category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	69/1948	122/9376	2.72218669000572	ITK/PTPRC/PPP2R5C/LCK/MALT1/CD247/KRAS/PPP2R5A/PPP3CA/CDC42/MAPK1/NFKB1/CBLB/CTLA4/BCL10/SOS2/PPP3CC/PPP2R2A/NCK1/CARD11/LCP2/PIK3CD/PPP2CA/VAV3/PPP2R3C/ZAP70/MAP3K8/PRKCQ/LAT/VAV1/TEC1/ICOS/MAP2K2/SOS1/PIK3CA/PPP3R1/MAPK13/PPP2R2D/GRAP2/IKBKB/RASGRP1/MAPK8/PAK2/IFNG/PPP2R2B/CD8B/AKT1/CD8A/PLCG1/NFATC3/RELA/MAP2K1/NFKBIE/NCK2/CD3G/CD3E/PIK3R1/CD28/PPP3CB/NFATC1/MAP3K7/CHUK/NFATC2/RAF1/MAP3K14/FYN/DLG1/PDPK1/MAPK9	9.8048185997227
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	60/1948	108/9376	2.67396760209902	DDX39B/NUP98/PNN/EIF4A3/SUMO1/XPO1/NUP58/THOC3/KPNA4/RANBP2/MAGOH/ACIN1/RNPS1/NUP153/PHAX/NUP54/SUMO4/KPNA2/NXT1/RAN/NUP210/NCBP2/UBE2I/RBM8A/NUP205/NUP50/NUP88/SUMO2/SENP2/NUP107/NCBP1/KPNA5/AHCTF1/SAP18/THOC1/TPR/ALYREF/NXF1/NMD3/UPF1/KPNA1/THOC7/XPO4/NUP160/TNPO1/IPO8/SRRM1/CASC3/IPO7/XPOT/MAGOHB/TMEM33/POM121C/NUP188/NUP62/RANBP17/NUP43/SEH1L/THOC5/XPO5	8.96004272477385
Human Diseases	Infectious disease: viral	hsa05162	Measles	68/1948	136/9376	2.40657084188912	HSPA1A/CASP3/CASP8/HSPA1B/HSPA8/MX1/ADAR/IRF7/OAS2/EIF2AK2/HSPA6/CDKN1B/OAS1/CYCS/IRF9/CCND3/STAT3/CCND2/STAT1/JAK3/NFKB1/CBLB/IL2RB/BCL2/MSN/RAB9A/STAT2/OAS3/PIK3CD/MX2/CD46/JAK1/TBK1/EIF3H/FASLG/SLAMF1/CSNK2A1/PIK3CA/IRF3/TRAF3/EIF2S1/IKBKB/TRAF6/IFIH1/RCHY1/MAPK8/APAF1/BBC3/AKT1/FAS/RELA/IKBKE/BID/BAK1/CD3G/CD3E/IRAK4/TNFAIP3/STAT5B/PIK3R1/CD28/IL2RG/MAP3K7/CHUK/TYK2/CASP9/CSNK2A2/MAPK9	8.46134193344756
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	67/1948	142/9376	2.27098938600804	SOCS1/CUL3/UBE2B/UBE2A/UBE2D3/UBE2S/CBLB/FBXW7/BIRC6/MDM2/VHL/HERC1/BIRC2/UBA6/UBA2/TRIP12/RNF7/UBE2N/UBB/HUWE1/ANAPC5/UBE2I/UBE3A/UBE4A/HERC4/CUL2/ITCH/UBE2G1/UBE2D2/SKP1/UBE2H/UBE2J1/HERC2/CBL/CUL5/UBE3C/ANAPC16/TRAF6/UBE2L6/ANAPC10/ANAPC4/RCHY1/ANAPC1/CDC26/SIAH1/UBA3/CUL1/UBR5/UBE2Z/UBE2Q1/SAE1/BIRC3/PIAS1/MAP3K1/HERC3/PPIL2/UBE2M/SMURF2/UBE2Q2/SOCS3/UBE2E3/PIAS3/BTRC/UBE2F/COP1/WWP1/PIAS2	7.81511418542363
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	71/1948	157/9376	2.17664369139016	ATM/PPP1CB/CCND3/KRAS/PPID/ETS1/PPP3CA/CCND2/TRPM7/MAPK1/NFKB1/HIPK1/MDM2/PTEN/PPP3CC/SIRT1/PPP1CC/KIR2DL4/RBBP4/HLA-F/ZFP36L2/PIK3CD/VDAC3/ATR/RBL2/SLC25A5/HLA-B/VDAC2/TGFBR2/CAPN2/LIN54/RASSF5/HUS1/MAP2K2/GADD45A/PIK3CA/PPP3R1/RBL1/MAPK13/CALM1/NBN/HIPK3/MAP2K6/ITPR1/AKT1/NFATC3/RHEB/RELA/TGFB1/HLA-A/MAP2K1/TSC2/MAP2K3/RB1/MRE11/PIK3R1/ITPR3/PPP3CB/CALM2/E2F4/NFATC1/RRAS2/E2F3/CDKN2B/NFATC2/TSC1/RAF1/RAD9A/MCU/BTRC/ITPR2	7.61372271805078
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	78/1948	180/9376	2.08569472963723	SRSF5/CASP3/CASP8/ZC3HAV1/SRSF7/SRSF6/IRF7/OAS2/SRSF2/EIF2AK2/BST2/OAS1/CYCS/PILRB/PPP1CB/CGAS/SP100/IRF9/IFNGR1/SRSF3/TAP1/B2M/TRAF5/CALR/STAT1/SRSF9/NFKB1/EIF2B1/PPP1CC/BCL2/BIRC2/HLA-F/STAT2/OAS3/SRSF4/PIK3CD/SRSF1/HLA-B/JAK1/TBK1/TAP2/FASLG/PIK3CA/SRSF8/IRF3/TRAF3/EIF2S1/EIF2B5/IKBKB/TRAF6/IFIH1/APAF1/IFNG/PDIA3/SRPK1/ALYREF/NXF1/AKT1/FAS/RHEB/RELA/HLA-A/IKBKE/TSC2/BIRC3/BID/BAK1/IRAK4/PIK3R1/CCL5/HCFC1/MAP3K7/CHUK/TYK2/TSC1/SOCS3/CASP9/TAB1	7.53162464378348
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	88/1948	214/9376	1.9792358325817	CASP3/CASP8/APOBEC3G/CXCR4/ATM/BST2/CYCS/GNG2/RAC2/CGAS/CD247/TAP1/KRAS/B2M/PLCG2/TRAF5/PPP3CA/MAPK1/CALR/GNAI3/NFKB1/PPP3CC/RPS6KB1/BCL2/SAMHD1/HLA-F/RNF7/AP1G1/PIK3CD/PRKCA/ATR/TRIM5/HLA-B/TBK1/APOBEC3C/TAP2/SKP1/MAP2K2/FASLG/CCR5/PIK3CA/PPP3R1/IRF3/APOBEC3D/CUL5/MAPK13/CALM1/IKBKB/TRAF6/MAPK8/PAK2/MAP2K6/ITPR1/PDIA3/CUL1/AKT1/GNG5/PLCG1/FAS/GNB5/NFATC3/RELA/HLA-A/MAP2K1/BID/BAK1/CD3G/CD3E/MAP2K3/IRAK4/PIK3R1/ITPR3/PPP3CB/CALM2/NFATC1/MAP3K7/CHUK/GNGT2/NFATC2/CRKL/RAF1/AP1G2/BTRC/CASP9/DCAF1/ITPR2/TAB1/MAPK9	7.42067150499197
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	84/1948	205/9376	1.97221415335303	CASP3/CASP8/PSMD12/IRF7/OAS2/EIF2AK2/CDKN1B/BCL2L11/OAS1/CYCS/IRF9/CCND3/CD247/TAP1/STAT3/B2M/PLCG2/TRAF5/CCND2/CALR/STAT1/JAK3/NFKB1/MDM2/CD58/BCL2/HLA-F/PSMD6/STAT2/PSMC6/OAS3/SIN3A/PIK3CD/PSMC4/PSMD13/HLA-B/PSMD11/JAK1/TBK1/CIR1/TAP2/GADD45A/PIK3CA/IRF3/SNW1/TRAF3/MAPK13/IKBKB/TRAF6/SAP30/MAPK8/APAF1/NFKB2/USP7/MAP2K6/PDIA3/AKT1/FAS/RUNX3/RELA/HLA-A/IKBKE/HDAC1/NFKBIE/BID/BAK1/CD3G/CD3E/CD44/MAP2K3/IRAK4/RB1/PSMC2/TNFAIP3/PIK3R1/ISG15/MAP3K7/E2F3/CHUK/TYK2/MAP3K14/CASP9/TAB1/MAPK9	7.20733468803871
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	47/1948	90/9376	2.51352954597308	LCK/IFNGR1/CD247/KRAS/STAT3/PPP3CA/HIF1A/MAPK1/STAT1/NFKB1/PTEN/PPP3CC/RPS6KB1/BATF/PIK3CD/ZAP70/PRKCQ/LAT/JAK1/MAP2K2/CSNK2A1/EML4/PIK3CA/PPP3R1/MAPK13/IKBKB/TRAF6/RASGRP1/IFNG/MAP2K6/AKT1/PLCG1/NFATC3/RELA/MAP2K1/NFKBIE/CD3G/CD3E/MAP2K3/PIK3R1/CD28/PPP3CB/NFATC1/CHUK/NFATC2/RAF1/CSNK2A2	7.38825685369538
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	89/1948	227/9376	1.88709079231834	CASP3/CASP8/CXCR4/PRKACB/CYCS/GNG2/RAC2/CGAS/ARHGEF1/TAP1/KRAS/STAT3/CTNNB1/B2M/TRAF5/PPP3CA/PTGER4/IL10RA/MAPK1/CALR/GNAI3/NFKB1/MDM2/SOS2/PPP3CC/RPS6KB1/PTGER2/HLA-F/PIK3CD/PRKCA/HLA-B/GNA13/JAK1/TBK1/TAP2/MAP2K2/FASLG/CCR5/ATF2/SOS1/PIK3CA/PPP3R1/IRF3/MAPK13/CALM1/IKBKB/ROCK1/ATF6B/MAP2K6/CREB1/ITPR1/PDIA3/AKT1/GNG5/FAS/GNB5/NFATC3/RHEB/RELA/HLA-A/MAP2K1/TSC2/IL10RB/PLCB2/BID/BAK1/ADCY7/RB1/ELK1/PIK3R1/ITPR3/CCL5/PPP3CB/CALM2/NFATC1/PLCB1/E2F3/CHUK/GNGT2/NFATC2/CRKL/ARHGEF12/TSC1/RAF1/ADCY3/GNAS/CASP9/PTGS2/ITPR2	6.9284861505549
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	95/1948	250/9376	1.82899383983573	HSPA1A/HSPA1B/HSPA8/ARAP2/CXCR4/WIPF1/HSPA6/SMAP2/ARF6/CDC42/EPS15/CHMP5/CBLB/PDCD6IP/MDM2/IL2RB/ARFGAP2/ARFGAP3/ARPC5L/STAM/CAPZA1/ACAP1/HLA-F/CHMP7/VPS26A/ACTR2/VPS36/ACTR3/SH3GLB1/HLA-B/RAB8A/SNX1/SH3KBP1/TGFBR2/SNX3/VPS37B/AGAP2/ARFGEF1/ITCH/ARF4/IST1/BIN1/ARRB2/CAPZA2/CYTH4/ARPC1B/SMAP1/VPS45/CCR5/EHD1/RAB11FIP4/DNM2/RAB11FIP1/RAB11FIP2/CBL/ACAP2/TRAF6/CYTH1/VPS4A/RUFY1/IQSEC3/RAB5A/ARF1/TSG101/CHMP4A/STAMBP/SNX6/EPS15L1/GRK2/WASHC1/RAB22A/WIPF3/PSD4/VPS29/SNX5/GIT2/HLA-A/ASAP1/GRK6/ARPC3/PIP5K1A/ZFYVE16/CYTH2/CHMP2B/LDLRAP1/WASHC2C/IL2RG/ZFYVE27/SMURF2/RBSN/WIPF2/PARD6B/ACTR3C/WWP1/KIF5C	6.8033880432803
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	61/1948	137/9376	2.14307768401805	CASP3/CASP8/PMAIP1/ATM/BCL2L11/CYCS/SPTAN1/KRAS/TRAF1/ERN1/MCL1/CFLAR/MAPK1/PRF1/NFKB1/LMNB1/BCL2/CTSC/BIRC2/DDIT3/PIK3CD/TUBA1A/CAPN2/TUBA4A/MAP2K2/TNFRSF10A/FASLG/GADD45A/CASP10/PIK3CA/PARP1/EIF2S1/IKBKB/GZMB/HTRA2/PARP4/CASP2/MAPK8/CASP7/APAF1/BBC3/ITPR1/AKT1/FAS/RELA/MAP2K1/BIRC3/BID/BAK1/AIFM1/PIK3R1/ITPR3/CHUK/EIF2AK3/CASP6/RAF1/MAP3K14/CASP9/ITPR2/PDPK1/MAPK9	6.90188491156203
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	61/1948	138/9376	2.12754813558313	WIPF1/RAC2/LCK/ITGA4/ARHGEF1/ARF6/WAS/CDC42/MAPK1/CASP1/NFKB1/ARPC5L/ACTR2/LCP2/PIK3CD/VAV3/ACTR3/ZAP70/LAT/VAV1/TBK1/PYCARD/PKN2/MAP2K2/ARPC1B/PIK3CA/IRF3/MAPK13/IKBKB/TRAF6/ROCK1/MAPK8/MAP2K6/CD8B/AKT1/CD8A/PLCG1/NFATC3/WIPF3/RELA/GIT2/MAP2K1/ARPC3/PIP5K1A/MAP2K3/IRAK4/PIK3R1/NFATC1/SKAP2/MAP3K7/CHUK/RPS6KA3/NFATC2/CRKL/ARHGEF12/ARHGEF7/WIPF2/RPS6KA1/ACTR3C/TAB1/MAPK9	6.83328952967457
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	41/1948	78/9376	2.52998473121676	HSPD1/CNOT2/BTG1/DDX6/HSPA9/LSM8/BTG3/PFKP/PNPT1/XRN1/TOB1/PAN3/CNOT4/CNOT9/BTG2/CNOT7/DCP1A/EXOSC6/C1D/EXOSC3/DIS3/LSM1/XRN2/EXOSC1/CNOT6L/EXOSC9/DCP2/PATL1/LSM2/EXOSC8/ZCCHC7/LSM6/CNOT1/CNOT10/LSM5/EXOSC2/PARN/TENT4B/DCPS/CNOT6/MPHOSPH6	6.94838372002772
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	86/1948	224/9376	1.84790261073629	ATM/PRKACB/BUB3/LCK/CCND3/ELK4/KRAS/B2M/ETS1/PPP3CA/CCND2/XPO1/MAPK1/CALR/JAK3/NFKB1/TBPL1/PTEN/PTTG1/PPP3CC/IL2RB/EP300/HLA-F/ZFP36/PIK3CD/VDAC3/ATR/SLC25A5/HLA-B/ANAPC5/VDAC2/TGFBR2/RAN/JAK1/KAT2B/MAD1L1/CDKN2C/MAP2K2/ATF2/PIK3CA/PPP3R1/CRTC3/TCF3/ANAPC16/TRRAP/IKBKB/ANAPC10/ANAPC4/GPS2/ANAPC1/SMAD4/MAPK8/CDC26/NFKB2/ATF6B/CREB1/AKT1/POLB/NFATC3/RELA/TGFB1/HLA-A/RANBP1/MAP2K1/CD3G/CD3E/KAT2A/ADCY7/RB1/ELK1/MAP3K1/STAT5B/PIK3R1/PPP3CB/NFATC1/IL2RG/E2F3/CHUK/CDKN2B/NFATC2/RANBP3/ADCY3/MAP3K14/MAD2L1/DLG1/MAPK9	6.57742860724408
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	68/1948	163/9376	2.00793640795656	CASP3/CASP8/IRF7/DDX3X/CYCS/STAT4/KRAS/STAT3/MAPK1/STAT1/JAK3/NFKB1/SOS2/BCL2/EP300/STAT2/PIK3CD/VDAC3/PRKCA/TGFBR2/JAK1/TBK1/YWHAZ/MAP2K2/FASLG/ATF2/CASP10/SOS1/PIK3CA/IRF3/TRAF3/MAPK13/IKBKB/TRAF6/IFIH1/SMAD4/MAPK8/APAF1/ATF6B/MAP2K6/CREB1/AKT1/FAS/NFATC3/RELA/TGFB1/IKBKE/MAP2K1/YWHAB/BID/BRAF/MAP2K3/IRAK4/RB1/ELK1/MAP3K1/STAT5B/PIK3R1/NFATC1/MAP3K7/E2F3/CHUK/NFATC2/TYK2/RAF1/CASP9/TAB1/MAPK9	6.64768705206422
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	75/1948	187/9376	1.93040441862763	CASP8/IRF7/OAS2/TANK/OAS1/TXNIP/HSP90AB1/HSP90AA1/IRF9/IFI16/MAP1LC3B/TRAF5/TRPM7/CASP4/CARD16/GBP5/MAPK1/STAT1/GBP4/SUGT1/CASP1/NFKB1/PSTPIP1/CARD8/RBCK1/DNM1L/BCL2/BIRC2/STAT2/OAS3/VDAC3/AIM2/ERBIN/ATG12/GBP2/VDAC2/ATG16L1/JAK1/TBK1/PYCARD/PKN2/NLRP1/TP53BP1/GPSM3/ATG5/IRF3/TRAF3/MAPK13/GBP1/IKBKB/TRAF6/GABARAPL2/MAPK8/TRPV2/GSDMD/GBP3/ITPR1/NAMPT/RELA/IKBKE/GABARAPL1/PLCB2/BIRC3/IRAK4/TNFAIP3/ITPR3/CCL5/PLCB1/MAP3K7/CHUK/TYK2/MCU/ITPR2/TAB1/MAPK9	6.58116241363448
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	49/1948	103/9376	2.28974701461295	DDX39B/PAPOLA/PPP2R5C/SMG1/PPP1CB/PNN/PPP2R5A/EIF4A3/CPSF6/PABPN1/RNMT/MAGOH/HBS1L/WDR33/GSPT1/ACIN1/RNPS1/PPP1CC/MSI2/PPP2R2A/FIP1L1/ETF1/PPP2CA/NXT1/PPP2R3C/NCBP2/RBM8A/PAPOLG/FUS/CLP1/RNGTT/PPP2R2D/NCBP1/CSTF1/SAP18/PELO/PPP2R2B/ALYREF/NXF1/WDR82/UPF1/CSTF2T/SRRM1/CASC3/MAGOHB/SMG6/NUDT21/SMG7/CSTF3	6.73995785162647
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	77/1948	196/9376	1.89087709005573	CASP3/CLEC2B/CASP8/IRF7/EIF2AK2/CYCS/GNG2/IRF9/IFNGR1/KRAS/STAT3/CTNNB1/MAP1LC3B/PLCG2/PPP3CA/HIF1A/LEF1/MAPK1/STAT1/NFKB1/PPP3CC/EP300/HLA-F/ZFP36/STAT2/UBB/PIK3CD/PREX1/HLA-B/JAK1/TBK1/ATG3/MAP2K2/CCR5/PIK3CA/PPP3R1/PIK3CG/IRF3/TRAF3/MAPK13/CALM1/TCF7/IKBKB/MAPK8/MAP2K6/CREB1/ITPR1/AKT1/GNG5/PIK3C3/PLCG1/FAS/GNB5/NFATC3/RELA/HLA-A/IKBKE/MAP2K1/BID/BAK1/RB1/PIK3R1/PIK3R6/ITPR3/PPP3CB/CALM2/NFATC1/E2F3/CHUK/GNGT2/NFATC2/TYK2/RAF1/CASP9/PTGS2/ITPR2/MAPK9	6.45458987976715
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	41/1948	83/9376	2.37757601246877	OGT/EZH2/JARID2/UBE2D3/EED/KDM2A/MTF2/PHC3/CBX4/RBBP4/PHF1/RYBP/EP300/MBD5/PCGF5/ASXL1/MAX/SUZ12/UBE2D2/SKP1/AEBP2/RBBP7/ASXL2/RNF2/L3MBTL2/YAF2/TFDP1/USP7/EZH1/MGA/FBRS/HDAC1/KDM2B/AUTS2/PHF19/LCOR/HCFC1/FOXK1/CBX6/USP45/BCOR	6.45536519610242
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	81/1948	216/9376	1.80492813141684	HSPA1A/CASP3/CASP8/HSPA1B/HSPD1/HSPA8/IRF7/HSPA5/TANK/HSPA6/CYCS/HSP90AB1/HSP90AA1/ARHGEF1/KRAS/STAT3/PPP3CA/ERN1/CDC42/MAPK1/HSPA4/CASP1/NFKB1/PPP3CC/RAP1A/RAP1B/BCL2/DDIT3/XBP1/PIK3CD/VAV3/ABCG1/PRKCA/VAV1/TBK1/PYCARD/TNFRSF10A/FASLG/CAMK2D/ERO1A/PIK3CA/PPP3R1/IRF3/TRAF3/MAPK13/CALM1/EIF2S1/NCF4/IKBKB/NFE2L2/TRAF6/MAPK8/CASP7/APAF1/MAP2K6/ITPR1/AKT1/PLCG1/FAS/NFATC3/RELA/IKBKE/PLCB2/BID/MAP2K3/IRAK4/PIK3R1/CCL5/PPP3CB/CALM2/NFATC1/PLCB1/MAP3K7/CHUK/NFATC2/EIF2AK3/CASP6/CASP9/PDPK1/TAB1/MAPK9	6.12887002671832
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	49/1948	109/9376	2.16370589454251	HSP90AB1/LCK/HSP90AA1/IFNGR1/CD247/STAT3/PPP3CA/HIF1A/MAPK1/STAT1/JAK3/NFKB1/PPP3CC/IL2RB/IL27RA/ZAP70/IRF4/TGFBR2/PRKCQ/LAT/JAK1/TBX21/AHR/PPP3R1/GATA3/MAPK13/IKBKB/SMAD4/MAPK8/IFNG/PLCG1/IL23A/IL4R/NFATC3/RELA/TGFB1/NFKBIE/CD3G/CD3E/STAT5B/PPP3CB/NFATC1/IL21R/IL2RG/CHUK/NFATC2/TYK2/RARA/MAPK9	6.25793529776674
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	67/1948	169/9376	1.90816859652747	TANK/PRKACB/CALCOCO2/VMP1/KRAS/MAP1LC3B/HIF1A/ERN1/CFLAR/MAPK1/NRBF2/BIRC6/PTEN/RPS6KB1/BCL2/UBB/PIK3CD/PPP2CA/SH3GLB1/RAB8A/OPTN/ATG12/SUPT20H/ATG16L1/PRKCQ/TBK1/TAX1BP1/NBR1/ATG3/MAP2K2/PIK3CA/STX17/ATG5/IGBP1/PRKAA1/EIF2S1/TRAF6/GABARAPL2/MAPK8/HMGB1/ITPR1/AKT1/PIK3C3/RHEB/RUBCN/MAP2K1/TSC2/GABARAPL1/EPG5/PIK3R1/RAB33B/PLEKHM1/RAB39B/MAP3K7/RRAS2/RRAGB/ATG2A/EIF2AK3/STK11/TSC1/DDIT4/RAF1/DAPK2/C9orf72/PDPK1/WIPI2/MAPK9	6.10091435055411
Genetic Information Processing	Transcription	hsa03040	Spliceosome	88/1948	243/9376	1.7430307332201	HSPA1A/SRSF5/BCAS2/TRA2A/HSPA1B/DDX5/HSPA8/SRSF7/SRSF6/DDX39B/SRSF2/HSPA6/HNRNPA3/SF3B1/HNRNPU/SRSF3/WBP11/EIF4A3/SRSF10/LSM8/THOC3/TRA2B/SNRPA1/SRSF9/MAGOH/PHF5A/PRPF18/ACIN1/DHX15/RBMXL1/SF3B6/U2SURP/HNRNPK/PRPF38A/CCDC12/SF1/HNRNPC/SRSF4/SNRNP27/SNRPB2/SRSF1/AQR/HNRNPA1/NCBP2/PLRG1/PPIH/SNRNP70/RBM8A/SF3B2/PRPF8/RBM22/SF3A3/BUD31/FUS/SRSF8/SNRNP40/SNW1/CDC40/SYF2/CWC15/PRPF3/NCBP1/SMNDC1/CRNKL1/LSM2/SF3B4/SF3A1/DHX8/SF3A2/THOC1/CDC5L/PRPF40A/RBM17/ALYREF/LSM6/THOC7/BUD13/LSM5/SF3B3/CASC3/SF3B5/SNRPB/GPKOW/MAGOHB/CHERP/USP39/THOC5/U2AF1L4	6.00962471504156
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	89/1948	248/9376	1.72729681393654	CASP3/CASP8/PTPRC/DYNLT1/CYCS/HSP90AB1/HSP90AA1/CTNNB1/ARF6/CDC42/CASP4/LEF1/MAPK1/CASP1/KPNA4/NFKB1/RHOH/ARPC5L/BCL2/GCC2/MYL12A/BIRC2/RAB9A/ACTR2/PIK3CD/NCKAP1L/ACTR3/TUBA1A/DYNLT3/M6PR/PYCARD/TUBA4A/CYTH4/SKP1/MAP2K2/ARPC1B/TNFRSF10A/EXOC5/ACBD3/PIK3CA/MLKL/DNM2/PIK3CG/DCTN4/EXOC2/MAPK13/MYL12B/TCF7/ABI1/IKBKB/TRAF6/CYFIP2/CYTH1/DYNLL2/RAB5A/ARF1/MAPK8/CASP7/MAP2K6/GSDMD/AKT1/PIK3C3/KPNA1/RELA/TUBB2A/MAP2K1/DCTN6/ARPC3/BIRC3/BAK1/MAP2K3/IRAK4/ACTR10/STX10/PLEKHM1/KLC1/CYTH2/MAP3K7/CHUK/RAF1/DYNLL1/EXOC4/FBXO22/ACTR3C/EXOC7/KIF5C/TAB1/MAPK9/SNX9	5.94420634167222
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	47/1948	105/9376	2.15445389654835	CASP8/IRF1/MALT1/IRF9/KRAS/CYLD/PLCG2/PPP3CA/MAPK1/STAT1/CASP1/NFKB1/CBLB/MDM2/BCL10/PPP3CC/STAT2/PIK3CD/PYCARD/PLK3/PIK3CA/PPP3R1/MAPK13/CALM1/IKBKB/MAPK8/NFKB2/ITPR1/AKT1/IL23A/NFATC3/RELA/IKBKE/PIK3R1/ITPR3/PPP3CB/CALM2/NFATC1/RRAS2/CHUK/NFATC2/ARHGEF12/RAF1/MAP3K14/PTGS2/ITPR2/MAPK9	6.09189094105389
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	67/1948	174/9376	1.85333616559277	HSPH1/HSPA1A/HSPA1B/HSPA8/HERPUD1/HSPA5/HSPA6/DNAJB1/HSP90AB1/DNAJA1/HSP90AA1/UBE2D3/ERO1B/DNAJA2/ERN1/DNAJB11/CALR/NGLY1/DERL1/BCL2/UBQLN1/DDIT3/XBP1/PPP1R15A/SAR1B/UFD1/SAR1A/STT3B/CAPN2/MBTPS1/UBE2G1/UBE2D2/SKP1/UBE2J1/ERO1A/MAN1A1/EIF2S1/NFE2L2/SEC23A/SEC61B/UBXN1/OSTC/MAPK8/ATF6B/MOGS/PDIA3/TRAM1/CUL1/RAD23B/MAGT1/DDOST/EDEM1/SEC24B/UBXN2A/BAK1/DNAJB2/SEC24A/DAD1/YOD1/DNAJC10/EIF2AK3/FBXO6/SEC23B/UGGT1/RNF5/DERL2/MAPK9	5.81832302044436
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	42/1948	93/9376	2.17367688944823	LCK/STAT4/IFNGR1/CD247/PPP3CA/MAPK1/STAT1/JAK3/NFKB1/PPP3CC/IL2RB/ZAP70/PRKCQ/LAT/JAK1/TBX21/PPP3R1/MAML2/GATA3/MAPK13/IKBKB/MAPK8/IFNG/PLCG1/IL4R/NFATC3/RUNX3/RELA/IL12RB2/NFKBIE/CD3G/CD3E/STAT5B/PPP3CB/NFATC1/IL2RG/CHUK/NFATC2/TYK2/DLL1/MAML3/MAPK9	5.82492072403393
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	61/1948	156/9376	1.88206181224662	CASP3/CASP8/MX1/IRF7/OAS2/EIF2AK2/OAS1/RSAD2/CYCS/IRF9/KRAS/STAT3/CTNNB1/CFLAR/MAPK1/STAT1/NFKB1/SOS2/PPP2R2A/STAT2/OAS3/PIK3CD/MX2/PPP2CA/JAK1/TBK1/YWHAZ/MAP2K2/FASLG/IFIT1/SOS1/PIK3CA/IRF3/TRAF3/PPP2R2D/EIF2S1/IKBKB/TRAF6/APAF1/IFNG/PPP2R2B/AKT1/OCLN/FAS/RELA/IKBKE/MAP2K1/YWHAB/BID/BAK1/BRAF/PIAS1/RB1/PIK3R1/E2F3/CHUK/EIF3E/TYK2/SOCS3/RAF1/CASP9	5.68905360398168
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	54/1948	133/9376	1.9542079016844	KLRD1/KLRC1/CASP3/KLRC2/RAC2/SH2D1A/LCK/IFNGR1/CD247/KRAS/PLCG2/PPP3CA/MAPK1/LAT2/PRF1/KLRC3/SOS2/PPP3CC/KIR2DL4/CD48/LCP2/PIK3CD/VAV3/PRKCA/SH2D1B/HLA-B/ZAP70/LAT/VAV1/MAP2K2/TNFRSF10A/FASLG/ULBP2/NCR1/SOS1/PIK3CA/PPP3R1/GZMB/HCST/IFNG/PLCG1/FAS/KLRK1/HLA-A/MAP2K1/BID/BRAF/PIK3R1/CD244/PPP3CB/NFATC1/NFATC2/RAF1/FYN	5.67553125260739
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	61/1948	158/9376	1.85823824500299	CCNH/CDC14A/ATM/CDKN1B/PPP2R5C/BUB3/CCND3/DBF4/PPP2R5A/CCND2/MDM2/PTTG1/EP300/STAG2/SMC3/PPP2CA/MCM3/ATR/RBL2/ANAPC5/ESCO1/PDS5B/RAD21/ORC4/WAPL/MAD1L1/YWHAZ/CDKN2C/SKP1/GADD45A/RBL1/PRKDC/NDC80/ATRX/PDS5A/ANAPC16/CDKN2D/ORC2/TFDP2/ANAPC10/ANAPC4/STAG1/TFDP1/ANAPC1/SMAD4/CDC26/NIPBL/CUL1/TGFB1/HDAC1/DDX11/YWHAB/BUB1/MAD2L1BP/RB1/E2F4/E2F3/CDKN2B/ORC3/HDAC8/MAD2L1	5.57137283442912
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	65/1948	173/9376	1.80840583494558	CASP3/CASP8/MX1/ADAR/IRF7/OAS2/EIF2AK2/DNAJB1/OAS1/RSAD2/CYCS/CALCOCO2/NUP98/IRF9/CCND3/IFNGR1/PABPN1/XPO1/MAPK1/STAT1/CASP1/NFKB1/EP300/STAT2/OAS3/PIK3CD/MX2/KPNA2/PRKCA/NXT1/SLC25A5/JAK1/HNRNPUL1/TBK1/PYCARD/MAP2K2/TNFRSF10A/FASLG/PIK3CA/IRF3/TRAF3/EIF2S1/IKBKB/KPNA5/IFIH1/APAF1/IFNG/NXF1/AKT1/FAS/KPNA1/RELA/IKBKE/MAP2K1/BID/BAK1/IRAK4/PIK3R1/CCL5/CHUK/TYK2/SOCS3/RAF1/CASP9/TRIM25	5.49581299963261
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	49/1948	119/9376	1.98188186979104	CASP3/CASP8/IRF1/TRAF1/CYLD/TRAF5/CFLAR/MAPK1/IL18R1/NFKB1/DNM1L/BIRC2/PIK3CD/MAP3K8/ITCH/ATF2/CASP10/PIK3CA/MLKL/TRAF3/MAPK13/IKBKB/MAPK8/CASP7/ATF6B/MAP2K6/CREB1/AKT1/ADAM17/FAS/RELA/MAP2K1/RPS6KA5/BIRC3/MAP2K3/TNFAIP3/PIK3R1/CSF1/CCL5/CEBPB/MAP3K7/CHUK/RHBDF2/SOCS3/MAP3K14/FRMD8/PTGS2/TAB1/MAPK9	5.52003405091596
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	39/1948	87/9376	2.15761523755576	CASP3/PMAIP1/BCL2L11/CYCS/RAC2/KRAS/CTNNB1/LEF1/MAPK1/SOS2/RPS6KB1/BCL2/PIK3CD/TGFBR2/MAP2K2/GADD45A/SOS1/PIK3CA/TCF7/AREG/SMAD4/MAPK8/BBC3/MLH1/RALGDS/AKT1/TGFB1/MAP2K1/BAK1/BRAF/PIK3R1/APC/MSH2/AXIN1/RAF1/CASP9/MSH3/RALB/MAPK9	5.55499339029016
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	55/1948	142/9376	1.86424501836481	SOCS1/JUND/LCK/IRF9/IFNGR1/CYLD/PLCG2/PPP3CA/MAPK1/STAT1/NFKB1/PPP3CC/STAT2/LCP2/PIK3CD/CAMK4/TGFBR2/JAK1/TEC1/PIK3CA/PPP3R1/MAPK13/NCF4/IKBKB/TRAF6/ATP2A2/MAPK8/NFKB2/IFNG/MAP2K6/CREB1/ITPR1/AKT1/RELA/TGFB1/MAP2K1/SIRPG/TNFSF11/FOSB/PIK3R1/CSF1/ITPR3/PPP3CB/NFATC1/MAP3K7/CHUK/NFATC2/TYK2/SOCS3/MAP3K14/FYN/TMEM64/ITPR2/TAB1/MAPK9	5.31410692886919
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	50/1948	125/9376	1.92525667351129	PPP2R5C/RAC2/KRAS/PPP2R5A/ORMDL1/MAPK1/GNAI3/NFKB1/PTEN/PPP2R2A/BCL2/DEGS1/ORMDL3/PIK3CD/PPP2CA/PRKCA/S1PR4/PPP2R3C/GNA13/MAP2K2/PIK3CA/MAPK13/SPTLC2/PPP2R2D/SPHK2/NSMAF/SGMS1/ROCK1/MAPK8/CERS2/PPP2R2B/SPTLC1/CERS6/AKT1/CERS5/RELA/ABCC1/MAP2K1/PLCB2/BID/PIK3R1/SPTSSB/PLCB1/S1PR5/S1PR1/RAF1/FYN/SGPP1/PDPK1/MAPK9	5.33294444027855
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/1948	133/9376	1.84564079603526	STK4/ATM/CDKN1B/BCL2L11/KRAS/STAT3/CCND2/MAPK1/MDM2/PTEN/SOS2/SIRT1/EP300/PIK3CD/RBL2/S1PR4/ATG12/TGFBR2/AGAP2/KLF2/CAT/MAP2K2/FASLG/GADD45A/SOS1/PLK3/PIK3CA/MAPK13/CDKN2D/PRKAA1/IKBKB/GABARAPL2/SMAD4/MAPK8/USP7/AKT1/TGFB1/MAP2K1/GABARAPL1/BCL6/BRAF/PIK3R1/CHUK/CDKN2B/PLK2/STK11/S1PR1/RAF1/PRKAG2/PDPK1/MAPK9	5.02978518403146
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	46/1948	117/9376	1.89234630302392	EPC1/PHF6/BRD7/CHD3/ACTR6/DPF2/ARID1B/SMARCA2/RBBP4/SMARCE1/SMARCC2/SMARCA5/BCL7B/GATAD2A/ARID2/MBD2/UCHL5/PHF10/EPC2/DPF3/SMARCC1/RBBP7/ACTR8/TRRAP/INO80/BPTF/CDK2AP2/PBRM1/GATAD2B/ACTL6A/BCL7C/ING3/BRD8/YEATS4/CHRAC1/MEAF6/HDAC1/MORF4L2/EP400/INO80D/DMAP1/MRGBP/SS18/BICRAL/MTA2/SMARCD1	4.97380190654963
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	83/1948	253/9376	1.57901486068614	ATM/CYCS/CALCOCO2/CGAS/MALT1/TIFA/UBE2V1/UBE2D3/PPID/MAP1LC3B/PLCG2/TRAF5/ARF6/CDC42/CASP4/MAPK1/CASP1/NFKB1/GLMN/MDM2/BCL10/RPS6KB1/HCLS1/FNBP1/RBCK1/ARPC5L/BCL2/MYL12A/ACTR2/UBE2N/UBB/PIK3CD/ACTR3/DIAPH1/ATG12/ATG16L1/PRKCQ/TBK1/CAPN2/PYCARD/UBE2D2/CYTH4/SKP1/ARPC1B/PIK3CA/ATG5/IRF3/MAPK13/MYL12B/IKBKB/TRAF6/UBE2V2/CYTH1/ARF1/ROCK1/MAPK8/ITPR1/CUL1/AKT1/PIK3C3/PLCG1/RELA/ARPC3/RPS6KA5/PLCB2/CD44/PIK3R1/ITPR3/CYTH2/CCL5/PLCB1/MAP3K7/CHUK/RRAGB/CRKL/BTRC/ACTR3C/GSK3A/ITPR2/U2AF1L4/TAB1/WIPI2/MAPK9	4.78107218034119
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	70/1948	205/9376	1.64351179446086	CASP3/CASP8/GTF2B/PMAIP1/IRF7/EIF2AK2/CDKN1B/PRKACB/DDX3X/RASA2/GTF2H2/SP100/IRF9/CCND3/KRAS/STAT3/TRAF1/TRAF5/CCND2/CDC42/MAPK1/JAK3/NFKB1/TBPL1/MDM2/EP300/HLA-F/HNRNPK/PIK3CD/VDAC3/RBL2/HLA-B/JAK1/UBE3A/KAT2B/GTF2A2/MAD1L1/YWHAZ/GTF2H2C/CCR5/ATF2/PIK3CA/RBL1/IRF3/SNW1/TRAF3/NFKB2/ATF6B/USP7/CREB1/REL/POLB/RELA/HLA-A/HDAC1/RANBP1/YWHAB/HDAC3/BAK1/KAT2A/RB1/STAT5B/PIK3R1/GTF2H3/HDAC9/GTF2A1/CDKN2B/HDAC8/DLG1/HDAC10	4.77055889629251
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	32/1948	72/9376	2.13917408167922	CASP8/ADAR/IRF7/TANK/DDX3X/CYLD/RNF125/NFKB1/SIKE1/ATG12/ZNFX1/TBK1/CASP10/AZI2/ATG5/IRF3/TRAF3/MAPK13/IKBKB/TRAF6/IFIH1/MAPK8/OTUD5/RELA/IKBKE/MAP3K1/ISG15/MAP3K7/CHUK/DHX58/TRIM25/MAPK9	4.9689618191191
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	112/1948	368/9376	1.46486920810642	CASP3/PSMD12/HNRNPA2B1/SRSF7/PSMA6/HSPA5/TANK/CYCS/HNRNPA3/NUP98/SRSF3/MAP1LC3B/PPP3CA/PSMA2/ERN1/NUP58/CASP1/NRBF2/RANBP2/DERL1/PPP3CC/NUP153/BCL2/NDUFV2/UBQLN1/NUP54/DDIT3/PSMD6/SETX/PSMC6/XBP1/NDUFB8/SDHD/PSMA3/PSMC4/PSMD13/NXT1/RAB8A/OPTN/TUBA1A/PSMD11/NUP210/HNRNPA1/TBK1/NUP205/NDUFA5/ATP5F1C/TUBA4A/NUP50/NUP88/FUS/CAT/SDHA/ATXN2L/PSMA1/NDUFB5/ATXN2/PSMA5/CHCHD10/UQCRFS1/PPP3R1/UQCRH/DCTN4/NUP107/NDUFC2/MAPK13/UQCRC2/NCBP1/EIF2S1/NDUFB3/RAB5A/TPR/APAF1/MAP2K6/ALYREF/NXF1/SOD1/PIK3C3/TUBB2A/NDUFAB1/PSMD9/ATP5MC3/NUP160/DCTN6/COX7A2L/SPG11/BID/COX7A2/MAP2K3/PSMC2/ACTR10/KLC1/ITPR3/CHMP2B/PPP3CB/POM121C/NUP188/NDUFA7/RAB39B/NUP62/ATG2A/EIF2AK3/NUP43/MCU/NDUFA8/SEH1L/CASP9/VAPB/C9orf72/KIF5C/NDUFA9/WIPI2	4.65891372308629
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	32/1948	73/9376	2.10987032713566	APOBEC3G/MX1/CXCR4/BST2/MDFIC/CPSF6/NELFCD/XPO1/RANBP2/PDCD6IP/ELL2/NUP153/CCNT2/EP300/SAMHD1/MX2/TRIM5/PSIP1/RAN/CCNT1/APOBEC3C/KAT2B/CCR5/APOBEC3D/CDK9/AFF4/MLLT3/VPS4A/TSG101/CHMP4A/SUPT4H1/KAT2A	4.87490691093091
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	33/1948	77/9376	2.06277500733353	RAC2/KRAS/STAT3/CDC42/MAPK1/STAT1/NFKB1/RPS6KB1/ARHGEF6/PIK3CD/TGFBR2/JAK1/GADD45A/PIK3CA/IKBKB/SMAD4/MAPK8/RALGDS/AKT1/RELA/TGFB1/MAP2K1/BAK1/BRAF/RB1/PIK3R1/E2F3/CHUK/RAF1/BRCA2/CASP9/RALB/MAPK9	4.79526639071762
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	18/1948	32/9376	2.70739219712526	CASP3/CASP8/PMAIP1/BCL2L11/CYCS/BIRC6/BCL2/BIRC2/HTRA2/MAPK8/CASP7/APAF1/BBC3/BIRC3/BID/BAK1/CASP9/MAPK9	4.954342579128
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	32/1948	75/9376	2.05360711841205	CASP3/CASP8/PMAIP1/ATM/CYCS/TOP2B/MAPK1/MDM2/BCL2/BIRC2/PIK3CD/XPA/FASLG/PIK3CA/ATP7A/APAF1/BBC3/MLH1/AKT1/FAS/BIRC3/BID/BAK1/PIK3R1/ERCC1/POLH/MSH2/GSTM2/GSTM4/CASP9/MSH3/PDPK1	4.69125102815256
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	18/1948	33/9376	2.62535000933358	VTI1A/VAMP2/SEC22B/GOSR1/STX5/STX16/STX11/VAMP7/VAMP1/STX17/GOSR2/STX4/VAMP4/STX3/STX6/BET1L/USE1/STX1A	4.78966192963937
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	49/1948	138/9376	1.70901407612416	SOCS1/PRKACB/PPP1CB/KRAS/MAPK1/PRKAR1A/CBLB/SOS2/RPS6KB1/PPP1CC/MKNK2/PIK3CD/MAP2K2/SOS1/PIK3CA/EIF4E/CBL/CALM1/SOCS4/PRKAA1/ACACA/IKBKB/PHKB/RAPGEF1/MAPK8/MKNK1/AKT1/RHEB/MAP2K1/TSC2/BRAF/ELK1/PIK3R1/SREBF1/CALM2/SOCS2/CRKL/PPP1R3D/PDE3B/TSC1/PYGB/SOCS3/RAF1/PPP1R3B/EXOC7/PRKAG2/PDPK1/PPP1R3E/MAPK9	4.29684401922712
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	44/1948	120/9376	1.76481861738535	KRAS/PLCG2/CDC42/MAPK1/NFKB1/SOS2/RAP1A/RAP1B/BCL2/PIK3CD/CAMK4/MATK/ZNF274/MAP2K2/FASLG/CAMK2D/SOS1/PIK3CA/KIDINS220/MAPK13/CALM1/IKBKB/TRAF6/RAPGEF1/MAPK8/AKT1/PLCG1/RELA/MAP2K1/NFKBIE/RPS6KA5/ARHGDIB/BRAF/IRAK4/MAP3K1/PIK3R1/CALM2/PSEN1/RPS6KA3/CRKL/RPS6KA1/RAF1/PDPK1/MAPK9	4.31798936227573
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	33/1948	83/9376	1.91365874174315	CASP3/CASP8/ADAR/IRF7/POLR2K/CGAS/IFI16/POLR1D/G3BP1/CASP1/NFKB1/ZBP1/SAMHD1/POLR3GL/POLR3K/AIM2/POLR3E/TBK1/PYCARD/POLR3A/MLKL/IRF3/IKBKB/CASP7/GSDMD/POLR2H/RELA/IKBKE/POLR3F/CCL5/POLR3C/POLR3D/CHUK	4.28143404732609
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	30/1948	73/9376	1.97800343168969	STK4/KRAS/STAT3/PLCG2/MAPK1/JAK3/SOS2/PIK3CD/PRKCA/RASSF1/RASSF5/MAP2K2/GADD45A/SOS1/EML4/PIK3CA/AKT1/PLCG1/MAP2K1/BAK1/BRAF/RB1/STAT5B/PIK3R1/E2F3/FHIT/RAF1/CASP9/KIF5C/PDPK1	4.2957051571624
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	28/1948	67/9376	2.01146219620583	PRKACB/PPP1CB/KRAS/PPP3CA/MAPK1/PPP3CC/RAP1A/PPP1CC/RAP1B/EP300/CAMK4/PRKCA/MAP2K2/CAMK2D/PPP3R1/CALM1/ITPR1/MAP2K1/PLCB2/BRAF/ITPR3/PPP3CB/CALM2/PLCB1/RPS6KA3/RPS6KA1/RAF1/ITPR2	4.25480546725176
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	41/1948	112/9376	1.76195365209739	HSPA1A/CASP3/CASP8/HSPA1B/SOCS1/HSPA8/HSPA6/CYCS/IFNGR1/STAT3/IL10RA/MAPK1/STAT1/GNAI3/NFKB1/BCL2/BIRC2/JAK1/CCR5/PIK3CG/MAPK13/IKBKB/TRAF6/MAPK8/IFNG/MAP2K6/AKT1/RELA/TGFB1/IL10RB/BIRC3/MAP2K3/IRAK4/PIK3R6/MAP3K7/CHUK/TYK2/CASP9/PDPK1/TAB1/MAPK9	4.15415273461635
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	133/1948	480/9376	1.33364134154689	CASP3/CASP8/PSMD12/PSMA6/HSPA5/TANK/CYCS/KRAS/CTNNB1/CSNK1A1/PPID/MAP1LC3B/PPP3CA/PSMA2/ERN1/MAPK1/NFKB1/NRBF2/DERL1/PPP3CC/BCL2/NDUFV2/ATXN1/DDIT3/PSMD6/PSMC6/XBP1/NDUFB8/UBB/SDHD/VDAC3/PSMA3/PRKCA/PSMC4/PSMD13/SLC25A5/RAB8A/OPTN/TUBA1A/PSMD11/VDAC2/TBK1/NDUFA5/ATP5F1C/CAPN2/TUBA4A/UBE2G1/FUS/CAT/SDHA/ATXN2L/PSMA1/MAP2K2/NDUFB5/ATXN2/UBE2J1/FASLG/PSMA5/CAMK2D/CSNK2A1/UQCRFS1/PPP3R1/UQCRH/DCTN4/NDUFC2/MAPK13/CALM1/UQCRC2/EIF2S1/UBE2L6/ATP2A2/HTRA2/NDUFB3/RAB5A/MAPK8/CASP7/APAF1/MAP2K6/ITPR1/SOD1/PIK3C3/PLCG1/FAS/RELA/TUBB2A/NDUFAB1/MAP2K1/PRNP/PSMD9/ATP5MC3/HTT/DCTN6/COX7A2L/SPG11/PLCB2/BID/COX7A2/BAK1/BRAF/MAP2K3/PSMC2/ACTR10/APC/IFT57/CSF1/KLC1/ITPR3/FRAT2/CHMP2B/PPP3CB/CALM2/NDUFA7/RAB39B/PLCB1/PSEN1/ATG2A/EIF2AK3/AXIN1/RAF1/MCU/NDUFA8/STX1A/CASP9/VAPB/C9orf72/CSNK2A2/ATXN1L/PTGS2/KIF5C/ITPR2/NDUFA9/WIPI2/MAPK9	3.84279535698262
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	49/1948	144/9376	1.63780515628565	GTF2B/PSMD12/PSMA6/CYCS/PSMA2/ERN1/NRBF2/TBPL1/ATXN1/PSMD6/PSMC6/XBP1/PIK3CD/VDAC3/PSMA3/PRKCA/PSMC4/PSMD13/SLC25A5/OPA1/PSMD11/VDAC2/ATXN2L/PSMA1/ATXN2/PSMA5/PIK3CA/OMA1/ATP2A2/PUM1/MAPK8/ITPR1/AKT1/PIK3C3/ATXN10/PSMD9/PUM2/PLCB2/PSMC2/PIK3R1/ITPR3/PLCB1/ATG2A/MCU/AFG3L2/ATXN1L/ITPR2/WIPI2/MAPK9	3.94971301461691
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/1948	69/9376	1.95315894414189	RAC2/KRAS/PLCG2/MAPK1/SOS2/ALOX5AP/LCP2/PIK3CD/VAV3/PRKCA/LAT/VAV1/MAP2K2/SOS1/PIK3CA/MAPK13/INPP5D/MAPK8/MAP2K6/AKT1/PLCG1/MAP2K1/MAP2K3/PIK3R1/RAF1/FYN/PDPK1/MAPK9	4.06938877561641
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	38/1948	105/9376	1.74189889508165	ATM/LCK/MALT1/TRAF1/CYLD/PLCG2/TRAF5/CFLAR/NFKB1/BCL10/BCL2/BIRC2/CARD11/ZAP70/PRKCQ/LAT/UBE2I/GADD45A/CSNK2A1/TRAF3/PARP1/IKBKB/TRAF6/NFKB2/PLCG1/RELA/TNFSF11/BIRC3/IRAK4/TNFAIP3/EDARADD/MAP3K7/CHUK/MAP3K14/CSNK2A2/PTGS2/TRIM25/TAB1	3.91489618739962
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	25/1948	60/9376	2.00547570157426	RAC2/KRAS/PLCG2/PPP3CA/CDC42/MAPK1/PPP3CC/SH2D2A/PIK3CD/PRKCA/MAP2K2/PIK3CA/PPP3R1/MAPK13/MAPKAPK3/SPHK2/AKT1/PLCG1/MAP2K1/PIK3R1/PPP3CB/NFATC2/RAF1/CASP9/PTGS2	4.00107444506407
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	63/1948	200/9376	1.51613963039014	CASP3/CASP8/WIPF1/CYCS/ARHGEF1/ARF6/CDC42/CASP4/MAPK1/CASP1/NFKB1/HCLS1/ARPC5L/NCK1/ACTR2/NCKAP1L/ACTR3/TUBA1A/GNA13/PYCARD/TUBA4A/CYTH4/ARPC1B/TNFRSF10A/FASLG/NCL/MAPK13/ABI1/IKBKB/TRAF6/CYFIP2/CYTH1/MYO1F/ARF1/ROCK1/MAPK8/CASP7/PAK2/OCLN/FAS/WIPF3/RELA/MYO1G/TUBB2A/EZR/TMBIM6/SEC24B/ARPC3/NCK2/BAK1/IRAK4/SEC24A/CYTH2/MAP3K7/CHUK/LPAR2/ARHGEF12/WIPF2/FYN/CASP9/ACTR3C/TAB1/MAPK9	3.778328105208
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/1948	71/9376	1.89814038233508	SOCS1/IRF1/KRAS/STAT3/CCND2/MAPK1/STAT1/NFKB1/SOS2/PIK3CD/CISH/MAP2K2/SOS1/PIK3CA/MAPK13/SOCS4/MAPK8/AKT1/RELA/MAP2K1/GALT/TNFSF11/STAT5B/PIK3R1/SOCS2/SOCS3/RAF1/MAPK9	3.89008755518317
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	81/1948	275/9376	1.41768900504013	HSPA1A/CASP3/HSPA1B/STIP1/HSPA8/PSMD12/NCAM1/PSMA6/HSPA5/HSPA6/PRKACB/CYCS/RAC2/PPP3CA/PSMA2/MAPK1/PPP3CC/NDUFV2/DDIT3/PSMD6/PSMC6/NDUFB8/PIK3CD/SDHD/VDAC3/PSMA3/PSMC4/PSMD13/SLC25A5/TUBA1A/PSMD11/VDAC2/NDUFA5/ATP5F1C/TUBA4A/SDHA/PSMA1/NDUFB5/PSMA5/ATF2/CSNK2A1/PIK3CA/UQCRFS1/PPP3R1/UQCRH/NDUFC2/MAPK13/UQCRC2/EIF2S1/NCF4/NDUFB3/MAPK8/APAF1/ATF6B/CREB1/ITPR1/SOD1/TUBB2A/NDUFAB1/PRNP/PSMD9/ATP5MC3/COX7A2L/COX7A2/PSMC2/PIK3R1/KLC1/ITPR3/CCL5/PPP3CB/NDUFA7/EIF2AK3/MCU/FYN/NDUFA8/CASP9/CSNK2A2/KIF5C/ITPR2/NDUFA9/MAPK9	3.60013676990195
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	51/1948	157/9376	1.56350462339293	CASP3/CASP8/BCL2L11/CYCS/ERN1/CDC42/NFKB1/NDUFV2/DDIT3/XBP1/NDUFB8/PIK3CD/SDHD/NDUFA5/ITCH/SDHA/NDUFB5/FASLG/MLX/PIK3CA/UQCRFS1/UQCRH/NDUFC2/MAPK13/UQCRC2/PRKAA1/EIF2S1/IKBKB/NDUFB3/MAPK8/CASP7/ADIPOR2/AKT1/FAS/RELA/TGFB1/NDUFAB1/COX7A2L/BID/COX7A2/MLXIP/PIK3R1/SREBF1/NDUFA7/EIF2AK3/SOCS3/NDUFA8/GSK3A/PRKAG2/NDUFA9/MAPK9	3.64627625529059
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	87/1948	300/9376	1.39581108829569	HSPA1A/CASP3/HSPA1B/HSPA8/DUSP10/JUND/STK4/HSPA6/PRKACB/RASA2/RAC2/ELK4/KRAS/PTPN7/PPP3CA/CDC42/MAPK1/NFKB1/SOS2/PPP3CC/RAP1A/RAP1B/DDIT3/DUSP2/MKNK2/PRKCA/MAP3K12/DUSP1/MAP3K8/DUSP5/TGFBR2/MAX/MAP4K1/ARRB2/PPM1B/MAP2K2/FASLG/GADD45A/ATF2/SOS1/PPP3R1/MAPK13/DUSP4/IKBKB/MAPKAPK3/TRAF6/AREG/RASGRP1/MAP4K4/MAPK8/PAK2/NFKB2/MKNK1/MAP2K6/AKT1/KIT/MAPKAPK5/FAS/MAP3K2/NFATC3/RELA/TGFB1/MAP2K1/NF1/DUSP8/RPS6KA5/BRAF/MAP2K3/PPM1A/IRAK4/ELK1/MAP3K1/CSF1/STMN1/PPP3CB/NFATC1/MAP3K7/RRAS2/CHUK/RPS6KA3/CRKL/LAMTOR3/RPS6KA1/RAF1/MAP3K14/TAB1/MAPK9	3.56816975033292
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/1948	59/9376	1.95788814255386	KRAS/CTNNB1/LEF1/MAPK1/PTEN/SOS2/PIK3CD/MAP2K2/GADD45A/SOS1/PIK3CA/TCF7/MLH1/AKT1/MAP2K1/BAK1/BRAF/ELK1/PIK3R1/APC/AXIN1/RAF1/CASP9/PDPK1	3.77960941624677
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/1948	56/9376	1.97682604869463	HSPA1A/CASP3/CASP8/HSPA1B/HSPD1/HSPA8/HSPA6/CYCS/CLK4/CASP1/NFKB1/HBS1L/SEC22B/SAR1B/SAR1A/CLK1/PYCARD/ARF1/CASP7/APAF1/NFKB2/RELA/CASP9	3.75445978235227
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	25/1948	63/9376	1.90997685864216	EZH2/NSD1/PRDM2/EHMT1/DLD/SETD2/KMT2E/KMT2B/KMT5B/ASH1L/GCDH/EZH1/KMT2A/PHYKPL/NSD2/SMYD3/KMT5A/NSD3/ALDH9A1/EHMT2/HADH/ACAT2/DLST/ALDH3A2/SETDB1	3.71107719436248
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	29/1948	77/9376	1.81274167311128	CDKN1B/KRAS/MAPK1/NFKB1/MDM2/SOS2/PIK3CD/TGFBR2/MAP2K2/GADD45A/SOS1/PIK3CA/CBL/IKBKB/SMAD4/AKT1/RELA/TGFB1/HDAC1/MAP2K1/BAK1/BRAF/RB1/STAT5B/PIK3R1/E2F3/CHUK/CRKL/RAF1	3.66710997390161
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	16/1948	34/9376	2.26500785118976	POLR2K/POLR2B/POLR1D/CRCP/POLR2C/POLR3GL/POLR3K/POLR3E/POLR3A/POLR2M/POLR2J/POLR2D/POLR2H/POLR3F/POLR3C/POLR3D	3.7840504240507
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/1948	122/9376	1.6175312215976	PRKACB/KRAS/CTNNB1/PLCG2/HIF1A/MED4/MAPK1/STAT1/PFKP/MDM2/EP300/MED13/SIN3A/PIK3CD/NCOA3/PRKCA/NCOR1/NCOA1/KAT2B/MAP2K2/MED17/PIK3CA/ATP1A1/ATP2A2/AKT1/PLCG1/RHEB/HDAC1/MAP2K1/TSC2/HDAC3/PLCB2/KAT2A/PIK3R1/MED1/PLCB1/MED30/MED24/RAF1/CASP9/PDPK1	3.51575217865
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	41/1948	122/9376	1.6175312215976	SOCS1/PRKACB/KRAS/STAT3/PLCG2/MAPK1/STAT1/GNAI3/SOS2/EP300/PIK3CD/PRKCA/MAP2K2/ATF2/SOS1/PIK3CA/MAPK13/MAPK8/ATF6B/MAP2K6/CREB1/ITPR1/AKT1/PLCG1/MAP2K1/PLCB2/MAP2K3/ADCY7/MAP3K1/STAT5B/PIK3R1/ITPR3/PLCB1/SOCS2/CRKL/SOCS3/RAF1/ADCY3/GNAS/ITPR2/MAPK9	3.51575217865
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	19/1948	44/9376	2.07840209072242	GTF2B/CCNH/GTF2H2/TAF7/TBPL1/TAF15/MNAT1/TAF9/GTF2A2/GTF2H2C/TAF12/TAF11/TAF5/GTF2F2/GTF2H3/TAF13/GTF2A1/TAF8/TAF4B	3.67167186203031
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	19/1948	44/9376	2.07840209072242	RFC1/TDG/MBD4/RFC4/PARG/FEN1/RFC2/TDP1/PARP1/OGG1/PARP4/HMGB1/POLB/MUTYH/POLE/POLG/LIG1/POLG2/POLD4	3.67167186203031
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	26/1948	68/9376	1.84031887909168	PIM2/PIM1/KRAS/STAT3/LEF1/MAPK1/NFKB1/SOS2/RPS6KB1/PIK3CD/MAP2K2/SOS1/PIK3CA/TCF7/IKBKB/AKT1/KIT/RELA/MAP2K1/BRAF/STAT5B/PIK3R1/CHUK/PPARD/RAF1/RARA	3.56134917726493
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	34/1948	98/9376	1.66986548212714	SACM1L/PLCG2/PIP4K2A/DGKZ/DGKD/IMPA1/PTEN/DGKA/MTM1/IP6K1/PIK3CD/PRKCA/PIK3CA/INPP4A/CALM1/INPP5D/IP6K2/DGKE/PPIP5K2/MTMR6/ITPR1/PIK3C3/PLCG1/MTMR1/PLCB2/PIP5K1A/PIK3R1/ITPR3/CALM2/PLCB1/SYNJ2/SYNJ1/ITPR2/INPP4B	3.41363922376181
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	34/1948	98/9376	1.66986548212714	PTPRC/RAC2/PLCG2/ARF6/WAS/CDC42/MAPK1/RPS6KB1/ARPC5L/ACTR2/PIK3CD/VAV3/PRKCA/ACTR3/LAT/VASP/VAV1/MARCKSL1/BIN1/ARPC1B/PIK3CA/DNM2/INPP5D/SPHK2/AKT1/PLCG1/MAP2K1/ASAP1/ARPC3/PIP5K1A/PIK3R1/CRKL/RAF1/ACTR3C	3.41363922376181
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	93/1948	333/9376	1.34421074051464	CASP3/CASP8/MX1/OASL/ATM/EIF2AK2/CDKN1B/PRKACB/PPP2R5C/IRF1/ITGA4/IRF9/CCND3/KRAS/CTNNB1/PPP2R5A/CSNK1A1/CCND2/CDC42/PTGER4/MAPK1/STAT1/NFKB1/TBPL1/MDM2/PTEN/SOS2/RPS6KB1/PPP2R2A/ATP6V0E2/EP300/HLA-F/STAT2/PIK3CD/MX2/PPP2CA/ATR/RBL2/HLA-B/PPP2R3C/JAK1/ATP6V1H/TBK1/UBE3A/MAP2K2/PATJ/ATP6V1G1/FASLG/SOS1/PIK3CA/MAML2/RBL1/IRF3/TRAF3/PPP2R2D/TCF7/IKBKB/LLGL2/DLG3/LFNG/ITGB7/PPP2R2B/CREB1/MFNG/AKT1/FAS/TCIRG1/RHEB/RELA/HLA-A/IKBKE/HDAC1/MAP2K1/TSC2/BAK1/RB1/PIK3R1/APC/ISG15/PSEN1/CHUK/ATP6V0A2/HES6/AXIN1/TYK2/TSC1/COL9A2/PARD6B/RAF1/GNAS/MAML3/DLG1/PTGS2	3.27517443903735
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	32/1948	91/9376	1.69253333935059	RAC2/MALT1/KRAS/PLCG2/PPP3CA/MAPK1/NFKB1/BCL10/SOS2/PPP3CC/CARD11/PIK3CD/VAV3/VAV1/MAP2K2/SOS1/PIK3CA/PPP3R1/INPP5D/IKBKB/AKT1/NFATC3/RELA/MAP2K1/NFKBIE/PIK3R1/PPP3CB/DAPP1/NFATC1/CHUK/NFATC2/RAF1	3.39949647149741
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	26/1948	70/9376	1.78773833968906	KRAS/ETS1/HIF1A/CDC42/MAPK1/SOS2/RAP1A/RAP1B/VHL/EP300/PIK3CD/CUL2/ARNT/MAP2K2/SOS1/PIK3CA/RAPGEF1/PAK2/AKT1/TGFB1/MAP2K1/EGLN1/BRAF/PIK3R1/CRKL/RAF1	3.38761187200738
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/1948	63/9376	1.83357778429647	CCNH/POLR2K/GTF2H2/POLR2B/RFC1/MNAT1/POLR2C/RFC4/XPA/GTF2H2C/POLR2M/POLR2J/RFC2/POLR2D/ERCC5/POLR2H/RAD23B/GTF2H3/ERCC1/RPA3/POLE/LIG1/RPA1/POLD4	3.39950568594221
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	35/1948	103/9376	1.63553358186639	CASP8/IFNGR1/CD247/CFLAR/MAPK1/CALR/GNAI3/NFKB1/PPP2R2A/PIK3CD/PPP2CA/TGFBR2/FASLG/PIK3CA/MAPK13/PPP2R2D/IKBKB/TRAF6/MAPK8/IFNG/PPP2R2B/AKT1/FAS/RELA/TGFB1/PLCB2/CD3G/CD3E/IRAK4/PIK3R1/CCL5/PLCB1/CHUK/GNAS/MAPK9	3.32117035863669
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/1948	46/9376	1.98803678243014	PSMD12/PSMA6/PSMB9/PSMB8/PSMA2/PSMD6/PSMC6/PSMA3/PSMC4/PSMD13/PSMD11/PSMA1/PSMA5/PSME4/PSMB10/IFNG/PSME2/PSMD9/PSMC2	3.43997569124278
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	47/1948	149/9376	1.51823932307099	KRAS/PLCG2/ARF6/DGKZ/MAPK1/DGKD/SOS2/DGKA/PIK3CD/PRKCA/GNA13/CYTH4/MAP2K2/SOS1/PIK3CA/DNM2/PIK3CG/LPAR6/SPHK2/CYTH1/DGKE/ARF1/RALGDS/AKT1/KIT/PLCG1/RHEB/MAP2K1/TSC2/PLCB2/PIP5K1A/ADCY7/PIK3R1/PIK3R6/CYTH2/AGPAT5/PLCB1/RRAS2/LPAR2/TSC1/RAF1/AGPAT2/ADCY3/FYN/GNAS/AGPAT3/RALB	3.26540763774762
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	58/1948	193/9376	1.44643636092817	ITK/CXCR4/PRKACB/GNG2/RAC2/KRAS/STAT3/PLCG2/WAS/CDC42/MAPK1/STAT1/GNAI3/DOCK2/JAK3/NFKB1/SOS2/XCL1/RAP1A/RAP1B/STAT2/PIK3CD/VAV3/PREX1/VAV1/XCL2/ARRB2/CCR5/SOS1/PIK3CA/PIK3CG/IKBKB/ROCK1/GRK2/AKT1/GNG5/PLCG1/GNB5/RELA/MAP2K1/GRK6/CCR7/PLCB2/BRAF/ADCY7/STAT5B/PIK3R1/PIK3R6/CXCR6/CCL5/PLCB1/CHUK/GNGT2/CRKL/RAF1/ADCY3/GSK3A/CCR2	3.20915052893465
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1948	75/9376	1.73273100616016	CASP3/CASP8/PMAIP1/ATM/CYCS/CCND3/SESN1/CCND2/MDM4/MDM2/PTEN/BCL2/ATR/TNFRSF10A/GADD45A/CCNG1/RCHY1/SIAH1/APAF1/BBC3/FAS/TSC2/SESN2/BID/PPM1D/CASP9/COP1	3.26253024105311
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	35/1948	105/9376	1.60438056125941	USP15/CALCOCO2/KRAS/MAP1LC3B/HIF1A/ARIH1/UBB/HUWE1/OPTN/OPA1/TBK1/TAX1BP1/NBR1/CCZ1/CSNK2A1/EIF2S1/GABARAPL2/RAB5A/TBC1D15/TOMM70/MAPK8/SIAH1/CCZ1B/RELA/GABARAPL1/MTX3/RHOT1/RRAS2/MTX2/EIF2AK3/SMURF2/TOMM7/TFEB/CSNK2A2/MAPK9	3.18923126951486
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	51/1948	168/9376	1.46113229686125	CASP8/EIF2AK2/HSP90AB1/HSP90AA1/STAT4/IRF9/IFNGR1/STAT3/CYLD/PPID/TRAF5/TRPM7/CFLAR/STAT1/CASP1/JAK3/CHMP5/RBCK1/DNM1L/ZBP1/BCL2/BIRC2/CHMP7/STAT2/VDAC3/SLC25A5/VDAC2/JAK1/CAPN2/PYCARD/TNFRSF10A/FASLG/CAMK2D/MLKL/GLUD1/PARP1/VPS4A/MAPK8/HMGB1/IFNG/CHMP4A/FAS/BIRC3/BID/AIFM1/TNFAIP3/STAT5B/CHMP2B/TYK2/PYGB/MAPK9	3.08845795184878
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	35/1948	107/9376	1.57439213955363	PRKACB/PPP3CA/PFKP/PPP3CC/SIRT1/PPP4R3B/EP300/PDHA1/PPP4R3A/CAMK2D/ATF2/PPP3R1/SIK1/CALM1/PRKAA1/ACACA/PHKB/PPP4C/CREB1/ITPR1/AKT1/LDHB/PLCB2/ITPR3/PPP3CB/CALM2/PLCB1/SIK2/PDE3B/PYGB/GNAS/PDHB/PRKAG2/ITPR2/LDHA	3.06004704067092
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	31/1948	93/9376	1.60438056125941	CASP3/CKS2/CDKN1B/CYCS/TRAF1/TRAF5/NFKB1/PTEN/BCL2/BIRC2/PIK3CD/MAX/GADD45A/PIK3CA/TRAF3/IKBKB/TRAF6/APAF1/TRAF4/AKT1/RELA/BIRC3/BAK1/RB1/PIK3R1/E2F3/CHUK/CDKN2B/FHIT/CASP9/PTGS2	2.99952132323082
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	103/1948	388/9376	1.27771544698237	CASP3/CASP8/PSMD12/PSMA6/EIF2AK2/CYCS/KRAS/CTNNB1/CSNK1A1/PPID/PPP3CA/PSMA2/ERN1/MAPK1/NFKB1/NRBF2/PPP3CC/NDUFV2/DDIT3/PSMD6/NAE1/PSMC6/XBP1/NDUFB8/PIK3CD/SDHD/VDAC3/PSMA3/PSMC4/PSMD13/SLC25A5/TUBA1A/PSMD11/VDAC2/NDUFA5/ATP5F1C/CAPN2/ADAM10/TUBA4A/SDHA/PSMA1/MAP2K2/NDUFB5/PSMA5/CSNK2A1/PIK3CA/UQCRFS1/PPP3R1/UQCRH/RTN3/NDUFC2/CALM1/UQCRC2/EIF2S1/IKBKB/ATP2A2/NDUFB3/MAPK8/CASP7/APAF1/ITPR1/AKT1/ADAM17/PIK3C3/FAS/RELA/TUBB2A/NDUFAB1/MAP2K1/PSMD9/ATP5MC3/COX7A2L/PLCB2/BID/COX7A2/BRAF/PSMC2/PIK3R1/APC/CSF1/KLC1/ITPR3/FRAT2/PPP3CB/CALM2/NDUFA7/PLCB1/PSEN1/CHUK/ATG2A/EIF2AK3/AXIN1/RAF1/MCU/NDUFA8/CASP9/CSNK2A2/PTGS2/KIF5C/ITPR2/NDUFA9/WIPI2/MAPK9	2.86107033531765
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/1948	82/9376	1.64351179446086	KLRD1/KLRC1/HSPA1A/KLRC2/HSPA1B/HSPA8/HSPA5/HSPA6/HSP90AB1/HSP90AA1/TAP1/KLRC4/B2M/CALR/HSPA4/KLRC3/KIR2DL4/HLA-F/HLA-B/TAP2/IFNG/CREB1/PDIA3/CD8B/RFXAP/CD8A/PSME2/HLA-A	2.99713475790769
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	11/1948	23/9376	2.30193732702437	RFC1/RFC4/RFC2/MLH1/RPA3/LIG1/MSH2/RPA1/MSH3/PMS2/POLD4	3.20127288646399
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	29/1948	86/9376	1.62303614918103	CDKN1B/KRAS/PLCG2/MAPK1/CBLB/SOS2/RPS6KB1/NCK1/PIK3CD/PRKCA/MAP2K2/CAMK2D/SOS1/PIK3CA/CBL/AREG/MAPK8/PAK2/AKT1/PLCG1/MAP2K1/NCK2/BRAF/ELK1/STAT5B/PIK3R1/CRKL/RAF1/MAPK9	2.97234202002593
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	30/1948	90/9376	1.60438056125941	PRKACB/KRAS/SESN1/NFKB1/SIRT1/RPS6KB1/PIK3CD/EHMT1/CAMK4/CAT/ATF2/PIK3CA/ATG5/EIF4E/PRKAA1/ADIPOR2/ATF6B/CREB1/AKT1/RHEB/RELA/TSC2/SESN2/ADCY7/EHMT2/PIK3R1/STK11/TSC1/ADCY3/PRKAG2	2.95026868543505
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/1948	157/9376	1.44087680979348	CASP3/ATP8A1/ATP11B/ODC1/HIF1A/PTGER4/MAPK1/GPR132/CALR/CASP1/CD47/SIRT1/PTGER2/DUSP2/HAVCR2/DNMT3A/DUSP5/ADAM10/ARNT/MAP2K2/CAMK2D/UQCRFS1/MAPK13/RAB14/DUSP4/SPHK2/ATP2A2/RAB5A/CASP7/CREB1/SLC16A1/ADAM17/NFATC3/TGFB1/MAP2K1/DUSP8/SIRPG/ARG2/CEBPB/NFATC1/VPS8/NFATC2/CRKL/PPARD/S1PR1/ANO9/PTGS2	2.85278696273855
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	35/1948	110/9376	1.53145417211126	CDKN1B/IFNGR1/STAT3/PLCG2/HIF1A/MAPK1/NFKB1/PFKP/RPS6KB1/BCL2/VHL/EP300/MKNK2/PDHA1/PIK3CD/PRKCA/CUL2/ARNT/MAP2K2/CAMK2D/PGK1/PIK3CA/EIF4E/PFKFB3/IFNG/MKNK1/AKT1/PLCG1/LDHB/RELA/MAP2K1/EGLN1/PIK3R1/PDHB/LDHA	2.87117842800311
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	42/1948	138/9376	1.46486920810642	PRKACB/PPP2R5C/PPP1CB/PPP2R5A/PPP3CA/MAPK1/PTTG1/PPP3CC/PPP1CC/SMC3/PPP2CA/ANAPC5/MAD1L1/YWHAZ/SKP1/CAMK2D/PPP3R1/MAPK13/CALM1/ANAPC16/ANAPC10/ANAPC4/ANAPC1/CDC26/ITPR1/SLK/CUL1/STAG3/MAP2K1/YWHAB/BUB1/ADCY7/ITPR3/PPP3CB/CALM2/SPDYE16/RPS6KA3/RPS6KA1/ADCY3/BTRC/MAD2L1/ITPR2	2.81725080479945
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	47/1948	158/9376	1.43175733631378	KRAS/MAPK1/LPIN2/RICTOR/PTEN/SOS2/SLC3A2/RPS6KB1/PIK3CD/PRKCA/FNIP1/ATP6V1H/SLC7A5/LPIN1/MAP2K2/ATP6V1G1/SOS1/PIK3CA/EIF4E/EIF4B/PRKAA1/IKBKB/AKT1/RHEB/MAP2K1/TSC2/CAB39/SESN2/PRR5/BRAF/CLIP1/PIK3R1/PRR5L/CHUK/RPS6KA3/RRAGB/TBC1D7/NPRL2/STK11/TSC1/LAMTOR3/DDIT4/RPS6KA1/RAF1/SEH1L/PDPK1/TTI1	2.80281274880227
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1948	99/9376	1.55576296849397	RAC2/KRAS/HIF1A/GPCPD1/WAS/DGKZ/MAPK1/DGKD/SOS2/RPS6KB1/DGKA/PIK3CD/PRKCA/MAP2K2/SOS1/PIK3CA/DGKE/MAPK8/RALGDS/AKT1/PLCG1/RHEB/CHKB/MAP2K1/TSC2/PIP5K1A/PIK3R1/TSC1/RAF1/CHKA/PDPK1/MAPK9	2.84673860883266
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	22/1948	62/9376	1.70788898456647	EP300/ATXN1/DTX3L/CIR1/ITCH/KAT2B/TLE4/MAML2/SNW1/SPEN/LFNG/MFNG/ADAM17/HDAC1/KAT2A/PSEN1/DTX3/TLE3/DLL1/MAML3/NUMB/ATXN1L	2.86376283881347
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/1948	93/9376	1.55262634960588	PRKACB/KRAS/CDC42/MAPK1/SOS2/PRKCA/MAP2K2/CAMK2D/SOS1/MAPK13/CALM1/MAPK8/MAP2K6/ITPR1/MAP3K2/MAP2K1/PLCB2/MAP2K3/ADCY7/ELK1/MAP3K1/ITPR3/CALM2/PLCB1/RAF1/GNRH1/ADCY3/GNAS/ITPR2/MAPK9	2.74266683224872
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	52/1948	181/9376	1.38278103622358	CASP3/CASP8/HSPD1/CYCS/MALT1/IFNGR1/HSPA9/PPP3CA/IL10RA/MAPK1/STAT1/NFKB1/BCL10/PPP3CC/BCL2/EP300/JAK1/ATP6V1H/CAMK2D/CASP10/PLK3/PPP3R1/MAPK13/CALM1/TRAF6/SPHK2/RAB5A/MAPK8/APAF1/IFNG/CREB1/ITGAX/RFXAP/AKT1/PIK3C3/IL23A/TCIRG1/RELA/TGFB1/CORO1A/IL10RB/CEBPG/BID/IRAK4/PPP3CB/CALM2/CEBPB/ATP6V0A2/ARHGEF12/RAF1/CASP9/MAPK9	2.66291927581346
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	26/1948	78/9376	1.60438056125941	SACM1L/PLCG2/PIP4K2A/IMPA1/PTEN/MTM1/IP6K1/PIK3CD/PIK3CA/INPP4A/PIK3CG/INPP5D/IP6K2/PPIP5K2/MTMR6/PIK3C3/PLCG1/ALDH6A1/MTMR1/PLCB2/PIP5K1A/PLCB1/PLCH2/SYNJ2/SYNJ1/INPP4B	2.7447777529233
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	15/1948	38/9376	1.89992434885983	PTPRC/LCK/TAP1/ORAI1/JAK3/ZAP70/TAP2/ICOS/ADA/DCLRE1C/CD8B/RFXAP/CD8A/CD3E/IL2RG	2.84652520006159
Organismal Systems	Immune system	hsa04611	Platelet activation	38/1948	126/9376	1.45158241256804	PRKACB/PPP1CB/ARHGEF1/PLCG2/ORAI1/MAPK1/GNAI3/RAP1A/PPP1CC/RAP1B/MYL12A/APBB1IP/LCP2/PIK3CD/GNA13/VASP/FERMT3/STIM1/PIK3CA/PIK3CG/MAPK13/MYL12B/RASGRP1/ROCK1/ITPR1/AKT1/PPP1R12A/PLCB2/ADCY7/PIK3R1/PIK3R6/ITPR3/PLCB1/ARHGEF12/ADCY3/FYN/GNAS/ITPR2	2.61333805467837
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/1948	13/9376	2.59169167588059	XRCC5/FEN1/XRCC6/PRKDC/DCLRE1C/MRE11/LIG4	2.94081209877786
Human Diseases	Cancer: specific types	hsa05214	Glioma	25/1948	76/9376	1.58327029071652	KRAS/PLCG2/MAPK1/MDM2/PTEN/SOS2/PIK3CD/CAMK4/PRKCA/MAP2K2/GADD45A/CAMK2D/SOS1/PIK3CA/CALM1/AKT1/PLCG1/MAP2K1/BAK1/BRAF/RB1/PIK3R1/CALM2/E2F3/RAF1	2.61444400475584
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	14/1948	36/9376	1.87177732146931	PRIM1/RFC1/MCM3/RFC4/FEN1/RFC2/RNASEH2B/RPA3/POLE/LIG1/RPA1/RNASEH1/POLA2/POLD4	2.68366032860281
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	10/1948	23/9376	2.09267029729488	IDI1/HMGCS1/NUS1/HMGCR/GGPS1/FNTA/ZMPSTE24/ACAT2/DHDDS/RCE1	2.6867159608745
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	29/1948	93/9376	1.50087213795235	RAC2/CTNNB1/WAS/CDC42/LEF1/MAPK1/YES1/ACP1/RAP1A/PDCD10/RAP1B/MYL12A/EP300/TGFBR2/CCM2/CSNK2A1/MYL12B/TCF7/ROCK1/SMAD4/HEG1/IQGAP1/MAP3K7/SMURF2/PTPRJ/SSX2IP/LMO7/FYN/CSNK2A2	2.48581234126662
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	33/1948	109/9376	1.45718968407965	CASP8/IRF7/IRF9/MAPK1/STAT1/NFKB1/STAT2/PIK3CD/MAP3K8/JAK1/TBK1/MAP2K2/PIK3CA/IRF3/TRAF3/MAPK13/IKBKB/TRAF6/MAPK8/MAP2K6/AKT1/RELA/IKBKE/MAP2K1/MAP2K3/IRAK4/PIK3R1/CCL5/MAP3K7/CHUK/TYK2/TAB1/MAPK9	2.45857950466225
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	33/1948	109/9376	1.45718968407965	OGT/PPP1CB/STAT3/NFKB1/PTEN/RPS6KB1/PPP1CC/PIK3CD/PRKCQ/MLX/PIK3CA/PRKAA1/IKBKB/MAPK8/CREB1/AKT1/RELA/OGA/MLXIP/PIK3R1/SREBF1/RPS6KA3/PPP1R3D/SLC27A3/PYGB/RPS6KA1/SOCS3/PPP1R3B/PRKAG2/PDPK1/PPP1R3E/SLC27A2/MAPK9	2.45857950466225
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	17/1948	48/9376	1.70465434633812	HMGCS1/HIBCH/OXCT1/DLD/ACADM/ACAA2/AUH/ALDH6A1/HADHB/ALDH9A1/HADH/IVD/ACAT2/ACSF3/BCKDHB/ALDH3A2/MCCC1	2.50637847388696
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	71/1948	268/9376	1.27512335652334	CASP3/PSMD12/PSMA6/HSPA5/PRKACB/CYCS/PSMA2/ERN1/GNAI3/NDUFV2/DDIT3/PSMD6/PSMC6/XBP1/NDUFB8/UBB/SDHD/VDAC3/PSMA3/PSMC4/PSMD13/SLC25A5/TUBA1A/PSMD11/DUSP1/VDAC2/NDUFA5/ATP5F1C/TUBA4A/UBE2G1/SDHA/PSMA1/NDUFB5/UBE2J1/PSMA5/CAMK2D/UQCRFS1/UQCRH/NDUFC2/CALM1/UQCRC2/EIF2S1/NFE2L2/UBE2L6/HTRA2/NDUFB3/MAPK8/APAF1/ITPR1/SOD1/PLCG1/TUBB2A/NDUFAB1/PSMD9/ATP5MC3/COX7A2L/COX7A2/PSMC2/KLC1/ITPR3/CALM2/NDUFA7/EIF2AK3/MCU/NDUFA8/GNAS/CASP9/KIF5C/ITPR2/NDUFA9/MAPK9	2.34006280845855
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	29/1948	94/9376	1.48490541308052	CASP3/CASP8/JUND/HSP90AB1/HSP90AA1/TRAF5/MAPK1/NFKB1/USP25/SRSF1/ANAPC5/TBK1/TRAF3/MAPK13/IKBKB/TRAF6/MAPK8/IFNG/TRAF4/RELA/IKBKE/ELAVL1/FOSB/TNFAIP3/CEBPB/MAP3K7/CHUK/PTGS2/MAPK9	2.41960427937464
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/1948	71/9376	1.55918674263239	GLS/KRAS/HIF1A/MAPK1/PFKP/PTEN/PDHA1/PIK3CD/SLC7A5/MAP2K2/PIK3CA/AKT1/KIT/LDHB/MAP2K1/IDH1/SIRT6/G6PD/PIK3R1/TIGAR/RAF1/PDHB/LDHA	2.421988178376
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	30/1948	99/9376	1.4585277829631	CDKN1B/PRKACB/KRAS/MAPK1/MDM2/SOS2/RPS6KB1/BCL2/PIK3CD/NCOA3/NCOR1/CDKN2C/MAP2K2/SOS1/PIK3CA/MAPK13/MAPK8/AKT1/MAP2K1/BRAF/ADCY7/RB1/PIK3R1/MED1/E2F3/RAF1/ADCY3/GNAS/DLL1/MAPK9	2.34867887387437
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	30/1948	99/9376	1.4585277829631	PRKACB/PPP1CB/PLCG2/PTGER4/PPP1CC/PTGER2/PIK3CD/PRKCA/PRKCH/PRKCQ/CAMK2D/PIK3CA/MAPK13/CALM1/MAPK8/TRPV2/MAP2K6/ITPR1/PLCG1/PLCB2/MAP2K3/ADCY7/PIK3R1/ITPR3/CALM2/PLCB1/ADCY3/GNAS/ITPR2/MAPK9	2.34867887387437
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	41/1948	144/9376	1.37040839607575	CASP3/TRA2A/CASP8/CTNNB1/LEF1/LPIN2/TRA2B/NFKB1/SIRT1/TBK1/LPIN1/FASLG/IRF3/ACADM/TRAF3/MAPK13/TCF7/PRKAA1/ACACA/IKBKB/TRAF6/ACADVL/ACOX1/MAPK8/ADIPOR2/MAP2K6/AKT1/FAS/RELA/IKBKE/MAP2K3/ALDH9A1/IRAK4/SREBF1/MAP3K7/CHUK/MAP3K14/ALDH3A2/PRKAG2/TAB1/MAPK9	2.29381473054214
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/1948	31/9376	1.86315161952706	HSPA5/SRP54/SPCS3/SRP9/SRP19/SPCS1/SRP72/SPCS2/SEC61B/SRPRA/SEC11A/SRPRB	2.46503137142763
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	47/1948	170/9376	1.33069211257398	KRAS/CTNNB1/CSNK1A1/PLCG2/LEF1/BRD7/MAPK1/ARID1B/SMARCA2/PTEN/SOS2/RPS6KB1/SMARCE1/SMARCC2/PIK3CD/PRKCA/TGFBR2/ARID2/PHF10/MAP2K2/DPF3/GADD45A/SOS1/SMARCC1/PIK3CA/TCF7/NFE2L2/PBRM1/SMAD4/ACTL6A/AKT1/PLCG1/TGFB1/MAP2K1/BAK1/BRAF/RB1/ELK1/PIK3R1/APC/FRAT2/E2F3/AXIN1/RAF1/GSTM2/GSTM4/SMARCD1	2.2282144120449
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	38/1948	133/9376	1.37518333822235	PRKACB/PPP2R5C/GNG2/PPP1CB/PPP2R5A/PPP3CA/GNAI3/PPP3CC/PPP1CC/PPP2R2A/PPP2CA/PRKCA/PPP2R3C/ARRB2/CAMK2D/ATF2/MAPK13/CALM1/PPP2R2D/MAPK8/ATF6B/PPP2R2B/CREB1/ITPR1/AKT1/GNG5/GNB5/PLCB2/ITPR3/PPP3CB/CALM2/PLCB1/GNGT2/GNAS/GSK3A/KIF5C/ITPR2/MAPK9	2.23155222020245
NA	NA	hsa04517	IgSF CAM signaling	77/1948	299/9376	1.23950471455159	SRGAP3/NCAM1/SH2D1A/DOK2/LCK/ITGA4/CD96/SPTAN1/CTNNB1/PLCG2/ARF6/CDC42/MAPK1/MBP/CRTAM/RAP1A/LY9/ARPC5L/RAP1B/CD48/NCK1/MYL12A/MSN/ACTR2/CD2/LCP2/PIK3CD/SLAMF6/VAV3/PRKCA/ACTR3/SH2D1B/TUBA1A/PRKCQ/VAV1/TUBA4A/RAPGEF6/TIGIT/CSK/MAP2K2/ARPC1B/ICAM3/SLAMF1/SLAMF7/PIK3CA/CASK/CD2AP/MAPK13/MYL12B/INPP5D/TRAF6/DYNLL2/MAPK8/PAK2/ITGAX/AKT1/PLCG1/CD226/TUBB2A/MAP2K1/EZR/IQGAP1/SRGAP2/ARPC3/NCK2/PIK3R1/PLXNA3/CD244/CD28/SSX2IP/PARD6B/LMO7/DYNLL1/FYN/ACTR3C/PDPK1/MAPK9	2.15537410127026
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/1948	62/9376	1.55262634960588	HSPA1A/HSPA1B/HSPA8/HSPA6/PRKACB/KRAS/SIRT1/RPS6KB1/PIK3CD/CAT/PIK3CA/ATG5/PRKAA1/AKT1/SOD1/HDAC1/ADCY7/PIK3R1/ADCY3/PRKAG2	2.23564829832701
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	32/1948	110/9376	1.40018667164458	PRKACB/HSP90AB1/HSP90AA1/KRAS/MAPK1/GNAI3/PIK3CD/ANAPC5/STK10/MAD1L1/PIK3CA/MAPK13/ANAPC16/ANAPC10/ANAPC4/ANAPC1/MAPK8/CDC26/AKT1/MAP2K1/BUB1/BRAF/ADCY7/PIK3R1/SPDYE16/RPS6KA3/PDE3B/RPS6KA1/RAF1/ADCY3/MAD2L1/MAPK9	2.16200643271973
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	31/1948	106/9376	1.40761690752005	CDKN1B/HSP90AB1/HSP90AA1/KRAS/CTNNB1/LEF1/MAPK1/NFKB1/MDM2/PTEN/SOS2/BCL2/EP300/PIK3CD/MAP2K2/SOS1/PIK3CA/TCF7/IKBKB/CREB1/AKT1/RELA/MAP2K1/BRAF/RB1/PIK3R1/E2F3/CHUK/RAF1/CASP9/PDPK1	2.16127197617406
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	39/1948	139/9376	1.35044982494497	HSPA1A/HSPA1B/HSPA8/HSPA6/PRKACB/FKBP5/HSP90AB1/FKBP4/HSP90AA1/KRAS/MAPK1/GNAI3/SOS2/BCL2/PIK3CD/NCOA3/NCOA1/MAP2K2/ATF2/SOS1/PIK3CA/KRT10/CALM1/ATF6B/CREB1/ITPR1/AKT1/MAP2K1/PLCB2/ADCY7/PIK3R1/ITPR3/CALM2/PLCB1/RAF1/ADCY3/GNAS/ITPR2/RARA	2.13163058348231
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1948	37/9376	1.691103834841	KRAS/CTNNB1/LEF1/MAPK1/MAP2K2/GADD45A/TCF7/TPR/TFG/MAP2K1/BAK1/BRAF/CCDC6	2.15694039566346
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/1948	56/9376	1.54708125550015	CUL3/PRKACB/CSNK1G3/CSNK1A1/CCND2/BCL2/ARRB2/CSNK1D/CSNK1G2/SPOP/CUL1/GRK2/SMURF2/KIF3A/PTCH2/BTRC/EFCAB7/EVC2	2.10272297119729
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	61/1948	235/9376	1.24936869238499	PRKACB/KRAS/ARID1B/SMARCA2/SOS2/RPS6KB1/NDUFV2/COX20/SMARCE1/COA1/SMARCC2/NDUFB8/SDHD/COX11/NDUFA5/ATP5F1C/KDM3A/SDHA/NDUFB5/DPF3/COA5/ATF2/SOS1/SMARCC1/UQCRFS1/ACSL3/UQCRH/NDUFAF4/NDUFC2/MAPK13/COA6/UQCRC2/PRKAA1/NDUFB3/ACTL6A/NDUFAF1/CREB1/COX19/RHEB/NDUFAB1/TSC2/ATP5MC3/COX7A2L/COX7A2/MAP2K3/ADCY7/SIRT6/NDUFA7/COX10/RPS6KA3/TSC1/RPS6KA1/NDUFAF5/ADCY3/NDUFAF6/NDUFAF7/NDUFA8/GNAS/PRKAG2/SMARCD1/NDUFA9	1.98254553785485
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1948	30/9376	1.76481861738535	PDHA1/SDHD/DLD/SDHA/IDH3A/SUCLG1/ACLY/IDH1/MDH1/DLST/PDHB	2.1485742030087
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/1948	101/9376	1.38199117653038	CASP3/CDKN1B/PIM1/KRAS/STAT3/PLCG2/CDC42/MAPK1/STAT1/NFKB1/BCL2/PIK3CD/PRKCA/DIAPH1/TGFBR2/PIK3CA/MAPK13/SMAD4/MAPK8/AKT1/PLCG1/RELA/TGFB1/PLCB2/STAT5B/PIK3R1/NFATC1/PLCB1/MAPK9	1.97652005857671
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	45/1948	168/9376	1.28923437958346	SOCS1/PIM1/STAT4/IRF9/CCND3/IFNGR1/STAT3/CCND2/MCL1/IL10RA/STAT1/JAK3/PTPN2/SOS2/IL2RB/STAM/BCL2/EP300/IL27RA/STAT2/PIK3CD/CISH/JAK1/SOS1/PIK3CA/SOCS4/IFNG/AKT1/IL23A/IL4R/IL12RB2/IL10RB/PIAS1/STAT5B/PIK3R1/IL21R/IL2RG/SOCS2/TYK2/SOCS3/RAF1/PIAS3/OSM/IL26/PIAS2	1.93716255758454
Organismal Systems	Endocrine system	hsa04924	Renin secretion	21/1948	69/9376	1.46486920810642	PRKACB/ORAI1/PPP3CA/PTGER4/GNAI3/PPP3CC/PTGER2/ADRB1/PPP3R1/CALM1/CREB1/ITPR1/PLCB2/ITPR3/PPP3CB/CALM2/PLCB1/PDE3B/ADRB2/GNAS/ITPR2	1.9846989310907
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	77/1948	308/9376	1.20328542094456	CASP3/CASP8/PSMD12/PSMA6/CYCS/POLR2K/POLR2B/PSMA2/ERN1/TFAM/NRBF2/TBPL1/NDUFV2/EP300/PSMD6/PSMC6/NDUFB8/SIN3A/POLR2C/SDHD/VDAC3/PSMA3/PSMC4/PSMD13/SLC25A5/TUBA1A/PSMD11/VDAC2/NDUFA5/ATP5F1C/TUBA4A/SDHA/PSMA1/NDUFB5/PSMA5/POLR2J/UQCRFS1/POLR2D/UQCRH/DCTN4/NDUFC2/UQCRC2/NDUFB3/MAPK8/APAF1/NRF1/BBC3/CREB1/ITPR1/POLR2H/SOD1/PIK3C3/TUBB2A/NDUFAB1/HDAC1/PSMD9/ATP5MC3/HTT/DCTN6/COX7A2L/PLCB2/COX7A2/PSMC2/ACTR10/IFT57/KLC1/NDUFA7/PLCB1/ATG2A/NDUFA8/STX1A/CASP9/KIF5C/NDUFA9/TAF4B/WIPI2/MAPK9	1.85767613910041
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	61/1948	238/9376	1.23362034752299	STK4/PRKACB/GNG2/RASA2/RAC2/SHOC2/KRAS/ETS1/PLCG2/RASAL3/ARF6/CDC42/MAPK1/NFKB1/SOS2/RAP1A/RAP1B/RALGAPA1/PIK3CD/PRKCA/RASSF1/ZAP70/LAT/TBK1/RASSF5/MAP2K2/FASLG/SOS1/PIK3CA/EXOC2/CALM1/RALGAPA2/IKBKB/RASGRP1/RAB5A/MAPK8/PAK2/RALGDS/AKT1/KIT/GNG5/REL/PLCG1/GNB5/RELA/MAP2K1/NF1/RASA3/ELK1/PIK3R1/CSF1/CALM2/RGL2/SYNGAP1/BRAP/RRAS2/CHUK/GNGT2/RAF1/RALB/MAPK9	1.86946670249058
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1948	20/9376	1.92525667351129	LBR/SC5D/HSD17B7/FDFT1/MSMO1/EBP/SQLE/CYP51A1	2.12117394725053
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	38/1948	140/9376	1.30642417131124	PRKACB/GNG2/KRAS/MAP1LC3B/MAPK1/GNAI3/TFAM/RPS6KB1/CAMK4/GNA13/KLF2/MAP2K2/PIK3CG/CALM1/PRKAA1/SPHK2/SMAD4/NRF1/ITPR1/AKT1/GNG5/PIK3C3/GNB5/MAP2K1/MEF2D/PLCB2/ADCY7/PIK3R6/ITPR3/CALM2/PLCB1/RRAS2/GNGT2/PDE3B/RAF1/ADCY3/PRKAG2/ITPR2	1.87063580586708
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	21/1948	71/9376	1.42360528675131	CASP3/PLCG2/CDC42/NFKB1/ATP6V0E2/ATP6V1H/ADAM10/CSK/ATP6V1G1/MAPK13/IKBKB/MAPK8/ADAM17/PLCG1/TCIRG1/RELA/CCL5/CHUK/ATP6V0A2/MAP3K14/MAPK9	1.83474842765313
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1948	14/9376	2.06277500733353	B3GNT2/B4GALT1/B4GALT4/B4GALT3/B3GNT7/FUT8	2.03781708572246
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1948	32/9376	1.65451745379877	PPP2CA/ATG12/ATG16L1/ATG3/ATG5/IGBP1/GABARAPL2/PIK3C3/GABARAPL1/ATG2A/WIPI2	1.89921430799405
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	35/1948	130/9376	1.29584583794029	PRKACB/GNG2/KRAS/MAPK1/GNAI3/NFKB1/SOS2/PIK3CD/PRKCA/TGFBR2/ARRB2/MAP2K2/ATF2/SOS1/PIK3CA/MAPK13/MAPK8/ATF6B/CREB1/AKT1/GNG5/GNB5/RELA/TGFB1/MAP2K1/PLCB2/ADCY7/PIK3R1/PLCB1/GNGT2/RAF1/INSL3/ADCY3/GNAS/MAPK9	1.73941961178362
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	23/1948	80/9376	1.38377823408624	BCL2L11/KRAS/STAT3/PLCG2/MAPK1/PTEN/SOS2/RPS6KB1/BCL2/PIK3CD/PRKCA/JAK1/MAP2K2/SOS1/PIK3CA/EIF4E/AKT1/PLCG1/MAP2K1/NF1/BRAF/PIK3R1/RAF1	1.76531187669797
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/1948	44/9376	1.53145417211126	PRKACB/VAMP2/DCTN4/NSF/DYNLL2/RAB5A/STX4/CREB1/DCTN6/ARHGDIB/DYNLL1/ADCY3/GNAS/AQP3	1.80945989115463
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	33/1948	122/9376	1.301915373481	PPP2R5C/PPP2R5A/PFKP/SIRT1/RPS6KB1/PPP2R2A/PIK3CD/PPP2CA/RAB8A/PPP2R3C/PIK3CA/HMGCR/RAB14/PPP2R2D/PRKAA1/ACACA/PFKFB3/ADIPOR2/PPP2R2B/CREB1/AKT1/RHEB/TSC2/CAB39/ELAVL1/PIK3R1/SREBF1/TBC1D1/MAP3K7/STK11/TSC1/PRKAG2/PDPK1	1.71887605834352
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/1948	204/9376	1.22687925272779	CASP3/DDX5/PRKACB/PPP1CB/ARHGEF1/KRAS/STAT3/CTNNB1/PLCG2/HIF1A/CDC42/MAPK1/MDM2/SOS2/RPS6KB1/HCLS1/PPP1CC/PDCD4/MSN/PIK3CD/VAV3/PRKCA/VAV1/NUDT16L1/MAP2K2/FASLG/CAMK2D/SOS1/PIK3CA/CBL/MAPK13/EIF4B/ROCK1/ITPR1/AKT1/PLCG1/FAS/TGFB1/MAP2K1/EZR/IQGAP1/PPP1R12A/BRAF/CD44/ELK1/PIK3R1/ITPR3/RRAS2/ARHGEF12/RAF1/ITPR2/PDPK1	1.67772976952425
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	46/1948	178/9376	1.24384560367303	CACYBP/PRKACB/RAC2/CCND3/CTNNB1/CCDC88C/CSNK1A1/PPP3CA/CCND2/LEF1/PPP3CC/SIRT1/EP300/TBL1XR1/CHD8/PRKCA/TLE4/SENP2/SKP1/CAMK2D/CSNK2A1/PPP3R1/INVS/TCF7/SMAD4/MAPK8/SIAH1/CUL1/NFATC3/RYK/PLCB2/APC/FRAT2/PPP3CB/NFATC1/PLCB1/MAP3K7/PSEN1/NFATC2/AXIN1/PPARD/TLE3/BTRC/CTNNBIP1/CSNK2A2/MAPK9	1.68198607313839
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	20/1948	69/9376	1.39511353152992	PRKACB/PPP1CB/PPP3CA/PPP3CC/SIRT1/PPP1CC/CAMK4/PRKCA/CAMK2D/ATF2/PPP3R1/CALM1/ATF6B/CREB1/HDAC1/FOSB/PPP3CB/CALM2/GNAS/STX1A	1.68688609615845
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1948	116/9376	1.28627062238901	ITK/CXCR4/TXK/RAC2/ITGA4/CTNNB1/PLCG2/CDC42/GNAI3/RAP1A/RHOH/RAP1B/MYL12A/MSN/PIK3CD/VAV3/PRKCA/VASP/VAV1/RASSF5/PIK3CA/MAPK13/MYL12B/SIPA1/NCF4/ROCK1/OCLN/PLCG1/EZR/PIK3R1/CD99	1.58870934610363
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1948	34/9376	1.55719289769296	BHLHE40/NFIL3/CSNK1D/SKP1/PRKAA1/CREB1/CUL1/PER1/FBXL3/BTRC/PRKAG2	1.66674540305031
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	56/1948	227/9376	1.18738297044749	KRAS/PRKD3/HIF1A/MAPK1/NFKB1/PTEN/SOS2/ACP1/NDUFV2/NDUFB8/PIK3CD/SDHD/VDAC3/SLC25A5/VDAC2/NDUFA5/ATP5F1C/ARNT/CAT/SDHA/MAP2K2/NDUFB5/AHR/SOS1/PIK3CA/UQCRFS1/UQCRH/NDUFC2/MAPK13/UQCRC2/IKBKB/NFE2L2/NDUFB3/MAPK8/AKT1/SOD1/RELA/NDUFAB1/MAP2K1/ATP5MC3/COX7A2L/COX7A2/BRAF/PIK3R1/NDUFA7/CHUK/PTPRJ/RAF1/EPHX2/GSTM2/MAP3K14/NDUFA8/GSTM4/PDPK1/NDUFA9/MAPK9	1.46352586098019
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/1948	205/9376	1.19741573596434	RAC2/PPP1CB/NFKB1/PTEN/MPC2/PPP1CC/NDUFV2/PDK3/NDUFB8/PDHA1/PIK3CD/SDHD/VDAC3/PRKCA/SLC25A5/VDAC2/TGFBR2/NDUFA5/ATP5F1C/SDHA/NDUFB5/CAMK2D/GSR/PIK3CA/UQCRFS1/UQCRH/NDUFC2/MAPK13/PARP1/UQCRC2/NCF4/ATP2A2/NDUFB3/MAPK8/MPC1/AKT1/RELA/TGFB1/NDUFAB1/ATP5MC3/COX7A2L/PLCB2/COX7A2/G6PD/PIK3R1/NDUFA7/PLCB1/NDUFA8/PDHB/NDUFA9/MAPK9	1.46350603606552
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	42/1948	166/9376	1.21778283565473	PPP1CB/PPP3CA/MAPK1/GNAI3/PPP3CC/PPP1CC/VDAC3/SLC25A5/ADRB1/GNA13/VDAC2/VASP/MAP2K2/ATF2/PPP3R1/PIK3CG/ATP1A1/CALM1/ATP2A2/ROCK1/ATF6B/CREB1/ITPR1/AKT1/NFATC3/MAP2K1/MEF2D/PPP1R12A/PLCB2/ADCY7/PIK3R6/ITPR3/PPP3CB/CALM2/NFATC1/PLCB1/NFATC2/PDE3B/ADRB2/RAF1/ADCY3/ITPR2	1.44974641715773
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	14/1948	47/9376	1.43370177814671	ME2/PDHA1/DLD/ACYP1/ACACA/LDHB/ALDH9A1/ACAT2/MDH1/ALDH3A2/ACYP2/PDHB/HAGH/LDHA	1.52639435804525
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/1948	89/9376	1.29792584731098	PRKACB/KRAS/MAPK1/GNAI3/SOS2/PRKCA/ADRB1/TUBA1A/TUBA4A/CSNK1D/MAP2K2/SOS1/ITPR1/MAP3K2/TUBB2A/MAP2K1/PLCB2/ADCY7/ITPR3/PLCB1/RAF1/ADCY3/GNAS/ITPR2	1.4461376419749
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	58/1948	238/9376	1.17295049436612	MX1/RPS10/ADAR/OAS2/EIF2AK2/OAS1/RPL36A/CGAS/IRF9/RPL26/STAT3/RPS21/PLCG2/RSL24D1/MAPK1/STAT1/CASP1/NFKB1/RPL22L1/STAT2/RPL17/RPS15A/OAS3/PIK3CD/MX2/PRKCA/JAK1/TBK1/RPL37/PIK3CA/IRF3/RPL41/TRAF3/MAPK13/IKBKB/TRAF6/IFIH1/RPS29/MAPK8/RPL14/ADAM17/PLCG1/RELA/IKBKE/RPS25/IRAK4/PIK3R1/RPS7/ISG15/RPL39/MAP3K7/CHUK/RPS27/TYK2/RPL30/FAU/RPS23/MAPK9	1.38397701152693
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	30/1948	115/9376	1.25560217837693	JUND/PRKACB/ARHGEF1/MAPK1/GNAI3/PDE4B/BCL2/STK39/PRKCA/GNA13/ARRB2/ATF2/GATA3/ATF6B/CREB1/ITPR1/MAP2K1/MEF2D/PLCB2/TNFSF11/BRAF/OXSR1/ADCY7/ITPR3/RUNX2/PLCB1/RAF1/ADCY3/GNAS/ITPR2	1.41230564762137
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1948	32/9376	1.5041067761807	HIBCH/ECHDC1/DLD/ACACA/ACOX1/SUCLG1/LDHB/ALDH6A1/BCKDHB/LDHA	1.46276741211777
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	18/1948	65/9376	1.33287000473859	KRAS/MAPK1/PIK3CD/PRKCA/ARRB2/MAP2K2/PIK3CA/ITPR1/AKT1/MAP2K1/PLCB2/PIK3R1/ITPR3/PLCB1/RAF1/GNRH1/KCNN1/ITPR2	1.3790415265873
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	56/1948	232/9376	1.16179282022233	CXCR4/RAC2/PPP1CB/FGD3/ITGA4/ARHGEF1/KRAS/PIP4K2A/CDC42/MAPK1/SOS2/PPP1CC/ARPC5L/ITGAE/MYL12A/MSN/SSH2/ACTR2/ARHGEF6/IQGAP2/PIK3CD/NCKAP1L/VAV3/ACTR3/DIAPH1/GNA13/VAV1/MAP2K2/ARPC1B/SPATA13/SOS1/PIK3CA/MYL12B/CYFIP2/ROCK1/PAK2/ITGB7/TMSB4X/ITGAX/AKT1/MAP2K1/EZR/IQGAP1/ARPC3/PPP1R12A/PIP5K1A/BRAF/PIK3R1/APC/RRAS2/CRKL/LPAR2/ARHGEF12/ARHGEF7/RAF1/ACTR3C	1.27784828955355
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	49/1948	201/9376	1.17335294778673	DDX5/ATM/CDKN1B/ELK4/TRAF1/CCND2/JMJD1C/NFKB1/MDM2/TAF15/IL2RB/CCNT2/KDM6A/BIRC2/DDIT3/SIN3A/NCOR1/FLI1/TGFBR2/MAX/CCNT1/FUS/EWSR1/CDKN2C/GADD45A/TCF3/ID2/CDK9/MLLT3/GZMB/NFKBIZ/ITGB7/KMT2A/REL/RELA/SUPT3H/NSD2/AFF1/HDAC1/ATF1/BCL6/BIRC3/BAK1/LDB1/RUNX2/CEBPB/SS18/FUT8/RARA	1.27224393799351
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	42/1948	170/9376	1.18912912187462	RAB8B/PRKACB/WHAMM/WAS/CDC42/RAP2C/HSPA4/RAP1A/HCLS1/ARPC5L/PPP2R2A/MYL12A/MSN/ACTR2/PPP2CA/ACTR3/RAB8A/TUBA1A/VASP/TUBA4A/RAPGEF6/ARPC1B/PATJ/MYL12B/PPP2R2D/PRKAA1/LLGL2/DLG3/ROCK1/MAPK8/PPP2R2B/OCLN/EZR/ARPC3/MAP3K1/ARHGAP17/STK11/PARD6B/ACTR3C/DLG1/PRKAG2/MAPK9	1.27435829000654
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	22/1948	83/9376	1.27577249449544	ECI2/AGPS/CAT/FAR1/ACSL3/ACOX1/PEX16/FAR2/SOD1/PEX2/ECH1/IDH1/PEX26/CROT/MPV17L/ABCD2/SCP2/EPHX2/ACOT8/PEX13/PECR/SLC27A2	1.29227871775863
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	18/1948	66/9376	1.31267500466679	STAT4/IFNGR1/STAT3/IL18R1/STAT1/NFKB1/IL18RAP/TBX21/GATA3/IFNG/IL23A/IL4R/RELA/TGFB1/IL12RB2/NFATC1/IL21R/IL2RG	1.30537249984707
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	12/1948	41/9376	1.40872439525217	ATM/UIMC1/TOPBP1/NBN/MRE11/RPA3/RPA1/PALB2/BRCA2/RAD51C/BARD1/POLD4	1.34310354095074
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1948	41/9376	1.40872439525217	KRAS/MAPK1/MDM2/RASSF1/MAP2K2/MAP2K1/RPS6KA5/BRAF/RB1/E2F3/RAF1/DAPK2	1.34310354095074
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	51/1948	212/9376	1.15787842392778	EVL/RAC2/KRAS/CTNNB1/SKAP1/PRKD3/CDC42/MAPK1/GNAI3/RAP1A/RAP1B/APBB1IP/RGS14/LCP2/PIK3CD/VAV3/PRKCA/LAT/VASP/VAV1/RASSF5/RAPGEF6/MAP2K2/PIK3CA/MAPK13/CALM1/SIPA1/RAPGEF1/MAP2K6/RALGDS/AKT1/KIT/PLCG1/MAP2K1/PLCB2/BRAF/MAP2K3/ADCY7/SIPA1L1/PIK3R1/CSF1/CALM2/PLCB1/CRKL/LPAR2/PARD6B/RAF1/ADCY3/GNAS/SIPA1L3/RALB	1.19067254444012
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	38/1948	154/9376	1.18765833755567	PRKACB/PPP1CB/KRAS/PPP3CA/MAPK1/GNAI3/CD38/PPP3CC/PPP1CC/CAMK4/PRKCA/MAP2K2/CAMK2D/PPP3R1/PIK3CG/CALM1/PRKAA1/ROCK1/ITPR1/NFATC3/MAP2K1/PPP1R12A/PLCB2/ADCY7/ELK1/PIK3R6/ITPR3/PPP3CB/CALM2/NFATC1/PLCB1/NFATC2/RAF1/ADCY3/GNAS/PTGS2/PRKAG2/ITPR2	1.20243008283881
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	15/1948	54/9376	1.33698380104951	ATR/FANCF/MLH1/WDR48/USP1/REV1/ERCC1/POLH/RPA3/RPA1/PALB2/BRCA2/RAD51C/PMS2/UBE2T	1.27173177403515
Genetic Information Processing	Translation	hsa03010	Ribosome	53/1948	222/9376	1.14908337495606	RPS10/RPL36A/RPL26/RPS21/MRPS31/RSL24D1/MRPS30/MRPL3/MRPS17/MRPL18/RPL22L1/MRPL9/RPL17/RPS15A/MRPL44/MRPS18C/MRPS15/MRPL34/RPL37/MRPL14/MRPL39/MRPL10/MRPL19/MRPL22/MRPL1/RPL41/MRPL47/MRPS14/MRPL49/MRPL52/MRPS7/RPS29/RPL14/MRPL38/MRPL50/MRPL13/MRPL32/MRPS35/RPS25/MRPL30/RPS7/MRPS23/RPL39/DAP3/RPS27/MRPL35/RPL30/MRPS27/FAU/MRPL4/MRPL42/MRPL48/RPS23	1.15118312808137
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/1948	38/9376	1.39327785583054	SIRT7/CD38/SIRT1/NNT/PNP/SIRT2/NAMPT/SIRT6/NT5C2/NADSYN1/SIRT5	1.24396603855219
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1948	59/9376	1.30525876170257	NT5C3A/DCK/UPP1/DPYD/CTPS1/CMPK1/DTYMK/HDDC2/DUT/CDADC1/NT5C2/ENTPD4/UCKL1/NME3/CMPK2/DHODH	1.20448185844204
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/1948	85/9376	1.24575431815437	NT5C3A/DCK/UPP1/HPRT1/CTPS1/ADA/PNP/NTPCR/DGUOK/CMPK1/GMPS/GMPR2/DTYMK/HDDC2/DUT/NT5C2/ENTPD4/AMPD2/UCKL1/NME3/ADSL/CMPK2	1.1655302706844
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/1948	55/9376	1.31267500466679	DEGS1/UGCG/SPTLC2/SPHK2/SGMS1/NEU1/CERS2/SPTLC1/NEU3/CERS6/CERS5/SAMD8/SMPD3/B4GALT5/SGPP1	1.19093325569933
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1948	51/9376	1.32125457986069	PRKACB/PLCG2/ATP6V0E2/PRKCA/ATP6V1H/ATP6V1G1/ERO1A/SEC61B/ARF1/PLCG1/TCIRG1/ATP6V0A2/ADCY3/GNAS	1.17802406521008
Organismal Systems	Nervous system	hsa04730	Long-term depression	16/1948	60/9376	1.28350444900753	KRAS/MAPK1/GNAI3/PPP2CA/PRKCA/GNA13/MAP2K2/ITPR1/MAP2K1/PLCB2/BRAF/ITPR3/PLCB1/RAF1/GNAS/ITPR2	1.12814502052113
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1948	43/9376	1.34320233035672	ECI2/ACSL3/ACADM/ACAA2/ACADVL/ACOX1/GCDH/HADHB/ALDH9A1/HADH/ACAT2/ALDH3A2	1.15509576047653
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1948	56/9376	1.28923437958346	ALG13/B4GALT1/STT3B/MGAT4A/MGAT2/MAN1A1/OSTC/MGAT5/MOGS/MAGT1/DDOST/B4GALT3/DAD1/FUT8/DPM1	1.11168088450431
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1948	44/9376	1.31267500466679	ALG13/B4GALT1/STT3B/MGAT4A/MGAT2/MAN1A1/OSTC/MAGT1/DDOST/B4GALT3/DAD1/FUT8	1.06457510280436
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1948	57/9376	1.26661623257322	HACD4/ACSL3/ACADM/ACAA2/ACACA/ACADVL/ACOX1/ELOVL5/ELOVL6/HADHB/HADH/HSD17B12/ACAT2/SCP2/ACSF3	1.03391188162485
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	37/1948	155/9376	1.14894349870835	CDKN1B/PRKACB/CTNNB1/ORAI1/LEF1/MAPK1/GNAI3/RAP1A/RAP1B/ARNT/CDKN2C/MAP2K2/AHR/CAMK2D/ATF2/ASH2L/TCF7/ATF6B/CREB1/ITPR1/KMT2A/AIP/MAP2K1/PLCB2/BRAF/ADCY7/RB1/APC/ITPR3/PLCB1/E2F3/CDKN2B/AXIN1/RBBP5/ADCY3/GNAS/ITPR2	0.957508319896849
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	28/1948	115/9376	1.17189536648514	PRKACB/GNG2/KRAS/MAPK1/GNAI3/BCL2/PIK3CD/CAMK4/PRKCA/CAMK2D/PIK3CA/PIK3CG/CREB1/ITPR1/AKT1/GNG5/GNB5/MAP2K1/PLCB2/ADCY7/PIK3R1/PIK3R6/ITPR3/PLCB1/GNGT2/ADCY3/FYN/ITPR2	0.949791580136287
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1948	49/9376	1.27695595692076	OGT/B4GALT1/GALNT3/C1GALT1/LFNG/FUT10/MFNG/GALNT11/B4GALT3/GALNT1/GXYLT1/GALNT10/GALNT2	0.995363999831134
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/1948	28/9376	1.37518333822235	HACD4/THEM4/ACAA2/ELOVL5/ELOVL6/HADHB/HADH/HSD17B12	1.01813970448772
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/1948	116/9376	1.16179282022233	ME2/HIBCH/PFKP/PDHA1/PGP/SDHD/DLD/CAT/SDHA/PGK1/IDH3A/GLUD1/TKT/ACOX1/SUCLG1/RPIA/ALDH6A1/IDH1/TALDO1/G6PD/ACAT2/ESD/MDH1/DLST/GLYCTK/PSAT1/PDHB/ADPGK	0.897897812477568
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	50/1948	217/9376	1.10901882114706	PTGES3/PRKACB/HSP90AB1/HSP90AA1/CCND3/KRAS/STAT3/MAPK1/KPNA4/GNAI3/NFKB1/SOS2/RPS6KB1/BCL2/PIK3CD/KPNA2/PRKCA/ADRB1/ARNT/ARRB2/MAP2K2/AHR/ATF2/SOS1/PIK3CA/KPNA5/ATF6B/CREB1/AKT1/AIP/KPNA1/RELA/IKBKE/MAP2K1/BCL6/TNFSF11/ADCY7/RB1/STAT5B/PIK3R1/RPS6KA3/ADRB2/RPS6KA1/RAF1/EPHX2/ADCY3/GSTM2/GNAS/GSTM4/DLL1	0.83205394856985
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1948	104/9376	1.15700521244669	ETNK1/GPCPD1/DGKZ/LPIN2/DGKD/DGKA/SELENOI/LPIN1/LPCAT3/ADPRM/DGKE/LPCAT4/SGMS1/PGS1/CRLS1/CHKB/PTDSS1/LPGAT1/AGPAT5/CEPT1/MBOAT1/SAMD8/AGPAT2/CHKA/AGPAT3	0.824495322163109
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/1948	78/9376	1.17243194861265	CASP3/IRF1/MAPK1/CASP1/GNAI3/NFKB1/PYCARD/IRF3/MAPK13/CALM1/TRAF6/MAPK8/CASP7/IL23A/RELA/IRAK4/CALM2/IRF8/MAPK9	0.783094968274572
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1948	21/9376	1.37518333822235	DPYD/PANK3/PPCS/AASDHPPT/PANK2/ALDH3A2	0.88140490219037
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1948	110/9376	1.13765167071122	MAPK1/RPS6KB1/EP300/SKIL/SIN3A/PPP2CA/LEMD3/NCOR1/TGFBR2/SKI/TGIF2/SKP1/RBL1/SMAD7/ID2/TFDP1/ROCK1/SMAD4/IFNG/CUL1/TGFB1/HDAC1/ZFYVE16/E2F4/CDKN2B/SMURF2	0.743662442152967
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/1948	70/9376	1.168905837489	CASP3/CASP8/CYCS/RAC2/PRF1/HLA-F/EIF4G2/HLA-B/CD55/EIF4G3/HLA-A/BID/SNTB1/SNTB2/CD28/FYN/CASP9	0.726367362739945
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/1948	203/9376	1.09066264755566	RAC2/PPP1CB/ITGA4/CCND3/CTNNB1/CCND2/CDC42/MAPK1/PTEN/SOS2/RAP1A/PPP1CC/RAP1B/BCL2/MYL12A/BIRC2/PIK3CD/VAV3/PRKCA/DIAPH1/VASP/VAV1/CAPN2/PARVG/SOS1/PIK3CA/MYL12B/RAPGEF1/ROCK1/MAPK8/PAK2/ITGB7/AKT1/MAP2K1/PPP1R12A/BIRC3/PIP5K1A/BRAF/ELK1/PIK3R1/CRKL/COL9A2/RAF1/FYN/PDPK1/MAPK9	0.66875168060779
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	36/1948	157/9376	1.10365032239501	MOB1A/PPP1CB/CCND3/CTNNB1/CCND2/LEF1/PPP1CC/PPP2R2A/BIRC2/PPP2CA/RASSF1/TGFBR2/YWHAZ/CSNK1D/TP53BP2/PATJ/SMAD7/ID2/PPP2R2D/TCF7/AREG/LLGL2/DLG3/SMAD4/BBC3/PPP2R2B/LATS1/TGFB1/YWHAB/BIRC3/APC/AXIN1/PARD6B/BTRC/DLG1/MOB1B	0.670691408220446
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/1948	75/9376	1.15515400410678	HSPA5/PRKACB/PRKCA/TTF1/ATF2/TTF2/GSR/ATP1A1/ATF6B/CREB1/ITPR1/PLCB2/ADCY7/ITPR3/PLCB1/ADCY3/GNAS/ITPR2	0.690832824274109
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/1948	44/9376	1.20328542094456	HSPD1/PRF1/HLA-F/HLA-B/FASLG/GZMB/IFNG/FAS/HLA-A/CD28/PTPRN2	0.69213270862922
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/1948	45/9376	1.17654574492357	KLRD1/KLRC1/PRF1/HLA-F/HLA-B/FASLG/GZMB/IFNG/FAS/HLA-A/CD28	0.607916013894156
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1948	59/9376	1.14210141648975	PRKACB/GNAI3/PIK3CD/ADRB1/PIK3CA/AKT1/ADCY7/PIK3R1/ABHD5/PDE3B/ADRB2/ADCY3/GNAS/PTGS2	0.560699968990864
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/1948	78/9376	1.11072500394882	ITGA4/IFNGR1/MAPK1/STAT1/NFKB1/JAK1/MARCKSL1/MAPK13/NCF4/TRAF6/IFNG/RELA/TGFB1/IRAK4/ELK1/MAP3K7/PTGS2/TAB1	0.502854570467611
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1948	19/9376	1.26661623257322	PDHA1/DLD/DLST/BCKDHB/PDHB	0.595715966080373
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1948	154/9376	1.06264167044455	PRKACB/PPP2R5C/PPP1CB/PPP2R5A/MAPK1/GNAI3/PPP1CC/PPP2R2A/BCL2/PPP2CA/PRKCA/ADRB1/PPP2R3C/CAMK2D/ATF2/PIK3CG/ATP1A1/MAPK13/CALM1/PPP2R2D/ATP2A2/ATF6B/PPP2R2B/CREB1/AKT1/RPS6KA5/PLCB2/ADCY7/PIK3R6/CALM2/PLCB1/ADRB2/ADCY3/GNAS	0.401379602755204
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1948	70/9376	1.10014667057788	STAT3/NFKB1/PRKCQ/ACSL3/PRKAA1/IKBKB/MAPK8/ADIPOR2/AKT1/RELA/NFKBIE/CHUK/STK11/SOCS3/PRKAG2/MAPK9	0.430673528376897
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1948	47/9376	1.12647996854384	SOCS1/MAPK1/PIK3CD/PIK3CA/SOCS4/IKBKB/MAPK8/PIK3R1/SOCS2/SOCS3/MAPK9	0.445140693718242
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1948	184/9376	1.04633514864744	SRGAP3/CXCR4/RAC2/SEMA4D/KRAS/PLCG2/PPP3CA/CDC42/MAPK1/GNAI3/PPP3CC/NCK1/MYL12A/SSH2/PIK3CD/PRKCA/LRIG2/CAMK2D/PIK3CA/PPP3R1/MYL12B/ROCK1/PAK2/PLCG1/NFATC3/RYK/SRGAP2/NCK2/SEMA4F/PIK3R1/PLXNA3/PPP3CB/NFATC2/EPHB6/ARHGEF12/PARD6B/RAF1/FYN/RGS3/PDPK1	0.325056332624108
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/1948	39/9376	1.11072500394882	PRF1/HLA-F/HLA-B/FASLG/GZMB/IFNG/FAS/HLA-A/CD28	0.354828500151002
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	32/1948	148/9376	1.04067928297908	KRAS/CTNNB1/CSNK1A1/LEF1/MAPK1/PTEN/SOS2/RPS6KB1/PIK3CD/NCOA3/NCOA1/MAP2K2/GADD45A/SOS1/PIK3CA/TCF7/NFKB2/AKT1/KIT/MAP2K1/TNFSF11/BAK1/BRAF/RB1/PIK3R1/APC/FRAT2/E2F3/AXIN1/RAF1/BRCA2/DLL1	0.255443302925673
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1948	101/9376	1.04840709943684	PRKACB/KRAS/CTNNB1/LEF1/MAPK1/GNAI3/EP300/PRKCA/MAP2K2/CAMK2D/CALM1/TCF7/CREB1/KIT/MAP2K1/PLCB2/ADCY7/CALM2/PLCB1/RAF1/ADCY3/GNAS	0.250470714751777
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1948	54/9376	1.06958704083961	AMD1/MAT2A/DNMT3A/LDHB/MAT2B/DNMT1/MRI1/MDH1/MTAP/APIP/PSAT1/LDHA	0.262612180826486
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1948	73/9376	1.05493516356783	KRAS/MAPK1/MDM2/PTEN/PIK3CD/MAP2K2/GADD45A/PIK3CA/AKT1/MAP2K1/BAK1/BRAF/RB1/PIK3R1/E2F3/RAF1	0.241292880782829
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/1948	97/9376	1.04202036452931	PRKACB/GNG2/MAPK1/GNAI3/PRKCA/CAMK2D/CALM1/CREB1/ITPR1/GNG5/GNB5/RPS6KA5/PER1/PLCB2/ADCY7/ITPR3/CALM2/PLCB1/GNGT2/ADCY3/GNAS	0.213029261748945
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/1948	45/9376	1.06958704083961	TAP1/ABCG1/ABCB1/TAP2/ABCA5/ABCC1/ABCB7/ABCD2/ABCA2/ABCC5	0.239615384127316
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	32/1948	150/9376	1.02680355920602	CDKN1B/KRAS/CTNNB1/CSNK1A1/LEF1/MAPK1/SOS2/RPS6KB1/BCL2/PIK3CD/TGFBR2/ABCB1/MAP2K2/GADD45A/SOS1/PIK3CA/TCF7/SMAD4/MLH1/AKT1/TGFB1/MAP2K1/BAK1/BRAF/RB1/PIK3R1/APC/FRAT2/E2F3/CDKN2B/AXIN1/RAF1	0.169463252883183
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1948	12/9376	1.20328542094456	NCAM1/CD46/SLAMF1	0.360836383000745
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1948	31/9376	1.08683844472412	PFKP/TKT/RPIA/PGM2/TALDO1/G6PD/GLYCTK	0.247997554135648
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1948	31/9376	1.08683844472412	HIBCH/DPYD/CNDP2/ACOX1/ALDH6A1/ALDH9A1/ALDH3A2	0.247997554135648
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1948	98/9376	1.03138750366676	PRKACB/PRKD3/ORAI1/CAMK4/PRKCA/CAMK2D/ATF2/ATP1A1/CALM1/ATF6B/CREB1/ITPR1/ATF1/PLCB2/ADCY7/ITPR3/CALM2/PLCB1/ADCY3/GNAS/ITPR2	0.159950940168758
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1948	36/9376	1.06958704083961	GALNT3/C1GALT1/GCNT1/GALNT11/GALNT1/GALNT10/B4GALT5/GALNT2	0.214215231673346
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1948	65/9376	1.03667667035223	DGKZ/LPIN2/DGKD/DGKA/LPIN1/DGKE/ALDH9A1/AGK/AGPAT5/MBOAT1/GLYCTK/AGPAT2/ALDH3A2/AGPAT3	0.151947158808755
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1948	142/9376	1.01686091910808	RAC2/HSP90AB1/HSP90AA1/CTNNB1/SUMO1/NFKB1/BCL2/SUMO4/PIK3CD/DUSP1/KLF2/SUMO2/PIK3CA/MAPK13/CALM1/PRKAA1/IKBKB/NFE2L2/MAPK8/IFNG/MAP2K6/AKT1/RELA/PIK3R1/CALM2/MAP3K7/CHUK/GSTM2/GSTM4/MAPK9	0.103675144380777
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1948	128/9376	1.01527207392197	PDE7A/PDE4B/PDE6D/DCK/HPRT1/ADA/PNP/ENPP4/NTPCR/DGUOK/ADPRM/GMPS/GMPR2/HDDC2/PGM2/PAPSS1/PPAT/ADCY7/NT5C2/NUDT5/ENTPD4/PDE3B/FHIT/AMPD2/NME3/ADCY3/ADSL	0.0890888306859859
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1948	27/9376	1.06958704083961	HMGCS1/OXCT1/L2HGDH/BDH1/HADH/ACAT2	0.185426515760795
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1948	27/9376	1.06958704083961	HACD4/ACOX1/ELOVL5/ELOVL6/HSD17B12/SCP2	0.185426515760795
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1948	42/9376	1.03138750366676	MAP1LC3B/SLC3A2/VDAC3/VDAC2/ATG5/ACSL3/LPCAT3/SAT2/PRNP	0.104397882583664
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1948	76/9376	1.01329298605858	PRKACB/GNAI3/PRKCA/CAMK2D/ATP1A1/CALM1/ITPR1/EZR/PLCB2/ADCY7/ITPR3/CALM2/PLCB1/ADCY3/GNAS/ITPR2	0.0595843269566368
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	38/1948	183/9376	0.999450185702584	NOP58/XPO1/XRN1/SBDS/WDR43/NXT1/RAN/RIOK2/BMS1/HEATR1/NOP10/UTP6/XRN2/CSNK2A1/GNL3L/LSG1/WDR36/POP5/GTPBP4/NAT10/NXF1/RIOK1/NMD3/RPP38/GNL3/REXO1/TCOF1/NOB1/UTP18/NVL/MDN1/RPP30/UTP14A/EFL1/PWP2/CSNK2A2/RCL1/WDR75	-0.0038464236016724
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1948	18/9376	1.06958704083961	NEU1/NEU3/MANBA/MAN2B1	0.15132729454509
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1948	18/9376	1.06958704083961	MMADHC/LMBRD1/ZNF143/HCFC1	0.15132729454509
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	75/1948	362/9376	0.997197862661236	CDKN1B/BCL2L11/PPP2R5C/GNG2/HSP90AB1/HSP90AA1/ITGA4/CCND3/KRAS/PPP2R5A/CCND2/MCL1/THEM4/MAPK1/JAK3/NFKB1/MDM2/PTEN/SOS2/IL2RB/RPS6KB1/PPP2R2A/BCL2/PIK3CD/PPP2CA/PRKCA/RBL2/PPP2R3C/JAK1/PKN2/YWHAZ/CDC37/MAP2K2/FASLG/ATF2/SOS1/PIK3CA/PIK3CG/EIF4E/PPP2R2D/MYB/EIF4B/PRKAA1/IKBKB/AREG/LPAR6/ATF6B/ITGB7/PPP2R2B/CREB1/AKT1/KIT/GNG5/IL4R/GNB5/RHEB/RELA/MAP2K1/TSC2/YWHAB/PIK3R1/CSF1/PIK3R6/IL2RG/CHUK/GNGT2/LPAR2/STK11/TSC1/COL9A2/DDIT4/RAF1/OSM/CASP9/PDPK1	-0.0278438376289419
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1948	33/9376	1.02096944807417	PDHA1/DLD/IDH3A/IDH1/DLST/BCKDHB/PDHB	0.0617938084410422
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/1948	116/9376	0.995822417333428	GLS/PRKACB/GNG2/SLC38A1/PPP3CA/MAPK1/GNAI3/SLC38A2/PPP3CC/PRKCA/PPP3R1/ITPR1/GRK2/GNG5/GNB5/PLCB2/ADCY7/ITPR3/PPP3CB/PLCB1/GNGT2/ADCY3/GNAS/ITPR2	-0.0231842323571884
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1948	38/9376	1.01329298605858	KRAS/MAPK1/PIK3CD/PRKCA/PIK3CA/ATP1A1/PIK3R1/PDPK1	0.0420466674201483
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1948	78/9376	0.987311114621176	CTNNB1/CDC42/HCLS1/ARPC5L/ACTR2/PIK3CD/ACTR3/ARPC1B/PIK3CA/DNM2/CBL/CD2AP/ARPC3/PIK3R1/CRKL/ACTR3C	-0.0576262251463115
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1948	93/9376	0.983330021417059	PRKACB/VAMP2/CD38/PRKCA/ADRB1/ATP1A1/CALM1/PRH1/ITPR1/PLCB2/ADCY7/ITPR3/CALM2/PLCB1/AMY2B/ADRB2/ADCY3/GNAS/ITPR2	-0.0827325685543878
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/1948	49/9376	0.982273813015966	PRKACB/GNAI3/NFKB1/ATF2/ATF6B/CREB1/RGS9/RELA/FOSB/GNAS	-0.0637069105656788
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/1948	250/9376	0.98188090349076	VPS13C/GNPTAB/IDS/CD164/GGA2/ATP6V0E2/CTSC/VPS26A/AP1G1/OSBPL3/ATP6V1H/OSTM1/VPS13A/M6PR/SLC15A4/LAMP3/BLOC1S2/VAMP7/ATP6V1G1/STX17/OSBPL7/DMXL1/NEU1/MFSD8/DTNBP1/ABCA5/BLOC1S6/MANBA/TCIRG1/VPS29/AP3M2/MAN2B1/SPG11/AP3B1/BLOC1S4/AP3M1/PLEKHM1/BLOC1S5/ENTPD4/ATP6V0A2/RRAGB/CLN3/LAPTM5/WDR7/LAMTOR3/SLC36A4/AP1G2/TFEB/CTBS/ABCA2/TTI1	-0.148699831799032
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1948	65/9376	0.962628336755647	PRKACB/ORAI1/ATF2/ATF6B/CREB1/ITPR1/PLCB2/ADCY7/ITPR3/PLCB1/ADCY3/GNAS/ITPR2	-0.154826433135881
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1948	30/9376	0.962628336755647	PIGS/PIGG/PGAP1/PIGC/PIGF/PIGH	-0.104986711548483
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1948	30/9376	0.962628336755647	NFKB1/IKBKB/RELA/ABCC1/CHUK/ABCC5	-0.104986711548483
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1948	20/9376	0.962628336755647	UGP2/CYB5R4/UAP1/TGDS	-0.0856754679093643
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1948	31/9376	0.931575809763529	PGP/DLD/CAT/ACAT2/MDH1/GLYCTK	-0.195409209322749
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1948	21/9376	0.916788892148235	CSGALNACT2/CHST12/CHST11/B3GALT6	-0.195484902727132
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1948	42/9376	0.916788892148235	DLD/CAT/GCDH/ALDH9A1/HADH/ACAT2/DLST/ALDH3A2	-0.276768218313702
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/1948	138/9376	0.941701633782698	CYCS/ATP6V0E2/NDUFV2/NDUFB8/SDHD/COX11/ATP6V1H/NDUFA5/ATP5F1C/SDHA/NDUFB5/ATP6V1G1/UQCRFS1/UQCRH/NDUFC2/UQCRC2/NDUFB3/TCIRG1/NDUFAB1/ATP5MC3/COX7A2L/COX7A2/NDUFA7/COX10/ATP6V0A2/NDUFA8/NDUFA9	-0.35330608325985
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1948	37/9376	0.910594372606693	UGP2/PGM2/GALT/GALK2/UAP1/TGDS/UXS1	-0.279035652245551
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	29/1948	149/9376	0.936785965299119	PRKACB/GNG2/MAPK1/GNAI3/NDUFV2/NDUFB8/PRKCA/NDUFA5/NDUFB5/NDUFC2/MAPK13/NDUFB3/MAPK8/ITPR1/GNG5/GNB5/NDUFAB1/PLCB2/ADCY7/ITPR3/NDUFA7/PLCB1/GNGT2/ADCY3/NDUFA8/PTGS2/ITPR2/NDUFA9/MAPK9	-0.398309395940655
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1948	134/9376	0.933893162524135	PRKACB/PPP1CB/ARHGEF1/MAPK1/PPP1CC/PRKCA/PRKCH/GNA13/PRKCQ/MAP2K2/CALM1/ROCK1/ITPR1/MAP2K1/PPP1R12A/PLCB2/BRAF/ADCY7/ITPR3/CALM2/PLCB1/ARHGEF12/RAF1/ADCY3/GNAS/ITPR2	-0.394693491755972
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1948	22/9376	0.875116669777861	CARNMT1/CNDP2/ALDH9A1/ALDH3A2	-0.300304123766115
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	44/1948	226/9376	0.93707183224001	PRKACB/RAC2/PPP1CB/ORAI1/MAPK1/GNAI3/NFKB1/PDE4B/RAP1A/PPP1CC/PTGER2/RAP1B/EP300/PIK3CD/VAV3/CAMK4/ADRB1/VAV1/MAP2K2/CAMK2D/PIK3CA/ATP1A1/CALM1/ATP2A2/ACOX1/ROCK1/MAPK8/CREB1/AKT1/RELA/MAP2K1/PPP1R12A/BRAF/ADCY7/PIK3R1/CALM2/NFATC1/RRAS2/PDE3B/ADRB2/RAF1/ADCY3/GNAS/MAPK9	-0.490380199888316
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1948	28/9376	0.85948958638897	B3GNT2/B4GALT1/B4GALT4/B3GNT5/B4GALT3	-0.381304861962172
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1948	39/9376	0.863897225293529	MAT2A/MTHFD2/MTHFS/DLD/MAT2B/MTHFD1/DMGDH	-0.436153910076243
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1948	86/9376	0.895468220237811	PRKACB/VAMP2/PRKCA/CAMK2D/ATF2/ATP1A1/ATF6B/CREB1/PLCB2/ADCY7/ITPR3/PLCB1/ADCY3/GNAS/STX1A/KCNN1	-0.498693698308942
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1948	23/9376	0.837068118917954	GLS/ATP1A1/GLUD1/MDH1	-0.400625592662469
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1948	50/9376	0.866365503080082	AMD1/ODC1/LAP3/CNDP2/OAT/SAT2/ALDH9A1/ARG2/ALDH3A2	-0.48517682327478
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1948	18/9376	0.802190280629706	ACSL3/ACACA/ACSF3	-0.430166440559322
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	27/1948	144/9376	0.902464065708419	JARID2/KRAS/STAT3/CTNNB1/MAPK1/JAK3/SKIL/KAT6A/PCGF5/PIK3CD/JAK1/SMARCAD1/MAP2K2/PIK3CA/RIF1/TCF3/MAPK13/ID2/TCF7/SMAD4/AKT1/MAP2K1/PIK3R1/APC/AXIN1/RAF1/SETDB1	-0.604007266588707
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/1948	67/9376	0.862055226945355	BPGM/PFKP/PDHA1/DLD/PGK1/LDHB/PGM2/ALDH9A1/ALDH3A2/PDHB/LDHA/ADPGK	-0.580276926585467
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	21/1948	115/9376	0.878921524863851	CASP3/PRKACB/GNG2/KRAS/MAPK1/GNAI3/PRKCA/DUSP1/ITPR1/GNG5/GNB5/MAP2K1/PLCB2/BRAF/ITPR3/PLCB1/GNGT2/RAF1/GNAS/PTGS2/ITPR2	-0.66900765606151
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1948	52/9376	0.833043752961617	MYLIP/VAPA/VDAC3/VDAC2/CIDEB/STARD3/LDLRAP1/STARD3NL/VAPB	-0.618226162843979
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1948	36/9376	0.802190280629706	UGP2/PGM2/AMY2B/PYGB/GYG1/PGM2L1	-0.608933133969807
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1948	48/9376	0.802190280629706	PDCD6IP/CHMP7/IST1/VPS4A/TSG101/CHMP4A/OCLN/DPP4	-0.703587546336406
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1948	48/9376	0.802190280629706	PIK3CD/PIK3CA/ATP1A1/AKT1/PLCB2/PIK3R1/PLCB1/AMY2B	-0.703587546336406
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1948	91/9376	0.846266669675294	PRKACB/GNG2/PDE7A/GNAI3/PDE4B/PRKCA/ARRB2/GRK2/GNG5/GNB5/GRK6/ADCY7/GNGT2/PDE3B/ADCY3/GNAS	-0.754643689039518
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1948	37/9376	0.780509462234308	PRKCA/FASLG/IFNG/FAS/PLCB2/PLCB1	-0.685031660230386
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1948	54/9376	0.802190280629706	PRF1/CTLA4/HLA-F/HLA-B/FASLG/GZMB/FAS/HLA-A/CD28	-0.746507412382174
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1948	32/9376	0.752053388090349	PFKP/UGP2/B4GALT1/PGM2/GALT	-0.719467067263627
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1948	38/9376	0.759969739543932	UGP2/PGM2/GALT/GALK2/UAP1/UXS1	-0.759232913334548
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1948	15/9376	0.641752224503764	ACP1/NTPCR	-0.711069705358697
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/1948	89/9376	0.811203654569365	GLS/PRKACB/GNG2/SLC38A1/GNAI3/SLC38A2/PRKCA/GABARAPL2/NSF/GNG5/GNB5/GABARAPL1/ADCY7/GNGT2/ADCY3	-0.916420996227106
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1948	28/9376	0.687591669111176	ATP6V0E2/ATP6V1G1/TCIRG1/ATP6V0A2	-0.847786384112136
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1948	154/9376	0.84386250300008	GCH1/MAT2A/MTHFD2/UGP2/DLD/ALAS1/CTPS1/PANK3/RDH11/CMPK1/PPCS/GGCX/PHOSPHO2/MAT2B/PANK2/FLAD1/MTHFD1/PDXK/COX10/MOCS2/NADSYN1/NME3/ALDH3A2/ADSL/PSAT1/CMPK2/DHODH	-1.00045873739111
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1948	102/9376	0.802190280629706	CD38/RAP1A/RAP1B/PRKCA/RAB8A/ATP1A1/ATP2A2/ITPR1/PLCB2/ADCY7/ITPR3/PLCB1/AMY2B/RAB27B/ADCY3/GNAS/ITPR2	-1.02862798082448
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1948	29/9376	0.663881611555619	MOB1A/RASSF1/LATS1/MOB1B	-0.92832344149057
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1948	41/9376	0.704362197626083	BPGM/DLD/ALAS1/GLYCTK/PSAT1/DMGDH	-0.971491263599099
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1948	23/9376	0.627801089188465	GLS/GLUD1/ARG2	-0.915182518251963
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1948	23/9376	0.627801089188465	B4GALT1/B4GALT3/POMGNT1	-0.915182518251963
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1948	59/9376	0.734208053457697	ODC1/LAP3/TXNDC12/GSR/IDH1/G6PD/GSTM2/GSTM4/GGCT	-1.04875475463709
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1948	17/9376	0.566251962797439	SCP2/ACOT8	-0.916624427007972
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1948	17/9376	0.566251962797439	SEPHS2/PAPSS1	-0.916624427007972
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1948	17/9376	0.566251962797439	CA5B/GLUD1	-0.916624427007972
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1948	17/9376	0.566251962797439	PCDH9/PCDH11X	-0.916624427007972
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1948	10/9376	0.481314168377823	PAPSS1	-0.840371809048621
NA	NA	hsa04981	Folate transport and metabolism	4/1948	31/9376	0.621050539842353	MTHFS/ABCC1/MTHFD1/ABCC5	-1.08222273623954
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1948	50/9376	0.673839835728953	CXCR4/ITGA4/ICOS/ITGB7/TGFB1/CD28/MAP3K14	-1.18416543652376
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	33/1948	195/9376	0.81453166956247	RAC2/PLCG2/CASP4/MAPK1/CASP1/NFKB1/HAT1/PIK3CD/VDAC3/PRKCA/SLC25A5/SELPLG/VDAC2/MAP2K2/PIK3CA/MAPK13/NCF4/HMGB1/GSDMD/AKT1/PLCG1/RELA/HDAC1/MAP2K1/HDAC3/PLCB2/PIK3R1/HDAC9/PLCB1/MAP3K7/HDAC8/RAF1/HDAC10	-1.34025131325093
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/1948	103/9376	0.747672494567493	CASP3/PRKACB/NFKB1/PIK3CD/PRKCA/PIK3CA/RAB5A/IFNG/RELA/TGFB1/PLCB2/SERPINB9/ARG2/PIK3R1/PLCB1/GNAS	-1.31861266756374
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1948	75/9376	0.705927446954141	MAT2A/PFKP/PGK1/IDH3A/TKT/RPIA/MAT2B/IDH1/TALDO1/ARG2/PSAT1	-1.30937627766511
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1948	12/9376	0.401095140314853	GGCX	-1.06307015193822
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1948	53/9376	0.635697958234861	PRKACB/PRKCA/DNM2/ATP1A1/PLCB2/PLCB1/GNAS	-1.36196474212675
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1948	100/9376	0.721971252566735	CXCR4/IL10RA/IL18R1/XCL1/IL2RB/IL18RAP/XCL2/TNFRSF10A/CCR5/CCR7/IL10RB/CSF1/CCL5/IL2RG/CCR2	-1.43137523866005
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1948	29/9376	0.497911208666714	CALM1/RGS9/CALM2	-1.38671614148086
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	55/1948	323/9376	0.819575209312083	GLS/CASP3/SOCS1/EZH2/ATM/CDKN1B/BCL2L11/PIM1/KRAS/STAT3/PLCG2/CCND2/MCL1/MDM4/MAPK1/NFKB1/MDM2/PTEN/SOS2/SIRT1/ZEB2/PDCD4/BCL2/EP300/HNRNPK/PIK3CD/DNMT3A/PRKCA/RASSF1/UBE2I/ABCB1/MAP2K2/CCNG1/SOS1/PIK3CA/IKBKB/ROCK1/PLCG1/ABCC1/HDAC1/MAP2K1/EZR/BMF/RPS6KA5/BAK1/CD44/DNMT1/PIK3R1/APC/STMN1/E2F3/CRKL/DDIT4/RAF1/PTGS2	-1.6898391907878
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1948	37/9376	0.520339641489539	GLS/GLUD1/PPAT/ADSL	-1.49702367620006
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1948	63/9376	0.61119259476549	CTNNB1/LEF1/GADD45A/TCF7/BAK1/APC/AXIN1/PTCH2	-1.58563844878219
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1948	23/9376	0.418534059458977	LNPEP/PREP	-1.42973944384146
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1948	51/9376	0.566251962797439	PAFAH1B1/AGPS/SELENOI/LPCAT4/CEPT1/PAFAH1B2	-1.59053180279587
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1948	82/9376	0.645665347823909	UPP1/HPRT1/DPYD/CMPK1/GMPS/DUT/CDADC1/UCKL1/NME3/GSTM2/GSTM4	-1.65030184545077
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1948	76/9376	0.63330811628661	HMGCS1/ACSL3/DBI/ACADM/ACOX1/FABP5/SCP2/PPARD/PDPK1/SLC27A2	-1.64365545824283
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/1948	100/9376	0.673839835728953	ITGA4/CD38/CD7/CD2/CD55/CD8B/KIT/CD8A/IL4R/CD37/CD3G/CD3E/CD44/CSF1	-1.67917018396427
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1948	15/9376	0.320876112251882	ST6GALNAC6	-1.34796209716641
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/1948	191/9376	0.755990840384016	PRKACB/GNG2/PPP1CB/KRAS/MAPK1/GNAI3/HAT1/SOS2/PPP1CC/CAMK4/ATF2/SOS1/CALM1/ATF6B/CREB1/GNG5/GNB5/HDAC1/MAP2K1/HDAC3/PKIA/BRAF/FOSB/CALM2/HDAC9/GNGT2/HDAC8/RAF1/GNAS/HDAC10	-1.74472666863332
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1948	95/9376	0.658640440938074	CTLA4/ATP6V0E2/ATP6V1H/ATP6V1G1/IFNG/IL23A/TCIRG1/TGFB1/TNFSF11/CSF1/CD28/CCL5/ATP6V0A2	-1.71246085238836
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1948	52/9376	0.555362501974412	PRKACB/HSD17B7/ADCY7/ADCY3/GNAS/PTGS2	-1.64645851315591
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/1948	194/9376	0.744300260378077	BICDL1/DYNLT1/KIF2A/CAPZA1/MYL12A/TUBA1A/DYNLT3/TUBA4A/MYO9B/CAPZA2/DCTN4/MYL12B/MYO7A/DYNLL2/MYO1F/STARD9/KIF20B/TUBD1/MYO1G/TUBB2A/DCTN6/KIF18A/KIF13B/ACTR10/KLC1/KIF3A/TUBE1/KIF11/DYNLL1/KIF5C	-1.84292080751773
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1948	79/9376	0.609258440984587	VAMP2/ATP6V0E2/ATP6V1H/ATP6V1G1/DNM2/NSF/TCIRG1/STX3/ATP6V0A2/STX1A	-1.78597716598192
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1948	26/9376	0.370241667982941	LMBRD1/ABCC1	-1.64664112452747
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1948	254/9376	0.757975068311533	CXCR4/PRKACB/PLCG2/ORAI1/PPP3CA/STIM2/CD38/PPP3CC/VDAC3/CAMK4/PRKCA/SLC25A5/ADRB1/VDAC2/STIM1/CAMK2D/PPP3R1/CALM1/PHKB/SPHK2/ATP2A2/ITPR1/PLCG1/NFATC3/PLCB2/ADCY7/ITPR3/PPP3CB/CALM2/NFATC1/CYSLTR1/PLCB1/NFATC2/ADRB2/MCU/ADCY3/GNAS/TFEB/ITPR2/P2RX5	-2.00251647377693
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1948	35/9376	0.412555001466706	PFKP/PFKFB3/TIGAR	-1.78298920458696
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1948	50/9376	0.481314168377823	GYPC/IFNG/KLRK1/TGFB1/KLRB1	-1.88315404977273
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/1948	155/9376	0.683155593826588	TAP1/CALR/SEC22B/ATP6V0E2/HLA-F/HLA-B/TUBA1A/ATP6V1H/M6PR/TUBA4A/TAP2/ATP6V1G1/STX12/NCF4/SEC61B/RAB5A/PIK3C3/TCIRG1/TUBB2A/HLA-A/CORO1A/ATP6V0A2	-2.03688752886
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1948	28/9376	0.343795834555588	GCH1/MOCS2	-1.78074942841206
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1948	19/9376	0.253323246514644	IDS	-1.66834276840263
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/1948	160/9376	0.661806981519507	PTPRC/NCAM1/ITGA4/CTLA4/CD58/HLA-F/CD2/HLA-B/SELL/SELPLG/TIGIT/ICOS/ICAM3/ITGB7/CD8B/SPN/OCLN/CD8A/CD226/HLA-A/CD28/CD99	-2.20951809796858
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1948	61/9376	0.473423772174908	TRPM7/MT2A/MT1X/ATP1A1/MT1F/ATP7A	-2.11289980925076
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1948	31/9376	0.310525269921176	ALDH9A1/ALDH3A2	-1.96903626315634
NA	NA	hsa04518	Integrin signaling	20/1948	154/9376	0.625083335555615	RAC2/ITGA4/CCND3/CTNNB1/CCND2/CDC42/ITGAE/ARHGEF6/PIK3CD/FERMT3/PARVG/ICAM3/PIK3CA/ITGB7/ITGAX/AKT1/TGFB1/NCK2/PIK3R1/COL9A2	-2.40229707753742
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1948	24/9376	0.200547570157426	B3GALT6	-2.00812233046417
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1948	26/9376	0.185120833991471	ACOX1	-2.13068010068653
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1948	105/9376	0.504233890681529	PRKACB/ITGA4/ADRB1/ATP2A2/ITGB7/TGFB1/SNTB1/ADCY7/SNTB2/ADCY3/GNAS	-2.61608807356322
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1948	63/9376	0.381995371728431	PTGES3/PTGES2/LTA4H/EPHX2/PTGS2	-2.52035297404302
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/1948	86/9376	0.447734110118905	ITGA4/CTNNB1/LEF1/TCF7/ATP2A2/ITGB7/SNTB1/SNTB2	-2.63471567882271
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1948	90/9376	0.427834816335843	PRKACB/ABCB1/ATP1A1/HMGCR/ADCY7/SLC51A/ADCY3/GNAS	-2.7930101205489
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1948	43/9376	0.223867055059453	ACAT2/AGPAT2	-2.61218469389524
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1948	87/9376	0.387264273407444	UQCRFS1/UQCRH/ATP1A1/UQCRC2/ATP2A2/COX7A2L/COX7A2	-2.94030589853249
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/1948	298/9376	0.646059286413186	CXCR4/IFNGR1/IL10RA/IL18R1/TNFRSF9/XCL1/IL2RB/IL16/RELT/IL27RA/TGFBR2/IL18RAP/XCL2/TNFRSF10A/FASLG/CCR5/TNFRSF18/TNFSF9/IFNG/TNFSF12/FAS/IL23A/IL4R/TNFSF4/TGFB1/IL12RB2/CCR7/IL10RB/TNFSF11/CD27/CSF1/CXCR6/CCL5/TNFRSF25/IL21R/IL2RG/TNFSF8/OSM/CCR2/IL26	-3.17971160494718
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1948	46/9376	0.209267029729488	ALAS1/COX10	-2.75303738116357
NA	NA	hsa04519	Cadherin signaling	58/1948	404/9376	0.690995588265192	KRT81/MOB1A/EVL/RAC2/PPP1CB/SHOC2/KRAS/CTNNB1/CSNK1A1/CDC42/LEF1/MAPK1/KRT86/NFKB1/PPP1CC/ARPC5L/EP300/ACTR2/NCKAP1L/VAV3/ERBIN/ACTR3/TMC6/VASP/VAV1/ADAM10/YWHAZ/MAP2K2/ARPC1B/PCDH9/KRT10/MAPK13/MYO7A/TCF7/IKBKB/CYFIP2/MYO1F/TMC8/ROCK1/MAPK8/LATS1/PCDH11X/RELA/MYO1G/RYK/MAP2K1/YWHAB/ARPC3/MAP2K3/APC/RRAS2/PSEN1/CHUK/AXIN1/RAF1/ACTR3C/MOB1B/MAPK9	-3.25128392676483
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1948	36/9376	0.133698380104951	UGP2	-2.66680404807769
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1948	99/9376	0.388940742123494	ITGA4/PRKAA1/ATP2A2/ITGB7/TGFB1/SNTB1/SNTB2/PRKAG2	-3.12997821066688
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1948	66/9376	0.218779167444465	HSD17B7/HSD17B11/HSD17B12	-3.26148293245373
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1948	86/9376	0.279833818824316	PRKACB/PLCB2/ITPR3/PLCB1/TAS2R4	-3.43572392151537
NA	NA	hsa04081	Hormone signaling	23/1948	219/9376	0.505489765876253	PRKACB/GNG2/STAT3/GNAI3/PIK3CD/ADRB1/GNA13/PIK3CA/SMAD4/ADIPOR2/GNG5/GNB5/PLCB2/ADCY7/STAT5B/PIK3R1/PLCB1/GNGT2/STK11/ADRB2/GNRH1/ADCY3/GNAS	-3.79197007371002
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1948	70/9376	0.206277500733353	GSTM2/GSTM4/PTGS2	-3.41334631834273
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1948	89/9376	0.270401218189788	ITGA4/CD47/ITGB7/CD44/COL9A2	-3.54148614978489
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/1948	103/9376	0.28037718546281	SLC38A2/SLC3A2/ATP1A1/DPP4/COL9A2/SLC36A4	-3.76060373398502
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1948	73/9376	0.131866895445979	GSTM2/GSTM4	-3.81311939559675
NA	NA	hsa04082	Neuroactive ligand signaling	17/1948	199/9376	0.411172907659447	PRKACB/GNG2/GNAI3/PRKCA/ADRB1/OGFR/GNG5/GNB5/PLCB2/ADCY7/PLCB1/GNGT2/ADRB2/ADCY3/GNAS/P2RY11/P2RX5	-4.29940268427838
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/1948	88/9376	0.164084375583349	CD46/CD55/ITGAX	-4.03447327074255
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/1948	233/9376	0.433802469353403	LBR/ITGA4/SPTAN1/SYNE1/LMNB1/CAPZA1/TMOD3/DIAPH1/LMOD3/CAPZA2/SYNE3/ATP1A1/TMEM43/ITGB7/FMNL1/FMNL3/SNTB1/SNTB2/COL9A2/AMPD2/SYNE2	-4.48173051000568
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/1948	79/9376	0.121851688196917	GSTM2/GSTM4	-4.01378557524773
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1948	68/9376	0.0707814953496799	RDH11	-3.93811401763678
NA	NA	hsa04382	Cornified envelope formation	17/1948	217/9376	0.37706639919	KRT81/PPP2R5C/PPP2R5A/KRT86/PPP2R2A/PPP2CA/UGCG/PPP2R3C/KRT10/SPTLC2/PPP2R2D/PPP2R2B/SPTLC1/OCLN/BLMH/ABHD5/EPHX2	-4.75435669545194
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1948	99/9376	0.0972351855308734	SELPLG/KRT10	-4.62415741554176
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/1948	143/9376	0.168291667264973	SSB/TRIM21/IFNG/SNRPB/CD28	-5.13229747235542
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/1948	370/9376	0.260169820744769	GZMA/PTGER4/PTGER2/P2RY10/ADRB1/S1PR4/OGFR/PTGDR/LPAR6/CYSLTR1/S1PR5/LPAR2/ADRB2/S1PR1/INSL3/GNRH1/NR3C1/P2RY11/CNR2/P2RX5	-7.43551579980655
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1948	449/9376	0.10719691946054	PRKACB/OR11G2/NCALD/ARRB2/CAMK2D/CALM1/OR2A25/GRK2/CALM2/ADCY3	-9.92819389302663