category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	62/847	268/9376	2.56089094080953	TUBA3D/TXN/SDHD/NDUFB5/NDUFA4/DUSP1/PSMA3/NDUFB3/ATP5MC3/NDUFV2/NDUFC2/PSMA2/PSMB2/PSMA5/NDUFB8/ATP5F1C/PSMB3/NDUFA9/COX7A2L/VDAC3/UBE2L6/NDUFA8/UQCRH/SLC25A5/NDUFAB1/HSPA5/EIF2AK3/NDUFB6/CALM2/SDHC/UQCRFS1/SLC39A1/MCU/GNAI1/ATP5MC1/NDUFS4/PPIF/VDAC1/VDAC2/UCHL1/COX8A/ERN1/PSMB1/PSMB5/SDHB/SLC39A14/SLC39A6/DDIT3/PSMA6/TUBA1A/PSMD11/PSMD12/PSMA1/NDUFS3/COX6C/PSMC4/UBE2J2/NDUFB4/PSMC2/CASP3/GNAS/ATP5PO	8.16971172269687
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	73/847	368/9376	2.19588316821518	TUBA3D/SDHD/ACTG1/NDUFB5/NDUFA4/PSMA3/NDUFB3/ACTR10/ATP5MC3/NDUFV2/NDUFC2/PSMA2/CAT/PSMB2/PSMA5/NDUFB8/ATP5F1C/PSMB3/NDUFA9/COX7A2L/TNFRSF1A/CASP1/NDUFA8/UQCRH/NDUFAB1/WDR41/NUP54/HSPA5/EIF2AK3/NDUFB6/SRSF7/TANK/NUP37/SDHC/UQCRFS1/DCTN6/MCU/ATP5MC1/NDUFS4/VDAC1/PFN2/DERL1/ACTB/COX8A/ERN1/PSMB1/PSMB5/SDHB/WIPI1/NRBF2/NXT1/ALYREF/DDIT3/PSMA6/TUBA1A/TBK1/PFN1/PSMD11/HNRNPA2B1/PSMD12/UBQLN2/PSMA1/TOMM40/NDUFS3/ANXA7/COX6C/ATG101/PSMC4/NUP153/NDUFB4/PSMC2/CASP3/ATP5PO	7.37525023484398
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	44/847	174/9376	2.79922376474101	OSTC/HSPA8/HSPA1A/HSPA1B/SEC61B/BAG2/EDEM2/SEC61G/SSR3/DAD1/DNAJA1/PDIA6/HERPUD1/SAR1B/DDOST/CALR/EDEM3/HSPA5/EIF2AK3/RAD23A/UBE2D1/DNAJB11/DERL1/SSR2/HSPH1/ERN1/PDIA3/DERL2/SKP1/SEC24A/AMFR/CRYAB/DDIT3/CAPN2/DNAJC3/UBQLN2/STT3B/TRAM1/MAN1A1/UBE2J2/SEC24D/DNAJB12/P4HB/BCAP29	7.54913122358008
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	59/847	275/9376	2.37494472469679	TUBA3D/SDHD/NDUFB5/NDUFA4/HSPA8/HSPA1A/HSPA1B/PSMA3/NDUFB3/C7/ATP5MC3/NDUFV2/NDUFC2/PSMA2/PSMB2/PSMA5/NDUFB8/ATP5F1C/PSMB3/NDUFA9/COX7A2L/VDAC3/NDUFA8/UQCRH/SLC25A5/NDUFAB1/HSPA5/EIF2AK3/NDUFB6/SDHC/UQCRFS1/MCU/ATP5MC1/NDUFS4/PPIF/VDAC1/VDAC2/COX8A/CAV2/PSMB1/PSMB5/SDHB/DDIT3/PSMA6/TUBA1A/PSMD11/PSMD12/PSMA1/NDUFS3/COX6C/CREB5/PSMC4/PRNP/NDUFB4/PSMC2/CASP3/IL1A/ATP5PO/STIP1	7.29264906358249
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	74/847	388/9376	2.11122335958325	TUBA3D/SDHD/NDUFB5/NDUFA4/FAS/PSMA3/DKK1/NDUFB3/ATP5MC3/NDUFV2/NDUFC2/PSMA2/PPID/PSMB2/PSMA5/AKT1/MME/NDUFB8/ATP5F1C/PSMB3/NDUFA9/COX7A2L/VDAC3/TNFRSF1A/NDUFA8/UQCRH/SLC25A5/NDUFAB1/EIF2AK3/NDUFB6/CTNNB1/CALM2/HSD17B10/SDHC/UQCRFS1/SLC39A1/MCU/ATP5MC1/NDUFS4/PPIF/VDAC1/VDAC2/COX8A/WNT6/ERN1/PSMB1/PSMB5/SDHB/WIPI1/SLC39A14/NRBF2/SLC39A6/IKBKG/NAE1/DDIT3/PSMA6/TUBA1A/CAPN2/PLCB3/PSMD11/PSMD12/PSMA1/FADD/NDUFS3/COX6C/ATG101/PSMC4/CASP8/NDUFB4/FZD2/PSMC2/CASP3/IL1A/ATP5PO	7.04472394408514
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	63/847	308/9376	2.26424814854567	TUBA3D/SDHD/NDUFB5/SOD2/NDUFA4/PSMA3/NDUFB3/ACTR10/ATP5MC3/NDUFV2/NDUFC2/PSMA2/PSMB2/PSMA5/NDUFB8/ATP5F1C/IFT57/PSMB3/TBPL1/NDUFA9/COX7A2L/VDAC3/NDUFA8/UQCRH/SLC25A5/NDUFAB1/NDUFB6/SDHC/UQCRFS1/DCTN6/ATP5MC1/NDUFS4/CLTA/PPIF/VDAC1/VDAC2/COX8A/POLR2B/ERN1/POLR2C/PSMB1/PSMB5/SDHB/WIPI1/NRBF2/PSMA6/TUBA1A/PLCB3/PSMD11/POLR2J/PSMD12/PSMA1/NDUFS3/COX6C/ATG101/CREB5/PSMC4/CASP8/NDUFB4/PSMC2/POLR2F/CASP3/ATP5PO	7.10935523010641
Genetic Information Processing	Translation	hsa03010	Ribosome	48/847	222/9376	2.39343948434858	RPL22L1/MRPL50/RPS7/MRPL13/RPL32/RPL30/MRPL3/RPL7A/MRPL18/MRPL39/MRPL17/RPL23A/MRPL32/MRPL44/RPL26/RPL27/MRPL42/FAU/RPS10/RPS15A/RPS21/DAP3/RPS13/RPS18/MRPL15/RPLP1/MRPS28/MRPS23/MRPL47/RPS23/RPS25/MRPS22/MRPL14/MRPS35/MRPS7/RPL3/RPS4X/MRPS14/MRPL36/RPL10A/RPS12/RPL24/MRPL34/MRPL43/MRPS33/MRPL22/MRPS25/RPS24	6.62121106017461
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	81/847	480/9376	1.86800472255018	TUBA3D/SDHD/NDUFB5/NDUFA4/FAS/PSMA3/DKK1/NDUFB3/ACTR10/ATP5MC3/NDUFV2/NDUFC2/PSMA2/CAT/PPID/PSMB2/PSMA5/NDUFB8/ATP5F1C/IFT57/PSMB3/NDUFA9/COX7A2L/VDAC3/TNFRSF1A/UBE2L6/NDUFA8/UQCRH/SLC25A5/NDUFAB1/WDR41/HSPA5/EIF2AK3/NDUFB6/CTNNB1/TANK/CALM2/HSD17B10/SDHC/UQCRFS1/DCTN6/MCU/ATP5MC1/NDUFS4/PPIF/VDAC1/VDAC2/DERL1/UCHL1/COX8A/WNT6/ERN1/PSMB1/PSMB5/SDHB/WIPI1/NRBF2/DDIT3/PSMA6/TUBA1A/CAPN2/TBK1/PLCB3/PSMD11/PSMD12/PSMA1/FADD/TOMM40/NDUFS3/COX6C/ATG101/PSMC4/UBE2J2/PRNP/CASP8/NDUFB4/FZD2/PSMC2/CASP3/IL1A/ATP5PO	6.15210311132257
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	47/847	227/9376	2.29195554145494	SDHD/NDUFB5/SOD2/MGST1/NDUFA4/NDUFB3/ATP5MC3/NDUFV2/NDUFC2/CAT/NQO1/AKT1/MGST3/NDUFB8/ATP5F1C/NFKBIA/NDUFA9/COX7A2L/VDAC3/NDUFA8/UQCRH/SLC25A5/NDUFAB1/GSTO1/NDUFB6/PTEN/ACP1/SDHC/UQCRFS1/ATP5MC1/NDUFS4/PPIF/VDAC1/VDAC2/GSTM3/COX8A/SDHB/CBR1/IKBKG/GSTT2B/MGST2/GSTA4/NDUFS3/COX6C/PRKD3/NDUFB4/ATP5PO	6.20943335199666
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	34/847	157/9376	2.39725069371856	SDHD/NDUFB5/NDUFA4/FAS/NDUFB3/NDUFV2/NDUFC2/CXCL8/AKT1/NDUFB8/CDC42/NDUFA9/COX7A2L/TNFRSF1A/NDUFA8/UQCRH/NDUFAB1/SOCS3/EIF2AK3/NDUFB6/SDHC/UQCRFS1/NDUFS4/ADIPOR1/COX8A/ERN1/SDHB/DDIT3/NDUFS3/COX6C/CASP8/NDUFB4/CASP3/IL1A	5.56365944608083
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/847	205/9376	2.15993319319262	SDHD/NDUFB5/NDUFA4/NDUFB3/ATP5MC3/NDUFV2/NDUFC2/AKT1/PPP1CB/NDUFB8/ATP5F1C/MMP2/NDUFA9/COX7A2L/VDAC3/NDUFA8/UQCRH/SLC25A5/NDUFAB1/COL3A1/NDUFB6/PTEN/SDHC/UQCRFS1/ATP5MC1/NDUFS4/PPP1CC/COL1A2/PPIF/VDAC1/VDAC2/COX8A/SDHB/MPC2/PLCB3/MPC1/NDUFS3/COX6C/NDUFB4/ATP5PO	5.29151274569545
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/847	138/9376	2.40644730763308	SDHD/NDUFB5/NDUFA4/NDUFB3/COX11/ATP5MC3/NDUFV2/NDUFC2/NDUFB8/ATP5F1C/ATP6V0E1/NDUFA9/COX7A2L/NDUFA8/UQCRH/NDUFAB1/ATP6V1G1/PPA2/NDUFB6/SDHC/UQCRFS1/ATP5MC1/NDUFS4/COX8A/SDHB/NDUFS3/COX6C/NDUFB4/PPA1/ATP5PO	5.24508241323147
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	15/847	46/9376	3.60967096144962	PSMA3/PSMA2/PSMB2/PSMA5/PSMB3/PSMB9/PSMB8/PSMB1/PSMB5/PSMA6/PSMD11/PSMD12/PSMA1/PSMC4/PSMC2	5.59116273872384
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	44/847	248/9376	1.96397151235861	TUBA3D/TXN/ACTG1/MYC/RIPK2/DYNLL1/MYL12B/ARPC1A/ACTR10/CXCL8/DYNLT3/AKT1/ARL8A/ARPC3/NFKBIA/CDC42/MYL12A/TNFRSF1A/CASP1/RAB9A/CTNNB1/DYNLT1/DCTN6/STX10/PFN2/ACTB/RHOB/ANXA2/SKP1/BRK1/M6PR/ACTR3/IKBKG/TUBA1A/RRAS/PAK3/LY96/PFN1/FADD/CASP8/WASL/CASP3/SNX18/ARL8B	4.84819981359811
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	16/847	56/9376	3.16275931860347	OSTC/DAD1/ALG14/MGAT2/DPM1/DDOST/ALG1/ALG5/ALG2/MGAT4B/SRD5A3/STT3B/MAN1A1/B4GALT3/DPAGT1/ALG10	5.1153167994667
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	34/847	180/9376	2.09093532729896	PILRA/OAS1/FAS/SRSF9/IFNGR1/B2M/IFNGR2/AKT1/PPP1CB/NFKBIA/IRF7/TNFRSF1A/CALR/SOCS3/SRSF7/RHEB/EIF2B2/TAP1/PPP1CC/SRSF1/HLA-F/PDIA3/OAS2/HLA-DOB/IKBKG/ALYREF/TAP2/EIF2B3/TBK1/FADD/CGAS/CASP8/CASP3/RNASEL	4.65708390971382
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/847	235/9376	1.93130196689191	SDHD/ACTG1/NDUFB5/NDUFA4/NDUFAF4/NDUFB3/COX11/COA6/ATP5MC3/COA4/NDUFV2/NDUFC2/NDUFB8/ATP5F1C/NDUFA9/COX7A2L/NDUFA8/UQCRH/NDUFAB1/NDUFB6/NDUFAF1/RHEB/SDHC/UQCRFS1/ATP5MC1/NDUFS4/ACTB/COX8A/SDHB/ACTL6A/COA1/NDUFS3/COX6C/CREB5/NDUFB4/DPF1/ADCY3/SMARCE1/GNAS/COA5/ATP5PO	4.556232556816
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/847	30/9376	4.05887445887446	SDHD/MDH1/FH/SDHC/SUCLA2/MDH2/ACO1/SDHB/IDH3A/SUCLG2/DLD	5.28795411961019
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	24/847	116/9376	2.29027398933355	SDHD/CAT/MDH1/ADH5/FH/PGAM1/SDHC/RPE/SUCLA2/GCSH/MDH2/ESD/ECHS1/ACO1/SDHB/PFKM/PGP/GOT1/TKT/MCEE/IDH3A/SUCLG2/DLD/HIBCH	4.40639808506645
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/847	56/9376	2.96508686119076	CXCL1/HSPA8/HSPA1A/HSPA1B/SEC22B/CXCL8/NFKBIA/SAR1B/EEF1A1/CASP1/HSPD1/HBS1L/CXCL2/CASP8/CASP3	4.64778569995996
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/847	142/9376	2.10479405357766	CDC26/UBE2N/CUL2/SIAH1/UBE2L6/UBE2A/SOCS1/SOCS3/UBE2I/ELOC/UBE2S/UBA2/UBE2D1/CUL3/UBE2QL1/UBE2M/UBE2B/FANCL/SKP1/UBE2E3/UBE2F/UBA3/UBE2W/UBE2J2/RNF7/SAE1/KLHL13	4.18031348693751
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/847	142/9376	2.10479405357766	TXN/ACTG1/MGST1/VCAM1/DUSP1/NQO1/SUMO2/AKT1/MGST3/MMP2/SUMO1/TNFRSF1A/GSTO1/CTNNB1/CALM2/GSTM3/KLF2/ACTB/CAV2/IL1R1/SDC4/IKBKG/GSTT2B/MGST2/GSTA4/MAPK7/IL1A	4.18031348693751
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/847	78/9376	2.55453637271819	LSM8/LSM1/LSM6/LSM5/EXOSC3/C1D/CNOT8/HSPD1/EXOSC7/MPHOSPH6/EXOSC8/BTG2/PFKM/EXOSC1/HSPA9/LSM2/BTG3/PATL1	4.34441900228919
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/847	238/9376	1.81393549155199	RPL22L1/RPS7/ACE2/OAS1/RPL32/RPL30/RPL7A/C7/RPL23A/RPL26/RPL27/CXCL8/FAU/CSF3/RPS10/NFKBIA/RPS15A/RPS21/TNFRSF1A/RPS13/ISG15/RPS18/CASP1/CFD/RPLP1/RPS23/RPS25/MX1/RPL3/OAS2/RPS4X/IKBKG/RPL10A/RPS12/NRP1/RPL24/TBK1/CGAS/RPS24	4.00803194288439
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	27/847	144/9376	2.07556080283353	PSMA3/PSMA2/PSMB2/PSMA5/AKT1/GTF2B/PSMB3/TBPL1/VDAC3/SLC25A5/MCU/PPIF/VDAC1/VDAC2/ERN1/PSMB1/PSMB5/WIPI1/NRBF2/PSMA6/PLCB3/PSMD11/PSMD12/PSMA1/ATG101/PSMC4/PSMC2	4.09870442801875
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/847	31/9376	3.57085729519747	SEC61B/SRP9/SEC61G/SRP54/SPCS3/HSPA5/SRPRA/SEC11A/SPCS1/SRPRB	4.51801273182303
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/847	82/9376	2.42992484234169	MGST1/NAT1/MGST3/CYP2A7/UPP2/GSTO1/DUT/GSTM3/NME7/HPRT1/CES1/TPMT/CMPK1/UCKL1/GSTT2B/MGST2/GSTA4/ITPA	4.09823718544231
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/847	173/9376	1.85560734588585	ACTG1/OAS1/FAS/IFNGR1/IFNGR2/CXCL8/AKT1/NFKBIA/IRF7/TNFRSF1A/CASP1/SLC25A5/SOCS3/VDAC1/ACTB/MX1/OAS2/HLA-DOB/NXT1/IKBKG/CPSF4/DNAJC3/TBK1/FADD/CDK4/CASP8/CASP3/IL1A/RNASEL	3.57940739740209
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/847	157/9376	1.90369908030591	MYC/GADD45A/PPID/CHEK1/CXCL8/AKT1/PPP1CB/VDAC3/TRAF3IP2/SLC25A5/CHEK2/PTEN/RHEB/CALM2/MCU/PPP1CC/VDAC1/ZFP36L1/VDAC2/HLA-F/CCND2/RRAS/CAPN2/CDK4/SERPINE1/GADD45B/IL1A	3.59840503007924
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/847	85/9376	2.21393152302243	NTPCR/AK6/NT5E/UPP2/DCTD/DUT/DGUOK/NME7/HPRT1/ENTPD3/ADA/CMPK1/HDDC2/UCKL1/ITPA/CMPK2/DCK	3.54283321931326
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/847	44/9376	2.76741440377804	OSTC/DAD1/ALG14/MGAT2/DDOST/ALG1/ALG2/MGAT4B/STT3B/MAN1A1/B4GALT3	3.70301651841756
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/847	44/9376	2.76741440377804	GTF2A2/GTF2B/TBPL1/TAF12/CCNH/TAF10/GTF2H5/TAF9/TAF7/GTF2H1/GTF2F2	3.70301651841756
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/847	205/9376	1.72794655455409	VIM/MYC/OAS1/FAS/GADD45A/B2M/AKT1/SAP30/NFKBIA/IRF7/ISG15/CALR/TAP1/CDKN1B/HLA-F/PDIA3/OAS2/CCND2/HLA-DOB/IKBKG/TAP2/ENTPD3/TBK1/PSMD11/PSMD12/FADD/CDK4/PSMC4/CASP8/GADD45B/PSMC2/CASP3	3.3208278668239
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/847	32/9376	3.1133412042503	LDHB/SUCLA2/LDHA/ECHS1/ACSS3/MCEE/SUCLG2/DLD/HIBCH	3.77360536850253
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/847	216/9376	1.69119769119769	SOD2/CXCL1/HSPA8/VCAM1/FAS/HSPA1A/HSPA1B/CXCL8/AKT1/NFKBIA/IRF7/CDC42/RAP1B/TNFRSF1A/CASP1/CYP2A7/HSPA5/EIF2AK3/TANK/CALM2/LBP/CYP2B6/HSPD1/ERN1/CXCL2/HSPA4/IKBKG/DDIT3/TBK1/LY96/PLCB3/CASP8/CASP3	3.23861783876817
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/847	75/9376	2.21393152302243	FAS/GADD45A/CHEK1/SIAH1/CHEK2/PTEN/GORAB/CCND2/CCNG2/CCNG1/CDK4/SERPINE1/CASP8/GADD45B/CASP3	3.32612284286104
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/847	47/9376	2.59077093119646	MDH1/ADH5/ADH1B/LDHB/FH/MDH2/LDHA/ALDH3A2/ACYP1/DLD/ALDH2	3.44522281811581
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/847	48/9376	2.53679653679654	AOX1/HSD17B10/HIBADH/ECHS1/ALDH3A2/HADHB/ACAA2/MCEE/DLD/ALDH2/HIBCH	3.36372907632654
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/847	101/9376	1.97281026803979	F3/VCAM1/CXCL8/AKT1/MMP2/CDC42/COL3A1/VEGFB/COL4A1/COL1A2/VEGFC/CDKN1B/COL4A5/PLCB3/CDK4/SERPINE1/CASP3/IL1A	3.09749176085015
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/847	31/9376	2.85668583615798	CAT/MDH1/GCSH/MDH2/ACO1/PGP/MCEE/DLD	3.26293110956705
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/847	187/9376	1.65748884076546	TXN/GBP1/CXCL1/RIPK2/OAS1/ATG5/TXNIP/CXCL8/NFKBIA/ANTXR1/IRF7/VDAC3/CASP1/TANK/MCU/VDAC1/VDAC2/GBP3/GABARAPL2/OAS2/CXCL2/NAMPT/IKBKG/TBK1/PLCB3/FADD/CASP8/RNASEL	2.86189271946645
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/847	59/9376	2.25145578612451	NT5E/UPP2/DCTD/DUT/NME7/ENTPD3/CMPK1/HDDC2/UCKL1/CMPK2/DCK/NUDT2	3.0386575222925
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/847	224/9376	1.58137965930174	ZFP36/MYC/IL15RA/B2M/CHEK1/CDC26/AKT1/RAN/NFKBIA/TBPL1/VDAC3/TNFRSF1A/SLC25A5/CALR/CHEK2/PTEN/NFYB/RANBP1/VDAC1/VDAC2/BUB3/HLA-F/IL1R1/CCND2/ESPL1/HLA-DOB/IL15/IKBKG/NRP1/CDK4/CREB5/ADCY3	2.77526285299621
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/847	227/9376	1.56048036865017	MYC/GNG4/FAS/B2M/CXCL8/AKT1/NFKBIA/TNFRSF1A/PDGFRA/GNG5/CALR/CTNNB1/RHEB/CALM2/TAP1/GNAI1/HLA-F/PDIA3/IL1R1/GNB2/IKBKG/TAP2/TBK1/PLCB3/FADD/CDK4/CGAS/CREB5/CASP8/ADCY3/CASP3/GNAS	2.69379663816949
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	13/847	70/9376	2.05579355709226	MGST1/NAT1/CYP2A13/MGST3/CYP2A7/GSTO1/GSTM3/HSD11B1/CBR1/SULT1A1/GSTT2B/MGST2/GSTA4	2.79398962748425
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/847	34/9376	2.60462532120286	POLR3K/POLR2B/POLR2C/POLR1C/POLR1B/POLR1D/POLR2J/POLR2F	2.95373449119896
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/847	94/9376	1.88419704087016	CEBPB/CXCL1/CXCL8/CSF3/JUND/NFKBIA/TRAF3IP2/SRSF1/CXCL2/IKBKG/TBK1/FADD/CASP8/ELAVL1/MAPK7/CASP3	2.71500408923818
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/847	214/9376	1.55182116099703	GNG4/TRIM5/FAS/B2M/CHEK1/AKT1/NFKBIA/TNFRSF1A/GNG5/CALR/ELOC/AP1S1/CALM2/TAP1/GNAI1/APOBEC3B/HLA-F/PDIA3/SKP1/CFL2/GNB2/IKBKG/TAP2/PAK3/TBK1/FADD/CGAS/CASP8/RNF7/CASP3	2.5732879108102
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/847	136/9376	1.70928536703938	HSPA8/OAS1/FAS/HSPA1A/HSPA1B/AKT1/NFKBIA/IRF7/RAB9A/EIF3H/CDKN1B/MX1/OAS2/CCND2/IKBKG/TBK1/FADD/CDK4/CASP8/CASP3/IL1A	2.62562533887437
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/847	79/9376	1.96171147609583	MGST1/CYP2A13/ADH5/ADH1B/MGST3/CYP2A7/GSTO1/CYP2B6/GSTM3/HSD11B1/CBR1/GSTT2B/MGST2/GSTA4	2.70498720292659
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/847	156/9376	1.63206490479218	IFIT1/MYC/CLDN10/OAS1/FAS/CLDN23/AKT1/NFKBIA/IRF7/TNFRSF1A/SOCS3/CTNNB1/MX1/OAS2/IKBKG/TBK1/FADD/CDK4/YWHAQ/CASP8/EIF3E/CASP3/RNASEL	2.50863109849032
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/847	43/9376	2.31690508223278	ADH5/ADH1B/ACADVL/ECI1/ECHS1/ALDH3A2/HADHB/ACAA2/ALDH2	2.72744721763316
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/847	59/9376	2.06383447061413	MGST1/ODC1/MGST3/GSTO1/PRDX6/GSTM3/GGT5/GSTT2B/MGST2/GSTA4/CHAC2	2.58309454672502
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/847	83/9376	1.86717116399482	NFKBIA/IRF7/CASP1/POLR3K/POLR1C/POLR1D/IKBKG/TBK1/FADD/CGAS/CASP8/POLR2F/CASP3/G3BP1	2.50059979726648
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/847	144/9376	1.61432506887052	CXCL1/FAS/ADH5/ADH1B/CXCL8/AKT1/NFKBIA/TNFRSF1A/ACADVL/CTNNB1/LBP/ADIPOR1/CXCL2/ALDH3A2/IKBKG/TBK1/LY96/FADD/CASP8/ALDH2/CASP3	2.34104559536673
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/847	93/9376	1.78542864759874	MYC/CKS2/GADD45A/LAMA2/AKT1/NFKBIA/PTEN/COL4A1/CDKN1B/COL4A5/IKBKG/CKS1B/CDK4/GADD45B/CASP3	2.39873528081026
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/847	253/9376	1.44386838457985	ACTG1/RIPK2/MYL12B/ATG5/ARPC1A/PPID/CXCL8/AKT1/UBE2N/ARPC3/NFKBIA/CDC42/MYL12A/TNFRSF1A/CASP1/BCL10/RRAGA/VDAC1/UBE2D1/PFN2/ACTB/IL1R1/SKP1/UBE2V2/WIPI1/ACTR3/IKBKG/CAPN2/TBK1/PFN1/PLCB3/CGAS/WASL	2.2554017960659
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/847	119/9376	1.67440199220184	CEBPB/CXCL1/VCAM1/FAS/JUNB/MAP3K8/AKT1/NFKBIA/TNFRSF1A/SOCS3/VEGFC/CXCL2/IL15/IKBKG/FADD/CREB5/CASP8/CASP3	2.33311142045482
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/847	137/9376	1.61600841096528	TUBA3D/ACTG1/FAS/GADD45A/AKT1/NFKBIA/TNFRSF1A/CTSK/EIF2AK3/ACTB/ERN1/IKBKG/DDIT3/NGF/TUBA1A/CAPN2/FADD/CASP8/GADD45B/CASP3	2.28882573663248
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/847	112/9376	1.6802158880081	HSPA8/HSPA1A/HSPA1B/LAMA2/IFNGR1/IFNGR2/AKT1/NFKBIA/TNFRSF1A/SOCS1/GNAI1/PPIF/HLA-DOB/IKBKG/LY96/CASP8/CASP3	2.28210065679694
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/847	105/9376	1.68680496992185	CXCL1/VCAM1/GADD45A/PLAU/CXCL8/NFKBIA/TNFRSF1A/BCL10/UBE2I/LBP/IL1R1/CXCL2/IKBKG/LY96/GADD45B/CCL21	2.23019621462249
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/847	250/9376	1.41691617473436	HSPA8/HSPA1A/ARF4/HSPA1B/SNX3/ARPC1A/WASHC3/CAPZA2/ARPC3/CDC42/VPS29/PDGFRA/SPART/VPS37A/STAM/SNX2/TSG101/CLTA/CHMP5/PARD6G/HLA-F/STAMBP/CAV2/SNF8/ACTR3/VPS45/RAB4A/SNX4/ARFGAP3/WASL/PDCD6IP/STAM2	2.10550754810716
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	12/847	73/9376	1.81966974494994	MGST1/ADH5/ADH1B/MGST3/AOX1/CYP2A7/GSTO1/CYP2B6/GSTM3/GSTT2B/MGST2/GSTA4	2.21547631135331
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/847	82/9376	1.754945719469	HSPA8/HSPA1A/HSPA1B/B2M/CALR/HSPA5/NFYB/TAP1/HLA-F/PDIA3/HLA-DOB/HSPA4/TAP2	2.16371275531629
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/847	170/9376	1.49765955969165	ACTG1/MYC/MGST1/GADD45A/NQO1/AKT1/MGST3/GSTO1/PTEN/CTNNB1/GSTM3/ACTB/WNT6/ACTL6A/TXNRD1/GSTT2B/MGST2/GSTA4/CDK4/FZD2/GADD45B/DPF1/SMARCE1	2.06347690524323
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/847	75/9376	1.77114521841795	MGST1/FAS/AKT1/MGST3/GSTO1/GSTM3/GSTT2B/MGST2/GSTA4/FADD/CASP8/CASP3	2.11290643458774
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/847	67/9376	1.81740647412289	MINPP1/ADH5/ADH1B/LDHB/PGAM1/LDHA/PGM2/ALDH3A2/PFKM/DLD/ALDH2	2.1159346255582
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/847	200/9376	1.43905548996458	TUBA3D/ACTG1/CLDN10/FAS/ARPC1A/CXCL8/CLDN23/ARPC3/NFKBIA/CDC42/TNFRSF1A/CASP1/ACTB/IL1R1/NCK1/BRK1/SEC24A/ACTR3/IKBKG/TUBA1A/PAK3/FADD/SEC24D/CASP8/WASL/CASP3	1.97781649004951
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/847	51/9376	1.95346899090215	ACTG1/SEC61B/SEC61G/ATP6V0E1/KDELR2/ATP6V1G1/ACTB/ADCY3/GNAS	2.15152069233309
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	18/847	128/9376	1.55667060212515	NTPCR/AK6/NT5E/DGUOK/PAICS/NME7/PGM2/HPRT1/PDE4B/ENTPD3/ADA/HDDC2/ATIC/ITPA/ADCY3/DCK/NUDT2/PPAT	1.99828600676512
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/847	103/9376	1.61208606045323	FAS/IFNGR1/IFNGR2/CXCL8/AKT1/NFKBIA/TNFRSF1A/CALR/GNAI1/IKBKG/PLCB3/FADD/SERPINE1/CASP8/GNAS	1.96833610006153
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/847	130/9376	1.53272182363091	GNG4/AKT1/NFKBIA/MMP2/GNG5/COL3A1/VEGFB/COL4A1/GNAI1/COL1A2/VEGFC/COL4A5/GNB2/EDNRB/PLCB3/CREB5/ADCY3/GNAS	1.92740733023127
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/847	196/9376	1.41194612437655	ZFP36/MYC/GNG4/CXCL1/FAS/IFNGR1/FGF2/CXCL8/AKT1/NFKBIA/IRF7/TNFRSF1A/GNG5/CLEC2B/CTNNB1/CALM2/HLA-F/CXCL2/GNB2/IKBKG/TBK1/FADD/CDK4/CASP8/CASP3	1.83664576852641
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/847	17/9376	2.60462532120286	SCP2/CYP7B1/CYP39A1/HSD17B4	2.08670791982227
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/847	17/9376	2.60462532120286	SEPHS2/SEPHS1/TXNRD1/PSTK	2.08670791982227
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/847	108/9376	1.53745244654336	SUMO2/EIF4A3/RAN/SUMO1/EEF1A1/UBE2I/NUP54/NUP37/MAGOH/MAGOHB/NXT1/ALYREF/PYM1/NUP153/THOC3	1.77026056732756
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/847	157/9376	1.41014746689327	ACTG1/MYC/PPP1CB/SNAI2/BMP2/CTNNB1/PPP1CC/PARD6G/ACTB/WTIP/WNT6/CCND2/FRMD6/MOB1A/ID2/SERPINE1/ID1/YWHAQ/TEAD3/FZD2	1.63315061407763
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/847	50/9376	1.77114521841795	L3HYPDH/ODC1/P4HA3/ALDH3A2/GOT1/OAT/CKMT2/ALDH2	1.72286700099475
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/847	149/9376	1.41156707843712	NDUFB5/GNG4/NDUFA4/NDUFB3/NDUFV2/NDUFC2/NDUFB8/NDUFA9/GNG5/NDUFA8/NDUFAB1/NDUFB6/GNAI1/NDUFS4/GNB2/PLCB3/NDUFS3/NDUFB4/ADCY3	1.59581222594185
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/847	103/9376	1.50461365642301	EIF4A3/PPP1CB/PELO/PPP1CC/MAGOH/HBS1L/CPSF6/MAGOHB/NXT1/ALYREF/PYM1/CPSF4/CSTF1/WDR33	1.62272814346727
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/847	20/9376	2.21393152302243	SOAT2/HSD17B7/CYP27B1/MSMO1	1.71254647672618
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/847	232/9376	1.28827911900012	ACTG1/TMSB4X/MYL12B/ARPC1A/C7/FGF2/AKT1/ARPC3/PPP1CB/ITGAE/CDC42/MYL12A/PDGFRA/RGCC/PPP1CC/ITGB5/BDKRB1/PFN2/GSN/ACTB/BRK1/CFL2/ACTR3/RRAS/PAK3/PFN1/WASL	1.40109426713059
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/847	28/9376	1.97672457412717	PTS/GGH/PCBD1/MOCS2/CBR1	1.63106047815036
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/847	62/9376	1.60688578283886	SOD2/HSPA8/HSPA1A/HSPA1B/ATG5/CAT/AKT1/CRYAB/ADCY3	1.51082087818442
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/847	63/9376	1.58137965930174	RAD23A/CCNH/POLR2B/POLR2C/GTF2H5/RPA3/POLR2J/GTF2H1/POLR2F	1.45902788582646
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/847	72/9376	1.53745244654336	ATG5/CXCL8/NFKBIA/IRF7/ISG15/TANK/IKBKG/TBK1/FADD/CASP8	1.44261262203446
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/847	21/9376	2.10850621240232	CHST7/CHST11/B4GALT7/DSEL	1.60252262212575
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/847	110/9376	1.40886551465064	BAMBI/DCN/MYC/ID3/LEFTY2/FST/BMP2/ID4/SKP1/TGIF1/ID2/FMOD/ID1/TFDP1	1.3592801123477
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/847	73/9376	1.51639145412495	TRIM5/RAN/PPIA/TSG101/CPSF6/APOBEC3B/MX1/CCNT2/NUP153/PDCD6IP	1.3957487647284
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/847	38/9376	1.74784067607034	NNMT/AOX1/NT5E/BST1/NAMPT/NUDT12	1.45563414051779
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	11/847	83/9376	1.4670630574245	SOD2/CAT/SCP2/MPV17L2/PRDX1/PEX13/PHYH/FAR1/NUDT12/CROT/HSD17B4	1.34683651302011
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/847	30/9376	1.84494293585203	PIGF/PIGK/PIGG/PIGP/PIGH	1.46067435540271
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/847	103/9376	1.3971412523928	CXCL1/LAMA2/CXCL8/COL3A1/COL4A1/COL1A2/PRDX1/IL1R1/CXCL2/COL4A5/PLCB3/CASP3/GNAS	1.27712018687301
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/847	31/9376	1.78542864759874	RPE/DERA/PGM2/PFKM/TKT	1.38030867618308
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/847	31/9376	1.78542864759874	GAD1/ECHS1/ALDH3A2/ALDH2/HIBCH	1.38030867618308
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/847	23/9376	1.92515784610646	ACE2/MME/ATP6AP2/ENPEP	1.39985345444324
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/847	203/9376	1.25419766082552	ACTG1/MYL12B/LAMA2/AKT1/PPP1CB/CDC42/RAP1B/MYL12A/PDGFRA/PTEN/CTNNB1/VEGFB/COL4A1/PPP1CC/COL1A2/ITGB5/VEGFC/ACTB/CAV2/CCND2/COL4A5/CAPN2/PAK3	1.15383088087735
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/847	204/9376	1.24804963307637	ACTG1/DCN/MYC/TWIST1/FAS/FGF2/PLAU/AKT1/PPP1CB/MMP2/CDC42/CTNNB1/PPP1CC/COL1A2/ITGB5/ACTB/WNT6/CAV2/SDC4/RRAS/HPSE/FZD2/CASP3	1.12875564636163
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/847	68/9376	1.46510174317661	ALDH1A1/ADH5/ADH1B/AOX1/CYP2A7/ALDH1A3/CYP2B6/RDH10/HSD17B6	1.21297687826013
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/847	32/9376	1.72963400236128	ATG5/GABARAPL2/WIPI1/ATG101/ATG4C	1.30284252387406
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/847	155/9376	1.28550862627109	TUBA3D/ACTG1/SEC61B/SEC61G/SEC22B/ATP6V0E1/CALR/ATP6V1G1/COLEC11/TAP1/ITGB5/ACTB/HLA-F/HLA-DOB/M6PR/TAP2/TUBA1A/VAMP3	1.12946911211817
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/847	78/9376	1.41918687373233	ACTG1/ARPC1A/ARPC3/CDC42/CTNNB1/CLTA/ACTB/CAV2/ACTR3/WASL	1.1714897455687
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/847	42/9376	1.58137965930174	CAT/AOX1/ECHS1/ALDH3A2/DLD/ALDH2	1.18995041868171
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/847	42/9376	1.58137965930174	ATG5/VDAC3/SLC3A2/VDAC2/SLC39A14/PRNP	1.18995041868171
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/847	70/9376	1.42324169337156	ACTG1/LAMA2/SGCB/ACTB/HLA-F/HLA-DOB/SNTB1/CASP8/CASP3	1.12004178587319
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/847	158/9376	1.26110023463303	MYC/GADD45A/CHEK1/CDC26/MAD2L1BP/CHEK2/CCNH/CDKN1B/BUB3/SKP1/CCND2/ESPL1/CDK4/YWHAQ/TFDP1/GADD45B/CDC14A/NDC80	1.0430274539943
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/847	109/9376	1.32023439446292	CXCL8/MAP3K8/AKT1/NFKBIA/IRF7/CTSK/LBP/CXCL9/IKBKG/TBK1/LY96/FADD/CASP8	1.05971706669291
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/847	71/9376	1.40319603571844	CXCL1/CXCL8/NFKBIA/ATP6V0E1/CDC42/ATP6V1G1/CXCL2/IKBKG/CASP3	1.07464624418679
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/847	71/9376	1.40319603571844	MYC/AKT1/LDHB/PDGFRA/PGAM1/PTEN/LDHA/PFKM/TIGAR	1.07464624418679
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/847	17/9376	1.95346899090215	CDO1/GAD1/GGT5	1.23992265878554
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/847	44/9376	1.50949876569711	FAS/GAD1/HSPD1/HLA-F/HLA-DOB/IL1A	1.0674815942751
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	23/847	212/9376	1.20095342050745	ACTG1/FGF2/AKT1/CDC42/RAP1B/PDGFRA/CTNNB1/VEGFB/CALM2/GNAI1/VEGFC/PFN2/PARD6G/ACTB/RALB/NGF/RRAS/PFN1/PLCB3/ID1/PRKD3/ADCY3/GNAS	0.932607876955161
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/847	54/9376	1.4349556167738	CDO1/MDH1/LDHB/APIP/MDH2/LDHA/GOT1	1.01010276570264
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/847	93/9376	1.30931434157241	ACTG1/MYL12B/CDC42/SNAI2/RAP1B/MYL12A/CTNNB1/ACP1/ACTB/SNAI1/WASL	0.94466025177297
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/847	45/9376	1.47595434868162	ABCA8/TAP1/ABCA6/TAP2/ABCC5/ABCC9	1.00852286190604
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/847	18/9376	1.84494293585203	THAP11/PRDX1/LMBRD1	1.13070782494635
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/847	37/9376	1.49589967771786	GAD1/FOLH1/GOT1/NIT2/PPAT	0.952407455741907
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/847	37/9376	1.49589967771786	COMT/ADH5/ADH1B/AOX1/GOT1	0.952407455741907
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/847	37/9376	1.49589967771786	UAP1/PGM2/UXS1/TGDS/CMAS	0.952407455741907
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/847	37/9376	1.49589967771786	MYC/GADD45A/TFG/CTNNB1/GADD45B	0.952407455741907
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/847	300/9376	1.14386462022826	MYC/HSPA8/DUSP1/FAS/HSPA1A/HSPA1B/CACNA2D1/GADD45A/FGF2/MAP3K8/AKT1/JUND/CDC42/RAP1B/TNFRSF1A/PDGFRA/NTF3/DUSP5/VEGFB/VEGFC/IL1R1/LAMTOR3/IKBKG/DDIT3/NGF/CACNA2D3/RRAS/GADD45B/MAPK7/CASP3/IL1A	0.79807861451706
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/847	28/9376	1.58137965930174	HACD1/ECHS1/HADHB/ACAA2	0.970862626175841
Organismal Systems	Immune system	hsa04611	Platelet activation	14/847	126/9376	1.22996195723468	ACTG1/MYL12B/AKT1/PPP1CB/RAP1B/MYL12A/COL3A1/GNAI1/PPP1CC/COL1A2/ACTB/PLCB3/ADCY3/GNAS	0.818933597246826
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/847	57/9376	1.3594316369436	SCP2/HACD1/ACADVL/ECHS1/HADHB/ACAA2/HSD17B4	0.857723598396174
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/847	178/9376	1.18159266678163	SFRP4/BAMBI/MYC/DKK1/CACYBP/SIAH1/SERPINF1/RYK/RSPO3/CTNNB1/PRICKLE2/CXXC4/WNT6/SKP1/CCND2/CBY1/LZTS2/PLCB3/FZD2	0.770796779091847
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/847	38/9376	1.45653389672528	UAP1/GNPDA2/GNPDA1/PGM2/UXS1	0.888620193633918
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/847	29/9376	1.52684932622237	WTIP/FRMD6/MOB1A/TEAD3	0.895421654029963
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/847	169/9376	1.1790167874084	ATG5/AKT1/DDIT4/RRAGA/WDR41/EIF2AK3/PTEN/RHEB/TANK/SUPT20H/GABARAPL2/ERN1/WIPI1/NRBF2/RRAS/TBK1/ATG101/ATG4C	0.740041928146915
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/847	20/9376	1.66044864226682	UAP1/TGDS/CMAS	0.931723885509264
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/847	88/9376	1.25791563808093	F3/C7/PLAU/CFHR1/CFD/PROCR/BDKRB1/SERPINB2/SERPINE1/CFI	0.76601309539026
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/847	30/9376	1.47595434868162	GGH/IKBKG/ABCC5/ATIC	0.82279439470146
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/847	110/9376	1.20759901255769	IFNGR1/IFNGR2/AKT1/LDHB/CUL2/ELOC/CDKN1B/LDHA/EIF4E/PFKM/TIMP1/SERPINE1	0.690166323647536
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/847	90/9376	1.22996195723468	SOD2/ATG5/CAT/AKT1/RHEB/ADIPOR1/EIF4E/ATG101/CREB5/ADCY3	0.690782294403639
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/847	21/9376	1.58137965930174	ALDH3A2/PANK2/ALDH2	0.840477072343783
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/847	12/9376	1.84494293585203	NQO1/COQ2	0.922923248553218
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/847	70/9376	1.26510372744139	AKT1/CUL2/CDC42/RAP1B/FH/ELOC/PRCC/PAK3	0.701554825470421
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/847	205/9376	1.13396492642612	GTF2A2/CHEK1/GTF2B/NFKBIA/TBPL1/IRF7/CDC42/VDAC3/RANBP1/GSN/CDKN1B/HLA-F/CCND2/HDAC3/IKBKG/CDK4/YWHAQ/CREB5/GTF2H1/CASP8/CASP3	0.611136158375521
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/847	333/9376	1.0969930969931	FAS/LAMA2/AKT1/TBPL1/ATP6V0E1/CDC42/TNFRSF1A/ISG15/ATP6V1G1/PTEN/CTNNB1/RHEB/COL4A1/HES4/COL1A2/ITGB5/PARD6G/CDKN1B/MX1/HLA-F/WNT6/CCND2/OASL/COL4A5/IKBKG/TBK1/FADD/CDK4/CREB5/CASP8/FZD2/CASP3/GNAS	0.567917124302359
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/847	154/9376	1.15009429767399	AK6/PTS/NQO1/COQ2/GGH/NME7/MOCS2/ALDH3A2/CMPK1/PANK2/HMBS/DLD/RFK/ALDH2/CMPK2/HSD17B6	0.591820876220312
NA	NA	hsa04518	Integrin signaling	16/847	154/9376	1.15009429767399	ACTG1/VCAM1/LAMA2/AKT1/ITGAE/CDC42/PDGFRA/CTNNB1/VEGFB/COL4A1/COL1A2/ITGB5/VEGFC/ACTB/CCND2/COL4A5	0.591820876220312
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/847	22/9376	1.50949876569711	ALDH3A2/CARNMT1/ALDH2	0.753935303692373
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/847	144/9376	1.15308933490752	MYC/ID3/FGF2/LEFTY2/AKT1/ID4/CTNNB1/KLF4/WNT6/POU5F1/ID2/HESX1/ID1/FZD2/TBX3	0.583386762714706
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/847	32/9376	1.38370720188902	TNFRSF1A/FADD/CASP8/CASP3	0.68515181271694
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/847	52/9376	1.2772681863591	VDAC3/VDAC1/SOAT2/VDAC2/STARD3NL/VAPA	0.631798902585902
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/847	63/9376	1.22996195723468	GADD45A/BMP2/CTNNB1/WNT6/FZD2/GADD45B/HHIP	0.577111536182075
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/847	115/9376	1.15509470766388	MMP16/JUND/NACA/STK39/GNAI1/WNK2/PDE4B/CYP27B1/PLCB3/CREB5/ADCY3/GNAS	0.527345498016553
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/847	23/9376	1.44386838457985	IDI1/NUS1/ZMPSTE24	0.671615869753689
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/847	33/9376	1.34177668061966	ACO1/GOT1/IDH3A/DLD	0.619775649591558
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/847	33/9376	1.34177668061966	SEC22B/BET1/VAMP3/STX11	0.619775649591558
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/847	168/9376	1.12014392533873	MYC/IL15RA/IFNGR1/IFNGR2/AKT1/CSF3/IL13RA2/SOCS2/AOX1/PDGFRA/SOCS1/STAM/SOCS3/CCND2/IL15/CTF1/STAM2	0.495167450406096
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/847	105/9376	1.15967841682127	ACTG1/CACNA2D1/LAMA2/SGCB/ITGB5/ACTB/CACNA2D3/SNTB1/TPM4/ADCY3/GNAS	0.518508479623025
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/847	243/9376	1.09329951754194	HSPA8/LSM8/HSPA1A/HSPA1B/SNRNP40/SRSF9/LSM6/SNRPA1/EIF4A3/LSM5/SF3B6/PPIL1/PLRG1/SRSF7/SNRPF/SRSF1/MAGOH/MAGOHB/PPIH/ALYREF/PHF5A/SNRPB2/LSM2/THOC3	0.46435924041912
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/847	116/9376	1.14513699466678	ACTG1/CLDN10/MYL12B/VCAM1/CLDN23/MMP2/CDC42/RAP1B/MYL12A/CTNNB1/GNAI1/ACTB	0.495655481439494
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/847	106/9376	1.14873805439843	PLAU/AR/AKT1/NFKBIA/PDGFRA/PTEN/CTNNB1/CDKN1B/IKBKG/FOLH1/CREB5	0.485303527457858
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/847	44/9376	1.25791563808093	DYNLL1/DCTN6/CREB5/ADCY3/GNAS	0.540374609446614
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/847	170/9376	1.10696576151122	TUBA3D/ACTG1/CLDN10/MYL12B/ARPC1A/CLDN23/ARPC3/CDC42/MYL12A/PARD6G/ACTB/YBX3/ACTR3/HSPA4/TUBA1A/CDK4/RAB13	0.443518815687799
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/847	181/9376	1.10084992857469	CEBPB/RIPK2/IFNGR1/IFNGR2/AKT1/TNFRSF1A/BCL10/NFYB/CALM2/LBP/HSPD1/HLA-DOB/HSPA9/CYP27B1/FADD/CASP8/CASP3/IL1A	0.431735043938023
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/847	107/9376	1.13800218473116	PPP4C/AKT1/LDHB/PGAM1/PHKG1/CALM2/LDHA/PFKM/PLCB3/CREB5/GNAS	0.452417812720268
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/847	86/9376	1.15845254111639	ACTG1/CACNA2D1/LAMA2/SGCB/CTNNB1/ITGB5/ACTB/CACNA2D3/SNTB1	0.465177674430115
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/847	139/9376	1.11492954396813	HSPA8/HSPA1A/HSPA1B/AKT1/KRT10/KRT23/MMP2/CALM2/GNAI1/ESR2/PLCB3/CREB5/ADCY3/GNAS	0.430181666765566
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/847	76/9376	1.16522711738023	GADD45A/AKT1/PDGFRA/PTEN/CALM2/CDK4/GADD45B/CAMK1	0.455748170625979
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/847	77/9376	1.15009429767399	MYC/GADD45A/AKT1/NFKBIA/CDKN1B/IKBKG/CDK4/GADD45B	0.416744347399886
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/847	56/9376	1.1860347444763	GAS1/EFCAB7/CUL3/CCND2/MOSMO/HHIP	0.440005804399265
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/847	15/9376	1.47595434868162	ST6GALNAC4/SLC33A1	0.58133717023394
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/847	15/9376	1.47595434868162	NTPCR/ACP1	0.58133717023394
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/847	99/9376	1.11814723384971	PPP1CB/HTR2B/CALM2/PPP1CC/BDKRB1/IL1R1/NGF/PLCB3/ADCY3/GNAS	0.372405137141511
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/847	78/9376	1.13534949898586	CXCL8/CASP1/CALM2/GNAI1/CFL2/LY96/CASP3/IL1A	0.37825743138858
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/847	36/9376	1.22996195723468	C1GALT1C1/C1GALT1C1L/C1GALT1/ST6GALNAC4	0.435624297164368
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/847	89/9376	1.11940357905629	TUBA3D/PDGFRA/HTR2B/GNAI1/TUBA1A/PLCB3/ADCY3/MAPK7/GNAS	0.356658773232414
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/847	16/9376	1.38370720188902	GLA/A4GALT	0.484061234187164
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/847	166/9376	1.06695495085418	RGS2/AKT1/PPP1CB/VDAC3/ADRA2C/SLC25A5/CALM2/GNAI1/PPP1CC/PPIF/VDAC1/VDAC2/EDNRB/PLCB3/CREB5/ADCY3	0.274274360218776
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/847	59/9376	1.12572789306225	MYC/GADD45A/AKT1/PTEN/CTNNB1/GADD45B	0.305279668887635
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/847	27/9376	1.22996195723468	SCP2/HACD1/HSD17B4	0.377080074899194
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/847	168/9376	1.05425310620116	FAS/IFNGR1/PPID/IFNGR2/VDAC3/TNFRSF1A/CASP1/SLC25A5/PPIA/VDAC1/CHMP5/VDAC2/CAPN2/FADD/CASP8/IL1A	0.223601586168405
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/847	38/9376	1.16522711738023	TAP1/IKBKG/TAP2/ADA	0.321606246750046
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/847	103/9376	1.07472404030215	ACE2/COL21A1/MME/SLC36A4/CPB1/SLC3A2/COL3A1/COL4A1/COL1A2/COL4A5	0.240296317090229
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/847	49/9376	1.12955689950124	C1GALT1C1/C1GALT1C1L/C1GALT1/POGLUT1/B4GALT3	0.286527218549897
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/847	39/9376	1.13534949898586	MTHFS/GCSH/ATIC/DLD	0.266909211794119
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/847	138/9376	1.04279383330767	ACTG1/ARPC1A/CXCL8/AKT1/ARPC3/NFKBIA/CDC42/CASP1/ACTB/ACTR3/IKBKG/TBK1/WASL	0.159591604504932
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/847	117/9376	1.04073704073704	ACTG1/MORF4L2/ACTB/MEAF6/ACTL6A/MBD2/DPF1/YEATS4/SMARCE1/MTA1/ACTR6	0.139726458735237
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/847	95/9376	1.0487044056422	CXCL1/CXCL8/ATP6V0E1/CTSK/ATP6V1G1/CXCL2/HLA-DOB/IL15/IL1A	0.150352602668679
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/847	73/9376	1.06147401788747	GADD45A/FGF2/AKT1/PDGFRA/PTEN/CDK4/GADD45B	0.166157444791025
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/847	250/9376	1.01840850059032	ARL8A/LAPTM4A/ATP6V0E1/SLC36A4/BLOC1S2/VPS29/OSTM1/AP3S1/RRAGA/CTSK/GLA/ATP6V1G1/SNAPIN/AP1S1/LAPTM4B/CLTA/LAMTOR3/M6PR/LAMTOR1/IDUA/CLN5/OSBP/ARL8B	0.0929664985220284
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/847	63/9376	1.05425310620116	PTGES3/CYP2B6/GGT5/CBR1/PTGR1/PLA2G2A	0.136153361359882
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/847	41/9376	1.07996659659631	MYC/CXCL8/MMP2/CDK4	0.161704336253776
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/847	97/9376	1.02708163439185	GNG4/RASD1/GNG5/CALM2/GNAI1/GNB2/PLCB3/ADCY3/GNAS	0.0844867174095523
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/847	75/9376	1.03316804407713	PGAM1/RPE/ACO1/PFKM/GOT1/TKT/IDH3A	0.0908790874655801
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/847	19/9376	1.16522711738023	IDUA/HPSE	0.227178955232122
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/847	19/9376	1.16522711738023	GCSH/DLD	0.227178955232122
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/847	142/9376	1.01341935912999	JUNB/IFNGR1/IFNGR2/AKT1/JUND/NFKBIA/TNFRSF1A/CTSK/SOCS1/SOCS3/IL1R1/IKBKG/IL1A	0.0507760951242276
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/847	254/9376	1.00237057144716	AVPR1A/FGF2/VDAC3/PDGFRA/SLC25A5/HTR2B/PHKG1/VEGFB/CALM2/MCU/VEGFC/PPIF/VDAC1/BDKRB1/VDAC2/NGF/TACR1/EDNRB/PLCB3/ORAI3/ADCY3/GNAS/CAMK1	0.0120698857625732
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/847	109/9376	1.01556491881763	AKT1/PPP1CB/NFKBIA/SLC27A3/TNFRSF1A/SOCS3/PTEN/PPP1CC/NR1H2/CREB5	0.0515073033938005
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/847	154/9376	1.00633251046474	ACTG1/CACNA2D1/RGS2/PPP1CB/CALM2/GNAI1/PPP1CC/ACTB/CACNA2D3/PLCB3/ADCY3/MAPK7/GNAS/CAMK1	0.0249690491244241
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/847	87/9376	1.01789955081491	CACNA2D1/COX7A2L/UQCRH/UQCRFS1/COX8A/CACNA2D3/TPM4/COX6C	0.052856154545067
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/847	76/9376	1.0195737277077	ACTG1/CALM2/GNAI1/ACTB/PLCB3/ADCY3/GNAS	0.0539904752715997
NA	NA	hsa04981	Folate transport and metabolism	3/847	31/9376	1.07125718855924	MTHFS/ABCC5/FOLH1	0.125227053927098
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/847	99/9376	1.00633251046474	ACTG1/CACNA2D1/LAMA2/SGCB/ITGB5/ACTB/CACNA2D3/SNTB1/TPM4	0.0199603439812399
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/847	54/9376	1.02496829769557	FANCL/RPA3/PALB2/FANCM/FANCF	0.0579841840973364
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/847	133/9376	0.998766100611624	SOD2/GADD45A/CAT/AKT1/PTEN/KLF2/CDKN1B/GABARAPL2/CCND2/CCNG2/HOMER3/GADD45B	-0.00451624380742848
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/847	133/9376	0.998766100611624	GNG4/COMT/AKT1/PPP1CB/GNG5/CALM2/GNAI1/PPP1CC/GNB2/PLCB3/CREB5/GNAS	-0.00451624380742848
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/847	77/9376	1.00633251046474	GADD45A/AKT1/CDC42/IKBKG/RALB/CDK4/GADD45B	0.017582532993784
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/847	66/9376	1.00633251046474	COMT/CYP7B1/HSD11B1/HSD17B7/SRD5A3/HSD17B6	0.0162686430193316
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/847	32/9376	1.03778040141677	GLA/PGM2/PFKM	0.0674611015598217
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/847	78/9376	0.99343081161263	MARCKSL1/IFNGR1/IFNGR2/NFKBIA/EEF1A1/HLA-DOB/IL1A	-0.0183587257014811
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/847	101/9376	0.986405134019895	CTNNB1/CALM2/GNAI1/WNT6/EDNRB/PLCB3/FZD2/ADCY3/GNAS	-0.0432869458173868
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/847	158/9376	0.980855738047913	AKT1/DDIT4/TNFRSF1A/SLC3A2/RRAGA/ATP6V1G1/PTEN/CAB39/RHEB/WNT6/LAMTOR3/EIF4E/LAMTOR1/FZD2	-0.07647634185603
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/847	102/9376	0.976734495451073	RAB27B/CPB1/RAP1B/BST1/PLCB3/PLA2G2A/TRPC1/ADCY3/GNAS	-0.074448731362047
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/847	45/9376	0.983969565787748	FAS/HLA-F/HLA-DOB/IL1A	-0.0339676681894378
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/847	217/9376	0.969232694410742	MYC/MGST1/FGF2/AR/AKT1/MGST3/PTGES3/GSTO1/GNAI1/CYP2B6/KLF4/GSTM3/ESR2/GSTT2B/MGST2/GSTA4/CREB5/ADCY3/GNAS	-0.144501910366478
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/847	115/9376	0.962578923053231	GNG4/DUSP1/GNG5/HTR2B/GNAI1/GNB2/PLCB3/TRPC1/CASP3/GNAS	-0.127237329732597
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/847	10/9376	1.10696576151122	SQOR	0.1066463501446
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/847	70/9376	0.948827795581042	AKT1/NFKBIA/TNFRSF1A/SOCS3/ADIPOR1/IKBKG	-0.13541909533511
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/847	105/9376	0.948827795581042	SIAH1/MTX2/EIF2AK3/GABARAPL2/CCZ1/AMFR/RRAS/TBK1/TOMM40	-0.166166614376761
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/847	163/9376	0.95076813872129	MYC/FAS/CXCL8/AKT1/NFKBIA/IRF7/VDAC3/IKBKG/TBK1/FADD/YWHAQ/CREB5/CASP8/CASP3	-0.19981027060139
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/847	71/9376	0.935464023812295	AKT1/SOCS2/SOCS1/SOCS3/CCND2/ESR2	-0.172008993842082
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/847	233/9376	0.950185203013919	VIM/ACTG1/DCN/LAMA2/CAPZA2/CSRP1/FBLN2/COL3A1/SGCB/COL4A1/COL1A2/ITGB5/PDLIM1/ACTB/SYNPO2/SDC4/COL4A5/SNTB1/TPM4/TMEM43	-0.242644388193154
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/847	83/9376	0.933585581997411	PHC2/UBE2D1/PHF1/SKP1/USP45/TFDP1/SCML2	-0.19151453264172
NA	NA	hsa03272	Virion - Hepatitis viruses	4/847	48/9376	0.922471467926013	CLDN10/CLDN23/TSG101/PDCD6IP	-0.169693886821083
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/847	155/9376	0.928422896751342	RASD1/RAP1B/FH/CTNNB1/GNAI1/CDKN1B/WNT6/PLCB3/CDK4/CREB5/FZD2/ADCY3/GNAS	-0.283158264988781
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/847	61/9376	0.907348984845259	MT1X/MT2A/HEPH/MT1E/CYBRD1	-0.228771519192534
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/847	37/9376	0.897539806630716	VCAM1/FAS/PLCB3	-0.196781438799773
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	20/847	238/9376	0.930223329001022	GNG4/FGF2/AKT1/CDC42/RAP1B/PDGFRA/GNG5/NTF3/VEGFB/CALM2/VEGFC/GNB2/IKBKG/RALB/NGF/RRAS/PAK3/TBK1/PLA2G2A/RASA3	-0.343598637895463
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/847	98/9376	0.903645519600993	MARCKSL1/ARPC1A/AKT1/ARPC3/CDC42/GSN/CFL2/ACTR3	-0.302159361212466
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/847	122/9376	0.907348984845259	ACTG1/MYC/MED30/AKT1/CTNNB1/RHEB/ACTB/PFKM/HDAC3/PLCB3	-0.324596353038123
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/847	122/9376	0.907348984845259	JUNB/AKT1/SOCS2/SOCS1/SOCS3/GNAI1/PLCB3/CREB5/ADCY3/GNAS	-0.324596353038123
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/847	193/9376	0.91769182301448	GNG4/CXCL1/CXCL8/AKT1/NFKBIA/CDC42/RAP1B/GNG5/GNAI1/CXCL9/CXCL2/GNB2/IKBKG/PLCB3/ADCY3/CCL21	-0.364089061375585
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/847	87/9376	0.890662106963047	MYC/GADD45A/AKT1/CTNNB1/RALB/GADD45B/CASP3	-0.322867351910239
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/847	63/9376	0.878544255167632	ECHS1/ALDH3A2/DLD/ALDH2/PRDM6	-0.304804813462312
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/847	26/9376	0.851512124239397	FOLH1/LMBRD1	-0.238918703334732
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/847	39/9376	0.851512124239397	FAS/HLA-F/HLA-DOB	-0.292818090773911
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/847	125/9376	0.885572609208973	CERS2/ORMDL1/AKT1/SPTSSA/TNFRSF1A/PTEN/S1PR3/GNAI1/PLCB3/CERS4	-0.405853174539659
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/847	89/9376	0.870647228154889	GNG4/GAD1/GNG5/GNAI1/GABARAPL2/GNB2/ADCY3	-0.386377035639292
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/847	13/9376	0.851512124239397	LIG4	-0.168823711969111
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/847	65/9376	0.851512124239397	AKT1/TRPC4/ESR2/PLCB3/TRPC1	-0.3785539616373
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/847	138/9376	0.882364012798795	AKT1/PPP1CB/SOCS2/SOCS1/SOCS3/PHKG1/RHEB/CALM2/PPP1CC/RHOQ/EIF4E	-0.438701431815837
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/847	27/9376	0.819974638156456	GAD1/ECHS1	-0.295196552264686
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/847	91/9376	0.851512124239397	GNG4/GNG5/GNAI1/GNB2/PDE4B/ADCY3/GNAS	-0.448537773207417
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/847	41/9376	0.809974947447231	PGAM1/GCSH/DLD	-0.384258881864841
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/847	140/9376	0.869758812615956	GNG4/AKT1/GNG5/CALM2/GNAI1/KLF2/GNB2/RRAS/PLCB3/SERPINE1/ADCY3	-0.489270114206007
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/847	116/9376	0.858852746000081	GNG4/GNG5/GNAI1/GNB2/PLCB3/HOMER3/TRPC1/ADCY3/GNAS	-0.482030169467244
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/847	28/9376	0.790689829650869	A4GALT/B4GALT3	-0.3495330777732
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/847	28/9376	0.790689829650869	ATP6V0E1/ATP6V1G1	-0.3495330777732
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/847	14/9376	0.790689829650869	B4GALT3	-0.246972340096596
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/847	67/9376	0.826093851874042	PPP1CB/RAP1B/CALM2/PPP1CC/PLCB3	-0.450172652243815
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/847	80/9376	0.830224321133412	FGF2/AKT1/PDGFRA/GAS6/PTEN/EIF4E	-0.480563406919128
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/847	105/9376	0.843402484960927	AKT1/NFKBIA/CASP1/BCL10/CALM2/IKBKG/RRAS/CASP8	-0.508504161376654
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/847	154/9376	0.862570723255493	CACNA2D1/AKT1/PPP1CB/CALM2/GNAI1/PPP1CC/CACNA2D3/PLCB3/TPM4/CREB5/ADCY3/GNAS	-0.541882777971464
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/847	93/9376	0.833200035546077	MMP2/CDC42/CALM2/PLCB3/ADCY3/MAPK7/GNAS	-0.509414777264316
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/847	69/9376	0.802149102544359	PPP1CB/CALM2/PPP1CC/CREB5/GNAS	-0.519799669639109
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/847	120/9376	0.830224321133412	RIPK2/AKT1/NFKBIA/CDC42/RAP1B/NTF3/CALM2/NGF/MAPK7	-0.589837950590134
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/847	16/9376	0.69185360094451	GOT1	-0.388738406531846
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/847	31/9376	0.714171459039494	ALDH3A2/ALDH2	-0.502313757200892
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/847	122/9376	0.816614086360733	MAP3K8/AKT1/NFKBIA/CDC42/BCL10/NCK1/IKBKG/PAK3/CDK4	-0.642479725305246
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/847	184/9376	0.842256557671577	MYL12B/TRPC4/CDC42/MYL12A/RYK/GNAI1/PARD6G/NCK1/CFL2/SEMA6D/RRAS/NRP1/PAK3/TRPC1	-0.680978661885672
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/847	59/9376	0.750485262041502	AKT1/GNAI1/ADCY3/GNAS	-0.60584628224732
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/847	148/9376	0.822744822744823	MYC/GADD45A/FGF2/AKT1/PTEN/CTNNB1/WNT6/ESR2/CDK4/FZD2/GADD45B	-0.684942760584718
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/847	98/9376	0.790689829650869	CALM2/PLCB3/CREB5/PRKD3/ADCY3/GNAS/CAMK1	-0.656378687385019
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/847	46/9376	0.721934192289924	FXN/HEPH/HMBS	-0.595749887992821
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/847	99/9376	0.782703063694799	AKT1/MMP2/CDKN1B/ESR2/CDK4/ADCY3/GNAS	-0.684929242339303
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/847	47/9376	0.706573890326308	SOCS2/SOCS1/SOCS3	-0.635489565878864
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/847	100/9376	0.774876033057851	ACKR3/CXCL1/CXCL8/TNFRSF1A/CXCL9/CXCL2/CCL21	-0.713213654394513
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/847	75/9376	0.737977174340811	HSPA5/PLCB3/CREB5/ADCY3/GNAS	-0.717931851383285
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/847	34/9376	0.651156330300715	NFIL3/SKP1	-0.642138426716831
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/847	89/9376	0.746269052704191	LAMA2/COL4A1/COL1A2/ITGB5/SDC4/COL4A5	-0.757894940075145
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/847	115/9376	0.770063138442585	GNG4/AKT1/GNG5/GNAI1/GNB2/PLCB3/CREB5/ADCY3	-0.781820157481747
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/847	49/9376	0.677734139700744	GNAI1/CREB5/GNAS	-0.712721135968918
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/847	90/9376	0.737977174340811	IFNGR1/IFNGR2/AKT1/NFKBIA/PTEN/IKBKG	-0.787089877262881
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/847	35/9376	0.632551863720695	PFKM/TIGAR	-0.686296321718152
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/847	104/9376	0.745073108709472	CHPT1/ETNK1/SELENOI/PGS1/CRLS1/PLPP5/PLA2G2A	-0.823803996160615
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/847	50/9376	0.66417945690673	IL15RA/HLA-DOB/IL15	-0.750279088987302
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/847	50/9376	0.66417945690673	VCAM1/CXCL8/CSF3	-0.750279088987302
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/847	194/9376	0.798841271193661	TUBA3D/ACTG1/DYNLL1/MYL12B/ACTR10/DYNLT3/CAPZA2/MYL12A/DYNLT1/DCTN6/ACTB/TUBA1A/TUBE1/TPM4	-0.892173643896801
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/847	36/9376	0.614980978617342	PGM2/GBE1	-0.729353857488545
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/847	157/9376	0.775581106791298	CEBPB/ODC1/CASP1/GAS6/CALR/DUSP5/UQCRFS1/GULP1/ITGB5/NR1H2/CASP3	-0.893605063638709
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/847	65/9376	0.681209699391518	GLA/ALDH3A2/PLPP5/ALDH2	-0.812721783571407
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/847	65/9376	0.681209699391518	PLCB3/CREB5/ADCY3/GNAS	-0.812721783571407
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/847	51/9376	0.651156330300715	CHPT1/SELENOI/PLA2G2A	-0.787172294966067
NA	NA	hsa04519	Cadherin signaling	31/847	404/9376	0.849404420961577	VIM/ACTG1/PCDH18/ARPC1A/PCDHGA12/PCDHB15/ARPC3/KRT10/PPP1CB/KRT23/NFKBIA/CDC42/PDGFRA/RYK/LHFPL3/CTNNB1/PPP1CC/PRICKLE2/ACTB/WTIP/WNT6/BRK1/ACTR3/MOB1A/IKBKG/RRAS/YWHAQ/TEAD3/FZD2/PCDHGB7/PCDHGA9	-0.975071715865476
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/847	66/9376	0.670888340309828	IFNGR1/IFNGR2/HLA-DOB/IL1A	-0.845509870818248
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/847	52/9376	0.638634093179548	HSD17B7/ADCY3/GNAS	-0.82342870402532
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/847	134/9376	0.743484466686638	AVPR1A/PPP1CB/CALCRL/CALM2/PPP1CC/PLCB3/PLA2G2A/ADCY3/GNAS	-0.942456626231704
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/847	53/9376	0.626584393308236	CLTA/PLCB3/GNAS	-0.85907453148064
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/847	149/9376	0.742930041282695	AVPR1A/CXCL8/AKT1/PDGFRA/RHEB/RALB/RRAS/PLCB3/ADCY3/GNAS	-0.996764329647708
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/847	54/9376	0.614980978617342	FAS/HLA-F/HLA-DOB	-0.894134397507965
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/847	362/9376	0.825637446431018	MYC/GNG4/LAMA2/FGF2/AKT1/CSF3/DDIT4/PDGFRA/GNG5/NTF3/PTEN/RHEB/VEGFB/COL4A1/COL1A2/ITGB5/VEGFC/CDKN1B/CCND2/EIF4E/COL4A5/GNB2/IKBKG/NGF/CDK4/YWHAQ/CREB5	-1.06617136772278
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/847	201/9376	0.771020928415772	MYC/CEBPB/GADD45A/HOXA10/PLAU/CXCL8/HOXA11/PRCC/CDKN1B/CCND2/CCNT2/DDIT3/ID2/GADD45B	-1.03411554975347
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/847	69/9376	0.641719282035488	CALM2/GNAI1/PLCB3/GNAS	-0.941285590467292
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/847	55/9376	0.603799506278845	CERS2/GLA/CERS4	-0.928631453134465
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/847	138/9376	0.721934192289924	AR/CDC26/PPP1CB/CALM2/PPP1CC/SKP1/ESPL1/YWHAQ/ADCY3	-1.03699446813661
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/847	23/9376	0.481289461526616	GOT1	-0.784859299625422
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/847	23/9376	0.481289461526616	B4GALT3	-0.784859299625422
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/847	23/9376	0.481289461526616	RPA3	-0.784859299625422
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/847	23/9376	0.481289461526616	MDH1	-0.784859299625422
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/847	41/9376	0.539983298298154	RPA3/PALB2	-0.930222099983458
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/847	24/9376	0.461235733963007	B4GALT7	-0.832780296046407
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/847	86/9376	0.64358474506466	MYC/AKT1/CDKN1B/NCK1/PAK3	-1.04634749467637
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/847	73/9376	0.606556581649981	GADD45A/AKT1/CDK4/GADD45B	-1.06343387514635
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/847	183/9376	0.725879187876207	AK6/NOP10/RAN/RPP30/RPP40/NXT1/RIOK2/POP7/EFL1/RIOK1/WDR3/WDR36	-1.1800956534803
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/847	298/9376	0.78007654334683	ACKR3/CXCL1/TNFRSF12A/FAS/IL15RA/IFNGR1/IFNGR2/CXCL8/CSF3/IL13RA2/TNFRSF1A/TNFSF12/BMP2/IL1R1/CXCL9/CXCL2/IL15/CTF1/NGF/CCL21/IL1A	-1.21580207965751
NA	NA	hsa04517	IgSF CAM signaling	21/847	299/9376	0.777467591696841	TUBA3D/ACTG1/DYNLL1/MYL12B/ARPC1A/AKT1/ARPC3/CDC42/RAP1B/MYL12A/PMP22/CTNNB1/PARD6G/ACTB/NCK1/ACTR3/TUBA1A/NRP1/PAK3/WASL/CASK	-1.23235542316051
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/847	26/9376	0.425756062119699	PLA2G2A	-0.923965113874929
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/847	60/9376	0.553482880755608	GNAI1/PLCB3/GNAS	-1.0933955086372
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/847	78/9376	0.567674749492931	MINPP1/PTEN/PLCB3/OCRL	-1.20820719697166
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/847	93/9376	0.595142882532912	IFNGR1/IFNGR2/NFKBIA/HLA-DOB/IKBKG	-1.23645229178296
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/847	93/9376	0.595142882532912	BST1/CALM2/PLCB3/ADCY3/GNAS	-1.23645229178296
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/847	122/9376	0.635144289391681	AKT1/CAB39/RHEB/ADIPOR1/PFKM/CREB5/ELAVL1	-1.27824646983949
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/847	150/9376	0.66417945690673	MYC/GADD45A/FGF2/AKT1/CTNNB1/CDKN1B/WNT6/FZD2/GADD45B	-1.30654523437347
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/847	29/9376	0.381712331555592	CALM2	-1.05082827136644
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/847	109/9376	0.609338951290578	IFNGR1/IFNGR2/NFKBIA/IL1R1/HLA-DOB/IKBKG	-1.29277238100502
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/847	48/9376	0.461235733963007	AKT1/PLCB3	-1.17924330486326
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/847	30/9376	0.368988587170405	PLA2G2A	-1.09084548740228
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/847	195/9376	0.681209699391518	ACTG1/AKT1/VDAC3/CASP1/SLC25A5/HAT1/PPIF/VDAC1/VDAC2/ACTB/HDAC3/PLCB3	-1.41760650496614
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/847	98/9376	0.564778449750621	PIP4P2/PTEN/CALM2/PLCB3/OCRL	-1.36481733973013
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/847	99/9376	0.559073616924857	KRT10/KRT23/CFD/HLA-DOB/CFI	-1.38981882865985
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/847	99/9376	0.559073616924857	CHPT1/AKT1/PDGFRA/RHEB/SLC22A3	-1.38981882865985
Human Diseases	Immune disease	hsa05310	Asthma	1/847	32/9376	0.345926800472255	HLA-DOB	-1.16792032075442
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/847	68/9376	0.488367247725537	MYC/AKT1/IKBKG	-1.33432890281356
NA	NA	hsa04082	Neuroactive ligand signaling	12/847	199/9376	0.667517042117316	GNG4/P2RY14/ADRA2C/GNG5/HTR2B/GNAI1/OGFRL1/GNB2/TACR1/PLCB3/ADCY3/GNAS	-1.49390798310089
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/847	100/9376	0.553482880755608	CSF3/MME/IL1R1/HLA-DOB/IL1A	-1.41460774119994
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/847	86/9376	0.514867796051728	PLCB3/CREB5/ADCY3/GNAS	-1.42422878695299
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/847	191/9376	0.637519548514313	GNG4/PPP1CB/GNG5/CALM2/HAT1/GNAI1/PPP1CC/GNB2/HDAC3/CREB5/GNAS	-1.59492394977295
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/847	36/9376	0.307490489308671	RPE	-1.311842934815
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/847	36/9376	0.307490489308671	RPA3	-1.311842934815
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/847	91/9376	0.486578356708227	AKT1/NFKBIA/BCL10/IKBKG	-1.55089430311377
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/847	76/9376	0.436960169017585	PLIN2/SCP2/DBI	-1.55304030614592
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/847	226/9376	0.636750216798487	AKT1/PPP1CB/NFKBIA/RAP1B/CALM2/GNAI1/PPP1CC/PDE4B/RRAS/CREB5/HHIP/ADCY3/GNAS	-1.74191645793907
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/847	60/9376	0.368988587170405	AKT1/CDC42	-1.54517042001489
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/847	79/9376	0.420366744877677	ATP6V0E1/ATP6V1G1/CLTA	-1.63032320656256
NA	NA	hsa04081	Hormone signaling	12/847	219/9376	0.606556581649981	AVPR1A/GNG4/ADRA2C/GNG5/GNAI1/ADIPOR1/HEPH/ESR2/GNB2/PLCB3/ADCY3/GNAS	-1.85654731186678
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/847	43/9376	0.257433898025864	PLA2G2A	-1.53793153057333
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/847	44/9376	0.251583127616185	MPG	-1.56805332986735
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/847	110/9376	0.402533004185897	CDC26/AKT1/GNAI1/ADCY3	-1.98628883115313
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/847	160/9376	0.415112160566706	CLDN10/VCAM1/CLDN23/HLA-F/SDC4/HLA-DOB	-2.35147105023878
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/847	90/9376	0.245992391446937	ADCY3/GNAS	-2.2649620489294
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/847	133/9376	0.332922033537208	FAS/IFNGR1/IFNGR2/CASP3	-2.44159836976148
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/847	69/9376	0.160429820508872	AKT1	-2.20574335295184
NA	NA	hsa04382	Cornified envelope formation	8/847	217/9376	0.408097976593997	CLDN10/CLDN23/KRT10/KRT23/COL4A1/S100A16/COL4A5/KAZN	-2.77993056245438
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/847	323/9376	0.479799401274211	VIM/MYC/PLAU/MMP16/DDIT4/PDGFRA/SOCS1/UBE2I/PTEN/CDKN1B/CCND2/CCNG1/MAPK7/CASP3	-2.99815536867167
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/847	86/9376	0.128716949012932	PLCB3	-2.55787266378285
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/847	143/9376	0.154820386225345	C7/HLA-DOB	-3.2094003835669
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/847	370/9376	0.299179935543572	AVPR1A/P2RY14/CALCRL/ADRA2C/HTR2B/S1PR3/OGFRL1/BDKRB1/TACR1/EDNRB	-4.33430734731256
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/847	449/9376	0.0739620776065401	RGS2/CALM2/ADCY3	-6.33690886356925