category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	86/1958	174/9376	2.36675941906473	OSTC/SSR3/PDIA6/SEC61B/CALR/HSPA5/HERPUD1/SKP1/HSPA1B/SEC61G/HSPA8/DAD1/DNAJA1/HSPH1/CANX/EDEM2/BAG2/HSPA1A/EDEM3/SSR2/AMFR/DERL2/DDOST/PDIA3/SEC24D/STT3B/EIF2AK3/SEC23B/DNAJB11/UBE2D1/TRAM1/UBXN8/SAR1B/UBQLN2/DNAJC3/CAPN2/ERN1/HSP90AB1/UFD1/RAD23B/P4HB/SEC24A/SYVN1/UBE2G1/EIF2S1/PREB/PLAA/DERL1/UBE2J2/HYOU1/ERO1A/MAPK10/MAN1A1/RBX1/SEC23A/SEC24C/DDIT3/PDIA4/FBXO6/XBP1/UBE2J1/BCL2/DNAJA2/MOGS/RPN1/ERO1B/TUSC3/RNF5/MAN1C1/BCAP29/SEC13/STT3A/SEC24B/UGGT1/LMAN2/RAD23A/EDEM1/MAPK8/MAPK9/ATF6B/UBQLN1/HSPA4L/TRAF2/UBE2D4/UGGT2/LMAN1	9.34919359013678
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	64/1958	142/9376	2.15822411486282	SKP1/SOCS3/UBE2N/CDC26/UBE2B/FANCL/UBE2L6/ELOC/CUL2/SOCS1/UBE2D1/HERC4/SIAH1/CUL3/UBA2/UBA3/RNF7/UBE2M/UBE2H/UBE2A/RCHY1/UBA6/SYVN1/UBE2G1/UBE2Q1/UBE2S/UBE2W/UBE2J2/ANAPC13/UBE2Z/UBE2E3/CDC27/UBE2F/CUL4B/CDC23/ANAPC10/UBE2I/ANAPC7/MDM2/RBX1/KLHL9/UBE2J1/UBE2E1/TRAF6/KLHL13/SAE1/ANAPC4/UBC/UBE2Q2/COP1/HERC3/UBE3C/NEDD4/CUL4A/KEAP1/UBE2L3/TRIM32/SKP2/UBE2D4/BTRC/PIAS2/FBXO4/CDC16/BIRC6	7.14480544716515
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	134/1958	388/9376	1.65378094626328	SDHD/DKK1/PSMA2/FAS/NDUFA4/NDUFB3/NDUFB5/PSMA5/TUBA3D/PSMA3/NDUFC2/CALM2/MME/COX7A2L/SDHC/NDUFV2/PPID/NAE1/PSMB2/AKT1/ATP5MC3/EIF2AK3/TNFRSF1A/CASP3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/CASP7/PSMB3/PSMD12/PSMB5/CTNNB1/VDAC1/PPIF/CAPN2/NDUFB8/UQCRFS1/VDAC2/SLC39A14/ERN1/NDUFA9/SLC39A1/NDUFA8/CYCS/SLC25A5/CASP8/NDUFS4/NDUFB6/NDUFS3/RTN3/ATP2A2/ADAM17/PSMC4/BID/EIF2S1/PSMC2/APH1B/FZD2/VDAC3/UQCRC2/COX6C/WNT6/UQCRH/NCSTN/PSMA1/CSNK2B/FZD1/PSMB1/PSMD9/IL1A/MAPK10/CSF1/NRBF2/SLC39A6/FADD/MCU/ATG101/PIK3R3/DDIT3/PSMC6/MAP2K1/PIK3R4/IDE/XBP1/PPP3R1/MAP2K2/WIPI1/ATP5PB/PIK3CA/NDUFB4/PSMD6/COX8A/CSNK2A2/PLCB3/COX6A1/MAPK1/SLC11A2/PIK3C3/ATP5PO/PPP3CB/SLC39A2/HSD17B10/TUBB2A/NFKB1/ATP5MC1/WNT2/ATP5PF/SDHA/BECN1/MAPK8/NRAS/NDUFA5/CACNA1D/MAPK9/EIF2AK2/COX7B/KRAS/PSENEN/SLC39A3/TRAF2/TUBB6/PPP3CC/PSMB4/GSK3B/ADAM10/LPL/PSMA4/DVL3/FZD8/NDUFA12/CHUK/ATG2B	6.75717486224516
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	128/1958	368/9376	1.66558600168761	ACTG1/SDHD/PSMA2/NDUFA4/NDUFB3/HSPA5/NDUFB5/PSMA5/TUBA3D/PSMA3/NDUFC2/CAT/COX7A2L/HNRNPA2B1/SDHC/NXT1/ANXA7/SRSF7/NDUFV2/TANK/TBK1/PSMB2/ACTR10/ATP5MC3/MAP1LC3B/EIF2AK3/TNFRSF1A/CASP3/PFN2/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/PSMB3/PSMD12/PSMB5/DCTN6/NUP54/UBQLN2/NUP160/VDAC1/NDUFB8/UQCRFS1/ERN1/NDUFA9/C9orf72/NUP153/NDUFA8/CYCS/GPX8/NDUFS4/NDUFB6/NDUFS3/PSMC4/BID/EIF2S1/PSMC2/HNRNPA3/NUP98/UQCRC2/COX6C/DERL1/UQCRH/PSMA1/ALYREF/WDR41/RAB1A/PSMB1/NXT2/PSMD9/NUP205/SETX/SPG11/NRBF2/PFN1/MCU/ATG101/DDIT3/PSMC6/PIK3R4/XBP1/NUP37/RAE1/NUP58/PPP3R1/WIPI1/ATP5PB/BCL2/NDUFB4/PSMD6/COX8A/DNAH11/RAB8A/ATXN2L/MAP2K3/COX6A1/SEC13/CHMP2B/PIK3C3/HNRNPA1/DNAL4/ATP5PO/PPP3CB/ACTR1B/TUBB2A/NUP35/ATP5MC1/NUP50/NCBP1/ATP5PF/SDHA/BECN1/NDUFA5/NUP133/COX7B/UBQLN1/FIG4/TRAF2/TUBB6/PPP3CC/PSMB4/PSMA4/NUP43/SOD1/NDUFA12/ATG2B/NUP107	6.69210070127271
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	98/1958	268/9376	1.75104050737121	TXN/SDHD/DUSP1/PSMA2/NDUFA4/NDUFB3/HSPA5/SNCAIP/NDUFB5/PSMA5/TUBA3D/PSMA3/NDUFC2/CALM2/COX7A2L/SDHC/NDUFV2/PSMB2/ATP5MC3/UBE2L6/EIF2AK3/CASP3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/HTRA2/PSMB3/PSMD12/GNAI3/MAOB/PSMB5/VDAC1/PPIF/NDUFB8/UQCRFS1/VDAC2/SLC39A14/ERN1/NDUFA9/SLC39A1/NDUFA8/CYCS/SLC25A5/NDUFS4/NDUFB6/NDUFS3/PSMC4/UBE2G1/EIF2S1/PSMC2/VDAC3/UQCRC2/COX6C/UBE2J2/UQCRH/PSMA1/PARK7/PSMB1/PSMD9/MAPK10/SLC39A6/MCU/UCHL1/DDIT3/PSMC6/GNAI1/MFN1/XBP1/UBE2J1/ATP5PB/NDUFB4/CAMK2D/PSMD6/COX8A/COX6A1/SLC11A2/GNAS/ATP5PO/UBC/SLC39A2/TUBB2A/ATP5MC1/ATP5PF/SDHA/MAPK8/NDUFA5/MAPK9/COX7B/SLC39A3/KEAP1/TUBB6/UBE2L3/PSMB4/PSMA4/SOD1/NDUFA12	6.40866860763635
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	152/1958	480/9376	1.5163772557031	SDHD/DKK1/PSMA2/FAS/NDUFA4/NDUFB3/HSPA5/SNCAIP/NDUFB5/PSMA5/TUBA3D/PSMA3/NDUFC2/CAT/CALM2/IFT57/COX7A2L/SDHC/NDUFV2/TANK/TBK1/PPID/PSMB2/ACTR10/ATP5MC3/MAP1LC3B/UBE2L6/EIF2AK3/TNFRSF1A/CASP3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/HTRA2/CASP7/PSMB3/PSMD12/PSMB5/CTNNB1/DCTN6/VDAC1/PPIF/CAPN2/NDUFB8/UQCRFS1/VDAC2/ERN1/NDUFA9/C9orf72/NDUFA8/CYCS/GPX8/SLC25A5/CASP8/NDUFS4/NDUFB6/NDUFS3/ATP2A2/PSMC4/BID/UBE2G1/EIF2S1/PSMC2/FZD2/VDAC3/UQCRC2/PRNP/COX6C/DERL1/WNT6/UBE2J2/PRKCA/UQCRH/PSMA1/CSNK2B/WDR41/RAB1A/FZD1/PARK7/PSMB1/PSMD9/IL1A/MAPK10/CSF1/SPG11/NRBF2/FADD/MCU/ATG101/UCHL1/DDIT3/PSMC6/MAP2K1/MFN1/PIK3R4/XBP1/GRIA3/PPP3R1/UBE2J1/MAP2K2/WIPI1/ATP5PB/BCL2/NDUFB4/CAMK2D/PSMD6/COX8A/CSNK2A2/DNAH11/RAB8A/PLCB3/ATXN2L/MAP2K3/COX6A1/MAPK1/CHMP2B/PIK3C3/DNAL4/ATP5PO/UBC/PPP3CB/ACTR1B/HSD17B10/TUBB2A/NFKB1/ATP5MC1/WNT2/ATP5PF/SDHA/BECN1/MAPK8/NRAS/NDUFA5/CACNA1D/MAPK9/COX7B/KRAS/FIG4/TRAF2/TUBB6/PPP3CC/UBE2L3/PSMB4/GSK3B/PSMA4/DVL3/SOD1/FZD8/NDUFA12/ATG2B	5.9667645955968
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	66/1958	169/9376	1.87008842497174	RHEB/ATG5/TANK/TBK1/ATG4C/AKT1/PTEN/MAP1LC3B/EIF2AK3/CALCOCO2/RRAS/VMP1/LAMP2/ERN1/C9orf72/DDIT4/GABARAPL2/RAB7A/EIF2S1/LAMP1/WDR41/RAB1A/MAPK10/RRAGC/RRAGA/STK11/NRBF2/HIF1A/ATG101/SUPT20H/PIK3R3/MAP2K1/GORASP2/ATG16L1/PPP2CB/PIK3R4/STX17/PRKCD/MAP2K2/ATG4A/WIPI1/PRKAA1/PIK3CA/BCL2/TRAF6/RAB8A/STX7/MAPK1/PIK3C3/RPS6KB1/UBC/RRAGB/BNIP3/ATG3/DEPTOR/BECN1/MAPK8/NRAS/MAPK9/KRAS/EPG5/RAB33B/VPS11/ATG2B/MTMR14/BIRC6	5.86403075425846
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	82/1958	227/9376	1.72978810527689	MGST1/SOD2/SDHD/NDUFA4/NDUFB3/NDUFB5/GSTO1/NDUFC2/CAT/NQO1/COX7A2L/MGST3/SDHC/NDUFV2/AKT1/PRKD3/ATP5MC3/PTEN/NFKBIA/SDHB/NDUFA7/NDUFAB1/ATP5F1C/VDAC1/PPIF/NDUFB8/UQCRFS1/VDAC2/NDUFA9/NDUFA8/SLC25A5/NDUFS4/NDUFB6/NDUFS3/VDAC3/UQCRC2/COX6C/UQCRH/ABL1/MAPK10/HIF1A/SOS2/GSTM3/PIK3R3/MAP2K1/CBR1/PRKCD/MAP2K2/ATP5PB/PIK3CA/NDUFB4/PTK2/PRKD1/COX8A/ACP1/COX6A1/MAPK1/ARNT/ATP5PO/GSTM5/NFKB1/EPHX2/ATP5MC1/ATP5PF/SDHA/MAPK8/NRAS/SOS1/NDUFA5/GSTT2B/MAPK9/COX7B/KRAS/PLD1/KEAP1/GSTA4/AKR1C2/SOD1/GSTM2/PTPN11/NDUFA12/CHUK	5.71835960329789
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	46/1958	108/9376	2.03957174743692	RAN/EIF4A3/SUMO2/SUMO1/NXT1/DDX39B/NUP54/NUP160/NUP153/XPOT/KPNA2/NUP98/ALYREF/MAGOHB/NXT2/NUP205/TMEM33/EEF1A1/UBE2I/PYM1/NUP37/THOC7/RAE1/NUP58/XPO5/IPO11/SEC13/MAGOH/AHCTF1/THOC6/THOC1/NUP35/NUP50/NCBP1/RANBP17/IPO4/NUP133/XPO1/THOC3/XPO7/TNPO1/XPO4/NUP43/RNPS1/KPNA4/NUP107	5.58241219372102
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	92/1958	275/9376	1.601990899805	SDHD/PSMA2/NDUFA4/NDUFB3/HSPA5/NDUFB5/HSPA1B/HSPA8/PSMA5/TUBA3D/PSMA3/NDUFC2/COX7A2L/HSPA1A/SDHC/NDUFV2/PSMB2/ATP5MC3/EIF2AK3/CASP3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/PSMB3/PSMD12/PSMB5/VDAC1/PPIF/NDUFB8/UQCRFS1/VDAC2/NDUFA9/CAV2/NDUFA8/CYCS/ATF2/SLC25A5/NDUFS4/NDUFB6/NDUFS3/STIP1/PSMC4/EIF2S1/PSMC2/VDAC3/UQCRC2/PRNP/COX6C/UQCRH/PSMA1/CSNK2B/PSMB1/PSMD9/IL1A/MAPK10/MCU/PIK3R3/DDIT3/PSMC6/PPP3R1/PRKCD/ATP5PB/PIK3CA/NDUFB4/PSMD6/COX8A/CSNK2A2/COX6A1/MAPK1/ATP5PO/PPP3CB/TUBB2A/ATP5MC1/ATP5PF/SDHA/FYN/MAPK8/NDUFA5/CACNA1D/MAPK9/COX7B/ATF6B/TUBB6/CREB3L4/PPP3CC/PSMB4/GSK3B/PSMA4/SOD1/NDUFA12	5.20547402025311
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	37/1958	83/9376	2.13465916782554	SOD2/SCP2/CAT/PRDX1/NUDT12/PEX13/PEX7/PEX5/HSD17B4/PEX3/NUDT7/ECI2/PEX2/CROT/FAR1/GSTK1/ABCD3/MPV17L2/PHYH/ECH1/PEX12/ACSL1/AGPS/EPHX2/ACOX1/PEX19/MPV17/PXMP4/HACL1/EHHADH/ACSL5/FAR2/SOD1/PMVK/DECR2/MLYCD/PEX10	5.33427094992562
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	59/1958	157/9376	1.79952245564498	SDHD/FAS/NDUFA4/NDUFB3/NDUFB5/SOCS3/CDC42/NDUFC2/COX7A2L/SDHC/NDUFV2/AKT1/EIF2AK3/TNFRSF1A/CASP3/SDHB/NDUFA7/NDUFAB1/CASP7/CXCL8/NDUFB8/UQCRFS1/ERN1/NDUFA9/NDUFA8/CYCS/CASP8/MLX/NDUFS4/NDUFB6/NDUFS3/BID/EIF2S1/ADIPOR1/UQCRC2/COX6C/UQCRH/IL1A/MAPK10/PIK3R3/DDIT3/XBP1/PRKAA1/PIK3CA/NDUFB4/COX8A/COX6A1/SREBF1/NFKB1/SDHA/MAPK8/NDUFA5/MAPK9/COX7B/TRAF2/PRKAG1/PRKAB1/GSK3B/NDUFA12	5.190236555444
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/1958	56/9376	2.39427987742594	OSTC/DAD1/MGAT2/ALG5/DDOST/STT3B/ALG14/DPM1/ALG2/ALG1/ALG13/MGAT4B/DPAGT1/MAN1A1/B4GALT3/ALG6/FUT8/MOGS/RPN1/ALG8/TUSC3/MAN1C1/STT3A/SRD5A3/DOLPP1/DOLK/MGAT4C/B4GALT1	5.37631349087811
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	99/1958	308/9376	1.53917992120239	SOD2/SDHD/PSMA2/NDUFA4/NDUFB3/NDUFB5/PSMA5/TUBA3D/PSMA3/NDUFC2/IFT57/COX7A2L/SDHC/NDUFV2/PSMB2/ACTR10/CLTA/ATP5MC3/CASP3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/PSMD11/PSMB3/PSMD12/TBPL1/POLR2C/PSMB5/POLR2B/DCTN6/VDAC1/PPIF/POLR2K/NDUFB8/UQCRFS1/VDAC2/ERN1/NDUFA9/NDUFA8/CYCS/GPX8/SLC25A5/CASP8/NDUFS4/NDUFB6/NDUFS3/POLR2H/PSMC4/PSMC2/VDAC3/UQCRC2/COX6C/UQCRH/PSMA1/PSMB1/PSMD9/MAPK10/NRBF2/ATG101/HDAC1/PSMC6/PIK3R4/GRIA3/WIPI1/ATP5PB/NDUFB4/PSMD6/COX8A/DNAH11/PLCB3/COX6A1/PIK3C3/DNAL4/ATP5PO/ACTR1B/TUBB2A/ATP5MC1/POLR2D/TFAM/ATP5PF/SDHA/BECN1/MAPK8/NDUFA5/MAPK9/COX7B/AP2M1/TRAF2/TUBB6/CREB3L4/TGM2/POLR2J/PSMB4/TAF4/PSMA4/SOD1/NDUFA12/ATG2B	4.94312827787515
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	82/1958	248/9376	1.58331411249135	TXN/MYC/ACTG1/MYL12B/DYNLL1/SKP1/RIPK2/ARF1/ARPC3/DYNLT3/TUBA3D/CDC42/ARPC1A/RAB9A/RHOB/ACTR10/AKT1/MYL12A/M6PR/TLR4/NFKBIA/TNFRSF1A/CASP3/PFN2/CASP7/ANXA2/CXCL8/CTNNB1/DCTN6/ARL8A/DYNLT1/RRAS/PAK3/HSP90AB1/ACBD3/CYCS/CASP8/DYNC2LI1/BRK1/RAB7A/ACTR3/ARPC5L/MYD88/ARL8B/MAPK10/EXOC5/PFN1/FADD/MLKL/MAP2K1/ARPC5/STX10/MAP2K2/ARPC1B/WASF3/PIK3CA/BCL2/IRAK4/TRAF6/MAP2K3/EXOC2/ARF6/SNX18/MAPK1/RHOA/PIK3C3/ACTR1B/TUBB2A/NFKB1/MAPK8/MAPK9/FBXO22/TRAF2/TUBB6/WASL/VPS11/TRADD/CASP4/RALA/CHUK/ELMO2/KPNA4	4.78287549660426
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	57/1958	157/9376	1.73852169443667	MYC/SERPINE1/GADD45A/RHEB/CALM2/PPP1CB/CHEK2/PPID/AKT1/PTEN/GADD45G/CXCL8/ZFP36L1/HLA-F/PPP1CC/VDAC1/CCND2/ATR/RRAS/CAPN2/VDAC2/HLA-B/NBN/SLC25A5/ZFP36L2/TRAF3IP2/RAD50/GADD45B/VDAC3/HUS1/IL1A/MDM2/MCU/PIK3R3/MAP2K1/SIRT1/E2F4/PPP3R1/MAPKAPK2/MAP2K2/RAD1/CDK4/PIK3CA/MAP2K3/MAPK1/PPP3CB/CHEK1/NFKB1/HIPK3/NRAS/CACNA1D/KRAS/HIPK1/PPP3CC/TGFBR2/BTRC/CDKN2B	4.79423969694696
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	38/1958	93/9376	1.95661581381045	MYC/LAMA2/CKS2/LAMB1/GADD45A/COL4A1/AKT1/PTEN/GADD45G/NFKBIA/COL4A5/CASP3/CDKN1B/COL4A4/CKS1B/FHIT/CYCS/ITGA6/GADD45B/COL4A3/ITGAV/PIK3R3/LAMA1/CDK4/PIK3CA/BCL2/PTK2/TRAF6/ZBTB17/COL4A2/NFKB1/COL4A6/TRAF4/MAX/TRAF2/SKP2/CDKN2B/CHUK	4.76303115675477
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	81/1958	250/9376	1.55149336057201	ATP6V0E1/LAPTM4A/OSTM1/CD164/ATP6V1G1/VPS29/CTSK/CLTA/CLN5/M6PR/OSBP/HYAL2/LAPTM4B/LAMTOR3/AP1S1/AP1G1/VPS26A/AP3S1/ARL8A/LAMP2/BLOC1S2/HEXA/CTBS/BLOC1S4/RAB7A/LAMP1/ATP6V1C2/ATP6V1C1/GLA/ARL8B/SNAPIN/MANBA/NEU1/RRAGC/SPG11/RRAGA/LAMTOR1/SGSH/TELO2/STX17/AP5M1/NAGPA/BORCS6/AP3M1/SLC11A2/GALC/ABCA5/ARSB/VAMP7/ATP6V1H/SLC36A4/BORCS5/SCARB2/RRAGB/BLOC1S6/BORCS8/AP4M1/ASAH1/AP3M2/NAGLU/NPC1/DEPTOR/VPS13A/ATP6V0E2/VPS13C/GLB1/ATP6V1D/FIG4/AP2M1/LIPA/ATP6V1A/IDS/SLC15A4/VPS11/LAMTOR5/DTNBP1/AP4S1/KXD1/AP4B1/CTNS/CTSC	4.54065628108928
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/1958	78/9376	2.02592912705272	LSM1/LSM6/LSM8/EXOSC3/MPHOSPH6/C1D/HSPD1/HSPA9/PFKM/LSM5/PABPC5/EXOSC1/TOB1/EXOSC7/BTG3/LSM2/EXOSC8/DCP1B/BTG2/CNOT8/LSM4/PNPT1/PATL1/EXOSC9/CNOT9/EXOSC5/DCPS/CNOT3/PAN2/PAN3/EXOSC6/DCP2/DDX6	4.6743201867841
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	44/1958	116/9376	1.81635025184037	SDHD/MDH1/FH/CAT/ADH5/SDHC/MCEE/HIBCH/GCSH/GLUD1/PGP/SDHB/PGAM1/DLD/DLAT/PFKM/SUCLA2/IDH3A/RPIA/PRPS2/ADPGK/TKT/ESD/ECHS1/RPE/PDHB/DLST/ALDH6A1/ME1/SUCLG2/ACO1/MDH2/TALDO1/SHMT2/PSPH/SUCLG1/ACAT1/ACOX1/GOT1/PCCA/SDHA/PGK1/ME3/FBP1	4.54515396961409
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	70/1958	214/9376	1.56635132168052	CALR/FAS/SKP1/TRIM5/GNG4/B2M/CALM2/TAP1/TBK1/AKT1/PDIA3/ELOC/TLR4/NFKBIA/TNFRSF1A/CASP3/TAP2/CGAS/GNAI3/AP1S1/HLA-F/AP1G1/ATR/GNB2/PAK3/RNF7/HLA-B/CYCS/CASP8/BID/PRKCA/MYD88/APOBEC3B/CUL4B/MAPK10/GNG5/FADD/RBX1/PIK3R3/MAP2K1/GNAI1/PPP3R1/MAP2K2/PIK3CA/BCL2/IRAK4/PTK2/TRAF6/CFL2/MAP2K3/CFL1/MAPK1/GNG12/RPS6KB1/TAPBPL/PPP3CB/CHEK1/NFKB1/MAPK8/NRAS/CUL4A/MAPK9/KRAS/WEE1/TRAF2/PPP3CC/TRADD/GNG11/BTRC/CHUK	4.30572440599625
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	55/1958	158/9376	1.66690371213199	RHEB/ATP6V1G1/AKT1/PTEN/TNFRSF1A/EIF4E/FNIP1/LAMTOR3/SLC3A2/DDIT4/ATP6V1C2/FZD2/ATP6V1C1/WNT6/PRKCA/CAB39/FZD1/RRAGC/RRAGA/STK11/SOS2/PIK3R3/MAP2K1/LAMTOR1/TELO2/MAP2K2/PRKAA1/PIK3CA/MAPK1/SEC13/RHOA/RPS6KB1/CAB39L/ATP6V1H/RRAGB/MAPKAP1/MIOS/DEPTOR/EIF4B/WNT2/TBC1D7/NRAS/SOS1/ATP6V1D/KRAS/RICTOR/ATP6V1A/LAMTOR5/GSK3B/DVL3/SKP2/WDR59/CASTOR2/FZD8/CHUK	4.34332066052498
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	39/1958	101/9376	1.84904782613093	VCAM1/F3/SERPINE1/CDC42/COL3A1/COL4A1/AKT1/COL4A5/CASP3/MMP2/CDKN1B/COL4A4/CXCL8/COL1A2/VEGFB/STAT1/PIM1/COL4A3/PRKCA/IL1A/MAPK10/PIK3R3/PRKCD/CDK4/PIK3CA/BCL2/PLCB3/MAPK1/COL4A2/NFKB1/COL4A6/MAPK8/NRAS/MAPK9/KRAS/VEGFC/STAT3/TGFBR2/SMAD4	4.40742011648325
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	51/1958	144/9376	1.69594824651004	PSMA2/PSMA5/PSMA3/GTF2B/PSMB2/AKT1/OPA1/PSMD11/PSMB3/PSMD12/TBPL1/PSMB5/VDAC1/PPIF/VDAC2/ERN1/CYCS/SLC25A5/ATP2A2/PSMC4/PSMC2/VDAC3/PRKCA/PSMA1/PSMB1/PSMD9/MAPK10/ATXN10/NRBF2/MCU/ATG101/PIK3R3/PSMC6/OMA1/PIK3R4/XBP1/GRIA3/WIPI1/PIK3CA/PSMD6/PUM2/PLCB3/ATXN2L/PIK3C3/BECN1/MAPK8/MAPK9/TRAF2/PSMB4/PSMA4/ATG2B	4.32373293077477
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	17/1958	32/9376	2.54392236976507	LDHB/MCEE/HIBCH/DLD/ACSS3/ECHDC1/LDHA/SUCLA2/ECHS1/ALDH6A1/SUCLG2/SUCLG1/ACOX1/PCCA/EHHADH/ACACB/MLYCD	4.49451259119448
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	66/1958	205/9376	1.54168265278158	MYC/VIM/CALR/FAS/GADD45A/SAP30/B2M/OAS1/TAP1/TBK1/AKT1/PDIA3/GADD45G/OAS2/NFKBIA/CASP3/CDKN1B/TAP2/PSMD11/PSMD12/NFKBIE/HLA-F/CCND2/HLA-B/CYCS/STAT1/CASP8/PSMC4/IRF7/BID/PSMC2/GADD45B/ENTPD3/MYD88/SAP30L/STAT2/CD44/MAPK10/MDM2/FADD/PIK3R3/HDAC1/PSMC6/TNFAIP3/CDK4/PIK3CA/BCL2/IRAK4/PSMD6/TRAF6/MAP2K3/TAPBPL/RELB/NFKB1/MAPK8/NEDD4/MAPK9/EIF2AK2/ISG15/TRAF2/STAT3/TRADD/SKP2/IFNAR1/HLA-DOB/CHUK	4.02867356561871
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	16/1958	30/9376	2.55389853592101	SDHD/MDH1/FH/SDHC/SDHB/DLD/DLAT/SUCLA2/IDH3A/PDHB/DLST/SUCLG2/ACO1/MDH2/SUCLG1/SDHA	4.3794438645128
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	22/1958	48/9376	2.19475655430712	HADHB/MCEE/HIBCH/HMGCS1/HIBADH/DLD/AOX1/ECHS1/ALDH6A1/BCAT1/ALDH2/ALDH3A2/ALDH9A1/ACAD8/HSD17B10/ACAT1/PCCA/ACADM/EHHADH/AUH/ACAA2/HADH	4.26338290152454
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/1958	138/9376	1.66558600168761	SDHD/NDUFA4/NDUFB3/ATP6V0E1/NDUFB5/NDUFC2/COX7A2L/ATP6V1G1/SDHC/NDUFV2/ATP5MC3/SDHB/NDUFA7/NDUFAB1/ATP5F1C/COX11/NDUFB8/UQCRFS1/NDUFA9/PPA2/NDUFA8/CYCS/NDUFS4/NDUFB6/NDUFS3/PPA1/ATP6V1C2/UQCRC2/COX6C/ATP6V1C1/UQCRH/ATP5PB/NDUFB4/COX8A/COX6A1/ATP6V1H/ATP5PO/ATP5MC1/ATP6V0E2/ATP5MG/ATP5PF/SDHA/NDUFA5/ATP6V1D/COX7B/ATP6V1A/COX15/NDUFA12	4.04672144775631
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	78/1958	253/9376	1.4763148651322	ACTG1/MYL12B/SKP1/RIPK2/UBE2N/ARF1/ARPC3/CDC42/ARPC1A/ATG5/TIFA/IL1R1/TBK1/PPID/AKT1/MYL12A/MAP1LC3B/TLR4/NFKBIA/TNFRSF1A/PFN2/UBE2D1/CGAS/CXCL8/CALCOCO2/VDAC1/UBE2V2/CAPN2/BCL10/CYCS/ACTR3/ARPC5L/MYD88/CD44/MAPK10/RRAGC/RRAGA/MDM2/PFN1/RBX1/PIK3R3/ATG16L1/ARPC5/PIK3R4/PRKCD/WIPI1/ARPC1B/PIK3CA/BCL2/PTK2/TRAF6/CTTN/PLCB3/ARF6/BCAR1/MAPK1/RHOA/MALT1/PIK3C3/RPS6KB1/ACTN1/UBC/RRAGB/BNIP3/NFKB1/BECN1/MAPK8/MAPK9/WASF1/TRAF2/WASL/GSK3B/TRADD/UBE2D4/CASP4/BTRC/CHUK/ELMO2	3.94579143758045
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	59/1958	180/9376	1.56958347520145	CALR/SRSF9/PILRA/FAS/IFNGR1/SOCS3/RHEB/B2M/OAS1/PPP1CB/TAP1/SRSF7/TBK1/SRSF1/IFNGR2/AKT1/PDIA3/OAS2/NFKBIA/TNFRSF1A/CASP3/TAP2/CGAS/HLA-F/PPP1CC/HLA-B/RNASEL/CYCS/STAT1/CASP8/IRF7/BID/EIF2S1/SRSF6/SRSF8/SRSF2/MYD88/ALYREF/STAT2/FADD/PIK3R3/EIF2B3/PIK3CA/BCL2/IRAK4/SP100/TRAF6/EIF2B1/EIF2B2/TAPBPL/NFKB1/EIF2AK2/TRAF2/TRADD/IFNAR1/HLA-DOB/PTPN11/NECTIN2/CHUK	3.96408282244942
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	73/1958	235/9376	1.48751005150718	ACTG1/SDHD/NDUFA4/NDUFB3/NDUFB5/RHEB/NDUFC2/COA6/COX7A2L/SDHC/NDUFV2/ATP5MC3/NDUFAF1/SDHB/NDUFA7/NDUFAB1/ATP5F1C/ACTL6A/COA4/SMARCE1/COX11/NDUFB8/UQCRFS1/NDUFA9/NDUFA8/ATF2/NDUFS4/NDUFB6/NDUFS3/UQCRC2/ADCY3/COX6C/UQCRH/NDUFAF4/PRKG1/SOS2/NDUFAF7/SLC25A20/KDM1A/PRKAA1/ATP5PB/NDUFB4/COX8A/COA1/MAP2K3/COX6A1/RPS6KB1/GNAS/ACSL1/COA3/COX18/ATP5PO/COA5/ATP5MC1/ZNF516/ATP5MG/COX14/ATP5PF/SDHA/FGFR1/NRAS/SOS1/NDUFA5/ACSL5/COX7B/KRAS/CREB3L4/PRKAG1/PRKAB1/SMARCB1/COX15/NPR1/NDUFA12	3.88838463672724
Human Diseases	Infectious disease: viral	hsa05162	Measles	47/1958	136/9376	1.6548699152797	FAS/HSPA1B/HSPA8/OAS1/RAB9A/HSPA1A/CD46/TBK1/AKT1/OAS2/TLR4/NFKBIA/CASP3/CDKN1B/CCND2/CYCS/RCHY1/STAT1/CASP8/MX1/IRF7/BID/EIF2S1/EIF3H/MYD88/CSNK2B/STAT2/IL1A/MAPK10/FADD/PIK3R3/TNFAIP3/CDK4/PIK3CA/BCL2/IRAK4/TRAF6/CSNK2A2/NFKB1/MAPK8/MAPK9/EIF2AK2/STAT3/GSK3B/TRADD/IFNAR1/CHUK	3.95218326997738
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	21/1958	46/9376	2.18608162721499	PSMA2/PSMA5/PSMA3/PSMB9/PSMB2/PSMD11/PSMB3/PSMD12/PSMB5/PSMB8/PSMC4/PSMC2/PSMA1/PSMB1/PSMD9/PSMC6/PSMD6/PSME2/PSMB10/PSMB4/PSMA4	4.1428693733544
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	18/1958	37/9376	2.32956961046849	UAP1/GALK2/PGM3/PGM2/UXS1/GFPT1/CMAS/TGDS/FPGT/NANP/PGM1/GALE/UGP2/UGDH/GNPNAT1/MPI/GFPT2/GMPPB	4.16303748884212
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	65/1958	205/9376	1.51832382470914	SDHD/NDUFA4/NDUFB3/NDUFB5/NDUFC2/PPP1CB/COL3A1/COX7A2L/SDHC/NDUFV2/AKT1/ATP5MC3/PTEN/MMP2/SDHB/NDUFA7/NDUFAB1/ATP5F1C/COL1A2/PPP1CC/VDAC1/PPIF/NDUFB8/UQCRFS1/VDAC2/NDUFA9/GSR/NDUFA8/SLC25A5/NDUFS4/NDUFB6/NDUFS3/ATP2A2/GFPT1/MPC2/VDAC3/UQCRC2/COX6C/PRKCA/UQCRH/MAPK10/PDHB/PIK3R3/PRKCD/ATP5PB/PIK3CA/NDUFB4/CAMK2D/MPC1/COX8A/PLCB3/COX6A1/ATP5PO/NFKB1/ATP5MC1/ATP5PF/SDHA/MAPK8/NDUFA5/MAPK9/COX7B/GSK3B/TGFBR2/GFPT2/NDUFA12	3.85494621308847
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	20/1958	44/9376	2.17661807038722	OSTC/DAD1/MGAT2/DDOST/STT3B/ALG14/ALG2/HEXA/ALG1/ALG13/MGAT4B/MAN1A1/B4GALT3/FUT8/RPN1/TUSC3/MAN1C1/STT3A/MGAT4C/B4GALT1	4.01904671845862
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	70/1958	227/9376	1.47664838255345	MYC/CALR/FAS/GNG4/RHEB/B2M/CALM2/PDGFRA/TAP1/IL1R1/TBK1/AKT1/PDIA3/NFKBIA/TNFRSF1A/CASP3/TAP2/CGAS/GNAI3/CXCL8/CTNNB1/HLA-F/GNB2/HLA-B/CYCS/ATF2/CASP8/BID/ADCY3/PRKCA/ITGAV/GNG5/MDM2/SOS2/FADD/PIK3R3/MAP2K1/GNAI1/PPP3R1/MAP2K2/CDK4/PIK3CA/PTK2/PLCB3/BCAR1/MAPK1/RHOA/GNG12/RPS6KB1/GNAS/TAPBPL/PPP3CB/NFKB1/NRAS/SOS1/ATF6B/KRAS/ELK1/TRAF2/CREB3L4/STAT3/PPP3CC/GSK3B/ARHGEF1/TRADD/GNA13/GNG11/GNA12/CHUK/ARHGEF11	3.73484691797868
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	18/1958	38/9376	2.26826514703511	UAP1/GNPDA2/GALK2/PGM3/PGM2/HEXA/UXS1/GNPDA1/GFPT1/FPGT/PGM1/GALE/UGP2/UGDH/GNPNAT1/MPI/GFPT2/GMPPB	4.02460709794081
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	63/1958	200/9376	1.50839632277835	ACTG1/FAS/ARF1/ARPC3/CLDN20/TUBA3D/CDC42/ARPC1A/IL1R1/MYO1B/SEC24D/TLR4/NFKBIA/TNFRSF1A/CASP3/CASP7/CXCL8/PAK3/TMED10/CYCS/CASP8/SEC24A/NCK1/TMBIM6/BRK1/ACTR3/ARPC5L/ABL1/MYD88/RAB1A/MAPK10/FADD/SEC24C/ARPC5/CLDN23/ARPC1B/WASF3/IRAK4/TRAF6/CTTN/ARF6/MAPK1/RHOA/NCK2/SEC24B/TUBB2A/NFKB1/FYN/MAPK8/MAPK9/WASF1/TRAF2/TUBB6/WASL/CLDN12/ARHGEF1/TRADD/GNA13/CASP4/PTPN11/GNA12/CHUK/ARHGEF11	3.73369865620485
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	69/1958	224/9376	1.47504742448563	MYC/IL15RA/CALR/ZFP36/RAN/B2M/CANX/NRP1/CHEK2/CDC26/IL1R1/RANBP1/NFYB/AKT1/PTEN/NFKBIA/TNFRSF1A/TBPL1/HLA-F/VDAC1/CCND2/ATR/VDAC2/FOSL1/HLA-B/ATF2/SLC25A5/BUB3/IL15/VDAC3/ADCY3/ANAPC13/CDC27/MAPK10/CDC23/ANAPC10/ANAPC7/PIK3R3/MAP2K1/PPP3R1/MAP2K2/CDK4/PIK3CA/MAD1L1/ANAPC4/MAPK1/PPP3CB/RELB/CHEK1/NFKB1/KAT2B/MAPK8/NRAS/MAPK9/ATF6B/KRAS/ELK1/CREB3L4/XPO1/PPP3CC/KAT2A/ESPL1/HLA-DOB/TGFBR2/SMAD4/CDKN2B/CHUK/CDC16/CRTC2	3.6970177759363
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	12/1958	21/9376	2.73631985991537	CHST7/DSEL/CSGALNACT2/CHST11/B4GALT7/DSE/B3GALT6/CHST15/CHST14/CHSY3/UST/XYLT2	4.09228669444699
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/1958	125/9376	1.64726455566905	CERS2/SPTSSA/ORMDL1/S1PR3/AKT1/PTEN/TNFRSF1A/GNAI3/DEGS1/SGMS2/SPTLC1/BID/PRKCA/MAPK10/PIK3R3/BDKRB2/MAP2K1/GNAI1/PPP2CB/NSMAF/MAP2K2/PIK3CA/BCL2/PLCB3/SGPP1/CERS5/MAPK1/RHOA/NFKB1/ASAH1/CERS6/FYN/CERS4/MAPK8/NRAS/MAPK9/KRAS/PLD1/TRAF2/ABCC1/TRADD/GNA13/GNA12	3.74275206874825
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	29/1958	75/9376	1.85157643854273	FAS/SERPINE1/GADD45A/CHEK2/RPRM/PTEN/GADD45G/CASP3/SIAH1/CCND2/ATR/CYCS/RCHY1/CASP8/BID/GADD45B/GORAB/PERP/MDM2/CCNG1/CDK4/BCL2/CCNG2/CHEK1/RRM2B/COP1/MDM4/SESN3/TP53I3	3.80397815093696
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	59/1958	187/9376	1.5108290135629	TXN/GBP1/CXCL1/ANTXR1/RIPK2/TXNIP/GBP3/OAS1/ATG5/TANK/TBK1/MAP1LC3B/OAS2/TLR4/NFKBIA/CXCL8/VDAC1/VDAC2/HSP90AB1/RNASEL/GABARAPL2/STAT1/CASP8/IRF7/VDAC3/MYD88/STAT2/NEK7/MAPK10/NAMPT/IFI16/FADD/MCU/ATG16L1/TP53BP1/MFN1/TRIP6/TNFAIP3/ANTXR2/PRKCD/BCL2/IRAK4/TRAF6/PLCB3/CARD6/PKN2/MAPK1/RHOA/NLRP1/PANX1/ERBIN/NFKB1/MAPK8/MAPK9/TRAF2/IFNAR1/SUGT1/CASP4/CHUK	3.62502328748714
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/1958	33/9376	2.32172594174637	BET1/SEC22B/VAMP3/VAMP5/STX11/STX18/STX17/GOSR1/STX6/STX7/BNIP1/GOSR2/STX5/VAMP7/VAMP4/SNAP23	3.90754310040144
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	41/1958	119/9376	1.64983991553721	CEBPB/VCAM1/FAS/CXCL1/SOCS3/JUNB/CXCL5/MAP3K8/AKT1/NFKBIA/TNFRSF1A/CASP3/CASP7/ATF2/IL15/CASP8/ADAM17/MAPK10/CSF1/FADD/MLKL/PIK3R3/MAP2K1/TNFAIP3/RHBDF1/PGAM5/PIK3CA/MAP2K3/MAPK1/CYLD/NFKB1/MAPK8/IRF1/MAPK9/ATF6B/VEGFC/TRAF2/CREB3L4/CASP10/TRADD/CHUK	3.66516305364635
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	50/1958	154/9376	1.55472719313373	AK6/CMPK1/COQ2/NQO1/NME7/PTS/DLD/NADK2/RFK/NFS1/RDH12/MOCS2/ALAD/CPOX/GGH/GSS/HSD17B6/COQ5/NME3/HMBS/BCAT1/RDH11/ALAS1/ALDH2/LIPT1/OXSM/COQ6/ALDH3A2/CMPK2/NME1/PANK3/NADK/SHMT2/PNPO/EARS2/PHOSPHO2/MAT2A/UGP2/UGDH/MTHFD2L/NMNAT1/AK3/CTPS1/MPI/GGCX/COX15/UMPS/PANK1/GMPPB/DHODH	3.56595472398399
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	19/1958	43/9376	2.11587524051595	HADHB/ADH5/ACADVL/ECHS1/ECI2/ALDH2/CYP2U1/ALDH3A2/ALDH9A1/ACSL1/ACAT1/ACOX1/ACADM/EHHADH/ACSL5/ECI1/ACAA2/GCDH/HADH	3.76779966960966
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	51/1958	158/9376	1.54567435124966	MYC/SKP1/GADD45A/CHEK2/CDC26/YWHAQ/GADD45G/CDKN1B/CCND2/ATR/PCNA/CDC7/MAD2L1BP/BUB3/CCNH/GADD45B/ANAPC13/ABL1/CDC27/TFDP1/CDC23/ANAPC10/ANAPC7/MDM2/RBX1/HDAC1/PPP2CB/HDAC8/E2F4/CDK4/CDC14B/YWHAG/ZBTB17/MAD1L1/ANAPC4/TFDP2/NDC80/CHEK1/ESCO1/WAPL/WEE1/ORC4/GSK3B/ESPL1/SKP2/SMAD4/CDKN2B/MCM3/CDC16/CDKN1C/CDC6	3.55379440927773
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	45/1958	137/9376	1.57288459100974	ACTG1/FAS/GADD45A/TUBA3D/CTSK/AKT1/EIF2AK3/GADD45G/NFKBIA/TNFRSF1A/CASP3/HTRA2/CASP7/CAPN2/ERN1/CYCS/CASP8/BID/EIF2S1/GADD45B/MAPK10/FADD/PIK3R3/DDIT3/MAP2K1/MCL1/MAP2K2/PIK3CA/BCL2/AIFM1/MAPK1/NFKB1/PARP3/MAPK8/NRAS/MAPK9/PARP2/KRAS/PARP4/TRAF2/CASP10/TRADD/CASP2/CHUK/CTSC	3.47027193948099
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	43/1958	130/9376	1.58390822660486	GNG4/COL3A1/COL4A1/AKT1/NFKBIA/COL4A5/MMP2/COL4A4/GNAI3/COL1A2/GNB2/EDNRB/VEGFB/ATF2/ADCY3/COL4A3/PRKCA/MAPK10/GNG5/SOS2/PIK3R3/MAP2K1/GNAI1/SHC3/MAP2K2/PIK3CA/PLCB3/MAPK1/COL4A2/GNG12/GNAS/NFKB1/COL4A6/MAPK8/NRAS/SOS1/MAPK9/ATF6B/KRAS/VEGFC/CREB3L4/GNG11/TGFBR2	3.44419627777784
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	60/1958	196/9376	1.46588563924037	MYC/ZFP36/FAS/CXCL1/IFNGR1/FGF2/GNG4/CALM2/TBK1/AKT1/MAP1LC3B/NFKBIA/TNFRSF1A/CASP3/CLEC2B/CXCL8/CTNNB1/HLA-F/GNB2/HLA-B/CYCS/STAT1/CASP8/IRF7/BID/STAT2/MAPK10/GNG5/HIF1A/IL6ST/FADD/PIK3R3/MAP2K1/PPP3R1/MAPKAPK2/MAP2K2/CDK4/PIK3CA/MICA/MAPK1/PIK3C3/GNG12/UBC/PPP3CB/NFKB1/ATG3/BECN1/MAPK8/NRAS/MAPK9/EIF2AK2/KRAS/TRAF2/STAT3/PPP3CC/GSK3B/TRADD/GNG11/IFNAR1/CHUK	3.38637138908241
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	65/1958	216/9376	1.44100177808043	SOD2/VCAM1/FAS/CXCL1/HSPA5/HSPA1B/HSPA8/RAP1B/CDC42/CALM2/HSPA1A/TANK/TBK1/AKT1/HSPA4/EIF2AK3/TLR4/NFKBIA/TNFRSF1A/CASP3/CASP7/CXCL8/HSPD1/CYP2A7/ERN1/CYP2B6/HSP90AB1/CYCS/CASP8/IRF7/BID/EIF2S1/PRKCA/MYD88/ERO1A/MAPK10/PIK3R3/DDIT3/XBP1/PPP3R1/PIK3CA/BCL2/IRAK4/CAMK2D/PTK2/TRAF6/PLCB3/MAP2K3/RAP1A/CYP2J2/MAPK1/RHOA/ABCA1/PPP3CB/NFKB1/MAPK8/NRAS/MAPK9/KRAS/TRAF2/STAT3/PPP3CC/GSK3B/ARHGEF1/CHUK	3.36874429218882
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	12/1958	23/9376	2.49837900253142	HMGCS1/ZMPSTE24/GGPS1/NUS1/IDI1/HMGCR/ICMT/FNTA/RCE1/ACAT1/PDSS2/PMVK	3.69622752425215
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	73/1958	250/9376	1.39825944841675	ARF4/HSPA1B/HSPA8/ARF1/ARPC3/SNX3/WASHC3/CDC42/ARPC1A/PDGFRA/CAPZA2/CHMP5/HSPA1A/SPART/VPS29/CLTA/VPS37A/STAM/SNX2/HLA-F/VPS26A/ARFGAP3/RAB10/HLA-B/STAM2/CAV2/RAB7A/SNX1/TSG101/ACTR3/RAB4A/PDCD6IP/ARPC5L/CAPZB/CHMP7/RAB22A/RUFY2/CAPZA1/ARAP1/MDM2/SPG21/ARPC5/VTA1/PSD3/WASHC5/EPS15/STAMBP/ARPC1B/TRAF6/RUFY1/ARFGEF1/EPS15L1/RAB8A/VPS25/ARF6/SNF8/RHOA/CHMP2B/ZFYVE16/VPS45/WASHC4/AMPH/NEDD4/GRK4/PLD1/AP2M1/WASL/SNX4/PSD/PIP5K1B/CHMP1B/TGFBR2/RAB11FIP2	3.27902273217041
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	23/1958	59/9376	1.8667266840948	NT5E/CMPK1/NME7/ENPP1/DUT/ENTPD3/DCTD/NME3/CDA/DTYMK/NUDT2/DCTPP1/CMPK2/NME1/HDDC2/RRM2B/CDADC1/CTPS1/DCK/UMPS/UCKL1/UCK1/DHODH	3.43098400173484
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	49/1958	156/9376	1.50409889735732	MYC/IFIT1/FAS/SOCS3/CLDN20/OAS1/TBK1/AKT1/YWHAQ/OAS2/NFKBIA/TNFRSF1A/CASP3/CTNNB1/RSAD2/RNASEL/CYCS/STAT1/CASP8/MX1/IRF7/BID/EIF2S1/STAT2/SOS2/FADD/PIK3R3/MAP2K1/PPP2CB/CLDN23/MAP2K2/CDK4/PIK3CA/YWHAG/TRAF6/EIF3E/MAPK1/NFKB1/NRAS/SOS1/EIF2AK2/KRAS/TRAF2/STAT3/CLDN12/GSK3B/TRADD/IFNAR1/CHUK	3.26182872941998
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/1958	56/9376	1.88121990369181	CXCL1/HSPA1B/HSPA8/ARF1/SEC22B/HSPA1A/TLR4/NFKBIA/CASP3/CASP7/HBS1L/CXCL8/SAR1B/HSPD1/CYCS/CASP8/CLK4/MYD88/RAB1A/EEF1A1/BNIP3/NFKB1	3.39796516707618
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	19/1958	47/9376	1.9358007519614	MDH1/FH/ADH5/LDHB/DLD/ACYP1/DLAT/LDHA/GLO1/PDHB/ME1/ALDH2/ALDH3A2/MDH2/ALDH9A1/ACYP2/ACAT1/ME3/ACACB	3.30417727312602
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	41/1958	128/9376	1.533835546476	NT5E/AK6/NTPCR/NME7/DGUOK/PAPSS1/ENPP1/PDE1A/PDE4B/PGM2/PPAT/FHIT/PAICS/GMPS/HPRT1/PRPS2/ENTPD3/ADCY3/PDE8B/ATIC/NME3/GMPR2/ITPA/NUDT5/NUDT9/NUDT2/GART/NME1/ENPP4/HDDC2/PGM1/PDE3A/ADA/PNP/RRM2B/HDDC3/AK3/PDE6D/DCK/PDE6B/NPR1	3.12418778807262
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	18/1958	44/9376	1.9589562633485	GTF2A2/GTF2B/TAF12/TBPL1/GTF2H2/TAF13/TAF9/GTF2A1/TAF7/GTF2H1/GTF2H5/CCNH/TAF10/GTF2H3/GTF2F2/GTF2E1/TAF4/TAF9B	3.27556589547172
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	20/1958	51/9376	1.87786657053015	ACTG1/SEC61B/ATP6V0E1/SEC61G/ARF1/KDELR2/ATP6V1G1/ATP6V1C2/ADCY3/ATP6V1C1/PRKCA/ERO1A/PDIA4/KDELR3/GNAS/ATP6V1H/ATP6V0E2/ATP6V1D/ATP6V1A/KDELR1	3.22951827539339
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	30/1958	87/9376	1.65122750167307	MYC/GADD45A/AKT1/GADD45G/CASP3/RALB/CTNNB1/CYCS/GADD45B/MLH1/MAPK10/SOS2/PIK3R3/MAP2K1/MAP2K2/PIK3CA/BCL2/MAPK1/RHOA/RPS6KB1/MAPK8/NRAS/SOS1/MAPK9/KRAS/MSH6/GSK3B/TGFBR2/SMAD4/RALA	3.13513643378527
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	52/1958	173/9376	1.43933588007109	ACTG1/FAS/IFNGR1/SOCS3/OAS1/NXT1/TBK1/IFNGR2/AKT1/OAS2/TLR4/NFKBIA/TNFRSF1A/CASP3/CXCL8/CALCOCO2/VDAC1/DNAJC3/RSAD2/RNASEL/CYCS/SLC25A5/STAT1/KPNA2/CASP8/MX1/IRF7/BID/EIF2S1/NUP98/PRKCA/MYD88/STAT2/NXT2/IL1A/PABPN1/FADD/PIK3R3/MAP2K1/RAE1/MAP2K2/CDK4/PIK3CA/IRAK4/MAPK1/NFKB1/EIF2AK2/XPO1/TRADD/IFNAR1/HLA-DOB/CHUK	2.9964261673652
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	83/1958	300/9376	1.32483486550902	MYC/DUSP1/FAS/FGF2/HSPA1B/HSPA8/RAP1B/GADD45A/CDC42/PDGFRA/HSPA1A/MAP3K8/IL1R1/CACNA2D1/AKT1/GADD45G/TNFRSF1A/CASP3/CACNA2D3/LAMTOR3/RRAS/VEGFB/STK3/CACNB2/ATF2/GADD45B/EFNA4/PRKCA/MYD88/MAP4K3/IL1A/MAPK10/CSF1/SOS2/EPHA2/DDIT3/MAP2K1/PPM1B/KITLG/JUND/EFNA5/PPP3R1/MAPK7/MAPKAPK2/MAP2K2/MAP3K12/DUSP5/IRAK4/TRAF6/DUSP7/MAP2K3/RAP1A/MAPK1/PPM1A/GNG12/CACNA1G/PPP3CB/PDGFRB/RELB/NFKB1/FGFR1/MAPK8/NRAS/SOS1/CACNA1D/MAPK9/ANGPT1/KRAS/ELK1/VEGFC/MAX/TRAF2/PPP3CC/MKNK2/ECSIT/FGF7/TRADD/MAPKAPK5/PLA2G4C/TGFBR2/PDGFC/GNA12/CHUK	2.93781597725311
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	14/1958	32/9376	2.0949948927477	TNFRSF1A/CASP3/HTRA2/CASP7/CYCS/CASP8/BID/MAPK10/FADD/BCL2/BECN1/MAPK8/MAPK9/BIRC6	3.18763976034435
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	29/1958	85/9376	1.63374391636123	NT5E/AK6/CMPK1/NTPCR/NME7/DGUOK/ENPP1/GMPS/DUT/HPRT1/ENTPD3/DCTD/NME3/GMPR2/ITPA/CDA/DTYMK/DCTPP1/CMPK2/NME1/HDDC2/ADA/PNP/RRM2B/AK3/CTPS1/DCK/UCKL1/UCK1	3.01536995756495
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	59/1958	203/9376	1.3917488942673	ACTG1/MYL12B/LAMA2/LAMB1/RAP1B/CDC42/PPP1CB/PDGFRA/COL4A1/AKT1/MYL12A/PTEN/COL4A5/COL4A4/COL1A2/CTNNB1/PPP1CC/CCND2/CAPN2/PAK3/VEGFB/CAV2/ITGB5/ITGA6/COL4A3/ITGA1/PRKCA/MAPK10/ITGAV/SOS2/PIK3R3/MAP2K1/LAMA1/SHC3/PIK3CA/BCL2/PTK2/RAP1A/PPP1R12B/BCAR1/COL6A1/MAPK1/RHOA/COL4A2/ACTN1/PDGFRB/THBS2/FYN/COL4A6/MAPK8/SOS1/MAPK9/ELK1/VEGFC/GSK3B/COL6A2/PIP5K1B/PDGFC/ITGB8	2.89900302791878
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	59/1958	204/9376	1.38492659576599	DCN/MYC/ACTG1/PLAU/FAS/TWIST1/FGF2/CDC42/PPP1CB/SDC4/DDX5/AKT1/LUM/TLR4/CASP3/MMP2/SDC2/COL1A2/CTNNB1/PPP1CC/RRAS/CAV2/ITGB5/FZD2/WNT6/PRKCA/PLAUR/FZD1/CD44/ITGAV/HIF1A/MDM2/SOS2/PIK3R3/MAP2K1/NUDT16L1/MAP2K2/PIK3CA/CAMK2D/PTK2/CTTN/PPP1R12B/MAPK1/RHOA/RPS6KB1/EIF4B/WNT2/FGFR1/NRAS/HPSE/SOS1/HSPB2/KRAS/ELK1/STAT3/ARHGEF1/HOXD10/PTPN11/FZD8	2.85568004646369
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	30/1958	90/9376	1.59618658495063	IFNGR1/IFNGR2/AKT1/PTEN/TLR4/NFKBIA/NFKBIE/STAT1/MYD88/CSNK2B/HIF1A/PIK3R3/MAP2K1/PPP3R1/MAP2K2/PIK3CA/TRAF6/CSNK2A2/MAP2K3/MAPK1/RPS6KB1/PPP3CB/NFKB1/NRAS/KRAS/STAT3/BATF2/PPP3CC/PTPN11/CHUK	2.91969631716901
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	21/1958	57/9376	1.76420622547175	SCP2/HADHB/ACADVL/HACD1/HSD17B4/ELOVL6/ECHS1/OXSM/ELOVL4/HACD3/CBR4/ELOVL5/ACSL1/ACAT1/ACOX1/ELOVL3/ACADM/EHHADH/ACSL5/ACAA2/HADH	2.97311638730923
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/1958	83/9376	1.61541774862473	SKP1/UBE2D1/PHC2/PCGF5/CSNK2B/USP45/TFDP1/ASXL3/HDAC1/MGA/SUZ12/PCGF2/SCML1/L3MBTL3/PCGF6/PHF1/PHC3/FOXK2/CBX8/PHF19/SCML2/RING1/FBRSL1/MAX/RNF2/UBE2D4/E2F6/AEBP2	2.8932080325484
Genetic Information Processing	Translation	hsa03010	Ribosome	63/1958	222/9376	1.35891560610662	MRPL32/RPS7/MRPL18/MRPL42/MRPL50/MRPS28/RPL22L1/RPL27/MRPL3/RPS10/MRPL17/MRPL13/MRPL44/MRPL47/MRPS22/MRPL39/RPL23A/RPS21/MRPS14/RPL7A/MRPS35/MRPS23/MRPL15/MRPL9/MRPS30/MRPL34/MRPL16/RPL32/MRPL22/FAU/MRPL36/DAP3/MRPS7/MRPL45/MRPL35/RPS13/RPS15A/MRPL14/RPL26L1/MRPS26/MRPL11/RPL30/MRPL10/MRPL53/MRPS17/MRPL19/RSL24D1/MRPS15/RPL26/MRPS2/MRPS25/MRPL46/MRPS10/MRPL43/MRPS11/MRPS18C/MRPS27/RPS25/MRPL30/MRPS33/RPL10A/RPL14/MRPS12	2.78042985446158
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1958	99/9376	1.54781729449758	CHPT1/RHEB/PDGFRA/AKT1/SLC22A4/PRKCA/SLC22A3/MAPK10/HIF1A/SOS2/PIK3R3/MAP2K1/LYPLA1/PLPP3/MAP2K2/WASF3/PIK3CA/MAPK1/RPS6KB1/PDGFRB/MAPK8/NRAS/SOS1/MAPK9/KRAS/PLD1/WASF1/PLPP1/PIP5K1B/PLA2G4C/PDGFC/CHKA	2.81512786234773
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	33/1958	103/9376	1.53419875640886	EIF4A3/PPP1CB/NXT1/PELO/RNGTT/CPSF6/DDX39B/HBS1L/ETF1/PPP1CC/PABPC5/ALYREF/MAGOHB/NXT2/PABPN1/WDR33/PPP2CB/PYM1/DAZAP1/CSTF2T/CPSF7/PAPOLA/CSTF3/GSPT1/MAGOH/FIP1L1/NCBP1/NUDT21/CSTF1/CSTF2/GSPT2/RNPS1/CPSF3	2.80065699406552
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	48/1958	163/9376	1.41012802596865	MYC/FAS/TBK1/AKT1/YWHAQ/TLR4/NFKBIA/CASP3/CXCL8/PCNA/CYCS/ATF2/STAT1/CASP8/IRF7/BID/VDAC3/PRKCA/MYD88/STAT2/MAPK10/SOS2/FADD/PIK3R3/MAP2K1/MAP2K2/PIK3CA/BCL2/IRAK4/TRAF6/MAP2K3/MAPK1/NFKB1/MAPK8/NRAS/SOS1/MAPK9/ATF6B/KRAS/ELK1/CREB3L4/STAT3/CASP10/DDX3X/IFNAR1/TGFBR2/SMAD4/CHUK	2.71369654511192
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	26/1958	77/9376	1.61691628085908	MYC/GADD45A/AKT1/GADD45G/NFKBIA/CDKN1B/GADD45B/ABL1/MDM2/SOS2/PIK3R3/HDAC1/MAP2K1/SHC3/MAP2K2/CDK4/PIK3CA/MAPK1/NFKB1/NRAS/SOS1/KRAS/TGFBR2/SMAD4/PTPN11/CHUK	2.79255694512518
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1958	31/9376	2.00810570364757	SEC61B/HSPA5/SRP9/SEC61G/SPCS3/SPCS1/SRP54/SRPRA/SRPRB/SEC11A/IMMP2L/SPCS2/IMMP1L	2.88832349747472
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/1958	63/9376	1.67219546994828	KMT5A/SETDB2/DLD/SMYD2/ECHS1/SMYD3/DLST/ALDH2/SETD7/ALDH3A2/ALDH9A1/PHYKPL/ACAT1/SUV39H2/EHMT1/TMLHE/EHHADH/CAMKMT/AADAT/GCDH/PRDM6/HADH	2.75023384337589
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/1958	63/9376	1.67219546994828	POLR2C/GTF2H2/POLR2B/POLR2M/POLR2K/PCNA/GTF2H1/GTF2H5/RAD23B/CCNH/POLR2H/ERCC4/CUL4B/GTF2H3/RBX1/RPA3/RAD23A/POLR2D/CUL4A/RPA2/POLR2J/POLD4	2.75023384337589
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/1958	28/9376	2.05223989493652	HADHB/HACD1/ELOVL6/ECHS1/MBLAC2/ELOVL4/HACD3/ACOT2/ELOVL5/ELOVL3/ACAA2/HADH	2.8647253753007
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1958	105/9376	1.50497592295345	MTX2/AMFR/TBK1/MAP1LC3B/EIF2AK3/OPA1/SIAH1/CALCOCO2/RRAS/GABARAPL2/RAB7A/EIF2S1/USP30/CSNK2B/TOMM20/MAPK10/HIF1A/MFN1/CCZ1/MUL1/PGAM5/CSNK2A2/RHOT1/UBC/USP15/BNIP3/BECN1/MAPK8/NRAS/MAPK9/KRAS/MTX3/TRAF2	2.67331784900765
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1958	32/9376	1.94535240040858	ATG5/ATG4C/GABARAPL2/ATG101/ATG16L1/PPP2CB/PIK3R4/ATG4A/WIPI1/PIK3C3/ATG3/BECN1/ATG2B	2.75201548339431
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	34/1958	112/9376	1.45366992558004	LAMA2/IFNGR1/HSPA1B/HSPA8/LAMB1/HSPA1A/IFNGR2/AKT1/TLR4/NFKBIA/TNFRSF1A/CASP3/SOCS1/GNAI3/PPIF/CYCS/STAT1/CASP8/ITGA6/MYD88/MAPK10/GNAI1/LAMA1/BCL2/IRAK4/TRAF6/MAP2K3/MAPK1/NFKB1/MAPK8/MAPK9/STAT3/HLA-DOB/CHUK	2.48140867282384
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	39/1958	133/9376	1.40416413864078	SOD2/GADD45A/CAT/AKT1/PTEN/GADD45G/CDKN1B/CCND2/HOMER3/GABARAPL2/GADD45B/MAPK10/STK11/MDM2/SOS2/PIK3R3/MAP2K1/SIRT1/SETD7/MAP2K2/PRKAA1/PIK3CA/CCNG2/MAPK1/BNIP3/MAPK8/NRAS/SOS1/MAPK9/KRAS/PRMT1/STAT3/PRKAG1/PRKAB1/SKP2/TGFBR2/SMAD4/CDKN2B/CHUK	2.41171335031771
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/1958	70/9376	1.57338391945134	RAP1B/CDC42/FH/AKT1/ELOC/CUL2/PAK3/PRCC/HIF1A/SOS2/RBX1/PIK3R3/MAP2K1/EGLN1/MAP2K2/PIK3CA/RAP1A/MAPK1/ARNT/NRAS/SOS1/KRAS/PTPN11	2.47378283849162
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	33/1958	109/9376	1.44974744871663	SOCS3/PPP1CB/SLC27A3/AKT1/PTEN/NFKBIA/TNFRSF1A/PPP1CC/PPP1R3C/MLX/GFPT1/MAPK10/PIK3R3/NR1H2/PRKCD/PRKAA1/PIK3CA/PPP1R3D/PYGL/RPS6KB1/SREBF1/NFKB1/MAPK8/MAPK9/CREB3L4/STAT3/ACACB/PRKAG1/PRKAB1/GSK3B/GFPT2/PTPN11/CRTC2	2.42639187650182
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	26/1958	82/9376	1.51832382470914	MGST1/CMPK1/GSTO1/MGST3/NME7/NAT1/CYP2A7/GMPS/DUT/HPRT1/NME3/ITPA/CDA/GSTM3/TPMT/NME1/CES1/GSTM5/RRM2B/CDADC1/GSTT2B/GSTA4/UMPS/UCKL1/GSTM2/UCK1	2.42189511465653
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	41/1958	142/9376	1.382612323584	TXN/MGST1/ACTG1/VCAM1/DUSP1/SUMO2/SUMO1/GSTO1/CALM2/SDC4/NQO1/MGST3/IL1R1/AKT1/TNFRSF1A/MMP2/SDC2/CTNNB1/CAV2/HSP90AB1/IL1A/MAPK10/ITGAV/GSTM3/PIK3R3/MAPK7/PRKAA1/PIK3CA/BCL2/PTK2/RHOA/PLAT/GSTM5/NFKB1/MAPK8/GSTT2B/MAPK9/KEAP1/GSTA4/GSTM2/CHUK	2.36024321943877
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	29/1958	94/9376	1.47732162649686	CEBPB/CXCL1/CXCL5/TBK1/SRSF1/NFKBIA/CASP3/CXCL8/FOSL1/HSP90AB1/CASP8/TRAF3IP2/MAPK10/FADD/JUND/TNFAIP3/MAPK7/TRAF6/MAPK1/NFKB1/CSF3/MAPK8/MAPK9/USP25/TRAF4/TRAF2/GSK3B/TRADD/CHUK	2.38947683202764
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/1958	34/9376	1.8309199062669	POLR2C/POLR2B/POLR2M/POLR2K/POLR1C/POLR3F/POLR2H/POLR3K/POLR3H/POLR1D/POLR2D/POLR1B/POLR2J	2.49360269090446
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	23/1958	71/9376	1.55122358255765	SOCS3/AKT1/SOCS2/SOCS1/CCND2/STAT1/MAPK10/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/PIK3CA/MAPK1/NFKB1/MAPK8/NRAS/IRF1/SOS1/MAPK9/KRAS/STAT3/GSK3B	2.39523066132318
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	14/1958	38/9376	1.76420622547175	NNMT/NT5E/NUDT12/AOX1/NADK2/ENPP1/BST1/NAMPT/SIRT1/NNT/NADK/PNP/NMNAT1/SIRT4	2.42506845395399
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/1958	31/9376	1.85363603413622	HIBCH/CSAD/CNDP2/ECHS1/ALDH6A1/ALDH2/ALDH3A2/ALDH9A1/ACOX1/EHHADH/MLYCD/AOC3	2.44575247096184
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	23/1958	72/9376	1.52967881057769	ATG5/TANK/TBK1/NFKBIA/CXCL8/CASP8/IRF7/AZI2/MAPK10/FADD/SIKE1/TRAF6/CYLD/NFKB1/DHX58/MAPK8/MAPK9/ISG15/TRAF2/CASP10/DDX3X/TRADD/CHUK	2.3178886262853
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	15/1958	42/9376	1.7101999124471	CAT/DLD/AOX1/MAOB/ECHS1/DLST/ALDH2/ALDH3A2/ALDH9A1/ACAT1/EHHADH/AADAT/GCDH/KYAT3/HADH	2.36984492869082
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/1958	42/9376	1.7101999124471	ATG5/MAP1LC3B/VDAC2/SLC39A14/SLC3A2/VDAC3/PRNP/GSS/SAT2/SLC11A2/ACSL1/NCOA4/ACSL5/LPCAT3/SAT1	2.36984492869082
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	35/1958	120/9376	1.3966632618318	RIPK2/RAP1B/CDC42/CALM2/AKT1/NFKBIA/NFKBIE/ABL1/MAPK10/SOS2/PIK3R3/MAP2K1/MAPK7/SHC3/MAPKAPK2/PRKCD/MAP2K2/PIK3CA/BCL2/IRAK4/CAMK2D/TRAF6/RAP1A/MAPK1/RHOA/NFKB1/ZNF274/MAPK8/NRAS/SOS1/MAPK9/KRAS/IRAK2/GSK3B/PTPN11	2.24672281929492
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	47/1958	170/9376	1.32389593222376	MGST1/MYC/ACTG1/GADD45A/GSTO1/NQO1/MGST3/AKT1/PTEN/GADD45G/ACTL6A/CTNNB1/SMARCE1/GADD45B/FZD2/WNT6/PRKCA/FZD1/SOS2/GSTM3/PHF10/TXNRD1/PIK3R3/MAP2K1/SHC3/MAP2K2/CDK4/PIK3CA/MAPK1/RPS6KB1/GSTM5/WNT2/NRAS/SOS1/GSTT2B/KRAS/ELK1/KEAP1/GSTA4/SMARCB1/GSK3B/PBRM1/DVL3/TGFBR2/GSTM2/SMAD4/FZD8	2.1894903561324
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	17/1958	50/9376	1.62811031664964	L3HYPDH/P4HA3/OAT/MAOB/AMD1/ODC1/CNDP2/CKMT2/ALDH2/LAP3/ALDH3A2/ALDH9A1/SAT2/ALDH18A1/GOT1/PYCR2/SAT1	2.28781967602061
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	24/1958	77/9376	1.49253810540838	GADD45A/CDC42/AKT1/GADD45G/RALB/STAT1/GADD45B/MAPK10/PIK3R3/MAP2K1/CDK4/PIK3CA/MAPK1/RPS6KB1/NFKB1/MAPK8/MAPK9/KRAS/PLD1/STAT3/TGFBR2/SMAD4/RALA/CHUK	2.22954191625745
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	39/1958	138/9376	1.35328862637119	SOCS3/RHEB/CALM2/PPP1CB/PHKG1/AKT1/SOCS2/RHOQ/SOCS1/EIF4E/PPP1CC/PPP1R3C/MAPK10/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/PRKAA1/PIK3CA/PPP1R3D/MAPK1/PYGL/RPS6KB1/PRKAR1A/PPP1R3F/SREBF1/MAPK8/NRAS/SOS1/MAPK9/KRAS/ELK1/ACACB/PRKAG1/MKNK2/PRKAB1/GSK3B/FBP1	2.1479728509309
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	22/1958	70/9376	1.50497592295345	SOCS3/AKT1/NFKBIA/TNFRSF1A/NFKBIE/ADIPOR1/MAPK10/STK11/PRKAA1/ACSL1/NFKB1/MAPK8/MAPK9/ACSL5/TRAF2/STAT3/ACACB/PRKAG1/PRKAB1/TRADD/PTPN11/CHUK	2.17864633045353
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1958	98/9376	1.41702278459903	ARPC3/MARCKSL1/CDC42/ARPC1A/GSN/AKT1/ACTR3/ARPC5L/PRKCA/MARCKS/PIK3R3/MAP2K1/ARPC5/PLPP3/PRKCD/ARPC1B/WASF3/PIK3CA/CFL2/ARF6/CFL1/MAPK1/RPS6KB1/AMPH/PLD1/WASF1/PLPP1/PIP5K1B/PLA2G4C	2.13203438723242
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	26/1958	86/9376	1.44770411193197	MYC/AKT1/CDKN1B/PAK3/NCK1/PRKCA/ABL1/MAPK10/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/PIK3CA/CAMK2D/PTK2/MAPK1/RPS6KB1/NCK2/MAPK8/NRAS/SOS1/MAPK9/KRAS/ELK1/GSK3B	2.14279694850597
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	18/1958	55/9376	1.5671650106788	CERS2/HEXA/DEGS1/SGMS2/SPTLC1/GLA/NEU1/PLPP3/SGPP1/CERS5/GALC/ACER3/ASAH1/KDSR/CERS6/CERS4/GLB1/PLPP1	2.16724539522712
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/1958	59/9376	1.54207856512179	MGST1/GSTO1/GGT5/MGST3/PRDX6/ODC1/GSR/GPX8/GSS/GSTM3/GSTK1/LANCL1/LAP3/TXNDC12/GSTM5/RRM2B/GSTT2B/GSTA4/GSTM2	2.14584703430317
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	19/1958	59/9376	1.54207856512179	MYC/GADD45A/AKT1/PTEN/GADD45G/CTNNB1/GADD45B/MLH1/SOS2/PIK3R3/MAP2K1/MAP2K2/PIK3CA/MAPK1/NRAS/SOS1/KRAS/ELK1/GSK3B	2.14584703430317
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	30/1958	103/9376	1.39472614218987	CALR/FAS/IFNGR1/SERPINE1/IFNGR2/AKT1/TLR4/NFKBIA/TNFRSF1A/GNAI3/CXCL8/CASP8/MYD88/MAPK10/FADD/PIK3R3/BDKRB2/GNAI1/PPP2CB/PIK3CA/IRAK4/TRAF6/PLCB3/MAPK1/GNAS/NFKB1/MAPK8/MAPK9/TGFBR2/CHUK	2.06944047997457
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1958	71/9376	1.48377907896819	CXCL1/ATP6V0E1/CDC42/ATP6V1G1/NFKBIA/CASP3/CXCL8/ADAM17/ATP6V1C2/ATP6V1C1/MAPK10/JAM3/ATP6V1H/NFKB1/ATP6V0E2/MAPK8/ATP6V1D/MAPK9/ATP6V1A/ADAM10/PTPN11/CHUK	2.10216420327064
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1958	75/9376	1.46849165815458	MGST1/FAS/GSTO1/MGST3/AKT1/CASP3/CYCS/CASP8/BID/MLH1/MDM2/GSTM3/FADD/PIK3R3/TOP2B/PIK3CA/BCL2/MAPK1/GSTM5/GSTT2B/GSTA4/MSH6/GSTM2	2.09274464493867
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/1958	19/9376	2.01623568625343	HYAL2/HEXA/SGSH/ARSB/NAGLU/GLB1/HPSE/IDS	2.27798832931937
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	84/1958	333/9376	1.20792498320588	FAS/LAMA2/ATP6V0E1/LAMB1/CDC42/RHEB/ATP6V1G1/TBK1/COL4A1/AKT1/PTEN/TNFRSF1A/COL4A5/CASP3/CDKN1B/COL4A4/TBPL1/COL1A2/CTNNB1/HLA-F/CCND2/ATR/HLA-B/STAT1/ITGB5/CASP8/MX1/ITGA6/ATP6V1C2/FZD2/ATP6V1C1/WNT6/COL4A3/ITGA1/STAT2/FZD1/ITGAV/TADA3/MDM2/SOS2/FADD/PIK3R3/HDAC1/MAP2K1/PPP2CB/OASL/LAMA1/MAML2/MAP2K2/CDK4/PIK3CA/PTK2/RFNG/HES4/COL6A1/MAPK1/COL4A2/RPS6KB1/GNAS/ATP6V1H/PDGFRB/NFKB1/WNT2/ATP6V0E2/THBS2/COL4A6/NRAS/IRF1/SOS1/ATP6V1D/EIF2AK2/KRAS/ISG15/CREB3L4/ATP6V1A/GSK3B/COL6A2/TRADD/DVL3/IFNAR1/FZD8/ITGB8/CHUK/LLGL1	1.98481984644555
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	48/1958	178/9376	1.29129701254433	MYC/DKK1/CACYBP/SKP1/BAMBI/SFRP4/RYK/SFRP2/PRICKLE2/SIAH1/CTNNB1/CCND2/LZTS2/FOSL1/SERPINF1/FZD2/CBY1/WNT6/PRKCA/CSNK2B/FZD1/INVS/MAPK10/RSPO3/RBX1/SIRT1/PPP3R1/CAMK2D/CSNK2A2/PLCB3/RHOA/PPP3CB/ROR1/WNT2/TLE4/MAPK8/VANGL1/MAPK9/CCAR2/PPP3CC/GSK3B/APCDD1/DVL3/TBL1XR1/PPARD/SMAD4/BTRC/FZD8	2.01580211544208
Human Diseases	Cancer: specific types	hsa05214	Glioma	23/1958	76/9376	1.44916939949465	GADD45A/CALM2/PDGFRA/AKT1/PTEN/GADD45G/GADD45B/PRKCA/MDM2/SOS2/PIK3R3/MAP2K1/CAMK1/SHC3/MAP2K2/CDK4/PIK3CA/CAMK2D/MAPK1/PDGFRB/NRAS/SOS1/KRAS	2.01987293878835
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	38/1958	138/9376	1.31858891800269	ACTG1/ARPC3/CDC42/ARPC1A/TBK1/AKT1/TLR4/NFKBIA/CXCL8/ACTR3/ARPC5L/MYD88/MAPK10/PIK3R3/MAP2K1/ARPC5/MAP2K2/ARPC1B/PIK3CA/IRAK4/PTK2/TRAF6/MAP2K3/ARF6/PKN2/BCAR1/MAPK1/RHOA/NFKB1/MAPK8/MAPK9/TRAF2/WASL/GSK3B/ARHGEF1/PIP5K1B/CHUK/ELMO2	1.93700078461697
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	30/1958	105/9376	1.36815992995768	CALM2/AKT1/NFKBIA/RRAS/BCL10/STAT1/CASP8/STAT2/MAPK10/MDM2/PIK3R3/PPP3R1/MAPKAPK2/PRKCD/PIK3CA/MAPK1/RHOA/MALT1/CYLD/PPP3CB/RELB/NFKB1/MAPK8/NRAS/IRF1/MAPK9/KRAS/PPP3CC/PTPN11/CHUK	1.94902067070632
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	60/1958	232/9376	1.2384206262548	TMSB4X/ACTG1/MYL12B/FGF2/ARPC3/CDC42/ARPC1A/PPP1CB/PDGFRA/GSN/AKT1/MYL12A/PFN2/PPP1CC/RRAS/BDKRB1/PAK3/RGCC/ITGB5/BRK1/ITGAE/ITGA6/ACTR3/ARPC5L/ITGA1/ITGAV/PFN1/SOS2/PIK3R3/BDKRB2/MAP2K1/ARPC5/MAP2K2/ARPC1B/PIK3CA/PTK2/CFL2/ENAH/CFL1/PPP1R12B/BCAR1/MAPK1/RHOA/GNG12/ACTN1/PDGFRB/FGFR1/NRAS/SOS1/KRAS/WASF1/WASL/FGF7/ARHGEF1/GNA13/PIP5K1B/ABI2/PDGFC/GNA12/ITGB8	1.88915797330045
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1958	93/9376	1.39022702560216	ACTG1/MYL12B/SNAI2/RAP1B/CDC42/MYL12A/CTNNB1/SNAI1/CSNK2B/PTPRM/WASF3/FER/CSNK2A2/RAP1A/ACP1/YES1/MAPK1/RHOA/ACTN1/FGFR1/FYN/WASF1/WASL/TGFBR2/SMAD4/NECTIN2/NECTIN3	1.94295709345144
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	34/1958	122/9376	1.33451665299151	SOCS3/JUNB/AKT1/SOCS2/SOCS1/GNAI3/ATF2/STAT1/ADCY3/PRKCA/MAPK10/SOS2/PIK3R3/MAP2K1/GNAI1/SHC3/MAP2K2/PIK3CA/PTK2/PLCB3/MAP2K3/BCAR1/MAPK1/GNAS/MAPK8/NRAS/SOS1/CACNA1D/MAPK9/ATF6B/KRAS/CREB3L4/STAT3/GSK3B	1.91065149288102
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/1958	27/9376	1.77354064994514	SCP2/HACD1/HSD17B4/ELOVL6/ELOVL4/HACD3/ACOT2/ELOVL5/ACOX1/ELOVL3	2.06790703485662
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	8/1958	20/9376	1.91542390194076	UAP1/CMAS/TGDS/NANP/CYB5R1/UGP2/UGDH/GMPPB	2.10542951339071
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/1958	110/9376	1.34950320364008	IFNGR1/SERPINE1/LDHB/IFNGR2/AKT1/ELOC/TLR4/CUL2/EIF4E/CDKN1B/PFKM/LDHA/PRKCA/PDHB/HIF1A/RBX1/PIK3R3/MAP2K1/EGLN1/MAP2K2/PIK3CA/BCL2/CAMK2D/MAPK1/RPS6KB1/ARNT/NFKB1/PGK1/ANGPT1/STAT3/MKNK2	1.89430507615769
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/1958	31/9376	1.69916636462486	DERA/PFKM/PGM2/RPIA/PRPS2/TKT/RPE/TALDO1/PGM1/RBKS/FBP1	2.00318144444896
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1958	31/9376	1.69916636462486	MDH1/CAT/MCEE/GCSH/PGP/DLD/ACO1/MDH2/SHMT2/ACAT1/PCCA	2.00318144444896
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	39/1958	144/9376	1.29690160027239	FAS/CXCL1/ADH5/TBK1/AKT1/ACADVL/TLR4/NFKBIA/TNFRSF1A/CASP3/CXCL8/CTNNB1/TRA2A/CASP8/ADIPOR1/MYD88/MAPK10/FADD/SIRT1/ALDH2/PRKAA1/ALDH3A2/IRAK4/ALDH9A1/TRAF6/MAP2K3/SREBF1/NFKB1/ACOX1/ACADM/MAPK8/MAPK9/ACACB/PRKAG1/PRKAB1/GSK3B/TRADD/MLYCD/CHUK	1.8445670820135
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	17/1958	54/9376	1.50750955245337	FANCF/FANCL/ATR/ERCC4/MLH1/WDR48/UBE2T/TELO2/PMS2/RPA3/REV1/RAD51C/FANCM/POLI/RPA2/RMI1/MUS81	1.92147668477129
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1958	62/9376	1.46746186035784	SOD2/HSPA1B/HSPA8/CAT/ATG5/HSPA1A/AKT1/ADCY3/PIK3R3/HDAC1/SIRT1/PRKAA1/PIK3CA/RPS6KB1/NRAS/KRAS/PRKAG1/PRKAB1/SOD1	1.89724090021432
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	21/1958	71/9376	1.41633457537873	MYC/PDGFRA/LDHB/GLS/AKT1/PTEN/PGAM1/PFKM/LDHA/PDHB/HIF1A/PIK3R3/MAP2K1/MAP2K2/TIGAR/PIK3CA/MAPK1/PDGFRB/FGFR1/NRAS/KRAS	1.8090977452181
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/1958	21/9376	1.82421323994358	ENPP1/CSAD/AASDHPPT/BCAT1/ALDH2/ALDH3A2/PANK3/PANK1	1.94256654725619
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	23/1958	80/9376	1.37671092951992	FGF2/PDGFRA/AKT1/PTEN/EIF4E/PRKCA/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/PIK3CA/BCL2/MAPK1/RPS6KB1/PDGFRB/NRAS/SOS1/KRAS/STAT3/GSK3B/GAS6/PDGFC	1.73841605406376
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	33/1958	122/9376	1.29526616319764	CDC42/MAP3K8/AKT1/NFKBIA/NFKBIE/PAK3/BCL10/NCK1/MAPK10/SOS2/PIK3R3/MAP2K1/PPP2CB/PPP3R1/MAP2K2/CDK4/PIK3CA/MAPK1/RHOA/MALT1/NCK2/PPP3CB/NFKB1/FYN/MAPK8/NRAS/SOS1/MAPK9/KRAS/PPP3CC/GSK3B/PTPN11/CHUK	1.68646532382094
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/1958	18/9376	1.8622176824424	PRDX1/LMBRD1/ZNF143/MMADHC/MMAA/THAP11/MTRR	1.881092815518
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1958	29/9376	1.65122750167307	YAP1/FRMD6/MOB1A/FAT4/STK3/TEAD3/SAV1/WTIP/AJUBA/TEAD2	1.80444719632856
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	41/1958	157/9376	1.25051560477024	CEBPB/CALR/CASP3/CASP7/CD47/UQCRFS1/ODC1/GULP1/ITGB5/ATP2A2/ADAM17/RAB7A/ITGAV/HIF1A/NR1H2/MAP2K1/SIRT1/TMEM30A/XKR6/MEGF10/MAPKAPK2/MAP2K2/ADAM9/DUSP5/CAMK2D/PTK2/DUSP7/PBX1/BCAR1/MAPK1/ABCA1/ARNT/PANX1/ANO4/LIPA/VPS11/ADAM10/ATP11B/PPARD/GAS6/PTPN11	1.62626482897063
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	52/1958	205/9376	1.21465905976731	CDC42/GTF2A2/GTF2B/GSN/RANBP1/YWHAQ/NFKBIA/CASP3/CDKN1B/TBPL1/GTF2H2/HLA-F/CCND2/GTF2A1/HLA-B/GTF2H1/ATF2/CASP8/IRF7/VDAC3/MDM2/IL6ST/GTF2H3/PIK3R3/HDAC1/HDAC8/MAPKAPK2/CDK4/PIK3CA/SP100/YWHAG/MAD1L1/GTF2E1/MAPK1/RHOA/ACTN1/CHEK1/NFKB1/KAT2B/NRAS/EIF2AK2/ATF6B/KRAS/TRAF2/CREB3L4/STAT3/DDX3X/TRADD/KAT2A/SKP2/DNAJA3/CDKN2B	1.59649063019528
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/1958	37/9376	1.55304640697899	MYC/GADD45A/TFG/GADD45G/CTNNB1/GADD45B/MAP2K1/MAP2K2/MAPK1/NCOA4/NRAS/KRAS	1.7316527898917
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	25/1958	90/9376	1.33015548745886	SOD2/RHEB/CAT/ATG5/AKT1/EIF4E/ATF2/ADIPOR1/ADCY3/STK11/ATG101/PIK3R3/SIRT1/PRKAA1/PIK3CA/RPS6KB1/NFKB1/EHMT1/SESN3/NRAS/ATF6B/KRAS/CREB3L4/PRKAG1/PRKAB1	1.61686590265461
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	10/1958	30/9376	1.59618658495063	PIGF/PIGP/PIGK/PIGH/PIGV/PIGL/PIGG/PIGN/PGAP2/PIGO	1.68026780462814
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1958	12/9376	1.99523323118829	COQ2/NQO1/COQ5/COQ6/GGCX	1.77228416343959
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1958	93/9376	1.28724724592793	CDC42/CALM2/MMP2/ADCY3/PRKCA/MAPK10/SOS2/MAP2K1/MAPK7/PRKCD/MAP2K2/CAMK2D/PLCB3/MAP2K3/MAPK1/GNAS/MAPK8/NRAS/SOS1/CACNA1D/MAPK9/KRAS/ELK1/PLD1/PLA2G4C	1.43021635466902
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	28/1958	106/9376	1.26490257675333	PLAU/PDGFRA/AKT1/AR/PTEN/NFKBIA/CDKN1B/CTNNB1/HSP90AB1/MDM2/SOS2/PIK3R3/MAP2K1/MAP2K2/PIK3CA/BCL2/MAPK1/PLAT/PDGFRB/NFKB1/FGFR1/NRAS/SOS1/KRAS/CREB3L4/GSK3B/PDGFC/CHUK	1.40911947039299
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1958	68/9376	1.33797993150273	MYC/AKT1/PIM1/SOS2/PIK3R3/RARA/MAP2K1/MAP2K2/PIK3CA/MAPK1/RPS6KB1/NFKB1/NRAS/SOS1/KRAS/RUNX1T1/STAT3/PPARD/CHUK	1.43702971991847
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	20/1958	73/9376	1.31193417941148	RAN/TRIM5/CPSF6/FEZ1/NUP153/PPIA/MX1/TSG101/PDCD6IP/CDK9/APOBEC3B/CPSF7/KAT2B/NELFCD/XPO1/MLLT3/MDFIC/SMARCB1/CCNT2/KAT2A	1.37455287686813
Human Diseases	Cancer: specific types	hsa05218	Melanoma	20/1958	73/9376	1.31193417941148	FGF2/GADD45A/PDGFRA/AKT1/PTEN/GADD45G/GADD45B/MDM2/PIK3R3/MAP2K1/MAP2K2/CDK4/PIK3CA/MAPK1/PDGFRB/FGFR1/NRAS/KRAS/FGF7/PDGFC	1.37455287686813
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1958	142/9376	1.21400106461034	IFNGR1/SOCS3/JUNB/IL1R1/CTSK/IFNGR2/AKT1/NFKBIA/TNFRSF1A/SOCS1/FOSL1/STAT1/ATP2A2/STAT2/IL1A/MAPK10/CSF1/PIK3R3/MAP2K1/JUND/PPP3R1/PIK3CA/TRAF6/MAPK1/CYLD/PPP3CB/RELB/NFKB1/FYN/MAPK8/MAPK9/TRAF2/PPP3CC/IFNAR1/TGFBR2/CHUK	1.32012099601999
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	27/1958	103/9376	1.25525352797088	LAMA2/CXCL1/LAMB1/COL3A1/IL1R1/COL4A1/PRDX1/TLR4/COL4A5/CASP3/COL4A4/CXCL8/COL1A2/RAB7A/COL4A3/PRKCA/PIK3R3/LAMA1/PIK3CA/PTK2/PLCB3/COL4A2/CD1D/GNAS/ACTN1/NFKB1/COL4A6	1.33822396588361
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1958	13/9376	1.84175375186611	RAD50/LIG4/XRCC4/DCLRE1C/FEN1	1.56026293864456
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/1958	78/9376	1.28922762630628	ACTG1/ARPC3/CDC42/ARPC1A/CLTA/CTNNB1/CAV2/ACTR3/ARPC5L/PIK3R3/ARPC5/SHC3/ARPC1B/PIK3CA/PTK2/CTTN/BCAR1/RHOA/WASF1/WASL/ELMO2	1.31777380773166
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1958	78/9376	1.28922762630628	CALM2/CXCL5/TLR4/CASP3/CASP7/GNAI3/CXCL8/MYD88/IL1A/MAPK10/GNAI1/IRAK4/TRAF6/CFL2/CFL1/MAPK1/RHOA/NFKB1/MAPK8/IRF1/MAPK9	1.31777380773166
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	30/1958	117/9376	1.22783583457741	ACTG1/MORF4L2/MBD2/ACTL6A/SMARCE1/ACTR6/MEAF6/MRGBP/CDK2AP1/BCL7B/DPF2/INO80C/PHF6/PHF10/HDAC1/MCRS1/UCHL5/BCL7C/MTA2/EPC2/VPS72/BICRAL/MTA3/CHRAC1/SMARCB1/CDK2AP2/PBRM1/SS18L1/BICRA/MORF4L1	1.27403537923176
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1958	17/9376	1.69007991347714	PAPSS1/SEPHS2/SEPHS1/TXNRD1/MARS2/KYAT3	1.46304502215899
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/1958	49/9376	1.36815992995768	C1GALT1C1/POGLUT1/C1GALT1/POFUT2/C1GALT1C1L/B4GALT3/POFUT1/GXYLT1/GALNT7/RFNG/GALNT13/B4GALT1/FUT10/GALNT18	1.32743155659847
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1958	70/9376	1.2997519334598	ACTG1/LAMA2/CASP3/EIF4G2/HLA-F/SGCB/HLA-B/SNTB1/CYCS/CASP8/BID/CD55/ABL1/LAMA1/SGCE/FYN/SSPN/SNTB2/HLA-DOB	1.29323680633926
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	45/1958	184/9376	1.1711151574366	MYL12B/TRPC4/CDC42/RYK/NRP1/BOC/UNC5C/MYL12A/GNAI3/RRAS/PAK3/ABLIM3/NCK1/EFNA4/PRKCA/ABL1/ROBO1/EPHA2/TRPC1/PIK3R3/GNAI1/UNC5B/EFNA5/PPP3R1/PIK3CA/CAMK2D/PTK2/CFL2/ENAH/CFL1/MAPK1/RHOA/NCK2/PPP3CB/SEMA4B/SEMA4C/FYN/NRAS/KRAS/ABLIM2/PPP3CC/NEO1/GSK3B/PTPN11/SEMA3C	1.20431737559975
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	27/1958	105/9376	1.23134393696191	VCAM1/PLAU/CXCL1/GADD45A/IL1R1/GADD45G/TLR4/NFKBIA/TNFRSF1A/CXCL8/BCL10/GADD45B/MYD88/CSNK2B/UBE2I/TNFAIP3/BCL2/IRAK4/TRAF6/CSNK2A2/MALT1/CYLD/RELB/NFKB1/TRAF2/TRADD/CHUK	1.22472349240499
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	37/1958	149/9376	1.18910544248	AVPR1A/ARF1/RHEB/PDGFRA/AKT1/RALB/CXCL8/RRAS/ADCY3/PRKCA/SOS2/PIK3R3/MAP2K1/KITLG/PLPP3/SHC3/MAP2K2/PIK3CA/PLCB3/ARF6/MAPK1/RHOA/GNAS/PDGFRB/FYN/NRAS/SOS1/KRAS/PLD1/PLPP1/GNA13/PIP5K1B/PLA2G4C/PDGFC/PTPN11/GNA12/RALA	1.19540610485855
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/1958	54/9376	1.33015548745886	MDH1/LDHB/APIP/AMD1/LDHA/CDO1/ENOPH1/GSS/BCAT1/MTAP/MDH2/MAT2A/ADI1/GOT1/KYAT3	1.24999828758845
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	28/1958	110/9376	1.21890611941684	DCN/MYC/FST/SKP1/BAMBI/ID2/ID4/FMOD/TGIF1/BMP2/ID3/TFDP1/RBX1/HDAC1/PPP2CB/E2F4/LEMD3/MAPK1/RHOA/RPS6KB1/ZFYVE16/NBL1/CHRD/SKIL/NEO1/TGFBR2/SMAD4/CDKN2B	1.18646973445298
NA	NA	hsa04518	Integrin signaling	38/1958	154/9376	1.18159266678164	ACTG1/VCAM1/LAMA2/LAMB1/CDC42/PDGFRA/COL4A1/AKT1/COL4A5/COL4A4/COL1A2/CTNNB1/CCND2/FGB/VEGFB/ITGB5/ITGAE/ITGA6/COL4A3/ITGA1/ITGAV/PIK3R3/LAMA1/PIK3CA/PTK2/COL6A1/COL4A2/ACTN1/NCK2/PDGFRB/THBS2/COL4A6/FREM1/VEGFC/GSK3B/COL6A2/PDGFC/ITGB8	1.16733276458418
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/1958	67/9376	1.28647874010946	MINPP1/ADH5/LDHB/PGAM1/DLD/DLAT/PFKM/PGM2/LDHA/ADPGK/PDHB/ALDH2/ALDH3A2/ALDH9A1/PGM1/BPGM/PGK1/FBP1	1.20900153339021
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	44/1958	181/9376	1.16406977466013	CEBPB/IFNGR1/RIPK2/CALM2/NFYB/IFNGR2/AKT1/TLR4/TNFRSF1A/CASP3/HSPD1/HSPA9/LAMP2/BCL10/CYCS/STAT1/CASP8/BID/RAB7A/LAMP1/MYD88/IL1A/MAPK10/FADD/PPP3R1/BCL2/IRAK4/CAMK2D/TRAF6/MAPK1/RHOA/MALT1/PIK3C3/ATP6V1H/PPP3CB/CYP27B1/NFKB1/MAPK8/MAPK9/IRAK2/PPP3CC/CASP10/TRADD/HLA-DOB	1.14509249872941
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1958	14/9376	1.7101999124471	CHST2/B4GALT3/FUT8/CHST1/B4GALT1	1.36618301379864
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/1958	168/9376	1.16863660683885	FAS/IFNGR1/CHMP5/PPID/IFNGR2/TLR4/GLUD1/TNFRSF1A/VDAC1/CAPN2/VDAC2/HSP90AB1/PPIA/SLC25A5/STAT1/CASP8/BID/VDAC3/CHMP7/STAT2/IL1A/MAPK10/FADD/MLKL/TNFAIP3/PGAM5/BCL2/CAMK2D/AIFM1/CHMP2B/PYGL/CYLD/MAPK8/MAPK9/EIF2AK2/TRAF2/STAT3/TRADD/CHMP1B/PLA2G4C/IFNAR1	1.13311087607543
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	23/1958	89/9376	1.23749297035498	TUBA3D/PDGFRA/GNAI3/HTR2B/ADCY3/PRKCA/PRKG1/SOS2/MAP2K1/GNAI1/MAPK7/MAP2K2/PLCB3/MAPK1/GNAS/TUBB2A/PDGFRB/NRAS/SOS1/KRAS/GJA1/TUBB6/PDGFC	1.15652921330182
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1958	18/9376	1.59618658495063	OXSM/CBR4/ACSL1/ACSL5/ACACB/OLAH	1.30069508489088
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1958	30/9376	1.43656792645557	GGH/ATIC/ABCC3/GART/SHMT2/NFKB1/ABCC5/ABCC1/CHUK	1.2304051279807
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1958	22/9376	1.52363264927106	MAOB/HNMT/CARNMT1/CNDP2/ALDH2/ALDH3A2/ALDH9A1	1.2632460318404
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	27/1958	107/9376	1.20832816243926	CALM2/LDHB/PHKG1/PPP4C/AKT1/PGAM1/PFKM/LDHA/ATF2/PDHB/SIRT1/PPP3R1/PRKAA1/CAMK2D/PLCB3/PYGL/GNAS/PPP3CB/PPP4R3B/PRMT1/CREB3L4/ACACB/PPP3CC/PRKAG1/PRKAB1/FBP1/CRTC2	1.11345327852479
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	41/1958	170/9376	1.15488794087604	ACTG1/MYL12B/ARPC3/CLDN20/TUBA3D/CDC42/ARPC1A/YBX3/HSPA4/MYL12A/RAP2C/PCNA/ACTR3/ARPC5L/RAB13/MAPK10/RAB8B/STK11/JAM3/PPP2CB/ARPC5/CLDN23/ARPC1B/MPDZ/PRKAA1/CDK4/RAB8A/CTTN/RAP1A/RHOA/CD1D/ACTN1/MAPK8/NEDD4/CACNA1D/MAPK9/AMOTL2/PRKAG1/PRKAB1/CLDN12/LLGL1	1.04702041331913
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1958	60/9376	1.2769492679605	CDC42/AKT1/PRKCA/PIK3R3/MAP2K1/PPP3R1/MAPKAPK2/MAP2K2/PIK3CA/PTK2/MAPK1/PPP3CB/NRAS/KRAS/PPP3CC/PLA2G4C	1.10562964351456
Organismal Systems	Nervous system	hsa04730	Long-term depression	16/1958	60/9376	1.2769492679605	GNAI3/PRKCA/PRKG1/MAP2K1/GNAI1/PPP2CB/GRIA3/MAP2K2/PLCB3/MAPK1/GNAS/NRAS/KRAS/GNA13/PLA2G4C/GNA12	1.10562964351456
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1958	86/9376	1.22498040240397	ACTG1/LAMA2/CACNA2D1/CACNA2D3/CTNNB1/SGCB/SNTB1/CACNB2/ITGB5/ATP2A2/ITGA6/ITGA1/SLC8A1/ITGAV/LAMA1/SGCE/CACNA1D/SSPN/GJA1/PKP2/SNTB2/ITGB8	1.07679895470367
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	34/1958	139/9376	1.17130238607888	HSPA1B/HSPA8/CALM2/KRT23/HSPA1A/AKT1/KRT10/MMP2/GNAI3/HSP90AB1/ATF2/FKBP4/ADCY3/SOS2/PIK3R3/RARA/MAP2K1/GNAI1/PGR/SHC3/PRKCD/MAP2K2/PIK3CA/BCL2/PLCB3/MAPK1/GNAS/NRAS/SOS1/ATF6B/KRAS/CREB3L4/NCOA1/KRT34	1.04533118818617
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/1958	149/9376	1.15696745754811	NDUFA4/NDUFB3/NDUFB5/GNG4/NDUFC2/NDUFV2/NDUFA7/NDUFAB1/GNAI3/GNB2/NDUFB8/NDUFA9/NDUFA8/NDUFS4/NDUFB6/NDUFS3/NAPEPLD/ADCY3/PRKCA/ABHD6/MAPK10/GNG5/GNAI1/GABRE/GRIA3/GABRA2/NDUFB4/PLCB3/MAPK1/GNG12/MAPK8/NDUFA5/CACNA1D/MAPK9/GNG11/NDUFA12	0.992249903315073
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	27/1958	109/9376	1.18615700349542	MAP3K8/TBK1/CTSK/AKT1/TLR4/NFKBIA/CXCL8/STAT1/CASP8/IRF7/MYD88/STAT2/MAPK10/FADD/PIK3R3/MAP2K1/MAP2K2/PIK3CA/IRAK4/TRAF6/MAP2K3/MAPK1/NFKB1/MAPK8/MAPK9/IFNAR1/CHUK	1.00431885122223
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1958	23/9376	1.45738775147666	PCNA/MLH1/PMS2/RPA3/MSH6/RPA2/POLD4	1.12829210327138
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1958	19/9376	1.51217676469007	GCSH/DLD/DLAT/PDHB/DLST/LIPT1	1.14809262092925
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1958	89/9376	1.18368892816564	LAMA2/LAMB1/SDC4/COL4A1/COL4A5/COL4A4/COL1A2/CD47/ITGB5/ITGA6/COL4A3/ITGA1/CD44/ITGAV/LAMA1/COL6A1/COL4A2/THBS2/COL4A6/FREM1/COL6A2/ITGB8	0.894517472521894
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1958	24/9376	1.3966632618318	B4GALT7/B3GALT6/EXTL2/NDST2/HS2ST1/HS6ST1/XYLT2	0.999594638520141
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1958	33/9376	1.30597084223233	DLD/DLAT/IDH3A/PDHB/DLST/BCAT1/ACO1/GOT1/AADAT	0.904570467845441
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	17/1958	69/9376	1.17979008452873	AKT1/PRKCA/MAPK10/SOS2/PIK3R3/MAP2K1/MAP2K2/PIK3CA/MAP2K3/MAPK1/FYN/MAPK8/NRAS/SOS1/MAPK9/KRAS/PLA2G4C	0.770076716294535
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1958	69/9376	1.17979008452873	CALM2/PPP1CB/MAOB/PPP1CC/ATF2/PRKCA/HDAC1/SIRT1/GRIA3/PPP3R1/CAMK2D/GNAS/PPP3CB/CACNA1D/ATF6B/CREB3L4/PPP3CC	0.770076716294535
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/1958	155/9376	1.11218162048173	ACTG1/SEC61B/CALR/ATP6V0E1/SEC61G/TUBA3D/SEC22B/CANX/ATP6V1G1/TAP1/M6PR/TLR4/TAP2/HLA-F/VAMP3/STX12/LAMP2/HLA-B/COLEC11/ITGB5/RAB7A/LAMP1/ATP6V1C2/ATP6V1C1/ITGAV/STX18/STX7/PIK3C3/ATP6V1H/TUBB2A/ATP6V0E2/THBS2/ATP6V1D/TUBB6/ATP6V1A/HLA-DOB	0.723514292453354
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	19/1958	78/9376	1.16644404284854	MINPP1/PTEN/MTMR2/MTM1/PPIP5K2/ALDH6A1/INPP1/IMPA2/OCRL/PIK3CA/PLCB3/IPMK/PIK3C3/ITPKA/IPPK/FIG4/MTMR6/PIP5K1B/MTMR14	0.75834941122292
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1958	47/9376	1.22261100123878	SOCS3/SOCS2/SOCS1/MAPK10/PIK3R3/PRKCD/PIK3CA/MAPK1/CACNA1G/MAPK8/CACNA1D/MAPK9	0.78600728787547
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	54/1958	238/9376	1.08647994437816	FGF2/RAP1B/CDC42/GNG4/CALM2/PDGFRA/TBK1/AKT1/RALB/RRAS/GNB2/PAK3/VEGFB/EFNA4/PRKCA/ABL1/MAPK10/CSF1/GNG5/SOS2/EPHA2/PIK3R3/MAP2K1/KITLG/EFNA5/SHC3/MAP2K2/PIK3CA/EXOC2/ARF6/RAP1A/MAPK1/RHOA/GNG12/RASA3/PDGFRB/NFKB1/FGFR1/MAPK8/NRAS/SOS1/MAPK9/ANGPT1/KRAS/ELK1/VEGFC/PLD1/FGF7/GNG11/PLA2G4C/PDGFC/PTPN11/RALA/CHUK	0.694267556195182
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1958	34/9376	1.26755993510785	SKP1/NFIL3/NR1D2/RBX1/PRKAA1/PRKAG1/PRKAB1/BHLHE40/BTRC	0.802951246120296
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	14/1958	56/9376	1.19713993871297	GAS1/BOC/CUL3/CCND2/MOSMO/EFCAB7/BCL2/CSNK1G2/SPOP/HHIP/GSK3B/EVC/BTRC/SPOPL	0.760167402006941
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	24/1958	101/9376	1.13787558531134	CALM2/GNAI3/CTNNB1/EDNRB/FZD2/ADCY3/WNT6/PRKCA/FZD1/MAP2K1/GNAI1/KITLG/MAP2K2/CAMK2D/PLCB3/MAPK1/GNAS/WNT2/NRAS/KRAS/CREB3L4/GSK3B/DVL3/FZD8	0.715714250211621
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1958	83/9376	1.15386982044624	TBK1/NFKBIA/CASP3/CASP7/CGAS/POLR2K/G3BP1/POLR1C/CASP8/POLR3F/POLR2H/IRF7/IFI16/FADD/MLKL/POLR3K/POLR3H/POLR1D/NFKB1/CHUK	0.723374328213104
NA	NA	hsa04519	Cadherin signaling	89/1958	404/9376	1.05490549054905	PCDH18/ACTG1/VIM/ARPC3/CDC42/ARPC1A/PPP1CB/KRT23/RYK/PDGFRA/MYO1B/YWHAQ/KRT10/NFKBIA/YAP1/PRICKLE2/CTNNB1/MOB1A/PPP1CC/RRAS/FAT4/STK3/PCDHGA12/BRK1/ACTR3/PCDHGB5/APH1B/FZD2/ARPC5L/WNT6/NCSTN/FZD1/MAPK10/PCDHB15/TEAD3/MAP2K1/GABRE/ARPC5/TMIE/TMC1/MAP2K2/ARPC1B/MPDZ/SAV1/PCDHGA4/PCDHB4/GABRA2/WTIP/PTK2/YWHAG/ENAH/MAP2K3/PCDHGA9/MAPK1/RHOA/PCDHB14/ACTN1/PCDHGA10/PDGFRB/ERBIN/NFKB1/WNT2/LIMA1/FGFR1/MAPK8/NRAS/VANGL1/MAPK9/KRAS/AJUBA/PSENEN/AMOTL2/WASF1/PCDHGB6/GJA1/PCDHB10/PCDH20/PKP2/PCDHB5/GSK3B/ADAM10/DVL3/ABI2/TEAD2/KRT34/PCDHGA3/FZD8/CHUK/CDH11	0.579576000518377
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	33/1958	144/9376	1.09737827715356	MYC/FGF2/AKT1/ID2/ID4/TBX3/SMARCAD1/KLF4/CTNNB1/ID3/MEIS1/PCGF5/FZD2/WNT6/FZD1/IL6ST/PIK3R3/MAP2K1/PCGF2/MAP2K2/PIK3CA/PCGF6/MAPK1/WNT2/SKIL/FGFR1/NRAS/KRAS/STAT3/GSK3B/DVL3/SMAD4/FZD8	0.604984157632869
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1958	67/9376	1.14353665787508	RAP1B/CALM2/PPP1CB/PPP1CC/PRKCA/MAP2K1/PPP3R1/MAP2K2/CAMK2D/PLCB3/RAP1A/MAPK1/PPP3CB/NRAS/KRAS/PPP3CC	0.605755384858114
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1958	99/9376	1.11249368042014	AKT1/MMP2/CDKN1B/ADCY3/MAPK10/MDM2/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/CDK4/PIK3CA/BCL2/PTK2/MAPK1/RPS6KB1/GNAS/MAPK8/NRAS/SOS1/MAPK9/KRAS	0.578083418084138
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	23/1958	99/9376	1.11249368042014	ACTG1/LAMA2/CACNA2D1/CACNA2D3/SGCB/SNTB1/CACNB2/ITGB5/ATP2A2/ITGA6/ITGA1/SLC8A1/ITGAV/LAMA1/PRKAA1/SGCE/CACNA1D/SSPN/PRKAG1/TPM4/PRKAB1/SNTB2/ITGB8	0.578083418084138
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1958	122/9376	1.0990137142283	MYC/ACTG1/RHEB/AKT1/CTNNB1/PFKM/STAT1/ATP2A2/PRKCA/ITGAV/HIF1A/MDM2/PIK3R3/HDAC1/MAP2K1/MAP2K2/ATP1A1/PIK3CA/MED30/PLCB3/MAPK1/MED13L/KAT2B/NRAS/KRAS/NCOA1/GSK3B/KAT2A	0.565534478520571
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/1958	36/9376	1.19713993871297	C1GALT1C1/C1GALT1/C1GALT1C1L/ST6GALNAC4/GALNT7/GCNT4/GALNT13/ST6GALNAC2/GALNT18	0.608836943327319
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1958	36/9376	1.19713993871297	PCNA/RNASEH1/RPA3/PRIM2/FEN1/RPA2/POLD4/PRIM1/MCM3	0.608836943327319
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/1958	45/9376	1.1705368289638	TAP1/ABCA8/TAP2/ABCA6/ABCC3/ABCD3/ABCA1/ABCA5/ABCC5/ABCC1/ABCB10	0.589126980650114
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	21/1958	91/9376	1.10505225111967	AKT1/NFKBIA/NFKBIE/BCL10/SOS2/PIK3R3/MAP2K1/PPP3R1/MAP2K2/PIK3CA/MAPK1/MALT1/PPP3CB/NFKB1/NRAS/SOS1/KRAS/PPP3CC/IFITM1/GSK3B/CHUK	0.517349069984467
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1958	23/9376	1.24918950126571	MME/ATP6AP2/PREP/ENPEP/LNPEP/NLN	0.61470501907522
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1958	41/9376	1.16794140362241	GCSH/PGAM1/DLD/MAOB/ALAS1/SHMT2/PSPH/BPGM/GCAT/AOC3	0.55365740553941
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/1958	41/9376	1.16794140362241	NBN/RAD50/BABAM2/RPA3/RAD51C/RAD51B/RPA2/ABRAXAS1/POLD4/MUS81	0.55365740553941
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1958	41/9376	1.16794140362241	MYC/MMP2/CXCL8/MDM2/MAP2K1/MAP2K2/CDK4/MAPK1/NRAS/KRAS	0.55365740553941
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	79/1958	362/9376	1.04501718406989	MYC/LAMA2/FGF2/LAMB1/GNG4/RHEB/PDGFRA/COL4A1/AKT1/YWHAQ/PTEN/TLR4/COL4A5/EIF4E/CDKN1B/COL4A4/COL1A2/CCND2/GNB2/VEGFB/HSP90AB1/DDIT4/ATF2/ITGB5/ITGA6/EFNA4/COL4A3/ITGA1/PRKCA/CSF1/ITGAV/GNG5/STK11/MDM2/SOS2/EPHA2/PIK3R3/MAP2K1/PPP2CB/KITLG/MCL1/EFNA5/LAMA1/MAP2K2/PRKAA1/CDK4/PIK3CA/BCL2/PTK2/YWHAG/PKN2/COL6A1/MAPK1/COL4A2/GNG12/RPS6KB1/PDGFRB/NFKB1/CSF3/EIF4B/THBS2/FGFR1/COL4A6/NRAS/SOS1/ANGPT1/ATF6B/KRAS/VEGFC/CREB3L4/FGF7/GSK3B/COL6A2/GNG11/IFNAR1/PDGFC/ITGB8/CHUK/CRTC2	0.448768537133265
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/1958	32/9376	1.19713993871297	PFKM/PGM2/GLA/PGM1/GALE/UGP2/B4GALT1/GLB1	0.573894098644085
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1958	10/9376	1.43656792645557	PAPSS1/SQOR/BPNT1	0.709615865347702
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/1958	73/9376	1.11514405249976	GADD45A/AKT1/GADD45G/FHIT/GADD45B/PRKCA/SOS2/PIK3R3/MAP2K1/MAP2K2/CDK4/PIK3CA/MAPK1/NRAS/SOS1/KRAS/STAT3	0.507387773011609
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	37/1958	166/9376	1.06732958391277	RGS2/ADRA2C/CALM2/PPP1CB/AKT1/GNAI3/PPP1CC/VDAC1/PPIF/VDAC2/EDNRB/ATF2/SLC25A5/ATP2A2/VDAC3/ADCY3/SLC8A1/PRKG1/BDKRB2/MAP2K1/GNAI1/PPP3R1/MAP2K2/ATP1A1/PLCB3/MAPK1/RHOA/PDE3A/PPP3CB/ATP2B1/CACNA1D/ATF6B/CREB3L4/PPP3CC/GNA13/NPR1/GNA12	0.449654275225836
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1958	115/9376	1.08263090109695	MMP16/GNAI3/PDE4B/ATF2/ADCY3/PRKCA/STK39/MAP2K1/GNAI1/JUND/WNK2/BCL2/NACA/PLCB3/MAPK1/RHOA/GNAS/CYP27B1/FGFR1/ATF6B/PLD1/CREB3L4/ARHGEF1/GNA13/GNA12/ARHGEF11	0.458048045473661
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1958	28/9376	1.19713993871297	ATP6V0E1/ATP6V1G1/ATP6V1C2/ATP6V1C1/ATP6V0E2/ATP6V1D/ATP6V1A	0.536713906813375
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1958	15/9376	1.2769492679605	SLC33A1/HEXA/ST6GALNAC4/GLB1	0.551484481211345
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1958	15/9376	1.2769492679605	NTPCR/NFS1/ACP1/THTPA	0.551484481211345
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	34/1958	154/9376	1.05721449133094	ACTG1/RGS2/CALM2/PPP1CB/CACNA2D1/CACNA2D3/GNAI3/PPP1CC/CACNB2/ADCY3/PRKCA/MAP2K1/GNAI1/CAMK1/PPP3R1/MAPK7/MAP2K2/PRKAA1/CAMK2D/PLCB3/PPP1R12B/MAPK1/RHOA/GNAS/PPP3CB/NRAS/CACNA1D/KRAS/ELK1/PPP3CC/PRKAG1/PRKAB1/PLA2G4C/NPR1	0.367792111450915
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1958	140/9376	1.0603239457172	SERPINE1/GNG4/CALM2/AKT1/MAP1LC3B/GNAI3/RRAS/GNB2/ADCY3/SLC8A1/GNG5/MAP2K1/GNAI1/PIK3R4/MAP2K2/PRKAA1/PLCB3/MAPK1/PLAT/PIK3C3/GNG12/RPS6KB1/TFAM/BECN1/NRAS/KRAS/PRKAG1/PRKAB1/GNA13/GNG11/SMAD4	0.369453992082712
Organismal Systems	Immune system	hsa04611	Platelet activation	28/1958	126/9376	1.06412438996709	ACTG1/MYL12B/RAP1B/PPP1CB/COL3A1/AKT1/MYL12A/GNAI3/COL1A2/PPP1CC/FGB/ADCY3/PRKG1/PIK3R3/GNAI1/PIK3CA/P2RY1/PLCB3/RAP1A/MAPK1/RHOA/GNAS/FYN/ARHGEF1/GNA13/PLA2G4C/STIM1/SNAP23	0.372294157000421
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/1958	75/9376	1.08540687776643	PGAM1/PFKM/IDH3A/RPIA/PRPS2/TKT/RPE/BCAT1/ACO1/TALDO1/SHMT2/PSPH/ALDH18A1/MAT2A/GOT1/PYCR2/PGK1	0.381511138940388
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1958	20/9376	1.19713993871297	HSD17B7/MSMO1/CYP51A1/CYP27B1/LIPA	0.453412068828841
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1958	212/9376	1.03902711661881	ACTG1/FGF2/RAP1B/CDC42/CALM2/PDGFRA/AKT1/PRKD3/PFN2/RALB/GNAI3/CTNNB1/RRAS/VEGFB/EFNA4/ADCY3/PRKCA/CSF1/PFN1/EPHA2/PIK3R3/MAP2K1/GNAI1/KITLG/EFNA5/MAP2K2/PIK3CA/PRKD1/P2RY1/PLCB3/ENAH/MAP2K3/RAP1A/BCAR1/MAPK1/RHOA/GNAS/PDGFRB/FGFR1/NRAS/ANGPT1/KRAS/VEGFC/FGF7/PDGFC/RALA	0.295284345729004
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1958	62/9376	1.08128768657946	ADAM17/APH1B/NCSTN/DTX1/HDAC1/DTX3L/MAML2/RFNG/TLE4/KAT2B/PSENEN/DTX3/KAT2A/DVL3	0.32991423844567
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1958	39/9376	1.10505225111967	MTHFS/GCSH/DLD/ALDH1L2/ATIC/GART/SHMT2/MAT2A/MTHFD2L	0.33774004328161
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1958	133/9376	1.04412205180981	COMT/GNG4/CALM2/PPP1CB/AKT1/GNAI3/MAOB/PPP1CC/GNB2/ATF2/PRKCA/MAPK10/GNG5/GNAI1/PPP2CB/GRIA3/CAMK2D/PLCB3/GNG12/GNAS/PPP3CB/MAPK8/CACNA1D/MAPK9/ATF6B/CREB3L4/PPP3CC/GSK3B/GNG11	0.263283481189078
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1958	44/9376	1.08830903519361	PCNA/PARG/MPG/PARP3/POLG2/PARP2/PARP4/FEN1/POLD4/NEIL2	0.301642603524122
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1958	110/9376	1.04477667378587	CDC26/AKT1/GNAI3/HSP90AB1/ADCY3/ANAPC13/CDC27/MAPK10/CDC23/ANAPC10/ANAPC7/PIK3R3/MAP2K1/GNAI1/PGR/PIK3CA/MAD1L1/ANAPC4/MAPK1/MAPK8/MAPK9/KRAS/CPEB1/CDC16	0.242689278846707
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	51/1958	238/9376	1.02611994746826	RPS7/OAS1/RPL22L1/RPL27/NRP1/RPS10/TBK1/OAS2/TLR4/NFKBIA/TNFRSF1A/RPL23A/CGAS/RPS21/CXCL8/CFD/RPL7A/FGB/STAT1/MX1/ADAM17/RPL32/PRKCA/MYD88/STAT2/FAU/MAPK10/IL6ST/PIK3R3/RPS13/RPS15A/RPL26L1/PIK3CA/IRAK4/RPL30/TRAF6/RSL24D1/RPL26/MAPK1/NFKB1/CSF3/MAPK8/MAPK9/EIF2AK2/RPS25/ISG15/STAT3/IFNAR1/RPL10A/CHUK/RPL14	0.209692920446842
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/1958	82/9376	1.05114726326017	CALR/HSPA5/HSPA1B/HSPA8/B2M/CANX/TAP1/HSPA1A/NFYB/HSPA4/PDIA3/TAP2/HLA-F/HLA-B/HSP90AB1/TAPBPL/PSME2/HLA-DOB	0.238988256207155
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	32/1958	150/9376	1.0215594143684	MYC/FGF2/GADD45A/AKT1/GADD45G/CDKN1B/CTNNB1/GADD45B/FZD2/WNT6/MLH1/FZD1/SOS2/PIK3R3/MAP2K1/SHC3/MAP2K2/PIK3CA/BCL2/MAPK1/RPS6KB1/WNT2/NRAS/SOS1/KRAS/FGF7/GSK3B/DVL3/TGFBR2/SMAD4/CDKN2B/FZD8	0.136749085750435
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1958	98/9376	1.02611994746826	CALM2/PTEN/PIP4P2/MTMR2/MTM1/PRKCA/PPIP5K2/PIK3R3/INPP1/IMPA2/OCRL/PIK3CA/PLCB3/IPMK/PIK3C3/ITPKA/IPPK/PIP4P1/MTMR6/PIP5K1B/MTMR14	0.133538569717682
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1958	17/9376	1.12671994231809	SCP2/CYP7B1/CYP39A1/HSD17B4	0.268660161230588
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1958	17/9376	1.12671994231809	GGT5/CSAD/CDO1/ADO	0.268660161230588
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/1958	65/9376	1.03138210104502	TRPC4/AKT1/PRKCA/TRPC1/PIK3R3/MAP2K1/MAP2K2/PIK3CA/PLCB3/MAPK1/CACNA1G/NRAS/CACNA1D/KRAS	0.130433485205673
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1958	51/9376	1.03282661379158	CHPT1/LPCAT4/PLA2G7/LPCAT2/SELENOI/PLPP3/AGPS/PLD1/PAFAH1B1/PLPP1/PLA2G4C	0.120763396987743
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1958	27/9376	1.06412438996709	HMGCS1/ALDH5A1/ECHS1/ACAT1/EHHADH/HADH	0.171423799289968
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	21/1958	99/9376	1.01575509951404	CALM2/PPP1CB/IL1R1/PPP1CC/BDKRB1/HTR2B/ADCY3/PRKCA/MAPK10/PIK3R3/BDKRB2/PRKCD/PIK3CA/CAMK2D/PLCB3/MAP2K3/CYP2J2/GNAS/MAPK8/MAPK9/PLA2G4C	0.0809624304700062
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1958	157/9376	1.00651255993702	MYC/ACTG1/SNAI2/SERPINE1/PPP1CB/YWHAQ/ID2/YAP1/FRMD6/CTNNB1/BMP2/MOB1A/PPP1CC/CCND2/STK3/FZD2/WNT6/FZD1/TEAD3/PPP2CB/SAV1/WTIP/YWHAG/WNT2/AJUBA/GSK3B/DVL3/TEAD2/TGFBR2/SMAD4/BTRC/FZD8/LLGL1	0.0422773949824595
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/1958	109/9376	1.01043004001462	IFNGR1/IL1R1/IFNGR2/NFKBIA/NFKBIE/HSP90AB1/STAT1/MAPK10/HIF1A/IL6ST/RARA/PPP3R1/MAPK1/PPP3CB/NFKB1/MAPK8/MAPK9/STAT3/PPP3CC/HLA-DOB/TGFBR2/SMAD4/CHUK	0.0562701677025095
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	29/1958	138/9376	1.00629154268627	SKP1/CALM2/PPP1CB/CDC26/YWHAQ/AR/PPP1CC/ADCY3/ANAPC13/CDC27/CDC23/ANAPC10/ANAPC7/RBX1/MAP2K1/PPP2CB/PPP3R1/PGR/CAMK2D/YWHAG/MAD1L1/ANAPC4/MAPK1/PPP3CB/PPP3CC/CPEB1/ESPL1/BTRC/CDC16	0.0382521877915623
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1958	37/9376	1.03536427131933	NIT2/GLS/GLUD1/PPAT/ALDH5A1/GFPT1/GOT1/GFPT2	0.110729657258088
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	31/1958	148/9376	1.0030091378406	MYC/FGF2/GADD45A/AKT1/PTEN/GADD45G/CTNNB1/GADD45B/FZD2/WNT6/FZD1/SOS2/PIK3R3/MAP2K1/PGR/SHC3/MAP2K2/CDK4/PIK3CA/MAPK1/RPS6KB1/WNT2/FGFR1/NRAS/SOS1/KRAS/NCOA1/FGF7/GSK3B/DVL3/FZD8	0.0189569172481769
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	22/1958	105/9376	1.00331728196897	ACTG1/LAMA2/CACNA2D1/CACNA2D3/SGCB/SNTB1/CACNB2/ITGB5/ATP2A2/ITGA6/ADCY3/ITGA1/SLC8A1/ITGAV/LAMA1/GNAS/SGCE/CACNA1D/SSPN/TPM4/SNTB2/ITGB8	0.0175615285694503
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1958	52/9376	1.01296456352636	VAPA/VDAC1/VDAC2/STARD3NL/MYLIP/VDAC3/ABCA1/NPC1/LIPA/ANGPTL4/LPL	0.0481622765309037
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1958	18/9376	1.06412438996709	HEXA/MANBA/NEU1/GLB1	0.139899623636655
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	24/1958	115/9376	0.999351601012568	DUSP1/GNG4/CASP3/GNAI3/MAOB/GNB2/KCND2/HTR2B/PRKCA/GNG5/TRPC1/MAP2K1/GNAI1/PLCB3/CYP2J2/MAPK1/GNG12/GNAS/NRAS/CACNA1D/KRAS/GNG11/PLA2G4C/ALOX15B	-0.00359427145217412
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1958	23/9376	1.04099125105476	B3GALNT2/B4GALT3/POMGNT1/B4GALT1/FUT4	0.101117934879064
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	38/1958	183/9376	0.994345741444655	RIOK2/RAN/AK6/NOP10/NXT1/RPP30/POP5/REXO2/SBDS/UTP18/WDR3/UTP14A/RPP25L/BMS1/EFL1/CSNK2B/UTP6/HEATR1/NOB1/NXT2/WDR36/GAR1/RPP40/EMG1/CSNK2A2/RIOK1/GNL3/POP7/UTP15/GTPBP4/POP1/XPO1/NAT10/WDR75/RPP38/MPHOSPH10/IMP3/EIF6	-0.039684521312284
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1958	28/9376	1.02611994746826	PTS/MOCS2/PCBD1/GGH/CBR1/QDPR	0.0711116131159099
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	45/1958	217/9376	0.993019304001544	MGST1/MYC/FGF2/PTGES3/GSTO1/MGST3/AKT1/AR/GNAI3/KLF4/CYP2B6/HSP90AB1/ATF2/KPNA2/ADCY3/PRKCA/SOS2/GSTM3/PIK3R3/MAP2K1/GNAI1/PGR/MAP2K2/PIK3CA/BCL2/MAPK1/RPS6KB1/GNAS/ARNT/GSTM5/NFKB1/EPHX2/NRAS/SOS1/CACNA1D/GSTT2B/ATF6B/KRAS/GSTA4/CREB3L4/STAT3/FGF7/GSTM2/KPNA4/CDC6	-0.0534506671449638
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/1958	116/9376	0.990736501003839	GNG4/GLS/GNAI3/GNB2/HOMER3/ADCY3/PRKCA/SLC38A2/GNG5/TRPC1/GNAI1/GRIA3/PPP3R1/PLCB3/MAPK1/GNG12/GNAS/PPP3CB/CACNA1D/PLD1/PPP3CC/GNG11/PLA2G4C/LZTS3	-0.0515759370931747
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/1958	87/9376	0.990736501003839	COX7A2L/CACNA2D1/CACNA2D3/UQCRFS1/CACNB2/ATP2A2/UQCRC2/COX6C/SLC8A1/UQCRH/ASPH/ATP1A1/COX8A/COX6A1/CACNA1D/COX7B/TPM4/SLC9A6	-0.0445962941254542
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	32/1958	155/9376	0.988605884872648	RAP1B/FH/RASD1/CDKN1B/GNAI3/CTNNB1/ATF2/FZD2/ADCY3/PDE8B/WNT6/FZD1/MAP2K1/GNAI1/MAP2K2/CDK4/CAMK2D/PLCB3/RAP1A/PBX1/MAPK1/GNAS/ARNT/CACNA1G/WNT2/CACNA1D/ATF6B/CREB3L4/GSK3B/DVL3/CDKN2B/FZD8	-0.0734862369530538
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	13/1958	63/9376	0.988115504969437	PTGES3/GGT5/PTGR1/CYP2B6/LTA4H/CBR1/CYP2U1/CYP2J2/CBR3/EPHX2/PLA2G4C/ALOX15B/PTGR2	-0.0486244580716978
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1958	63/9376	0.988115504969437	GADD45A/GADD45G/CTNNB1/BMP2/GADD45B/FZD2/WNT6/FZD1/WNT2/HHIP/GSK3B/DVL3/FZD8	-0.0486244580716978
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	25/1958	122/9376	0.981262244846699	RHEB/AKT1/PFKM/RAB10/HMGCR/ADIPOR1/CAB39/STK11/PIK3R3/PPP2CB/SIRT1/PRKAA1/PIK3CA/RAB8A/RPS6KB1/CAB39L/TBC1D1/SREBF1/CREB3L4/ACACB/PRKAG1/PRKAB1/FBP1/MLYCD/CRTC2	-0.107024028659652
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/1958	103/9376	0.976308299532909	CPB1/COL3A1/MME/COL4A1/COL4A5/COL4A4/COL21A1/COL1A2/COL5A2/SLC3A2/COL4A3/SLC8A1/SLC38A2/KCNE3/ATP1A1/COL6A1/COL4A2/SLC36A4/COL4A6/COL28A1/COL6A2	-0.1242090622983
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1958	104/9376	0.966920719729708	CHPT1/ETNK1/LPCAT4/SGMS2/PLPP5/PGS1/CRLS1/LPCAT2/LYPLA2/SELENOI/LYPLA1/PLPP3/LPGAT1/GPD2/GPAM/PTDSS2/PLD1/LPCAT3/PLPP1/PLA2G4C/CHKA	-0.174274793710921
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	34/1958	168/9376	0.969113283720025	MYC/IL15RA/IFNGR1/SOCS3/PDGFRA/IFNGR2/AKT1/IL13RA2/SOCS2/SOCS1/STAM/AOX1/CCND2/STAM2/STAT1/IL15/PIM1/STAT2/SOS2/IL6ST/PIK3R3/IL13RA1/MCL1/PIK3CA/BCL2/PDGFRB/CLCF1/CSF3/SOS1/STAT3/IFNAR1/PIAS2/PTPN11/IL19	-0.207535450333976
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1958	35/9376	0.957711950970378	PFKM/FPGT/TIGAR/MPI/FBP1/GMPPB/HSD17B14	-0.12876669615769
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	14/1958	70/9376	0.957711950970378	MGST1/GSTO1/MGST3/HSD11B1/NAT1/CYP2A7/GSTM3/GSTK1/CBR1/GSTM5/GSTT2B/GSTA4/AKR1C2/GSTM2	-0.182445733851191
Genetic Information Processing	Transcription	hsa03040	Spliceosome	49/1958	243/9376	0.965594353859023	SRSF9/HSPA1B/HSPA8/EIF4A3/SNRPA1/LSM6/HSPA1A/SF3B6/SRSF7/SNRNP40/DDX5/LSM8/SRSF1/PPIL1/DDX39B/TRA2A/PHF5A/BCAS2/PLRG1/LSM5/SNRPF/SRSF6/HNRNPA3/SRSF8/SRSF2/ALYREF/MAGOHB/LSM2/SRSF10/THOC7/SF3B1/PRPF38A/USP39/SNRPE/LSM4/HNRNPA1/MAGOH/THOC6/THOC1/SF3A3/BUD31/AQR/NCBP1/THOC3/SMNDC1/PRPF31/SF3B5/SNRPB2/PPIH	-0.279173822958431
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1958	76/9376	0.945110477931294	SCP2/HMGCS1/PLIN2/DBI/ME1/ACSL1/UBC/ACOX1/ACADM/EHHADH/ACSL5/ME3/ANGPTL4/LPL/PPARD	-0.246833066487481
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1958	46/9376	0.936892125949283	ALAD/CPOX/HMBS/ALAS1/HEPH/HCCS/FXN/EARS2/COX15	-0.220429751733126
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/1958	116/9376	0.949455813462013	ACTG1/VCAM1/MYL12B/RAP1B/CLDN20/CDC42/MYL12A/MMP2/GNAI3/CTNNB1/PRKCA/PIK3R3/GNAI1/JAM3/CLDN23/PIK3CA/PTK2/RAP1A/BCAR1/RHOA/ACTN1/CLDN12/PTPN11	-0.281412432428538
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1958	36/9376	0.931108841221201	ENPP1/PGM2/GBE1/PGM1/PYGL/UGP2/GYG1	-0.212759945077538
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	19/1958	97/9376	0.93796531280604	GNG4/RASD1/CALM2/GNAI3/GNB2/ADCY3/PRKCA/GNG5/PRKG1/GNAI1/GRIA3/CAMK2D/PLCB3/MAPK1/GNG12/GNAS/CACNA1G/CACNA1D/GNG11	-0.315513861482607
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1958	37/9376	0.905943737404412	COMT/ADH5/AOX1/MAOB/FAHD1/GOT1/AOC3	-0.294501125900315
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1958	16/9376	0.897854954034729	MAOB/GOT1/AOC3	-0.210081564305425
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/1958	88/9376	0.92506267991457	F3/PLAU/SERPINE1/CD46/PROCR/CFH/CFD/BDKRB1/FGB/CD55/PLAUR/SERPIND1/SERPINB2/BDKRB2/CFI/PLAT/TFPI	-0.362849858375705
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/1958	78/9376	0.920876875933056	IFNGR1/MARCKSL1/IFNGR2/TLR4/NFKBIA/STAT1/MYD88/IL1A/EEF1A1/IRAK4/TRAF6/MAPK1/NFKB1/ELK1/HLA-DOB	-0.360499381794561
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	14/1958	73/9376	0.918353925588034	MGST1/GSTO1/ADH5/MGST3/AOX1/MAOB/CYP2A7/CYP2B6/GSTM3/GSTK1/GSTM5/GSTT2B/GSTA4/GSTM2	-0.359777330844907
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1958	48/9376	0.897854954034729	CLDN20/LAMP2/TSG101/LAMP1/PDCD6IP/CHMP7/CLDN23/CLDN12/CHMP1B	-0.364495545869866
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	17/1958	89/9376	0.9146687172189	GNG4/GLS/GNAI3/GNB2/NSF/GABARAPL2/ADCY3/PRKCA/SLC38A2/GNG5/GNAI1/GABRE/GABRA2/GNG12/CACNA1D/GNG11/PLCL1	-0.415541231377712
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/1958	79/9376	0.909220206617448	MGST1/GSTO1/ADH5/MGST3/HSD11B1/CYP2A7/CYP2B6/GSTM3/GSTK1/CBR1/GSTM5/CBR3/GSTT2B/GSTA4/GSTM2	-0.416274576397119
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1958	115/9376	0.916072300928188	GNG4/AKT1/GNAI3/GNB2/ADCY3/PRKCA/GNG5/PIK3R3/MAP2K1/GNAI1/PIK3CA/BCL2/CAMK2D/PLCB3/MAPK1/GNG12/FYN/NRAS/CACNA1D/KRAS/CREB3L4/GNG11	-0.465236588378009
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/1958	95/9376	0.907306058814042	CXCL1/ATP6V0E1/ATP6V1G1/CXCL5/CTSK/TLR4/CXCL8/IL15/ATP6V1C2/ATP6V1C1/IL1A/CSF1/ATP6V1H/ATP6V0E2/ATP6V1D/ANGPT1/ATP6V1A/HLA-DOB	-0.466513624432193
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1958	17/9376	0.845039956738569	LAMP2/LAMP1/PCDH20	-0.328532269233612
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1958	75/9376	0.893864487572353	HSPA5/CANX/GSR/GPX8/ATF2/ADCY3/PRKCA/PDIA4/ATP1A1/PLCB3/TTF2/GNAS/ATF6B/CREB3L4	-0.474105614058754
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	39/1958	201/9376	0.929123534523501	MYC/CEBPB/PLAU/GADD45A/HOXA11/DDX5/HOXA10/ID2/GADD45G/CDKN1B/CXCL8/CCND2/MEIS1/GADD45B/CDK9/PRCC/MDM2/HDAC1/RARA/DDIT3/CDK14/GRIA3/NFKBIZ/FUT8/PTK2/HOXA9/ZBTB17/MLF1/SUPT3H/PBX1/PLAT/ETV7/NFKB1/MAX/RUNX1T1/MLLT3/CCNT2/SS18L1/TGFBR2	-0.521849908150808
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1958	91/9376	0.894566108049254	GNG4/GNAI3/PDE1A/PDE4B/GNB2/ADCY3/PDE8B/PRKCA/GNG5/GNAI1/GABRE/GABRA2/PDE3A/GNG12/GNAS/GRK4/GNG11	-0.519228530223753
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1958	23/9376	0.832793000843807	MDH1/GLS/GLUD1/ATP1A1	-0.412469149317091
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/1958	193/9376	0.918014046266942	CXCL1/RAP1B/CDC42/GNG4/CXCL5/AKT1/NFKBIA/GNAI3/CXCL8/GNB2/STAT1/ADCY3/STAT2/GNG5/SOS2/PIK3R3/MAP2K1/GNAI1/SHC3/PRKCD/PIK3CA/PTK2/PLCB3/RAP1A/BCAR1/MAPK1/RHOA/GNG12/NFKB1/NRAS/SOS1/KRAS/GRK4/STAT3/GSK3B/GNG11/CHUK	-0.591254396215756
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1958	12/9376	0.798093292475315	CD46/NPC1	-0.359549951734408
NA	NA	hsa04517	IgSF CAM signaling	57/1958	299/9376	0.912869250924942	ACTG1/MYL12B/DYNLL1/ARPC3/RAP1B/TUBA3D/CDC42/ARPC1A/NRP1/UNC5C/AKT1/MYL12A/CTNNB1/PAK3/FGB/NCK1/ACTR3/ARPC5L/PRKCA/ABL1/NLGN1/MAPK10/PMP22/CNTNAP1/ROBO1/PIK3R3/MAP2K1/UNC5B/JAM3/ARPC5/MAP2K2/ARPC1B/MPDZ/PIK3CA/PTK2/TRAF6/ARF6/RAP1A/BCAR1/MAPK1/RHOA/ACTN1/NCK2/DOK1/TUBB2A/TRIO/FGFR1/FYN/MAPK8/MAPK9/TUBB6/WASL/CASK/GSK3B/PTPN11/NECTIN2/NECTIN3	-0.786655243121008
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/1958	69/9376	0.832793000843807	CALM2/GNAI3/PDE1A/GNAI1/PPP3R1/PLCB3/PDE3A/GNAS/PPP3CB/CACNA1D/PPP3CC/NPR1	-0.716180857187877
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1958	53/9376	0.813151656484283	CLTA/SLC8A1/PRKCA/BDKRB2/ATP1A1/PLCB3/GNAS/ATP2B1/AP2M1	-0.700806162527001
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1958	31/9376	0.772348347556756	ALDH2/ALDH3A2/ALDH9A1/UGDH/HSD17B14	-0.652244714628299
NA	NA	hsa04981	Folate transport and metabolism	5/1958	31/9376	0.772348347556756	MTHFS/ABCC3/SHMT2/ABCC5/ABCC1	-0.652244714628299
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1958	59/9376	0.811620297432524	AKT1/GNAI3/ABHD5/ADCY3/PRKG1/PIK3R3/GNAI1/PIK3CA/GNAS/NPR1	-0.74571114241809
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/1958	133/9376	0.864101008394326	FAS/IFNGR1/IFNGR2/CASP3/HLA-B/BID/PRKCA/SOS2/PIK3R3/MAP2K1/PPP3R1/SHC3/MAP2K2/PIK3CA/MICA/MAPK1/PPP3CB/FYN/NRAS/SOS1/KRAS/PPP3CC/IFNAR1/PTPN11	-0.810931453375239
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1958	49/9376	0.781805674261533	GNAI3/MAOB/ATF2/GNAI1/GNAS/NFKB1/ATF6B/CREB3L4	-0.786717971967399
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1958	38/9376	0.756088382345035	PRKCA/PIK3R3/ATP1A1/PIK3CA/MAPK1/KRAS	-0.774008834019645
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1958	98/9376	0.830668528902879	CALM2/PRKD3/ATF2/ADCY3/PRKCA/CAMK1/ATP1A1/CAMK2D/PRKD1/PLCB3/GNAS/CACNA1G/ATP2B1/CACNA1D/ATF6B/CREB3L4/NPR1	-0.865709339039686
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/1958	44/9376	0.761816324635528	FAS/HLA-F/HSPD1/HLA-B/IL1A/PTPRN2/HLA-DOB	-0.813578630956229
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1958	44/9376	0.761816324635528	DYNLL1/DCTN6/NSF/DYNC2LI1/ADCY3/GNAS/CREB3L4	-0.813578630956229
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/1958	233/9376	0.883725619994126	DCN/ACTG1/VIM/LAMA2/FBLN2/SDC4/COL3A1/CAPZA2/SYNPO2/COL4A1/CSRP1/PDLIM1/COL4A5/COL4A4/SDC2/COL1A2/COL5A2/VCAN/SGCB/SNTB1/ITGB5/TMEM43/ITGA6/COL4A3/ITGA1/CAPZB/ITGAV/CAPZA1/LAMA1/ATP1A1/SYNE1/COL6A1/COL4A2/SGCE/TMOD2/THBS2/COL4A6/SSPN/PKP2/TPM4/SNTB2/COL6A2/ITGB8	-0.923349674711573
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/1958	93/9376	0.823838237393874	IFNGR1/IFNGR2/NFKBIA/NFKBIE/STAT1/MAPK10/PPP3R1/MAML2/MAPK1/PPP3CB/NFKB1/MAPK8/MAPK9/PPP3CC/HLA-DOB/CHUK	-0.877116969851886
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1958	61/9376	0.785009795877359	CYBRD1/SLC8A1/HEPH/MT2A/ATP1A1/MT1X/SLC11A2/SLC30A1/ATP2B1/MT1M	-0.865447499290657
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	11/1958	68/9376	0.774619960343688	ALDH1A1/ADH5/ALDH1A3/AOX1/CYP2A7/RDH12/CYP2B6/RDH10/HSD17B6/RDH11/PNPLA4	-0.958275285229187
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1958	16/9376	0.598569969356486	HEXA/GLA	-0.825620547720322
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1958	134/9376	0.821916972847712	AVPR1A/CALCRL/CALM2/PPP1CB/PPP1CC/ADCY3/PRKCA/PRKG1/MAP2K1/PRKCD/MAP2K2/PLCB3/PPP1R12B/MAPK1/RHOA/GNAS/CACNA1D/ARHGEF1/GNA13/PLA2G4C/NPR1/GNA12/ARHGEF11	-1.06669562524297
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1958	23/9376	0.624594750632855	GLS/GLUD1/GOT1	-0.926056233513247
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1958	65/9376	0.736701500746445	ATF2/ADCY3/PDE8B/PLCB3/PBX1/GNAS/CACNA1G/CACNA1D/ATF6B/CREB3L4	-1.09434804437709
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	10/1958	66/9376	0.725539356795741	COMT/HSD17B7/HSD11B1/CYP7B1/HSD17B6/SRD5A3/AKR1C2/SULT1E1/SRD5A1/HSD17B11	-1.1495444565989
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1958	37/9376	0.64710266957458	VCAM1/FAS/PRKCA/MYD88/PLCB3	-1.10496269221712
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	26/1958	154/9376	0.80845814042954	CALM2/PPP1CB/CACNA2D1/AKT1/CACNA2D3/GNAI3/PPP1CC/CACNB2/ATF2/ATP2A2/ADCY3/SLC8A1/PRKCA/GNAI1/PPP2CB/ATP1A1/BCL2/CAMK2D/PLCB3/MAPK1/GNAS/ATP2B1/CACNA1D/ATF6B/CREB3L4/TPM4	-1.23128919481562
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1958	50/9376	0.670398365679265	VCAM1/TLR4/SDC2/CXCL8/MYD88/CSF3/THBS2	-1.20053609096847
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1958	26/9376	0.552526125559833	LMBRD1/SLC19A2/ABCC1	-1.17380814920085
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1958	65/9376	0.6630313506718	PLPP5/GLA/ALDH2/PLPP3/ALDH3A2/ALDH9A1/GPAM/PLPP1/LPL	-1.40054342677279
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1958	28/9376	0.513059973734131	B4GALT3/B4GALT1/FUT4	-1.32569526797649
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1958	48/9376	0.598569969356486	AKT1/PIK3R3/ATP1A1/PIK3CA/PLCB3/CACNA1D	-1.43246749526857
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/1958	102/9376	0.704199963948807	RAB27B/CPB1/RAP1B/BST1/ATP2A2/ADCY3/PRKCA/TRPC1/ATP1A1/RAB8A/PLCB3/RAP1A/RHOA/GNAS/ATP2B1	-1.54316843056862
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/1958	79/9376	0.666761484852795	ATP6V0E1/ATP6V1G1/CLTA/NSF/ATP6V1C2/ATP6V1C1/ATP6V1H/ATP6V0E2/ATP6V1D/AP2M1/ATP6V1A	-1.52807928464363
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	42/1958	254/9376	0.791809093321966	FGF2/AVPR1A/CALM2/PDGFRA/PHKG1/PDE1A/VDAC1/PPIF/BDKRB1/VDAC2/EDNRB/VEGFB/SLC25A5/ATP2A2/HTR2B/STIM2/VDAC3/ADCY3/SLC8A1/PRKCA/MCU/BDKRB2/ASPH/CAMK1/PPP3R1/CAMK2D/PLCB3/GNAS/ITPKA/CACNA1G/PPP3CB/ORAI3/PDGFRB/MST1/ATP2B1/FGFR1/CACNA1D/VEGFC/PPP3CC/FGF7/STIM1/PDGFC	-1.72815283587933
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1958	76/9376	0.630073651954196	ACTG1/CALM2/GNAI3/ADCY3/PRKCA/GNAI1/ATP1A1/CAMK2D/PLCB3/GNAS	-1.66352431978488
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1958	38/9376	0.504058921563357	TAP1/TAP2/DCLRE1C/ADA	-1.57377815601305
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1958	45/9376	0.532062194983543	FAS/HLA-F/HLA-B/IL1A/HLA-DOB	-1.61651174046348
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1958	52/9376	0.552526125559833	HSD17B7/ADCY3/ACOT2/CYP2J2/GNAS/PLA2G4C	-1.66232827177876
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1958	39/9376	0.491134333830963	FAS/HLA-F/HLA-B/HLA-DOB	-1.63598885587594
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/1958	160/9376	0.718283963227783	VCAM1/CLDN20/SDC4/SDC2/HLA-F/VCAN/HLA-B/ITGA6/NLGN1/ITGAV/CNTNAP1/PTPRM/JAM3/CLDN23/NEGR1/CD276/PDCD1LG2/CLDN12/NEO1/HLA-DOB/NRXN3/NECTIN2/ITGB8/NECTIN3	-1.84649823032827
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1958	66/9376	0.580431485436593	IFNGR1/IFNGR2/TLR4/STAT1/IL1A/NFKB1/STAT3/HLA-DOB	-1.75731082769799
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1958	17/9376	0.281679985579523	GLUD1	-1.52291713016201
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/1958	86/9376	0.612490201201986	ATF2/RIMS2/ADCY3/PRKCA/ATP1A1/CAMK2D/PLCB3/GNAS/CACNA1D/ATF6B/CREB3L4	-1.85469552825266
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1958	26/9376	0.368350750373222	ACOX1/PLA2G4C	-1.65693480446455
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	35/1958	226/9376	0.741591112477063	RAP1B/CALM2/PPP1CB/AKT1/NFKBIA/GNAI3/PDE4B/PPP1CC/RRAS/ATP2A2/ADCY3/MAPK10/PIK3R3/MAP2K1/GNAI1/GRIA3/MAP2K2/ATP1A1/PIK3CA/CAMK2D/RAP1A/MAPK1/RHOA/PDE3A/GNAS/NFKB1/ACOX1/ATP2B1/MAPK8/CACNA1D/MAPK9/HHIP/PLD1/CREB3L4/NPR1	-2.02022474518059
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1958	43/9376	0.44544741905599	PLPP3/ABCA1/ACAT1/PLPP1	-1.87247010722805
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1958	36/9376	0.399046646237657	RPE/UGP2/UGDH	-1.85595372188725
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1958	29/9376	0.330245500334613	CALM2/PDE6B	-1.85578254303573
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1958	30/9376	0.319237316990126	CYP2J2/PLA2G4C	-1.9186336085514
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/1958	100/9376	0.574627170582227	MME/IL1R1/ITGA6/CD55/ITGA1/CD44/IL1A/CSF1/KITLG/CD1D/CSF3/HLA-DOB	-2.19703989660726
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1958	41/9376	0.350382421086724	GABRE/GRIA3/GABRA2	-2.14161353648422
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1958	93/9376	0.514898898371171	CALM2/BST1/PRH1/ADCY3/PRKCA/PRKG1/ATP1A1/PLCB3/GNAS/ATP2B1	-2.41533918619915
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	48/1958	323/9376	0.711612595148268	MYC/VIM/PLAU/PDGFRA/GLS/PTEN/CASP3/SOCS1/MMP16/CDKN1B/CCND2/DDIT4/PIM1/EFNA4/PRKCA/ABL1/MARCKS/CD44/UBE2I/MDM2/SOS2/PIK3R3/HDAC1/MAP2K1/CCNG1/SIRT1/MCL1/EFNA5/MAPK7/MAP2K2/PIK3CA/BCL2/MAPK1/ZFPM2/RHOA/BCL2L2/PDGFRB/NFKB1/MDM4/RECK/NRAS/SOS1/KRAS/ABCC1/STAT3/FSCN1/HOXD10/SOX4	-2.70975394560799
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1958	191/9376	0.626774837022499	GNG4/CALM2/PPP1CB/GNAI3/MAOB/PPP1CC/GNB2/ATF2/HAT1/GNG5/SOS2/HDAC1/MAP2K1/GNAI1/HDAC8/SHC3/MAPK1/GNG12/GNAS/NRAS/SOS1/ATF6B/KRAS/CREB3L4/GNG11	-2.67729722033468
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1958	54/9376	0.354708129989029	FAS/HLA-F/HLA-B/HLA-DOB	-2.44313289691718
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1958	50/9376	0.287313585291113	IL15RA/IL15/HLA-DOB	-2.5958783977641
Human Diseases	Immune disease	hsa05310	Asthma	1/1958	32/9376	0.149642492339122	HLA-DOB	-2.47547584000622
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/1958	100/9376	0.43097037793667	CXCL1/CXCL5/TNFRSF1A/ACKR3/CXCL8/CSF1/IL6ST/ACKR4/IL19	-2.93902359428002
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1958	86/9376	0.389766491673991	PDE1A/TAS2R1/SCN2A/GABRA2/P2RY1/PLCB3/TAS2R14	-2.92069352205496
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1958	194/9376	0.567715847224708	ACTG1/MYL12B/DYNLL1/DYNLT3/TUBA3D/CAPZA2/MYO1B/ACTR10/MYL12A/DCTN6/DYNLT1/TUBE1/DYNC2LI1/CAPZB/KIF2A/CAPZA1/DNAH11/DNAL4/ACTR1B/TUBB2A/TUBD1/TUBB6/TPM4	-3.12572022662216
NA	NA	hsa04081	Hormone signaling	25/1958	219/9376	0.546639241421449	AVPR1A/GNG4/ADRA2C/GNAI3/GNB2/ADIPOR1/ADCY3/ITGAV/GNG5/STK11/PRKG1/PIK3R3/GNAI1/HEPH/PIK3CA/PLCB3/RHOA/GNG12/GNAS/STAT3/GNA13/GNG11/SMAD4/NPR1/GNA12	-3.48769054567832
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1958	195/9376	0.515691050522511	ACTG1/AKT1/TLR4/VDAC1/PPIF/VDAC2/FGB/SLC25A5/HAT1/VDAC3/PRKCA/PIK3R3/HDAC1/MAP2K1/HDAC8/MAP2K2/PIK3CA/PLCB3/MAPK1/NFKB1/CASP4	-3.5111014146693
NA	NA	hsa04382	Cornified envelope formation	24/1958	217/9376	0.52961029546749	CLDN20/KRT23/COL4A1/KRT10/COL4A5/COL4A4/SPTLC1/ABHD5/ITGA6/S100A16/COL4A3/PPP2CB/CLDN23/ELOVL4/COL4A2/BLMH/EPHX2/KDSR/S100A4/COL4A6/PKP2/CLDN12/TGM1/KRT34	-3.60173878520798
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1958	99/9376	0.338585033171346	KRT23/KRT10/CFH/CFD/CFI/HLA-DOB/KRT34	-3.39888448282892
NA	NA	hsa04082	Neuroactive ligand signaling	21/1958	199/9376	0.505325401265777	OGFRL1/P2RY14/GNG4/ADRA2C/GNAI3/GNB2/HTR2B/ADCY3/PRKCA/GNG5/GNAI1/GABRE/GRIA3/GABRA2/P2RY1/PLCB3/GNG12/GNAS/GNG11/GLRB/SLC17A9	-3.62363420044113
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1958	90/9376	0.266031097491772	HMGCR/ADCY3/ABCC3/ATP1A1/GNAS	-3.594455755403
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	25/1958	298/9376	0.401724811648648	IL15RA/TNFRSF12A/FAS/CXCL1/IFNGR1/CXCL5/IL1R1/IFNGR2/IL13RA2/TNFRSF1A/ACKR3/CXCL8/BMP2/TNFSF12/IL15/IL1A/CSF1/IL6ST/IL13RA1/CLCF1/CSF3/ACKR4/IFNAR1/TGFBR2/IL19	-5.39215791448093
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1958	143/9376	0.133945727408444	TRIM21/SSB/ACTN1/HLA-DOB	-5.36154896975721
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1958	370/9376	0.220014907655357	OGFRL1/AVPR1A/CALCRL/P2RY14/ADRA2C/S1PR3/GAL/BDKRB1/EDNRB/PGRMC1/HTR2B/BDKRB2/GABRE/GRIA3/GABRA2/P2RY1/GLRB	-7.86447543739426
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1958	449/9376	0.0746546064230807	RGS2/CALM2/PDE1A/ADCY3/SLC8A1/PRKG1/CAMK2D	-10.323401965148