin-ubiquitin ligase activity 5/4302 16/18639 0.3125 1.35394874476987 0.301839204685985 0.637004504526574 GO:0097027 ubiquitin-protein transferase activator activity 5/4302 16/18639 0.3125 1.35394874476987 0.301839204685985 0.637004504526574 GO:0030159 signaling receptor complex adaptor activity 14/4302 52/18639 0.269230769230769 1.16647891857097 0.303091881830905 0.638640847070473 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/4302 20/18639 0.3 1.29979079497908 0.306580853531955 0.638688961228615 GO:0140939 histone H4 methyltransferase activity 6/4302 20/18639 0.3 1.29979079497908 0.306580853531955 0.638688961228615 GO:0004177 aminopeptidase activity 11/4302 40/18639 0.275 1.19147489539749 0.307955649751983 0.638688961228615 GO:0015144 carbohydrate transmembrane transporter activity 11/4302 40/18639 0.275 1.19147489539749 0.307955649751983 0.638688961228615 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0015149 hexose transmembrane transporter activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0015295 solute:proton symporter activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0043998 histone H2A acetyltransferase activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0055056 D-glucose transmembrane transporter activity 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0140033 acetylation-dependent protein binding 7/4302 24/18639 0.291666666666667 1.26368549511855 0.308915575874142 0.638688961228615 GO:0030515 snoRNA binding 9/4302 32/18639 0.28125 1.21855387029289 0.309746118247065 0.638688961228615 GO:0042910 xenobiotic transmembrane transporter activity 9/4302 32/18639 0.28125 1.21855387029289 0.309746118247065 0.638688961228615 GO:0050698 proteoglycan sulfotransferase activity 8/4302 28/18639 0.285714285714286 1.23789599521817 0.30979756041657 0.638688961228615 GO:0015297 antiporter activity 34/4302 135/18639 0.251851851851852 1.09118239578491 0.31076181863467 0.639691251281827 GO:0160215 deacylase activity 17/4302 65/18639 0.261538461538462 1.13315094946894 0.321897458582888 0.661595698285568 GO:0035401 histone H3Y41 kinase activity 29/4302 115/18639 0.252173913043478 1.09257776969256 0.326270717988501 0.668530200105075 GO:0140801 histone H2AXY142 kinase activity 29/4302 115/18639 0.252173913043478 1.09257776969256 0.326270717988501 0.668530200105075 GO:0002020 protease binding 34/4302 136/18639 0.25 1.0831589958159 0.327961265780886 0.670966626322362 GO:0034212 protein N-acetyltransferase activity 14/4302 53/18639 0.264150943396226 1.14446988237152 0.330896629331609 0.675938458085027 GO:0004857 enzyme inhibitor activity 100/4302 416/18639 0.240384615384615 1.04149903443837 0.33783198543218 0.689053653213806 GO:0015175 neutral L-amino acid transmembrane transporter activity 11/4302 41/18639 0.268292682926829 1.16241453209511 0.339973728760297 0.690508631464564 GO:0140828 metal cation:monoatomic cation antiporter activity 11/4302 41/18639 0.268292682926829 1.16241453209511 0.339973728760297 0.690508631464564 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 23/4302 91/18639 0.252747252747253 1.09506184192377 0.347503908150627 0.690508631464564 GO:0099604 ligand-gated calcium channel activity 8/4302 29/18639 0.275862068965517 1.19520992641754 0.348378260397022 0.690508631464564 GO:0000030 mannosyltransferase activity 7/4302 25/18639 0.28 1.21313807531381 0.350664422479489 0.690508631464564 GO:0005537 D-mannose binding 7/4302 25/18639 0.28 1.21313807531381 0.350664422479489 0.690508631464564 GO:0015662 P-type ion transporter activity 7/4302 25/18639 0.28 1.21313807531381 0.350664422479489 0.690508631464564 GO:0047617 fatty acyl-CoA hydrolase activity 7/4302 25/18639 0.28 1.21313807531381 0.350664422479489 0.690508631464564 GO:0140358 P-type transmembrane transporter activity 7/4302 25/18639 0.28 1.21313807531381 0.350664422479489 0.690508631464564 GO:0015179 L-amino acid transmembrane transporter activity 16/4302 62/18639 0.258064516129032 1.11809960858415 0.351090072808264 0.690508631464564 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0019855 calcium channel inhibitor activity 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0030955 potassium ion binding 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0061459 L-arginine transmembrane transporter activity 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0070123 transforming growth factor beta receptor activity, type III 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0097157 pre-mRNA intronic binding 4/4302 13/18639 0.307692307692308 1.33311876408111 0.351584478283004 0.690508631464564 GO:0019200 carbohydrate kinase activity 6/4302 21/18639 0.285714285714286 1.23789599521817 0.352359602346006 0.690508631464564 GO:0070182 DNA polymerase binding 6/4302 21/18639 0.285714285714286 1.23789599521817 0.352359602346006 0.690508631464564 GO:1904047 S-adenosyl-L-methionine binding 6/4302 21/18639 0.285714285714286 1.23789599521817 0.352359602346006 0.690508631464564 GO:0004549 tRNA-specific ribonuclease activity 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0016805 dipeptidase activity 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0017110 nucleoside diphosphate phosphatase activity 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0032183 SUMO binding 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0048038 quinone binding 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0070402 NADPH binding 5/4302 17/18639 0.294117647058824 1.27430470095988 0.352995443887714 0.690508631464564 GO:0051287 NAD binding 14/4302 54/18639 0.259259259259259 1.12327599566093 0.359238218198967 0.700268227315792 GO:0016835 carbon-oxygen lyase activity 20/4302 79/18639 0.253164556962025 1.09686986918066 0.359554762455866 0.700268227315792 GO:0033293 monocarboxylic acid binding 20/4302 79/18639 0.253164556962025 1.09686986918066 0.359554762455866 0.700268227315792 GO:0016651 oxidoreductase activity, acting on NAD(P)H 22/4302 88/18639 0.25 1.0831589958159 0.373799467020474 0.726953033246213 GO:0004879 nuclear receptor activity 15/4302 59/18639 0.254237288135593 1.10151762286363 0.382708814375222 0.743199410209067 GO:0001968 fibronectin binding 8/4302 30/18639 0.266666666666667 1.15536959553696 0.387500232275983 0.743470156302515 GO:0022839 monoatomic ion-gated channel activity 8/4302 30/18639 0.266666666666667 1.15536959553696 0.387500232275983 0.743470156302515 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/4302 26/18639 0.269230769230769 1.16647891857097 0.392921929176625 0.743470156302515 GO:0016289 acyl-CoA hydrolase activity 7/4302 26/18639 0.269230769230769 1.16647891857097 0.392921929176625 0.743470156302515 GO:0019865 immunoglobulin binding 7/4302 26/18639 0.269230769230769 1.16647891857097 0.392921929176625 0.743470156302515 GO:0034237 protein kinase A regulatory subunit binding 7/4302 26/18639 0.269230769230769 1.16647891857097 0.392921929176625 0.743470156302515 GO:0050750 low-density lipoprotein particle receptor binding 7/4302 26/18639 0.269230769230769 1.16647891857097 0.392921929176625 0.743470156302515 GO:0005518 collagen binding 18/4302 72/18639 0.25 1.0831589958159 0.39342789481175 0.743470156302515 GO:0005048 signal sequence binding 13/4302 51/18639 0.254901960784314 1.10439740749856 0.393463794012461 0.743470156302515 GO:0032931 histone H3K56 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0043992 histone H3K9 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0043993 histone H3K18 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0043994 histone H3K23 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0043999 histone H2AK5 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044012 histone H2AK9 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044014 histone H2BK5 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044015 histone H2BK12 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044016 histone H3K4 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044017 histone H3K27 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0044018 histone H3K36 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0046972 histone H4K16 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0140908 histone H3K122 acetyltransferase activity 6/4302 22/18639 0.272727272727273 1.18162799543553 0.398580020928869 0.743470156302515 GO:0031406 carboxylic acid binding 45/4302 187/18639 0.240641711229947 1.04261293714899 0.402063902622297 0.743470156302515 GO:0003746 translation elongation factor activity 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:0016854 racemase and epimerase activity 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:0017075 syntaxin-1 binding 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:0032393 MHC class I receptor activity 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:0034185 apolipoprotein binding 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:1901611 phosphatidylglycerol binding 5/4302 18/18639 0.277777777777778 1.203509995351 0.404455764400264 0.743470156302515 GO:0005161 platelet-derived growth factor receptor binding 4/4302 14/18639 0.285714285714286 1.23789599521817 0.410450613455225 0.743470156302515 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 4/4302 14/18639 0.285714285714286 1.23789599521817 0.410450613455225 0.743470156302515 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 4/4302 14/18639 0.285714285714286 1.23789599521817 0.410450613455225 0.743470156302515 GO:0098821 BMP receptor activity 4/4302 14/18639 0.285714285714286 1.23789599521817 0.410450613455225 0.743470156302515 GO:1901474 azole transmembrane transporter activity 4/4302 14/18639 0.285714285714286 1.23789599521817 0.410450613455225 0.743470156302515 GO:0000217 DNA secondary structure binding 10/4302 39/18639 0.256410256410256 1.11093230340092 0.412016271514969 0.743470156302515 GO:0016410 N-acyltransferase activity 23/4302 94/18639 0.24468085106383 1.06011305973471 0.413636957244482 0.743470156302515 GO:0000182 rDNA binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0005031 tumor necrosis factor receptor activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0005528 FK506 binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0008190 eukaryotic initiation factor 4E binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0015203 polyamine transmembrane transporter activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0016868 intramolecular phosphotransferase activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0030957 Tat protein binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0031434 mitogen-activated protein kinase kinase binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0032356 oxidized DNA binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0033204 ribonuclease P RNA binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0042975 peroxisome proliferator activated receptor binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0050308 sugar-phosphatase activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0050815 phosphoserine residue binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0051880 G-quadruplex DNA binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0071723 lipopeptide binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0140999 histone H3K4 trimethyltransferase activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:1990757 ubiquitin ligase activator activity 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:1990763 arrestin family protein binding 3/4302 10/18639 0.3 1.29979079497908 0.416187703341244 0.743470156302515 GO:0005080 protein kinase C binding 13/4302 52/18639 0.25 1.0831589958159 0.423587764739647 0.755680572295529 GO:0070325 lipoprotein particle receptor binding 8/4302 31/18639 0.258064516129032 1.11809960858415 0.42675410154312 0.760315563068835 GO:0043177 organic acid binding 45/4302 189/18639 0.238095238095238 1.03157999601514 0.433633915000216 0.771545449827512 GO:0004683 calcium/calmodulin-dependent protein kinase activity 7/4302 27/18639 0.259259259259259 1.12327599566093 0.435180344002633 0.773268659064439 GO:0016790 thiolester hydrolase activity 11/4302 44/18639 0.25 1.0831589958159 0.438409030614885 0.775044861602993 GO:0019205 nucleobase-containing compound kinase activity 11/4302 44/18639 0.25 1.0831589958159 0.438409030614885 0.775044861602993 GO:0016836 hydro-lyase activity 15/4302 61/18639 0.245901639344262 1.06540229096646 0.438496980742501 0.775044861602993 GO:0019905 syntaxin binding 15/4302 61/18639 0.245901639344262 1.06540229096646 0.438496980742501 0.775044861602993 GO:0031491 nucleosome binding 18/4302 74/18639 0.243243243243243 1.05388442836142 0.444139580067558 0.783747230428897 GO:0140103 catalytic activity, acting on a glycoprotein 6/4302 23/18639 0.260869565217391 1.1302528651992 0.444592038785899 0.783747230428897 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 10/4302 40/18639 0.25 1.0831589958159 0.446703145435964 0.785399222855874 GO:0050997 quaternary ammonium group binding 10/4302 40/18639 0.25 1.0831589958159 0.446703145435964 0.785399222855874 GO:1990782 protein tyrosine kinase binding 28/4302 117/18639 0.239316239316239 1.03687014984086 0.448934120946318 0.788285897409677 GO:0008028 monocarboxylic acid transmembrane transporter activity 17/4302 70/18639 0.242857142857143 1.05221159593545 0.451150434236276 0.790220255065318 GO:0005544 calcium-dependent phospholipid binding 13/4302 53/18639 0.245283018867925 1.06272203363069 0.453712383747259 0.790220255065318 GO:0051018 protein kinase A binding 13/4302 53/18639 0.245283018867925 1.06272203363069 0.453712383747259 0.790220255065318 GO:0008301 DNA binding, bending 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0015245 fatty acid transmembrane transporter activity 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0031420 alkali metal ion binding 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0042800 histone H3K4 methyltransferase activity 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0042834 peptidoglycan binding 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0050145 nucleoside monophosphate kinase activity 5/4302 19/18639 0.263157894736842 1.14016736401674 0.455351133524186 0.790220255065318 GO:0071813 lipoprotein particle binding 8/4302 32/18639 0.25 1.0831589958159 0.465756762641805 0.805004955503815 GO:0071814 protein-lipid complex binding 8/4302 32/18639 0.25 1.0831589958159 0.465756762641805 0.805004955503815 GO:0004467 long-chain fatty acid-CoA ligase activity 4/4302 15/18639 0.266666666666667 1.15536959553696 0.468082104171874 0.805004955503815 GO:0008252 nucleotidase activity 4/4302 15/18639 0.266666666666667 1.15536959553696 0.468082104171874 0.805004955503815 GO:0015929 hexosaminidase activity 4/4302 15/18639 0.266666666666667 1.15536959553696 0.468082104171874 0.805004955503815 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/4302 15/18639 0.266666666666667 1.15536959553696 0.468082104171874 0.805004955503815 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/4302 15/18639 0.266666666666667 1.15536959553696 0.468082104171874 0.805004955503815 GO:0016866 intramolecular transferase activity 7/4302 28/18639 0.25 1.0831589958159 0.476974605197987 0.812553632302952 GO:0036408 histone H3K14 acetyltransferase activity 7/4302 28/18639 0.25 1.0831589958159 0.476974605197987 0.812553632302952 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/4302 41/18639 0.24390243902439 1.05674048372283 0.481131989524888 0.812553632302952 GO:0017080 sodium channel regulator activity 10/4302 41/18639 0.24390243902439 1.05674048372283 0.481131989524888 0.812553632302952 GO:0017069 snRNA binding 13/4302 54/18639 0.240740740740741 1.04304199597087 0.483667606969888 0.812553632302952 GO:0000099 sulfur amino acid transmembrane transporter activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0001851 complement component C3b binding 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0003953 NAD+ nucleosidase activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0005114 type II transforming growth factor beta receptor binding 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0008432 JUN kinase binding 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0019203 carbohydrate phosphatase activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0019206 nucleoside kinase activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0032794 GTPase activating protein binding 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/4302 11/18639 0.272727272727273 1.18162799543553 0.484009899062371 0.812553632302952 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/4302 24/18639 0.25 1.0831589958159 0.489817526423152 0.81819706660946 GO:0005315 phosphate transmembrane transporter activity 6/4302 24/18639 0.25 1.0831589958159 0.489817526423152 0.81819706660946 GO:0050431 transforming growth factor beta binding 6/4302 24/18639 0.25 1.0831589958159 0.489817526423152 0.81819706660946 GO:0070300 phosphatidic acid binding 6/4302 24/18639 0.25 1.0831589958159 0.489817526423152 0.81819706660946 GO:0019213 deacetylase activity 9/4302 37/18639 0.243243243243243 1.05388442836142 0.492025445134646 0.81983816387317 GO:0070001 aspartic-type peptidase activity 9/4302 37/18639 0.243243243243243 1.05388442836142 0.492025445134646 0.81983816387317 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/4302 33/18639 0.242424242424242 1.05033599594269 0.504159176412484 0.839011166716298 GO:0005516 calmodulin binding 48/4302 207/18639 0.231884057971014 1.0046692135104 0.512500184417285 0.851832604658791 GO:0010484 histone H3 acetyltransferase activity 7/4302 29/18639 0.241379310344828 1.04580868561535 0.517891623998293 0.859725797654735 GO:0003688 DNA replication origin binding 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0004708 MAP kinase kinase activity 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0005024 transforming growth factor beta receptor activity 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0005159 insulin-like growth factor receptor binding 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0030275 LRR domain binding 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0055102 lipase inhibitor activity 4/4302 16/18639 0.25 1.0831589958159 0.523496404000503 0.861547587395663 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 20/4302 86/18639 0.232558139534884 1.00758976354967 0.526583589130392 0.864501646940447 GO:0016209 antioxidant activity 20/4302 86/18639 0.232558139534884 1.00758976354967 0.526583589130392 0.864501646940447 GO:0042162 telomeric DNA binding 9/4302 38/18639 0.236842105263158 1.02615062761506 0.527620538735401 0.865142501014665 GO:0001848 complement binding 6/4302 25/18639 0.24 1.03983263598326 0.533760611879045 0.873070536300931 GO:0008483 transaminase activity 6/4302 25/18639 0.24 1.03983263598326 0.533760611879045 0.873070536300931 GO:0043495 protein-membrane adaptor activity 11/4302 47/18639 0.234042553191489 1.01402118757233 0.535590420802225 0.873336583285139 GO:0015291 secondary active transmembrane transporter activity 66/4302 287/18639 0.229965156794425 0.996355313224381 0.536833971383688 0.873336583285139 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 8/4302 34/18639 0.235294117647059 1.01944376076791 0.54165185126145 0.873336583285139 GO:0003995 acyl-CoA dehydrogenase activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0004300 enoyl-CoA hydratase activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0004526 ribonuclease P activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0005049 nuclear export signal receptor activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0005247 voltage-gated chloride channel activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0005527 macrolide binding 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0008603 cAMP-dependent protein kinase regulator activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0015166 polyol transmembrane transporter activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0015368 calcium:monoatomic cation antiporter activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0016208 AMP binding 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0016801 hydrolase activity, acting on ether bonds 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0016803 ether hydrolase activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0017166 vinculin binding 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0042301 phosphate ion binding 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0097371 MDM2/MDM4 family protein binding 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/4302 12/18639 0.25 1.0831589958159 0.547773329664859 0.873336583285139 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 10/4302 43/18639 0.232558139534884 1.00758976354967 0.548283056770939 0.873336583285139 GO:0015174 basic amino acid transmembrane transporter activity 5/4302 21/18639 0.238095238095238 1.03157999601514 0.552622984513968 0.878158614346425 GO:0072542 protein phosphatase activator activity 5/4302 21/18639 0.238095238095238 1.03157999601514 0.552622984513968 0.878158614346425 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/4302 30/18639 0.233333333333333 1.01094839609484 0.557575960609432 0.882883592065585 GO:0016769 transferase activity, transferring nitrogenous groups 7/4302 30/18639 0.233333333333333 1.01094839609484 0.557575960609432 0.882883592065585 GO:0051721 protein phosphatase 2A binding 7/4302 30/18639 0.233333333333333 1.01094839609484 0.557575960609432 0.882883592065585 GO:0016758 hexosyltransferase activity 45/4302 197/18639 0.228426395939086 0.989688422572903 0.5596255100275 0.885081480398103 GO:0097110 scaffold protein binding 16/4302 70/18639 0.228571428571429 0.990316796174537 0.564173891858882 0.891221567068695 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0005092 GDP-dissociation inhibitor activity 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0008429 phosphatidylethanolamine binding 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0019198 transmembrane receptor protein phosphatase activity 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0030169 low-density lipoprotein particle binding 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 4/4302 17/18639 0.235294117647059 1.01944376076791 0.575958237881362 0.901408591732062 GO:0005112 Notch binding 6/4302 26/18639 0.230769230769231 0.99983907306083 0.576012216689771 0.901408591732062 GO:0030507 spectrin binding 6/4302 26/18639 0.230769230769231 0.99983907306083 0.576012216689771 0.901408591732062 GO:0005246 calcium channel regulator activity 12/4302 53/18639 0.226415094339623 0.980974184889871 0.583490420767255 0.910133146152517 GO:0008146 sulfotransferase activity 12/4302 53/18639 0.226415094339623 0.980974184889871 0.583490420767255 0.910133146152517 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 41/4302 181/18639 0.226519337016575 0.981425830463025 0.583627981613497 0.910133146152517 GO:1902936 phosphatidylinositol bisphosphate binding 25/4302 111/18639 0.225225225225225 0.975818915149459 0.59243007665272 0.922783984355459 GO:0008327 methyl-CpG binding 7/4302 31/18639 0.225806451612903 0.978337157511135 0.595732336170439 0.92469822018103 GO:0016411 acylglycerol O-acyltransferase activity 7/4302 31/18639 0.225806451612903 0.978337157511135 0.595732336170439 0.92469822018103 GO:0016878 acid-thiol ligase activity 7/4302 31/18639 0.225806451612903 0.978337157511135 0.595732336170439 0.92469822018103 GO:0008970 phospholipase A1 activity 5/4302 22/18639 0.227272727272727 0.984689996196272 0.597929738509585 0.925960636719705 GO:0016881 acid-amino acid ligase activity 5/4302 22/18639 0.227272727272727 0.984689996196272 0.597929738509585 0.925960636719705 GO:0002161 aminoacyl-tRNA editing activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0005542 folic acid binding 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0008035 high-density lipoprotein particle binding 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0008253 5'-nucleotidase activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0009982 pseudouridine synthase activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0071714 icosanoid transmembrane transporter activity 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0089720 caspase binding 3/4302 13/18639 0.230769230769231 0.99983907306083 0.606629985079415 0.92868526319938 GO:0042277 peptide binding 56/4302 249/18639 0.224899598393574 0.974408092621532 0.612636913947039 0.934855282284933 GO:0004190 aspartic-type endopeptidase activity 8/4302 36/18639 0.222222222222222 0.9628079962808 0.612885841184926 0.934855282284933 GO:0045505 dynein intermediate chain binding 8/4302 36/18639 0.222222222222222 0.9628079962808 0.612885841184926 0.934855282284933 GO:0042379 chemokine receptor binding 16/4302 72/18639 0.222222222222222 0.9628079962808 0.614127647038433 0.934855282284933 GO:0030971 receptor tyrosine kinase binding 18/4302 81/18639 0.222222222222222 0.9628079962808 0.615657971057056 0.934855282284933 GO:0016405 CoA-ligase activity 6/4302 27/18639 0.222222222222222 0.9628079962808 0.616249894600382 0.934855282284933 GO:0023026 MHC class II protein complex binding 6/4302 27/18639 0.222222222222222 0.9628079962808 0.616249894600382 0.934855282284933 GO:0035255 ionotropic glutamate receptor binding 6/4302 27/18639 0.222222222222222 0.9628079962808 0.616249894600382 0.934855282284933 GO:0008017 microtubule binding 62/4302 276/18639 0.22463768115942 0.9732733005882 0.620037811767587 0.93953634444511 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/4302 18/18639 0.222222222222222 0.9628079962808 0.624958944590247 0.941141023967159 GO:0015172 acidic amino acid transmembrane transporter activity 4/4302 18/18639 0.222222222222222 0.9628079962808 0.624958944590247 0.941141023967159 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/4302 18/18639 0.222222222222222 0.9628079962808 0.624958944590247 0.941141023967159 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/4302 18/18639 0.222222222222222 0.9628079962808 0.624958944590247 0.941141023967159 GO:0098641 cadherin binding involved in cell-cell adhesion 4/4302 18/18639 0.222222222222222 0.9628079962808 0.624958944590247 0.941141023967159 GO:0015399 primary active transmembrane transporter activity 37/4302 166/18639 0.22289156626506 0.965708020365983 0.625844232251578 0.941141023967159 GO:0048020 CCR chemokine receptor binding 11/4302 50/18639 0.22 0.953179916317992 0.626319893199508 0.941141023967159 GO:0022804 active transmembrane transporter activity 103/4302 457/18639 0.225382932166302 0.976502201917179 0.62786197847292 0.941141023967159 GO:0004812 aminoacyl-tRNA ligase activity 9/4302 41/18639 0.219512195121951 0.951066435350546 0.628130743200802 0.941141023967159 GO:0016875 ligase activity, forming carbon-oxygen bonds 9/4302 41/18639 0.219512195121951 0.951066435350546 0.628130743200802 0.941141023967159 GO:0003774 cytoskeletal motor activity 34/4302 153/18639 0.222222222222222 0.9628079962808 0.630857969502102 0.944169981201133 GO:0031369 translation initiation factor binding 7/4302 32/18639 0.21875 0.947764121338912 0.632125496758456 0.945009960517111 GO:0008374 O-acyltransferase activity 12/4302 55/18639 0.218181818181818 0.945302396348421 0.639560403763522 0.954365814984925 GO:0008171 O-methyltransferase activity 5/4302 23/18639 0.217391304347826 0.941877387666 0.640523543988387 0.954365814984925 GO:0043274 phospholipase binding 5/4302 23/18639 0.217391304347826 0.941877387666 0.640523543988387 0.954365814984925 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 10/4302 46/18639 0.217391304347826 0.941877387666 0.641892176873246 0.955341193166188 GO:0043394 proteoglycan binding 8/4302 37/18639 0.216216216216216 0.936786158543481 0.646226640095349 0.960723604941751 GO:0008081 phosphoric diester hydrolase activity 19/4302 87/18639 0.218390804597701 0.946207858413889 0.649278478320479 0.964189349603552 GO:0046875 ephrin receptor binding 6/4302 28/18639 0.214285714285714 0.928421996413628 0.654234064437399 0.966366035219647 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/4302 28/18639 0.214285714285714 0.928421996413628 0.654234064437399 0.966366035219647 GO:0019842 vitamin binding 33/4302 150/18639 0.22 0.953179916317992 0.654709998081942 0.966366035219647 GO:0016859 cis-trans isomerase activity 9/4302 42/18639 0.214285714285714 0.928421996413628 0.658967155297909 0.966366035219647 GO:0052689 carboxylic ester hydrolase activity 20/4302 92/18639 0.217391304347826 0.941877387666 0.659680003400232 0.966366035219647 GO:0004065 arylsulfatase activity 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0016530 metallochaperone activity 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0034236 protein kinase A catalytic subunit binding 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0042813 Wnt receptor activity 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0071933 Arp2/3 complex binding 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:1901612 cardiolipin binding 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:1990825 sequence-specific mRNA binding 3/4302 14/18639 0.214285714285714 0.928421996413628 0.660133450067831 0.966366035219647 GO:0030296 protein tyrosine kinase activator activity 7/4302 33/18639 0.212121212121212 0.919043996449854 0.666577967620834 0.973627725135854 GO:0051015 actin filament binding 46/4302 209/18639 0.220095693779904 0.95359452263218 0.670159923299146 0.973627725135854 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/4302 19/18639 0.210526315789474 0.912133891213389 0.670187694207864 0.973627725135854 GO:0005229 intracellularly calcium-gated chloride channel activity 4/4302 19/18639 0.210526315789474 0.912133891213389 0.670187694207864 0.973627725135854 GO:0008381 mechanosensitive monoatomic ion channel activity 4/4302 19/18639 0.210526315789474 0.912133891213389 0.670187694207864 0.973627725135854 GO:0034987 immunoglobulin receptor binding 4/4302 19/18639 0.210526315789474 0.912133891213389 0.670187694207864 0.973627725135854 GO:0141147 intracellularly calcium-gated channel activity 4/4302 19/18639 0.210526315789474 0.912133891213389 0.670187694207864 0.973627725135854 GO:0016782 transferase activity, transferring sulphur-containing groups 15/4302 70/18639 0.214285714285714 0.928421996413628 0.673718709059208 0.977695914014338 GO:0015026 coreceptor activity 13/4302 61/18639 0.213114754098361 0.923348652170931 0.676805377538282 0.981111154004573 GO:0004622 lysophospholipase activity 5/4302 24/18639 0.208333333333333 0.90263249651325 0.680183022295028 0.982813049493248 GO:0019957 C-C chemokine binding 5/4302 24/18639 0.208333333333333 0.90263249651325 0.680183022295028 0.982813049493248 GO:0050699 WW domain binding 5/4302 24/18639 0.208333333333333 0.90263249651325 0.680183022295028 0.982813049493248 GO:0008235 metalloexopeptidase activity 14/4302 66/18639 0.212121212121212 0.919043996449854 0.686854115660155 0.9834376690535 GO:0048306 calcium-dependent protein binding 17/4302 80/18639 0.2125 0.920685146443515 0.693035401323336 0.9834376690535 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 7/4302 34/18639 0.205882352941176 0.892013290671917 0.698966220010304 0.9834376690535 GO:0033218 amide binding 54/4302 247/18639 0.218623481781377 0.947215963952366 0.699782712812325 0.9834376690535 GO:0019955 cytokine binding 31/4302 144/18639 0.215277777777778 0.932720246397025 0.702125034593808 0.9834376690535 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/4302 39/18639 0.205128205128205 0.888745842720738 0.707675092472575 0.9834376690535 GO:0004089 carbonate dehydratase activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0010181 FMN binding 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0016846 carbon-sulfur lyase activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0017081 chloride channel regulator activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0031386 protein tag activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0047372 monoacylglycerol lipase activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0140161 monocarboxylate:sodium symporter activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0141047 molecular tag activity 3/4302 15/18639 0.2 0.86652719665272 0.70814628654182 0.9834376690535 GO:0001094 TFIID-class transcription factor complex binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0004935 adrenergic receptor activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0005131 growth hormone receptor binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0008239 dipeptidyl-peptidase activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0015279 store-operated calcium channel activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0016783 sulfurtransferase activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0032395 MHC class II receptor activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0035256 G protein-coupled glutamate receptor binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0042166 acetylcholine binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0043121 neurotrophin binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0043208 glycosphingolipid binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0047429 nucleoside triphosphate diphosphatase activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0070097 delta-catenin binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0070739 protein-glutamic acid ligase activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0070740 tubulin-glutamic acid ligase activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0097177 mitochondrial ribosome binding 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0140135 mechanosensitive monoatomic cation channel activity 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/4302 10/18639 0.2 0.86652719665272 0.710015536850285 0.9834376690535 GO:0016408 C-acyltransferase activity 4/4302 20/18639 0.2 0.86652719665272 0.711499311046097 0.983456692334378 GO:0042288 MHC class I protein binding 4/4302 20/18639 0.2 0.86652719665272 0.711499311046097 0.983456692334378 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 12/4302 58/18639 0.206896551724138 0.896407444813158 0.715561730578399 0.985676444105749 GO:0005506 iron ion binding 33/4302 154/18639 0.214285714285714 0.928421996413628 0.716726080579206 0.985676444105749 GO:0015645 fatty acid ligase activity 5/4302 25/18639 0.2 0.86652719665272 0.716788624899024 0.985676444105749 GO:0019211 phosphatase activator activity 5/4302 25/18639 0.2 0.86652719665272 0.716788624899024 0.985676444105749 GO:0120515 fatty acid-CoA ligase activity 5/4302 25/18639 0.2 0.86652719665272 0.716788624899024 0.985676444105749 GO:0001965 G-protein alpha-subunit binding 6/4302 30/18639 0.2 0.86652719665272 0.722858081841925 0.99300216992248 GO:0035254 glutamate receptor binding 10/4302 49/18639 0.204081632653061 0.884211425155836 0.723826587164981 0.993312793463328 GO:0099106 ion channel regulator activity 34/4302 160/18639 0.2125 0.920685146443515 0.737681641934696 1 GO:0015459 potassium channel regulator activity 12/4302 59/18639 0.203389830508475 0.881214098290901 0.73849455695545 1 GO:0008373 sialyltransferase activity 4/4302 21/18639 0.19047619047619 0.825263996812114 0.748881976112481 1 GO:0009975 cyclase activity 4/4302 21/18639 0.19047619047619 0.825263996812114 0.748881976112481 1 GO:0008013 beta-catenin binding 22/4302 106/18639 0.207547169811321 0.899226336149049 0.749938491676364 1 GO:0141108 transporter regulator activity 36/4302 170/18639 0.211764705882353 0.917499384691115 0.750024231242795 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/4302 16/18639 0.1875 0.812369246861925 0.750757797897509 1 GO:0016722 oxidoreductase activity, acting on metal ions 3/4302 16/18639 0.1875 0.812369246861925 0.750757797897509 1 GO:0017070 U6 snRNA binding 3/4302 16/18639 0.1875 0.812369246861925 0.750757797897509 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/4302 16/18639 0.1875 0.812369246861925 0.750757797897509 1 GO:0005452 solute:inorganic anion antiporter activity 6/4302 31/18639 0.193548387096774 0.838574706438116 0.753368260803081 1 GO:0098632 cell-cell adhesion mediator activity 11/4302 55/18639 0.2 0.86652719665272 0.754273747214989 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/4302 36/18639 0.194444444444444 0.8424569967457 0.757295359725226 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/4302 36/18639 0.194444444444444 0.8424569967457 0.757295359725226 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/4302 36/18639 0.194444444444444 0.8424569967457 0.757295359725226 1 GO:0002162 dystroglycan binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0004016 adenylate cyclase activity 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0008172 S-methyltransferase activity 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0008199 ferric iron binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0019215 intermediate filament binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0031731 CCR6 chemokine receptor binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0034056 estrogen response element binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0034511 U3 snoRNA binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0043522 leucine zipper domain binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0045294 alpha-catenin binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0070697 activin receptor binding 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:1990948 ubiquitin ligase inhibitor activity 2/4302 11/18639 0.181818181818182 0.787751996957018 0.760239011914266 1 GO:0009055 electron transfer activity 24/4302 116/18639 0.206896551724138 0.896407444813158 0.762383013299733 1 GO:0016597 amino acid binding 10/4302 51/18639 0.196078431372549 0.849536467306588 0.771067116733448 1 GO:0019212 phosphatase inhibitor activity 11/4302 56/18639 0.196428571428571 0.851053496712493 0.775840179507367 1 GO:0170055 lipid transmembrane transporter activity 11/4302 56/18639 0.196428571428571 0.851053496712493 0.775840179507367 1 GO:0003779 actin binding 96/4302 443/18639 0.216704288939052 0.938900799984888 0.778166984820796 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/4302 32/18639 0.1875 0.812369246861925 0.781347360197994 1 GO:0008194 UDP-glycosyltransferase activity 30/4302 145/18639 0.206896551724138 0.896407444813158 0.781740011076936 1 GO:0016247 channel regulator activity 35/4302 168/18639 0.208333333333333 0.90263249651325 0.782344294857709 1 GO:0008093 cytoskeletal anchor activity 4/4302 22/18639 0.181818181818182 0.787751996957018 0.782426917802013 1 GO:0015377 chloride:monoatomic cation symporter activity 4/4302 22/18639 0.181818181818182 0.787751996957018 0.782426917802013 1 GO:0031683 G-protein beta/gamma-subunit complex binding 4/4302 22/18639 0.181818181818182 0.787751996957018 0.782426917802013 1 GO:0023023 MHC protein complex binding 7/4302 37/18639 0.189189189189189 0.819687888725546 0.783211394305531 1 GO:0008484 sulfuric ester hydrolase activity 3/4302 17/18639 0.176470588235294 0.764582820575929 0.788214846472397 1 GO:0016018 cyclosporin A binding 3/4302 17/18639 0.176470588235294 0.764582820575929 0.788214846472397 1 GO:0031489 myosin V binding 3/4302 17/18639 0.176470588235294 0.764582820575929 0.788214846472397 1 GO:0038191 neuropilin binding 3/4302 17/18639 0.176470588235294 0.764582820575929 0.788214846472397 1 GO:0045236 CXCR chemokine receptor binding 3/4302 17/18639 0.176470588235294 0.764582820575929 0.788214846472397 1 GO:0008514 organic anion transmembrane transporter activity 57/4302 269/18639 0.211895910780669 0.91806784775474 0.791042631665126 1 GO:0003720 telomerase activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0004000 adenosine deaminase activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0005078 MAP-kinase scaffold activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0005436 sodium:phosphate symporter activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0015132 prostaglandin transmembrane transporter activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0031543 peptidyl-proline dioxygenase activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0045295 gamma-catenin binding 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0070008 serine-type exopeptidase activity 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/4302 12/18639 0.166666666666667 0.7221059972106 0.802732148364148 1 GO:0019956 chemokine binding 6/4302 33/18639 0.181818181818182 0.787751996957018 0.806851669659585 1 GO:0004896 cytokine receptor activity 19/4302 96/18639 0.197916666666667 0.857500871687587 0.81159127775459 1 GO:0004864 protein phosphatase inhibitor activity 10/4302 53/18639 0.188679245283019 0.817478487408226 0.812279000130786 1 GO:0005158 insulin receptor binding 4/4302 23/18639 0.173913043478261 0.7535019101328 0.812301312289092 1 GO:0005283 amino acid:sodium symporter activity 4/4302 23/18639 0.173913043478261 0.7535019101328 0.812301312289092 1 GO:0016493 C-C chemokine receptor activity 4/4302 23/18639 0.173913043478261 0.7535019101328 0.812301312289092 1 GO:0016849 phosphorus-oxygen lyase activity 4/4302 23/18639 0.173913043478261 0.7535019101328 0.812301312289092 1 GO:0031681 G-protein beta-subunit binding 4/4302 23/18639 0.173913043478261 0.7535019101328 0.812301312289092 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/4302 18/18639 0.166666666666667 0.7221059972106 0.820866026848827 1 GO:0031690 adrenergic receptor binding 3/4302 18/18639 0.166666666666667 0.7221059972106 0.820866026848827 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/4302 18/18639 0.166666666666667 0.7221059972106 0.820866026848827 1 GO:0070064 proline-rich region binding 3/4302 18/18639 0.166666666666667 0.7221059972106 0.820866026848827 1 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/4302 39/18639 0.179487179487179 0.777652612380646 0.828729228194772 1 GO:0008238 exopeptidase activity 20/4302 102/18639 0.196078431372549 0.849536467306588 0.829184814161802 1 GO:0001786 phosphatidylserine binding 11/4302 59/18639 0.186440677966102 0.807779590099993 0.83236785400526 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/4302 59/18639 0.186440677966102 0.807779590099993 0.83236785400526 1 GO:0070888 E-box binding 11/4302 59/18639 0.186440677966102 0.807779590099993 0.83236785400526 1 GO:0003785 actin monomer binding 5/4302 29/18639 0.172413793103448 0.747006204010965 0.832966669284357 1 GO:0004629 phospholipase C activity 5/4302 29/18639 0.172413793103448 0.747006204010965 0.832966669284357 1 GO:0005416 amino acid:monoatomic cation symporter activity 5/4302 29/18639 0.172413793103448 0.747006204010965 0.832966669284357 1 GO:0003964 RNA-directed DNA polymerase activity 2/4302 13/18639 0.153846153846154 0.666559382040554 0.83838708714319 1 GO:0019104 DNA N-glycosylase activity 2/4302 13/18639 0.153846153846154 0.666559382040554 0.83838708714319 1 GO:0071837 HMG box domain binding 2/4302 13/18639 0.153846153846154 0.666559382040554 0.83838708714319 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/4302 13/18639 0.153846153846154 0.666559382040554 0.83838708714319 1 GO:1901338 catecholamine binding 2/4302 13/18639 0.153846153846154 0.666559382040554 0.83838708714319 1 GO:0005540 hyaluronic acid binding 4/4302 24/18639 0.166666666666667 0.7221059972106 0.838724970287905 1 GO:0030215 semaphorin receptor binding 4/4302 24/18639 0.166666666666667 0.7221059972106 0.838724970287905 1 GO:0048027 mRNA 5'-UTR binding 4/4302 24/18639 0.166666666666667 0.7221059972106 0.838724970287905 1 GO:0070840 dynein complex binding 4/4302 24/18639 0.166666666666667 0.7221059972106 0.838724970287905 1 GO:0005253 monoatomic anion channel activity 20/4302 103/18639 0.194174757281553 0.841288540439534 0.842001423401627 1 GO:0042605 peptide antigen binding 8/4302 45/18639 0.177777777777778 0.77024639702464 0.84739762149578 1 GO:0046943 carboxylic acid transmembrane transporter activity 38/4302 188/18639 0.202127659574468 0.875745571085195 0.847589159218654 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/4302 19/18639 0.157894736842105 0.684100418410042 0.849118214219008 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/4302 19/18639 0.157894736842105 0.684100418410042 0.849118214219008 1 GO:0016918 retinal binding 3/4302 19/18639 0.157894736842105 0.684100418410042 0.849118214219008 1 GO:0042577 lipid phosphatase activity 3/4302 19/18639 0.157894736842105 0.684100418410042 0.849118214219008 1 GO:0043395 heparan sulfate proteoglycan binding 3/4302 19/18639 0.157894736842105 0.684100418410042 0.849118214219008 1 GO:0005343 organic acid:sodium symporter activity 6/4302 35/18639 0.171428571428571 0.742737597130903 0.850815687025313 1 GO:0016229 steroid dehydrogenase activity 6/4302 35/18639 0.171428571428571 0.742737597130903 0.850815687025313 1 GO:0022853 active monoatomic ion transmembrane transporter activity 23/4302 118/18639 0.194915254237288 0.844496844195447 0.850836892063103 1 GO:0005342 organic acid transmembrane transporter activity 38/4302 189/18639 0.201058201058201 0.871111996635009 0.856517860393559 1 GO:0003707 nuclear steroid receptor activity 4/4302 25/18639 0.16 0.693221757322176 0.861950940838168 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/4302 25/18639 0.16 0.693221757322176 0.861950940838168 1 GO:0098631 cell adhesion mediator activity 14/4302 76/18639 0.184210526315789 0.798117154811716 0.866345482660757 1 GO:0005313 L-glutamate transmembrane transporter activity 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0008191 metalloendopeptidase inhibitor activity 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0008195 phosphatidate phosphatase activity 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0031404 chloride ion binding 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0042043 neurexin family protein binding 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0043176 amine binding 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0044548 S100 protein binding 2/4302 14/18639 0.142857142857143 0.618947997609085 0.868096026655749 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/4302 36/18639 0.166666666666667 0.7221059972106 0.869519752485331 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/4302 20/18639 0.15 0.64989539748954 0.873403903014227 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/4302 20/18639 0.15 0.64989539748954 0.873403903014227 1 GO:0031418 L-ascorbic acid binding 3/4302 20/18639 0.15 0.64989539748954 0.873403903014227 1 GO:0047499 calcium-independent phospholipase A2 activity 5/4302 31/18639 0.161290322580645 0.698812255365096 0.874530718690106 1 GO:0004601 peroxidase activity 10/4302 57/18639 0.175438596491228 0.760111576011158 0.877571512976654 1 GO:0015294 solute:monoatomic cation symporter activity 22/4302 116/18639 0.189655172413793 0.821706824412062 0.879836227936415 1 GO:0001637 G protein-coupled chemoattractant receptor activity 4/4302 26/18639 0.153846153846154 0.666559382040554 0.882249872385144 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/4302 26/18639 0.153846153846154 0.666559382040554 0.882249872385144 1 GO:0004950 chemokine receptor activity 4/4302 26/18639 0.153846153846154 0.666559382040554 0.882249872385144 1 GO:0030247 polysaccharide binding 4/4302 26/18639 0.153846153846154 0.666559382040554 0.882249872385144 1 GO:0031492 nucleosomal DNA binding 7/4302 42/18639 0.166666666666667 0.7221059972106 0.882444134117862 1 GO:0005507 copper ion binding 11/4302 63/18639 0.174603174603175 0.756491997077771 0.889901923066852 1 GO:0015293 symporter activity 28/4302 146/18639 0.191780821917808 0.830916489940964 0.891059904289901 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/4302 15/18639 0.133333333333333 0.57768479776848 0.892703678980969 1 GO:0031005 filamin binding 2/4302 15/18639 0.133333333333333 0.57768479776848 0.892703678980969 1 GO:0050780 dopamine receptor binding 2/4302 15/18639 0.133333333333333 0.57768479776848 0.892703678980969 1 GO:0051371 muscle alpha-actinin binding 2/4302 15/18639 0.133333333333333 0.57768479776848 0.892703678980969 1 GO:0061891 calcium ion sensor activity 3/4302 21/18639 0.142857142857143 0.618947997609085 0.894157557497852 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/4302 27/18639 0.148148148148148 0.641871997520533 0.899897798057638 1 GO:0000146 microfilament motor activity 6/4302 38/18639 0.157894736842105 0.684100418410042 0.901078914728114 1 GO:0030246 carbohydrate binding 56/4302 280/18639 0.2 0.86652719665272 0.905556217714322 1 GO:0003954 NADH dehydrogenase activity 7/4302 44/18639 0.159090909090909 0.689282997337391 0.909795971028741 1 GO:0046982 protein heterodimerization activity 75/4302 369/18639 0.203252032520325 0.880617069769024 0.909931226665437 1 GO:0140784 metal ion sensor activity 3/4302 22/18639 0.136363636363636 0.590813997717763 0.911799237449826 1 GO:0004222 metalloendopeptidase activity 20/4302 110/18639 0.181818181818182 0.787751996957018 0.912335279842264 1 GO:0015378 sodium:chloride symporter activity 2/4302 16/18639 0.125 0.54157949790795 0.912981661992892 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/4302 16/18639 0.125 0.54157949790795 0.912981661992892 1 GO:0019841 retinol binding 2/4302 16/18639 0.125 0.54157949790795 0.912981661992892 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 2/4302 16/18639 0.125 0.54157949790795 0.912981661992892 1 GO:0008527 taste receptor activity 4/4302 28/18639 0.142857142857143 0.618947997609085 0.915166923304016 1 GO:0045499 chemorepellent activity 4/4302 28/18639 0.142857142857143 0.618947997609085 0.915166923304016 1 GO:0051959 dynein light intermediate chain binding 4/4302 28/18639 0.142857142857143 0.618947997609085 0.915166923304016 1 GO:0016298 lipase activity 24/4302 130/18639 0.184615384615385 0.799871258448664 0.915753853590867 1 GO:0008376 acetylgalactosaminyltransferase activity 5/4302 34/18639 0.147058823529412 0.637152350479941 0.920226990689297 1 GO:0015171 amino acid transmembrane transporter activity 18/4302 102/18639 0.176470588235294 0.764582820575929 0.92640270774298 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/4302 23/18639 0.130434782608696 0.5651264325996 0.926723926223937 1 GO:0005212 structural constituent of eye lens 3/4302 23/18639 0.130434782608696 0.5651264325996 0.926723926223937 1 GO:0017134 fibroblast growth factor binding 3/4302 23/18639 0.130434782608696 0.5651264325996 0.926723926223937 1 GO:0015078 proton transmembrane transporter activity 35/4302 185/18639 0.189189189189189 0.819687888725546 0.927389658880226 1 GO:0004090 carbonyl reductase (NADPH) activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0005337 nucleoside transmembrane transporter activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0015187 glycine transmembrane transporter activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0015643 toxic substance binding 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0019531 oxalate transmembrane transporter activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0031419 cobalamin binding 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0035374 chondroitin sulfate binding 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0140940 histone H2A methyltransferase activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0141109 transporter activator activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/4302 10/18639 0.1 0.43326359832636 0.927549393387579 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 22/4302 122/18639 0.180327868852459 0.781295013375403 0.927752404368617 1 GO:0043236 laminin binding 4/4302 29/18639 0.137931034482759 0.597604963208772 0.928318963947162 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/4302 132/18639 0.181818181818182 0.787751996957018 0.928881005447257 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0004550 nucleoside diphosphate kinase activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0008569 minus-end-directed microtubule motor activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0009881 photoreceptor activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0032977 membrane insertase activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0045125 bioactive lipid receptor activity 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0070492 oligosaccharide binding 2/4302 17/18639 0.117647058823529 0.509721880383953 0.929617237395625 1 GO:0015085 calcium ion transmembrane transporter activity 27/4302 147/18639 0.183673469387755 0.795790282640253 0.930923290593001 1 GO:0004180 carboxypeptidase activity 7/4302 46/18639 0.152173913043478 0.6593141713662 0.931489655130148 1 GO:0004623 phospholipase A2 activity 5/4302 35/18639 0.142857142857143 0.618947997609085 0.931795541299962 1 GO:0042287 MHC protein binding 6/4302 41/18639 0.146341463414634 0.634044290233697 0.936035748445377 1 GO:0030552 cAMP binding 3/4302 24/18639 0.125 0.54157949790795 0.93929520564337 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/4302 30/18639 0.133333333333333 0.57768479776848 0.939600591204749 1 GO:0048019 receptor antagonist activity 4/4302 30/18639 0.133333333333333 0.57768479776848 0.939600591204749 1 GO:0008509 monoatomic anion transmembrane transporter activity 27/4302 149/18639 0.181208053691275 0.785108533879981 0.941535455087841 1 GO:0015373 monoatomic anion:sodium symporter activity 2/4302 18/18639 0.111111111111111 0.4814039981404 0.943211138713975 1 GO:0050811 GABA receptor binding 2/4302 18/18639 0.111111111111111 0.4814039981404 0.943211138713975 1 GO:0008046 axon guidance receptor activity 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0010854 adenylate cyclase regulator activity 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0035252 UDP-xylosyltransferase activity 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0042285 xylosyltransferase activity 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0042608 T cell receptor binding 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0048407 platelet-derived growth factor binding 1/4302 11/18639 0.0909090909090909 0.393875998478509 0.94428043153491 1 GO:0008237 metallopeptidase activity 34/4302 184/18639 0.184782608695652 0.8005957795161 0.945569383019325 1 GO:0017147 Wnt-protein binding 4/4302 31/18639 0.129032258064516 0.559049804292077 0.949240572318029 1 GO:0005251 delayed rectifier potassium channel activity 3/4302 25/18639 0.12 0.519916317991632 0.949842150844079 1 GO:0022829 wide pore channel activity 5/4302 37/18639 0.135135135135135 0.585491349089675 0.950529933892281 1 GO:0030551 cyclic nucleotide binding 5/4302 37/18639 0.135135135135135 0.585491349089675 0.950529933892281 1 GO:0005520 insulin-like growth factor binding 2/4302 19/18639 0.105263157894737 0.456066945606695 0.954280894536912 1 GO:0008574 plus-end-directed microtubule motor activity 2/4302 19/18639 0.105263157894737 0.456066945606695 0.954280894536912 1 GO:0030506 ankyrin binding 2/4302 19/18639 0.105263157894737 0.456066945606695 0.954280894536912 1 GO:0070003 threonine-type peptidase activity 2/4302 19/18639 0.105263157894737 0.456066945606695 0.954280894536912 1 GO:0005200 structural constituent of cytoskeleton 19/4302 112/18639 0.169642857142857 0.735000747160789 0.95495463212662 1 GO:0004032 aldose reductase (NADPH) activity 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0005165 neurotrophin receptor binding 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0008179 adenylate cyclase binding 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0140900 chloride:bicarbonate antiporter activity 1/4302 12/18639 0.0833333333333333 0.3610529986053 0.957148457277707 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/4302 32/18639 0.125 0.54157949790795 0.957448240336513 1 GO:0005501 retinoid binding 5/4302 38/18639 0.131578947368421 0.570083682008368 0.958022512553518 1 GO:0019840 isoprenoid binding 5/4302 38/18639 0.131578947368421 0.570083682008368 0.958022512553518 1 GO:0043548 phosphatidylinositol 3-kinase binding 3/4302 26/18639 0.115384615384615 0.499919536530415 0.958658534990897 1 GO:0001972 retinoic acid binding 2/4302 20/18639 0.1 0.43326359832636 0.963267226928322 1 GO:0004620 phospholipase activity 18/4302 109/18639 0.165137614678899 0.715481171548117 0.963772459635233 1 GO:0015103 inorganic anion transmembrane transporter activity 29/4302 165/18639 0.175757575757576 0.761493597058451 0.965613429655507 1 GO:0015252 proton channel activity 3/4302 27/18639 0.111111111111111 0.4814039981404 0.966003627107554 1 GO:0004465 lipoprotein lipase activity 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0008417 fucosyltransferase activity 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0031432 titin binding 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0031994 insulin-like growth factor I binding 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0039706 co-receptor binding 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0140666 annealing activity 1/4302 13/18639 0.0769230769230769 0.333279691020277 0.96704523812225 1 GO:0015370 solute:sodium symporter activity 12/4302 79/18639 0.151898734177215 0.658121921508395 0.969241507963059 1 GO:0015125 bile acid transmembrane transporter activity 2/4302 21/18639 0.0952380952380952 0.412631998406057 0.970541928973634 1 GO:0020037 heme binding 24/4302 142/18639 0.169014084507042 0.732276504213566 0.971650746443594 1 GO:0005242 inward rectifier potassium channel activity 3/4302 28/18639 0.107142857142857 0.464210998206814 0.972104031563979 1 GO:0051393 alpha-actinin binding 3/4302 28/18639 0.107142857142857 0.464210998206814 0.972104031563979 1 GO:0072341 modified amino acid binding 14/4302 91/18639 0.153846153846154 0.666559382040554 0.973869366830095 1 GO:0008494 translation activator activity 1/4302 14/18639 0.0714285714285714 0.309473998804543 0.974656715927366 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/4302 14/18639 0.0714285714285714 0.309473998804543 0.974656715927366 1 GO:0032036 myosin heavy chain binding 1/4302 14/18639 0.0714285714285714 0.309473998804543 0.974656715927366 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/4302 41/18639 0.121951219512195 0.528370241861414 0.974694380175387 1 GO:0015081 sodium ion transmembrane transporter activity 28/4302 164/18639 0.170731707317073 0.73971833860598 0.976132826514946 1 GO:0033038 bitter taste receptor activity 2/4302 22/18639 0.0909090909090909 0.393875998478509 0.976416198126015 1 GO:0004181 metallocarboxypeptidase activity 3/4302 29/18639 0.103448275862069 0.448203722406579 0.977156154750535 1 GO:0017022 myosin binding 11/4302 76/18639 0.144736842105263 0.627092050209205 0.977537535403755 1 GO:0042056 chemoattractant activity 5/4302 42/18639 0.119047619047619 0.515789998007571 0.978711501257652 1 GO:0004033 aldo-keto reductase (NADPH) activity 4/4302 36/18639 0.111111111111111 0.4814039981404 0.979452495564329 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 4/4302 36/18639 0.111111111111111 0.4814039981404 0.979452495564329 1 GO:0004175 endopeptidase activity 77/4302 405/18639 0.190123456790123 0.823735730151351 0.980276041983296 1 GO:0061134 peptidase regulator activity 40/4302 226/18639 0.176991150442478 0.766838227126301 0.980313454427563 1 GO:0004129 cytochrome-c oxidase activity 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0005523 tropomyosin binding 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0008020 G protein-coupled photoreceptor activity 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0015116 sulfate transmembrane transporter activity 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0015250 water channel activity 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0030553 cGMP binding 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0033130 acetylcholine receptor binding 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0045504 dynein heavy chain binding 1/4302 15/18639 0.0666666666666667 0.28884239888424 0.98051050428068 1 GO:0004602 glutathione peroxidase activity 2/4302 23/18639 0.0869565217391304 0.3767509550664 0.981148795450022 1 GO:0099186 structural constituent of postsynapse 2/4302 23/18639 0.0869565217391304 0.3767509550664 0.981148795450022 1 GO:0033612 receptor serine/threonine kinase binding 3/4302 30/18639 0.1 0.43326359832636 0.981328995144511 1 GO:0098918 structural constituent of synapse 3/4302 30/18639 0.1 0.43326359832636 0.981328995144511 1 GO:0019838 growth factor binding 22/4302 136/18639 0.161764705882353 0.700867585527935 0.981583865044464 1 GO:0099094 ligand-gated monoatomic cation channel activity 22/4302 136/18639 0.161764705882353 0.700867585527935 0.981583865044464 1 GO:0005262 calcium channel activity 21/4302 131/18639 0.16030534351145 0.694544699607142 0.981942659775008 1 GO:0046906 tetrapyrrole binding 25/4302 152/18639 0.164473684210526 0.71260460251046 0.982608744656336 1 GO:0042805 actinin binding 4/4302 37/18639 0.108108108108108 0.46839307927174 0.982958260615486 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/4302 31/18639 0.0967741935483871 0.419287353219058 0.984767040447348 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/4302 24/18639 0.0833333333333333 0.3610529986053 0.984953667250627 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/4302 16/18639 0.0625 0.270789748953975 0.985012427099865 1 GO:0030547 signaling receptor inhibitor activity 5/4302 44/18639 0.113636363636364 0.492344998098136 0.985020016389955 1 GO:0005109 frizzled binding 4/4302 38/18639 0.105263157894737 0.456066945606695 0.985891878034541 1 GO:0015106 bicarbonate transmembrane transporter activity 3/4302 32/18639 0.09375 0.406184623430962 0.987593123217435 1 GO:0005372 water transmembrane transporter activity 1/4302 18/18639 0.0555555555555556 0.2407019990702 0.991137184558875 1 GO:0099602 neurotransmitter receptor regulator activity 1/4302 18/18639 0.0555555555555556 0.2407019990702 0.991137184558875 1 GO:0005254 chloride channel activity 11/4302 83/18639 0.132530120481928 0.57420476886626 0.991516046363311 1 GO:0004364 glutathione transferase activity 2/4302 27/18639 0.0740740740740741 0.320935998760267 0.992408447512897 1 GO:0008395 steroid hydroxylase activity 2/4302 27/18639 0.0740740740740741 0.320935998760267 0.992408447512897 1 GO:0005178 integrin binding 25/4302 161/18639 0.15527950310559 0.672769562618571 0.993301345802335 1 GO:0010851 cyclase regulator activity 1/4302 20/18639 0.05 0.21663179916318 0.994759363031943 1 GO:0015464 acetylcholine receptor activity 1/4302 20/18639 0.05 0.21663179916318 0.994759363031943 1 GO:0030627 pre-mRNA 5'-splice site binding 1/4302 20/18639 0.05 0.21663179916318 0.994759363031943 1 GO:0005272 sodium channel activity 5/4302 51/18639 0.0980392156862745 0.424768233653294 0.995847406439517 1 GO:0051428 peptide hormone receptor binding 1/4302 21/18639 0.0476190476190476 0.206315999203028 0.995970234734858 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/4302 52/18639 0.0961538461538462 0.416599613775346 0.996563246385372 1 GO:0001664 G protein-coupled receptor binding 50/4302 297/18639 0.168350168350168 0.729399997182424 0.996829077926632 1 GO:0005243 gap junction channel activity 1/4302 22/18639 0.0454545454545455 0.196937999239254 0.996901379335279 1 GO:0019199 transmembrane receptor protein kinase activity 9/4302 78/18639 0.115384615384615 0.499919536530415 0.996985605707026 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/4302 47/18639 0.0851063829787234 0.36873497729903 0.997598972315167 1 GO:0050840 extracellular matrix binding 7/4302 67/18639 0.104477611940299 0.452663460937988 0.997624809235638 1 GO:0015079 potassium ion transmembrane transporter activity 23/4302 160/18639 0.14375 0.622816422594142 0.997839032403223 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 7/4302 68/18639 0.102941176470588 0.446006645335959 0.9980098721319 1 GO:0008227 G protein-coupled amine receptor activity 3/4302 41/18639 0.0731707317073171 0.317022145116849 0.998163370391384 1 GO:0004806 triacylglycerol lipase activity 1/4302 24/18639 0.0416666666666667 0.18052649930265 0.998168003207035 1 GO:0061135 endopeptidase regulator activity 27/4302 184/18639 0.146739130434783 0.63576723667455 0.998365655260029 1 GO:0042562 hormone binding 11/4302 94/18639 0.117021276595745 0.507010593786166 0.998391383697975 1 GO:0051427 hormone receptor binding 2/4302 34/18639 0.0588235294117647 0.254860940191976 0.998515782136875 1 GO:1901681 sulfur compound binding 44/4302 275/18639 0.16 0.693221757322176 0.998603921591862 1 GO:0005021 vascular endothelial growth factor receptor activity 4/4302 51/18639 0.0784313725490196 0.339814586922635 0.998943272636251 1 GO:0046873 metal ion transmembrane transporter activity 78/4302 450/18639 0.173333333333333 0.750990237099024 0.998944866756697 1 GO:0015108 chloride transmembrane transporter activity 15/4302 121/18639 0.12396694214876 0.537103634288876 0.999030866250064 1 GO:0005104 fibroblast growth factor receptor binding 1/4302 27/18639 0.037037037037037 0.160467999380133 0.999167265491565 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/4302 60/18639 0.0833333333333333 0.3610529986053 0.999276303377933 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/4302 46/18639 0.0652173913043478 0.2825632162998 0.999388776465572 1 GO:0003777 microtubule motor activity 6/4302 68/18639 0.0882352941176471 0.382291410287965 0.999413303447144 1 GO:0008083 growth factor activity 21/4302 162/18639 0.12962962962963 0.561637997830466 0.999609766948003 1 GO:0071855 neuropeptide receptor binding 2/4302 40/18639 0.05 0.21663179916318 0.999644299774684 1 GO:0015276 ligand-gated monoatomic ion channel activity 25/4302 186/18639 0.134408602150538 0.58234354613758 0.999676155857737 1 GO:0005184 neuropeptide hormone activity 1/4302 31/18639 0.032258064516129 0.139762451073019 0.999709028249885 1 GO:0022834 ligand-gated channel activity 25/4302 188/18639 0.132978723404255 0.576148402029734 0.999751199228837 1 GO:0004497 monooxygenase activity 11/4302 106/18639 0.10377358490566 0.449613168074524 0.999774657842049 1 GO:0160041 neuropeptide activity 1/4302 32/18639 0.03125 0.135394874476987 0.99977629826649 1 GO:0004866 endopeptidase inhibitor activity 20/4302 161/18639 0.124223602484472 0.538215650094857 0.999799930329562 1 GO:0005010 insulin-like growth factor receptor activity 3/4302 51/18639 0.0588235294117647 0.254860940191976 0.999800835014155 1 GO:0005030 neurotrophin receptor activity 3/4302 51/18639 0.0588235294117647 0.254860940191976 0.999800835014155 1 GO:0003730 mRNA 3'-UTR binding 38/4302 262/18639 0.145038167938931 0.628397585358842 0.999815711249282 1 GO:0016500 protein-hormone receptor activity 5/4302 67/18639 0.0746268656716418 0.323331043527134 0.99982468447957 1 GO:0005245 voltage-gated calcium channel activity 2/4302 43/18639 0.0465116279069767 0.201517952709935 0.999827220820373 1 GO:0015020 glucuronosyltransferase activity 1/4302 34/18639 0.0294117647058824 0.127430470095988 0.999867783596678 1 GO:0019825 oxygen binding 1/4302 34/18639 0.0294117647058824 0.127430470095988 0.999867783596678 1 GO:0017046 peptide hormone binding 3/4302 53/18639 0.0566037735849057 0.245243546222468 0.999873462616255 1 GO:0038064 collagen receptor activity 3/4302 53/18639 0.0566037735849057 0.245243546222468 0.999873462616255 1 GO:0005125 cytokine activity 32/4302 234/18639 0.136752136752137 0.592497228480492 0.999897810923323 1 GO:0005267 potassium channel activity 13/4302 124/18639 0.104838709677419 0.454227965987313 0.999909220500759 1 GO:0030414 peptidase inhibitor activity 20/4302 169/18639 0.118343195266272 0.512737986185041 0.999937923284012 1 GO:0005004 GPI-linked ephrin receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0005008 hepatocyte growth factor receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0005009 insulin receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0005011 macrophage colony-stimulating factor receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0005020 stem cell factor receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0008288 boss receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0036332 placental growth factor receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0038062 protein tyrosine kinase collagen receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0060175 brain-derived neurotrophic factor receptor activity 2/4302 49/18639 0.0408163265306122 0.176842285031167 0.999959741440094 1 GO:0008201 heparin binding 20/4302 172/18639 0.116279069767442 0.503794881774837 0.999960438297125 1 GO:0005539 glycosaminoglycan binding 32/4302 242/18639 0.132231404958678 0.572910543241468 0.999963602750319 1 GO:0005006 epidermal growth factor receptor activity 2/4302 50/18639 0.04 0.173305439330544 0.999968464409748 1 GO:0005007 fibroblast growth factor receptor activity 2/4302 50/18639 0.04 0.173305439330544 0.999968464409748 1 GO:0005017 platelet-derived growth factor receptor activity 2/4302 50/18639 0.04 0.173305439330544 0.999968464409748 1 GO:0005019 platelet-derived growth factor beta-receptor activity 2/4302 50/18639 0.04 0.173305439330544 0.999968464409748 1 GO:0003735 structural constituent of ribosome 20/4302 175/18639 0.114285714285714 0.495158398087268 0.999974938822821 1 GO:0008307 structural constituent of muscle 1/4302 42/18639 0.0238095238095238 0.103157999601514 0.999983876162788 1 GO:0005003 ephrin receptor activity 2/4302 53/18639 0.0377358490566038 0.163495697481645 0.999984875093677 1 GO:0005005 transmembrane-ephrin receptor activity 2/4302 53/18639 0.0377358490566038 0.163495697481645 0.999984875093677 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/4302 53/18639 0.0377358490566038 0.163495697481645 0.999984875093677 1 GO:0004867 serine-type endopeptidase inhibitor activity 7/4302 95/18639 0.0736842105263158 0.319246861924686 0.999988449280291 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/4302 44/18639 0.0227272727272727 0.0984689996196272 0.999990473268754 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/4302 73/18639 0.0547945205479452 0.237404711411704 0.999990967011941 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/4302 56/18639 0.0357142857142857 0.154736999402271 0.999992767512399 1 GO:0005249 voltage-gated potassium channel activity 7/4302 98/18639 0.0714285714285714 0.309473998804543 0.999993706764242 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/4302 63/18639 0.0317460317460317 0.137543999468686 0.999998719778526 1 GO:0022835 transmitter-gated channel activity 2/4302 63/18639 0.0317460317460317 0.137543999468686 0.999998719778526 1 GO:0022832 voltage-gated channel activity 16/4302 175/18639 0.0914285714285714 0.396126718469815 0.99999961262681 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/4302 69/18639 0.0289855072463768 0.1255836516888 0.999999712571785 1 GO:0017171 serine hydrolase activity 19/4302 198/18639 0.095959595959596 0.415757998393982 0.999999786058446 1 GO:0005244 voltage-gated monoatomic ion channel activity 15/4302 173/18639 0.0867052023121387 0.375662079473722 0.999999833055856 1 GO:0005261 monoatomic cation channel activity 42/4302 341/18639 0.12316715542522 0.533638449551528 0.999999876106176 1 GO:0005216 monoatomic ion channel activity 60/4302 448/18639 0.133928571428571 0.580263747758518 0.999999935547301 1 GO:0022836 gated channel activity 37/4302 318/18639 0.116352201257862 0.504111733901739 0.999999949880656 1 GO:0008236 serine-type peptidase activity 17/4302 194/18639 0.0876288659793814 0.379663977914851 0.999999957534659 1 GO:0004252 serine-type endopeptidase activity 14/4302 176/18639 0.0795454545454545 0.344641498668695 0.999999973420634 1 GO:0022843 voltage-gated monoatomic cation channel activity 9/4302 143/18639 0.0629370629370629 0.272683383562045 0.999999986764078 1 GO:0001653 peptide receptor activity 7/4302 128/18639 0.0546875 0.236941030334728 0.999999988829783 1 GO:0003823 antigen binding 13/4302 174/18639 0.0747126436781609 0.323702688404752 0.999999989990246 1 GO:0030594 neurotransmitter receptor activity 3/4302 97/18639 0.0309278350515464 0.133999051028771 0.999999996277395 1 GO:0008528 G protein-coupled peptide receptor activity 5/4302 122/18639 0.040983606557377 0.17756704849441 0.999999999086952 1 GO:0005179 hormone activity 6/4302 132/18639 0.0454545454545455 0.196937999239254 0.999999999293306 1 GO:0030527 structural constituent of chromatin 1/4302 98/18639 0.0102040816326531 0.0442105712577918 0.999999999993717 1 GO:0005201 extracellular matrix structural constituent 5/4302 168/18639 0.0297619047619048 0.128947499501893 0.999999999999983 1 GO:0004984 olfactory receptor activity 1/4302 419/18639 0.00238663484486874 0.010340420007789 1 1 GO:0030371 translation repressor activity 9/4302 329/18639 0.027355623100304 0.118521956988974 1 1 GO:0045182 translation regulator activity 10/4302 356/18639 0.0280898876404494 0.121703257956843 1 1