category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/137	216/9376	8.87158691538253	HSPA1A/HSP90AA1/CCL3/HSPA5/CCL3L1/HSPD1/IL18/ABCG1/CXCL8/SOD2/HSPA1B/CASP1/HSPA8/NCF1/OLR1/NCF2/CXCL3/TLR2/NLRP3/HSP90AB1/IL1B/IRF7/RAP1A/CYCS/CD36/CXCL1/CYBB/CALM1	14.2519691010621
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/137	82/9376	14.1883567740787	HSPA1A/HSP90AA1/HSPA5/HLA-DQB1/CTSB/B2M/HSPA1B/CTSL/IFI30/HLA-DQA1/CTSS/HSPA8/HLA-DPA1/HLA-DQA2/HSP90AB1/HLA-DPB1/HLA-DRB1	14.6059469056239
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/137	181/9376	7.94031536072912	FCER1G/HSPD1/FCGR3A/FCGR2A/IFNGR1/IL18/HLA-DQB1/HLA-DQA1/CTSS/HLA-DPA1/HLA-DQA2/CLEC7A/CTSD/CLEC4E/TLR2/RIPK2/IL1B/HLA-DPB1/CYCS/CALM1/HLA-DRB1	11.4809034223901
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/137	95/9376	11.5263926238955	CCL3/CCL3L1/IL18/HLA-DQB1/CXCL8/CTSL/HLA-DQA1/HLA-DPA1/HLA-DQA2/CXCL3/TLR2/CD80/IL1B/HLA-DPB1/CXCL1/HLA-DRB1	12.5567549603058
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/137	56/9376	15.8873826903024	HSPA1A/HSPD1/IL18/CXCL8/HSPA1B/CASP1/HSPA8/CXCL3/TLR2/IL1B/NAIP/CYCS/CXCL1	13.606231249659
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/137	78/9376	12.2837357289912	FCGR3A/FCGR2A/IFNGR1/HLA-DQB1/HLA-DQA1/NCF1/HLA-DPA1/HLA-DQA2/NCF2/TLR2/IL1B/HLA-DPB1/CYBB/HLA-DRB1	12.1853743232212
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/137	155/9376	7.9476336237344	FCGR3A/FCGR2A/MSR1/HLA-DQB1/CTSL/HLA-DQA1/CTSS/NCF1/OLR1/HLA-DPA1/HLA-DQA2/CLEC7A/NCF2/TLR2/HLA-DPB1/CD36/CYBB/HLA-DRB1	10.6205543219561
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/137	173/9376	6.72511708366736	IFNGR1/IL18/HLA-DQB1/CXCL8/MX1/CASP1/HLA-DQA1/HLA-DPA1/HLA-DQA2/NLRP3/IL1B/IRF7/HLA-DPB1/CYCS/DNAJB1/OAS1/HLA-DRB1	9.25499421404219
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/137	44/9376	13.9986728599867	HSPD1/HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/IL1B/HLA-DPB1/HLA-DRB1	10.5237718765168
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/137	187/9376	5.85565400679183	HSP90AA1/IL18/CTSB/CXCL8/CASP1/CXCL3/NAMPT/NLRP3/HSP90AB1/RIPK2/IL1B/IRF7/NAIP/CXCL1/CYBB/OAS1	8.16709954291658
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/137	66/9376	10.3693873036939	IFNGR1/IL18/HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/TLR2/IL1B/HLA-DPB1/HLA-DRB1	9.30125941856046
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/137	109/9376	7.53445389406014	HSP90AA1/HIF1A/IFNGR1/HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/IL2RA/HSP90AB1/IL1B/HLA-DPB1/HLA-DRB1	8.35576858698741
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/137	112/9376	7.33263816475495	HSPA1A/IFNGR1/HLA-DQB1/HSPA1B/HLA-DQA1/HSPA8/HLA-DPA1/HLA-DQA2/TLR2/HLA-DPB1/CYCS/HLA-DRB1	8.20971064191659
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/137	45/9376	12.1667477696675	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/IL1B/HLA-DPB1/HLA-DRB1	9.14328604940741
Human Diseases	Immune disease	hsa05310	Asthma	7/137	32/9376	14.970802919708	FCER1G/HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB1	9.63969690317335
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/137	39/9376	12.2837357289912	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/HLA-DRB1	8.59834701485646
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/137	99/9376	6.91292486912925	FCGR3A/FCGR2A/HLA-DQB1/C1QC/HLA-DQA1/FPR3/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB1	7.2019419753073
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/137	180/9376	4.94274128142741	IFNGR1/HLA-DQB1/B2M/HLA-DQA1/HLA-DPA1/HLA-DQA2/TLR2/IL1B/IRF7/HLA-DPB1/CYCS/OAS1/HLA-DRB1	6.5038196455847
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/137	50/9376	9.58131386861314	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/HLA-DRB1	7.40840168376543
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/137	70/9376	7.82148070907195	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/CYCS/HLA-DRB1	6.97556820434012
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/137	54/9376	8.87158691538253	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/HLA-DRB1	7.06379462569869
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/137	100/9376	6.15941605839416	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/IL2RA/IL1B/HLA-DPB1/CD36/HLA-DRB1	6.3161672184567
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/137	136/9376	5.03220266208673	HSPA1A/HSPA1B/MX1/HSPA8/IL2RA/TLR2/IL1B/IRF7/CYCS/OAS1	5.76778759722888
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/137	42/9376	9.77685088633994	FTL/FTH1/ACSL1/HMOX1/SAT1/CYBB	6.94165307717448
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/137	142/9376	4.81957438059011	FCGR3A/FCGR2A/IFNGR1/LILRB4/NCF1/GRB2/NCF2/SIRPA/IL1B/TYROBP	5.5846716896238
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/137	143/9376	4.78587106324333	FCGR3A/FCGR2A/HLA-DQB1/C1QC/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/HLA-DRB1	5.55515086841394
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/137	93/9376	5.88713601758104	IFNGR1/HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/IL2RA/HLA-DPB1/HLA-DRB1	5.76746760254973
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/137	94/9376	5.82450691101103	HSP90AA1/CXCL8/S100A8/S100A9/CXCL3/HSP90AB1/IL1B/CXCL1	5.72439397356931
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/137	100/9376	5.47503649635037	CCL3/CCL3L1/IL18/CCL8/CXCL8/IL2RA/CXCL3/CXCL1	5.47834842155428
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/137	76/9376	6.30349596619285	PLIN2/FABP5/ACSL1/OLR1/LPL/DBI/CD36	5.65276593529783
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/137	168/9376	4.07368786930831	FTL/HSP90AA1/FTH1/GLUL/IFNGR1/CASP1/NLRP3/HSP90AB1/IL1B/CYBB	4.89514078731773
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/137	137/9376	4.49592413021472	CTSB/CTSL/CTSS/CTSD/BCL2A1/CYCS/CTSZ/CTSH/PARP4	5.01930096120223
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/137	109/9376	5.02296926270676	CCL3/CCL3L1/CXCL8/TLR2/CD80/IL1B/IRF7/MAP3K8	5.14427077407299
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/137	139/9376	4.43123457438429	HSPA1A/HSP90AA1/HSPA1B/HSPA8/HBEGF/CTSD/GRB2/HSP90AB1/CALM1	4.96278859956991
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/137	205/9376	3.67228057682037	HLA-DQB1/B2M/HLA-DQA1/HLA-DPA1/HLA-DQA2/TLR2/IRF7/HLA-DPB1/CYCS/OAS1/HLA-DRB1	4.71068513918469
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/137	174/9376	3.93321587381492	HSPA1A/HSP90AA1/HSPH1/HSPA5/DNAJA1/HSPA1B/HSPA8/HSP90AB1/HERPUD1/DNAJB1	4.75566193611062
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/137	248/9376	3.31151400988933	HSP90AA1/IL18/CXCL8/CASP1/TLR2/NLRP3/HSP90AB1/RIPK2/IL1B/NAIP/CYCS/CYFIP1	4.49229215710858
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/137	193/9376	3.54600809349117	CCL3/CCL3L1/CCL8/CXCL8/NCF1/GRB2/CXCL3/HCK/RAP1A/CXCL1	4.35190674471038
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/137	195/9376	3.50963877971177	FCGR3A/FCGR2A/CASP1/NCF1/FPR3/CLEC7A/NCF2/TLR2/AQP9/CYBB	4.31237944002249
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	11/137	238/9376	3.1630988161688	FCGR2A/C1QC/CXCL8/MX1/CASP1/HBEGF/TLR2/NLRP3/IL1B/CYBB/OAS1	4.11597472784971
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/137	103/9376	4.65112323719084	CCL3/CCL3L1/IFNGR1/C1QC/CXCL8/TLR2/IL1B	4.53699617077755
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/137	50/9376	6.84379562043796	IL18/CXCL8/TLR2/IL1B/CD36	5.04505323740482
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/137	105/9376	4.5625304136253	FCER1G/CASP1/CLEC7A/CLEC4E/NLRP3/IL1B/CALM1	4.47016318866125
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/137	52/9376	6.58057271195957	APOC1/APOE/LPL/CD36/APOC2	4.91374651436042
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/137	78/9376	5.26445816956766	C1QC/CXCL8/CASP1/NLRP3/IL1B/CALM1	4.60521411790865
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/137	142/9376	3.85565950447209	HSP90AA1/CTSL/NCF1/HMOX1/NCF2/HSP90AB1/IL1B/CALM1	4.17531358228623
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/137	83/9376	4.94732213525635	IL18/CASP1/SAMHD1/NLRP3/IL1B/IRF7	4.39842393507964
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/137	157/9376	3.48728439257985	HIF1A/C1QC/CASP1/SGK1/SIGLEC10/CH25H/SIRPA/CD36	3.82707348780616
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/137	196/9376	3.14255921346641	HIF1A/IFNGR1/CXCL8/CXCL3/HCK/IRF7/CYCS/CXCL1/CALM1	3.69124580635528
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/137	160/9376	3.42189781021898	HLA-DQB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CD80/HLA-DPB1/CD226/HLA-DRB1	3.76251301639239
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/137	200/9376	3.07970802919708	FCGR2A/IL18/CXCL8/CASP1/NLRP3/IL1B/NAIP/CYCS/CYFIP1	3.62012946369355
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/137	250/9376	2.73751824817518	LAPTM5/CTSB/CTSL/CTSS/SLC11A1/CTSD/CTSZ/CTSH/SCARB2/ASAH1	3.39072512817123
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/137	298/9376	2.526233282712	CCL3/CCL3L1/IFNGR1/IL18/CCL8/CXCL8/IL2RA/CXCL3/IL1B/CXCL1/TNFSF15	3.26037384911811
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/137	105/9376	3.91074035453598	CXCL8/BCL2A1/CXCL3/IL1B/PLAU/CXCL1	3.65231531352928
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/137	275/9376	2.48865295288653	HSPA1A/HSPA5/C1QC/HSPA1B/HSPA8/NCF1/NCF2/IL1B/CYCS/CYBB	3.05104554839162
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/137	156/9376	3.0709339322478	MX1/IFIT1/GRB2/IRF7/YWHAH/CYCS/OAS1	3.17611720923476
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/137	62/9376	4.41535201318578	HSPA1A/SOD2/HSPA1B/HSPA8	3.28546343632022
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/137	138/9376	2.97556331323389	FCGR2A/IL18/CXCL8/CASP1/NLRP3/IL1B	2.84691797871595
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/137	224/9376	2.44421272158498	HLA-DQB1/B2M/HLA-DQA1/HLA-DPA1/HLA-DQA2/IL2RA/HLA-DPB1/HLA-DRB1	2.66397784007592
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/137	103/9376	3.32223088370775	CXCL8/CXCL3/TLR2/IL1B/CXCL1	2.8856743370705
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/137	227/9376	2.41191035081514	CCL3/CCL3L1/CXCL8/B2M/GRB2/IL1B/CYCS/CALM1	2.62220520493334
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/137	71/9376	3.85565950447209	CXCL8/HBEGF/CXCL3/CXCL1	2.94110714892067
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/137	41/9376	5.00765533202777	CXCL8/HBEGF/TYMP	3.13154437041458
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/137	46/9376	4.46334496985084	FTL/FTH1/HMOX1	2.86726137416008
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/137	204/9376	2.34836124230714	HIF1A/CTSL/HBEGF/PLAUR/GRB2/TLR2/PLAU	2.37095198736663
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/137	253/9376	2.16404604598829	IL18/CXCL8/CASP1/NLRP3/RIPK2/IL1B/NAIP/CYCS	2.28557260196986
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/137	50/9376	4.10627737226277	LAP3/CNDP2/SAT1	2.68170479104421
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/137	88/9376	3.11081619110816	C1QC/PLAUR/PLAU/SERPINA1	2.42250168457826
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/137	133/9376	2.57285549640525	FCER1G/FCGR3A/IFNGR1/GRB2/TYROBP	2.22454710562264
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/137	98/9376	2.7933859675257	FCGR3A/FCGR2A/NCF1/HCK	2.17316678827802
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/137	61/9376	3.36580112480555	FTL/FTH1/HMOX1	2.25727857794736
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/137	144/9376	2.37631792376318	C1QC/CXCL8/CXCL3/IL1B/CXCL1	2.0266817282445
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/137	106/9376	2.58256438507093	HSP90AA1/GRB2/HSP90AB1/PLAU	1.99529857171512
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/137	250/9376	1.91626277372263	HSPA1A/HSPA1B/HSPA8/IL2RA/SNX3/EHD4/DAB2	1.78806479536666
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/137	31/9376	4.41535201318578	DPYD/CNDP2	2.31931696348154
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/137	110/9376	2.48865295288653	HIF1A/IFNGR1/HMOX1/CYBB	1.91239278303813
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/137	69/9376	2.97556331323389	FCER1G/GRB2/ALOX5AP	2.00559888371836
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/137	69/9376	2.97556331323389	CTSB/KCNMA1/CALM1	2.00559888371836
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/137	70/9376	2.93305526590198	HIF1A/GRB2/RAP1A	1.97672022030721
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/137	116/9376	2.35992952428895	NCF1/NCF2/RAP1A/CYBB	1.79462346522804
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/137	163/9376	2.09932380995029	CXCL8/GRB2/TLR2/IRF7/CYCS	1.7240598542952
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/137	73/9376	2.81251874812519	MX1/SAMHD1/ELL2	1.89306647849469
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/137	119/9376	2.30043550266822	CXCL3/IL1B/MAP3K8/CXCL1	1.73844359610601
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/137	120/9376	2.28126520681265	GRB2/RIPK2/RAP1A/CALM1	1.72009099073844
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/137	37/9376	3.69934898402052	IL18/IL1B	2.00328688717681
Organismal Systems	Immune system	hsa04611	Platelet activation	4/137	126/9376	2.17263353029776	FCER1G/FCGR2A/APBB1IP/RAP1A	1.61365301090939
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/137	227/9376	1.80893276311135	HIF1A/SOD2/NCF1/HMOX1/GRB2/NCF2	1.50235296500736
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/137	90/9376	2.28126520681265	HIF1A/IFNGR1/TLR2	1.48723427665792
NA	NA	hsa04517	IgSF CAM signaling	7/137	299/9376	1.60222639943364	NRP2/GRB2/EPB41L3/CD80/RAP1A/DOK1/CD226	1.28871728678673
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/137	300/9376	1.59688564476886	HSPA1A/HSPA1B/HSPA8/GRB2/IL1B/RAP1A/MAP3K8	1.27949312337141
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/137	93/9376	2.20767600659289	HBEGF/GRB2/CALM1	1.42521759520184
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/137	99/9376	2.07387746073877	HIF1A/GRB2/GPCPD1	1.30798265359491
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	5/137	205/9376	1.66921844400926	NCF1/CTSD/NCF2/CD36/CYBB	1.17969550293769
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/137	101/9376	2.03281058032811	CXCL8/IL1B/CYBB	1.27074334592355
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/137	214/9376	1.59901766832663	B2M/SAMHD1/TLR2/CYCS/CALM1	1.07940596440647
NA	NA	hsa04382	Cornified envelope formation	5/137	217/9376	1.57691143328064	S100A11/S100A8/S100A9/ST14/TCHH	1.0470041945436
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/137	59/9376	2.31993071879253	DPYD/TYMP	1.23843304755353
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/137	17/9376	4.02576212966939	CH25H	1.5204703592892
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/137	17/9376	4.02576212966939	GLUL	1.5204703592892
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/137	17/9376	4.02576212966939	NRP2	1.5204703592892
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/137	18/9376	3.80210867802109	ACSL1	1.44898251709726
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/137	169/9376	1.61983328294389	HIF1A/CTSB/CTSL/CTSD	0.990130894165366
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/137	115/9376	1.78533798794034	SGK1/MAFB/HBEGF	1.0318344454522
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/137	20/9376	3.42189781021898	NPL	1.32025902228434
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/137	67/9376	2.04292406580237	RAP1A/CALM1	1.04321065339248
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/137	68/9376	2.01288106483469	BCL2A1/GRB2	1.02074711146608
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/137	21/9376	3.25895029544665	DPYD	1.26190849724891
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/137	70/9376	1.95537017726799	ACSL1/CD36	0.976950623500629
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/137	125/9376	1.64251094890511	FCER1G/CTSD/ASAH1	0.880591800034919
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/137	22/9376	3.11081619110816	CNDP2	1.20697010303036
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/137	362/9376	1.32338589345485	HSP90AA1/SGK1/IL2RA/GRB2/TLR2/HSP90AB1/YWHAH	0.76409968047429
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/137	72/9376	1.90105433901054	CXCL8/IRF7	0.934578569024586
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/137	23/9376	2.97556331323389	GLUL	1.15508206779898
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/137	75/9376	1.82501216545012	GLUL/SDS	0.873493344651458
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/137	76/9376	1.80099884748367	GRB2/CALM1	0.853749871430349
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/137	133/9376	1.54371329784315	SOD2/SGK1/GRB2	0.768993620691703
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/137	78/9376	1.75481938985589	HSPD1/BTG1	0.815134015252385
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/137	82/9376	1.66921844400926	DPYD/TYMP	0.741151398078273
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/137	83/9376	1.64910737841878	SOD2/ACSL1	0.723287669930329
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/137	29/9376	2.35992952428895	MOB1A	0.893125971030511
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/137	29/9376	2.35992952428895	CALM1	0.893125971030511
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/137	30/9376	2.28126520681265	IL1B	0.855894449814136
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/137	86/9376	1.59158037684604	HBEGF/GRB2	0.6711020516979
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/137	87/9376	1.57328634952597	GRB2/CYCS	0.65415427518176
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/137	31/9376	2.20767600659289	GLUL	0.820115595015291
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/137	31/9376	2.20767600659289	HSPA5	0.820115595015291
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/137	149/9376	1.37794542693382	FCER1G/CXCL8/GRB2	0.566272415953897
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/137	32/9376	2.13868613138686	CYCS	0.785680625337013
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/137	91/9376	1.50413090559076	LILRB4/GRB2	0.588445848029642
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/137	33/9376	2.07387746073877	STX6	0.752492127856252
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/137	93/9376	1.47178400439526	KCNMA1/CALM1	0.556767593732257
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/137	157/9376	1.30773164721744	CXCL8/IL1B/CYCS	0.473492951565244
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/137	37/9376	1.84967449201026	GLUL	0.630574919467259
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/137	99/9376	1.38258497382585	HBEGF/GRB2	0.465988464778852
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/137	99/9376	1.38258497382585	IL1B/CALM1	0.465988464778852
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/137	38/9376	1.80099884748367	NAMPT	0.602462740414119
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/137	38/9376	1.80099884748367	SGK1	0.602462740414119
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/137	102/9376	1.3419207098898	KCNMA1/RAP1A	0.422790660207561
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/137	168/9376	1.22210636079249	IFNGR1/IL2RA/GRB2	0.35372554145607
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/137	41/9376	1.66921844400926	SDS	0.522921029202985
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/137	42/9376	1.62947514772332	KYNU	0.49785488585652
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/137	43/9376	1.59158037684604	ACSL1	0.473446371865929
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/137	43/9376	1.59158037684604	CD36	0.473446371865929
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/137	44/9376	1.55540809555408	PARP4	0.449660373712009
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/137	110/9376	1.24432647644326	HSP90AA1/HSP90AB1	0.313873149110564
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/137	45/9376	1.52084347120843	ABCG1	0.426464440896637
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/137	47/9376	1.45612672775276	ME2	0.381724769989969
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/137	388/9376	1.058318910377	APOE/IL1B/LPL/CYCS/CYBB/CALM1	0.142865435774148
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/137	116/9376	1.17996476214448	ME2/SDS	0.237489501691292
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/137	323/9376	1.0594110867551	HMOX1/ZEB2/GRB2/ST14/PLAU	0.132314041732459
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/137	122/9376	1.12193370826852	GRB2/MAP3K8	0.165071610261598
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/137	54/9376	1.26736955934036	SDS	0.239931754123571
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/137	55/9376	1.24432647644326	ASAH1	0.221286062341136
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/137	201/9376	1.02146203290119	CXCL8/BCL2A1/PLAU	0.03745409319424
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/137	57/9376	1.20066589832245	ACSL1	0.185037513500025
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/137	205/9376	1.00153106640555	GRB2/IRF7/YWHAH	0.0026989575220177
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/137	59/9376	1.15996535939626	LAP3	0.150088474129414
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/137	59/9376	1.15996535939626	GRB2	0.150088474129414
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/137	134/9376	1.02146203290119	KCNMA1/CALM1	0.0304700882187535
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/137	138/9376	0.991854437744631	YWHAH/CALM1	-0.0117382963513321
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/137	138/9376	0.991854437744631	GRB2/CALM1	-0.0117382963513321
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/137	212/9376	0.968461644401598	APBB1IP/RAP1A/CALM1	-0.0565584988391928
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/137	65/9376	1.05289163391353	LPL	0.052104944369186
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/137	217/9376	0.946146859968381	HSP90AA1/GRB2/HSP90AB1	-0.0977350425901869
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/137	69/9376	0.991854437744631	CALM1	-0.00826940369725905
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/137	71/9376	0.963914876118022	GRB2	-0.0371648705501369
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/137	71/9376	0.963914876118022	HIF1A	-0.0371648705501369
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/137	73/9376	0.937506249375062	GRB2	-0.0652709521188932
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/137	154/9376	0.888804626030903	KCNE1/CALM1	-0.16942128035784
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/137	75/9376	0.912506082725061	CYCS	-0.092635427255121
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/137	75/9376	0.912506082725061	CYCS	-0.092635427255121
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/137	75/9376	0.912506082725061	HSPA5	-0.092635427255121
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/137	157/9376	0.871821098144963	CXCL8/CALM1	-0.19722315568294
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/137	157/9376	0.871821098144963	MOB1A/YWHAH	-0.19722315568294
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/137	76/9376	0.900499423741836	CALM1	-0.106053341343146
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/137	158/9376	0.866303243093412	SGK1/GRB2	-0.206378524182342
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/137	77/9376	0.888804626030903	GRB2	-0.119301910012545
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/137	238/9376	0.862663313500583	GRB2/RAP1A/CALM1	-0.261326170867872
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/137	80/9376	0.855474452554745	GRB2	-0.15807929751681
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/137	243/9376	0.844913039560241	HSPA1A/HSPA1B/HSPA8	-0.298266948101586
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/137	166/9376	0.824553689209392	KCNMA1/CALM1	-0.277716643454122
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/137	170/9376	0.805152425933877	HMOX1/GRB2	-0.312188870641997
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/137	85/9376	0.805152425933877	TYMP	-0.219738762338437
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/137	86/9376	0.795790188423018	KCNMA1	-0.23166019173388
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/137	89/9376	0.768965800049209	CD36	-0.266665598075338
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/137	89/9376	0.768965800049209	GRB2	-0.266665598075338
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/137	89/9376	0.768965800049209	GLUL	-0.266665598075338
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/137	90/9376	0.760421735604217	SOD2	-0.278091533944012
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/137	90/9376	0.760421735604217	AQP9	-0.278091533944012
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/137	93/9376	0.73589200219763	RAP1A	-0.311682407737322
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/137	93/9376	0.73589200219763	CYCS	-0.311682407737322
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	3/137	268/9376	0.766096524675891	HSPA5/CYCS/CALM1	-0.473070643715222
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/137	97/9376	0.705545940251336	CALM1	-0.35496559771488
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/137	98/9376	0.698346491881424	CALM1	-0.365533910313397
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/137	98/9376	0.698346491881424	CALM1	-0.365533910313397
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/137	191/9376	0.716627813658425	GRB2/CALM1	-0.481801072582109
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/137	101/9376	0.677603526776035	CALM1	-0.396668257376319
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/137	103/9376	0.664446176741549	SLC7A7	-0.416969330343582
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/137	104/9376	0.658057271195957	GPCPD1	-0.42698908120844
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/137	105/9376	0.651790059089329	HIF1A	-0.436924062130548
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/137	107/9376	0.63960706733065	CALM1	-0.456546640984587
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/137	109/9376	0.627871157838345	CD36	-0.475850398527235
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/137	203/9376	0.674265578368272	GRB2/RAP1A	-0.571333138826338
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/137	116/9376	0.589982381072238	GLUL	-0.541077480077084
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/137	122/9376	0.560966854134259	CD36	-0.594354993179396
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/137	122/9376	0.560966854134259	HIF1A	-0.594354993179396
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/137	122/9376	0.560966854134259	GRB2	-0.594354993179396
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/137	480/9376	0.712895377128954	HSPA5/IL1B/CYCS/CYBB/CALM1	-0.786315533634075
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/137	226/9376	0.605645630127253	RAP1A/CALM1	-0.730741493384726
NA	NA	hsa04519	Cadherin signaling	4/137	404/9376	0.677603526776035	LHFPL2/MOB1A/YWHAH/CYFIP1	-0.806621457184572
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/137	130/9376	0.526445816956766	GRB2	-0.662060758182008
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	2/137	232/9376	0.589982381072238	TMSB4X/CYFIP1	-0.770037439477249
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/137	133/9376	0.514571099281049	CALM1	-0.686559864239236
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/137	235/9376	0.582450691101103	ACSL1/GRB2	-0.789365759711257
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/137	138/9376	0.495927218872316	CYCS	-0.726402365118154
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/137	140/9376	0.488842544316997	CALM1	-0.742010743934146
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/137	144/9376	0.475263584752636	GRB2	-0.772694801516906
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/137	144/9376	0.475263584752636	CYCS	-0.772694801516906
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/137	148/9376	0.462418623002565	GRB2	-0.802702690015021
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/137	150/9376	0.45625304136253	GRB2	-0.817465030380975
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/137	154/9376	0.444402313015452	KYNU	-0.84652866511279
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/137	154/9376	0.444402313015452	CALM1	-0.84652866511279
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/137	155/9376	0.441535201318578	RAP1A	-0.853701569845913
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/137	158/9376	0.433151621546706	YWHAH	-0.875005007504264
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/137	368/9376	0.557918121231355	HSPA5/CASP1/CYCS	-1.05352748949549
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/137	170/9376	0.402576212966939	RAP1A	-0.957204924220526
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/137	308/9376	0.444402313015452	SOD2/CYCS	-1.20729518844762
NA	NA	hsa04082	Neuroactive ligand signaling	1/137	199/9376	0.343909327660199	OGFRL1	-1.13913048382612
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/137	333/9376	0.41103877600228	MX1/GRB2	-1.3325576051432
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/137	370/9376	0.369934898402052	FPR3/OGFRL1	-1.50575305950506
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/137	254/9376	0.269440772458187	CALM1	-1.4373439099045
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/137	449/9376	0.152423065043162	CALM1	-2.24121216511626