category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/644	158/9376	2.85651387687711	CUL1/BUB1/TTK/CCNA2/RBL1/MAD2L1/MDM2/CCNB1/RB1/ANAPC1/CDK2/CCNB2/FBXO5/CCNH/ORC1/ESCO1/WAPL/CDCA5/CDC27/CDK6/KNL1/GADD45A/CDC6/CHEK1/CDC45/PLK1/TFDP1/DDX11/CDC16/ANAPC5/CDKN2A	6.39116602883757
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	32/644	174/9376	2.67751838366531	HSPA5/CUL1/HSPH1/HYOU1/CALR/DNAJB11/BAG2/MAPK9/SEC24D/PDIA4/HSPA8/DDIT3/FBXO6/HERPUD1/SYVN1/STT3B/PDIA6/EIF2S1/SAR1B/SEL1L/PREB/ERO1B/OSTC/HSP90AA1/UBE2J1/DERL3/UBXN2A/YOD1/UBQLN1/EDEM1/UGGT1/DERL1	6.0655823908351
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	26/644	142/9376	2.66573353162453	CUL1/SOCS1/UBE2W/SIAH1/MDM2/ITCH/SYVN1/CUL3/ANAPC1/UBA6/TRIP12/PPIL2/UBE2J1/CDC27/UBE2Q1/CUL2/PML/UBE2S/HERC1/BIRC2/FANCL/UBE2C/CDC16/ANAPC5/UBR5/TRAF6	5.43158366725782
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/644	133/9376	2.408256666511	KLRC1/KLRC2/SH2D1B/GZMB/KLRD1/CASP3/FCER1G/SYK/BID/KIR2DL3/KLRC3/NCR3/VAV3/PRF1/KIR2DL4/LAT2/PPP3CA/TYROBP/PPP3CC/MAPK1/NRAS/KLRK1	4.44194184270366
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/644	44/9376	3.63975155279503	GTF2H2/GTF2H2C/TAF9/MNAT1/GTF2B/CCNH/TBP/TAF12/TAF2/GTF2A2/TAF5L	4.76621616820685
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/644	75/9376	2.91180124223603	CASP3/BID/SIAH1/MDM2/CCNB1/CASP8/CDK2/CCNB2/SESN1/RRM2B/CDK6/GADD45A/CHEK1/PMAIP1/CDKN2A	4.51419439647413
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/644	157/9376	2.22558056731416	CCNA2/RBL1/PPID/NBN/RRAS2/MDM2/CCNB1/RB1/RAD50/KIR2DL4/CDK2/CCNB2/PPP3CA/LIN54/ITPR1/PPP3CC/CDK6/LIN9/GADD45A/IL6/CHEK1/MAPK1/NRAS/CDKN2A	4.20553733961673
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/644	187/9376	2.10210250107948	PSTPIP1/OAS2/IL18/CASP1/MAPK9/OAS1/TBK1/CARD16/CASP8/TAB3/ATG16L1/RIPK2/TP53BP1/ITPR1/HSP90AA1/TRAF5/DNM1L/IL6/CARD8/MAPK1/IRF7/TRPV2/OAS3/BIRC2/TAB2/MAP1LC3B/TRAF6	4.13409425273077
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/644	20/9376	5.09565217391304	LBR/HSD17B7/MSMO1/FDFT1/SC5D/SQLE/CYP51A1	4.97925841956759
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/644	63/9376	3.00423937691018	GTF2H2/POLR2M/GTF2H2C/MNAT1/RFC4/POLR2B/CCNH/POLR2D/RFC5/POLE2/RPA1/RPA2/ERCC5	4.33457749674154
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/644	137/9376	2.23167248492542	GZMB/CASP3/CASP10/MAPK9/CTSW/BCL2L11/BID/DDIT3/PRF1/CASP8/EIF2S1/LMNB1/ITPR1/GADD45A/MAPK1/PMAIP1/NRAS/PARP4/PARP2/BIRC2/TUBA1B	3.94379877667854
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	25/644	180/9376	2.02208419599724	OAS2/CASP3/CALR/SYK/SRSF6/PILRB/BST2/BID/OAS1/TBK1/NECTIN1/CASP8/EIF2S1/POU2F1/TRAF5/IL6/SRSF1/IRF7/ZC3HAV1/PML/SRSF8/OAS3/BIRC2/TAB2/TRAF6	3.76006326886958
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/644	30/9376	3.8824016563147	SDHD/DLD/SUCLA2/ACLY/SUCLG2/DLAT/IDH3A/FH	4.29411771931713
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/644	105/9376	2.35717243419107	FCER1G/CASP1/SYK/MAPK9/CYLD/RRAS2/MDM2/KSR1/CASP8/MALT1/ARHGEF12/PPP3CA/ITPR1/PPP3CC/IL6/MAPK1/NRAS	3.79785253202979
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/644	78/9376	2.61315496098105	EXOSC7/LSM5/C1D/LSM6/EXOSC8/EXOSC3/LSM1/CNOT7/EXOSC6/HSPD1/CNOT10/CNOT3/ZCCHC7/LSM8	3.88508322772811
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/644	108/9376	2.2916954221302	XPO1/NCBP1/NUP50/NUP54/XPO4/RANBP17/NXT1/IPO7/KPNA3/NUP93/CSE1L/MAGOHB/IPO11/NMD3/NUP58/THOC3/NDC1	3.66649159659173
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/644	56/9376	2.85980479148181	CASP3/IL18/CASP1/HSPA8/HBS1L/SEC22B/CASP8/SAR1B/CLK4/HSPD1/IL6	3.79074986302719
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/644	248/9376	1.76117010619114	SNX18/CASP3/IL18/PIK3CG/CASP1/MAPK9/ARF6/ARPC5L/CDC42/LEF1/CTNNB1/CASP8/TAB3/RAB5B/RIPK2/ARPC1B/KPNA3/HSP90AA1/ACTR3/CSE1L/IL6/CYTH4/MAPK1/ACTR10/FBXO22/BIRC2/TAB2/TUBA1B/PLEKHM1/TRAF6	3.29906943946729
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/644	205/9376	1.8465081048326	CASP3/GTF2H2/CCNA2/SYK/RBL1/PRKACB/GTF2H2C/MDM2/RB1/CDC42/DDX3X/CASP8/CDK2/GTF2B/RASA2/TBP/TRAF5/CDK6/KAT2A/CHEK1/MAPK1/IRF7/PMAIP1/NRAS/GTF2A2/CDKN2A	3.32790877422827
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/644	216/9376	1.81987577639752	HSPA5/CASP3/IL18/CASP1/MAPK9/BID/HSPA8/DDIT3/TBK1/VAV3/CDC42/CASP8/EIF2S1/CCL3/PPP3CA/ITPR1/POU2F1/HSP90AA1/PPP3CC/ARHGEF1/HSPD1/IL6/MAPK1/IRF7/NRAS/TAB2/TRAF6	3.31054047727975
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/644	14/9376	5.19964507542147	B3GNT7/B4GALT1/B3GNT2/B4GALT4/B4GALT3	4.27035515980783
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/644	36/9376	3.23533471359558	PRIM2/PRIM1/RFC4/RFC5/POLE2/DNA2/RPA1/RPA2	3.64915308842928
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/644	44/9376	2.97797854319593	NEIL3/RFC4/PARG/RFC5/LIG3/POLE2/PNKP/PARP4/PARP2	3.57134871384569
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	16/644	110/9376	2.11767363071711	BUB1/CCNA2/MAPK9/MAD2L1/PRKACB/CCNB1/ADCY7/ANAPC1/CDK2/CCNB2/HSP90AA1/CDC27/MAPK1/PLK1/CDC16/ANAPC5	3.20211487268887
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/644	72/9376	2.42650103519669	CASP10/MAPK9/CYLD/TBK1/RNF125/DDX3X/CASP8/AZI2/DHX58/IRF7/SIKE1/TRAF6	3.29970562321291
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	25/644	205/9376	1.77548856233904	OAS2/CASP3/CALR/CCNA2/SYK/MAPK9/BCL2L11/BID/OAS1/TBK1/MDM2/RB1/CASP8/PSMD6/POLK/CDK2/PSMD12/TRAF5/CDK6/GADD45A/IL6/IRF7/OAS3/TAB2/TRAF6	3.04870700727916
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/644	23/9376	3.79800162030786	RFC4/PMS2/RFC5/MLH1/RPA1/RPA2	3.64844766446152
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	39/644	368/9376	1.54293815825007	HSPA5/COX6A2/CASP3/HNRNPA2B1/CASP1/PSMA2/WDR41/BID/SDHD/DDIT3/NCBP1/TBK1/NDUFB5/NUP50/NUP54/PSMA6/RAB8A/NRBF2/PSMD6/EIF2S1/PSMD12/NDUFA8/PPP3CA/NXT1/NDUFA7/HNRNPA1/PPP3CC/HNRNPA3/SPG11/NUP93/UBQLN1/ACTR10/DERL1/DNAH14/NUP58/MAP1LC3B/NDUFV3/TUBA1B/NDC1	2.88557119708822
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/644	75/9376	2.32944099378882	TOP2B/CASP3/BID/GSTP1/MDM2/CASP8/ATP7A/MLH1/MAPK1/PMAIP1/BIRC2/CDKN2A	3.13911035939351
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/644	156/9376	1.86653925784361	OAS2/CASP3/BID/OAS1/MX1/TBK1/RB1/CTNNB1/CASP8/EIF2S1/CDK2/RSAD2/PPP2R2D/CDK6/PPP2R2A/MAPK1/IRF7/NRAS/OAS3/TRAF6	2.96385388706821
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/644	32/9376	3.18478260869565	CASP3/MAPK9/BCL2L11/BID/CASP8/PMAIP1/BIRC2	3.36192880881029
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/644	136/9376	1.92692729265619	OAS2/CASP3/MAPK9/BID/HSPA8/OAS1/MX1/TBK1/IL2RB/CASP8/EIF2S1/CDK2/CDK6/IL6/IRF7/OAS3/TAB2/TRAF6	2.95699674693213
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/644	169/9376	1.80910728067919	MAPK9/WDR41/PRKACB/STX17/RRAS2/TBK1/RAB8A/NRBF2/DAPK2/EIF2S1/STX7/ATG16L1/ITPR1/SUPT20H/MAPK1/ATG10/NRAS/EPG5/MAP1LC3B/PLEKHM1/TRAF6	2.88245209490673
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/644	41/9376	2.84078169974246	NBN/RAD50/BRCA2/RAD54B/BARD1/BLM/RPA1/RPA2	3.20781093636961
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/644	33/9376	3.08827404479578	STX17/STX18/SEC22B/STX7/BET1/GOSR2/STX6	3.26342017836375
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	18/644	138/9376	1.89900081015393	CUL1/BUB1/MAD2L1/PRKACB/CCNB1/ADCY7/ANAPC1/CDK2/CCNB2/FBXO5/PPP3CA/ITPR1/CDC27/PPP3CC/MAPK1/PLK1/CDC16/ANAPC5	2.88923159700353
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/644	138/9376	1.89900081015393	IL18/CASP1/MAPK9/ARF6/ARPC5L/TBK1/SKAP2/VAV3/CDC42/ARHGEF12/ARPC1B/ACTR3/ARHGEF1/IL6/MAPK1/TAB2/LIMK1/TRAF6	2.88923159700353
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/644	119/9376	1.95751344015867	CASP3/CASP10/MAPK9/JAG1/CYLD/ITCH/CASP8/TAB3/TRAF5/DNM1L/IL6/MAPK1/MAP3K8/BIRC2/ADAM17/TAB2	2.85466359017347
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/644	43/9376	2.70865231835909	ECI2/GCDH/ACSL3/ACADM/ACSL4/ACAT2/ALDH3A2/HADHB	3.04964300603824
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	28/644	253/9376	1.61127341467606	CUL1/IL18/CASP1/MAPK9/FNBP1L/PPID/UBE2V1/ARF6/ARPC5L/TBK1/MDM2/CDC42/TAB3/MALT1/ATG16L1/RIPK2/ARPC1B/ITPR1/TIFA/ACTR3/TRAF5/UBE2V2/CYTH4/MAPK1/TAB2/MAP1LC3B/GLMN/TRAF6	2.67669347048266
Genetic Information Processing	Translation	hsa03010	Ribosome	25/644	222/9376	1.63952772648425	MRPL18/MRPL39/MRPL19/MRPL45/MRPS31/RPS10/MRPL3/MRPS26/MRPL32/RPS21/RPL36A/RPL17/MRPS22/RPL22L1/RPS19/MRPS30/MRPL44/MRPS18C/MRPS7/MRPL9/MRPS35/MRPL11/MRPS11/RSL24D1/MRPL30	2.61879871674095
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/644	82/9376	2.13058627480685	KLRC1/HSPA5/KLRC2/KLRD1/CALR/KLRC4/HSPA8/KIR2DL3/KLRC3/KIR2DL4/HSP90AA1/RFX5	2.79242173270475
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/644	54/9376	2.42650103519669	POLK/PMS2/BRCA2/MLH1/BLM/UBE2T/RPA1/FANCL/RPA2	2.85486864077615
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/644	224/9376	1.62488908606921	CALR/CCNA2/XPO1/MAPK9/MAD2L1/PRKACB/ADCY7/RB1/IL2RB/ELK4/ANAPC1/CDK2/CCNB2/PPP3CA/TBP/CDC27/PPP3CC/KAT2A/IL6/CHEK1/MAPK1/NRAS/CDC16/ANAPC5/CDKN2A	2.57063639166882
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/644	94/9376	2.01347958239725	CASP3/MAPK9/TBK1/CASP8/TAB3/HSP90AA1/TRAF5/IL6/SRSF1/MAPK1/TAB2/ANAPC5/TRAF6	2.68182143055845
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/644	214/9376	1.63278574330992	CUL1/CASP3/CALR/MAPK9/APOBEC3G/BST2/BID/AP1S3/TBK1/CCNB1/CASP8/CCNB2/PPP3CA/ITPR1/AP1G1/TRAF5/PPP3CC/GNGT2/CHEK1/MAPK1/NRAS/TAB2/LIMK1/TRAF6	2.54296356203659
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/644	21/9376	3.46643005028098	AASDHPPT/PANK2/ALDH3A2/DPYD/PANK3	3.07275732670557
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/644	181/9376	1.68916646649051	ITGAX/CASP3/IL18/FCER1G/CASP10/SYK/MAPK9/BID/KSR1/CASP8/MALT1/ARHGEF12/RAB5B/RIPK2/PPP3CA/PPP3CC/HSPD1/IL6/MAPK1/RFX5/TRAF6	2.5424900756149
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/644	116/9376	1.88263011351467	RPE/ME2/SDHD/SHMT1/DLD/SUCLA2/RPIA/ACAT2/SUCLG2/DLAT/IDH3A/FH/GPT2/ALDH6A1/PSPH	2.59761001618572
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/644	56/9376	2.33984028393966	B4GALT1/MGAT5/DPM1/STT3B/OSTC/ALG5/ALG1/ALG13/B4GALT3	2.73093143758161
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/644	196/9376	1.63417416656103	CASP3/PIK3CG/SYK/PIK3R6/MAPK9/BID/TBK1/RB1/LEF1/CTNNB1/CASP8/PPP3CA/ITPR1/PPP3CC/CDK6/GNGT2/IL6/CLEC2B/MAPK1/IRF7/NRAS/MAP1LC3B	2.43661520662318
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/644	87/9376	2.00813878774898	CASP3/MAPK9/BCL2L11/AREG/LEF1/CTNNB1/POLK/MLH1/GADD45A/MAPK1/PMAIP1/NRAS	2.56547140073613
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/644	48/9376	2.42650103519669	HMGCS1/DLD/ACADM/ACAT2/ALDH3A2/HADHB/ALDH6A1/AUH	2.69073017730213
Genetic Information Processing	Transcription	hsa03040	Spliceosome	26/644	243/9376	1.55775375099047	SRSF6/HSPA8/NCBP1/PRPF8/SF3B1/PRPF38A/RBM22/LSM5/AQR/SF3B3/PPIL1/PHF5A/ISY1/LSM6/HNRNPA1/DHX38/HNRNPA3/SRSF1/MAGOHB/SNRNP40/SRSF8/DHX15/LSM8/THOC3/USP39/WBP11	2.39227232412635
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/644	200/9376	1.60149068322981	CASP3/IL18/CASP1/MAPK9/SEC24D/MYO1E/ARF6/ARPC5L/CDC42/CASP8/TAB3/ARHGEF12/ARPC1B/ACTR3/ARHGEF1/IL6/CYTH4/MAPK1/MYO1D/TAB2/TUBA1B/TRAF6	2.335010879889
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/644	41/9376	2.48568398727466	MDM2/RB1/DAPK2/RASSF1/MAPK1/NRAS/CDKN2A	2.58900517265877
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/644	91/9376	1.91986895092485	PIK3AP1/SYK/BANK1/INPP5D/VAV3/MALT1/CARD11/PPP3CA/PPP3CC/MAPK1/NRAS/DAPP1	2.39456930135013
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/644	227/9376	1.5392781897283	CASP3/CALR/BID/PRKACB/TBK1/MDM2/ADCY7/RB1/CTNNB1/CASP8/ARHGEF12/PTGER2/CCL3/PPP3CA/ITPR1/TRAF5/PPP3CC/CDK6/ARHGEF1/GNGT2/IL6/MAPK1/NRAS/CDKN2A	2.23362714773743
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/644	173/9376	1.59896600007181	OAS2/CASP3/IL18/CASP1/XPO1/BID/OAS1/MX1/TBK1/CASP8/EIF2S1/NXT1/RSAD2/CDK6/IL6/MAPK1/IRF7/PML/OAS3	2.15939563695518
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/644	75/9376	1.94120082815735	RPE/PYCR1/ALDH18A1/SHMT1/RPIA/MAT2A/IDH3A/GPT2/ASL/PSPH	2.22238766800643
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/644	36/9376	2.42650103519669	GALNT3/C1GALT1C1/B4GALT5/GALNT7/GCNT1/GALNT1	2.32874326452094
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/644	201/9376	1.52109020116807	GZMB/CCNA2/DDIT3/MDM2/ITGB7/KDM6A/IL2RB/ELK4/POLK/ETV6/CCNT2/CDK9/NSD2/DOT1L/SIX4/GADD45A/IL6/PML/SS18/BIRC2/ID2	2.0280544324582
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	25/644	250/9376	1.45590062111801	DMXL1/FUCA1/CTSW/VPS26A/GNPTAB/MANBA/IGF2R/STX17/GLA/AP1S3/AP5M1/GGA2/AP3S1/SORT1/OSBPL7/AP1G1/BLOC1S2/VPS26B/SPG11/SLC15A4/TTI1/LAMTOR3/MFSD8/PLEKHM1/ATP6V1E2	1.98413703881368
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/644	250/9376	1.45590062111801	VPS26A/STAM2/HSPA8/RAB11FIP4/IGF2R/ARF6/ARPC5L/MDM2/ITCH/CDC42/RAB8A/IL2RB/ARAP2/RAB5B/ARFGAP2/ARPC1B/SNX1/ACTR3/VPS26B/CYTH4/VPS25/CHMP5/PML/ARRB2/TRAF6	1.98413703881368
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/644	77/9376	1.89078002742599	ARHGEF6/MAPK9/RB1/CDC42/POLK/BRCA2/CDK6/GADD45A/MAPK1/CDKN2A	2.1314218719605
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/644	37/9376	2.36091992613732	ADSL/PPAT/GLS/GPT2/ASL/GFPT1	2.25244894375238
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/644	37/9376	2.36091992613732	LEF1/CTNNB1/POLK/GADD45A/MAPK1/NRAS	2.25244894375238
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/644	122/9376	1.67070563079116	MAPK9/VAV3/CDC42/MALT1/ITK/CARD11/PPP3CA/PPP3CC/PPP2R2D/PPP2R2A/MAPK1/PPP2R3B/NRAS/MAP3K8	2.02497109574942
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/644	47/9376	2.16836262719704	ME2/DLD/ACAT2/ALDH3A2/DLAT/FH/ACYP1	2.18062379796023
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/644	49/9376	2.07985803016859	GALNT3/C1GALT1C1/B4GALT1/GALNT7/B4GALT3/GALNT1/LFNG	2.05809502183241
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/644	13/9376	3.35977066411849	XRCC4/DCLRE1C/RAD50	2.31209497933254
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/644	163/9376	1.51842396067523	CASP3/CASP10/CCNA2/MAPK9/BID/TBK1/RB1/DDX3X/CASP8/CDK2/IL6/STAT4/MAPK1/IRF7/NRAS/TAB2/TRAF6	1.81321807919373
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/644	31/9376	2.34822680825486	HSPA5/SRPRA/SPCS3/SRP68/SRP54	2.04185952730123
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/644	73/9376	1.79494597124139	XPO1/APOBEC3G/BST2/MX1/MDFIC/CCNT2/CDK9/CPSF6/KAT2A	1.85165145447849
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/644	154/9376	1.51262402194079	MOCS2/COQ5/SHMT1/DLD/MMAB/ADSL/FECH/MAT2A/PANK2/ALDH3A2/LIAS/GCH1/PANK3/RFK/GSS/CTPS1	1.74188092585383
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/644	32/9376	2.27484472049689	ECHDC1/DLD/SUCLA2/SUCLG2/ALDH6A1	1.9617224961146
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/644	63/9376	1.84876269348319	SUV39H2/GCDH/DLD/EHMT1/ACAT2/NSD2/ALDH3A2/DOT1L	1.83562288698155
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/644	98/9376	1.63417416656103	SYK/ARF6/ARPC5L/INPP5D/VAV3/CDC42/VASP/ARPC1B/ACTR3/MAPK1/LIMK1	1.71382356055245
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/644	157/9376	1.48372037820944	COX6A2/CASP3/MAPK9/BCL2L11/BID/SDHD/DDIT3/NDUFB5/ITCH/CDC42/CASP8/EIF2S1/NDUFA8/NDUFA7/IL6/NDUFV3	1.65986975213834
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/644	44/9376	1.98531902879729	B4GALT1/STT3B/OSTC/ALG1/ALG13/B4GALT3	1.77904753230395
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/644	34/9376	2.14103032517355	POLR2M/CRCP/POLR2B/POLR2D/POLR1D	1.81004104108998
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/644	45/9376	1.94120082815735	KLRC1/GZMB/KLRD1/KIR2DL3/PRF1/IL6	1.7186845430615
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	25/644	275/9376	1.32354601919819	HSPA5/COX6A2/CASP3/PSMA2/MAPK9/NCAM1/HSPA8/SDHD/DDIT3/PRKACB/NDUFB5/PSMA6/PSMD6/STIP1/EIF2S1/PSMD12/NDUFA8/PPP3CA/ITPR1/NDUFA7/PPP3CC/IL6/MAPK1/NDUFV3/TUBA1B	1.47886850112972
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/644	57/9376	1.78794813119756	HACD4/ACSL3/ACADM/ACSL4/ACAT2/HADHB/HSD17B4	1.62039953603183
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/644	93/9376	1.56548453883657	CASP3/CKS2/RB1/POLK/CDK2/TRAF5/CDK6/GADD45A/BIRC2/TRAF6	1.48829746695248
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/644	59/9376	1.72733971997052	LEF1/CTNNB1/POLK/MLH1/GADD45A/MAPK1/NRAS	1.52193803763282
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/644	83/9376	1.57868742048941	ECI2/ACSL3/SLC27A2/ABCD3/ACSL4/FAR1/AGPS/PEX2/HSD17B4	1.43805940829342
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/644	18/9376	2.42650103519669	MMAB/MTRR/MMADHC	1.64508571662835
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/644	28/9376	2.07985803016859	B4GALT1/B3GNT2/B4GALT4/B4GALT3	1.55402511889908
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/644	73/9376	1.59550752999234	MDM2/RB1/POLK/CDK6/GADD45A/MAPK1/NRAS/CDKN2A	1.3871035566622
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/644	73/9376	1.59550752999234	RB1/POLK/RASSF1/CDK6/GADD45A/MAPK1/NRAS/CDKN2A	1.3871035566622
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	26/644	300/9376	1.26178053830228	CASP3/MAPK9/AREG/HSPA8/DDIT3/PRKACB/RRAS2/DUSP10/CDC42/ELK4/RASA2/PPP3CA/PPM1A/NF1/PPP3CC/PTPN7/GADD45A/MAPKAPK3/MAPK1/LAMTOR3/NRAS/MAP3K8/MKNK1/TAB2/ARRB2/TRAF6	1.25147577847806
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/644	19/9376	2.29879045439686	DLD/DLAT/LIAS	1.53893147507094
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/644	112/9376	1.42990239574091	SOCS1/CASP3/PIK3CG/PIK3R6/MAPK9/HSPA8/CASP8/MAPK1/BIRC2/TAB2/TRAF6	1.24294328337826
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/644	30/9376	1.94120082815735	PIGK/PIGA/PIGV/PIGB	1.40217347737506
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/644	76/9376	1.53252696959791	MDM2/RB1/POLK/CDK6/GADD45A/MAPK1/NRAS/CDKN2A	1.26583948256472
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	39/644	480/9376	1.18291925465839	HSPA5/COX6A2/CASP3/PSMA2/MAPK9/WDR41/BID/PPID/SDHD/DDIT3/TBK1/NDUFB5/PSMA6/CTNNB1/RAB8A/CASP8/NRBF2/PSMD6/EIF2S1/PSMD12/NDUFA8/ATP2A2/PPP3CA/ITPR1/HTT/NDUFA7/UBE2J1/CDK5/PPP3CC/SPG11/IL6/MAPK1/ACTR10/NRAS/DERL1/DNAH14/MAP1LC3B/NDUFV3/TUBA1B	1.11726028949986
Organismal Systems	Immune system	hsa04611	Platelet activation	12/644	126/9376	1.38657202011239	FCER1G/PIK3CG/SYK/PIK3R6/PRKACB/ADCY7/VASP/ARHGEF12/ITPR1/ARHGEF1/MAPK1/STIM1	1.18636009840129
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/644	77/9376	1.51262402194079	MDM2/RB1/POLK/CDK6/GADD45A/MAPK1/NRAS/CDKN2A	1.22658571007054
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/644	42/9376	1.73321502514049	ACSL3/ACSL4/GSS/SLC39A8/MAP1LC3B	1.29328372186768
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/644	31/9376	1.87858144660389	RPE/PGM2/RPIA/DERA	1.3305920682443
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/644	78/9376	1.49323140627488	SACM1L/PIK3CG/INPP5D/INPP5B/PPIP5K2/IMPA1/IP6K2/ALDH6A1	1.1878865392708
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/644	128/9376	1.36490683229814	DCK/ADCY7/PDE6D/HPRT1/PGM2/ADSL/PPAT/PAICS/PAPSS1/RRM2B/HDDC2/NUDT9	1.12884620569121
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/644	32/9376	1.81987577639752	B4GALT1/GLA/PGM2/GALE	1.26161933976676
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/644	105/9376	1.38657202011239	SYK/CYLD/TAB3/MALT1/CARD11/TRAF5/GADD45A/BIRC2/TAB2/TRAF6	1.0817663904814
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/644	105/9376	1.38657202011239	MAPK9/OPA1/SIAH1/RRAS2/TBK1/EIF2S1/RAB5B/MTX2/NRAS/MAP1LC3B	1.0817663904814
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/644	33/9376	1.76472802559759	DLD/DLAT/IDH3A/GPT2	1.19506770479422
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/644	69/9376	1.47700063011972	FCER1G/SYK/MAPK9/INPP5D/VAV3/MAPK1/NRAS	1.07996666266117
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/644	238/9376	1.22344590009917	OAS2/CASP1/SYK/MAPK9/OAS1/MX1/TBK1/RPS10/RPS21/RPL36A/RPL17/RPL22L1/RPS19/IL6/MAPK1/RSL24D1/OAS3/ADAM17/TAB2/TRAF6	0.948215391282441
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/644	23/9376	1.89900081015393	GLS/GPT2/ASL	1.17225000241216
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/644	23/9376	1.89900081015393	HMGCS1/HMGCR/ACAT2	1.17225000241216
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/644	83/9376	1.4032777071017	MTF2/PHC3/MBD5/JARID2/DCAF7/PCGF5/EED/TFDP1	1.00215985404025
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/644	83/9376	1.4032777071017	CASP3/IL18/CASP1/TBK1/CASP8/IL6/IRF7/POLR1D	1.00215985404025
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/644	109/9376	1.33568864322753	MAPK9/TBK1/CASP8/CCL3/IL6/MAPK1/IRF7/MAP3K8/TAB2/TRAF6	0.957308741429286
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/644	59/9376	1.48057690283188	GSTP1/GGCT/GSR/LAP3/RRM2B/GSS	1.00559373886146
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/644	47/9376	1.54883044799789	SOCS1/SOCS4/MAPK9/SOCS2/MAPK1	1.02433329181414
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/644	60/9376	1.45590062111801	CDC42/PPP3CA/PPP3CC/MAPKAPK3/MAPK1/NRAS	0.962061371975983
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/644	99/9376	1.32354601919819	MAPK9/JAG1/PRKACB/MDM2/ADCY7/RB1/MAPK1/NRAS/CDKN2A	0.878863823656691
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/644	37/9376	1.57394661742488	PGM2/GMDS/GALE/GFPT1	0.949934986886567
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/644	62/9376	1.40893608495292	JAG1/ITCH/NUMB/KAT2A/LFNG/ADAM17	0.877313618938918
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/644	140/9376	1.24791481810115	PIK3CG/PIK3R6/JAG1/PRKACB/RRAS2/ADCY7/TFAM/ITPR1/GNGT2/MAPK1/NRAS/MAP1LC3B	0.802594630332161
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/644	75/9376	1.35884057971015	HSPA5/PDIA4/PRKACB/ADCY7/GSR/ITPR1/TTF2	0.847303630925813
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	12/644	142/9376	1.23033855305748	SOCS1/SYK/MAPK9/CYLD/ATP2A2/PPP3CA/ITPR1/TYROBP/PPP3CC/MAPK1/TAB2/TRAF6	0.751082390414886
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	30/644	388/9376	1.12569635653455	COX6A2/CASP3/PSMA2/MAPK9/BID/PPID/SDHD/DDIT3/NDUFB5/PSMA6/CTNNB1/CASP8/NRBF2/PSMD6/EIF2S1/PSMD12/NDUFA8/ATP2A2/PPP3CA/ITPR1/NDUFA7/CDK5/PPP3CC/IL6/MAPK1/NRAS/SLC39A8/ADAM17/NDUFV3/TUBA1B	0.686718470376898
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/644	333/9376	1.13673922369575	CASP3/CCNA2/OASL/RBL1/JAG1/PRKACB/MX1/TBK1/HES6/MDM2/RB1/CDC42/CTNNB1/ITGB7/CASP8/CDK2/TBP/PPP2R2D/CDK6/TADA3/PPP2R2A/MAPK1/PPP2R3B/NRAS/LFNG/ATP6V1E2	0.68997073351587
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/644	103/9376	1.27214617379244	HBS1L/NCBP1/PELO/NXT1/CPSF6/PPP2R2D/PPP2R2A/PPP2R3B/MAGOHB	0.754192872181535
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/644	103/9376	1.27214617379244	CALR/MAPK9/CASP8/CCL3/PPP2R2D/IL6/PPP2R2A/MAPK1/TRAF6	0.754192872181535
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	10/644	117/9376	1.24435950522907	DPF3/DPF2/PHF6/BRD8/ACTL6A/ARID2/ACTR6/EPC2/MTA2/SS18	0.722290386086137
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/644	144/9376	1.21325051759834	CASP3/MAPK9/TBK1/LEF1/CTNNB1/CASP8/TAB3/ACADM/ALDH3A2/IL6/TAB2/TRAF6	0.700317776604651
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/644	144/9376	1.21325051759834	PSMA2/MAPK9/OPA1/PSMA6/OMA1/NRBF2/PSMD6/GTF2B/PSMD12/ATP2A2/ITPR1/TBP	0.700317776604651
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/644	78/9376	1.30657748049052	IRF8/CASP3/CASP1/MAPK9/IL6/MAPK1/TRAF6	0.738353757861252
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/644	28/9376	1.55989352262644	MOCS2/PCBD2/GCH1	0.80574350864858
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/644	106/9376	1.23614203679831	GSTP1/MDM2/RB1/LEF1/CTNNB1/CDK2/HSP90AA1/MAPK1/NRAS	0.663984710090376
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/644	133/9376	1.2041283332555	MAPK9/BCL2L11/MDM2/CCNB1/CDK2/CCNB2/GADD45A/IL6/MAPK1/PLK1/NRAS	0.643864294294733
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/644	67/9376	1.3037916010012	PRKACB/PPP3CA/ITPR1/PPP3CC/MAPK1/NRAS	0.6776935577719
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/644	68/9376	1.28461819510413	CCNA2/PIM1/LEF1/MAPK1/NRAS/PML	0.63967685566945
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/644	42/9376	1.38657202011239	GCDH/DLD/ACAT2/ALDH3A2	0.681856322904824
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/644	17/9376	1.71282426013884	PAPSS1/SEPHS2	0.7988475680463
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/644	56/9376	1.29991126885537	CUL1/PRKACB/CUL3/CSNK1G3/ARRB2	0.611294586690453
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/644	193/9376	1.13152898014353	PIK3CG/XCL2/PIK3R6/XCL1/PRKACB/FGR/VAV3/ADCY7/CDC42/ITK/CCL3/GNGT2/MAPK1/NRAS/ARRB2	0.501394451144765
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/644	18/9376	1.61766735679779	ACSL3/ACSL4	0.712313360610729
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/644	18/9376	1.61766735679779	FUCA1/MANBA	0.712313360610729
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/644	125/9376	1.16472049689441	FCER1G/SPTSSB/MAPK9/BID/ORMDL1/PPP2R2D/PPP2R2A/MAPK1/PPP2R3B/NRAS	0.50347744323138
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/644	31/9376	1.40893608495292	ALDH3A2/DPYD/ALDH6A1	0.619324609187369
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/644	31/9376	1.40893608495292	SHMT1/DLD/ACAT2	0.619324609187369
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/644	98/9376	1.18849030295348	SACM1L/INPP5D/DGKE/INPP5B/ITPR1/PPIP5K2/IMPA1/IP6K2	0.509385495610933
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/644	71/9376	1.23033855305748	SOCS1/SOCS4/MAPK9/SOCS2/MAPK1/NRAS	0.529065361042434
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/644	308/9376	1.08719851576994	COX6A2/CASP3/PSMA2/MAPK9/SDHD/NDUFB5/PSMA6/TFAM/CASP8/NRBF2/POLR2B/PSMD6/PSMD12/NDUFA8/POLR2D/ITPR1/HTT/TBP/NDUFA7/ACTR10/DNAH14/NDUFV3/TUBA1B	0.422571695162281
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/644	155/9376	1.12714886796233	PRKACB/ASH2L/ADCY7/RB1/LEF1/CTNNB1/CDK2/ITPR1/FH/CDK6/MAPK1/CDKN2A	0.433471994753169
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/644	59/9376	1.23381408569323	DCK/RRM2B/DPYD/HDDC2/CTPS1	0.4892494400901
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	20/644	268/9376	1.08649300083434	HSPA5/COX6A2/CASP3/PSMA2/MAPK9/SDHD/DDIT3/PRKACB/NDUFB5/PSMA6/PSMD6/EIF2S1/PSMD12/NDUFA8/ITPR1/NDUFA7/UBE2J1/SLC39A8/NDUFV3/TUBA1B	0.390129291852435
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/644	170/9376	1.11333576909024	DPF3/GSTP1/RB1/LEF1/CTNNB1/ACTL6A/POLK/ARID2/CDK6/GADD45A/MAPK1/NRAS/CDKN2A	0.404974501820633
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/644	46/9376	1.26600054010262	PSMA2/PSMA6/PSMD6/PSMD12	0.491125315460694
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/644	115/9376	1.13940048609236	PIK3CG/PIK3R6/KCNQ5/PRKACB/ADCY7/ITPR1/GNGT2/MAPK1/NRAS	0.408466058444996
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/644	34/9376	1.28461819510413	CUL1/BHLHE40/NFIL3	0.45149598815533
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/644	21/9376	1.38657202011239	CSGALNACT2/CHST12	0.481603768557882
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/644	133/9376	1.09466212114136	MAPK9/PRKACB/PPP3CA/ITPR1/PPP3CC/PPP2R2D/GNGT2/PPP2R2A/PPP2R3B/ARRB2	0.298584517166649
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/644	149/9376	1.0748259618992	FCER1G/PIK3CG/SYK/PIK3R6/ARF6/RRAS2/ADCY7/DGKE/CYTH4/MAPK1/NRAS	0.250026988939792
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/644	50/9376	1.16472049689441	PYCR1/ALDH18A1/LAP3/ALDH3A2	0.317144108962362
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/644	50/9376	1.16472049689441	IL18/IL6/KLRB1/KLRK1	0.317144108962362
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/644	93/9376	1.0958391771856	ACP1/NECTIN1/CDC42/LEF1/CTNNB1/PTPRJ/MAPK1	0.252238911666093
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/644	93/9376	1.0958391771856	MAPK9/JAG1/IL2RB/PPP3CA/PPP3CC/STAT4/MAPK1	0.252238911666093
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/644	93/9376	1.0958391771856	MAPK9/PRKACB/ADCY7/CDC42/ITPR1/MAPK1/NRAS	0.252238911666093
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/644	23/9376	1.26600054010262	B4GALT1/B4GALT3	0.346850781729041
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/644	168/9376	1.03992901508429	CASP1/MAPK9/BID/PPID/CYLD/CASP8/HSP90AA1/TRAF5/DNM1L/STAT4/CHMP5/BIRC2	0.14181830539928
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/644	38/9376	1.14939522719843	PGM2/GALE/GFPT1	0.25059551555257
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/644	38/9376	1.14939522719843	CD38/NNT/SIRT7	0.25059551555257
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/644	67/9376	1.08649300083434	DLD/PGM2/ALDH3A2/DLAT/GAPDHS	0.192947235093434
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/644	170/9376	1.0276945560833	MAPK9/PRKACB/ARPC5L/CDC42/RAB8A/VASP/ARPC1B/ACTR3/RAB8B/PPP2R2D/PPP2R2A/TUBA1B	0.0989589530561056
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/644	39/9376	1.11992355470616	SHMT1/DLD/MAT2A	0.203800303119857
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/644	10/9376	1.45590062111801	PAPSS1	0.391710141325833
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/644	69/9376	1.05500045008552	PRKACB/PTGER2/PPP3CA/ITPR1/PPP3CC	0.124525312490276
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/644	70/9376	1.03992901508429	CDC42/FH/CUL2/MAPK1/NRAS	0.091060032714676
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/644	85/9376	1.0276945560833	DCK/HPRT1/ADSL/RRM2B/HDDC2/CTPS1	0.0696537253943059
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/644	41/9376	1.06529313740342	SHMT1/DLD/PSPH	0.113782117815431
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/644	71/9376	1.0252821275479	CASP3/MAPK9/CDC42/ADAM17/ATP6V1E2	0.0580705998257741
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/644	101/9376	1.00904003443823	CASP3/MAPK9/PIM1/CDC42/IL6/MAPK1/NRAS	0.0248053592410514
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/644	116/9376	1.00406939387449	PRKACB/ADCY7/PPP3CA/ITPR1/PPP3CC/GLS/GNGT2/MAPK1	0.0119763626079904
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/644	27/9376	1.07844490453186	HMGCS1/ACAT2	0.11085001324742
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/644	27/9376	1.07844490453186	HACD4/HSD17B4	0.11085001324742
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/644	148/9376	0.983716635890549	JAG1/RB1/LEF1/CTNNB1/POLK/BRCA2/CDK6/GADD45A/MAPK1/NRAS	-0.0542241692802144
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/644	12/9376	1.21325051759834	COQ5	0.200734362376303
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/644	12/9376	1.21325051759834	NCAM1	0.200734362376303
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/644	149/9376	0.977114510817458	MAPK9/PRKACB/NDUFB5/ADCY7/NDUFA8/ITPR1/NDUFA7/GNGT2/MAPK1/NDUFV3	-0.0764706500991341
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/644	89/9376	0.981506036708772	PRKACB/ADCY7/ITPR1/MAPK1/NRAS/TUBA1B	-0.0476057027087197
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/644	28/9376	1.03992901508429	HACD4/HADHB	0.0574618983980762
NA	NA	hsa04517	IgSF CAM signaling	20/644	299/9376	0.973846569309707	SRGAP3/ITGAX/SH2D1B/MAPK9/NCAM1/ARF6/ARPC5L/INPP5D/VAV3/CABLES1/NECTIN1/CDC42/CTNNB1/DOK2/ARPC1B/CD96/ACTR3/MAPK1/TUBA1B/TRAF6	-0.124814430807382
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/644	44/9376	0.992659514398645	GZMB/PRF1/HSPD1	-0.0132536492377944
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/644	44/9376	0.992659514398645	PRKACB/RAB5B/NSF	-0.0132536492377944
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/644	76/9376	0.957829355998692	HMGCS1/ACSL3/ACADM/SLC27A2/ACSL4	-0.100241432320963
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/644	122/9376	0.954688931880664	PRKACB/MDM2/MED30/CTNNB1/ATP2A2/KAT2A/MAPK1/NRAS	-0.136801599758386
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/644	122/9376	0.954688931880664	SOCS1/MAPK9/PRKACB/ADCY7/ITPR1/SOCS2/MAPK1/NRAS	-0.136801599758386
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/644	138/9376	0.949500405076965	SOCS1/SOCS4/MAPK9/PRKACB/PRKAR1A/SOCS2/MAPK1/NRAS/MKNK1	-0.162296878533993
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/644	154/9376	0.945390013712995	CD38/PIK3CG/PIK3R6/PRKACB/ADCY7/PPP3CA/ITPR1/PPP3CC/MAPK1/NRAS	-0.185563082109054
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/644	30/9376	0.970600414078675	SHMT1/IL6	-0.0437986435959655
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/644	62/9376	0.939290723301943	HSPA8/PRKACB/ADCY7/NRAS	-0.130243031131059
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/644	109/9376	0.934982050259274	MAPK9/IL2RB/PPP3CA/HSP90AA1/PPP3CC/IL6/MAPK1	-0.185416614152235
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/644	78/9376	0.933269628921803	ARPC5L/CDC42/CTNNB1/ARPC1B/ACTR3	-0.160711804957852
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/644	232/9376	0.941315056757336	ITGAX/ARHGEF6/RRAS2/ARPC5L/VAV3/CDC42/ITGB7/ARHGEF12/ARPC1B/ACTR3/ARHGEF1/MAPK1/NRAS/DIAPH3/LIMK1	-0.245795700012346
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/644	63/9376	0.924381346741595	LEF1/CTNNB1/POLK/GADD45A	-0.163540800826443
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/644	157/9376	0.9273252363809	CASP3/CALR/HAVCR2/CASP1/RAB5B/PTGER2/TMEM30A/ATP2A2/MAPK1/ADAM17	-0.249380938470445
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/644	80/9376	0.909937888198758	BCL2L11/NF1/IL6/MAPK1/NRAS	-0.219690243660681
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/644	32/9376	0.909937888198758	ATG16L1/ATG10	-0.138586972928924
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/644	15/9376	0.970600414078675	SLC33A1	-0.0309454946364844
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/644	15/9376	0.970600414078675	ACP1	-0.0309454946364844
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/644	65/9376	0.895938843764931	GLA/AGK/DGKE/ALDH3A2	-0.228622447865159
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/644	65/9376	0.895938843764931	ITPR1/MAPK1/NRAS/ARRB2	-0.228622447865159
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/644	16/9376	0.909937888198758	GLA	-0.0979119954338546
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/644	99/9376	0.882364012798795	MAPK9/PRKACB/ADCY7/PTGER2/ITPR1/TRPV2	-0.319540366367325
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/644	115/9376	0.886200378071834	STK39/PRKACB/ADCY7/ITPR1/ARHGEF1/MAPK1/ARRB2	-0.333451369679817
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/644	178/9376	0.899713866983041	CUL1/MAPK9/CTNNBIP1/PRKACB/SIAH1/CACYBP/LEF1/CTNNB1/CCDC88C/PPP3CA/PPP3CC	-0.36683933065939
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/644	51/9376	0.856412130069419	PDIA4/PRKACB/ATP6V1E2	-0.279222318650535
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/644	100/9376	0.873540372670807	IL18/XCL2/XCL1/IL2RB/CCL3/IL6	-0.345257591037715
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/644	101/9376	0.864891458089908	PRKACB/ADCY7/LEF1/CTNNB1/MAPK1/NRAS	-0.370730437092449
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/644	17/9376	0.856412130069419	HSD17B4	-0.160915988847871
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/644	52/9376	0.839942666029623	HSD17B7/PRKACB/ADCY7	-0.314302493479754
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/644	35/9376	0.831943212067436	GMDS/TIGAR	-0.270498650709507
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/644	150/9376	0.873540372670807	RB1/LEF1/CTNNB1/POLK/CDK2/MLH1/GADD45A/MAPK1/NRAS	-0.423996733123897
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/644	70/9376	0.831943212067436	CASP3/BID/PRF1/CASP8	-0.383261559914659
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/644	36/9376	0.808833678398896	GYG1/PGM2	-0.312076383295743
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/644	183/9376	0.875131520890609	XPO1/RIOK2/UTP18/RPP30/NXT1/HEATR1/EFL1/UTP14A/POP5/WDR36/NMD3	-0.463256418475573
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/644	120/9376	0.849275362318841	MAPK9/CDC42/SORT1/RIPK2/MAPK1/NRAS/TRAF6	-0.45126838316046
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/644	71/9376	0.820225702038317	GLS/MAPK1/NRAS/TIGAR	-0.412924161390886
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/644	37/9376	0.786973308712439	IL18/IL6	-0.352578969979249
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/644	55/9376	0.794127611518916	UGCG/GLA/B4GALT5	-0.415833910389195
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/644	154/9376	0.850851012341695	PIK3CG/PIK3R6/PRKACB/ADCY7/ATP2A2/PPP2R2D/PPP2R2A/MAPK1/PPP2R3B	-0.506803750102868
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/644	138/9376	0.844000360068413	COX6A2/SDHD/NDUFB5/PPA2/NDUFA8/NDUFA7/NDUFV3/ATP6V1E2	-0.501355598038162
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/644	89/9376	0.81792169725731	PRKACB/ADCY7/GLS/GNGT2/NSF	-0.468691616479433
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/644	122/9376	0.835352815395581	CCNA2/RAB8A/HMGCR/CAB39/PPP2R2D/PPP2R2A/PPP2R3B	-0.497097049009686
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/644	38/9376	0.766263484798954	DCLRE1C/RFX5	-0.392069570284656
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/644	139/9376	0.83792841503195	HSPA8/PRKACB/FKBP4/ADCY7/ITPR1/HSP90AA1/MAPK1/NRAS	-0.522781867678926
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/644	235/9376	0.867345050878816	COX6A2/DPF3/SDHD/PRKACB/NDUFB5/ACSL3/ADCY7/ACTL6A/ACSL4/NDUFA8/NDUFA7/NRAS/NDUFV3/KDM3A	-0.559283803221212
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/644	90/9376	0.808833678398896	PRKACB/ADCY7/EHMT1/SESN1/NRAS	-0.494868724002515
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/644	90/9376	0.808833678398896	PPP3CA/PPP3CC/MAPK1/NRAS/TRAF6	-0.494868724002515
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/644	204/9376	0.856412130069419	CASP3/PRKACB/RRAS2/MDM2/VAV3/CDC42/CTNNB1/ARHGEF12/ITPR1/ARHGEF1/MAPK1/NRAS	-0.563083137727407
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/644	39/9376	0.746615703137442	GZMB/PRF1	-0.430605952541424
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/644	20/9376	0.727950310559006	GMDS	-0.330742369998575
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/644	157/9376	0.83459271274281	TP53BP2/AREG/LEF1/CTNNB1/RASSF1/PPP2R2D/PPP2R2A/BIRC2/ID2	-0.567589386905244
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/644	238/9376	0.856412130069419	MAPK9/PRKACB/ARF6/RRAS2/TBK1/CDC42/KSR1/RAB5B/RASA2/NF1/RASSF1/GNGT2/MAPK1/NRAS	-0.609329722358794
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/644	110/9376	0.794127611518916	CUL1/RBL1/ID3/MAPK1/TFDP1/ID2	-0.589820694443954
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/644	144/9376	0.808833678398896	ID3/SMARCAD1/JARID2/CTNNB1/PCGF5/MAPK1/NRAS/ID2	-0.627792958315496
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/644	60/9376	0.727950310559006	ITPR1/MAPK1/NRAS	-0.574091118427085
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/644	22/9376	0.661773009599097	ALDH3A2	-0.431313078436489
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/644	130/9376	0.783946488294314	MAPK9/PRKACB/ADCY7/GNGT2/MAPK1/NRAS/ARRB2	-0.673639848688633
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/644	97/9376	0.750464237689697	PRKACB/ADCY7/ITPR1/GNGT2/MAPK1	-0.670872181356593
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/644	23/9376	0.63300027005131	LNPEP	-0.478548438954078
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/644	23/9376	0.63300027005131	GLS	-0.478548438954078
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/644	115/9376	0.759600324061572	CASP3/PRKACB/ITPR1/GNGT2/MAPK1/NRAS	-0.704410083742223
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/644	166/9376	0.789343710244706	PIK3CG/PIK3R6/ADCY7/VASP/ATP2A2/PPP3CA/ITPR1/PPP3CC/MAPK1	-0.74365305784037
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/644	63/9376	0.693286010056196	LTC4S/PTGIS/PTGES3	-0.663331722778441
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/644	116/9376	0.753052045405868	TXK/VAV3/CDC42/CTNNB1/ITK/VASP	-0.726776109842789
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/644	24/9376	0.606625258799172	HS6ST2	-0.52400031775558
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/644	99/9376	0.735303343998996	MAPK9/SLC44A1/DGKE/MAPK1/NRAS	-0.719008429708664
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/644	184/9376	0.791250337564137	SRGAP3/SEMA4D/CDC42/ARHGEF12/PPP3CA/CDK5/PPP3CC/MAPK1/NRAS/LIMK1	-0.776607166525157
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/644	82/9376	0.710195424935616	GSTP1/HPRT1/RRM2B/DPYD	-0.715784908838829
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/644	65/9376	0.671954132823698	PRKACB/ADCY7/ITPR1	-0.720717046392186
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/644	46/9376	0.63300027005131	MMAB/FECH	-0.677603354021404
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/644	102/9376	0.713676775057849	CD38/ADCY7/RAB8A/ATP2A2/ITPR1	-0.789577611601952
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/644	66/9376	0.661773009599097	IL18/IL6/STAT4	-0.748819416385325
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/644	86/9376	0.677163079589773	MAPK9/AREG/MAPK1/NRAS	-0.816763408474271
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/644	86/9376	0.677163079589773	LEF1/CTNNB1/ITGB7/ATP2A2	-0.816763408474271
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/644	49/9376	0.59424515147674	PRKACB/CDK5	-0.773325761813072
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/644	69/9376	0.63300027005131	PRKACB/PPP3CA/PPP3CC	-0.830916037680616
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/644	227/9376	0.769639094864148	COX6A2/PRKD3/MAPK9/ACP1/SDHD/NDUFB5/NDUFA8/NDUFA7/PTPRJ/MAPK1/NRAS/NDUFV3	-0.954127908914782
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/644	28/9376	0.519964507542147	ATP6V1E2	-0.690819711852428
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/644	50/9376	0.582360248447205	ITGB7/IL6	-0.804101428605929
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/644	70/9376	0.623957409050577	MAPK9/ACSL3/ACSL4	-0.857583152543994
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/644	29/9376	0.502034696937246	RASSF1	-0.729346107133169
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/644	51/9376	0.570941420046279	LPCAT4/AGPS	-0.834351338936247
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/644	91/9376	0.639956316974951	PRKACB/ADCY7/GNGT2/ARRB2	-0.937252583261998
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/644	52/9376	0.559961777353082	APOC2/SORT1	-0.864097302969712
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/644	217/9376	0.738014139737241	JAG1/PRKACB/ADCY7/RB1/PTGES3/KPNA3/HSP90AA1/CDC6/MAPK1/NRAS/ARRB2	-1.06036503402693
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/644	93/9376	0.626193815534629	CD38/PRKACB/ADCY7/ITPR1	-0.983819643620294
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/644	31/9376	0.469645361650972	ALDH3A2	-0.803210308926489
NA	NA	hsa04981	Folate transport and metabolism	1/644	31/9376	0.469645361650972	SHMT1	-0.803210308926489
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/644	54/9376	0.53922245226593	MAT2A/GSS	-0.922158020879636
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/644	54/9376	0.53922245226593	GZMB/PRF1	-0.922158020879636
Human Diseases	Immune disease	hsa05310	Asthma	1/644	32/9376	0.454968944099379	FCER1G	-0.838690129276767
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/644	168/9376	0.693286010056196	SOCS1/SOCS4/STAM2/PIM1/IL2RB/SOCS2/IL6/STAT4	-1.08937468665966
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/644	95/9376	0.613010787839163	IL18/CCL3/IL6/ATP6V1E2	-1.02952046332692
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/644	76/9376	0.574697613599215	PRKACB/ADCY7/ITPR1	-1.01096204224476
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/644	205/9376	0.710195424935616	COX6A2/MAPK9/SDHD/NDUFB5/GSR/NDUFA8/ATP2A2/NDUFA7/GFPT1/NDUFV3	-1.13931949695742
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/644	134/9376	0.651895800500602	PRKACB/ADCY7/ARHGEF12/ITPR1/ARHGEF1/MAPK1	-1.10217457392003
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/644	78/9376	0.559961777353082	MAPK1/TAB2/TRAF6	-1.05977736777695
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/644	98/9376	0.59424515147674	PRKD3/PRKACB/ADCY7/ITPR1	-1.09653192431109
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/644	155/9376	0.65750350631136	CALR/STX18/SEC22B/STX7/RAB5B/TUBA1B/ATP6V1E2	-1.16762847121189
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/644	362/9376	0.764146734840946	PIK3AP1/PIK3CG/SYK/PIK3R6/BCL2L11/AREG/MDM2/ITGB7/IL2RB/CDK2/HSP90AA1/PPP2R2D/CDK6/GNGT2/IL6/PPP2R2A/MAPK1/PPP2R3B/NRAS	-1.24282250763334
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/644	59/9376	0.493525634277292	PRKACB/ADCY7	-1.05978345622399
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/644	36/9376	0.404416839199448	RPE	-0.972281295249913
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/644	194/9376	0.675417813920727	KIF18A/KIF2C/MYO1E/KIF14/KIF11/ACTR10/DNAH14/MYO1D/TUBA1B	-1.24059095381507
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/644	158/9376	0.645019262520638	WDR59/CAB39/TTI1/MAPK1/LAMTOR3/NRAS/ATP6V1E2	-1.22204356160596
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/644	103/9376	0.565398299463306	CASP3/PRKACB/RAB5B/IL6	-1.20440239969251
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/644	104/9376	0.559961777353082	ETNK1/PGS1/DGKE/LPCAT4	-1.22544004574276
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/644	38/9376	0.383131742399477	MAPK1	-1.03473465612188
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/644	105/9376	0.554628808044957	PRKACB/ADCY7/ITGB7/ATP2A2	-1.24630744513151
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/644	107/9376	0.54426191443664	PRKACB/PPP3CA/ITPR1/PPP3CC	-1.28754518705482
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/644	203/9376	0.645473181776459	MAPK9/VAV3/CDC42/CTNNB1/ITGB7/VASP/PARVG/MAPK1/BIRC2	-1.38679773472606
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/644	109/9376	0.534275457291014	MAPK9/SLC27A2/IL6/GFPT1	-1.32814196973375
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/644	110/9376	0.529418407679277	CUL2/IL6/MAPK1/MKNK1	-1.34820780787052
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/644	90/9376	0.485300207039337	PRKACB/ADCY7/HMGCR	-1.33239384245876
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/644	43/9376	0.338581539794887	ACAT2	-1.18051528655415
NA	NA	hsa04518	Integrin signaling	6/644	154/9376	0.567234008227797	ITGAX/ARHGEF6/CDC42/CTNNB1/ITGB7/PARVG	-1.47052575408431
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/644	45/9376	0.323533471359558	ABCD3	-1.23526513353049
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/644	212/9376	0.618071018399156	PRKD3/VAV3/ADCY7/CDC42/CTNNB1/EVL/VASP/MAPK1/NRAS	-1.52749470481318
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/644	99/9376	0.441182006399398	ITGB7/ATP2A2/IL6	-1.51794455639134
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/644	100/9376	0.436770186335404	CD38/CD7/IL6	-1.53771897619352
NA	NA	hsa04519	Cadherin signaling	19/644	404/9376	0.684705737654511	MAPK9/KRT81/MYO1E/RRAS2/ARPC5L/VAV3/CDC42/LEF1/CTNNB1/EVL/KRT86/VASP/ARPC1B/ACTR3/MAPK1/NRAS/TMC6/MYO1D/TMC8	-1.75927538420883
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/644	79/9376	0.368582435726079	NSF/ATP6V1E2	-1.5304900027696
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/644	53/9376	0.274698230399625	PRKACB	-1.43797235927153
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/644	86/9376	0.338581539794887	PRKACB/ADCY7	-1.6733600212097
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/644	87/9376	0.334689797958164	COX6A2/ATP2A2	-1.69305488162737
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/644	61/9376	0.238672232970166	ATP7A	-1.62000690575594
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/644	323/9376	0.585966194258024	SOCS1/SPRY2/CASP3/BCL2L11/PIM1/MDM2/RASSF1/CDCA5/GLS/CDK6/MAPK1/NRAS/CDKN2A	-2.05642328105162
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/644	226/9376	0.51536305172319	MAPK9/PRKACB/RRAS2/VAV3/ADCY7/PTGER2/ATP2A2/MAPK1	-2.00277380365647
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/644	142/9376	0.410112851019158	MAPK9/GSTP1/CTNNB1/HSP90AA1	-1.92348976778108
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/644	66/9376	0.220591003199699	HSD17B7	-1.72557662952233
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/644	68/9376	0.214103032517355	CYP26A1	-1.76629642688702
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/644	254/9376	0.515870298821343	CD38/CYSLTR1/PRKACB/ADCY7/ATP2A2/PPP3CA/ITPR1/PPP3CC/STIM1	-2.1242482051906
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/644	70/9376	0.207985803016859	GSTP1	-1.80622633780266
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/644	73/9376	0.199438441249043	GSTP1	-1.86473172805182
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/644	79/9376	0.18429121786304	GSTP1	-1.97719260101291
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/644	86/9376	0.169290769897443	PRKACB	-2.10165832757742
NA	NA	hsa04382	Cornified envelope formation	6/644	217/9376	0.402553167129404	UGCG/KRT81/KRT86/PPP2R2D/PPP2R2A/PPP2R3B	-2.41811420902917
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/644	88/9376	0.165443252399774	ITGAX	-2.13603229189516
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/644	89/9376	0.163584339451462	ITGB7	-2.15303527156229
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/644	160/9376	0.272981366459627	NCAM1/NECTIN1/ITGB7	-2.51887147726786
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/644	191/9376	0.30490065363728	PRKACB/GNGT2/MAPK1/NRAS	-2.63569827163186
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/644	233/9376	0.31242502599099	LBR/FMNL3/ITGB7/LMNB1/DIAPH3	-2.88619300684432
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/644	298/9376	0.34199007878611	IL18/XCL2/XCL1/TNFRSF18/IL2RB/CCL3/IL6	-3.13485308906077
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/644	195/9376	0.223984710941233	CASP1/SYK/MAPK1	-2.97381739965928
NA	NA	hsa04082	Neuroactive ligand signaling	3/644	199/9376	0.219482505696183	PRKACB/ADCY7/GNGT2	-3.02225094728826
NA	NA	hsa04081	Hormone signaling	3/644	219/9376	0.199438441249043	PRKACB/ADCY7/GNGT2	-3.25545645853238
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/644	370/9376	0.0786973308712439	CYSLTR1/PTGER2	-4.91031019649593
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/644	449/9376	0.0972762107651233	PRKACB/NCALD/ARRB2	-5.32349681943937