category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/251	187/9376	4.19489954620023	OAS2/NAIP/PRKCD/OAS1/BIRC2/GBP3/RIPK2/IFI16/NLRP3/PKN2/TRAF3/CARD6/CASP5/TRPM2/NLRC4/TBK1/CXCL1/ATG5/TLR4/HSP90AA1/TANK	7.31896967169264
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/251	173/9376	3.88660387352325	IFNGR2/MX1/OAS2/RSAD2/OAS1/NXF1/TRIM25/NLRP3/TRAF3/EP300/TBK1/EIF2S1/BID/ICAM1/SOCS3/NUP98/TLR4/NXT1	6.35552736484195
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	20/251	216/9376	3.45875756234322	HSPA5/NLRP3/DDIT3/TRAF3/NCF2/HSPA1A/HSPD1/STAT3/TICAM2/TBK1/CASP7/EIF2S1/BID/CXCL1/ICAM1/TLR4/ABCA1/HSP90AA1/HSPA1B/TANK	6.06318625871059
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/251	56/9376	6.00341491178145	NAIP/HSPA1A/HSPD1/NLRC4/SEC22B/CASP7/CXCL1/TLR4/HSPA1B	6.22814389947744
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/251	136/9376	3.57065854230138	MX1/OAS2/OAS1/BBC3/TRAF3/HSPA1A/STAT3/STAT5A/TBK1/EIF2S1/BID/TLR4/HSPA1B	5.00822606990607
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/251	156/9376	3.1128818061089	MX1/OAS2/RSAD2/RB1/OAS1/IFIT1/TRAF3/STAT3/GRB2/TBK1/EIF2S1/BID/SOCS3	4.41344891919267
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/251	157/9376	3.09305453345852	SIGLEC10/SIRPA/ATP11B/ADAM17/HAVCR2/HIF1A/PTGER2/ATP2A2/CASP7/DUSP2/TMEM30A/CEBPB/ABCA1	4.38626155080097
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/251	78/9376	3.83123914598018	PNPT1/HSPD1/LSM6/PATL1/BTG2/BTG3/LSM2/DIS3	4.16423420584913
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/251	119/9376	3.13904047674847	ADAM17/BIRC2/TRAF3/ITCH/MAP3K8/CASP7/CXCL1/ICAM1/SOCS3/CEBPB	3.89460497196233
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/251	110/9376	3.05628395508874	IFNGR2/PFKFB3/MKNK1/HIF1A/EP300/HK2/STAT3/TLR4/PDK1	3.59781927213353
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/251	91/9376	3.28391926798301	LILRB1/INPPL1/PIK3AP1/GRB2/NFKBIE/LILRA5/DAPP1/LILRA1	3.63091893554103
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/251	72/9376	3.63169544046038	MAP3K1/TRIM25/TRAF3/TBK1/AZI2/ATG5/TANK	3.71768926822004
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/251	163/9376	2.52086133991641	MAP3K1/RB1/TRAF3/EP300/STAT3/STAT5A/GRB2/TICAM2/TBK1/BID/TLR4	3.24854546511818
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/251	238/9376	2.19732833372393	MX1/OAS2/TLR8/CGAS/ADAM17/OAS1/NLRP3/TRAF3/STAT3/TBK1/RPS10/RPL36A/C3AR1/TLR4	3.10300320295094
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/251	168/9376	2.44583570479985	IFNGR2/BIRC2/NLRP3/STAT3/STAT5A/CHMP5/TICAM2/BID/TLR4/PPID/HSP90AA1	3.13615120457855
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/251	83/9376	3.1503864061825	CGAS/ZCCHC3/IFI16/NLRP3/POLR3K/TBK1/CASP7	3.26350021729475
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/251	108/9376	2.76700604987458	AHCTF1/NXF1/ACIN1/NMD3/GLE1/NUP98/NUP54/NXT1	3.06311261583258
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/251	180/9376	2.28277999114652	IFNGR2/OAS2/CGAS/OAS1/BIRC2/NXF1/TRAF3/TBK1/EIF2S1/BID/SOCS3	2.88200686379294
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/251	181/9376	2.27016794699654	IFNGR2/TLR1/RIPK2/EP300/HSPD1/VDR/BID/RFXANK/PLK3/CEBPB/TLR4	2.86174301880946
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/251	32/9376	4.66932270916335	BIRC2/BBC3/CASP7/BID	3.44826429570083
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/251	90/9376	2.9053563523683	IFNGR2/HIF1A/EML4/STAT3/TICAM2/NFKBIE/TLR4	3.01223735312289
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/251	33/9376	4.52782808161294	STX6/SNAP23/SEC22B/VAMP7	3.36687715446272
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/251	142/9376	2.36754390887156	IFNGR2/LILRB1/SIRPA/NCF2/ATP2A2/GRB2/LILRA5/SOCS3/LILRA1	2.72330685309163
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/251	169/9376	2.21033027652703	PRKCD/HIF1A/SH3GLB1/TBK1/EIF2S1/ATG5/DDIT4/RAB8A/VMP1/TANK	2.63326302148874
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/251	196/9376	2.09643060411416	GNG5/RB1/HIF1A/CCR1/TRAF3/EP300/STAT3/TBK1/BID/CXCL1/ICAM1	2.57272819903388
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/251	250/9376	1.94243824701195	RUFY1/MDM2/SH3GLB1/ITCH/HSPA1A/VPS26A/CHMP5/WASHC4/RAB10/SNX2/RAB8A/HSPA1B/SNX1	2.50489045171196
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/251	253/9376	1.91940538242288	CGAS/NAIP/PRKCD/RIPK2/NLRP3/MDM2/UBE2D1/HK2/NLRC4/TBK1/ATG5/TLR4/PPID	2.45869426047489
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/251	82/9376	2.73326207365659	HSPA5/HSPA1A/RFXANK/IFI30/HSP90AA1/HSPA1B	2.61442319926416
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/251	105/9376	2.49030544488712	BIRC2/TRIM25/TRAF3/TICAM2/CXCL1/ICAM1/TLR4	2.54690478614475
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/251	62/9376	3.01246626397635	ADAM17/ITCH/EP300/TLE4/SPEN	2.63671019925831
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/251	109/9376	2.39891808911144	TLR8/TLR1/TRAF3/MAP3K8/TICAM2/TBK1/TLR4	2.43636311433186
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/251	109/9376	2.39891808911144	IFNGR2/HIF1A/STAT3/AHR/STAT5A/NFKBIE/HSP90AA1	2.43636311433186
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/251	137/9376	2.18128944077704	LMNB1/BIRC2/BBC3/DDIT3/CASP7/EIF2S1/BID/PARP4	2.30999044953461
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/251	70/9376	2.6681844052362	ADIPOR2/STAT3/ACSL1/NFKBIE/SOCS3	2.32336592296253
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/251	94/9376	2.38433500042384	TRAF3/USP25/TBK1/CXCL1/CEBPB/HSP90AA1	2.23712580060848
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/251	71/9376	2.63060434319062	SOCS6/STAT3/STAT5A/GRB2/SOCS3	2.28731323409981
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/251	174/9376	1.93213353482621	HSPH1/HSPA5/DDIT3/UBE2D1/HSPA1A/EIF2S1/HERPUD1/HSP90AA1/HSPA1B	2.05834280027681
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/251	73/9376	2.55853299132238	MX1/EP300/ELL/TRIM5/MAP1S	2.2170321034008
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/251	73/9376	2.55853299132238	RB1/EML4/STAT3/STAT5A/GRB2	2.2170321034008
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	10/251	205/9376	1.82217471577106	OAS2/RB1/OAS1/MDM2/TRAF3/STAT3/NFKBIE/TBK1/BID/ICAM1	1.97396188662606
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/251	35/9376	3.20182128628344	PFKFB3/HK2/PFKFB4	2.16433989341768
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/251	248/9376	1.65685644518699	CYFIP1/NAIP/SNX18/BIRC2/RIPK2/NLRP3/CASP5/NLRC4/CASP7/TLR4/HSP90AA1	1.7386595594752
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/251	83/9376	2.25027600441607	PHC2/UBE2D1/EP300/SUZ12/EZH2	1.89746177726905
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/251	17/9376	4.39465666744786	CA13/CA2	2.32333404339164
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/251	138/9376	1.89479762110976	INPPL1/MKNK1/HK2/FLOT2/GRB2/SOCS3/PPP1R3B	1.75623022614404
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/251	139/9376	1.88116598354782	FKBP4/FKBP5/PRKCD/HSPA1A/GRB2/HSP90AA1/HSPA1B	1.73582410102512
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/251	112/9376	2.00113830392715	IFNGR2/BIRC2/HSPA1A/STAT3/TLR4/HSPA1B	1.76770535877613
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/251	168/9376	1.7787896034908	IFNGR2/SOCS6/EP300/STAT3/STAT5A/PTPN2/GRB2/SOCS3	1.68926659162773
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	10/251	227/9376	1.6455762851677	GNG5/CGAS/RB1/CCR1/PTGER2/MDM2/STAT3/GRB2/TBK1/BID	1.63297578843929
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/251	39/9376	2.87342935948514	MTHFS/MTHFD2/GART	1.94433909423573
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/251	142/9376	1.84142304023343	MAP3K1/BIRC2/MDM2/ITCH/UBE2D1/UBE2A/SOCS3	1.67559748316068
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/251	41/9376	2.73326207365659	NBN/BRCA2/UIMC1	1.84461214493586
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/251	20/9376	3.73545816733068	MSMO1/SQLE	2.03098179821564
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/251	42/9376	2.6681844052362	ACSL1/SLC11A2/ATG5	1.79697016352284
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/251	122/9376	1.83711057409705	MAP3K1/EP300/STAT3/STAT5A/GRB2/SOCS3	1.54349084530895
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/251	71/9376	2.10448347455249	HIF1A/HK2/GLS/PDK1	1.54930267341569
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/251	23/9376	3.24822449333102	CA2/GLS	1.79033453084968
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/251	157/9376	1.66549090263151	SAV1/BIRC2/MOB1A/BBC3/ID2/FZD2/TP53BP2	1.39462069045908
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/251	157/9376	1.66549090263151	ADIPOR2/DDIT3/ITCH/CASP7/EIF2S1/BID/SOCS3	1.39462069045908
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/251	47/9376	2.38433500042384	PRKCD/HK2/SOCS3	1.57789697723535
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/251	250/9376	1.49418326693227	ATP6V1C1/TLR8/BLOC1S2/GGA2/VPS26A/SLC11A2/SLC15A4/MFSD8/VAMP7/MANBA	1.31348122877994
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/251	75/9376	1.99224435590969	BIRC2/BBC3/MDM2/BID	1.43083814348343
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/251	133/9376	1.68516909804391	MDM2/EP300/STAT3/PLK2/GRB2/PLK3	1.31984573654112
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/251	77/9376	1.94049774926269	RB1/MDM2/STAT5A/GRB2	1.37433011055097
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/251	106/9376	1.7620085694956	RB1/MDM2/EP300/GRB2/HSP90AA1	1.30851583719371
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/251	78/9376	1.91561957299009	NLRP3/TICAM2/CASP7/TLR4	1.34670868435958
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/251	28/9376	2.6681844052362	ATP6V1C1/CA2	1.46612089439002
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/251	29/9376	2.57617804643495	SAV1/MOB1A	1.40985423814292
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/251	56/9376	2.00113830392715	CSNK1G2/CSNK1G3/SPOPL	1.24619555445124
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/251	144/9376	1.55644090305445	ADIPOR2/TRAF3/TBK1/CXCL1/C3AR1/TLR4	1.11598525699752
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/251	59/9376	1.89938550881221	DCK/CMPK2/NT5C3A	1.14931720027489
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/251	120/9376	1.55644090305445	MAP3K1/PRKCD/RIPK2/GRB2/NFKBIE	1.01742887567648
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/251	217/9376	1.37712743496062	PTGES3/RB1/STAT3/AHR/STAT5A/VDR/GRB2/HSP90AA1	0.93218052839952
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/251	122/9376	1.53092547841421	PFKFB3/ADIPOR2/RAB10/PFKFB4/RAB8A	0.97893712112947
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/251	62/9376	1.80747975838581	HSPA1A/ATG5/HSPA1B	1.05795071089724
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/251	63/9376	1.7787896034908	SETD2/EZH2/ASH1L	1.02861222330437
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/251	95/9376	1.57282449150765	ATP6V1C1/CXCL1/ICAM1/TLR4	0.930662161600346
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/251	66/9376	1.69793553060485	IFNGR2/STAT3/TLR4	0.943666412499584
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/251	193/9376	1.35482938711475	GNG5/PRKCD/CCR1/CCR2/STAT3/GRB2/CXCL1	0.826060785229135
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/251	99/9376	1.50927602720431	DEFB1/PTAFR/ICAM1/C3AR1	0.844837367803325
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/251	68/9376	1.64799625029295	STAT3/STAT5A/GRB2	0.889415767254675
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/251	100/9376	1.49418326693227	TNFRSF10D/CCR1/CCR2/CXCL1	0.823974418278306
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/251	368/9376	1.21808418499913	HSPA5/NXF1/DDIT3/TBK1/EIF2S1/BID/GLE1/RAB8A/NUP98/NUP54/NXT1/TANK	0.707847912397436
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/251	133/9376	1.40430758170326	IFNGR2/LAT2/GRB2/BID/ICAM1	0.778820351772638
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/251	101/9376	1.47938937320027	PRKCD/STAT3/STAT5A/ICAM1	0.803337781808776
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/251	70/9376	1.60091064314172	HIF1A/EP300/GRB2	0.836919052017687
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/251	70/9376	1.60091064314172	EIF4G3/BID/ICAM1	0.836919052017687
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/251	102/9376	1.46488555581595	ATP2A2/KCNMA1/CA2/RAB8A	0.782922285396015
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/251	201/9376	1.30090582941864	BIRC2/MDM2/FLI1/DDIT3/ID2/KDM6A/CEBPB	0.71520683462167
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/251	71/9376	1.57836260591437	ATP6V1C1/ADAM17/CXCL1	0.81129211273157
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/251	103/9376	1.45066336595366	NXF1/ACIN1/GLE1/NXT1	0.762722926454482
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/251	103/9376	1.45066336595366	CD1D/GNA15/CXCL1/TLR4	0.762722926454482
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/251	41/9376	1.82217471577106	RB1/MDM2	0.874993741004783
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/251	104/9376	1.43671467974257	ETNK1/SAMD8/GPCPD1/MBOAT7	0.74273486556051
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/251	105/9376	1.42303168279264	HIF1A/OPA1/TBK1/EIF2S1	0.72295341957705
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/251	105/9376	1.42303168279264	PRKCD/NLRP3/MDM2/PLK3	0.72295341957705
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/251	205/9376	1.27552230103974	RB1/MDM2/TRAF3/EP300/STAT3/STAT5A/GRB2	0.661502367727162
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/251	138/9376	1.35342687222126	NLRP3/PKN2/NLRC4/TBK1/TLR4	0.693675241287197
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/251	75/9376	1.49418326693227	BBC3/MDM2/BID	0.712623119483184
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/251	76/9376	1.47452296078843	RB1/MDM2/GRB2	0.68885627005089
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/251	109/9376	1.37081033663511	PRKCD/STAT3/SOCS3/PPP1R3B	0.645805235933864
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/251	77/9376	1.45537331194702	RB1/STAT3/BRCA2	0.665427700003251
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/251	45/9376	1.66020362992475	DEFB1/ABCA1	0.736251397908918
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/251	78/9376	1.43671467974257	IFNGR2/NCF2/TLR4	0.642327303987192
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/251	214/9376	1.22187883978106	GNG5/CGAS/LIMK2/TBK1/BID/TRIM5/TLR4	0.544544895772259
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/251	46/9376	1.62411224666551	ALAS1/BLVRA	0.703731289154233
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/251	148/9376	1.26197911058469	RB1/FRAT2/FZD2/BRCA2/GRB2	0.532782302680481
Genetic Information Processing	Translation	hsa03010	Ribosome	7/251	222/9376	1.17784716987904	MRPL18/MRPS18C/MRPL42/RPS10/RPL36A/MRPL47/MRPS35	0.444758292372279
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/251	18/9376	2.07525453740593	ACSL1	0.757289749552967
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/251	18/9376	2.07525453740593	MANBA	0.757289749552967
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/251	18/9376	2.07525453740593	MMADHC	0.757289749552967
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/251	50/9376	1.49418326693227	ICAM1/TLR4	0.581073935222818
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/251	154/9376	1.21281109328918	ALAS1/CMPK2/BCAT1/GCH1/MTHFD2	0.441619383065254
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/251	85/9376	1.31839700023436	DCK/CMPK2/NT5C3A	0.489049999266029
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/251	333/9376	1.12175920940861	MX1/ATP6V1C1/RB1/OASL/MDM2/TRAF3/EP300/FZD2/GRB2/TBK1	0.375209420005614
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/251	52/9376	1.43671467974257	MYLIP/ABCA1	0.523726310709396
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/251	300/9376	1.1206374501992	MAP3K1/MKNK1/DDIT3/MAP3K8/HSPA1A/GRB2/PPM1B/DUSP2/HSPA1B	0.352209929536912
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/251	122/9376	1.22474038273137	HIF1A/MDM2/EP300/ATP2A2	0.414383396949995
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/251	20/9376	1.86772908366534	NPL	0.644258426523981
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/251	21/9376	1.7787896034908	CSGALNACT2	0.592534932620685
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/251	21/9376	1.7787896034908	BCAT1	0.592534932620685
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/251	235/9376	1.11268966686446	COA6/KDM1A/ACSL1/GRB2/COX19/KDM3B/COA4	0.290153112779607
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/251	57/9376	1.31068707625638	ACSL1/HACD4	0.390195289752189
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/251	93/9376	1.20498650559054	PDCD10/SNAI1/EP300	0.329479678476314
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/251	93/9376	1.20498650559054	IFNGR2/STAT5A/NFKBIE	0.329479678476314
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/251	93/9376	1.20498650559054	MAP3K1/PRKCD/GRB2	0.329479678476314
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/251	93/9376	1.20498650559054	RB1/BIRC2/TRAF3	0.329479678476314
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/251	275/9376	1.08667873958711	STIP1/HSPA5/PRKCD/DDIT3/NCF2/HSPA1A/EIF2S1/HSPA1B	0.241958252725937
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/251	23/9376	1.62411224666551	GLS	0.497000948813576
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/251	23/9376	1.62411224666551	PDSS1	0.497000948813576
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/251	204/9376	1.09866416686196	HIF1A/MDM2/STAT3/FZD2/GRB2/TLR4	0.236291759411991
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/251	59/9376	1.26625700587481	LAP3/GSR	0.34024759521615
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/251	243/9376	1.07605790828456	ACIN1/HSPA1A/LSM6/LSM2/HSPA1B/SF3B6/U2SURP	0.199226381841749
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/251	170/9376	1.09866416686196	MAP3K1/RAP2C/CD1D/RAB8B/RAB8A	0.215305186037176
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/251	170/9376	1.09866416686196	RB1/FRAT2/FZD2/GRB2/ARID2	0.215305186037176
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/251	61/9376	1.22474038273137	VDR/SLC11A2	0.292052323943637
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/251	98/9376	1.14350760224408	INPPL1/PRKCD/LIMK2	0.236846419844299
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/251	99/9376	1.13195702040324	RB1/MDM2/GRB2	0.218903336944062
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/251	99/9376	1.13195702040324	HIF1A/GRB2/GPCPD1	0.218903336944062
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/251	26/9376	1.43671467974257	SLC19A2	0.369815169421242
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/251	27/9376	1.38350302493729	HACD4	0.330958971626375
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/251	178/9376	1.04928600205918	CACYBP/FRAT2/EP300/TLE4/FZD2	0.110101428002761
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/251	103/9376	1.08799752446525	IFNGR2/GNA15/TLR4	0.148930963666977
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/251	480/9376	1.01168658698539	HSPA5/FRAT2/HIP1/DDIT3/ATP2A2/FZD2/TBK1/CASP7/EIF2S1/BID/RAB8A/PPID/TANK	0.0435930233277265
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/251	28/9376	1.3340922026181	HACD4	0.293624348347644
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/251	28/9376	1.3340922026181	GCH1	0.293624348347644
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/251	144/9376	1.03762726870297	ID2/STAT3/FZD2/GRB2	0.0754643968534517
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/251	69/9376	1.08274149777701	ALOX5AP/GRB2	0.11440608625347
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/251	69/9376	1.08274149777701	PTGER2/KCNMA1	0.11440608625347
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/251	30/9376	1.24515272244356	GART	0.223043988133507
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	6/251	224/9376	1.00056915196357	MAP3K1/RB1/EP300/STAT5A/ETS2/ICAM1	0.00142988234644352
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/251	31/9376	1.20498650559054	DERA	0.189593100357972
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/251	31/9376	1.20498650559054	HSPA5	0.189593100357972
NA	NA	hsa04981	Folate transport and metabolism	1/251	31/9376	1.20498650559054	MTHFS	0.189593100357972
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/251	150/9376	0.996122177954847	RB1/FRAT2/FZD2/GRB2	-0.00794022560204786
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/251	32/9376	1.16733067729084	HK2	0.157249837588963
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/251	32/9376	1.16733067729084	ATG5	0.157249837588963
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/251	73/9376	1.02341319652895	RB1/MDM2	0.033305556338514
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/251	33/9376	1.13195702040324	BCAT1	0.125936714343375
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	10/251	388/9376	0.962746950342958	ADAM17/FRAT2/DDIT3/ATP2A2/FZD2/SLC11A2/CASP7/EIF2S1/BID/PPID	-0.124294589570489
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/251	155/9376	0.963989204472433	ATP6V1C1/NCF2/SEC22B/TLR4	-0.0749748518182779
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/251	75/9376	0.996122177954847	HSPA5/GSR	-0.00559190451706689
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/251	34/9376	1.09866416686196	POLR3K	0.0955839651099083
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/251	34/9376	1.09866416686196	NFIL3	0.0955839651099083
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/251	76/9376	0.983015307192283	PLIN2/ACSL1	-0.0246563667141502
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/251	76/9376	0.983015307192283	HRH2/CA2	-0.0246563667141502
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/251	157/9376	0.951709087218007	RB1/NBN/MDM2/PPID	-0.101199739711864
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/251	158/9376	0.94568561198245	ATP6V1C1/FZD2/GRB2/DDIT4	-0.11419080760698
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/251	36/9376	1.03762726870297	HK2	0.0375134122256027
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/251	200/9376	0.933864541832669	CYFIP1/NAIP/NLRP3/CASP7/TLR4	-0.156793741754861
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/251	37/9376	1.00958328846775	GLS	0.00968659847268959
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/251	37/9376	1.00958328846775	HK2	0.00968659847268959
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/251	37/9376	1.00958328846775	ICAM1	0.00968659847268959
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/251	80/9376	0.933864541832669	STAT3/GRB2	-0.0985229404236682
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/251	362/9376	0.928705069225859	GNG5/MDM2/PKN2/PIK3AP1/GRB2/LPAR6/DDIT4/TLR4/HSP90AA1	-0.229435292029453
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/251	122/9376	0.918555287048527	MAP3K8/GRB2/NFKBIE	-0.150170327229481
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/251	38/9376	0.983015307192283	HK2	-0.0173991736413096
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/251	38/9376	0.983015307192283	RFXANK	-0.0173991736413096
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/251	83/9376	0.900110401766428	AGPS/ACSL1	-0.15159588276949
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/251	41/9376	0.911087357885531	ALAS1	-0.0946246629262945
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/251	86/9376	0.868711201704809	STAT5A/GRB2	-0.202850043040247
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/251	130/9376	0.862028807845541	GNG5/GRB2/GNA15	-0.262717625891778
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/251	87/9376	0.858726015478317	BBC3/GRB2	-0.219555035200075
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/251	43/9376	0.868711201704809	ACSL1	-0.143105831173177
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/251	43/9376	0.868711201704809	ABCA1	-0.143105831173177
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/251	89/9376	0.839428801647343	GNG5/GLS	-0.252424201706702
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/251	44/9376	0.848967765302427	PARP4	-0.166538513502475
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/251	44/9376	0.848967765302427	HSPD1	-0.166538513502475
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/251	90/9376	0.830101814962373	ADIPOR2/ATG5	-0.268597345878111
NA	NA	hsa04081	Hormone signaling	5/251	219/9376	0.852844330440794	GNG5/ADIPOR2/STAT3/STAT5A/GNA15	-0.365450459093065
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/251	48/9376	0.778220451527224	BCAT1	-0.255478235105361
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/251	48/9376	0.778220451527224	HK2	-0.255478235105361
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/251	227/9376	0.82278814258385	PRKCD/HIF1A/NCF2/AHR/GRB2	-0.448254806184147
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/251	142/9376	0.789181302957185	NCF2/ICAM1/HSP90AA1	-0.419821256701212
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/251	50/9376	0.747091633466135	LAP3	-0.297376438309775
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/251	99/9376	0.754638013602157	PRKCD/PTGER2	-0.407030693915202
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/251	51/9376	0.732442777907976	AGPS	-0.317748426384769
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/251	51/9376	0.732442777907976	ATP6V1C1	-0.317748426384769
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/251	101/9376	0.739694686600134	EP300/FZD2	-0.436207193463023
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/251	53/9376	0.704803427798241	VDR	-0.357418859973255
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/251	323/9376	0.809542017687763	MDM2/EP300/STAT3/GRB2/GLS/DDIT4/EZH2	-0.57771047541053
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/251	238/9376	0.784760119187117	RGL1/GNG5/GRB2/ETS2/TBK1	-0.557816950249465
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/251	54/9376	0.691751512468644	BCAT1	-0.376746604921984
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/251	54/9376	0.691751512468644	BRCA2	-0.376746604921984
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/251	195/9376	0.766247829196036	TLR8/SIGLEC9/NCF2/TLR4	-0.547058823459549
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/251	55/9376	0.679174212241941	SAMD8	-0.395754099645138
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/251	155/9376	0.722991903354325	RB1/AHR/FZD2	-0.576733745928322
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/251	110/9376	0.679174212241941	ID2/EP300	-0.561339400298707
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/251	110/9376	0.679174212241941	CPEB2/HSP90AA1	-0.561339400298707
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/251	59/9376	0.633128502937403	GRB2	-0.468822009842593
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/251	158/9376	0.709264208986838	RB1/MDM2/EP300	-0.611244202278775
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/251	205/9376	0.728869886308425	PRKCD/NCF2/ATP2A2/GSR	-0.650957151171732
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/251	254/9376	0.735326410891866	P2RX4/HRH2/ATP2A2/GNA15/PTAFR	-0.70923227925673
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/251	63/9376	0.592929867830266	PTGES3	-0.537651391101113
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/251	63/9376	0.592929867830266	FZD2	-0.537651391101113
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/251	116/9376	0.644044511608738	NCF2/ICAM1	-0.639772041609044
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/251	116/9376	0.644044511608738	GNG5/GLS	-0.639772041609044
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/251	67/9376	0.557531069750847	HK2	-0.602802061580368
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/251	67/9376	0.557531069750847	EP300	-0.602802061580368
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/251	125/9376	0.597673306772908	BID/NSMAF	-0.751009751469463
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/251	226/9376	0.661143038465607	PTGER2/EP300/ATP2A2/FFAR2	-0.855196957641394
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/251	128/9376	0.583665338645418	DCK/GART	-0.786556103848546
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/251	75/9376	0.498061088977424	BCAT1	-0.723806928517318
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/251	183/9376	0.612370191365685	NXF1/NMD3/NXT1	-0.878254015213219
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/251	134/9376	0.557531069750847	PRKCD/KCNMA1	-0.855575342535361
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/251	78/9376	0.478904893247523	INPPL1	-0.766435456757583
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/251	79/9376	0.472842805991225	ATP6V1C1	-0.780348015332836
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/251	82/9376	0.455543678942766	TPMT	-0.821248706928132
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/251	144/9376	0.518813634351483	OPA1/ATP2A2	-0.965056463290612
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/251	86/9376	0.434355600852404	KCNMA1	-0.873958724601768
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/251	86/9376	0.434355600852404	ATP2A2	-0.873958724601768
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5/251	298/9376	0.626754726062194	IFNGR2/TNFRSF10D/CCR1/CCR2/CXCL1	-1.0859589841055
NA	NA	hsa04082	Neuroactive ligand signaling	3/251	199/9376	0.563134397085027	P2RX4/GNG5/HRH2	-1.03307079966987
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/251	87/9376	0.429363007739158	ATP2A2	-0.886831537642831
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/251	88/9376	0.424483882651213	C3AR1	-0.899588273622769
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/251	89/9376	0.419714400823672	GRB2	-0.912231649490934
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/251	149/9376	0.501403780849755	GRB2/LPAR6	-1.01746134159067
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/251	90/9376	0.415050907481186	CA2	-0.92476428567831
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/251	91/9376	0.410489908497877	GNG5	-0.937188710622808
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/251	93/9376	0.40166216853018	KCNMA1	-0.961722605909859
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/251	97/9376	0.385098780137183	GNG5	-1.00959385089325
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/251	98/9376	0.381169200748028	INPPL1	-1.02132470336259
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/251	160/9376	0.466932270916335	SIGLEC1/ICAM1	-1.1279171823424
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/251	268/9376	0.557531069750847	HSPA5/DDIT3/SLC11A2/EIF2S1	-1.21883447201333
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/251	99/9376	0.377319006801079	ATP2A2	-1.03296472477446
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/251	100/9376	0.373545816733068	CD1D	-1.04451578144212
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/251	370/9376	0.60574997308065	P2RX4/HRH2/PTGER2/PTAFR/C3AR1/LPAR6	-1.28325417163548
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/251	166/9376	0.450055200883214	ATP2A2/KCNMA1	-1.1856305754995
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/251	105/9376	0.35575792069816	ATP2A2	-1.10099794699065
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/251	107/9376	0.349108239937446	EP300	-1.12302722242725
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/251	232/9376	0.483033383706553	CYFIP1/LIMK2/SSH2	-1.32234398803316
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/251	115/9376	0.324822449333102	GNG5	-1.20821447427537
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/251	115/9376	0.324822449333102	GNG5	-1.20821447427537
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/251	115/9376	0.324822449333102	VDR	-1.20821447427537
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/251	116/9376	0.322022255804369	HK2	-1.21855462189913
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/251	117/9376	0.319269928831682	ARID2	-1.2288302311247
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/251	184/9376	0.406028061666378	LIMK2/SSH2	-1.34950933685319
NA	NA	hsa04519	Cadherin signaling	6/251	404/9376	0.554771014950101	FMN1/CYFIP1/SAV1/MOB1A/EP300/FZD2	-1.51717452653259
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/251	191/9376	0.391147452076511	GNG5/GRB2	-1.40992266974533
Organismal Systems	Immune system	hsa04611	Platelet activation	1/251	126/9376	0.296464933915133	SNAP23	-1.31857918975057
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/251	133/9376	0.280861516340652	GNG5	-1.3852811873013
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/251	203/9376	0.368025435204993	BIRC2/GRB2	-1.50972547747691
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/251	138/9376	0.270685374444252	ATP6V1C1	-1.4314347284265
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/251	138/9376	0.270685374444252	CPEB2	-1.4314347284265
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/251	140/9376	0.26681844052362	GNG5	-1.44957153223227
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/251	149/9376	0.250701890424878	GNG5	-1.52905664049956
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/251	154/9376	0.242562218657836	ATP2A2	-1.57181282487047
NA	NA	hsa04518	Integrin signaling	1/251	154/9376	0.242562218657836	ICAM1	-1.57181282487047
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/251	154/9376	0.242562218657836	TRPM2	-1.57181282487047
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/251	233/9376	0.320640186036968	LMNB1/TMOD3	-1.74156431187028
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/251	308/9376	0.363843327986754	BBC3/HIP1/EP300	-1.88273740651269
NA	NA	hsa04517	IgSF CAM signaling	2/251	299/9376	0.249863422563925	GRB2/ICAM1	-2.18630542008209