category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/156	138/9376	6.53288740245262	LCP2/CXCL8/TLR4/SKAP2/FCGR2A/FYB1/ACTB/RAC2/ACTR3/FOS/IL1B/NFKBIA/ARPC5/RHOG/MAP2K6	8.51696521001497
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/156	142/9376	6.34886240520043	FCGR3B/LCP2/LILRA5/FCGR2A/NCF2/FOS/STAT1/IL1B/LILRB3/NFKBIA/SPI1/SIRPA/IFNGR1/PLCG2/MAP2K6	8.35397440101858
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/156	196/9376	5.21297749869178	HIF1A/EIF2AK2/CXCL8/ICAM1/MAP1LC3B/LYN/CCR1/GNG5/HCK/FOS/STAT1/STAT3/GNG10/NFKBIA/IFNGR1/PLCG2/MAP2K6	7.75315223474793
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/156	78/9376	8.47600262984878	FCGR3B/TLR4/FCGR2A/NCF2/TLR2/FOS/STAT1/IL1B/NFKBIA/IFNGR1/CR1	8.62391471067508
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/156	98/9376	7.35949764521193	FCGR3B/PTPRC/LYN/FCGR2A/RAC2/ACTR3/HCK/MARCKS/PAK1/ARPC5/PLCG2/VASP	8.23173046030755
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/156	248/9376	4.36228287841191	CXCL8/CASP4/PTPRC/NAIP/TLR4/ACTB/LY96/TLR2/ACTR3/RHOH/FOS/IL1B/PAK1/NFKBIA/ARPC5/RHOG/SNX18/MAP2K6	6.97998919966678
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/156	105/9376	6.86886446886447	BCL2A1/CXCL8/ICAM1/LYN/TNFSF13B/TLR4/LY96/IL1B/TNFAIP3/TRIM25/NFKBIA/PLCG2	7.86625310544725
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/156	173/9376	5.21120497999111	MX1/MX2/RSAD2/EIF2AK2/CXCL8/ICAM1/TLR4/ADAR/ACTB/STAT1/IL1B/PML/TRIM25/NFKBIA/IFNGR1	7.27188828832006
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/156	56/9376	9.65934065934066	CXCL8/NAIP/TLR4/TLR2/IL1B/NFKBIA/SEC22B/CR1/RAB1A	8.45382706245818
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/156	193/9376	4.67118373854125	CXCL8/LYN/CCR1/ARRB2/RAC2/GNG5/HCK/STAT1/CXCR2/PAK1/STAT3/GNG10/NFKBIA/FOXO3/PLCG2	6.70308860526647
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/156	90/9376	6.67806267806268	HIF1A/PTEN/TLR4/TLR2/FOS/STAT1/STAT3/NFKBIA/IFNGR1/MAP2K6	7.04027420081514
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/156	136/9376	5.30316742081448	MX1/MX2/EIF2AK2/TLR4/ADAR/TLR2/FOS/STAT1/IL1B/TNFAIP3/STAT3/NFKBIA	6.57512765014803
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	15/156	238/9376	3.7879767291532	MX1/MX2/EIF2AK2/CXCL8/TLR4/ADAR/FCGR2A/TLR2/FOS/STAT1/IL1B/STAT3/NFKBIA/ISG15/PLCG2	5.66675612834031
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/156	66/9376	7.28515928515929	TLR4/TLR2/IL18R1/STAT1/IL1B/STAT3/IL18RAP/IFNGR1	6.66493460625718
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/156	216/9376	3.89553656220323	CXCL8/ICAM1/LYN/TLR4/NFE2L2/SOD2/NCF2/LY96/TLR2/FOS/IL1B/STAT3/NFKBIA/MAP2K6	5.60003406428718
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/156	91/9376	5.94420963651733	LYN/LILRA5/RAC2/PIK3AP1/FOS/LILRB3/NFKBIA/IFITM1/PLCG2	6.16465952867156
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/156	200/9376	3.90666666666667	CXCL8/CASP4/NAIP/TLR4/FCGR2A/ACTB/ACTR3/FOS/IL1B/PAK1/NFKBIA/ARPC5/RAB1A	5.40463043386788
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/156	187/9376	3.85684903331962	NAMPT/IFI16/CXCL8/CASP4/CARD16/MAP1LC3B/NAIP/TLR4/STAT1/IL1B/TNFAIP3/NFKBIA	5.13282485855923
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/156	109/9376	4.96259703599153	CXCL8/TLR4/LY96/TLR2/FOS/STAT1/IL1B/NFKBIA/MAP2K6	5.41260151370597
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/156	195/9376	3.69861932938856	FCGR3B/FPR2/CASP4/AQP9/TLR4/FCGR2A/ACTB/NCF2/TLR2/RAC2/PLCG2/CR1	4.95332034121764
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/156	142/9376	4.23257493680029	ICAM1/NFE2L2/ACTB/NCF2/RAC2/FOS/IL1B/IL1R2/DUSP1/MAP2K6	5.04870872078302
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/156	69/9376	6.09736157562245	FCER1G/LCP2/ALOX5AP/LYN/RAC2/PLCG2/MAP2K6	5.52773998149233
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	12/156	205/9376	3.51819887429644	EIF2AK2/ICAM1/LYN/B2M/TLR2/STAT1/TNFAIP3/STAT3/NFKBIA/ISG15/PLCG2/MAP2K6	4.74177656684067
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/156	119/9376	4.54557207498384	ICAM1/IRF1/IL18R1/FOS/IL1B/TNFAIP3/CEBPB/NFKBIA/MAP2K6	5.06299086604945
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/156	94/9376	5.11511183851609	S100A8/CXCL8/FOS/IL1B/TNFAIP3/CEBPB/NFKBIA/S100A9	5.21563588058253
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/156	50/9376	7.21230769230769	CXCL8/ICAM1/TLR4/TLR2/IL1B/CR1	5.72891965337424
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/156	71/9376	5.9256049115204	CXCL8/LYN/CXCR2/PAK1/ATP6V1C1/NFKBIA/PLCG2	5.41892370060082
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/156	95/9376	5.0612685560054	CXCL8/ICAM1/TNFSF13B/TLR4/TLR2/FOS/IL1B/ATP6V1C1	5.17497911968606
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/156	72/9376	5.84330484330484	CXCL8/ADAR/DDX3X/TRIM25/NFKBIA/ISG15/ZNFX1	5.3660619119373
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/156	214/9376	3.37023723939612	TLR4/B2M/TLR2/RAC2/GNG5/FOS/PAK1/GNG10/NFKBIA/APOBEC3A/PLCG2/MAP2K6	4.56232308471819
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/156	253/9376	3.08827404479578	UBE2D1/CXCL8/CASP4/MAP1LC3B/NAIP/TLR4/ACTB/ACTR3/IL1B/NFKBIA/FOXO3/ARPC5/PLCG2	4.37987171819242
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/156	109/9376	4.41119736532581	HIF1A/FOS/STAT1/IL1B/STAT3/IL1RAP/NFKBIA/IFNGR1	4.65943214902049
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/156	168/9376	3.57753357753358	FTH1/EIF2AK2/GLUL/TLR4/ZBP1/STAT1/IL1B/TNFAIP3/STAT3/IFNGR1	4.38489091764396
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/156	112/9376	4.29304029304029	TLR4/LY96/TLR2/STAT1/STAT3/NFKBIA/IFNGR1/MAP2K6	4.56025638075956
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/156	180/9376	3.33903133903134	EIF2AK2/B2M/TLR2/ZC3HAV1/STAT1/IL1B/PML/NFKBIA/IFNGR1/SP100	4.12149985363623
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/156	181/9376	3.32058365207536	FCGR3B/FCER1G/TLR4/FCGR2A/TLR2/STAT1/IL1B/CEBPB/IFNGR1/CR1	4.10055957494594
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/156	71/9376	5.07908992416035	IRF1/FOS/STAT1/STAT3/CISH/FOXO3	4.48762689334162
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/156	298/9376	2.62192393736018	IL1RN/CSF3R/CXCL8/TNFSF13B/CCR1/CSF2RB/IL18R1/CXCR2/IL1B/IL18RAP/IL1RAP/IL1R2/IFNGR1	3.70105895499516
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	11/156	227/9376	2.91245905342822	CXCL8/CCR1/B2M/RAC2/GNG5/CXCR2/IL1B/STAT3/GNG10/NFKBIA/MAP2K6	3.79402979505933
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/156	163/9376	3.31854648419066	CXCL8/TLR4/TLR2/DDX3X/FOS/STAT1/STAT3/NFKBIA/MAP2K6	3.88411026867071
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/156	103/9376	4.08464027881504	CXCL8/TLR4/TLR2/FOS/IL1B/NFKBIA/IFNGR1	4.09444917533839
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/156	133/9376	3.61519182571814	FCGR3B/FCER1G/LCP2/ICAM1/RAC2/PAK1/IFNGR1/PLCG2	3.95098490941988
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/156	105/9376	4.00683760683761	FCER1G/IRF1/STAT1/IL1B/PAK1/NFKBIA/PLCG2	4.03017411423343
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/156	78/9376	4.6232741617357	CXCL8/IRF1/TLR4/LY96/FOS/IL1B	4.17961427935365
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/156	110/9376	3.82470862470862	HIF1A/TLR4/PFKFB3/STAT3/MKNK1/IFNGR1/PLCG2	3.87620134106863
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/156	116/9376	3.62687886825818	ICAM1/ACTB/NCF2/RAC2/RHOH/PLCG2/VASP	3.7029344571721
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/156	155/9376	3.10206782464847	FCGR3B/TLR4/FCGR2A/ACTB/NCF2/TLR2/ATP6V1C1/SEC22B	3.43246438440846
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/156	156/9376	3.08218277449047	MX1/IFIT1/MX2/RSAD2/EIF2AK2/STAT1/STAT3/NFKBIA	3.41112916664967
Organismal Systems	Immune system	hsa04611	Platelet activation	7/156	126/9376	3.33903133903134	FCER1G/LCP2/LYN/FCGR2A/ACTB/PLCG2/VASP	3.43821415287252
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/156	42/9376	5.72405372405372	FTH1/SAT1/ACSL1/MAP1LC3B	3.99105811511581
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/156	101/9376	3.57044935262757	CXCL8/ICAM1/STAT1/IL1B/STAT3/PLCG2	3.37827699407981
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/156	133/9376	3.16329284750337	PTEN/SOD2/BCL6/STAT3/CDKN2D/FOXO3/IRS2	3.26826403749358
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/156	137/9376	3.0709339322478	BCL2A1/LMNB1/ACTB/CSF2RB/FOS/MCL1/NFKBIA	3.17611720923476
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/156	144/9376	2.92165242165242	CXCL8/TLR4/LY96/IL1B/NFKBIA/FOXO3/MAP2K6	3.0226694910102
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/156	300/9376	2.20376068376068	ARRB2/RAC2/FOS/IL1B/PAK1/MKNK1/IL1RAP/DUSP1/RASA2/MAP2K6/MAP4K4	2.75636048490542
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/156	83/9376	3.62063639172073	IFI16/ADAR/ZBP1/IL1B/NFKBIA	3.11925099335926
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/156	122/9376	2.95586380832282	FOS/STAT1/STAT3/IRS2/PLCG2/MAP2K6	2.82837021482981
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/156	201/9376	2.39214185482842	BCL2A1/CXCL8/NFKBIZ/BCL6/PML/CEBPB/SPI1/IL1R2	2.59514100482544
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/156	204/9376	2.35696329813977	HIF1A/TLR4/ACTB/TLR2/PAK1/STAT3/PLAUR/PLCG2	2.54878756110222
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/156	168/9376	2.5042735042735	CSF3R/CSF2RB/STAT1/STAT3/MCL1/CISH/IFNGR1	2.55906471366052
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/156	169/9376	2.48945531785769	HIF1A/PTEN/MAP1LC3B/VMP1/SH3GLB1/IRS2/RAB1A	2.54152412739074
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/156	100/9376	3.00512820512821	CXCL8/CCR1/IL18R1/CXCR2/IL18RAP	2.62206982650769
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/156	100/9376	3.00512820512821	CSF3R/CD55/IL1B/IL1R2/CR1	2.62206982650769
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/156	68/9376	3.53544494720965	BCL2A1/STAT3/PML/SPI1	2.72937325077355
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/156	103/9376	2.9176001991536	CXCL8/TLR4/TLR2/IL1B/IL1R2	2.54535888932545
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/156	70/9376	3.43443223443223	ACSL1/STAT3/NFKBIA/IRS2	2.65917955255292
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/156	70/9376	3.43443223443223	CD55/ICAM1/ACTB/RAC2	2.65917955255292
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/156	224/9376	2.14652014652015	PTEN/ETS2/ICAM1/B2M/FOS/NFKBIA/SPI1/IL1R2	2.25907250999408
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/156	109/9376	2.75699835332863	PTEN/STAT3/NFKBIA/IRS2/PPP1R3B	2.39992405496408
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/156	227/9376	2.11815203885688	HIF1A/PTEN/NFE2L2/SOD2/NCF2/FOS/NFKBIA/FOXO3	2.21824469560524
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/156	78/9376	3.08218277449047	ACTB/ACTR3/ARPC5/RHOG	2.40189410682508
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/156	80/9376	3.00512820512821	PTEN/STAT3/FOXO3/PLCG2	2.34272633122184
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/156	120/9376	2.5042735042735	NFKBIA/FOXO3/PLCG2/PSEN1/IRAK3	2.15718917839555
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/156	333/9376	1.8048818048818	MX1/MX2/EIF2AK2/OASL/PTEN/IRF1/STAT1/ATP6V1C1/ISG15/PSEN1	1.94527245861757
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/156	122/9376	2.46321984026902	LCP2/PTPRC/FOS/PAK1/NFKBIA	2.11595889057008
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/156	51/9376	3.53544494720965	ACTB/ATP6V1C1/PLCG2	2.36155100362236
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/156	205/9376	2.05228267667292	EIF2AK2/LYN/DDX3X/STAT3/NFKBIA/SP100/RASA2	1.98145165930714
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/156	88/9376	2.73193473193473	CD55/SERPINA1/PLAUR/CR1	2.1232162584937
NA	NA	hsa04517	IgSF CAM signaling	9/156	299/9376	1.80910728067919	LCP2/ICAM1/LYN/ACTB/ACTR3/PAK1/IL1RAP/ARPC5/PLCG2	1.84949436493854
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/156	91/9376	2.64187094956326	PDE4B/ARRB2/GNG5/GNG10	2.04715741001705
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/156	130/9376	2.31163708086785	ARRB2/GNG5/FOS/GNG10/NFKBIA	1.95880360407995
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/156	93/9376	2.58505652054039	FOS/STAT1/NFKBIA/IFNGR1	1.99813362822976
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/156	99/9376	2.42838642838643	IL1B/IL1RAP/PLCG2/MAP2K6	1.8584120423943
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/156	99/9376	2.42838642838643	FCGR3B/FPR2/ICAM1/FCGR2A	1.8584120423943
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/156	99/9376	2.42838642838643	HIF1A/RAC2/FOS/GPCPD1	1.8584120423943
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/156	62/9376	2.90818858560794	SOD2/FOXO3/IRS2	1.96079187416229
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/156	105/9376	2.28962148962149	HIF1A/MAP1LC3B/USP15/FOXO3	1.72852671950514
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/156	238/9376	1.76772247360483	ETS2/RAC2/GNG5/PAK1/GNG10/PLCG2/RASA2	1.56044919122626
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/156	33/9376	3.64257964257964	STX11/SEC22B	1.97799121041271
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/156	73/9376	2.46996838777661	MX1/MX2/APOBEC3A	1.63998694773163
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/156	73/9376	2.46996838777661	STAT3/FOXO3/PLCG2	1.63998694773163
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/156	250/9376	1.6828717948718	ARRB2/ACTR3/CXCR2/SH3GLB1/PML/ARPC5/EHD4	1.4234801784177
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/156	37/9376	3.24878724878725	ICAM1/IL1B	1.78271336838309
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/156	77/9376	2.34165834165834	RAC2/STAT1/STAT3	1.53762931682321
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/156	212/9376	1.70101596516691	LCP2/FYB1/ACTB/RAC2/MAP2K6/VASP	1.34287557871535
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/156	122/9376	1.97057587221522	HIF1A/ACTB/STAT1/PLCG2	1.40354756631035
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/156	362/9376	1.49426264343391	CSF3R/PTEN/TLR4/TLR2/GNG5/PIK3AP1/MCL1/GNG10/FOXO3	1.24748626535523
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/156	170/9376	1.76772247360483	ACTB/ACTR3/RAB8B/ARPC5/VASP	1.31394052104371
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/156	226/9376	1.59564329475834	PDE4B/RAC2/FOS/PAK1/NFKBIA/FFAR2	1.17899620350658
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/156	133/9376	1.80759591285907	ARRB2/GNG5/FOS/GNG10	1.2201014217147
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/156	89/9376	2.02592912705272	GLUL/GNG5/GNG10	1.26490269359661
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/156	90/9376	2.0034188034188	SOD2/FOXO3/IRS2	1.24414680056553
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/156	138/9376	1.7421033073207	MKNK1/FLOT1/IRS2/PPP1R3B	1.14234532368862
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/156	97/9376	1.8588421887391	GNG5/FOS/GNG10	1.10593888112025
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/156	15/9376	4.00683760683761	ALPL	1.51592235386247
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/156	149/9376	1.61349165376011	FCER1G/CXCL8/CXCR2/PLCG2	0.981870042228868
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/156	17/9376	3.53544494720965	GLUL	1.36096325250483
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/156	203/9376	1.48035872173803	PTEN/ACTB/RAC2/PAK1/VASP	0.899995793364356
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/156	59/9376	2.03737505432421	ABHD5/IRS2	1.03969566996843
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/156	59/9376	2.03737505432421	PTEN/FOXO3	1.03969566996843
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/156	106/9376	1.70101596516691	PTEN/NFKBIA/IL1R2	0.944111855541663
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/156	18/9376	3.33903133903134	ACSL1	1.2920021894637
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/156	60/9376	2.0034188034188	RAC2/PLCG2	1.01420464970706
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/156	157/9376	1.53127551853667	CXCL8/PTEN/FOXO3/MAP2K6	0.873192907326771
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/156	157/9376	1.53127551853667	CXCL8/FOS/IL1B/IRS2	0.873192907326771
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/156	62/9376	1.93879239040529	DTX3L/PSEN1	0.964672205103684
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/156	323/9376	1.30253234897198	PTEN/MARCKS/STAT3/MCL1/IRS2/PLCG2/ZEB2	0.71971291702688
NA	NA	hsa04382	Cornified envelope formation	5/156	217/9376	1.38485170743235	S100A8/S100A11/S100A12/ABHD5/S100A9	0.746073701892098
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/156	21/9376	2.86202686202686	DSE	1.11110773312401
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/156	21/9376	2.86202686202686	VNN2	1.11110773312401
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/156	115/9376	1.56789297658863	GNG5/FOS/GNG10	0.797019510036643
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/156	115/9376	1.56789297658863	GNG5/GNG10/DUSP1	0.797019510036643
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/156	115/9376	1.56789297658863	PDE4B/ARRB2/FOS	0.797019510036643
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/156	116/9376	1.55437665782493	GLUL/GNG5/GNG10	0.781467487259141
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/156	170/9376	1.41417797888386	PTEN/NFE2L2/ACTB/PLCG2	0.708856713317493
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/156	23/9376	2.61315496098105	GLUL	1.00750454912469
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/156	23/9376	2.61315496098105	IDI1	1.00750454912469
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/156	70/9376	1.71721611721612	HIF1A/PAK1	0.783429666551102
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/156	71/9376	1.69302997472012	HIF1A/PTEN	0.762439664304786
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/156	122/9376	1.47793190416141	PFKFB3/FOXO3/IRS2	0.691136242050612
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/156	232/9376	1.29531388152078	ACTB/RAC2/ACTR3/PAK1/ARPC5	0.592437066036161
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/156	125/9376	1.44246153846154	FCER1G/PTEN/RAC2	0.647766774047632
NA	NA	hsa04519	Cadherin signaling	8/156	404/9376	1.19014978420919	ACTB/DSC2/RAC2/ACTR3/NFKBIA/ARPC5/PSEN1/VASP	0.508187951011359
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/156	76/9376	1.58164642375169	ACSL1/GK	0.662226965344863
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/156	76/9376	1.58164642375169	ACTB/KCNJ15	0.662226965344863
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/156	76/9376	1.58164642375169	PTEN/PLCG2	0.662226965344863
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/156	184/9376	1.30657748049052	RAC2/PAK1/PLCG2/PLXNC1	0.546294252406401
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/156	78/9376	1.54109138724523	PTEN/PLCG2	0.624173934296507
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/156	78/9376	1.54109138724523	PNPT1/BTG2	0.624173934296507
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/156	28/9376	2.14652014652015	B3GNT5	0.790285167910002
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/156	28/9376	2.14652014652015	ALPL	0.790285167910002
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/156	28/9376	2.14652014652015	ATP6V1C1	0.790285167910002
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/156	29/9376	2.07250221043325	PAK1	0.75239092803224
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/156	30/9376	2.0034188034188	IL1B	0.715999058165182
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/156	83/9376	1.44825455668829	ACSL1/SOD2	0.533541576254189
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/156	31/9376	1.93879239040529	GLUL	0.680993915428267
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/156	140/9376	1.28791208791209	MAP1LC3B/GNG5/GNG10	0.446441369359046
Human Diseases	Immune disease	hsa05310	Asthma	1/156	32/9376	1.87820512820513	FCER1G	0.647272297216901
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/156	86/9376	1.39773404889684	PAK1/PLCG2	0.481966238053972
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/156	86/9376	1.39773404889684	ACTB/DSC2	0.481966238053972
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/156	142/9376	1.26977248104009	UBE2D1/UBE2B/PML	0.421336768453236
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/156	87/9376	1.38166814028883	RAC2/FOS	0.46520409661079
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/156	34/9376	1.76772247360483	NFIL3	0.583319181630171
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/156	35/9376	1.71721611721612	PFKFB3	0.552929617504713
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/156	36/9376	1.66951566951567	GYG1	0.523505242216626
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/156	93/9376	1.2925282602702	ACTB/RAC2	0.368763224830715
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/156	93/9376	1.2925282602702	PTEN/NFKBIA	0.368763224830715
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/156	37/9376	1.62439362439362	GLUL	0.494984513070314
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/156	38/9376	1.58164642375169	NAMPT	0.467311428872456
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/156	38/9376	1.58164642375169	PTPRC	0.467311428872456
NA	NA	hsa04518	Integrin signaling	3/156	154/9376	1.17082917082917	ICAM1/ACTB/RAC2	0.278030417107697
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/156	157/9376	1.1484566389025	HIF1A/CEBPB/SIRPA	0.244000108441449
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/156	98/9376	1.22658294086866	PTEN/PLCG2	0.293288841381813
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/156	217/9376	1.10788136594588	ARRB2/FOS/BCL6/STAT3	0.209138867002605
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/156	99/9376	1.21419321419321	ACTB/TPM4	0.278677562839544
NA	NA	hsa04081	Hormone signaling	4/156	219/9376	1.09776372790071	GNG5/STAT3/GNG10/IRS2	0.190416983419281
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/156	41/9376	1.46591619762351	CXCL8	0.388888457424471
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/156	160/9376	1.12692307692308	SELL/ICAM1/PTPRC	0.210625925750364
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/156	43/9376	1.39773404889684	ACSL1	0.340015599998854
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/156	104/9376	1.15581854043393	PGS1/GPCPD1	0.207841164482009
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/156	44/9376	1.36596736596737	IL1B	0.316492782292021
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/156	105/9376	1.14481074481074	ACTB/TPM4	0.194095123019607
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/156	45/9376	1.33561253561254	IL1B	0.293536974084223
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/156	46/9376	1.30657748049052	FTH1	0.271119541640503
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/156	233/9376	1.0318036755805	LMNB1/ACTB/TPM4/DSC2	0.0639430565480828
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/156	47/9376	1.27877795962902	IRS2	0.249213918850673
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/156	174/9376	1.03625110521662	UBE2D1/NFE2L2/PPP1R15A	0.0627823023841333
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/156	50/9376	1.20205128205128	SAT1	0.186329399325528
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/156	50/9376	1.20205128205128	TNFSF13B	0.186329399325528
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/156	56/9376	1.07326007326007	ARRB2	0.0715213795470236
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/156	57/9376	1.05443094916779	ACSL1	0.0536143637404039
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/156	59/9376	1.0186875271621	CMPK2	0.0187293312981326
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/156	60/9376	1.0017094017094	LYN	0.00172777623459467
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/156	61/9376	0.985287936107608	FTH1	-0.0149944163955386
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/156	65/9376	0.92465483234714	GK	-0.0792859794242994
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/156	65/9376	0.92465483234714	ARRB2	-0.0792859794242994
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/156	205/9376	0.879549718574109	PTEN/NCF2/RAC2	-0.226808266719693
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/156	69/9376	0.871051653660349	FOS	-0.139835661848643
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/156	143/9376	0.840595302133764	FCGR3B/FCGR2A	-0.249850483542336
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/156	144/9376	0.834757834757835	SKIL/STAT3	-0.259918206788127
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/156	73/9376	0.823322795925536	PTEN	-0.19711193183011
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/156	148/9376	0.812196812196812	PTEN/FOS	-0.299545294274816
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/156	149/9376	0.806745826880055	GNG5/GNG10	-0.309295948786261
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/156	75/9376	0.801367521367521	GLUL	-0.224645926698315
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/156	75/9376	0.801367521367521	PTEN	-0.224645926698315
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/156	77/9376	0.780552780552781	NFKBIA	-0.251501047353312
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/156	154/9376	0.780552780552781	ALPL/CMPK2	-0.357157982210473
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/156	154/9376	0.780552780552781	ACTB/FOS	-0.357157982210473
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/156	79/9376	0.760791950665368	ATP6V1C1	-0.277715677173005
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/156	158/9376	0.760791950665368	PTEN/ATP6V1C1	-0.394428654393465
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/156	82/9376	0.732958098811757	B2M	-0.315912987278356
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/156	83/9376	0.724127278344146	UBE2D1	-0.328361562780835
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/156	85/9376	0.707088989441931	CMPK2	-0.352855106446835
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/156	166/9376	0.724127278344146	IRS2/VASP	-0.466461135622762
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/156	87/9376	0.690834070144415	TPM4	-0.376833279802872
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/156	90/9376	0.667806267806268	AQP9	-0.411889599505793
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/156	250/9376	0.721230769230769	LITAF/AP5B1/ATP6V1C1	-0.581108309543302
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/156	93/9376	0.646264130135098	MAP2K6	-0.445921976868809
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/156	178/9376	0.675309709017574	RAC2/PSEN1	-0.568872680523969
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/156	99/9376	0.607096607096607	FOS	-0.511189676937833
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/156	103/9376	0.583520039830719	ETF1	-0.552821682700438
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/156	191/9376	0.629346220969258	GNG5/GNG10	-0.673175051930693
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/156	194/9376	0.619614062913032	ACTB/TPM4	-0.696368552148414
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/156	275/9376	0.655664335664336	NCF2/RAC2/IL1B	-0.753852315926434
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/156	110/9376	0.546386946386946	SKIL	-0.622469698772038
NA	NA	hsa04082	Neuroactive ligand signaling	2/156	199/9376	0.604045870377529	GNG5/GNG10	-0.734350721704925
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/156	117/9376	0.513697129081745	ACTB	-0.688494062237898
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	4/156	368/9376	0.653288740245262	MAP1LC3B/ACTB/RAB1A/MAP2K6	-0.882592318704384
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/156	128/9376	0.469551282051282	PDE4B	-0.78597178376125
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/156	388/9376	0.619614062913032	EIF2AK2/IL1B/IRS2/PSEN1	-0.995385386380873
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/156	138/9376	0.435525826830175	ATP6V1C1	-0.868914645309473
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/156	139/9376	0.432392547500461	FOS	-0.876945278406475
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/156	235/9376	0.511511183851609	ACSL1/ACTB	-0.986447959059003
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/156	480/9376	0.626068376068376	MAP1LC3B/IL1B/RAB1A/PSEN1/MAP2K6	-1.0939510866913
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/156	154/9376	0.39027639027639	TPM4	-0.992346381528642
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/156	157/9376	0.382818879634166	ACTB	-1.01438548932919
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/156	158/9376	0.380395975332684	CDKN2D	-1.02166119570845
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	2/156	268/9376	0.448526597780329	NFE2L2/DUSP1	-1.19141464441999
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/156	183/9376	0.328429312035869	NOP10	-1.19335903049398
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/156	254/9376	0.236624268120331	PLCG2	-1.60432610629646
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/156	308/9376	0.195138195138195	SOD2	-1.86820012835538
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/156	370/9376	0.162439362439362	FPR2	-2.13812763323296
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/156	449/9376	0.133858717377648	ARRB2	-2.44647971244043