category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	79/1624	174/9376	2.62125587452579	HSPA5/HSPH1/HSPA1B/DNAJA1/HSPA1A/HYOU1/HSP90AA1/CALR/PDIA4/HERPUD1/HSPA8/UBQLN2/UGGT2/ERN1/DNAJB11/PDIA3/OSTC/SKP1/SAR1B/HSP90AB1/STT3B/EIF2AK3/ERO1B/PDIA6/SSR3/DNAJC3/SEC24A/SEC23A/SEC13/DNAJA2/UGGT1/SEC24D/DERL1/OS9/YOD1/SYVN1/BAG2/UBXN8/EDEM3/GANAB/DERL2/EIF2S1/MAN1C1/DNAJB1/SAR1A/EDEM2/PPP1R15A/DDIT3/UBE2D1/HSP90B1/UFD1/BCAP29/DDOST/CANX/RPN1/MAP2K7/CUL1/MAN1A1/SEC23B/SEC31A/RAD23B/MAPK8/MAPK10/XBP1/EDEM1/UBE2D3/ERO1A/NGLY1/UBE2G1/MAPK9/MBTPS2/DAD1/SEC61B/HSPA4L/VCP/FBXO6/SSR2/SEC61A1/RNF5	9.87999764442216
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	48/1624	108/9376	2.56595511767926	DDX39B/KPNA2/NXF1/NUP98/XPO1/NUP54/THOC1/ACIN1/NUP153/NUP58/EIF4A3/AHCTF1/KPNA4/RNPS1/XPOT/NCBP1/IPO5/SEC13/TNPO1/NXT1/NUP62/XPO5/MAGOHB/NCBP2/TNPO3/IPO7/THOC5/NUP205/RANBP17/SUMO4/NMD3/NUP214/THOC7/MAGOH/NUP160/PNN/SUMO1/TMEM33/UBE2I/XPO4/NUP155/IPO11/THOC3/SEH1L/IPO4/THOC6/RAN/NUP35	7.49152001695391
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	27/1624	56/9376	2.78360309641098	HSPA1B/HSPA1A/SEC22B/HSPD1/NFKBIA/HSPA8/SAR1B/CASP7/HBS1L/CASP3/CYCS/NFKB1/IL6/SAR1A/CXCL8/CLK1/CLK4/RAB1A/MYD88/CASP8/CXCL2/CASP1/BCL2L13/NAIP/VCP/ARF1/CASP9	6.12711516781601
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	48/1624	142/9376	1.95157149795324	CUL3/UBE2H/SKP1/SOCS1/COP1/UBE2N/UBA6/BIRC2/BIRC6/TRIP12/KLHL13/HERC4/UBE2Z/SYVN1/UBE2S/HERC2/VHL/UBA2/SIAH1/BTRC/ANAPC7/CUL2/UBE2D1/UBE2L6/UBE2E1/UBA3/UBE2O/UBE3A/CUL1/ANAPC1/PPIL2/UBE2Q1/UBE4A/UBE2W/FBXO4/UBE2I/UBE2A/NEDD4/CDC26/UBE2B/MDM2/UBE2D3/ANAPC10/UBE2G1/TRAF6/RNF7/SKP2/ERCC8	5.22952725799467
Human Diseases	Infectious disease: viral	hsa05162	Measles	46/1624	136/9376	1.95276731382208	HSPA1B/OAS2/HSPA1A/STAT2/NFKBIA/OAS1/HSPA8/FAS/MX2/MX1/CDKN1B/STAT1/TBK1/IRF7/CCND2/CASP3/TNFAIP3/CYCS/NFKB1/PIK3CA/IL6/EIF2S1/TP53/GSK3B/EIF2AK2/RAB9A/IFIH1/MSN/PIK3R3/BID/ADAR/MYD88/CD46/CASP8/TYK2/IRAK4/CDK4/MAPK8/MAPK10/STAT3/TRAF6/MAPK9/FADD/IL1A/BBC3/CASP9	5.12261936328408
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	51/1624	157/9376	1.87543534874965	GADD45A/MYC/PTEN/PPID/ZFP36L1/MAP2K3/RAD50/ATM/PPP3CC/TRAF3IP2/CCND2/HLA-F/GADD45B/HIPK1/ATR/RBL2/MAPKAPK2/NFKB1/PPP3CB/PIK3CA/CHEK2/IL6/E2F4/HIPK3/TP53/BTRC/PPP1CC/CXCL8/RAD9A/PPP1CB/SIRT1/TRPM7/PIK3R3/SERPINE1/TSC1/NRAS/RAF1/VDAC1/CHEK1/ITPR2/ETS1/NBN/SMAD3/CDK4/MDM2/NFATC1/SLC25A5/CACNA1D/CDKN2B/IL1A/MCU	5.06295148835289
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	62/1624	205/9376	1.74610116544515	OAS2/GADD45A/STAT2/MYC/NFKBIA/CALR/OAS1/FAS/NFKBIE/B2M/CDKN1B/STAT1/TBK1/MAP2K3/SAP30/PDIA3/TAP1/IRF7/CCND2/PSMD6/CASP3/HLA-F/TNFAIP3/GADD45B/CYCS/PSMD12/HDAC1/NFKB1/PIK3CA/CD44/IL6/PSMC6/TP53/EIF2AK2/PSMD11/PIK3R3/BID/TAP2/MAP2K7/USP7/PSMC4/MYD88/SNW1/CASP8/ISG15/TYK2/NEDD4/IRAK4/CDK4/MAPK8/MDM2/PLCG2/MAPK10/PSMC2/STAT3/TRAF6/MAPK9/HLA-DOB/FADD/SKP2/RIPK1/CASP9	4.94354020798796
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	56/1624	180/9376	1.79616858237548	OAS2/STAT2/NFKBIA/CALR/SRSF1/OAS1/IFNGR1/SRSF7/FAS/B2M/STAT1/SRSF2/TBK1/TNFRSF1A/NXF1/PDIA3/SRSF6/TAP1/IRF7/SP100/CASP3/HLA-F/CYCS/BIRC2/CGAS/SRSF9/NFKB1/PIK3CA/IL6/EIF2S1/TP53/EIF2AK2/PPP1CC/TNFSF14/PPP1CB/IFIH1/IFNGR2/PIK3R3/BID/TAP2/EIF2B3/SRSF5/TSC1/RNASEL/PILRA/SRSF4/MYD88/CASP8/TYK2/IRAK4/TRAF6/HLA-DOB/ITGB3/ZC3HAV1/FADD/CASP9	4.93643673802963
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	102/1624	388/9376	1.51774922553451	SLC39A14/CSF1/PPID/PSMA2/PSMA3/ADAM17/FAS/MME/ERN1/TNFRSF1A/CASP7/PPP3CC/EIF2AK3/ATP2A2/PSMD6/ADAM10/CASP3/SLC39A7/CYCS/FZD2/MT-ND4L/PSMD12/SDHD/NFKB1/WNT2/PPP3CB/PIK3CA/IL6/NDUFC2/PSMC6/NDUFB3/EIF2S1/GSK3B/PSEN1/EIF2AK2/PSMD11/MT-ATP8/PPIF/DDIT3/NRBF2/SLC11A2/NDUFB5/LRP6/SLC39A1/LRP1/SLC39A10/PIK3R3/ATG2B/BID/CTNNB1/ATG101/FZD8/IDE/NRAS/MAP2K7/RAF1/SDHB/NDUFB8/VDAC1/NDUFA9/NAE1/ITPR2/PSMC4/SLC39A6/PLCB3/CASP8/RTN3/MT-ND4/NDUFV2/PSMB2/NDUFA5/MAPK8/PSMA1/MAPK10/UQCRFS1/SDHC/XBP1/ATP5MC1/NCSTN/PSMC2/ATG13/NDUFAB1/SLC25A5/WNT6/AMBRA1/MAPK9/PSMA6/NDUFA7/CSNK1A1/PSMB5/CACNA1D/MT-CO1/FADD/IL1A/PSMA4/BRAF/MT-ND5/MCU/PSMD9/KIF5A/NDUFB4/CASP9	4.767333756001
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	41/1624	119/9376	1.98915428240262	VCAM1/CSF1/MAP3K8/IRF1/NFKBIA/CYLD/ADAM17/FAS/TNFRSF1A/MAP2K3/CASP7/CASP3/TNFAIP3/BIRC2/NFKB1/PIK3CA/IL6/CEBPB/DNM1L/RHBDF1/MLKL/TRAF1/ATF2/PIK3R3/CREB5/CASP10/MAP2K7/TAB3/JAG1/CASP8/JUNB/CREB3L4/CXCL2/VEGFC/MAPK8/MAPK10/IL15/MAPK9/MMP14/FADD/RIPK1	4.97020329588163
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	34/1624	93/9376	2.11070501615552	GADD45A/CKS2/MYC/NFKBIA/PTEN/LAMA2/CDKN1B/COL4A1/LAMB1/MAX/CASP3/GADD45B/CYCS/BIRC2/NFKB1/PIK3CA/TP53/COL4A6/CKS1B/TRAF1/PIK3R3/COL4A5/FHIT/ITGAV/ITGA6/COL4A2/CDK4/TRAF6/TRAF4/CDKN2B/SKP2/LAMC1/LAMA1/CASP9	4.92683253757155
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	36/1624	103/9376	2.01788703429145	DDX39B/PELO/CPSF6/ETF1/PABPN1/NXF1/HBS1L/ACIN1/PPP2R2A/EIF4A3/RNPS1/NCBP1/RNMT/TARDBP/NXT1/RNGTT/MAGOHB/NCBP2/PPP1CC/PPP1CB/PAPOLA/SMG1/MSI2/PPP2R1B/FIP1L1/PPP2R3A/GSPT1/MAGOH/PNN/WDR33/CSTF2/PPP2R5A/PPP2CA/FUS/PABPC5/PPP2R5B	4.75422611732593
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	29/1624	78/9376	2.14652014652015	HSPD1/PATL1/HSPA9/PFKM/DCP1A/MTREX/DDX6/MPHOSPH6/LSM1/C1D/PNPT1/CNOT2/TENT4B/XRN2/LSM6/EXOSC3/PAN3/BTG3/LSM5/DCP2/LSM8/CNOT9/CNOT6/TOB1/EXOSC5/LSM2/PABPC5/BTG2/DCP1B	4.65378150769162
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	16/1624	32/9376	2.88669950738916	TNFRSF1A/CASP7/BOK/CASP3/CYCS/BIRC2/BIRC6/PMAIP1/BID/CASP8/MAPK8/MAPK10/MAPK9/FADD/BBC3/CASP9	4.89308859195564
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/1624	173/9376	1.73535692929753	OAS2/STAT2/NFKBIA/OAS1/IFNGR1/FAS/MX2/MX1/CALCOCO2/STAT1/PABPN1/TBK1/KPNA2/TNFRSF1A/NXF1/NUP98/XPO1/RSAD2/IRF7/CASP3/TRIM25/CYCS/DNAJC3/NFKB1/PIK3CA/NXT1/IL6/EIF2S1/DNAJB1/PRKCA/EIF2AK2/CXCL8/IFIH1/IFNGR2/PIK3R3/BID/ADAR/TNFRSF10B/RAF1/RNASEL/VDAC1/MYD88/CASP8/TYK2/CASP1/IRAK4/CDK4/SLC25A5/HLA-DOB/FADD/IL1A/CASP9	4.4681556994019
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	55/1624	187/9376	1.69805853375833	OAS2/STAT2/HSP90AA1/TXN/GBP3/NFKBIA/OAS1/ANTXR1/RIPK2/STAT1/TBK1/HSP90AB1/IRF7/GBP1/TANK/TNFAIP3/TP53BP1/IFI16/BIRC2/ATG16L1/CASP4/NFKB1/IL6/NAMPT/DNM1L/PANX1/CXCL8/TRPM7/TXNIP/PKN2/GBP2/TAB3/ATG5/RNASEL/VDAC1/NEK7/ITPR2/MYD88/PLCB3/CASP8/TYK2/CXCL2/CASP1/IRAK4/MAPK8/MAPK10/NLRP1/NAIP/TRAF6/MAPK9/FADD/GBP4/RIPK1/MAP1LC3B/MCU	4.41316623599161
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	28/1624	75/9376	2.15540229885057	GADD45A/PTEN/FAS/ATM/CCND2/COP1/CASP3/GADD45B/CYCS/ATR/SESN2/GORAB/CHEK2/PMAIP1/SIAH1/TP53/RPRM/BID/SERPINE1/TNFRSF10B/CHEK1/CASP8/CDK4/MDM2/SESN1/RRM2B/BBC3/CASP9	4.59801946485371
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	45/1624	144/9376	1.80418719211823	PSMA2/PSMA3/ERN1/ATXN2L/OMA1/GTF2B/ATP2A2/PSMD6/CYCS/PSMD12/PIK3CA/PSMC6/PRKCA/NFYA/TBPL1/PSMD11/PPIF/NOP56/NRBF2/PIK3R3/ATG2B/ATG101/KCND3/VDAC1/ITPR2/PSMC4/PLCB3/PSMB2/MAPK8/PSMA1/MAPK10/XBP1/PSMC2/ATG13/ATXN1/SLC25A5/AMBRA1/MAPK9/SP1/PSMA6/PSMB5/PSMA4/TBP/MCU/PSMD9	4.45104790855143
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	94/1624	368/9376	1.47472692225316	HSPA5/GPX8/PSMA2/PSMA3/UBQLN2/SRSF7/ERN1/TBK1/TNFRSF1A/NXF1/MAP2K3/ATXN2L/NUP98/NUP54/PPP3CC/EIF2AK3/NUP153/NUP58/PSMD6/TANK/CASP3/SETX/CYCS/HNRNPA2B1/HNRNPA3/MT-ND4L/NCBP1/PSMD12/TARDBP/SDHD/SEC13/CAT/DERL1/PPP3CB/NXT1/NDUFC2/NUP62/PSMC6/NDUFB3/EIF2S1/TP53/PSMD11/MT-ATP8/DDIT3/NRBF2/NDUFB5/NUP205/ATG2B/BID/RAB5A/ATG101/RAB1A/NUP214/ACTR10/SDHB/NUP160/NDUFB8/VDAC1/NDUFA9/PSMC4/CASP1/MT-ND4/NDUFV2/PSMB2/NDUFA5/PSMA1/UQCRFS1/SDHC/XBP1/ATP5MC1/PSMC2/NUP155/ATG13/NDUFAB1/DNAH14/DNAH11/AMBRA1/PSMA6/NDUFA7/PSMB5/C9orf72/MT-CO1/SEH1L/PSMA4/FUS/MT-ND5/MAP1LC3B/MCU/PSMD9/VCP/KIF5A/NDUFB4/NUP35/CASP9	4.25231424131664
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	34/1624	101/9376	1.94352046042043	VCAM1/COL3A1/CDKN1B/STAT1/COL4A1/CASP3/NFKB1/PIK3CA/IL6/PIM1/PRKCA/COL4A6/CXCL8/F3/PIK3R3/COL4A5/SERPINE1/COL1A1/NRAS/COL1A2/COL4A2/PLCB3/EGR1/SMAD3/VEGFC/CDK4/MAPK8/PLCG2/NFATC1/MAPK10/STAT3/MAPK9/IL1A/CDC42	4.36341799885882
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	19/1624	44/9376	2.49305866547246	GTF2H2/TAF13/GTF2I/GTF2B/TAF7/TAF12/TBPL1/TAF15/CCNH/ERCC3/GTF2H3/GTF2F2/GTF2H2C/GTF2A2/TAF2/GTF2E1/TBP/GTF2H5/TAF7L	4.54346947096576
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	62/1624	224/9376	1.59799437016186	ZFP36/MYC/NFKBIA/CALR/PTEN/B2M/TNFRSF1A/FOSL1/XPO1/ATM/NRP1/PPP3CC/IL15RA/CCND2/HLA-F/NFYB/ATR/IL1R1/NFKB1/PPP3CB/PIK3CA/CHEK2/IL6/TP53/BUB3/ADCY3/TBPL1/ANAPC7/ATF2/PIK3R3/CREB5/KAT2A/CANX/NRAS/ANAPC1/DLG1/ELK1/VDAC1/CHEK1/EGR1/ETS1/CREB3L4/SMAD3/CDC26/CDK4/MAPK8/NFATC1/MAPK10/IL15/TLN2/ANAPC10/RANBP1/ETS2/POLB/SLC25A5/MAPK9/HLA-DOB/CRTC2/CDKN2B/TBP/CD4/RAN	4.14605317104168
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	60/1624	216/9376	1.60372194854953	HSPA5/HSPA1B/VCAM1/HSPA1A/SOD2/HSPD1/HSP90AA1/NFKBIA/HSPA8/FAS/ABCA1/ERN1/HSPA4/TBK1/TNFRSF1A/MAP2K3/HSP90AB1/CASP7/PPP3CC/IRF7/EIF2AK3/CAMK2D/TANK/CASP3/CYCS/NFKB1/PPP3CB/PIK3CA/IL6/EIF2S1/TP53/GSK3B/PRKCA/DDIT3/CXCL8/HSP90B1/PIK3R3/BID/TNFRSF10B/NRAS/MAP2K7/ARHGEF1/MYD88/PLCB3/CASP8/CXCL2/CASP1/CYP2A7/IRAK4/MAPK8/NFATC1/MAPK10/XBP1/ERO1A/STAT3/LDLR/TRAF6/MAPK9/CDC42/CASP9	4.10854333869646
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	41/1624	137/9376	1.7278055445687	GADD45A/NFKBIA/FAS/ERN1/TNFRSF1A/ATM/CASP7/EIF2AK3/MCL1/CASP3/GADD45B/CYCS/BIRC2/CTSC/PARP4/NFKB1/PIK3CA/PMAIP1/EIF2S1/TP53/AIFM1/DDIT3/TRAF1/PIK3R3/BID/CASP10/TNFRSF10B/NRAS/RAF1/CASP2/ITPR2/CASP8/MAPK8/MAPK10/PARP1/SPTAN1/MAPK9/FADD/RIPK1/BBC3/CASP9	3.92766942952991
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/1624	112/9376	1.80418719211823	HSPA1B/HSPA1A/NFKBIA/IFNGR1/HSPA8/LAMA2/STAT1/TNFRSF1A/MAP2K3/GNAO1/SOCS1/GNAI1/LAMB1/CASP3/CYCS/BIRC2/NFKB1/GNAI3/PPIF/IFNGR2/ITGA6/MYD88/CASP8/TYK2/IRAK4/MAPK8/MAPK10/STAT3/LDLR/TRAF6/MAPK9/HLA-DOB/LAMC1/LAMA1/CASP9	3.91866969956759
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/1624	83/9376	1.94765267968425	SKP1/MAX/AUTS2/RNF2/HDAC1/MBD5/PHF1/SCML1/AEBP2/EED/UBE2D1/PCGF5/JARID2/WDR5/RYBP/USP7/ASXL1/PHC1/L3MBTL3/UBE2D3/TEX10/MTF2/PCGF3/FOXK1/FOXK2/EZH2/PHF19/SUZ12	3.96900861200442
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/1624	75/9376	2.00144499178982	MGST1/FAS/GSTM3/ATM/TOP2B/CASP3/CYCS/BIRC2/PIK3CA/PMAIP1/MSH6/TP53/GSTA4/MSH3/PIK3R3/BID/MLH1/CASP8/ERBB2/MDM2/GSTT2B/GSTM2/GSTM4/FADD/BBC3/CASP9	3.98533356720053
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	113/1624	480/9376	1.35915435139573	HSPA5/CSF1/SNCAIP/PPID/GPX8/PSMA2/PSMA3/FAS/ERN1/TBK1/TNFRSF1A/IFT57/MAP2K3/ATXN2L/PRNP/CASP7/PPP3CC/EIF2AK3/CAMK2D/ATP2A2/PSMD6/TANK/CASP3/UCHL1/CYCS/FZD2/MT-ND4L/PSMD12/TARDBP/SDHD/CAT/DERL1/NFKB1/WNT2/PPP3CB/IL6/NDUFC2/PSMC6/NDUFB3/EIF2S1/GSK3B/PRKCA/PSEN1/PSMD11/MT-ATP8/PPIF/DDIT3/NRBF2/NDUFB5/LRP6/UBE2L6/ATG2B/BID/RAB5A/CTNNB1/ATG101/FZD8/RAB1A/NRAS/ACTR10/MAP2K7/RAF1/SDHB/NDUFB8/VDAC1/NDUFA9/ITPR2/PSMC4/PLCB3/CASP8/MT-ND4/NDUFV2/PSMB2/NDUFA5/MAPK8/PSMA1/MAPK10/UQCRFS1/SDHC/XBP1/ATP5MC1/PSMC2/ATG13/ATXN1/NDUFAB1/UBE2G1/DNAH14/DNAH11/SLC25A5/WNT6/AMBRA1/MAPK9/PSMA6/NDUFA7/CSNK1A1/GRIA4/PSMB5/CACNA1D/C9orf72/MT-CO1/FADD/IL1A/PSMA4/FUS/BRAF/MT-ND5/MAP1LC3B/MCU/PSMD9/VCP/KIF5A/NDUFB4/CASP9	3.69722714336906
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	69/1624	268/9376	1.48643482096905	HSPA5/SLC39A14/TXN/SNCAIP/PSMA2/PSMA3/ERN1/EIF2AK3/CAMK2D/GNAI1/DUSP1/PSMD6/CASP3/SLC39A7/UCHL1/CYCS/MT-ND4L/PSMD12/SDHD/NDUFC2/PSMC6/NDUFB3/EIF2S1/TP53/GNAI3/PSMD11/MT-ATP8/PPIF/DDIT3/SLC11A2/NDUFB5/SLC39A1/UBE2L6/SLC39A10/SDHB/NDUFB8/VDAC1/NDUFA9/ITPR2/PSMC4/SLC39A6/MT-ND4/NDUFV2/PSMB2/NDUFA5/MAPK8/PSMA1/MAPK10/UQCRFS1/SDHC/XBP1/ATP5MC1/PSMC2/NDUFAB1/UBE2G1/SLC25A5/MAPK9/PSMA6/NDUFA7/PSMB5/MT-CO1/PSMA4/MT-ND5/GNAL/MCU/PSMD9/KIF5A/NDUFB4/CASP9	3.69787571587442
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/1624	158/9376	1.64432250420902	GADD45A/CDC25B/MYC/WEE1/CDKN1B/SKP1/ATM/CCND2/GADD45B/ATR/YWHAG/RBL2/HDAC1/CHEK2/CDC7/E2F4/TP53/BUB3/GSK3B/DBF4/HDAC8/ANAPC7/ABL1/CCNH/PPP2R1B/TFDP2/CUL1/ANAPC1/CHEK1/PDS5B/SMAD3/PPP2R5A/CDC26/STAG1/CDK4/MDM2/ESCO1/ANAPC10/PPP2CA/CDC6/NDC80/CDKN2B/SKP2/PRKDC/PPP2R5B	3.73839563044676
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	60/1624	227/9376	1.52600855016167	MYC/NFKBIA/CALR/CXCL12/FAS/B2M/TBK1/TNFRSF1A/PDIA3/GNAO1/PDGFRA/TAP1/PPP3CC/GNAI1/SOS2/CASP3/HLA-F/CYCS/IL1R1/CGAS/NFKB1/PPP3CB/PIK3CA/ARHGEF11/IL6/TP53/GSK3B/PRKCA/ADCY3/GNAI3/ARHGEF12/CXCL8/ATF2/PIK3R3/BID/TAP2/CREB5/CTNNB1/GNG4/TSC1/ITGAV/NRAS/RAF1/SOS1/ELK1/ARHGEF1/ITPR2/PLCB3/CASP8/CREB3L4/CDK4/MDM2/NFATC1/STAT3/GNA12/SP1/ITGB3/FADD/RIPK1/CASP9	3.67189866272171
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	18/1624	46/9376	2.25915613621761	PSMA2/PSMA3/PSME4/PSMD6/PSMD12/PSMB9/PSMC6/PSME2/PSMD11/PSMB8/PSMC4/PSMB2/PSMA1/PSMC2/PSMA6/PSMB5/PSMA4/PSMD9	3.91822569986446
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	82/1624	333/9376	1.42167783547094	STAT2/IRF1/PTEN/FAS/LAMA2/MX2/MX1/CDKN1B/STAT1/TBK1/TNFRSF1A/ATM/COL4A1/MAML2/PDGFRB/CCND2/LAMB1/PPP2R2A/TCF7/SOS2/CASP3/HLA-F/FZD2/ATR/RBL2/HDAC1/NFKB1/WNT2/PIK3CA/TP53/GSK3B/PSEN1/TBPL1/EIF2AK2/COL4A6/PIK3R3/COL4A5/CREB5/PPP2R1B/CTNNB1/TUBG1/ATP6V1E2/FZD8/PPP2R3A/TSC1/COL1A1/UBE3A/ITGAV/NRAS/RAF1/ITGB5/SOS1/COL6A1/VTN/DLG1/ITGA6/COL1A2/COL4A2/JAG1/CASP8/ISG15/TYK2/CREB3L4/PPP2R5A/MAML1/CDK4/MDM2/ATP6V1C1/PPP2CA/WNT6/CSNK1A1/ITGB3/FADD/TADA3/HES4/CDC42/TBP/LAMC1/LAMA1/HEY1/PPP2R5B/CHD4	3.5860669543839
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	64/1624	248/9376	1.4899094231686	HSP90AA1/TXN/MYC/NFKBIA/RIPK2/TNFRSF1A/MAP2K3/SKP1/HSP90AB1/CASP7/ARL8B/TCF7/CASP3/CYCS/KPNA4/BIRC2/M6PR/CASP4/NFKB1/PIK3CA/IL6/ELMO2/VPS39/RAB9A/DYNC2H1/CXCL8/HSP90B1/ARF6/MLKL/ACBD3/RAB5A/CTNNB1/DYNLL1/TNFRSF10B/PLEKHM2/ACTR10/MAP2K7/RAF1/TAB3/EXOC2/EXOC5/DYNC1H1/MYD88/DYNLT3/CASP8/CASP1/IRAK4/MAPK8/MAPK10/RHOB/WASF3/ARPC5L/NAIP/TRAF6/MAPK9/RAB7A/ARL8A/FADD/RIPK1/CDC42/DYNLT1/ARF1/KIF5A/ACTR3	3.57870241451999
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	44/1624	156/9376	1.62839459391184	IFIT1/OAS2/STAT2/MYC/NFKBIA/OAS1/FAS/MX2/MX1/STAT1/TBK1/TNFRSF1A/RSAD2/IRF7/PPP2R2A/SOS2/CASP3/CYCS/YWHAG/NFKB1/PIK3CA/EIF2S1/TP53/GSK3B/EIF2AK2/PIK3R3/BID/PPP2R1B/CTNNB1/NRAS/RAF1/SOS1/RNASEL/CASP8/TYK2/CDK4/PPP2CA/STAT3/LDLR/TRAF6/FADD/BRAF/RIPK1/CASP9	3.62243872068842
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	41/1624	144/9376	1.64381499726327	NFKBIA/FAS/TBK1/TNFRSF1A/MAP2K3/TRA2A/ALDH2/TCF7/CASP3/LPIN1/SREBF1/ALDH9A1/CPT1C/NFKB1/ALDH7A1/IL6/GSK3B/ADH5/CXCL8/C2/SIRT1/CTNNB1/ALDH3A2/ACADVL/TRA2B/MAP2K7/TAB3/ACADM/MYD88/CASP8/CXCL2/IRAK4/MAPK8/MAPK10/ADH1B/TRAF6/MAPK9/FADD/ACACA/RIPK1/C4B	3.56341337582686
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	45/1624	163/9376	1.59388316358911	STAT2/MYC/NFKBIA/FAS/STAT1/TBK1/MAP2K3/IRF7/SOS2/CASP3/CYCS/NFKB1/PIK3CA/IL6/TP53/PRKCA/CXCL8/IFIH1/DDX3X/ATF2/PIK3R3/BID/CREB5/CASP10/NRAS/MAP2K7/RAF1/SOS1/ELK1/MYD88/CASP8/TYK2/CREB3L4/SMAD3/IRAK4/MAPK8/NFATC1/MAPK10/EGR3/STAT3/TRAF6/MAPK9/FADD/BRAF/CASP9	3.50078990992994
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	56/1624	214/9376	1.51079600386723	NFKBIA/CALR/TRIM5/FAS/B2M/WEE1/TBK1/TNFRSF1A/MAP2K3/PDIA3/AP1G1/SKP1/ATM/GNAO1/TAP1/PPP3CC/GNAI1/CASP3/HLA-F/CYCS/ATR/CGAS/NFKB1/PPP3CB/PIK3CA/PRKCA/GNAI3/BTRC/PIK3R3/BID/TAP2/AP1S1/GNG4/NRAS/MAP2K7/CUL1/RAF1/APOBEC3G/CHEK1/ITPR2/MYD88/CASP8/IRAK4/MAPK8/PLCG2/NFATC1/MAPK10/PAK4/TRAF6/AP1S3/MAPK9/RNF7/FADD/RIPK1/CD4/CASP9	3.45964073943491
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	24/1624	72/9376	1.92446633825944	NFKBIA/CYLD/TBK1/IRF7/TANK/TRIM25/NFKB1/AZI2/CXCL8/IFIH1/DDX3X/CASP10/ADAR/ATG5/DHX58/SIKE1/CASP8/ISG15/MAPK8/MAPK10/TRAF6/MAPK9/FADD/RIPK1	3.60407871974231
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	13/1624	30/9376	2.50180623973727	IDH3A/ACO1/SDHD/FH/SUCLG2/MDH1/SUCLA2/SUCLG1/DLD/DLST/SDHB/SDHC/ACLY	3.77079925025156
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	75/1624	308/9376	1.40586014970251	SOD2/GPX8/PSMA2/PSMA3/ERN1/IFT57/PSMD6/CASP3/CYCS/POLR2K/MT-ND4L/PSMD12/SDHD/HDAC1/POLR2B/NDUFC2/PSMC6/TFAM/NDUFB3/TP53/TBPL1/PSMD11/MT-ATP8/PPIF/NRBF2/NDUFB5/ATG2B/CREB5/ATG101/POLR2C/POLR2A/ACTR10/MAP2K7/SDHB/NDUFB8/VDAC1/NDUFA9/PSMC4/PLCB3/CASP8/CREB3L4/MT-ND4/NDUFV2/PSMB2/NDUFA5/MAPK8/PSMA1/MAPK10/UQCRFS1/SDHC/ATP5MC1/PSMC2/ATG13/CLTCL1/TGM2/NDUFAB1/DNAH14/DNAH11/SLC25A5/AMBRA1/MAPK9/SP1/PSMA6/NDUFA7/GRIA4/PSMB5/MT-CO1/PSMA4/MT-ND5/TBP/PSMD9/BBC3/KIF5A/NDUFB4/CASP9	3.31487977856439
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	15/1624	38/9376	2.27897329530723	NAMPT/SIRT1/NT5E/NUDT12/AOX1/BST1/NT5C2/NADK2/NNMT/SIRT6/NMNAT1/NNT/CD38/PNP/ENPP1	3.61574761775079
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	68/1624	275/9376	1.42760412001791	HSPA5/HSPA1B/STIP1/HSPA1A/HSPA8/PSMA2/PSMA3/PRNP/PPP3CC/EIF2AK3/PSMD6/CASP3/CYCS/MT-ND4L/PSMD12/SDHD/PPP3CB/PIK3CA/IL6/NDUFC2/PSMC6/NDUFB3/EIF2S1/GSK3B/PSMD11/MT-ATP8/PPIF/DDIT3/NDUFB5/ATF2/PIK3R3/CREB5/SDHB/NDUFB8/VDAC1/NDUFA9/ITPR2/PSMC4/EGR1/CREB3L4/MT-ND4/NDUFV2/PSMB2/NDUFA5/MAPK8/PSMA1/MAPK10/UQCRFS1/SDHC/ATP5MC1/PSMC2/NDUFAB1/SLC25A5/MAPK9/PSMA6/NDUFA7/PSMB5/CACNA1D/MT-CO1/IL1A/PSMA4/MT-ND5/LAMC1/MCU/PSMD9/KIF5A/NDUFB4/CASP9	3.29408983888652
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/1624	83/9376	1.80853463113538	NFKBIA/TBK1/CASP7/IRF7/G3BP1/CASP3/POLR2K/IFI16/CGAS/POLR3D/NFKB1/IL6/GSDME/POLR3A/POLR1C/MLKL/ADAR/CASP8/POLR3B/CASP1/ZCCHC3/POLR3K/FADD/POLR1D/RIPK1/POLR3F	3.38634711099995
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	47/1624	178/9376	1.52443681850888	CACYBP/MYC/BAMBI/TLE4/PRICKLE2/FOSL1/SKP1/TLE1/PPP3CC/SERPINF1/CAMK2D/CCND2/TCF7/LZTS2/RYK/FZD2/WNT2/PPP3CB/SIAH1/TP53/GSK3B/PRKCA/ROR2/PSEN1/BTRC/INVS/PRICKLE1/SIRT1/LRP6/CTNNB1/FZD8/CHD8/CUL1/APCDD1/PLCB3/SFRP4/SMAD3/PPARD/MAPK8/NFATC1/MAPK10/CTNNBIP1/WNT6/MAPK9/CSNK1A1/TBL1XR1/CCAR2	3.2331677728842
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/1624	116/9376	1.64243247834211	RPE/PFKM/IDH3A/HIBCH/ACO1/SDHD/CAT/FH/GLUD1/ADH5/SUCLG2/GCSH/MDH1/SUCLA2/SUCLG1/DLD/TKT/DLST/PRPS1/MCEE/SDHB/GOT1/PSPH/SHMT2/PGP/SDHC/ACSS2/RPIA/RGN/ESD/G6PD/PRPS2/ACAT2	3.18656483046663
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	52/1624	205/9376	1.46447194521206	NFKBIA/GTF2H2/CDKN1B/GTF2B/IRF7/CCND2/SP100/CASP3/HLA-F/YWHAG/RBL2/MAPKAPK2/HDAC1/NFKB1/PIK3CA/PMAIP1/TP53/TBPL1/HDAC8/EIF2AK2/HDAC3/DDX3X/TRAF1/ATF2/PIK3R3/CREB5/KAT2A/UBE3A/NRAS/DLG1/USP7/GTF2H3/CHEK1/SNW1/CASP8/CREB3L4/CDK4/MDM2/ACTN1/EGR3/STAT3/GTF2H2C/RANBP1/POLB/GTF2A2/CDKN2B/SKP2/GTF2E1/REL/CDC42/TBP/CHD4	3.07751259880187
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	26/1624	87/9376	1.72538361361191	GADD45A/MYC/TCF7/SOS2/CASP3/GADD45B/CYCS/PIK3CA/PMAIP1/MSH6/TP53/GSK3B/MSH3/PIK3R3/CTNNB1/MLH1/NRAS/RAF1/SOS1/SMAD3/MAPK8/MAPK10/MAPK9/BRAF/BBC3/CASP9	3.11110489495998
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	56/1624	227/9376	1.42427464681756	PRKD3/SOD2/NFKBIA/PTEN/MGST1/HIF1A/GSTM3/SOS2/MT-ND4L/SDHD/CAT/NFKB1/PIK3CA/NDUFC2/NDUFB3/MT-ATP8/PPIF/ABL2/ABL1/NDUFB5/GSTA4/PIK3R3/PLD1/NRAS/MAP2K7/RAF1/SDHB/SOS1/NDUFB8/VDAC1/NDUFA9/CBR1/NQO1/MT-ND4/PRKD1/NDUFV2/NDUFA5/MAPK8/MAPK10/UQCRFS1/SDHC/ATP5MC1/GSTT2B/NDUFAB1/GSTM2/SLC25A5/MAPK9/GSTM4/NDUFA7/HGF/MT-CO1/BRAF/MT-ND5/EPHX2/EPHX1/NDUFB4	2.96172658751897
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/1624	34/9376	2.20747609388583	POLR2K/CRCP/POLR3D/POLR2B/POLR3A/POLR1C/POLR2C/POLR2A/POLR2M/POLR3B/POLR3K/POLR1D/POLR3F	3.2282699001297
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	51/1624	204/9376	1.44334975369458	MYC/PLAU/FAS/HIF1A/DDX5/TWIST1/FGF2/CAMK2D/SOS2/CASP3/SDC4/FZD2/WNT2/PIK3CA/CD44/TFAP4/TP53/HOXD10/PRKCA/ARHGEF12/PPP1CC/PPP1CB/PDCD4/SLC9A1/MSN/PIK3R3/CTNNB1/FZD8/ESR1/COL1A1/ITGAV/NRAS/RAF1/ITGB5/SOS1/VTN/ELK1/ARHGEF1/COL1A2/CTTN/ITPR2/ERBB2/MDM2/PLCG2/STAT3/WNT6/FGFR1/ITGB3/HGF/BRAF/CDC42	2.9302272367207
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	22/1624	71/9376	1.78894053979047	SOCS2/IRF1/STAT1/SOCS1/CCND2/SOS2/NFKB1/PIK3CA/GSK3B/PIK3R3/ESR1/NRAS/RAF1/SOS1/SOCS4/SHC3/MAPK8/MAPK10/STAT3/GALT/MAPK9/CISH	3.05412654120997
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	19/1624	59/9376	1.8592301911998	GADD45A/MYC/PTEN/TCF7/SOS2/GADD45B/PIK3CA/TP53/GSK3B/PIK3R3/CTNNB1/MLH1/NRAS/RAF1/SOS1/ELK1/ERBB2/BRAF/CASP9	3.03018577678199
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	49/1624	196/9376	1.44334975369458	ZFP36/STAT2/MYC/NFKBIA/IFNGR1/FAS/HIF1A/STAT1/TBK1/TNFRSF1A/PPP3CC/IRF7/FGF2/TCF7/CASP3/HLA-F/CYCS/MAPKAPK2/NFKB1/PPP3CB/PIK3CA/IL6/TP53/GSK3B/EIF2AK2/CXCL8/ATG3/PIK3R3/BID/CTNNB1/GNG4/NRAS/MAP2K7/RAF1/ITPR2/CASP8/TYK2/CXCL2/CDK4/MAPK8/PLCG2/NFATC1/MAPK10/STAT3/MAPK9/CLEC2B/FADD/MAP1LC3B/CASP9	2.87094541405914
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/1624	31/9376	2.2348641347529	HSPA5/SRPRB/SRP54/SPCS3/SRPRA/SRP9/TMEM208/IMMP2L/SPCS1/SEC61B/SPCS2/SEC61A1	3.15197046898488
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	60/1624	250/9376	1.3856157635468	HSPA1B/HSPA1A/HSPA8/VPS26A/ARF4/PDGFRA/ARFGAP3/SPART/EPS15L1/HLA-F/IST1/EHD1/IGF2R/CHMP5/WASHC2A/SNX1/RUFY1/ZFYVE16/GBF1/STAMBP/EPS15/SPG21/VPS37A/CAPZA1/ARF6/ARFGAP2/RAB5A/VPS45/STAM/PLD1/ARFGEF2/RAB11FIP2/PSD3/STAM2/PIP5K1A/DNM1/SMAD3/NEDD4/MDM2/SNX5/SNX2/CLTCL1/LDLR/ARPC5L/RAB11FIP3/WASHC5/SNX3/TRAF6/RAB7A/AMPH/GIT1/RAB10/RAB4A/MVB12A/CDC42/AGAP6/ARF1/CHMP7/KIF5A/ACTR3	2.82850089060224
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	29/1624	103/9376	1.625520110957	NFKBIA/CALR/IFNGR1/FAS/TNFRSF1A/BDKRB2/GNAO1/GNAI1/PPP2R2A/NFKB1/PIK3CA/IL6/GNAI3/CXCL8/IFNGR2/PIK3R3/SERPINE1/PPP2R1B/MYD88/PLCB3/CASP8/IRAK4/MAPK8/MAPK10/PPP2CA/TRAF6/MAPK9/FADD/GNAL	2.92160519609575
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/1624	43/9376	2.01397640050407	ALDH2/ACSL1/HADHB/ALDH9A1/CPT1C/ALDH7A1/ADH5/ALDH3A2/ACADVL/ACADM/ECI2/ACSL4/ADH1B/ACAA2/ACAT2	3.05016413916895
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	25/1624	86/9376	1.67831366708672	MYC/CDKN1B/CAMK2D/SOS2/NCK1/PIK3CA/GSK3B/PRKCA/ABL2/ABL1/PIK3R3/NRAS/MAP2K7/RAF1/SOS1/ELK1/ERBB2/SHC3/MAPK8/PLCG2/MAPK10/PAK4/MAPK9/BRAF/NCK2	2.89230244589694
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/1624	48/9376	1.92446633825944	HMGCS1/ALDH2/HIBCH/HADHB/ALDH9A1/ALDH7A1/DLD/AACS/ALDH3A2/MCEE/AOX1/ACADM/AUH/HIBADH/ACAA2/ACAT2	2.93892985615503
Genetic Information Processing	Transcription	hsa03040	Spliceosome	58/1624	243/9376	1.37801293356849	HSPA1B/HSPA1A/DDX39B/SRSF1/HSPA8/SRSF7/DDX5/SNRPA1/SRSF2/SRSF10/TRA2A/SRSF6/THOC1/HNRNPC/ACIN1/SF3B1/BCAS2/EIF4A3/SF3B3/HNRNPA3/PHF5A/NCBP1/SRSF9/PRPF18/SNRNP40/PPIL1/MAGOHB/NCBP2/CCDC12/SF3A2/THOC5/LSM6/SF3A3/DHX15/LSM5/SNIP1/SNRPA/SRSF5/TRA2B/THOC7/MAGOH/PRPF38A/CWC15/WBP11/SRSF4/SF3B6/LSM8/CHERP/SNW1/DHX16/HNRNPU/SNRPE/SNRPF/THOC3/FUS/LSM2/THOC6/SF3B4	2.73259227287056
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	40/1624	157/9376	1.47092968529384	DUSP5/CALR/ADAM17/ABCA1/SLC16A1/HIF1A/CASP7/ANO6/CAMK2D/ATP2A2/ADAM10/CASP3/CD47/CPT1C/MAPKAPK2/TMEM30A/VPS39/DUSP8/MERTK/CEBPB/PANX1/VPS8/SIRT1/LRP1/RAB5A/GAS6/PBX1/ITGAV/ITGB5/ADAM9/PROS1/LIPA/CASP1/PPARD/NFATC1/UQCRFS1/ODC1/RAB7A/DUSP7/ITGB3	2.72355252100959
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	40/1624	157/9376	1.47092968529384	FAS/ERN1/TNFRSF1A/CASP7/EIF2AK3/CASP3/SREBF1/CYCS/SDHD/NFKB1/PIK3CA/IL6/NDUFC2/NDUFB3/EIF2S1/GSK3B/DDIT3/CXCL8/NDUFB5/PIK3R3/BID/SDHB/MLXIP/NDUFB8/NDUFA9/CASP8/NDUFV2/NDUFA5/MAPK8/MAPK10/UQCRFS1/SDHC/XBP1/NDUFAB1/MAPK9/NDUFA7/MT-CO1/IL1A/CDC42/NDUFB4	2.72355252100959
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	29/1624	106/9376	1.57951482479784	HSP90AA1/NFKBIA/PTEN/PLAU/CDKN1B/PDGFRB/HSP90AB1/PDGFRA/TCF7/SOS2/PLAT/NFKB1/PIK3CA/TP53/AR/GSK3B/HSP90B1/PIK3R3/CREB5/CTNNB1/NRAS/RAF1/SOS1/ERBB2/CREB3L4/MDM2/FGFR1/BRAF/CASP9	2.74630890103296
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	33/1624	125/9376	1.52417733990148	PTEN/TNFRSF1A/BDKRB2/GNAI1/PPP2R2A/CERS2/NFKB1/PIK3CA/TP53/SPTSSA/PRKCA/GNAI3/DEGS1/ORMDL1/S1PR2/PIK3R3/BID/PPP2R1B/ORMDL3/NSMAF/PPP2R3A/PLD1/NRAS/RAF1/S1PR3/PLCB3/PPP2R5A/MAPK8/MAPK10/PPP2CA/GNA12/MAPK9/PPP2R5B	2.70029167315309
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	26/1624	94/9376	1.5968975998323	HSP90AA1/NFKBIA/SRSF1/TBK1/FOSL1/HSP90AB1/TRAF3IP2/CASP3/TNFAIP3/NFKB1/IL6/GSK3B/CEBPB/CXCL8/HSP90B1/TAB3/JUND/CASP8/CXCL2/MAPK8/MAPK10/TRAF6/MAPK9/TRAF4/FADD/CSF3	2.66204103607322
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	19/1624	63/9376	1.74118382985378	ALDH2/DOT1L/SETDB2/ALDH9A1/ALDH7A1/AADAT/EHMT2/NSD1/SETDB1/DLD/DLST/ALDH3A2/SMYD3/KMT5A/TMLHE/PRDM6/PLOD2/EZH2/ACAT2	2.70161325100296
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	32/1624	122/9376	1.51433416781071	MAP3K8/NFKBIA/NFKBIE/PPP3CC/PPP2R2A/SOS2/NCK1/NFKB1/PPP3CB/PIK3CA/GSK3B/BCL10/PIK3R3/PPP2R1B/PPP2R3A/NRAS/MAP2K7/RAF1/SOS1/DLG1/PPP2R5A/CDK4/MAPK8/NFATC1/MAPK10/PAK4/PPP2CA/MAPK9/CDC42/NCK2/CD4/PPP2R5B	2.61717228339888
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	42/1624	170/9376	1.426369168357	GADD45A/MYC/PTEN/MGST1/SMARCD3/GSTM3/TCF7/SMARCE1/SOS2/GADD45B/ARID2/FZD2/WNT2/PIK3CA/ACTL6A/TP53/GSK3B/PRKCA/SMARCA2/GSTA4/LRP6/PIK3R3/CTNNB1/FZD8/NRAS/RAF1/SOS1/ELK1/TXNRD1/NQO1/SHC3/SMAD3/CDK4/PLCG2/GSTT2B/GSTM2/WNT6/GSTM4/CSNK1A1/HGF/BRAF/ARID1B	2.56771333450636
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	13/1624	38/9376	1.97511018926627	UAP1/GFPT2/GNPDA2/GALK2/GFPT1/PGM3/GNPDA1/GNE/GNPNAT1/HEXA/GALT/UGDH/GALE	2.75670520785743
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	48/1624	200/9376	1.3856157635468	NFKBIA/FAS/TNFRSF1A/CASP7/CASP3/NCK1/CYCS/IL1R1/SEC24A/SEC24D/CASP4/NFKB1/ARHGEF11/IL6/ARHGEF2/ARHGEF12/MYO1B/CXCL8/ABL1/ARF6/RAB1A/TNFRSF10B/MYO1E/TAB3/MYH10/ARHGEF1/CTTN/MYD88/CASP8/CASP1/IRAK4/MAPK8/MAPK10/WASF3/GNA12/ARPC5L/NAIP/TRAF6/MAPK9/FADD/RIPK1/CDC42/NCK2/NCL/ARF1/TMED10/ACTR3/CASP9	2.52298601427116
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	33/1624	128/9376	1.48845443349754	NTPCR/PDE4B/AMPD3/PAICS/NUDT9/PPAT/ADCY3/NME1/GART/NT5E/FHIT/PRPS1/NPR1/GMPR2/AMPD2/NT5C2/PDE8A/GMPS/DGUOK/GUCY1A2/PFAS/PDE6D/PDE7A/AK6/PAPSS1/PNP/PRPS2/RRM2B/ATIC/ENPP1/AK9/ADSL/PDE1A	2.54669478388072
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	21/1624	73/9376	1.66084081247048	GADD45A/SOS2/GADD45B/PIK3CA/TP53/PRKCA/PIK3R3/FHIT/NRAS/RAF1/SOS1/ERBB2/RASSF1/CDK4/PLCG2/EML4/STAT3/HGF/BRAF/KIF5A/CASP9	2.59429013779961
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	28/1624	105/9376	1.53957307060755	VCAM1/GADD45A/NFKBIA/PLAU/CYLD/CXCL12/TNFRSF1A/ATM/TNFAIP3/GADD45B/TRIM25/BIRC2/IL1R1/NFKB1/CXCL8/TNFSF14/ERC1/BCL10/TRAF1/TAB3/MYD88/CXCL2/UBE2I/IRAK4/PLCG2/PARP1/TRAF6/RIPK1	2.5447984647495
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/1624	47/9376	1.84257415365266	ALDH2/ALDH9A1/ALDH7A1/ACYP1/FH/ADH5/MDH1/DLD/LDHB/ALDH3A2/ACYP2/ACSS2/ADH1B/ACACA/ACAT2	2.65039915171823
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	13/1624	39/9376	1.92446633825944	MTHFS/MAT2A/ALDH1L2/ALDH7A1/BHMT2/GCSH/DLD/GART/MTHFD2L/SHMT2/MTHFD1/MTHFD2/ATIC	2.64783851445355
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1624	56/9376	1.75263898662913	OSTC/STT3B/ALG2/GANAB/MAN1C1/B4GALT1/DPAGT1/ALG8/ALG14/DDOST/RPN1/DPM1/MAN1A1/MGAT2/ALG5/SRD5A3/DAD1	2.5854999692165
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	38/1624	154/9376	1.42460495169855	MAT2A/ALDH2/RDH11/GCH1/CMPK2/GGCX/NME1/SPR/CPOX/DLD/MTHFD2L/ALDH3A2/PTS/MOCS2/PNPO/ALAS1/SHMT2/NQO1/NADK2/GSS/CTPS1/MTHFD1/HMBS/NFS1/GCLC/RGN/COQ5/NMNAT1/RFK/MTHFD2/HSD17B6/AK6/COQ2/UMPS/UGDH/COX10/AK9/ADSL	2.43166993181875
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	41/1624	169/9376	1.40064709825983	PTEN/ERN1/HIF1A/CALCOCO2/TBK1/VMP1/EIF2AK3/TANK/ATG4C/BIRC6/SUPT20H/ATG16L1/PIK3CA/EIF2S1/VPS39/NRBF2/GORASP2/LAMP2/ATG3/PIK3R3/ATG2B/ATG101/RAB1A/TSC1/NRAS/RAF1/ATG5/ATG4A/EPG5/RPTOR/DDIT4/MAPK8/MAPK10/ATG13/PPP2CA/TRAF6/AMBRA1/MAPK9/RAB7A/C9orf72/MAP1LC3B	2.40557028802788
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1624	57/9376	1.72189093423213	HSD17B4/ACSL1/ELOVL5/SCP2/HADHB/ELOVL6/CPT1C/HACD3/CBR4/ACADVL/ACADM/FADS2/HACD1/ACSL4/ACAA2/ACACA/ACAT2	2.50205083078332
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1624	32/9376	1.98460591133005	HIBCH/ECHDC1/SUCLG2/SUCLA2/SUCLG1/DLD/LDHB/MCEE/ACSS3/ACSS2/ACACA	2.55354068490113
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	33/1624	133/9376	1.4324974999074	SOD2/GADD45A/PTEN/CDKN1B/ATM/CCND2/SOS2/GADD45B/BCL6/RBL2/CAT/PIK3CA/IL6/HOMER1/PLK3/SIRT1/PIK3R3/NRAS/RAF1/SOS1/USP7/G6PC3/SMAD3/MAPK8/MDM2/MAPK10/PLK2/PRMT1/STAT3/MAPK9/CDKN2B/BRAF/SKP2	2.2991892166459
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/1624	105/9376	1.48458831808586	STAT2/IRF1/NFKBIA/CYLD/STAT1/PPP3CC/MAPKAPK2/NFKB1/PPP3CB/PIK3CA/IL6/ARHGEF12/PLK3/BCL10/PIK3R3/NRAS/RAF1/ITPR2/CASP8/CASP1/MAPK8/MDM2/PLCG2/NFATC1/MAPK10/EGR3/MAPK9	2.28547285822081
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1624	50/9376	1.7320197044335	AMD1/L3HYPDH/ALDH2/CNDP2/ALDH9A1/ALDH7A1/ALDH18A1/ALDH3A2/P4HA3/P4HA1/GOT1/OAT/ODC1/SRM/P4HA2	2.37537311515789
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/1624	77/9376	1.57456336766682	GADD45A/MYC/NFKBIA/CDKN1B/SOS2/GADD45B/RUNX1/HDAC1/NFKB1/PIK3CA/TP53/ABL1/PIK3R3/NRAS/RAF1/SOS1/SHC3/SMAD3/CDK4/MDM2/BRAF	2.31705818988676
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	28/1624	110/9376	1.46959247648903	ID2/MYC/BMP2/BAMBI/ID3/ID1/SKP1/SMAD7/HDAC1/ZFYVE16/E2F4/GDF7/FMOD/ID4/PPP2R1B/CUL1/TGIF1/HFE/ACVR1B/SKIL/SMAD3/PPP2CA/SKI/SP1/CDKN2B/BMPR1A/SMAD6/LEMD3	2.26747806021569
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	66/1624	300/9376	1.27014778325123	HSPA1B/HSPA1A/GADD45A/CSF1/MAP3K8/CDC25B/MYC/DUSP5/HSPA8/FGF7/CACNA2D1/FAS/MKNK2/TNFRSF1A/MAP2K3/KITLG/PDGFRB/PDGFRA/PPP3CC/FGF2/DUSP1/SOS2/MAX/CASP3/GADD45B/IL1R1/MAPKAPK2/NFKB1/PPP3CB/TP53/MAP4K3/PRKCA/DUSP8/DDIT3/LAMTOR3/ATF2/MAPKAPK5/MAP3K4/NRAS/MAP2K7/RAF1/JUND/SOS1/ELK1/CACNA1H/MAP3K12/MYD88/ERBB2/IRAK4/VEGFC/MAPK8/NFATC1/MAPK10/CACNA1G/GNA12/PPM1B/TRAF6/MAPK9/PLA2G4C/DUSP7/FGFR1/CACNA1D/HGF/IL1A/BRAF/CDC42	2.17663977282135
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/1624	130/9376	1.42114437286851	COL3A1/NFKBIA/COL4A1/GNAO1/GNAI1/SOS2/NFKB1/PIK3CA/PRKCA/ADCY3/GNAI3/COL4A6/ATF2/PIK3R3/COL4A5/CREB5/GNG4/COL1A1/NRAS/MAP2K7/RAF1/SOS1/COL1A2/COL4A2/PLCB3/CREB3L4/SHC3/VEGFC/MAPK8/MAPK10/MAPK9/EDNRB	2.21308198259504
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1624	42/9376	1.7870044569552	SLC39A14/PRNP/ACSL1/TP53/SLC3A2/SLC11A2/ATG5/NCOA4/GSS/ACSL4/GCLC/LPCAT3/MAP1LC3B	2.33958973604631
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	53/1624	235/9376	1.30208573524788	SMARCD3/MAP2K3/ACSL1/SMARCE1/SOS2/KDM1A/MT-ND4L/SDHD/CPT1C/COA1/NDUFC2/NDUFB3/ACTL6A/ADCY3/COA6/SMARCA2/COX19/MT-ATP8/NDUFB5/ATF2/CREB5/NDUFAF7/TSC1/NPR1/NRAS/SDHB/COX11/SOS1/KDM3B/NDUFB8/NDUFA9/NDUFAF1/RPTOR/COA5/CREB3L4/COA4/MT-ND4/NDUFV2/NDUFA5/SIRT6/UQCRFS1/SDHC/ATP5MC1/ACSL4/NDUFAB1/FGFR1/NDUFA7/MT-CO1/MT-ND5/NDUFAF4/ARID1B/COX10/NDUFB4	2.14654038293497
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	56/1624	253/9376	1.27790650129481	NFKBIA/PPID/RIPK2/CALCOCO2/TBK1/TNFRSF1A/UBE2V1/SKP1/ATM/UBE2N/CYCS/IL1R1/ATG16L1/CGAS/CASP4/NFKB1/PIK3CA/CD44/ELMO2/ARHGEF2/TP53/GSK3B/BTRC/CXCL8/UBE2D1/BCL10/ARF6/PIK3R3/TIFA/CUL1/TAB3/ATG5/VDAC1/CTTN/ITPR2/MYD88/PLCB3/RPTOR/CASP1/MAPK8/MDM2/PLCG2/ACTN1/MAPK10/TLN2/UBE2D3/ARPC5L/NAIP/TRAF6/MAPK9/GLMN/RIPK1/CDC42/MAP1LC3B/ARF1/ACTR3	2.05098223422482
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	21/1624	80/9376	1.51551724137931	PTEN/EIF4E/PDGFRB/PDGFRA/FGF2/SOS2/PIK3CA/IL6/GSK3B/PRKCA/PIK3R3/GAS6/NRAS/RAF1/SOS1/ERBB2/SHC3/PLCG2/STAT3/HGF/BRAF	2.11939497041021
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	39/1624	168/9376	1.3402533427164	STAT2/HSP90AA1/PPID/CYLD/IFNGR1/FAS/STAT1/TNFRSF1A/HSP90AB1/CAMK2D/TNFAIP3/CHMP5/BIRC2/GLUD1/EIF2AK2/AIFM1/DNM1L/TRPM7/IFNGR2/MLKL/BID/TNFRSF10B/VDAC1/PYGL/CASP8/TYK2/CASP1/MAPK8/MAPK10/PARP1/STAT3/SLC25A5/MAPK9/PLA2G4C/FADD/IL1A/PYGM/RIPK1/CHMP7	2.03678953387068
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1624	71/9376	1.54499410254631	MYC/PTEN/GLS/HIF1A/PDGFRB/PDGFRA/PFKM/SLC1A5/PIK3CA/TP53/PDK1/PIK3R3/LDHB/NRAS/RAF1/ERBB2/SIRT6/FGFR1/G6PD	2.10976730113484
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	17/1624	62/9376	1.58302876211664	ADAM17/TLE4/MAML2/TLE1/DTX3L/HDAC1/PSEN1/SPEN/KAT2A/JAG1/SNW1/MAML1/NCSTN/ATXN1/DTX1/DTX2/HEY1	2.10809159436944
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1624	31/9376	1.86238677896075	ACO1/CAT/GCSH/MDH1/DLD/MCEE/SHMT2/PGP/ACSS2/ACAT2	2.20122812188662
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/1624	205/9376	1.29549441307221	COL3A1/PTEN/GFPT2/CAMK2D/ATP2A2/MT-ND4L/SDHD/NFKB1/PIK3CA/NDUFC2/NDUFB3/GSK3B/PRKCA/MT-ATP8/PPP1CC/PPIF/GFPT1/PPP1CB/NDUFB5/PIK3R3/COL1A1/SDHB/NDUFB8/VDAC1/NDUFA9/COL1A2/PLCB3/SMAD3/MT-ND4/NDUFV2/NDUFA5/MAPK8/MAPK10/UQCRFS1/SDHC/ATP5MC1/PARP1/NDUFAB1/SLC25A5/MAPK9/SP1/NDUFA7/G6PD/MT-CO1/MT-ND5/NDUFB4	1.95789603329022
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	29/1624	120/9376	1.3952380952381	NFKBIA/NFKBIE/RIPK2/CAMK2D/SOS2/MAPKAPK2/NFKB1/PIK3CA/TP53/GSK3B/PSEN1/ABL1/PIK3R3/NRAS/MAP2K7/RAF1/SOS1/KIDINS220/MAGED1/SHC3/IRAK4/MAPK8/PLCG2/MAPK10/TRAF6/MAPK9/BRAF/CDC42/IRAK2	1.99438737509108
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	45/1624	201/9376	1.29255201823395	ID2/GADD45A/MYC/PLAU/HOXA11/DDX5/CDKN1B/HOXA10/ATM/CCND2/DOT1L/MAX/GADD45B/NFKBIZ/BIRC2/RUNX1/CCNT2/PRCC/BCL6/RARA/HDAC1/CDK14/PLAT/NFKB1/IL6/TP53/KDM6A/RUNX1T1/MEIS1/TAF15/CEBPB/DDIT3/CXCL8/SUPT3H/TRAF1/PBX1/JMJD1C/PBX3/HOXA9/SS18L1/MDM2/MEN1/SP1/FUS/REL	1.91897739725222
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	21/1624	82/9376	1.47855340622372	HSPA5/HSPA1B/HSPA1A/HSP90AA1/CALR/HSPA8/B2M/HSPA4/PDIA3/HSP90AB1/TAP1/HLA-F/NFYB/PSME2/NFYA/TAP2/CANX/RFX5/KLRC1/HLA-DOB/CD4	1.99208457430196
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	13/1624	45/9376	1.66787082649152	ABCA1/ABCC5/TAP1/ABCC3/ABCA5/ABCA8/ABCD4/TAP2/ABCA6/ABCA9/ABCB5/ABCA10/ABCC4	2.05544757359312
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1624	32/9376	1.80418719211823	ATG4C/ATG16L1/ATG3/ATG2B/ATG101/ATG5/ATG4A/RPTOR/ATG13/PPP2CA	2.08563110349023
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/1624	59/9376	1.56566752943141	GGT5/MGST1/GPX8/GSTM3/GSTA4/GSS/GSTT2B/GSTK1/ODC1/GGCT/GSTM2/SRM/GCLC/GSTM4/G6PD/RRM2B	1.99489929430551
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/1624	78/9376	1.48035872173803	IRF1/CASP7/GNAI1/CASP3/C1S/NFKB1/IL6/GNAI3/CXCL8/C2/MYD88/CASP1/IRAK4/MAPK8/MAPK10/C1R/TRAF6/MAPK9/IL1A/C4B	1.94979961151826
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	29/1624	122/9376	1.37236533957845	SOCS2/STAT1/MAP2K3/SOCS1/GNAI1/SOS2/PIK3CA/GSK3B/PRKCA/ADCY3/GNAI3/ATF2/PIK3R3/CREB5/NRAS/RAF1/SOS1/ITPR2/PLCB3/JUNB/CREB3L4/SHC3/MAPK8/PLCG2/MAPK10/STAT3/MAPK9/CACNA1D/GHR	1.89476862910225
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	36/1624	157/9376	1.32383671676446	SNAI2/TP53BP2/ID2/MYC/BMP2/SAV1/ID1/SMAD7/CCND2/PPP2R2A/TCF7/FZD2/BIRC2/YWHAG/WNT2/GDF7/GSK3B/BTRC/PPP1CC/PPP1CB/MOB1A/SERPINE1/PPP2R1B/CTNNB1/TEAD2/FZD8/DLG1/FRMD6/RASSF1/SMAD3/PPP2CA/WNT6/BMPR1A/AJUBA/BBC3/AMOT	1.87286198743021
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1624	142/9376	1.34170540484285	VCAM1/HSP90AA1/TXN/MGST1/GSTM3/TNFRSF1A/HSP90AB1/DUSP1/SDC4/IL1R1/PLAT/NFKB1/PIK3CA/ARHGEF2/TP53/HSP90B1/GSTA4/PIK3R3/CTNNB1/SUMO4/ITGAV/MAP2K7/SUMO1/NQO1/MAPK8/MAPK10/GSTT2B/GSTM2/MAPK9/GSTM4/ITGB3/IL1A/BMPR1A	1.87790169490512
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	45/1624	203/9376	1.27981751559125	PTEN/LAMA2/COL4A1/PDGFRB/PDGFRA/CCND2/LAMB1/SOS2/BIRC2/PIK3CA/GSK3B/PRKCA/PPP1CC/COL4A6/PPP1CB/PIK3R3/COL4A5/CTNNB1/COL1A1/ITGAV/RAF1/PIP5K1A/ITGB5/SOS1/COL6A1/VTN/ELK1/ITGA6/COL1A2/COL4A2/ERBB2/SHC3/VEGFC/MAPK8/ACTN1/MAPK10/PAK4/TLN2/MAPK9/ITGB3/HGF/BRAF/CDC42/LAMC1/LAMA1	1.84475623617331
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/1624	103/9376	1.40131044048018	COL3A1/LAMA2/COL4A1/LAMB1/CASP3/IL1R1/NFKB1/PIK3CA/IL6/PRKCA/COL4A6/CXCL8/PIK3R3/COL4A5/RAB5A/COL1A1/COL1A2/COL4A2/PLCB3/CXCL2/ACTN1/RAB7A/LAMC1/GNAL/LAMA1	1.87439324110708
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1624	158/9376	1.31545800336721	PTEN/TNFRSF1A/EIF4E/FNIP1/SOS2/LPIN1/FZD2/SESN2/SEC13/WNT2/PIK3CA/GSK3B/PRKCA/SLC3A2/LAMTOR3/WDR59/LRP6/PIK3R3/RICTOR/ATP6V1E2/FZD8/TSC1/CAB39/NRAS/RAF1/SOS1/STRADB/RPTOR/DDIT4/MAPKAP1/ATP6V1C1/TTI1/WNT6/SEH1L/BRAF/SKP2	1.83030518672507
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	24/1624	99/9376	1.3996118823705	HIF1A/PDGFRB/PDGFRA/CHPT1/SOS2/PIK3CA/PRKCA/SLC22A3/PIK3R3/PLD1/TSC1/NRAS/RAF1/PIP5K1A/SOS1/MAPK8/MAPK10/WASF3/CHKA/MAPK9/PLA2G4C/SP1/DGKQ/SLC44A3	1.8294644765234
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1624	56/9376	1.54644616467277	CUL3/CCND2/EVC/GSK3B/BTRC/EFCAB7/CSNK1G3/CUL1/BOC/DISP1/PTCH2/CSNK1A1/SPOPL/HHIP/GAS1	1.8771769294966
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	26/1624	109/9376	1.37714104939666	NFKBIA/PTEN/TNFRSF1A/GFPT2/SREBF1/NFKB1/PIK3CA/IL6/GSK3B/PPP1CC/GFPT1/PPP1CB/PIK3R3/CREB5/SLC27A3/MLXIP/PYGL/G6PC3/CREB3L4/MAPK8/MAPK10/STAT3/PPP1R3C/MAPK9/CRTC2/PYGM	1.81267206225626
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	27/1624	115/9376	1.35549368173056	PDE4B/GNAI1/ARHGEF11/PRKCA/ADCY3/GNAI3/MEF2D/LRP6/ATF2/CREB5/PLD1/RAF1/JUND/OXSR1/ARHGEF1/ITPR2/PTH1R/PLCB3/EGR1/CREB3L4/GNA12/STK39/SP1/FGFR1/MMP14/BRAF/WNK3	1.75559216118059
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1624	76/9376	1.44334975369458	GADD45A/PTEN/PDGFRB/PDGFRA/CAMK2D/SOS2/GADD45B/PIK3CA/TP53/PRKCA/PIK3R3/NRAS/RAF1/SOS1/SHC3/CDK4/MDM2/PLCG2/BRAF	1.77616603940468
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1624	34/9376	1.69805853375833	NFIL3/BHLHE40/SKP1/PER1/BHLHE41/CRY2/BTRC/NR1D1/CUL1/NR1D2	1.86630722088132
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1624	30/9376	1.7320197044335	PIGP/PIGG/PIGK/PIGA/PIGL/PIGF/PIGV/PIGN/PGAP1	1.83798633912327
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1624	77/9376	1.42460495169855	GADD45A/STAT1/GADD45B/NFKB1/PIK3CA/TP53/PIK3R3/PLD1/RAF1/ERBB2/SMAD3/CDK4/MAPK8/MAPK10/STAT3/MAPK9/BRAF/CDC42/CASP9	1.71231658014457
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1624	122/9376	1.32504239683437	MYC/HIF1A/STAT1/PFKM/ATP2A2/HDAC1/PIK3CA/TP53/GSK3B/PRKCA/HDAC3/MED13L/SLC9A1/PIK3R3/KAT2A/CTNNB1/ESR1/ITGAV/NRAS/RAF1/PLCB3/MDM2/PLCG2/THRA/MED30/ITGB3/ATP1A1/CASP9	1.65396741100338
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1624	44/9376	1.57456336766682	OSTC/STT3B/ALG2/MAN1C1/B4GALT1/ALG14/DDOST/RPN1/MAN1A1/MGAT2/HEXA/DAD1	1.74843171303211
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1624	63/9376	1.46626006724529	GTF2H2/POLR2K/POLR2B/CCNH/POLR2C/ERCC3/POLR2A/POLR2M/GTF2H3/ERCC4/RAD23B/GTF2H2C/ERCC8/GTF2H5/ERCC6/RFC2	1.69951680722973
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	31/1624	138/9376	1.29692296708788	SOCS2/MKNK2/EIF4E/SORBS1/SOCS1/SOS2/SREBF1/PIK3CA/PHKG1/GSK3B/PPP1CC/TRIP10/PPP1CB/PIK3R3/TSC1/NRAS/RAF1/SOS1/ELK1/PYGL/SOCS4/G6PC3/RPTOR/SHC3/MAPK8/MAPK10/PPP1R3C/MAPK9/ACACA/BRAF/PYGM	1.60829652874961
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1624	22/9376	1.83699059561129	ALDH2/HNMT/CARNMT1/CNDP2/ALDH9A1/ALDH7A1/ALDH3A2	1.79889164441666
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/1624	83/9376	1.39118048548875	SOD2/HSD17B4/PEX6/ACSL1/PEX13/MPV17/SCP2/FAR1/CAT/ABCD4/GNPAT/NUDT12/CROT/ECI2/GSTK1/ACSL4/PHYH/EPHX2/MPV17L/PEX5	1.63836260798654
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	22/1624	93/9376	1.36575030457122	MAP2K3/CAMK2D/SOS2/PRKCA/ADCY3/PLD1/MAP3K4/NRAS/MAP2K7/RAF1/SOS1/ELK1/ITPR2/PLCB3/EGR1/MAPK8/MAPK10/MAPK9/PLA2G4C/CACNA1D/MMP14/CDC42	1.62238440898143
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	24/1624	103/9376	1.34525802286097	COL3A1/SLC38A2/COL27A1/MME/COL4A1/COL5A2/COL15A1/SLC8A1/SLC1A5/COL7A1/SLC3A2/COL4A6/COL24A1/COL21A1/COL4A5/COL1A1/COL6A1/COL1A2/COL4A2/COL5A1/COL26A1/ACE2/ATP1A1/ELN	1.61259025235991
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/1624	31/9376	1.67614810106468	RPE/PFKM/TKT/PRPS1/RPIA/RGN/DERA/G6PD/PRPS2	1.7258569483375
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	39/1624	181/9376	1.24399205290804	HSPD1/IFNGR1/RIPK2/STAT1/TNFRSF1A/HSPA9/PPP3CC/CAMK2D/CASP3/NFYB/CYCS/NFKB1/PPP3CB/IL6/NFYA/ARHGEF12/CEBPB/PLK3/BCL10/LAMP2/IFNGR2/BID/RAB5A/CASP10/RAF1/MYD88/CASP8/RFX5/IRAK4/MAPK8/MAPK10/TRAF6/MAPK9/RAB7A/HLA-DOB/FADD/IL1A/IRAK2/CASP9	1.51708833971772
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	20/1624	85/9376	1.35844682700666	NTPCR/AMPD3/CMPK2/NME1/NT5E/GMPR2/AMPD2/DUT/NT5C2/CTPS1/GMPS/DGUOK/AK6/PNP/RRM2B/UCK2/ENPP1/AK9/ADSL/UCK1	1.51940916524113
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	21/1624	90/9376	1.34712643678161	SOD2/EIF4E/SESN2/CAT/NFKB1/PIK3CA/EHMT2/TP53/ADCY3/SIRT1/ATF2/PIK3R3/CREB5/ATG101/TSC1/NRAS/ATG5/RPTOR/CREB3L4/ATG13/SESN1	1.51448987425511
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1624	90/9376	1.34712643678161	NFKBIA/PTEN/IFNGR1/NFKBIE/HIF1A/STAT1/MAP2K3/PPP3CC/NFKB1/PPP3CB/PIK3CA/IFNGR2/PIK3R3/NRAS/RAF1/MYD88/NFATC1/EML4/STAT3/TRAF6/CD4	1.51448987425511
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1624	37/9376	1.56037811210225	UAP1/GFPT2/GALK2/GFPT1/PGM3/GNE/GNPNAT1/GALT/UGDH/GALE	1.56316062433244
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1624	37/9376	1.56037811210225	GADD45A/MYC/TCF7/GADD45B/TP53/TFG/CTNNB1/NRAS/NCOA4/BRAF	1.56316062433244
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1624	184/9376	1.22370957378454	TRPC4/CXCL12/NRP1/PPP3CC/UNC5C/CAMK2D/GNAI1/NCK1/RYK/PPP3CB/PIK3CA/SEMA4B/ROBO1/GDF7/GSK3B/PRKCA/GNAI3/ARHGEF12/ABL1/PIK3R3/NRAS/RAF1/SEMA4C/BOC/SLIT3/EFNB1/SSH1/TRPC1/PLCG2/PAK4/ENAH/SSH2/LRIG2/SRGAP1/CDC42/PLXNC1/NCK2/NTN1/PLXNA2	1.40268529040718
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1624	133/9376	1.25886143931257	GNAO1/PPP3CC/CAMK2D/GNAI1/PPP2R2A/PPP3CB/GSK3B/PRKCA/GNAI3/PPP1CC/PPP1CB/ATF2/CREB5/PPP2R1B/GNG4/PPP2R3A/ITPR2/PLCB3/CREB3L4/PPP2R5A/MAPK8/MAPK10/PPP2CA/MAPK9/GRIA4/CACNA1D/GNAL/KIF5A/PPP2R5B	1.37612686778609
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1624	144/9376	1.24288451012589	ID2/MYC/ID3/TBX3/ID1/FGF2/SMARCAD1/TCF7/FZD2/WNT2/PIK3CA/GSK3B/MEIS1/SETDB1/ID4/PIK3R3/CTNNB1/FZD8/PCGF5/JARID2/NRAS/RAF1/ACVR1B/SKIL/SMAD3/STAT3/WNT6/FGFR1/PCGF3/BMPR1A/KLF4	1.34432704401545
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/1624	250/9376	1.17777339901478	VPS26A/VPS13C/AP1G1/OSBP/ARL8B/CLN5/OSTM1/LAPTM4B/IGF2R/SCARB2/CTSC/M6PR/ABCA5/NPC1/CD164/VPS39/BLOC1S6/LAMTOR3/SLC11A2/NAGPA/LAMP2/NCOA7/AP1S1/ATP6V1E2/DMXL2/PIKFYVE/BLOC1S4/NEU1/GALC/GNS/VPS13A/RPTOR/ARSB/LIPA/BLOC1S2/HEXA/ATP6V1C1/CLTCL1/TTI1/HYAL2/CTNS/IDUA/AP1S3/RAB7A/GLA/CLN6/ARL8A/AP3M1/BLOC1S3/AP4M1/ZFYVE26	1.30397215304105
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1624	73/9376	1.34449018152372	TRIM5/CPSF6/MX2/MX1/XPO1/NUP153/ELL/CCNT2/ELL2/BICD1/TNPO3/KAT2A/FEZ1/APOBEC3G/AFF4/CD4/RAN	1.35237936826989
Human Diseases	Cancer: specific types	hsa05218	Melanoma	17/1624	73/9376	1.34449018152372	GADD45A/PTEN/FGF7/PDGFRB/PDGFRA/FGF2/GADD45B/PIK3CA/TP53/PIK3R3/NRAS/RAF1/CDK4/MDM2/FGFR1/HGF/BRAF	1.35237936826989
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1624	68/9376	1.35844682700666	MYC/TCF7/SOS2/RUNX1/RARA/NFKB1/PIK3CA/PIM1/RUNX1T1/PIK3R3/NRAS/RAF1/SOS1/PPARD/STAT3/BRAF	1.35775927446001
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/1624	109/9376	1.27120712252	HSP90AA1/NFKBIA/IFNGR1/NFKBIE/HIF1A/STAT1/HSP90AB1/PPP3CC/RUNX1/IL1R1/RARA/NFKB1/PPP3CB/IL6/IFNGR2/TYK2/SMAD3/MAPK8/NFATC1/MAPK10/STAT3/MAPK9/HLA-DOB/CD4	1.30351648239662
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1624	89/9376	1.29739303702884	LAMA2/COL4A1/LAMB1/SDC4/CD47/AGRN/CD44/COL4A6/COL4A5/COL1A1/ITGAV/ITGB5/COL6A1/VTN/ITGA6/COL1A2/COL4A2/ITGB3/LAMC1/LAMA1	1.29020834092711
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	23/1624	105/9376	1.26464930799906	HIF1A/CALCOCO2/TBK1/MTX2/EIF2AK3/SIAH1/EIF2S1/TP53/RAB5A/NRAS/MAPK8/MAPK10/BCL2L13/CCZ1B/MTX3/AMBRA1/MAPK9/RAB7A/SP1/MAP1LC3B/VCP/MUL1/ARIH1	1.24817043210607
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1624	30/9376	1.53957307060755	ABCC5/ABCC3/NFKB1/IL6/GART/SHMT2/ATIC/ABCC4	1.3547831113412
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	71/1624	362/9376	1.13235174046757	CSF1/HSP90AA1/MYC/PTEN/FGF7/LAMA2/CDKN1B/EIF4E/KITLG/COL4A1/PDGFRB/HSP90AB1/PDGFRA/FGF2/CCND2/MCL1/LAMB1/PPP2R2A/SOS2/OSMR/YWHAG/RBL2/NFKB1/PIK3CA/IL6/TP53/GSK3B/PRKCA/COL4A6/HSP90B1/ATF2/PIK3R3/COL4A5/CREB5/PPP2R1B/GNG4/PPP2R3A/TSC1/COL1A1/ITGAV/PKN2/NRAS/RAF1/ITGB5/SOS1/COL6A1/VTN/ITGA6/COL1A2/COL4A2/G6PC3/RPTOR/DDIT4/ERBB2/CREB3L4/PPP2R5A/VEGFC/CDK4/MDM2/LPAR6/PPP2CA/FGFR1/ITGB3/CRTC2/HGF/CSF3/LAMC1/GHR/LAMA1/PPP2R5B/CASP9	1.1754304411175
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/1624	142/9376	1.21973218622077	CSF1/STAT2/NFKBIA/CYLD/IFNGR1/STAT1/TNFRSF1A/FOSL1/PPP3CC/SOCS1/ATP2A2/IL1R1/NFKB1/PPP3CB/PIK3CA/IFNGR2/PIK3R3/MAP2K7/JUND/ITPR2/JUNB/TYK2/MAPK8/PLCG2/NFATC1/MAPK10/TRAF6/MAPK9/ITGB3/IL1A	1.20757658228721
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1624	12/9376	1.92446633825944	GGCX/NQO1/COQ5/COQ2	1.46663752100001
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1624	21/9376	1.64954257565095	CHST11/DSE/CSGALNACT2/XYLT2/CHST14/CHSY3	1.36385168054876
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1624	70/9376	1.31963406052076	HIF1A/SOS2/PRCC/PIK3CA/VHL/FH/CUL2/PIK3R3/NRAS/RAF1/SOS1/ETS1/PAK4/HGF/BRAF/CDC42	1.22854852967222
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	31/1624	148/9376	1.20929303687924	GADD45A/MYC/PTEN/FGF7/FGF2/TCF7/SOS2/GADD45B/FZD2/WNT2/PIK3CA/TP53/GSK3B/LRP6/PIK3R3/CTNNB1/FZD8/ESR1/NRAS/RAF1/SOS1/JAG1/ERBB2/SHC3/CDK4/WNT6/SP1/FGFR1/CSNK1A1/BRAF/HEY1	1.17463682831259
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1624	60/9376	1.34712643678161	GNAO1/GNAI1/PRKCA/GNAI3/PPP2R1B/NRAS/RAF1/ITPR2/PLCB3/PPP2CA/GNA12/GUCY1A2/PLA2G4C/BRAF	1.23458314702542
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	29/1624	138/9376	1.21325051759834	NFKBIA/TBK1/MAP2K3/NFKB1/PIK3CA/IL6/ELMO2/GSK3B/ARHGEF12/CXCL8/ARF6/PIK3R3/PKN2/MAP2K7/PIP5K1A/ARHGEF1/MYD88/CASP1/IRAK4/MAPK8/NFATC1/MAPK10/ARPC5L/TRAF6/MAPK9/ARHGEF28/CDC42/CD4/ACTR3	1.15508096450471
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/1624	117/9376	1.23363226811503	SMARCD3/MORF4L2/SMARCE1/EPC2/ARID2/HDAC1/GATAD2B/PHF6/GATAD2A/UCHL5/MEAF6/ACTL6A/SMARCA2/INO80/ACTR6/ACTR8/EP400/SS18L1/MTA3/CDK2AP2/BICRA/MRGBP/ING3/ARID1B/CHD4	1.16389950265427
NA	NA	hsa04518	Integrin signaling	32/1624	154/9376	1.19966732774615	VCAM1/LAMA2/COL4A1/PDGFRB/PDGFRA/CCND2/LAMB1/PIK3CA/GSK3B/COL4A6/PIK3R3/COL4A5/CTNNB1/COL1A1/ITGAV/ITGB5/COL6A1/VTN/ITGA6/COL1A2/COL4A2/ERBB2/VEGFC/ACTN1/TLN2/ITGB3/ITGAE/HGF/CDC42/LAMC1/NCK2/LAMA1	1.14347474117919
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/1624	31/9376	1.4899094231686	CSAD/ALDH2/AOC3/HIBCH/CNDP2/ALDH9A1/ALDH7A1/ALDH3A2	1.25048577478837
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1624	71/9376	1.30104766530216	NFKBIA/ADAM17/ADAM10/CASP3/NFKB1/CXCL8/ATP6V1E2/JAM3/CXCL2/MAPK8/PLCG2/ATP6V1C1/MAPK10/MAPK9/GIT1/CDC42	1.16540806105972
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1624	41/9376	1.40814610116545	MYC/TP53/CXCL8/NRAS/RAF1/ERBB2/RASSF1/CDK4/MDM2/BRAF	1.19873224611417
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1624	98/9376	1.23715693173821	PTEN/ITPKC/IP6K3/PIK3CA/MTMR2/PRKCA/SACM1L/PIK3R3/INPP1/PIKFYVE/PI4KB/MTM1/PIP5K1A/IP6K2/ITPR2/PLCB3/PLCG2/IP6K1/OCRL/PIP4P2/DGKQ	1.08017331804238
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1624	27/9376	1.49680715197957	HSD17B4/ELOVL5/SCP2/ELOVL6/HACD3/FADS2/HACD1	1.18320204086145
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1624	13/9376	1.77643046608564	RAD50/XRCC4/LIG4/PRKDC	1.28214900974153
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/1624	109/9376	1.21824015908166	MAP3K8/STAT2/NFKBIA/STAT1/TBK1/MAP2K3/IRF7/NFKB1/PIK3CA/IL6/CXCL8/PIK3R3/MAP2K7/MYD88/CASP8/TYK2/IRAK4/MAPK8/MAPK10/TRAF6/MAPK9/FADD/RIPK1	1.04893869246681
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1624	37/9376	1.40434030089202	GLS/GFPT2/GLUD1/PPAT/GFPT1/NIT2/GOT1/RIMKLB/ADSL	1.12789708151524
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/1624	42/9376	1.37461881304246	ALDH2/ALDH9A1/CAT/ALDH7A1/AADAT/DLD/DLST/ALDH3A2/AOX1/ACAT2	1.11365866124172
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/1624	78/9376	1.25830491347733	PTEN/MINPP1/ITPKC/IP6K3/PIK3CA/MTMR2/SACM1L/INPP1/PIKFYVE/PI4KB/MTM1/PIP5K1A/IP6K2/PLCB3/PLCG2/IP6K1/OCRL	1.0484723127938
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1624	18/9376	1.60372194854953	ABCD4/MMADHC/THAP11/MTRR/ZNF143	1.17341994514829
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1624	110/9376	1.20716524854456	IFNGR1/HIF1A/CDKN1B/MKNK2/EIF4E/CAMK2D/PFKM/NFKB1/PIK3CA/IL6/VHL/PRKCA/CUL2/IFNGR2/PDK1/PIK3R3/SERPINE1/LDHB/TIMP1/PFKFB3/ERBB2/PLCG2/STAT3	1.00031980798758
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1624	23/9376	1.50610409081174	HMGCS1/IDI1/NUS1/ZMPSTE24/FNTA/ACAT2	1.11224398858759
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1624	28/9376	1.44334975369458	ELOVL5/HADHB/ELOVL6/HACD3/HACD1/ACAA2/MBLAC2	1.07532044716066
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1624	59/9376	1.27210486766302	CMPK2/NME1/NT5E/DUT/NT5C2/CTPS1/CDADC1/UMPS/RRM2B/UCK2/ENPP1/AK9/UCK1	0.959612811829026
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	31/1624	155/9376	1.15467980295567	RASD1/CDKN1B/CAMK2D/GNAI1/TCF7/FZD2/WNT2/FH/GSK3B/ADCY3/GNAI3/ATF2/CREB5/CTNNB1/PBX1/FZD8/WDR5/CACNA1H/ITPR2/PLCB3/CREB3L4/CDK4/PDE8A/CACNA1G/LDLR/MEN1/WNT6/SP1/CACNA1D/CDKN2B/BRAF	0.888755327114121
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1624	54/9376	1.28297755883963	MAT2A/AMD1/ADI1/APIP/BHMT2/MDH1/LDHB/MRI1/GOT1/GSS/SRM/GCLC	0.954478378679294
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1624	139/9376	1.16298685189779	HSPA1B/HSPA1A/FKBP4/HSP90AA1/HSPA8/HSP90AB1/GNAO1/GNAI1/SOS2/RARA/GABBR1/PIK3CA/ADCY3/GNAI3/HSP90B1/ATF2/PIK3R3/CREB5/ESR1/NRAS/RAF1/SOS1/ITPR2/PLCB3/CREB3L4/SHC3/SP1/KRT10	0.886066400221424
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1624	44/9376	1.31213613972235	PARG/PARP4/POLG2/NTHL1/LIG3/APTX/APEX1/PARP1/POLB/RFC2	0.949849496479644
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1624	19/9376	1.51931553020482	GNS/ARSB/HEXA/HYAL2/IDUA	1.03707834224295
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1624	29/9376	1.3935790725327	SAV1/FAT4/MOB1A/TEAD2/FRMD6/RASSF1/AJUBA	0.971553329008155
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1624	82/9376	1.19692418599063	MGST1/GSTM3/NME1/GSTA4/DUT/TPMT/CES1/CYP2A7/GMPS/GSTT2B/CDADC1/GSTM2/GSTM4/UMPS/RRM2B/UCK2/UCK1	0.819740551664804
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1624	20/9376	1.44334975369458	HSD17B7/CYP51A1/LSS/LIPA/SQLE	0.908423020927242
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	20/1624	99/9376	1.16634323530875	CDKN1B/SOS2/PIK3CA/TP53/ADCY3/PIK3R3/ESR1/NRAS/RAF1/SOS1/JAG1/ERBB2/SHC3/CDK4/MAPK8/MDM2/MAPK10/MAPK9/SP1/BRAF	0.761536514134942
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1624	99/9376	1.16634323530875	MAP2K3/BDKRB2/CAMK2D/BDKRB1/HTR2A/IL1R1/PIK3CA/HTR2B/PRKCA/ADCY3/PPP1CC/PPP1CB/PIK3R3/ITPR2/PLCB3/MAPK8/PLCG2/MAPK10/MAPK9/PLA2G4C	0.761536514134942
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1624	51/9376	1.24524292475611	PDIA4/PRKCA/ADCY3/ATP6V1E2/PLCG2/ATP6V1C1/KDELR3/ERO1A/SEC61B/ARF1/SEC61A1	0.803764689846876
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1624	62/9376	1.21055140632449	HSPA1B/HSPA1A/SOD2/HSPA8/CAT/HDAC1/PIK3CA/ADCY3/SIRT1/PIK3R3/NRAS/ATG5/RPTOR	0.761303178669804
NA	NA	hsa04981	Folate transport and metabolism	7/1624	31/9376	1.30367074527252	MTHFS/ABCC5/ABCC3/BHMT2/SHMT2/MTHFD1/ABCC4	0.775114601239237
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1624	150/9376	1.11619047619048	GADD45A/MYC/FGF7/CDKN1B/FGF2/TCF7/SOS2/GADD45B/FZD2/WNT2/PIK3CA/TP53/GSK3B/LRP6/PIK3R3/CTNNB1/FZD8/MLH1/NRAS/RAF1/SOS1/ERBB2/SHC3/SMAD3/WNT6/CSNK1A1/HGF/CDKN2B/BRAF	0.656570256352533
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1624	63/9376	1.1913363046368	GADD45A/BMP2/TCF7/GADD45B/FZD2/WNT2/TP53/GSK3B/CTNNB1/FZD8/PTCH2/WNT6/HHIP	0.697420363456509
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/1624	47/9376	1.22838276910177	SOCS2/SOCS1/PIK3CA/PIK3R3/SOCS4/MAPK8/MAPK10/CACNA1G/MAPK9/CACNA1D	0.718400267644486
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1624	21/9376	1.37461881304246	CSAD/ALDH2/AASDHPPT/ALDH3A2/ENPP1	0.786591236488397
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	21/1624	107/9376	1.13309700290042	PPP3CC/CAMK2D/PFKM/CPT1C/PPP3CB/PHKG1/PPP4R3B/SIRT1/ATF2/CREB5/LDHB/PYGL/ITPR2/G6PC3/PLCB3/CREB3L4/PRMT1/CRTC2/ACACA/PYGM/SIK1	0.633746381220039
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1624	69/9376	1.17141429285357	MAP2K3/SOS2/PIK3CA/PRKCA/PIK3R3/NRAS/MAP2K7/RAF1/SOS1/MAPK8/PLCG2/MAPK10/MAPK9/PLA2G4C	0.654091474383882
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1624	69/9376	1.17141429285357	PPP3CC/CAMK2D/HDAC1/PPP3CB/PRKCA/PPP1CC/PPP1CB/SIRT1/ATF2/CREB5/ARC/CREB3L4/GRIA4/CACNA1D	0.654091474383882
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/1624	37/9376	1.2483024896818	VCAM1/FAS/IL6/PRKCA/APOL1/MYD88/PLCB3/THOP1	0.692633538698029
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1624	70/9376	1.15467980295567	LAMA2/SGCB/CASP3/HLA-F/CYCS/ABL2/ABL1/BID/EIF4G2/EIF4G3/CASP8/HLA-DOB/LAMA1/CASP9	0.594528768872642
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1624	65/9376	1.15467980295567	ADCY3/ATF2/CREB5/PBX1/CACNA1H/ITPR2/PLCB3/CREB3L4/PDE8A/CACNA1G/LDLR/SP1/CACNA1D	0.572748412063893
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	13/1624	65/9376	1.15467980295567	TRPC4/GABBR1/PIK3CA/PRKCA/PIK3R3/NRAS/RAF1/CACNA1H/ITPR2/PLCB3/TRPC1/CACNA1G/CACNA1D	0.572748412063893
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1624	60/9376	1.15467980295567	PPP3CC/MAPKAPK2/PPP3CB/PIK3CA/PRKCA/PIK3R3/NRAS/RAF1/PLCG2/PLA2G4C/CDC42/CASP9	0.550131184719935
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/1624	93/9376	1.11743206737645	NFKBIA/IFNGR1/NFKBIE/STAT1/MAML2/PPP3CC/NFKB1/PPP3CB/IFNGR2/JAG1/TYK2/MAML1/MAPK8/NFATC1/MAPK10/MAPK9/HLA-DOB/CD4	0.520901699451388
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1624	33/9376	1.22466039707419	SEC22B/BET1/VTI1A/GOSR2/STX18/STX6/STX5	0.591714328961624
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1624	149/9376	1.08493404304559	GNAO1/GNAI1/MT-ND4L/NDUFC2/GABRE/NDUFB3/PRKCA/ADCY3/GNAI3/NAPEPLD/NDUFB5/GNG4/NDUFB8/NDUFA9/ITPR2/PLCB3/MT-ND4/NDUFV2/NDUFA5/MAPK8/MAPK10/NDUFAB1/MAPK9/NDUFA7/GRIA4/CACNA1D/MT-ND5/NDUFB4	0.478317687189867
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/1624	138/9376	1.08774184336403	CYCS/MT-ND4L/SDHD/NDUFC2/NDUFB3/MT-ATP8/NDUFB5/ATP6V1E2/SDHB/COX11/NDUFB8/NDUFA9/MT-ND4/NDUFV2/NDUFA5/PPA2/ATP6V1C1/UQCRFS1/SDHC/ATP5MC1/NDUFAB1/NDUFA7/MT-CO1/MT-ND5/COX10/NDUFB4	0.475257618137359
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/1624	88/9376	1.11531571876399	PLAU/CFH/BDKRB2/BDKRB1/C1S/PLAT/CFI/C2/F3/SERPINE1/VTN/CD46/PROS1/PROCR/C1R/CFHR3/C4B	0.497439778878211
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1624	28/9376	1.23715693173821	GCH1/SPR/PTS/MOCS2/QDPR/CBR1	0.575211096338319
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1624	122/9376	1.08842768311395	PFKM/PPP2R2A/SREBF1/CPT1C/PIK3CA/SIRT1/PIK3R3/CREB5/PPP2R1B/PPP2R3A/TSC1/CAB39/PFKFB3/STRADB/G6PC3/RPTOR/CREB3L4/PPP2R5A/PPP2CA/CRTC2/ACACA/RAB10/PPP2R5B	0.449961320508993
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1624	23/9376	1.25508674234311	PMS2/MSH6/MSH3/MLH1/RFC2	0.560593563439618
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1624	168/9376	1.06532958010791	SOCS2/STAT2/MYC/IFNGR1/STAT1/PDGFRB/PDGFRA/IL15RA/SOCS1/CCND2/CLCF1/MCL1/SOS2/OSMR/PIK3CA/IL6/PIM1/IFNGR2/PIK3R3/STAM/STAM2/RAF1/SOS1/AOX1/SOCS4/TYK2/IL15/STAT3/CSF3/CISH/GHR	0.391069207296094
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1624	18/9376	1.28297755883963	ACSL1/CBR4/ACSL4/ACACA	0.55000735416289
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1624	101/9376	1.08608496317612	KITLG/GNAO1/CAMK2D/GNAI1/TCF7/FZD2/WNT2/GSK3B/PRKCA/ADCY3/GNAI3/CTNNB1/FZD8/NRAS/RAF1/PLCB3/CREB3L4/WNT6/EDNRB	0.398109732126432
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1624	41/9376	1.12651688093236	AOC3/ALDH7A1/GCSH/DLD/ALAS1/PSPH/SHMT2/GCAT	0.371582294718345
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1624	75/9376	1.07770114942529	HSPA5/PDIA4/GPX8/TTF2/PRKCA/ADCY3/HSP90B1/ATF2/CREB5/CANX/ITPR2/PLCB3/CREB3L4/ATP1A1	0.309218181281447
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	39/1624	217/9376	1.03761549113528	HSP90AA1/MYC/MGST1/FGF7/GSTM3/KPNA2/HSP90AB1/PTGES3/FGF2/GNAI1/SOS2/KPNA4/BCL6/NFKB1/PIK3CA/AR/PRKCA/ADCY3/GNAI3/HSP90B1/GSTA4/ATF2/PIK3R3/CREB5/ESR1/NRAS/RAF1/SOS1/JAG1/CREB3L4/GSTT2B/STAT3/GSTM2/GSTM4/CDC6/CACNA1D/EPHX2/EPHX1/KLF4	0.256592727214461
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	27/1624	149/9376	1.04618639865111	KITLG/PDGFRB/PDGFRA/SOS2/PIK3CA/PRKCA/ADCY3/CXCL8/ARF6/PIK3R3/PLD1/TSC1/NRAS/RAF1/AVPR1A/PIP5K1A/SOS1/PLCB3/DNM1/SHC3/PLCG2/LPAR6/GNA12/PLA2G4C/DGKQ/AGPAT5/ARF1	0.260105024914069
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1624	93/9376	1.05535250807776	SNAI2/SORBS1/TCF7/NECTIN3/PTPRM/FER/SNAI1/CTNNB1/YES1/ERBB2/SMAD3/ACTN1/WASF3/FGFR1/HEG1/CDC42/RADIL	0.245531022068877
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/1624	31/9376	1.11743206737645	ALDH2/ALDH9A1/ALDH7A1/ALDH3A2/RGN/UGDH	0.299743427690108
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	42/1624	238/9376	1.018835120255	CSF1/FGF7/TBK1/RASA3/KITLG/PDGFRB/PDGFRA/FGF2/SOS2/SYNGAP1/NFKB1/PIK3CA/PRKCA/ABL2/ABL1/ARF6/PIK3R3/RAB5A/GNG4/PLD1/NRAS/RAF1/EXOC2/SOS1/ELK1/RASAL2/ETS1/RASSF1/SHC3/VEGFC/MAPK8/PLCG2/MAPK10/PAK4/ETS2/MAPK9/PLA2G4C/FGFR1/HGF/REL/CDC42/BRAP	0.134711002359048
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	42/1624	238/9376	1.018835120255	OAS2/STAT2/NFKBIA/OAS1/ADAM17/MX2/MX1/STAT1/TBK1/TNFRSF1A/RPL22L1/NRP1/C1S/CGAS/NFKB1/PIK3CA/IL6/PRKCA/EIF2AK2/CXCL8/IFIH1/C2/PIK3R3/ADAR/MYD88/ISG15/TYK2/CASP1/RPL36A/ACE2/IRAK4/MAPK8/PLCG2/MAPK10/RSL24D1/STAT3/C1R/TRAF6/MAPK9/CSF3/C4B/RPS10	0.134711002359048
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1624	89/9376	1.03791442962307	PDGFRB/PDGFRA/GNAI1/SOS2/HTR2A/GJA1/HTR2B/PRKCA/ADCY3/GNAI3/NRAS/RAF1/SOS1/ITPR2/PLCB3/GUCY1A2	0.164487756101818
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1624	49/9376	1.06042022720418	POGLUT1/POFUT2/C1GALT1C1/B4GALT1/FUT10/GALNT7/GXYLT1/C1GALT1C1L/GALNT12	0.194080174644109
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/1624	170/9376	1.018835120255	HSPA4/PPP2R2A/MPDZ/WHAMM/RUNX1/RAP2C/ARHGEF2/RAB8B/MSN/MICALL2/PPP2R1B/JAM3/MAP2K7/MYH10/DLG1/CTTN/ERBB2/NEDD4/CDK4/MAPK8/ACTN1/MAPK10/RAB13/PPP2CA/ARPC5L/MAPK9/CACNA1D/CDC42/AMOT/ACTR3	0.113430315850832
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1624	32/9376	1.08251231527094	PFKM/B4GALT1/G6PC3/GALT/GLA/GALE	0.213992777846624
Genetic Information Processing	Translation	hsa03010	Ribosome	39/1624	222/9376	1.01424577286646	RPL22L1/MRPL32/MRPS25/MRPL3/MRPL35/MRPS28/MRPL50/MRPL42/MRPL17/MRPS30/MRPS35/MRPS31/MRPS27/MRPL45/MRPL30/MRPS14/MRPL18/MRPL44/MRPS15/MRPL13/MRPL39/MRPL19/MRPS26/MRPL34/MRPS10/MRPS22/MRPL11/MRPL24/MRPS23/MRPS11/RPL36A/MRPL15/MRPS2/RSL24D1/MRPL9/MRPL4/MRPS17/MRPL14/RPS10	0.09831704511786
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1624	15/9376	1.15467980295567	SLC33A1/ST6GALNAC4/HEXA	0.274403651153064
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/1624	67/9376	1.03404161458716	MINPP1/ALDH2/PFKM/ALDH9A1/ALDH7A1/ADH5/DLD/LDHB/ALDH3A2/G6PC3/ACSS2/ADH1B	0.12798757344779
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	32/1624	183/9376	1.00955611187381	HEATR1/NXF1/XPO1/GNL3/GTPBP4/WDR36/NAT10/UTP14A/WDR3/UTP18/NXT1/MDN1/RIOK2/NOP10/NOP58/XRN2/NOP56/RBM28/IMP3/POP5/GNL3L/BMS1/NVL/WDR75/NMD3/NOB1/RIOK1/UTP6/RPP40/RPP30/AK6/RAN	0.0597516508702772
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	29/1624	166/9376	1.00860585197935	GTF2I/BDKRB2/PPP3CC/GNAI1/ATP2A2/SLC8A1/PPP3CB/ADCY3/GNAI3/PPP1CC/PPIF/PPP1CB/MEF2D/ATF2/CREB5/NPR1/RAF1/VDAC1/ITPR2/PLCB3/CREB3L4/NFATC1/GNA12/GUCY1A2/SLC25A5/RGS2/CACNA1D/ATP1A1/EDNRB	0.0512023471164415
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1624	33/9376	1.04970891177788	IDH3A/ACO1/AADAT/DLD/DLST/GOT1	0.130924167139017
Organismal Systems	Immune system	hsa04611	Platelet activation	22/1624	126/9376	1.00805379623114	COL3A1/GNAI1/PIK3CA/ADCY3/GNAI3/ARHGEF12/PPP1CC/PPP1CB/PIK3R3/COL1A1/ARHGEF1/COL1A2/ITPR2/PLCB3/PLCG2/PTGIR/TLN2/STIM1/GUCY1A2/PLA2G4C/ITGB3/P2RY1	0.0416568869962824
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1624	10/9376	1.15467980295567	SELENBP1/PAPSS1	0.223989830993623
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	40/1624	232/9376	0.995413623237642	FGF7/CXCL12/BDKRB2/PDGFRB/PDGFRA/FGF2/BDKRB1/SOS2/PIK3CA/ARHGEF12/PPP1CC/PPP1CB/SLC9A1/MSN/PIK3R3/PIKFYVE/ITGAV/NRAS/RAF1/PIP5K1A/ITGB5/SOS1/MYH10/ARHGEF1/ITGA6/FGD1/SSH1/ACTN1/PAK4/ENAH/SSH2/GNA12/ARPC5L/FGFR1/ITGB3/ITGAE/BRAF/GIT1/CDC42/ACTR3	-0.0323755668274052
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1624	110/9376	0.997223466188983	CDC25B/HSP90AA1/HSP90AB1/GNAI1/PIK3CA/ADCY3/GNAI3/ANAPC7/PIK3R3/ANAPC1/RAF1/CDC26/MAPK8/MAPK10/ANAPC10/CPEB1/CPEB2/MAPK9/BRAF	-0.0134067937949053
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1624	75/9376	1.00072249589491	MAT2A/RPE/PFKM/IDH3A/ACO1/ALDH18A1/TKT/PRPS1/GOT1/PSPH/SHMT2/RPIA/PRPS2	0.0028752324548569
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1624	52/9376	0.999242137173172	MYLIP/ABCA1/NPC1/STARD3NL/LRP1/VDAC1/LIPA/VAPA/LDLR	-0.00250820433126065
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1624	70/9376	0.98972554539057	NFKBIA/NFKBIE/TNFRSF1A/ACSL1/CPT1C/NFKB1/G6PC3/MAPK8/MAPK10/STAT3/ACSL4/MAPK9	-0.0394909919269362
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1624	41/9376	0.985702270815812	RAD50/ATM/UIMC1/NBN/TOP3A/BABAM2/RAD51B	-0.041992680979566
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1624	23/9376	1.00406939387449	B3GALNT2/POMGNT1/LARGE1/B4GALT1	0.00894313829164795
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1624	23/9376	1.00406939387449	GLS/GLUD1/MDH1/ATP1A1	0.00894313829164795
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1624	53/9376	0.980388511943489	BDKRB2/SLC8A1/PRKCA/ESR1/PTH1R/PLCB3/DNM1/CLTCL1/ATP1A1	-0.0655303381642058
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1624	17/9376	1.018835120255	HSD17B4/SCP2/CYP7B1	0.0355754091058928
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1624	17/9376	1.018835120255	TXNRD1/PAPSS1/SEPHS2	0.0355754091058928
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1624	17/9376	1.018835120255	NRP2/LAMP2/MYH10	0.0355754091058928
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1624	24/9376	0.962233169129721	EXT1/EXTL2/EXT2/XYLT2	-0.0847882523670871
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1624	91/9376	0.951659178260164	NFKBIA/NFKBIE/PPP3CC/SOS2/NFKB1/PPP3CB/PIK3CA/GSK3B/BCL10/PIK3R3/NRAS/RAF1/SOS1/PLCG2/NFATC1	-0.212087727843768
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1624	67/9376	0.947871480038232	PPP3CC/CAMK2D/PPP3CB/PRKCA/PPP1CC/PPP1CB/NRAS/RAF1/ITPR2/PLCB3/BRAF	-0.195989610312059
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1624	61/9376	0.946458854881693	MT1E/MT1X/SLC8A1/SLC11A2/TRPM7/SLC30A1/HEPH/CLCN2/MT2A/ATP1A1	-0.192014007580784
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1624	37/9376	0.93622686726135	AOC3/ADH5/FAHD1/GOT1/AOX1/ADH1B	-0.177893546936384
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1624	12/9376	0.962233169129721	NPC1/CD46	-0.0599159200408532
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/1624	104/9376	0.943728685107995	ETNK1/CHPT1/LPIN1/PLPP5/LPGAT1/GNPAT/SAMD8/PLD1/LPCAT4/PEMT/CHKA/PNPLA7/PLA2G4C/GPD1L/LPCAT3/DGKQ/AGPAT5	-0.264112399118985
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1624	116/9376	0.94564294207576	GLS/SLC38A2/GNAO1/PPP3CC/GNAI1/PPP3CB/PRKCA/ADCY3/GNAI3/HOMER1/GNG4/PLD1/ITPR2/PLCB3/TRPC1/PLA2G4C/GRIA4/CACNA1D/GRIK2	-0.269619446258414
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/1624	98/9376	0.942595757514828	PRKD3/CAMK2D/PRKCA/ADCY3/ATF2/CREB5/NPR1/CACNA1H/ITPR2/PLCB3/CREB3L4/PRKD1/CACNA1G/LDLR/CACNA1D/ATP1A1	-0.261457806105215
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/1624	86/9376	0.939855653568565	CACNA2D1/LAMA2/SGCB/ATP2A2/TCF7/SLC8A1/GJA1/CTNNB1/ITGAV/ITGB5/ITGA6/ITGB3/CACNA1D/LAMA1	-0.256453096452608
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1624	44/9376	0.918495297805643	ADCY3/DYNC2H1/CREB5/RAB5A/DYNLL1/DYNC1H1/CREB3L4	-0.248023828349061
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1624	19/9376	0.911589318122893	GCSH/DLD/DLST	-0.176557021819694
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1624	155/9376	0.931193389480375	SEC22B/CALR/COLEC11/TAP1/HLA-F/M6PR/DYNC2H1/LAMP2/STX12/TAP2/STX18/RAB5A/ATP6V1E2/CANX/PIKFYVE/ITGAV/ITGB5/DYNC1H1/ATP6V1C1/C1R/RAB7A/HLA-DOB/ITGB3/SEC61B/SEC61A1	-0.395347294678872
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	38/1624	233/9376	0.941584388676293	COL3A1/COL27A1/LAMA2/COL4A1/SGCB/COL5A2/SYNPO2/FBLN2/SDC4/AMPD3/AGRN/SYNE1/TMOD2/SDC3/COL4A6/COL24A1/TMEM43/CAPZA1/COL4A5/SUN1/COL1A1/ITGAV/ITGB5/MYH10/COL6A1/ITGA6/COL1A2/AMPD2/COL4A2/COL5A1/FMNL2/TLN2/SPTAN1/NID2/ITGB3/ATP1A1/LAMA1/ELN	-0.413270394924833
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1624	20/9376	0.866009852216749	UAP1/GNE/UGDH	-0.274545624102455
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1624	138/9376	0.92039694438495	SKP1/PPP3CC/CAMK2D/YWHAG/PPP3CB/AR/ADCY3/BTRC/PPP1CC/ANAPC7/PPP1CB/PPP2R1B/CUL1/ANAPC1/ITPR2/PPP2R5A/CDC26/ANAPC10/PPP2CA/CPEB1/CPEB2/PPP2R5B	-0.431173510352445
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1624	65/9376	0.888215233042819	ALDH2/LPIN1/PLPP5/ALDH9A1/ALDH7A1/ALDH3A2/GLA/AGK/DGKQ/AGPAT5	-0.41391666231957
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/1624	133/9376	0.911589318122893	IFNGR1/FAS/PPP3CC/SOS2/CASP3/PPP3CB/PIK3CA/PRKCA/IFNGR2/PIK3R3/BID/TNFRSF10B/NRAS/RAF1/SOS1/SHC3/PLCG2/NFATC1/KLRC1/BRAF/ULBP2	-0.469997829933524
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1624	78/9376	0.888215233042819	PIK3CA/ELMO2/PIK3R3/CTNNB1/CTTN/DNM1/SHC3/CLTCL1/ARPC5L/ARHGAP10/CDC42/ACTR3	-0.453739851746952
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1624	78/9376	0.888215233042819	MARCKSL1/NFKBIA/IFNGR1/STAT1/NFKB1/IFNGR2/ELK1/MYD88/IRAK4/TRAF6/HLA-DOB/IL1A	-0.453739851746952
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1624	97/9376	0.892793662079122	RASD1/GNAO1/CAMK2D/GNAI1/PER1/PRKCA/ADCY3/GNAI3/GNG4/CACNA1H/PLCB3/CACNA1G/GUCY1A2/GRIA4/CACNA1D	-0.485766442234583
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/1624	66/9376	0.874757426481565	IFNGR1/STAT1/NFKB1/IL6/IFNGR2/SMAD3/NFATC1/STAT3/HLA-DOB/IL1A	-0.467327006097415
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1624	79/9376	0.876972002244809	MGST1/GSTM3/ADH5/GSTA4/CBR1/CYP2A7/GSTT2B/GSTK1/GSTM2/ADH1B/GSTM4/EPHX1	-0.502594642506985
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1624	54/9376	0.855318372559752	PMS2/ATR/FAN1/WDR48/MLH1/POLN/ERCC4/TOP3A	-0.488008610117782
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	11/1624	73/9376	0.869964235103583	MGST1/GSTM3/ADH5/GSTA4/AOX1/CYP2A7/GSTT2B/GSTK1/GSTM2/ADH1B/GSTM4	-0.510486786024696
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1624	98/9376	0.883683522670152	MARCKSL1/PIK3CA/PRKCA/ARF6/PIK3R3/PLD1/RAF1/PIP5K1A/PLCG2/WASF3/ARPC5L/PLA2G4C/AMPH/CDC42/ACTR3	-0.529784030934735
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1624	55/9376	0.839767129422302	CERS2/DEGS1/SAMD8/NEU1/GALC/HEXA/GLA/UGCG	-0.545473268713294
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1624	15/9376	0.769786535303777	NTPCR/NFS1	-0.40840118780955
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1624	36/9376	0.801860974274767	C1GALT1C1/ST6GALNAC4/GALNT7/C1GALT1C1L/GALNT12	-0.545154503442206
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1624	69/9376	0.836724494895409	PPP3CC/GNAI1/PPP3CB/GNAI3/NPR1/ITPR2/PLCB3/GUCY1A2/CACNA1D/PDE1A	-0.623035069519341
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1624	50/9376	0.808275862068966	VCAM1/IL6/CXCL8/LRP1/MYD88/HGF/CSF3	-0.62213675398348
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1624	23/9376	0.753052045405869	GLS/GLUD1/GOT1	-0.542707286856322
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1624	23/9376	0.753052045405869	MME/ACE2/THOP1	-0.542707286856322
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1624	76/9376	0.835623541612652	HMGCS1/PLIN2/SORBS1/ACSL1/SCP2/CPT1C/ACADM/FADS2/PPARD/DBI/ACSL4	-0.658531736247114
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1624	89/9376	0.843305474068744	GLS/SLC38A2/GNAO1/GNAI1/GABBR1/GABRE/PRKCA/ADCY3/GNAI3/GNG4/PLCL1/CACNA1D/SLC38A5	-0.67980268251715
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1624	16/9376	0.721674876847291	AOC3/GOT1	-0.509971898628395
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1624	16/9376	0.721674876847291	HEXA/GLA	-0.509971898628395
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/1624	70/9376	0.824771287825475	MGST1/GSTM3/GSTA4/CBR1/CYP2A7/GSTT2B/GSTK1/GSTM2/GSTM4/EPHX1	-0.673510752726514
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1624	44/9376	0.787281683833408	HSPD1/FAS/HLA-F/HLA-DOB/PTPRN2/IL1A	-0.647314936625295
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1624	115/9376	0.853458984793318	GNAO1/GNAI1/DUSP1/CASP3/HTR2A/HTR2B/PRKCA/GNAI3/GNG4/NRAS/RAF1/ITPR2/PLCB3/TRPC1/PLA2G4C/CACNA1D/BRAF	-0.723687285624631
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1624	134/9376	0.861701345489302	ARHGEF11/PRKCA/ADCY3/ARHGEF12/PPP1CC/PPP1CB/NPR1/RAF1/CALCRL/AVPR1A/MYH10/ARHGEF1/ITPR2/PLCB3/PTGIR/GNA12/GUCY1A2/PLA2G4C/CACNA1D/BRAF	-0.738004722111877
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	23/1624	154/9376	0.862260891817542	CACNA2D1/CAMK2D/GNAI1/ATP2A2/PPP2R2A/SLC8A1/PRKCA/ADCY3/GNAI3/PPP1CC/PPP1CB/SLC9A1/ATF2/CREB5/PPP2R1B/PPP2R3A/PLCB3/CREB3L4/PPP2R5A/PPP2CA/CACNA1D/ATP1A1/PPP2R5B	-0.788818044780136
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1624	154/9376	0.862260891817542	CACNA2D1/GNAO1/PPP3CC/CAMK2D/GNAI1/PPP3CB/PRKCA/ADCY3/GNAI3/PPP1CC/PPP1CB/NPR1/NRAS/RAF1/ELK1/ITPR2/PLCB3/NFATC1/GUCY1A2/RGS2/PLA2G4C/CD38/CACNA1D	-0.788818044780136
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1624	45/9376	0.769786535303777	FAS/HLA-F/IL6/KLRC1/HLA-DOB/IL1A	-0.708507826137738
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1624	17/9376	0.679223413503332	GGT5/CSAD	-0.605876582772666
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1624	254/9376	0.886466777859664	FGF7/BDKRB2/PDGFRB/PDGFRA/PPP3CC/ITPKC/FGF2/CAMK2D/ATP2A2/BDKRB1/SLC8A1/HTR2A/PPP3CB/PHKG1/HTR2B/PRKCA/ADCY3/PPIF/AVPR1A/CACNA1H/VDAC1/ITPR2/PLCB3/ERBB2/VEGFC/PLCG2/NFATC1/CACNA1G/STIM1/SLC25A5/FGFR1/MST1/CD38/CACNA1D/HGF/GNAL/MCU/EDNRB/PDE1A	-0.839588645406501
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1624	46/9376	0.753052045405869	FXN/CPOX/ALAS1/HMBS/HEPH/COX10	-0.768449435608729
NA	NA	hsa04517	IgSF CAM signaling	46/1624	299/9376	0.888215233042819	SORBS1/NRP1/UNC5C/TRIO/MPDZ/NCK1/CNTNAP1/PIK3CA/KIRREL1/ROBO1/NECTIN3/GSK3B/PRKCA/NLGN4X/NRP2/ERC1/ABL1/ARF6/MSN/PIK3R3/CTNNB1/DYNLL1/JAM3/NLGN1/MYH10/SLIT3/MAPK8/PLCG2/ACTN1/MAPK10/PAK4/LRFN5/ARPC5L/SPTAN1/TRAF6/MAPK9/FGFR1/ITGB3/SRGAP1/GIT1/CNTN1/CDC42/NCK2/NTN1/ACTR3/PLXNA2	-0.899122406979351
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1624	18/9376	0.641488779419814	NEU1/HEXA	-0.696817827807917
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1624	26/9376	0.666161424782114	SLC19A2/ABCD4/SLC5A6	-0.780169836651899
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/1624	68/9376	0.764126340191249	ALDH1A3/RDH11/ADH5/ALDH1A1/AOX1/CYP2A7/ADH1B/HSD17B6/RDH10	-0.89346487422025
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1624	48/9376	0.721674876847291	PIK3CA/PIK3R3/G6PC3/PLCB3/CACNA1D/ATP1A1	-0.884811031293566
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1624	27/9376	0.641488779419814	HMGCS1/AACS/ACAT2	-0.853834744874313
NA	NA	hsa04519	Cadherin signaling	62/1624	404/9376	0.886016680485783	PCDH18/NFKBIA/SAV1/MAP2K3/PRICKLE2/PDGFRB/PDGFRA/MPDZ/TCF7/ADAM10/RYK/FZD2/YWHAG/NFKB1/WNT2/GJA1/GABRE/GSK3B/FAT4/PSEN1/PPP1CC/MYO1B/PCDHGB6/PPP1CB/MOB1A/PRICKLE1/LRP6/PCDHGB7/PCDHGA12/CTNNB1/TEAD2/FZD8/LHFPL2/MYO1E/NRAS/RAF1/PCDHB7/PCDHGA5/ERBB2/MAPK8/ACTN1/MAPK10/RERE/NCSTN/ENAH/PCDHGA6/ARPC5L/PCDHB14/WNT6/MAPK9/FGFR1/KRT10/CSNK1A1/PCDHGA9/CDH11/PCDHB15/PCDHA10/CDC42/AJUBA/PCDHGA3/FAT1/ACTR3	-1.0719119668611
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1624	49/9376	0.706946818136121	GNAI1/NFKB1/GNAI3/ATF2/CREB5/CREB3L4	-0.941337286335406
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1624	91/9376	0.761327342608131	PDE4B/GNAO1/GNAI1/GABBR1/GABRE/PRKCA/ADCY3/GNAI3/GNG4/PDE8A/PDE7A/PDE1A	-1.04713862493077
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1624	36/9376	0.641488779419814	PYGL/G6PC3/PYGM/ENPP1	-0.986398341863659
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/1624	100/9376	0.750541871921182	CSF1/MME/KITLG/IL1R1/CD44/IL6/ITGA6/HLA-DOB/ITGB3/CD38/IL1A/CSF3/CD4	-1.14786035853881
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/1624	212/9376	0.816990426619574	PRKD3/CSF1/FGF7/ID1/MAP2K3/KITLG/PDGFRB/GNAO1/PDGFRA/FGF2/GNAI1/PIK3CA/PRKCA/ADCY3/GNAI3/PIK3R3/CTNNB1/NRAS/RAF1/PLCB3/PRKD1/VEGFC/TLN2/ENAH/FGFR1/ITGB3/HGF/BRAF/CDC42/P2RY1	-1.23359036162777
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/1624	115/9376	0.753052045405869	GNAO1/CAMK2D/GNAI1/PIK3CA/PRKCA/ADCY3/GNAI3/PIK3R3/CREB5/GNG4/NRAS/ITPR2/PLCB3/CREB3L4/CACNA1D	-1.21954317498568
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1624	38/9376	0.607726212081929	PIK3CA/PRKCA/PIK3R3/ATP1A1	-1.10898563666267
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1624	38/9376	0.607726212081929	TAP1/TAP2/RFX5/CD4	-1.10898563666267
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1624	76/9376	0.68369198859217	CAMK2D/GNAI1/PRKCA/ADCY3/GNAI3/SLC9A1/ITPR2/PLCB3/ATP1A1	-1.26720618016006
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1624	14/9376	0.412385643912737	B4GALT1	-1.00703337846417
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1624	99/9376	0.699805941185252	CACNA2D1/LAMA2/SGCB/ATP2A2/SLC8A1/IL6/ITGAV/ITGB5/ITGA6/ITGB3/CACNA1D/LAMA1	-1.37431941064197
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/1624	140/9376	0.742294159042928	GNAI1/SLC8A1/PLAT/TFAM/ADCY3/GNAI3/SLC9A1/MEF2D/SERPINE1/GNG4/NRAS/RAF1/ITPR2/PLCB3/JAG1/EGR1/SMAD3/MAP1LC3B	-1.40610608082049
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1624	50/9376	0.577339901477833	CXCL12/IL15RA/IL6/IL15/HLA-DOB	-1.37151422126882
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1624	26/9376	0.44410761652141	FADS2/PLA2G4C	-1.29910232731934
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1624	35/9376	0.494862772695285	PFKM/PFKFB3/SORD	-1.37030890759488
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1624	59/9376	0.587125323536779	GNAI1/PIK3CA/ADCY3/GNAI3/PIK3R3/NPR1	-1.45605564728277
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	45/1624	323/9376	0.804343515990788	CDC25B/MYC/PTEN/GLS/PLAU/CDKN1B/ATM/PDGFRB/PDGFRA/SOCS1/CCND2/MCL1/SOS2/CASP3/ZEB2/HDAC1/NFKB1/PIK3CA/CD44/PIM1/TP53/HOXD10/PRKCA/RECK/ABL1/PDCD4/SOX4/SIRT1/PIK3R3/NRAS/RAF1/SOS1/RPTOR/BCL2L2/FSCN1/DDIT4/ERBB2/UBE2I/RASSF1/MDM2/PLCG2/PAK4/STAT3/ITGB3/EZH2	-1.63783826928087
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1624	17/9376	0.339611706751666	GLUD1	-1.24732857465122
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/1624	193/9376	0.747849613313255	STAT2/NFKBIA/CXCL12/STAT1/GNAI1/SOS2/NFKB1/PIK3CA/GSK3B/ADCY3/GNAI3/CXCL8/PIK3R3/GNG4/NRAS/RAF1/SOS1/PLCB3/CXCL2/SHC3/PLCG2/STAT3/CCL26/BRAF/CDC42	-1.62001027649288
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1624	36/9376	0.48111658456486	RPE/SORD/UGDH	-1.42764218028511
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1624	36/9376	0.48111658456486	PRIM2/POLA1/RFC2	-1.42764218028511
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/1624	105/9376	0.65981703026038	CACNA2D1/LAMA2/SGCB/ATP2A2/SLC8A1/ADCY3/ITGAV/ITGB5/ITGA6/ITGB3/CACNA1D/LAMA1	-1.60441123970947
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1624	28/9376	0.412385643912737	ATP6V1E2/ATP6V1C1	-1.42522630695103
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/1624	100/9376	0.635073891625616	CSF1/CXCL12/TNFRSF1A/IL6/ACKR3/CXCL8/TNFSF14/TNFRSF10B/CXCL2/CCL26/TNFRSF10D	-1.67917644866814
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1624	63/9376	0.549847525216983	GGT5/PTGES3/PTGR1/CBR1/PLA2G4C/EPHX2	-1.64080467201435
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1624	86/9376	0.60419292015122	CAMK2D/PRKCA/ADCY3/ATF2/CREB5/PLCB3/CREB3L4/CACNA1D/ATP1A1	-1.6877056157024
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	29/1624	226/9376	0.740834386852086	NFKBIA/PDE4B/CAMK2D/GNAI1/ATP2A2/NFKB1/GABBR1/PIK3CA/ADCY3/GNAI3/PPP1CC/PPP1CB/SLC9A1/PIK3R3/CREB5/PLD1/NPR1/RAF1/CREB3L4/MAPK8/NFATC1/MAPK10/MAPK9/GRIA4/CACNA1D/ATP1A1/BRAF/HHIP/ABCC4	-1.80506488925951
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/1624	116/9376	0.647018855104467	VCAM1/CXCL12/GNAI1/PIK3CA/PRKCA/GNAI3/MSN/PIK3R3/CTNNB1/JAM3/PLCG2/ACTN1/CDC42	-1.75084127914058
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1624	39/9376	0.44410761652141	FAS/HLA-F/HLA-DOB	-1.59217615823337
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1624	102/9376	0.622621462378055	ATP2A2/RAB27B/PRKCA/ADCY3/SLC9A1/ITPR2/BST1/PLCB3/TRPC1/CD38/ATP1A1	-1.75394312308757
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1624	48/9376	0.48111658456486	IST1/LAMP2/LDLR/CHMP7	-1.64955920878328
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/1624	95/9376	0.607726212081929	CSF1/CXCL12/IL6/CXCL8/ATP6V1E2/CXCL2/ATP6V1C1/IL15/HLA-DOB/IL1A	-1.75883651790908
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1624	51/9376	0.452815609002222	CHPT1/PLD1/LPCAT4/PLA2G4C	-1.79335445765363
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1624	52/9376	0.44410761652141	HSD17B7/ADCY3/LDLR/PLA2G4C	-1.83976787697954
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1624	93/9376	0.558716033688225	PRKCA/ADCY3/SLC9A1/ITPR2/BST1/PLCB3/GUCY1A2/CD38/ATP1A1	-1.95743439699121
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1624	87/9376	0.530887265726742	CACNA2D1/ATP2A2/SLC8A1/SLC9A1/UQCRFS1/CACNA1D/ATP1A1/MT-CO1	-2.01198220706763
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1624	160/9376	0.613423645320197	VCAM1/HLA-F/SDC4/NRXN2/CNTNAP1/NECTIN3/CD276/NLGN4X/SDC3/PTPRM/JAM3/ITGAV/NLGN1/ITGA6/HLA-DOB/CNTN1/CD4	-2.25733395009861
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1624	28/9376	0.206192821956369	B4GALT1	-1.92533565777337
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1624	41/9376	0.281629220233089	GABRE/GRIA4	-2.10986755946912
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1624	30/9376	0.192446633825944	PLA2G4C	-2.0276394831333
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1624	43/9376	0.268530186733876	ABCA1/ACAT2	-2.2003500201778
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1624	90/9376	0.44904214559387	ABCC3/ADCY3/SLC9A1/LDLR/ATP1A1/EPHX1/ABCC4	-2.4037929792261
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1624	54/9376	0.320744389709907	FAS/HLA-F/HLA-DOB	-2.29111734611413
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1624	99/9376	0.466537294123501	CFH/C1S/CFI/C2/C1R/KRT10/HLA-DOB/C4B	-2.44224737303043
Human Diseases	Immune disease	hsa05310	Asthma	1/1624	32/9376	0.180418719211823	HLA-DOB	-2.12555512920789
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1624	66/9376	0.349902970592626	HSD17B7/SRD5A3/HSD17B6/CYP7B1	-2.42575579446274
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/1624	79/9376	0.365405000935337	ATP6V1E2/DNM1/ATP6V1C1/CLTCL1/CPLX1	-2.5924509258964
Human Diseases	Substance dependence	hsa05034	Alcoholism	18/1624	191/9376	0.544089959507905	GNAO1/GNAI1/SOS2/HDAC1/GNAI3/HDAC8/PPP1CC/HDAC3/PPP1CB/ATF2/CREB5/GNG4/NRAS/RAF1/SOS1/CREB3L4/SHC3/BRAF	-2.91358725492107
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1624	86/9376	0.335662733417344	GABBR1/SCN2A/PLCB3/PDE1A/P2RY1	-2.83270763110224
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/1624	194/9376	0.505916408511503	MYO1B/DYNC2H1/CAPZA1/TUBG1/DYNLL1/MYO1E/ACTR10/MYH10/DYNC1H1/DYNLT3/KIF2A/KIF9/KIF27/DNAH14/DNAH11/DYNLT1/KIF5A	-3.18276387870615
NA	NA	hsa04081	Hormone signaling	20/1624	219/9376	0.527251051577929	GNAO1/GNAI1/PIK3CA/ADCY3/GNAI3/PIK3R3/GNG4/ESR1/ITGAV/NPR1/AVPR1A/PTH1R/PLCB3/STAT3/GNA12/HEPH/THRA/ITGB3/BMPR1A/GHR	-3.24002074162003
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/1624	298/9376	0.581214665917281	CSF1/BMP2/IFNGR1/CXCL12/FAS/TNFRSF1A/IL15RA/CLCF1/OSMR/IL1R1/IL6/GDF7/ACKR3/CXCL8/TNFSF14/RELT/IFNGR2/TNFRSF12A/TNFRSF10B/ACVR1B/CXCL2/IL15/GDF11/CCL26/IL1A/BMPR1A/CSF3/CD4/GHR/TNFRSF10D	-3.36260826182759
NA	NA	hsa04082	Neuroactive ligand signaling	17/1624	199/9376	0.493204940960962	GNAO1/GNAI1/HTR2A/OGFR/GABBR1/GABRE/HTR2B/PRKCA/ADCY3/GNAI3/GNG4/PLCB3/SLC17A9/GRIA4/GNAL/GRIK2/P2RY1	-3.30735119239651
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1624	195/9376	0.47371479095617	HDAC1/CASP4/NFKB1/PIK3CA/PRKCA/HDAC8/PPIF/HDAC3/PIK3R3/RAF1/VDAC1/PLCB3/CASP1/PLCG2/SLC25A5/ITGB3	-3.39911020353129
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1624	143/9376	0.322987357470116	C1S/C2/TRIM21/SSB/ACTN1/C1R/HLA-DOB/C4B	-3.73392119930659
NA	NA	hsa04382	Cornified envelope formation	16/1624	217/9376	0.4256884066196	COL4A1/PPP2R2A/KAZN/COL7A1/COL4A6/COL4A5/PPP2R1B/PPP2R3A/ITGA6/COL4A2/PPP2R5A/PPP2CA/KRT10/UGCG/EPHX2/PPP2R5B	-3.91764599022248
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	21/1624	370/9376	0.327679403541473	BDKRB2/BDKRB1/HTR2A/OGFR/GABBR1/GABRE/HTR2B/S1PR2/PGRMC1/CALCRL/AVPR1A/S1PR3/PTH1R/PTGIR/LPAR6/THRA/GRIA4/GHR/EDNRB/GRIK2/P2RY1	-6.03925093711438
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1624	449/9376	0.0771500981930288	CAMK2D/SLC8A1/ADCY3/RGS2/GNAL/PDE1A	-9.1721942159444