category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	73/2075	122/9376	2.70372506419119	ITK/PTPRC/PPP2R5C/LCK/KRAS/MALT1/PPP2R5A/CD247/CDC42/PPP3CA/BCL10/NFKB1/MAPK1/PPP3CC/CARD11/CBLB/CTLA4/SOS2/NCK1/PPP2R2A/LCP2/PPP2R3C/VAV3/PPP2CA/PIK3CD/ICOS/PRKCQ/MAP3K8/ZAP70/LAT/PIK3CA/VAV1/MAP2K2/TEC1/SOS1/IKBKB/RASGRP1/PAK2/GRAP2/MAPK13/PPP3R1/PPP2R2D/CD28/MAP2K1/MAPK8/NFATC3/NCK2/PLCG1/GRB2/IFNG/CD3G/PPP2R2B/AKT1/CD3E/PPP3CB/CD8B/CD8A/MAP3K7/RELA/RAF1/NFKBIE/PDCD1/MAP3K14/DLG1/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/FYN/JUN/PDPK1/CD40LG	10.0976007431085
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	63/2075	108/9376	2.63582329317269	DDX39B/NUP98/PNN/THOC3/XPO1/EIF4A3/SUMO1/KPNA4/NUP58/RANBP2/NUP153/ACIN1/MAGOH/RNPS1/PHAX/SUMO4/NUP54/KPNA2/NXT1/NUP50/RAN/RBM8A/UBE2I/SENP2/NUP205/NUP88/SUMO2/NUP107/NUP210/NCBP1/NCBP2/SAP18/KPNA5/NMD3/AHCTF1/TNPO1/NXF1/THOC7/THOC1/IPO8/TMEM33/TPR/XPO4/UPF1/KPNA1/ALYREF/POM121C/XPOT/SRRM1/IPO7/NUP160/MAGOHB/UPF3B/NUP43/NUP62/NUP188/RANBP17/SEH1L/KPNA3/NUP133/XPO5/XPO7/THOC5	9.11504396373599
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	74/2075	142/9376	2.35473952146615	SOCS1/CUL3/UBE2B/UBE2A/UBE2D3/BIRC6/FBXW7/UBE2S/CBLB/TRIP12/UBA2/MDM2/UBA6/BIRC2/VHL/UBE2N/RNF7/HUWE1/HERC1/ITCH/HERC4/UBE4A/UBB/UBE2I/ANAPC5/UBE2D2/CBL/UBE3A/ANAPC4/UBE2G1/SKP1/CUL5/CUL2/UBE2H/ANAPC16/HERC2/RCHY1/ANAPC1/TRAF6/CUL1/UBE2J1/UBA3/UBE2L6/UBE3C/UBR5/SIAH1/CDC26/ANAPC10/UBE2Q1/UBE2Z/BIRC3/MAP3K1/SAE1/PIAS1/DDB2/UBE2M/BTRC/PPIL2/UBE2Q2/UBE2E3/PML/WWP2/WWP1/SMURF2/CDC23/HERC3/SOCS3/CDC27/COP1/UBE2F/CUL4B/UBE2J2/PIAS3/UBC	8.67178600426296
Human Diseases	Infectious disease: viral	hsa05162	Measles	70/2075	136/9376	2.32572643515237	HSPA1A/CASP3/CASP8/HSPA1B/MX1/HSPA8/ADAR/IRF7/OAS2/EIF2AK2/CDKN1B/OAS1/HSPA6/CYCS/CCND3/IRF9/STAT3/STAT1/CCND2/NFKB1/CBLB/JAK3/IL2RB/OAS3/MSN/BCL2/RAB9A/MX2/STAT2/TBK1/PIK3CD/CD46/EIF3H/JAK1/TRAF3/SLAMF1/PIK3CA/EIF2S1/CSNK2A1/RCHY1/TRAF6/IRF3/IKBKB/FAS/IFIH1/FASLG/APAF1/CD28/IKBKE/MAPK8/BBC3/CD3G/AKT1/BID/STAT5B/CD3E/IL2RG/MAP3K7/RELA/BAK1/TYK2/IRAK4/TNFAIP3/MAPK9/CHUK/IL2RA/PIK3R1/CSNK2A2/CDK6/JUN	8.3021561852568
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	92/2075	214/9376	1.94255601846639	CASP3/CASP8/APOBEC3G/CXCR4/ATM/BST2/CYCS/RAC2/GNG2/CGAS/TAP1/KRAS/B2M/PLCG2/CD247/TRAF5/PPP3CA/GNAI3/CALR/NFKB1/MAPK1/PPP3CC/RPS6KB1/SAMHD1/HLA-F/BCL2/RNF7/AP1G1/HLA-B/TBK1/PRKCA/PIK3CD/ATR/APOBEC3C/PIK3CA/APOBEC3D/TAP2/TRIM5/SKP1/CUL5/MAP2K2/TRAF6/IRF3/CALM1/IKBKB/CUL1/CCR5/FAS/PAK2/MAPK13/FASLG/PPP3R1/HLA-A/MAP2K1/MAPK8/ITPR1/NFATC3/PLCG1/PDIA3/GNG5/CD3G/MAP2K6/AKT1/BID/CD3E/PPP3CB/GNB5/MAP2K3/MAP3K7/RELA/BAK1/RAF1/CRKL/IRAK4/CALM2/BTRC/ITPR3/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/GNG10/GNGT2/JUN/ITPR2/AP1G2/DCAF1/CUL4B/TAB1/APOBEC3H/MTOR	7.43570973965355
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	50/2075	90/9376	2.51030789825971	LCK/KRAS/IFNGR1/STAT3/HIF1A/CD247/PPP3CA/STAT1/PTEN/NFKB1/MAPK1/PPP3CC/RPS6KB1/BATF/PIK3CD/PRKCQ/ZAP70/LAT/JAK1/PIK3CA/CSNK2A1/MAP2K2/TRAF6/IKBKB/RASGRP1/EML4/MAPK13/PPP3R1/CD28/MAP2K1/NFATC3/PLCG1/IFNG/CD3G/MAP2K6/AKT1/CD3E/PPP3CB/MAP2K3/RELA/RAF1/NFKBIE/PDCD1/CHUK/NFATC1/NFATC2/PIK3R1/CSNK2A2/JUN/MTOR	7.67495650819043
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	103/2075	250/9376	1.8616443373494	HSPA1A/HSPA1B/HSPA8/ARAP2/CXCR4/WIPF1/HSPA6/SMAP2/CDC42/ARF6/EPS15/CHMP5/PDCD6IP/CBLB/ARFGAP2/IL2RB/CAPZA1/ARPC5L/ARFGAP3/STAM/MDM2/VPS36/HLA-F/ACAP1/RAB8A/ACTR2/ACTR3/VPS26A/ITCH/SNX1/CHMP7/SH3GLB1/HLA-B/SH3KBP1/AGAP2/ARFGEF1/BIN1/SNX3/VPS37B/ARF4/ARPC1B/CAPZA2/SMAP1/CBL/ARRB2/IST1/EHD1/TGFBR2/CYTH4/RAB11FIP1/DNM2/TRAF6/CCR5/RAB11FIP4/RAB11FIP2/RUFY1/RAB5A/SNX6/VPS45/ACAP2/EPS15L1/VPS4A/GBF1/STAMBP/HLA-A/PSD4/GRK2/ARF1/TSG101/RAB22A/PIP5K1A/CYTH1/IQSEC3/IGF2R/CHMP4A/VPS29/KIF5B/GRK6/ARPC3/GIT2/SNX5/ASAP1/WASHC1/ACTR3C/PARD6B/IL2RG/WIPF3/WASHC2C/CYTH2/EHD4/ZFYVE27/ZFYVE16/CHMP2B/WIPF2/PML/LDLRAP1/IL2RA/STAM2/WWP1/SMURF2/RAB4A/RBSN/KIF5C	7.36141539066647
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	73/2075	157/9376	2.10098380784284	ATM/PPP1CB/CCND3/KRAS/ETS1/TRPM7/PPP3CA/PPID/SIRT1/CCND2/PTEN/NFKB1/MAPK1/PPP3CC/HIPK1/RBBP4/MDM2/PPP1CC/HLA-F/KIR2DL4/ZFP36L2/VDAC3/HLA-B/RBL2/PIK3CD/VDAC2/GADD45A/CAPN2/ATR/SLC25A5/PIK3CA/HUS1/RASSF5/TGFBR2/MAP2K2/HIPK3/LIN54/RBL1/CALM1/MAPK13/NBN/PPP3R1/HLA-A/MAP2K1/RB1/ITPR1/NFATC3/RHEB/MAP2K6/AKT1/PPP3CB/TSC2/CDKN2B/E2F4/MRE11/MAP2K3/RELA/RAF1/E2F3/CALM2/BTRC/ITPR3/NFATC1/NFATC2/MCU/PIK3R1/RRAS2/CDK6/ITPR2/TSC1/RAD9A/RAD50/MTOR	7.41638667731169
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	88/2075	205/9376	1.93967205406994	CASP3/CASP8/PSMD12/IRF7/OAS2/EIF2AK2/CDKN1B/OAS1/BCL2L11/CYCS/TAP1/CCND3/B2M/IRF9/PLCG2/STAT3/CD247/TRAF5/STAT1/CCND2/CALR/NFKB1/CD58/JAK3/MDM2/OAS3/HLA-F/PSMD6/BCL2/PSMC6/PSMC4/STAT2/HLA-B/TBK1/PIK3CD/SIN3A/PSMD11/GADD45A/JAK1/TRAF3/PSMD13/PIK3CA/TAP2/CIR1/SNW1/TRAF6/IRF3/IKBKB/SAP30/FAS/MAPK13/APAF1/USP7/HLA-A/IKBKE/MAPK8/RB1/PSMC2/PDIA3/CD3G/NFKB2/MAP2K6/HDAC1/AKT1/BID/CD3E/CD44/RUNX3/MAP2K3/MAP3K7/RELA/BAK1/NFKBIE/TYK2/DDB2/E2F3/IRAK4/HLA-DQA2/MAP3K14/ISG15/TNFAIP3/MAPK9/CHUK/PIK3R1/CDK6/JUN/MAP2K4/TAB1	7.25184327060945
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	80/2075	180/9376	2.00824631860776	SRSF5/CASP3/CASP8/ZC3HAV1/SRSF7/SRSF6/SRSF2/IRF7/OAS2/EIF2AK2/BST2/OAS1/PPP1CB/CYCS/SP100/CGAS/TAP1/PILRB/SRSF3/B2M/IRF9/IFNGR1/TRAF5/STAT1/SRSF9/CALR/EIF2B1/NFKB1/PPP1CC/OAS3/HLA-F/BIRC2/SRSF4/BCL2/SRSF1/STAT2/HLA-B/TBK1/PIK3CD/JAK1/TRAF3/PIK3CA/EIF2S1/TAP2/TRAF6/SRSF8/IRF3/IKBKB/FAS/IFIH1/EIF2B5/FASLG/APAF1/HLA-A/IKBKE/NXF1/SRPK1/PDIA3/RHEB/IFNG/BIRC3/AKT1/BID/ALYREF/TSC2/MAP3K7/RELA/BAK1/TYK2/IRAK4/HLA-DQA2/HCFC1/PML/CHUK/PIK3R1/SOCS3/CCL5/TSC1/TAB1/MTOR	7.28126656454708
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	44/2075	78/9376	2.54892801977139	HSPD1/DDX6/CNOT2/BTG1/HSPA9/LSM8/BTG3/PNPT1/PAN3/PFKP/TOB1/CNOT4/XRN1/CNOT9/CNOT7/EXOSC6/BTG2/LSM1/DCP2/C1D/DCP1A/EXOSC1/EXOSC3/PATL1/EXOSC9/DIS3/MTREX/XRN2/CNOT6L/LSM2/EXOSC8/ZCCHC7/LSM5/LSM6/CNOT1/CNOT6/EXOSC2/DCPS/PARN/TENT4B/CNOT10/MPHOSPH6/EXOSC5/EXOSC7	7.32297043990767
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	84/2075	196/9376	1.93652323580034	CASP3/CASP8/CLEC2B/IRF7/EIF2AK2/CYCS/GNG2/CTNNB1/KRAS/IRF9/IFNGR1/PLCG2/STAT3/HIF1A/MAP1LC3B/PPP3CA/STAT1/NFKB1/LEF1/MAPK1/PPP3CC/EP300/HLA-F/ZFP36/PREX1/STAT2/HLA-B/TBK1/UBB/PIK3CD/PIK3CG/JAK1/ATG3/TRAF3/PIK3CA/MAP2K2/IRF3/CALM1/IKBKB/CCR5/FAS/MAPK13/PPP3R1/CREB1/HLA-A/TCF7/IKBKE/MAP2K1/MAPK8/RB1/ITPR1/NFATC3/PLCG1/GNG5/PIK3C3/MAP2K6/AKT1/BID/PPP3CB/GNB5/RELA/BAK1/RAF1/TYK2/E2F3/CALM2/ITPR3/MAPK9/CHUK/NFATC1/NFATC2/PIK3R6/PIK3R1/GNG10/CCR1/CCR4/GNGT2/CDK6/JUN/ITPR2/MAP2K4/MICB/UBC/MTOR	7.06364340516522
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	92/2075	224/9376	1.855834767642	ATM/PRKACB/BUB3/LCK/CCND3/KRAS/B2M/ELK4/XPO1/ETS1/PPP3CA/PTTG1/CCND2/PTEN/CALR/NFKB1/MAPK1/PPP3CC/TBPL1/JAK3/IL2RB/EP300/HLA-F/ZFP36/VDAC3/KAT2B/HLA-B/RAN/PIK3CD/VDAC2/ANAPC5/CDKN2C/ATR/JAK1/SLC25A5/PIK3CA/ATF2/ANAPC4/CRTC3/TGFBR2/TRRAP/MAD1L1/ANAPC16/MAP2K2/ANAPC1/IKBKB/ATF6B/PPP3R1/CREB1/HLA-A/MAP2K1/MAPK8/RB1/GPS2/NFATC3/SMAD4/TCF3/CDC26/RANBP1/ANAPC10/CD3G/NFKB2/AKT1/STAT5B/CD3E/PPP3CB/MAP3K1/CDKN2B/POLB/ADCY7/IL2RG/RELA/E2F3/ELK1/HLA-DQA2/MAP3K14/KAT2A/DLG1/MAPK9/CHUK/NFATC1/IL2RA/NFATC2/ADCY3/PIK3R1/MAD2L1/CDC23/CDC27/NFYB/JUN/MAP2K4/RANBP3	6.91129520140218
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	92/2075	227/9376	1.83130831696831	CASP3/CASP8/CXCR4/PRKACB/CYCS/RAC2/GNG2/CGAS/TAP1/CTNNB1/KRAS/B2M/IL10RA/STAT3/TRAF5/PPP3CA/ARHGEF1/GNAI3/CALR/NFKB1/PTGER4/MAPK1/PPP3CC/RPS6KB1/SOS2/MDM2/HLA-F/PTGER2/HLA-B/TBK1/PRKCA/PIK3CD/JAK1/PIK3CA/ATF2/GNA13/TAP2/MAP2K2/SOS1/IRF3/CALM1/IKBKB/CCR5/ATF6B/FAS/PLCB2/MAPK13/FASLG/PPP3R1/CREB1/ROCK1/HLA-A/MAP2K1/RB1/ITPR1/NFATC3/PDIA3/GNG5/RHEB/GRB2/MAP2K6/AKT1/BID/PPP3CB/TSC2/GNB5/ADCY7/IL10RB/RELA/BAK1/RAF1/CRKL/E2F3/ELK1/CALM2/ARHGEF12/ITPR3/CHUK/NFATC1/NFATC2/ADCY3/PIK3R1/GNG10/CCL5/CCR1/PLCB1/GNAS/GNGT2/CDK6/ITPR2/TSC1/MTOR	6.75914486912488
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	48/2075	93/9376	2.3321570151574	LCK/STAT4/IFNGR1/CD247/PPP3CA/STAT1/NFKB1/MAPK1/PPP3CC/JAK3/IL2RB/PRKCQ/ZAP70/LAT/JAK1/TBX21/MAML2/IKBKB/MAPK13/IL4R/PPP3R1/IL12RB2/MAPK8/GATA3/NFATC3/PLCG1/IFNG/CD3G/STAT5B/CD3E/PPP3CB/RUNX3/IL2RG/RELA/NFKBIE/TYK2/HLA-DQA2/IL12RB1/MAPK9/CHUK/NFATC1/IL2RA/NFATC2/MAF/JUN/DLL1/MAML3/NOTCH1	6.88265862957781
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	71/2075	163/9376	1.96820459753123	CASP3/CASP8/IRF7/DDX3X/CYCS/STAT4/KRAS/STAT3/STAT1/NFKB1/MAPK1/JAK3/SOS2/EP300/BCL2/STAT2/VDAC3/TBK1/PRKCA/PIK3CD/JAK1/TRAF3/PIK3CA/ATF2/TGFBR2/CASP10/YWHAZ/MAP2K2/SOS1/TRAF6/IRF3/IKBKB/ATF6B/FAS/IFIH1/MAPK13/FASLG/APAF1/CREB1/IKBKE/MAP2K1/MAPK8/RB1/NFATC3/SMAD4/GRB2/MAP2K6/AKT1/BID/STAT5B/YWHAB/MAP3K1/MAP2K3/MAP3K7/RELA/RAF1/TYK2/DDB2/E2F3/ELK1/IRAK4/BRAF/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/PCNA/JUN/MAP2K4/TAB1	6.64758534437258
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	53/2075	109/9376	2.1970951696695	LCK/HSP90AB1/HSP90AA1/IFNGR1/STAT3/HIF1A/CD247/PPP3CA/STAT1/NFKB1/MAPK1/PPP3CC/JAK3/IL2RB/IL27RA/PRKCQ/ZAP70/LAT/IRF4/JAK1/TBX21/TGFBR2/AHR/IKBKB/MAPK13/IL4R/PPP3R1/MAPK8/GATA3/NFATC3/SMAD4/PLCG1/IFNG/CD3G/STAT5B/CD3E/PPP3CB/IL23A/IL2RG/RELA/NFKBIE/TYK2/HLA-DQA2/IL12RB1/MAPK9/CHUK/NFATC1/IL2RA/NFATC2/JUN/IL21R/RARA/MTOR	6.70155923045618
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	62/2075	138/9376	2.03007508294046	WIPF1/RAC2/LCK/ITGA4/CDC42/WAS/ARF6/ARHGEF1/CASP1/NFKB1/MAPK1/ARPC5L/ACTR2/ACTR3/LCP2/VAV3/TBK1/PIK3CD/ZAP70/LAT/ARPC1B/PIK3CA/VAV1/PYCARD/PKN2/MAP2K2/TRAF6/IRF3/IKBKB/MAPK13/ROCK1/MAP2K1/MAPK8/NFATC3/PIP5K1A/PLCG1/MAP2K6/AKT1/RPS6KA3/ARPC3/GIT2/CD8B/CD8A/ACTR3C/MAP2K3/MAP3K7/RELA/ARHGEF7/SKAP2/CRKL/WIPF3/IRAK4/ARHGEF12/WIPF2/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/JUN/MAP2K4/TAB1	6.49864720186112
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	50/2075	103/9376	2.19347292080945	DDX39B/PAPOLA/SMG1/PPP1CB/PPP2R5C/PNN/PABPN1/EIF4A3/PPP2R5A/HBS1L/CPSF6/RNMT/WDR33/ACIN1/MAGOH/GSPT1/MSI2/RNPS1/FIP1L1/PPP1CC/PPP2R2A/ETF1/NXT1/PPP2R3C/PPP2CA/RBM8A/PAPOLG/CLP1/FUS/NCBP1/NCBP2/RNGTT/CSTF1/CSTF2T/SAP18/WDR82/PPP2R2D/NXF1/PELO/PPP2R2B/UPF1/ALYREF/SMG6/SRRM1/SMG7/NUDT21/MAGOHB/UPF3B/DAZAP1/CSTF3	6.49268848996194
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	43/2075	83/9376	2.34093772681086	OGT/EZH2/EED/JARID2/UBE2D3/KDM2A/MTF2/RYBP/PHC3/PHF1/EP300/RBBP4/CBX4/PCGF5/ASXL1/SUZ12/MBD5/MAX/AEBP2/UBE2D2/RBBP7/SKP1/ASXL2/L3MBTL2/YAF2/KDM2B/USP7/FBRS/TFDP1/EZH1/RNF2/PHF19/HDAC1/MGA/LCOR/FOXK1/AUTS2/HCFC1/FBRSL1/CBX6/PCGF6/CBX7/BCOR	6.54143758275495
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	61/2075	137/9376	2.01191100167092	CASP3/CASP8/PMAIP1/ATM/BCL2L11/CYCS/SPTAN1/KRAS/TRAF1/ERN1/CFLAR/NFKB1/PRF1/MAPK1/MCL1/LMNB1/CTSC/BIRC2/BCL2/DDIT3/PIK3CD/GADD45A/CAPN2/TUBA1A/PIK3CA/EIF2S1/CASP10/TUBA4A/MAP2K2/PARP1/IKBKB/TNFRSF10A/FAS/PARP4/FASLG/APAF1/CASP2/GZMB/MAP2K1/MAPK8/ITPR1/HTRA2/CASP7/BBC3/BIRC3/AKT1/BID/AIFM1/RELA/BAK1/RAF1/MAP3K14/ITPR3/MAPK9/EIF2AK3/CHUK/CASP6/PIK3R1/JUN/ITPR2/PDPK1	6.36053478677226
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	71/2075	169/9376	1.89832751122835	TANK/PRKACB/VMP1/CALCOCO2/KRAS/HIF1A/MAP1LC3B/ERN1/PTEN/CFLAR/BIRC6/MAPK1/NRBF2/RPS6KB1/RAB8A/BCL2/SUPT20H/OPTN/SH3GLB1/PPP2CA/TBK1/UBB/PIK3CD/PRKCQ/ATG16L1/TAX1BP1/ATG3/NBR1/ATG12/PIK3CA/EIF2S1/STX17/MAP2K2/ATG5/TRAF6/GABARAPL2/PLEKHM1/IGBP1/PRKAA1/MAP2K1/MAPK8/ITPR1/HMGB1/RHEB/PIK3C3/RUBCN/EPG5/AKT1/TSC2/MAP3K7/RAB39B/RAF1/RRAGB/GABARAPL1/ATG2A/STK11/MAPK9/EIF2AK3/RAB33B/PIK3R1/RRAS2/DAPK2/ATG10/DDIT4/WIPI2/TSC1/MTMR14/PDPK1/UBC/C9orf72/MTOR	6.28235531424678
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	76/2075	187/9376	1.83641775658785	CASP8/TANK/IRF7/OAS2/OAS1/TXNIP/HSP90AB1/HSP90AA1/IFI16/IRF9/TRPM7/TRAF5/CARD16/MAP1LC3B/GBP5/STAT1/CASP1/CASP4/SUGT1/NFKB1/MAPK1/PSTPIP1/GBP4/CARD8/RBCK1/OAS3/DNM1L/BIRC2/BCL2/GBP2/AIM2/ERBIN/STAT2/VDAC3/TBK1/VDAC2/ATG16L1/JAK1/TRAF3/ATG12/PYCARD/GPSM3/TRPV2/PKN2/NLRP1/ATG5/TP53BP1/TRAF6/IRF3/IKBKB/GABARAPL2/PLCB2/MAPK13/GBP1/NAMPT/IKBKE/MAPK8/ITPR1/GSDMD/BIRC3/GBP3/MAP3K7/RELA/TYK2/IRAK4/GABARAPL1/ITPR3/TNFAIP3/MAPK9/CHUK/MCU/CCL5/PLCB1/JUN/ITPR2/TAB1	6.15904583435488
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	94/2075	248/9376	1.71267780800622	CASP3/CASP8/PTPRC/DYNLT1/CYCS/HSP90AB1/HSP90AA1/CTNNB1/CDC42/ARF6/CASP1/KPNA4/CASP4/NFKB1/LEF1/MAPK1/ARPC5L/GCC2/MYL12A/BIRC2/RHOH/BCL2/ACTR2/ACTR3/RAB9A/NCKAP1L/PIK3CD/PIK3CG/TUBA1A/ARPC1B/DYNLT3/PIK3CA/M6PR/PYCARD/MLKL/SKP1/TUBA4A/ACBD3/CYTH4/DNM2/MAP2K2/EXOC2/DCTN4/TRAF6/IKBKB/TNFRSF10A/MAPK13/RAB5A/EXOC5/CYFIP2/MYL12B/PLEKHM1/TCF7/DYNLL2/MAP2K1/MAPK8/ABI1/ARF1/TUBB2A/CYTH1/CASP7/GSDMD/PIK3C3/MAP2K6/KIF5B/DCTN6/BIRC3/AKT1/KPNA1/ARPC3/ACTR3C/STX10/MAP2K3/KLC1/MAP3K7/FBXO22/RELA/BAK1/ACTR10/RAF1/IRAK4/CYTH2/MAPK9/CHUK/SNX9/EXOC4/DYNLL1/EXOC7/KPNA3/JUN/FYCO1/KIF5C/MAP2K4/TAB1	6.06365906614814
Genetic Information Processing	Transcription	hsa03040	Spliceosome	92/2075	243/9376	1.71072834548069	SRSF5/HSPA1A/BCAS2/TRA2A/DDX5/HSPA1B/HSPA8/DDX39B/SRSF7/SRSF6/SRSF2/HNRNPA3/HSPA6/SF3B1/HNRNPU/THOC3/SRSF3/WBP11/EIF4A3/SRSF10/LSM8/TRA2B/PHF5A/SRSF9/DHX15/SNRPA1/ACIN1/MAGOH/PRPF18/SF3B6/SRSF4/RBMXL1/HNRNPK/SRSF1/SNRPB2/U2SURP/HNRNPC/PRPF38A/CCDC12/AQR/SF1/SNRNP27/PRPF8/RBM8A/HNRNPA1/SNRNP70/SF3B2/BUD31/PLRG1/RBM22/SF3A3/SNW1/FUS/SNRNP40/PPIH/NCBP1/NCBP2/CDC40/CWC15/SRSF8/SYF2/SMNDC1/SF3A2/SF3A1/PRPF3/LSM2/DHX8/RBM17/CRNKL1/SF3B4/PRPF40A/CDC5L/THOC7/THOC1/SNRPF/LSM5/LSM6/BUD13/ALYREF/SNRPB/SLU7/SF3B3/SF3B5/MAGOHB/CHERP/USP39/SART1/GPKOW/DHX38/U2AF1L4/EFTUD2/THOC5	5.98416498906163
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	83/2075	216/9376	1.7362962962963	HSPA1A/HSPD1/CASP3/CASP8/HSPA1B/HSPA8/TANK/IRF7/HSPA5/HSPA6/CYCS/HSP90AB1/HSP90AA1/KRAS/STAT3/CDC42/PPP3CA/ARHGEF1/HSPA4/ERN1/CASP1/NFKB1/MAPK1/PPP3CC/RAP1A/RAP1B/BCL2/DDIT3/VAV3/XBP1/ABCG1/TBK1/PRKCA/PIK3CD/TRAF3/CAMK2D/PIK3CA/EIF2S1/VAV1/PYCARD/ERO1A/TRAF6/IRF3/CALM1/IKBKB/TNFRSF10A/NFE2L2/FAS/NCF4/PLCB2/MAPK13/FASLG/APAF1/PPP3R1/IKBKE/MAPK8/ITPR1/NFATC3/PLCG1/CASP7/MAP2K6/AKT1/BID/PPP3CB/MAP2K3/MAP3K7/RELA/IRAK4/CALM2/MAPK9/EIF2AK3/CHUK/NFATC1/CASP6/NFATC2/PIK3R1/CCL5/PLCB1/JUN/MAP2K4/TAB1/PDPK1/CD40LG	5.83626857478665
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	65/2075	158/9376	1.85889888668598	CCNH/CDC14A/ATM/CDKN1B/BUB3/PPP2R5C/CCND3/PPP2R5A/DBF4/PTTG1/CCND2/EP300/MDM2/STAG2/SMC3/PPP2CA/WAPL/ESCO1/RAD21/RBL2/MCM3/ANAPC5/GADD45A/CDKN2C/PDS5B/ATR/ANAPC4/SKP1/PRKDC/ORC4/YWHAZ/MAD1L1/ANAPC16/PDS5A/NDC80/ANAPC1/RBL1/CUL1/STAG1/ATRX/ORC2/CDKN2D/RB1/SMAD4/TFDP1/MAD2L1BP/NIPBL/CDC26/TFDP2/ANAPC10/DDX11/HDAC1/YWHAB/CDKN2B/E2F4/BUB1/E2F3/MAD2L1/HDAC8/CDC23/CDC27/ORC3/PCNA/CDK6/MCM6	5.80437878229951
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	57/2075	133/9376	1.93652323580034	KLRD1/KLRC1/CASP3/KLRC2/RAC2/LCK/SH2D1A/KRAS/IFNGR1/PLCG2/CD247/PPP3CA/PRF1/MAPK1/PPP3CC/LAT2/CD48/SOS2/KLRC3/KIR2DL4/LCP2/VAV3/HLA-B/PRKCA/PIK3CD/ZAP70/LAT/PIK3CA/VAV1/SH2D1B/MAP2K2/SOS1/TNFRSF10A/FAS/ULBP2/FASLG/NCR1/PPP3R1/GZMB/HLA-A/MAP2K1/PLCG1/GRB2/HCST/IFNG/BID/PPP3CB/KLRK1/RAF1/BRAF/CD244/NFATC1/NFATC2/PIK3R1/FYN/ULBP1/MICB	5.79884386530949
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	47/2075	105/9376	2.02259093516925	CASP8/IRF1/KRAS/MALT1/IRF9/PLCG2/PPP3CA/CYLD/STAT1/CASP1/BCL10/NFKB1/MAPK1/PPP3CC/CBLB/MDM2/STAT2/PIK3CD/PIK3CA/PYCARD/CALM1/IKBKB/MAPK13/PLK3/PPP3R1/IKBKE/MAPK8/ITPR1/NFATC3/NFKB2/AKT1/PPP3CB/IL23A/RELA/RAF1/CALM2/ARHGEF12/MAP3K14/ITPR3/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/RRAS2/JUN/ITPR2	5.61741891226965
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	41/2075	87/9376	2.12943359645478	CASP3/PMAIP1/BCL2L11/CYCS/RAC2/CTNNB1/KRAS/LEF1/MAPK1/RPS6KB1/SOS2/BCL2/PIK3CD/GADD45A/PIK3CA/TGFBR2/MAP2K2/SOS1/MLH1/TCF7/MAP2K1/MAPK8/RALGDS/SMAD4/GRB2/BBC3/AREG/AKT1/BAK1/RAF1/DDB2/APC/MSH2/BRAF/RALB/MAPK9/AXIN1/PIK3R1/MSH3/JUN/MTOR	5.64208158256942
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	68/2075	174/9376	1.76587176291372	HSPH1/HSPA1A/HSPA1B/HSPA8/HERPUD1/HSPA5/DNAJB1/HSPA6/DNAJA1/HSP90AB1/HSP90AA1/UBE2D3/DNAJB11/DNAJA2/ERN1/CALR/ERO1B/DERL1/NGLY1/UBQLN1/UFD1/BCL2/DDIT3/XBP1/SAR1A/STT3B/SAR1B/PPP1R15A/CAPN2/UBE2D2/MBTPS1/EIF2S1/UBE2G1/SKP1/ERO1A/MAN1A1/CUL1/UBE2J1/ATF6B/NFE2L2/MOGS/SEC23A/UBXN1/SEC61B/OSTC/MAPK8/TRAM1/SEC24B/PDIA3/RAD23B/EDEM1/HYOU1/DDOST/UBXN2A/DNAJC10/YOD1/DNAJB2/BAK1/SEC24A/SEC23B/DAD1/MAPK9/EIF2AK3/DERL2/UGGT1/FBXO6/RNF5/UBE2J2	5.43617065550586
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	36/2075	73/9376	2.22832810694834	APOBEC3G/MX1/CXCR4/BST2/MDFIC/XPO1/CPSF6/NELFCD/RANBP2/PDCD6IP/NUP153/ELL2/EP300/SAMHD1/CCNT2/PSIP1/MX2/KAT2B/RAN/APOBEC3C/APOBEC3D/TRIM5/CCNT1/CCR5/AFF4/MLLT3/VPS4A/TSG101/CDK9/CHMP4A/SUPT4H1/KAT2A/FURIN/NELFB/NELFA/APOBEC3H	5.61652664709449
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	62/2075	156/9376	1.79583565029348	CASP3/CASP8/MX1/IRF7/OAS2/EIF2AK2/OAS1/RSAD2/CYCS/CTNNB1/KRAS/IRF9/STAT3/STAT1/CFLAR/NFKB1/MAPK1/SOS2/OAS3/PPP2R2A/MX2/STAT2/PPP2CA/TBK1/PIK3CD/JAK1/TRAF3/PIK3CA/IFIT1/EIF2S1/YWHAZ/MAP2K2/SOS1/TRAF6/IRF3/IKBKB/FAS/FASLG/APAF1/OCLN/PPP2R2D/IKBKE/MAP2K1/RB1/GRB2/IFNG/PPP2R2B/AKT1/BID/YWHAB/PIAS1/RELA/BAK1/RAF1/TYK2/E2F3/EIF3E/BRAF/CHUK/PIK3R1/SOCS3/CDK6	5.34347452307689
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	67/2075	173/9376	1.74996030364231	CASP3/CASP8/MX1/ADAR/IRF7/OAS2/EIF2AK2/OAS1/DNAJB1/RSAD2/NUP98/CYCS/CALCOCO2/CCND3/IRF9/IFNGR1/PABPN1/XPO1/STAT1/CASP1/NFKB1/MAPK1/EP300/OAS3/KPNA2/NXT1/MX2/STAT2/TBK1/PRKCA/PIK3CD/JAK1/TRAF3/SLC25A5/PIK3CA/EIF2S1/HNRNPUL1/PYCARD/MAP2K2/IRF3/IKBKB/TNFRSF10A/FAS/IFIH1/FASLG/KPNA5/APAF1/IKBKE/MAP2K1/NXF1/IFNG/AKT1/BID/KPNA1/RELA/BAK1/RAF1/TYK2/IRAK4/HLA-DQA2/PML/CHUK/PIK3R1/SOCS3/CCL5/CDK6/TRIM25	5.30762378098608
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	50/2075	119/9376	1.89855219196112	CASP3/CASP8/IRF1/TRAF1/TRAF5/IL18R1/CYLD/CFLAR/NFKB1/MAPK1/DNM1L/BIRC2/ITCH/PIK3CD/MAP3K8/TRAF3/PIK3CA/ATF2/MLKL/CASP10/ADAM17/IKBKB/ATF6B/FAS/MAPK13/CREB1/MAP2K1/MAPK8/RPS6KA5/CASP7/MAP2K6/BIRC3/AKT1/CSF1/MAP2K3/MAP3K7/RELA/MAP3K14/CEBPB/TNFAIP3/MAPK9/CHUK/PIK3R1/SOCS3/CCL5/JUN/PGAM5/MAP2K4/FRMD8/TAB1	5.2587820430219
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	75/2075	205/9376	1.65312959153688	CASP3/CASP8/GTF2B/PMAIP1/IRF7/EIF2AK2/CDKN1B/PRKACB/GTF2H2/DDX3X/RASA2/SP100/CCND3/KRAS/IRF9/TRAF1/STAT3/TRAF5/CDC42/CCND2/NFKB1/MAPK1/TBPL1/JAK3/EP300/MDM2/HLA-F/HNRNPK/VDAC3/KAT2B/HLA-B/RBL2/PIK3CD/JAK1/GTF2A2/TRAF3/PIK3CA/ATF2/UBE3A/GTF2H2C/SNW1/YWHAZ/MAD1L1/RBL1/IRF3/HDAC9/CCR5/ATF6B/CREB1/USP7/HLA-A/RB1/HDAC3/GRB2/RANBP1/NFKB2/HDAC1/GTF2H3/STAT5B/YWHAB/CDKN2B/POLB/REL/RELA/BAK1/GTF2A1/GTF2H1/KAT2A/DLG1/PIK3R1/HDAC8/CCR4/CDK6/JUN/DNAJA3	5.04047493240667
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	56/2075	142/9376	1.78196504327168	SOCS1/JUND/LCK/IRF9/IFNGR1/PLCG2/PPP3CA/CYLD/STAT1/NFKB1/MAPK1/PPP3CC/LCP2/STAT2/PIK3CD/JAK1/CAMK4/PIK3CA/TGFBR2/TEC1/ATP2A2/TRAF6/IKBKB/NCF4/MAPK13/PPP3R1/SIRPG/CREB1/MAP2K1/MAPK8/ITPR1/GRB2/IFNG/NFKB2/MAP2K6/AKT1/PPP3CB/CSF1/MAP3K7/RELA/FOSB/TYK2/MAP3K14/ITPR3/MAPK9/CHUK/NFATC1/NFATC2/PIK3R1/TNFSF11/SOCS3/FYN/JUN/ITPR2/TMEM64/TAB1	5.00541499721478
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	48/2075	117/9376	1.85376583256101	EPC1/PHF6/BRD7/ACTR6/CHD3/DPF2/SMARCA2/ARID1B/RBBP4/SMARCE1/SMARCC2/DPF3/SMARCA5/EPC2/PHF10/GATAD2A/BCL7B/ARID2/UCHL5/RBBP7/MBD2/SMARCC1/TRRAP/GATAD2B/CDK2AP2/BCL7C/ING3/PBRM1/ACTR8/BPTF/INO80/ACTL6A/YEATS4/MEAF6/CHRAC1/HDAC1/MORF4L1/MRGBP/MORF4L2/BRD8/DMAP1/BICRAL/INO80D/MTA2/SS18/SMARCD1/INO80B/ACTR5	4.95396773613801
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	86/2075	253/9376	1.53595123577313	ATM/CYCS/CALCOCO2/CGAS/TIFA/UBE2V1/MALT1/PLCG2/TRAF5/CDC42/MAP1LC3B/ARF6/UBE2D3/PPID/CASP1/CASP4/BCL10/NFKB1/MAPK1/GLMN/HCLS1/RBCK1/FNBP1/RPS6KB1/ARPC5L/MDM2/MYL12A/BCL2/UBE2N/ACTR2/ACTR3/TBK1/DIAPH1/UBB/PIK3CD/PRKCQ/ATG16L1/CAPN2/ARPC1B/ATG12/PIK3CA/UBE2D2/PYCARD/SKP1/CYTH4/ATG5/TRAF6/IRF3/IKBKB/CUL1/PLCB2/MAPK13/UBE2V2/MYL12B/ROCK1/MAPK8/RPS6KA5/ITPR1/ARF1/CYTH1/PLCG1/PIK3C3/AKT1/ARPC3/CD44/ACTR3C/MAP3K7/RELA/CRKL/CYTH2/BTRC/RRAGB/ITPR3/MAPK9/CHUK/PIK3R1/CCL5/PLCB1/GSK3A/U2AF1L4/JUN/ITPR2/WIPI2/TAB1/UBC/MTOR	4.60702123774591
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	33/2075	73/9376	2.04263409803598	STK4/KRAS/PLCG2/STAT3/MAPK1/JAK3/SOS2/RASSF1/PRKCA/PIK3CD/GADD45A/PIK3CA/RASSF5/MAP2K2/SOS1/EML4/MAP2K1/RB1/PLCG1/GRB2/KIF5B/AKT1/STAT5B/BAK1/RAF1/DDB2/E2F3/BRAF/FHIT/PIK3R1/CDK6/KIF5C/PDPK1	4.76744133889194
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	49/2075	125/9376	1.77127325301205	PPP2R5C/RAC2/KRAS/PPP2R5A/ORMDL1/GNAI3/PTEN/NFKB1/MAPK1/ORMDL3/PPP2R2A/BCL2/DEGS1/S1PR4/PPP2R3C/PPP2CA/PRKCA/PIK3CD/PIK3CA/GNA13/MAP2K2/PLCB2/CERS5/SPHK2/SPTLC2/MAPK13/ROCK1/PPP2R2D/CERS2/SGMS1/MAP2K1/MAPK8/SPTLC1/NSMAF/PPP2R2B/AKT1/BID/CERS6/ABCC1/RELA/RAF1/MAPK9/PIK3R1/S1PR5/S1PR1/SPTSSB/FYN/PLCB1/PDPK1	4.62777729772914
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	31/2075	68/9376	2.05992912827782	PIM2/PIM1/KRAS/STAT3/NFKB1/LEF1/MAPK1/RPS6KB1/SOS2/PIK3CD/PIK3CA/MAP2K2/SOS1/IKBKB/TCF7/MAP2K1/GRB2/AKT1/KIT/STAT5B/RELA/RAF1/BRAF/PML/CHUK/PIK3R1/PPARD/PER2/RARA/MTOR/ZBTB16	4.67634572004752
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/2075	133/9376	1.73267868466347	STK4/ATM/CDKN1B/BCL2L11/KRAS/STAT3/SIRT1/CCND2/PTEN/MAPK1/SOS2/EP300/MDM2/S1PR4/AGAP2/RBL2/PIK3CD/GADD45A/ATG12/PIK3CA/CAT/KLF2/TGFBR2/MAP2K2/SOS1/IKBKB/GABARAPL2/MAPK13/FASLG/PLK3/CDKN2D/USP7/PRKAA1/MAP2K1/MAPK8/SMAD4/GRB2/AKT1/BCL6/CDKN2B/RAF1/BRAF/GABARAPL1/STK11/MAPK9/PRKAG2/CHUK/PIK3R1/S1PR1/PLK2/PDPK1	4.53666191439754
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	32/2075	72/9376	2.00824631860776	CASP8/TANK/ADAR/IRF7/DDX3X/CYLD/RNF125/NFKB1/SIKE1/TBK1/TRAF3/ATG12/ZNFX1/CASP10/ATG5/AZI2/TRAF6/IRF3/IKBKB/IFIH1/MAPK13/OTUD5/IKBKE/MAPK8/MAP3K1/MAP3K7/RELA/ISG15/MAPK9/DHX58/CHUK/TRIM25	4.57827163955691
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	29/2075	63/9376	2.07996940141518	EZH2/NSD1/PRDM2/SETD2/EHMT1/DLD/KMT2E/SMYD3/KMT2B/ASH1L/KMT5B/KMT2A/NSD2/GCDH/PHYKPL/NSD3/EZH1/EHMT2/DLST/KMT5A/ALDH3A2/ALDH9A1/HADH/ACAT2/SMYD2/KMT2D/SETDB2/SETDB1/CAMKMT	4.58501159851477
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	29/2075	63/9376	2.07996940141518	CCNH/GTF2H2/POLR2K/POLR2B/RFC1/RFC4/POLR2C/MNAT1/GTF2H2C/RFC2/XPA/POLR2J/POLR2D/POLR2M/POLR2H/RAD23B/ERCC5/GTF2H3/ERCC1/DDB2/RPA3/GTF2H1/LIG1/POLE/RPA1/PCNA/POLD4/ERCC6/CUL4B	4.58501159851477
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	33/2075	77/9376	1.93652323580034	RAC2/KRAS/STAT3/CDC42/STAT1/NFKB1/MAPK1/RPS6KB1/ARHGEF6/PIK3CD/GADD45A/JAK1/PIK3CA/TGFBR2/IKBKB/MAP2K1/MAPK8/RB1/RALGDS/SMAD4/AKT1/RELA/BAK1/RAF1/DDB2/E2F3/BRAF/RALB/MAPK9/CHUK/PIK3R1/CDK6/MTOR	4.3989528823792
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	114/2075	368/9376	1.39976951283394	CASP3/PSMD12/SRSF7/HNRNPA2B1/TANK/HSPA5/PSMA6/HNRNPA3/NUP98/CYCS/SRSF3/PSMA2/MAP1LC3B/PPP3CA/ERN1/CASP1/NUP58/RANBP2/PPP3CC/NRBF2/DERL1/NUP153/UBQLN1/NDUFV2/RAB8A/SETX/SDHD/PSMD6/BCL2/DDIT3/PSMC6/PSMA3/PSMC4/NUP54/OPTN/NXT1/XBP1/NDUFB8/NUP50/ATP5F1C/TBK1/HNRNPA1/PSMA1/PSMD11/SDHA/TUBA1A/NUP205/PSMD13/NUP88/NDUFB5/NDUFA5/EIF2S1/CAT/ATXN2L/PSMA5/NUP107/FUS/NUP210/TUBA4A/NCBP1/NDUFC2/ATXN2/UQCRFS1/DCTN4/PSMD9/UQCRH/MAPK13/RAB5A/APAF1/NDUFB3/CHCHD10/PPP3R1/UQCRC2/SPG11/SOD1/PSMC2/NXF1/TUBB2A/NDUFA7/COX7A2L/ATP5MC3/TPR/PIK3C3/MAP2K6/KIF5B/DCTN6/BID/ALYREF/PPP3CB/COX7B/POM121C/NUP160/MAP2K3/KLC1/COX7A2/ACTR10/RAB39B/NUP43/CHMP2B/ATG2A/ITPR3/EIF2AK3/NUP62/NUP188/MCU/NDUFA8/SEH1L/NDUFA9/WIPI2/KIF5C/COX7C/NUP133/C9orf72/MTOR	4.17083400808465
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	18/2075	33/9376	2.46466593647317	VTI1A/VAMP2/GOSR1/SEC22B/STX5/STX16/VAMP1/STX11/STX17/VAMP7/VAMP4/STX4/STX3/GOSR2/STX6/STX1A/BET1L/USE1	4.49320146042638
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	30/2075	69/9376	1.96458878994238	RAC2/KRAS/PLCG2/MAPK1/SOS2/ALOX5AP/LCP2/VAV3/PRKCA/PIK3CD/LAT/PIK3CA/VAV1/MAP2K2/SOS1/INPP5D/MAPK13/MAP2K1/MAPK8/PLCG1/GRB2/MAP2K6/AKT1/MAP2K3/RAF1/MAPK9/PIK3R1/FYN/MAP2K4/PDPK1	4.28711776311355
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	52/2075	144/9376	1.63170013386881	GTF2B/PSMD12/PSMA6/CYCS/PSMA2/ERN1/NRBF2/TBPL1/PSMD6/PSMC6/PSMA3/PSMC4/ATXN1/OPA1/VDAC3/XBP1/PRKCA/PIK3CD/VDAC2/PSMA1/PSMD11/SLC25A5/PSMD13/PIK3CA/ATXN2L/PSMA5/ATXN2/ATP2A2/NOP56/PUM1/PSMD9/PLCB2/MAPK8/PSMC2/ITPR1/ATXN10/PUM2/PIK3C3/OMA1/AKT1/RYR1/ATG2A/ITPR3/MAPK9/MCU/PIK3R1/PLCB1/AFG3L2/ITPR2/WIPI2/ATXN1L/MTOR	4.07237564601167
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	50/2075	138/9376	1.63715732495198	SOCS1/PRKACB/PPP1CB/KRAS/PRKAR1A/MAPK1/CBLB/RPS6KB1/SOS2/PPP1CC/MKNK2/PIK3CD/PIK3CA/CBL/MAP2K2/SOS1/SOCS4/CALM1/IKBKB/ACACA/EIF4E/PHKB/MKNK1/PRKAA1/MAP2K1/MAPK8/RHEB/GRB2/AKT1/TSC2/SREBF1/RAF1/CRKL/PPP1R3B/ELK1/SOCS2/CALM2/BRAF/MAPK9/PRKAG2/PIK3R1/PPP1R3D/PDE3B/SOCS3/EXOC7/TSC1/PPP1R3E/PYGB/PDPK1/MTOR	4.01976587485697
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	30/2075	71/9376	1.90924826064823	SOCS1/IRF1/KRAS/STAT3/STAT1/CCND2/NFKB1/MAPK1/SOS2/CISH/PIK3CD/PIK3CA/MAP2K2/SOS1/SOCS4/MAPK13/MAP2K1/MAPK8/GRB2/AKT1/STAT5B/RELA/RAF1/SOCS2/GALT/MAPK9/PIK3R1/TNFSF11/SOCS3/CGA	4.09974626675161
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	17/2075	32/9376	2.40048192771084	CASP3/CASP8/PMAIP1/BCL2L11/CYCS/BIRC6/BIRC2/BCL2/APAF1/MAPK8/HTRA2/CASP7/BBC3/BIRC3/BID/BAK1/MAPK9	4.23047952727469
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	31/2075	75/9376	1.86766907630522	CASP3/CASP8/PMAIP1/ATM/CYCS/TOP2B/MAPK1/MDM2/BIRC2/BCL2/PIK3CD/PIK3CA/XPA/FAS/MLH1/FASLG/APAF1/ATP7A/BBC3/POLH/BIRC3/AKT1/BID/ERCC1/BAK1/MSH2/PIK3R1/GSTM2/MSH3/GSTM4/PDPK1	4.02182753836028
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	40/2075	105/9376	1.72135398737808	USP15/CALCOCO2/KRAS/HIF1A/MAP1LC3B/ARIH1/HUWE1/OPTN/OPA1/TBK1/UBB/TAX1BP1/NBR1/EIF2S1/CCZ1/CSNK2A1/GABARAPL2/RAB5A/MTX3/TOMM70/SIAH1/MAPK8/TBC1D15/CCZ1B/RHOT1/RELA/MTX2/TFEB/GABARAPL1/MAPK9/EIF2AK3/CSNK2A2/SMURF2/RRAS2/TOMM7/JUN/PGAM5/SAMM50/UBC/MUL1	3.96262805758991
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	93/2075	300/9376	1.40075180722892	HSPA1A/CASP3/HSPA1B/HSPA8/DUSP10/JUND/STK4/PRKACB/HSPA6/RAC2/RASA2/KRAS/ELK4/PTPN7/CDC42/PPP3CA/NFKB1/MAPK1/PPP3CC/RAP1A/SOS2/RAP1B/MKNK2/DDIT3/MAX/DUSP2/DUSP5/PRKCA/MAP3K12/MAP3K8/GADD45A/ATF2/DUSP1/ARRB2/MAP4K1/TGFBR2/MAP2K2/SOS1/MAPKAPK3/TRAF6/DUSP4/PPM1B/IKBKB/FAS/RASGRP1/PAK2/MAPK13/FASLG/PPP3R1/MAP4K4/MKNK1/MAP2K1/MAPK8/MAPKAPK5/RPS6KA5/NFATC3/DUSP16/GRB2/AREG/PPM1A/NFKB2/MAP2K6/NF1/AKT1/KIT/MAP3K2/RPS6KA3/PPP3CB/CSF1/MAP3K1/STMN1/FLT3LG/MAP2K3/MAP3K7/RELA/RAF1/CRKL/ELK1/IRAK4/LAMTOR3/DUSP8/MAP3K14/BRAF/MAPK9/CHUK/NFATC1/RRAS2/RASA1/PDGFA/JUN/MAP2K4/TAB1/DUSP7	3.76090521168779
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	44/2075	120/9376	1.65680321285141	KRAS/PLCG2/CDC42/NFKB1/MAPK1/RAP1A/SOS2/RAP1B/BCL2/ZNF274/PIK3CD/CAMK4/CAMK2D/PIK3CA/MATK/KIDINS220/MAP2K2/SOS1/TRAF6/CALM1/IKBKB/MAPK13/FASLG/MAP2K1/MAPK8/RPS6KA5/PLCG1/GRB2/AKT1/RPS6KA3/MAP3K1/PSEN1/ARHGDIB/RELA/RAF1/NFKBIE/CRKL/IRAK4/CALM2/BRAF/MAPK9/PIK3R1/JUN/PDPK1	3.8602704565886
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	33/2075	83/9376	1.7965336042967	CASP3/CASP8/ADAR/IRF7/POLR2K/CGAS/IFI16/CASP1/G3BP1/NFKB1/POLR1D/ZBP1/SAMHD1/AIM2/POLR3K/POLR3GL/POLR3E/TBK1/PYCARD/MLKL/POLR3A/IRF3/IKBKB/POLR2H/IKBKE/CASP7/GSDMD/RELA/POLR3D/POLR3F/POLR3C/CHUK/CCL5	3.88569487672314
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	31/2075	77/9376	1.81915819120638	CDKN1B/KRAS/NFKB1/MAPK1/SOS2/MDM2/PIK3CD/GADD45A/PIK3CA/CBL/TGFBR2/MAP2K2/SOS1/IKBKB/MAP2K1/RB1/SMAD4/GRB2/HDAC1/AKT1/STAT5B/RELA/BAK1/RAF1/CRKL/DDB2/E2F3/BRAF/CHUK/PIK3R1/CDK6	3.84767632941044
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	44/2075	122/9376	1.62964250444401	PRKACB/CTNNB1/KRAS/PLCG2/MED4/HIF1A/STAT1/MAPK1/PFKP/EP300/MDM2/NCOA3/MED13/KAT2B/NCOR1/PRKCA/PIK3CD/SIN3A/NCOA1/PIK3CA/MED17/MAP2K2/ATP2A2/ATP1A1/PLCB2/MAP2K1/HDAC3/PLCG1/RHEB/NCOA2/MED1/HDAC1/AKT1/TSC2/MED14/RAF1/KAT2A/MED30/TBC1D4/PIK3R1/PLCB1/PDPK1/MTOR/NOTCH1	3.73175153338769
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	44/2075	122/9376	1.62964250444401	SOCS1/PRKACB/KRAS/PLCG2/STAT3/STAT1/GNAI3/MAPK1/SOS2/EP300/PRKCA/PIK3CD/PIK3CA/ATF2/MAP2K2/SOS1/ATF6B/PLCB2/MAPK13/CREB1/MAP2K1/MAPK8/ITPR1/PLCG1/GRB2/MAP2K6/AKT1/STAT5B/MAP3K1/ADCY7/MAP2K3/RAF1/CRKL/SOCS2/ITPR3/MAPK9/ADCY3/PIK3R1/SOCS3/PLCB1/GNAS/ITPR2/MAP2K4/MTOR	3.73175153338769
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	35/2075	91/9376	1.73790546802595	RAC2/KRAS/MALT1/PLCG2/PPP3CA/BCL10/NFKB1/MAPK1/PPP3CC/CARD11/SOS2/VAV3/PIK3CD/PIK3CA/VAV1/MAP2K2/SOS1/IKBKB/INPP5D/PPP3R1/MAP2K1/NFATC3/GRB2/AKT1/PPP3CB/CD79B/RELA/RAF1/NFKBIE/DAPP1/CHUK/NFATC1/NFATC2/PIK3R1/JUN	3.7708042265296
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	37/2075	98/9376	1.70598475534792	SACM1L/PLCG2/PIP4K2A/PTEN/DGKZ/IMPA1/DGKD/IP6K1/DGKA/MTM1/PRKCA/PIK3CD/PIK3CA/DGKE/PPIP5K2/INPP4A/CALM1/PLCB2/INPP5D/IP6K2/ITPR1/MTMR6/PIP5K1A/PLCG1/PIK3C3/MTMR1/INPP5F/CALM2/SYNJ2/ITPR3/PIK3R1/INPP4B/PLCB1/ITPR2/SYNJ1/MTMR14/PIP4P1	3.74528345000374
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	17/2075	34/9376	2.25927710843373	POLR2K/POLR2B/POLR1D/CRCP/POLR2C/POLR3K/POLR3GL/POLR3E/POLR2J/POLR3A/POLR2D/POLR2M/POLR2H/POLR3D/POLR3F/POLR3C/POLR1B	3.92142894575367
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	41/2075	112/9376	1.65411359724613	HSPA1A/CASP3/CASP8/SOCS1/HSPA1B/HSPA8/HSPA6/CYCS/IFNGR1/IL10RA/STAT3/STAT1/GNAI3/NFKB1/MAPK1/BIRC2/BCL2/PIK3CG/JAK1/TRAF6/IKBKB/CCR5/MAPK13/MAPK8/IFNG/MAP2K6/BIRC3/AKT1/MAP2K3/IL10RB/MAP3K7/RELA/TYK2/IRAK4/HLA-DQA2/MAPK9/CHUK/PIK3R6/TAB1/PDPK1/CD40LG	3.71249972090406
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	9/2075	13/9376	3.12822984244671	XRCC5/FEN1/PRKDC/XRCC6/DCLRE1C/MRE11/LIG4/XRCC4/RAD50	4.09341906193253
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	25/2075	59/9376	1.91464161731672	CTNNB1/KRAS/PTEN/LEF1/MAPK1/SOS2/PIK3CD/GADD45A/PIK3CA/MAP2K2/SOS1/MLH1/TCF7/MAP2K1/GRB2/AKT1/BAK1/RAF1/DDB2/ELK1/APC/BRAF/AXIN1/PIK3R1/PDPK1	3.75701069192799
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	63/2075	193/9376	1.47496847493601	ITK/CXCR4/PRKACB/RAC2/GNG2/KRAS/PLCG2/STAT3/CDC42/WAS/STAT1/GNAI3/NFKB1/DOCK2/MAPK1/JAK3/RAP1A/SOS2/RAP1B/XCL1/PREX1/STAT2/VAV3/PIK3CD/PIK3CG/PIK3CA/VAV1/ARRB2/SOS1/XCL2/IKBKB/CCR5/PLCB2/ROCK1/MAP2K1/GRK2/PLCG1/GNG5/GRB2/GRK6/AKT1/CXCR6/STAT5B/GNB5/ADCY7/CCR7/RELA/RAF1/CRKL/BRAF/CHUK/PIK3R6/ADCY3/PIK3R1/GNG10/CCL5/CCR1/CCR4/PLCB1/GSK3A/GNGT2/CCR2/TIAM1	3.55430475055048
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	33/2075	86/9376	1.73386382740263	CDKN1B/KRAS/PLCG2/MAPK1/CBLB/RPS6KB1/SOS2/NCK1/PRKCA/PIK3CD/CAMK2D/PIK3CA/CBL/MAP2K2/SOS1/PAK2/MAP2K1/MAPK8/NCK2/PLCG1/GRB2/AREG/AKT1/STAT5B/RAF1/CRKL/ELK1/BRAF/MAPK9/PIK3R1/JUN/MAP2K4/MTOR	3.64468806570878
Human Diseases	Cancer: specific types	hsa05214	Glioma	30/2075	76/9376	1.78363982244769	KRAS/PLCG2/PTEN/MAPK1/SOS2/MDM2/PRKCA/PIK3CD/GADD45A/CAMK4/CAMK2D/PIK3CA/MAP2K2/SOS1/CALM1/MAP2K1/RB1/PLCG1/GRB2/AKT1/BAK1/RAF1/DDB2/E2F3/CALM2/BRAF/PIK3R1/PDGFA/CDK6/MTOR	3.65666633881348
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/2075	44/9376	2.0538882803943	GTF2B/CCNH/GTF2H2/TAF7/TBPL1/TAF15/MNAT1/GTF2A2/TAF9/TAF12/GTF2H2C/TAF11/GTF2F2/TAF5/GTF2H3/GTF2A1/TAF8/GTF2H1/TAF13/TAF4B	3.73539955505841
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	20/2075	44/9376	2.0538882803943	TDG/RFC1/RFC4/MBD4/PARG/FEN1/TDP1/RFC2/PARP1/PARP4/OGG1/HMGB1/POLG/POLG2/POLB/MUTYH/LIG1/POLE/PCNA/POLD4	3.73539955505841
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	27/2075	67/9376	1.82090990828988	PRKACB/PPP1CB/KRAS/PPP3CA/MAPK1/PPP3CC/RAP1A/RAP1B/EP300/PPP1CC/PRKCA/CAMK4/CAMK2D/MAP2K2/CALM1/PLCB2/PPP3R1/MAP2K1/ITPR1/RPS6KA3/PPP3CB/RAF1/CALM2/BRAF/ITPR3/PLCB1/ITPR2	3.59488414227838
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	84/2075	275/9376	1.38021292442497	HSPA1A/CASP3/STIP1/HSPA1B/HSPA8/PSMD12/NCAM1/HSPA5/PSMA6/PRKACB/HSPA6/CYCS/RAC2/PSMA2/PPP3CA/MAPK1/PPP3CC/NDUFV2/SDHD/PSMD6/DDIT3/PSMC6/PSMA3/PSMC4/VDAC3/NDUFB8/ATP5F1C/PIK3CD/VDAC2/PSMA1/PSMD11/SDHA/TUBA1A/SLC25A5/PSMD13/NDUFB5/PIK3CA/ATF2/NDUFA5/EIF2S1/PSMA5/TUBA4A/NDUFC2/CSNK2A1/UQCRFS1/ATF6B/PSMD9/NCF4/UQCRH/MAPK13/APAF1/NDUFB3/PPP3R1/UQCRC2/CREB1/PRNP/SOD1/MAPK8/PSMC2/ITPR1/TUBB2A/NDUFA7/COX7A2L/ATP5MC3/KIF5B/PPP3CB/COX7B/KLC1/COX7A2/RYR1/ITPR3/MAPK9/EIF2AK3/MCU/PIK3R1/CSNK2A2/NDUFA8/CCL5/FYN/NDUFA9/ITPR2/KIF5C/COX7C/NOTCH1	3.4115534492167
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	136/2075	480/9376	1.28025702811245	CASP3/CASP8/PSMD12/TANK/HSPA5/PSMA6/CYCS/CTNNB1/KRAS/PSMA2/CSNK1A1/MAP1LC3B/PPP3CA/PPID/ERN1/NFKB1/MAPK1/PPP3CC/NRBF2/DERL1/NDUFV2/RAB8A/SDHD/PSMD6/BCL2/DDIT3/PSMC6/PSMA3/PSMC4/ATXN1/OPTN/VDAC3/XBP1/NDUFB8/ATP5F1C/TBK1/UBB/PRKCA/VDAC2/PSMA1/PSMD11/SDHA/CAPN2/TUBA1A/CAMK2D/SLC25A5/PSMD13/NDUFB5/NDUFA5/EIF2S1/CAT/ATXN2L/PSMA5/UBE2G1/FUS/TUBA4A/NDUFC2/ATXN2/CSNK2A1/MAP2K2/ATP2A2/UQCRFS1/DCTN4/CALM1/UBE2J1/PSMD9/FAS/PLCB2/UQCRH/MAPK13/FASLG/RAB5A/APAF1/NDUFB3/UBE2L6/PPP3R1/UQCRC2/SPG11/PRNP/SOD1/MAP2K1/MAPK8/HTT/PSMC2/ITPR1/TUBB2A/HTRA2/PLCG1/CASP7/NDUFA7/COX7A2L/ATP5MC3/PIK3C3/MAP2K6/KIF5B/DCTN6/BID/PPP3CB/CSF1/COX7B/PSEN1/MAP2K3/KLC1/COX7A2/RELA/BAK1/ACTR10/RAB39B/RAF1/STX1A/CALM2/APC/RYR1/BRAF/CHMP2B/ATG2A/ITPR3/MAPK9/IFT57/EIF2AK3/MCU/AXIN1/CSNK2A2/FRAT2/NDUFA8/PLCB1/NDUFA9/ITPR2/WIPI2/KIF5C/COX7C/ATXN1L/UBE2J2/UBC/C9orf72/MTOR	3.36034028483509
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	38/2075	105/9376	1.63528628800918	ATM/LCK/MALT1/PLCG2/TRAF1/TRAF5/CYLD/CFLAR/BCL10/NFKB1/CARD11/BIRC2/BCL2/UBE2I/PRKCQ/ZAP70/LAT/GADD45A/TRAF3/CSNK2A1/PARP1/TRAF6/IKBKB/PLCG1/NFKB2/BIRC3/EDARADD/MAP3K7/RELA/IRAK4/MAP3K14/TNFAIP3/CHUK/CSNK2A2/TNFSF11/TRIM25/TAB1/CD40LG	3.48983067053856
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	50/2075	149/9376	1.51629336136492	KRAS/PLCG2/ARF6/MAPK1/DGKZ/SOS2/DGKD/DGKA/PRKCA/PIK3CD/PIK3CG/PIK3CA/GNA13/CYTH4/DNM2/MAP2K2/LPAR6/SOS1/DGKE/PLCB2/SPHK2/MAP2K1/RALGDS/ARF1/PIP5K1A/CYTH1/PLCG1/RHEB/GRB2/AGPAT5/AKT1/KIT/TSC2/ADCY7/RAF1/CYTH2/RALB/PIK3R6/ADCY3/PIK3R1/LPAR2/RRAS2/FYN/PLCB1/AGPAT2/PDGFA/GNAS/TSC1/AGPAT3/MTOR	3.38659239838722
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	36/2075	99/9376	1.64311062431544	RAC2/KRAS/HIF1A/WAS/GPCPD1/MAPK1/DGKZ/RPS6KB1/SOS2/DGKD/DGKA/PRKCA/PIK3CD/PIK3CA/MAP2K2/SOS1/DGKE/MAP2K1/MAPK8/RALGDS/CHKB/PIP5K1A/PLCG1/RHEB/GRB2/AKT1/TSC2/RAF1/MAPK9/PIK3R1/PDGFA/JUN/TSC1/CHKA/PDPK1/MTOR	3.42928056189341
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	52/2075	157/9376	1.49659120558668	CASP3/CASP8/BCL2L11/CYCS/CDC42/ERN1/NFKB1/NDUFV2/SDHD/DDIT3/ITCH/XBP1/NDUFB8/PIK3CD/MLX/SDHA/NDUFB5/PIK3CA/NDUFA5/EIF2S1/NDUFC2/UQCRFS1/IKBKB/FAS/UQCRH/MAPK13/FASLG/NDUFB3/UQCRC2/PRKAA1/ADIPOR2/MAPK8/CASP7/NDUFA7/COX7A2L/AKT1/BID/COX7B/SREBF1/COX7A2/RELA/MLXIP/MAPK9/EIF2AK3/PRKAG2/PIK3R1/NDUFA8/SOCS3/GSK3A/NDUFA9/JUN/COX7C	3.34511041392983
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	34/2075	93/9376	1.65194455240316	PRKACB/KRAS/CDC42/MAPK1/SOS2/PRKCA/CAMK2D/MAP2K2/SOS1/CALM1/PLCB2/MAPK13/MAP2K1/MAPK8/ITPR1/GRB2/MAP2K6/MAP3K2/MAP3K1/ADCY7/MAP2K3/RAF1/ELK1/CALM2/ITPR3/MAPK9/ADCY3/PLCB1/GNAS/GNRH1/JUN/ITPR2/CGA/MAP2K4	3.36830549893826
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	63/2075	200/9376	1.42334457831325	CASP3/CASP8/WIPF1/CYCS/CDC42/ARF6/ARHGEF1/CASP1/CASP4/NFKB1/MAPK1/HCLS1/ARPC5L/NCK1/ACTR2/ACTR3/NCKAP1L/TUBA1A/ARPC1B/GNA13/PYCARD/TUBA4A/NCL/CYTH4/TRAF6/IKBKB/TNFRSF10A/FAS/PAK2/MAPK13/FASLG/OCLN/CYFIP2/ROCK1/MAPK8/MYO1F/ABI1/SEC24B/ARF1/TUBB2A/MYO1G/CYTH1/NCK2/CASP7/ARPC3/EZR/ACTR3C/TMBIM6/MAP3K7/RELA/BAK1/SEC24A/WIPF3/IRAK4/CYTH2/ARHGEF12/WIPF2/MAPK9/CHUK/LPAR2/FYN/JUN/TAB1	3.22615933053982
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/2075	23/9376	2.35750654793085	RFC1/RFC4/RFC2/MLH1/RPA3/MSH2/LIG1/PMS2/RPA1/MSH3/PCNA/POLD4	3.47483268899931
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	36/2075	103/9376	1.57930050298281	CASP8/IFNGR1/CD247/GNAI3/CFLAR/CALR/NFKB1/MAPK1/PPP2R2A/PPP2CA/PIK3CD/PIK3CA/TGFBR2/TRAF6/IKBKB/FAS/PLCB2/MAPK13/FASLG/PPP2R2D/MAPK8/IFNG/CD3G/PPP2R2B/AKT1/CD3E/RELA/IRAK4/MAPK9/CHUK/PIK3R1/CCL5/PLCB1/GNAS/JUN/MAP2K4	3.15148977606852
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	28/2075	75/9376	1.68692690763052	CASP3/CASP8/PMAIP1/ATM/CYCS/CCND3/SESN1/MDM4/CCND2/PTEN/MDM2/BCL2/GADD45A/ATR/CCNG1/RCHY1/TNFRSF10A/FAS/APAF1/SIAH1/BBC3/BID/TSC2/SESN2/DDB2/PPM1D/COP1/CDK6	3.18404980584702
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/2075	82/9376	1.65312959153688	KLRD1/KLRC1/HSPA1A/HSPA1B/KLRC2/HSPA8/HSPA5/HSPA6/HSP90AB1/HSP90AA1/TAP1/B2M/KLRC4/HSPA4/CALR/KLRC3/HLA-F/KIR2DL4/HLA-B/TAP2/CREB1/HLA-A/PDIA3/IFNG/PSME2/CD8B/CD8A/RFXAP/HLA-DQA2/NFYB	3.16671126899178
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	96/2075	333/9376	1.30264626071855	CASP3/CASP8/MX1/OASL/ATM/EIF2AK2/CDKN1B/PRKACB/PPP2R5C/IRF1/CTNNB1/ITGA4/CCND3/KRAS/IRF9/PPP2R5A/CSNK1A1/CDC42/STAT1/CCND2/PTEN/NFKB1/PTGER4/MAPK1/TBPL1/ATP6V0E2/RPS6KB1/SOS2/EP300/MDM2/HLA-F/PPP2R2A/MX2/PPP2R3C/STAT2/PPP2CA/HLA-B/TBK1/RBL2/PIK3CD/ATR/JAK1/TRAF3/PIK3CA/ATP6V1H/UBE3A/ATP6V1G1/MAP2K2/SOS1/LFNG/PATJ/MAML2/RBL1/IRF3/LLGL2/IKBKB/FAS/FASLG/CREB1/DLG3/PPP2R2D/HLA-A/TCF7/IKBKE/MAP2K1/RB1/MFNG/ITGB7/RHEB/GRB2/TCIRG1/PPP2R2B/HDAC1/TADA3/COL9A2/AKT1/TSC2/PSEN1/PARD6B/RELA/BAK1/RAF1/TYK2/HES6/APC/ISG15/DLG1/CHUK/AXIN1/PIK3R1/GNAS/CDK6/TSC1/MAML3/MTOR/NOTCH1	2.99781396430666
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	16/2075	36/9376	2.00824631860776	PRIM1/RFC1/RFC4/MCM3/FEN1/RFC2/RNASEH2B/RPA3/LIG1/POLE/RNASEH1/RPA1/PCNA/POLD4/MCM6/POLA2	3.23108193917741
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/2075	46/9376	1.86635935044526	PSMD12/PSMA6/PSMB9/PSMA2/PSMB8/PSMD6/PSMC6/PSMA3/PSMC4/PSMA1/PSMD11/PSMD13/PSMA5/PSMB10/PSMD9/PSME4/PSMC2/IFNG/PSME2	3.14007250017983
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/2075	56/9376	1.77514629948365	HSPA1A/HSPD1/CASP3/CASP8/HSPA1B/HSPA8/HSPA6/CYCS/CLK4/HBS1L/CASP1/NFKB1/SEC22B/SAR1A/SAR1B/CLK1/PYCARD/APAF1/ARF1/CASP7/NFKB2/RELA	3.10151045797603
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	45/2075	138/9376	1.47344159245678	PRKACB/PPP1CB/PPP2R5C/PPP2R5A/PPP3CA/PTTG1/MAPK1/PPP3CC/PPP1CC/SMC3/PPP2CA/ANAPC5/CAMK2D/ANAPC4/SKP1/YWHAZ/MAD1L1/ANAPC16/ANAPC1/CALM1/CUL1/MAPK13/PPP3R1/MAP2K1/SLK/ITPR1/CDC26/ANAPC10/STAG3/YWHAB/RPS6KA3/PPP3CB/ADCY7/BUB1/CALM2/BTRC/ITPR3/ADCY3/SPDYE16/MAD2L1/CDC23/CDC27/REC8/ITPR2/SPDYA	2.98689865527191
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	53/2075	168/9376	1.42549627079748	CASP8/EIF2AK2/HSP90AB1/HSP90AA1/STAT4/IRF9/IFNGR1/STAT3/TRPM7/TRAF5/CYLD/PPID/STAT1/CASP1/CHMP5/CFLAR/JAK3/RBCK1/ZBP1/DNM1L/BIRC2/BCL2/CHMP7/STAT2/VDAC3/VDAC2/CAPN2/JAK1/CAMK2D/SLC25A5/PYCARD/MLKL/GLUD1/PARP1/TNFRSF10A/FAS/FASLG/VPS4A/MAPK8/HMGB1/CHMP4A/IFNG/BIRC3/BID/STAT5B/AIFM1/TYK2/CHMP2B/TNFAIP3/MAPK9/PGAM5/PYGB/SPATA2	2.96668378694617
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	34/2075	98/9376	1.56766166707647	PTPRC/RAC2/PLCG2/CDC42/WAS/ARF6/MAPK1/RPS6KB1/ARPC5L/ACTR2/ACTR3/VAV3/VASP/PRKCA/PIK3CD/LAT/BIN1/ARPC1B/PIK3CA/VAV1/DNM2/MARCKSL1/INPP5D/SPHK2/MAP2K1/PIP5K1A/PLCG1/AKT1/ARPC3/ASAP1/ACTR3C/RAF1/CRKL/PIK3R1	3.01147274186576
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	26/2075	70/9376	1.67832013769363	KRAS/ETS1/HIF1A/CDC42/MAPK1/RAP1A/SOS2/RAP1B/EP300/VHL/PIK3CD/ARNT/PIK3CA/CUL2/MAP2K2/SOS1/PAK2/EGLN1/MAP2K1/GRB2/AKT1/RAF1/CRKL/BRAF/PIK3R1/JUN	3.03672679006735
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	23/2075	60/9376	1.7321124497992	RAC2/KRAS/PLCG2/CDC42/PPP3CA/MAPK1/PPP3CC/SH2D2A/PRKCA/PIK3CD/PIK3CA/MAP2K2/MAPKAPK3/SPHK2/MAPK13/PPP3R1/MAP2K1/PLCG1/AKT1/PPP3CB/RAF1/NFATC2/PIK3R1	3.03278897044737
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/2075	99/9376	1.55182670074236	CDKN1B/PRKACB/KRAS/MAPK1/RPS6KB1/SOS2/MDM2/NCOA3/BCL2/NCOR1/PIK3CD/CDKN2C/PIK3CA/MAP2K2/SOS1/MAPK13/MAP2K1/MAPK8/RB1/GRB2/MED1/AKT1/ADCY7/RAF1/E2F3/BRAF/MAPK9/ADCY3/PIK3R1/GNAS/JUN/DLL1/MTOR/NOTCH1	2.94252420476474
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	37/2075	110/9376	1.51987732749179	CDKN1B/IFNGR1/PLCG2/STAT3/HIF1A/NFKB1/MAPK1/PFKP/RPS6KB1/EP300/MKNK2/VHL/BCL2/PDHA1/PRKCA/PIK3CD/ARNT/CAMK2D/PIK3CA/PGK1/CUL2/MAP2K2/EIF4E/MKNK1/EGLN1/MAP2K1/PFKFB3/PLCG1/IFNG/LDHB/AKT1/RELA/PIK3R1/LDHA/PDHB/PDK1/MTOR	2.92384662220196
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	28/2075	78/9376	1.62204510349089	SACM1L/PLCG2/PIP4K2A/PTEN/IMPA1/IP6K1/MTM1/PIK3CD/PIK3CG/PIK3CA/PPIP5K2/INPP4A/PLCB2/INPP5D/IP6K2/MTMR6/PIP5K1A/PLCG1/PIK3C3/MTMR1/INPP5F/ALDH6A1/SYNJ2/INPP4B/PLCH2/PLCB1/SYNJ1/MTMR14	2.94088417731986
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	16/2075	38/9376	1.9025491439442	PTPRC/LCK/TAP1/ORAI1/JAK3/ICOS/ZAP70/TAP2/ADA/DCLRE1C/CD3E/CD8B/CD8A/RFXAP/IL2RG/CD40LG	2.97193452111817
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	31/2075	90/9376	1.55639089692102	PRKACB/KRAS/SESN1/SIRT1/NFKB1/RPS6KB1/EHMT1/PIK3CD/CAMK4/PIK3CA/ATF2/CAT/ATG5/ATF6B/EIF4E/CREB1/PRKAA1/ADIPOR2/EHMT2/RHEB/AKT1/TSC2/SESN2/ADCY7/RELA/STK11/PRKAG2/ADCY3/PIK3R1/TSC1/MTOR	2.82742077979094
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	49/2075	157/9376	1.41024940526437	CASP3/ATP8A1/ATP11B/ODC1/HIF1A/GPR132/SIRT1/CASP1/CALR/PTGER4/MAPK1/CD47/HAVCR2/PTGER2/DUSP2/DNMT3A/DUSP5/ADAM10/ARNT/CAMK2D/RAB14/ADAM17/MAP2K2/ATP2A2/UQCRFS1/DUSP4/SPHK2/SLC16A1/MAPK13/RAB5A/SIRPG/CREB1/ARG2/MAP2K1/NFATC3/DUSP16/CASP7/TMEM30A/ANO6/CRKL/VPS8/DUSP8/CEBPB/NFATC1/NFATC2/PPARD/S1PR1/ANO9/DUSP7	2.76349951916099
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	14/2075	32/9376	1.97686746987952	HIBCH/ECHDC1/DLD/ACACA/SUCLG1/ACOX1/LDHB/ALDH6A1/SUCLA2/LDHA/BCKDHB/SUCLG2/BCKDHA/ACOX3	2.95085409559043
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	23/2075	62/9376	1.67623785464438	DTX3L/EP300/ATXN1/ITCH/KAT2B/CIR1/SNW1/ADAM17/LFNG/TLE4/MAML2/SPEN/MFNG/HDAC1/DTX3/PSEN1/NUMB/TLE3/KAT2A/DLL1/ATXN1L/MAML3/NOTCH1	2.84793924734598
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	36/2075	109/9376	1.49236653034155	CASP8/IRF7/IRF9/STAT1/NFKB1/MAPK1/STAT2/TBK1/PIK3CD/MAP3K8/JAK1/TRAF3/PIK3CA/MAP2K2/TRAF6/IRF3/IKBKB/MAPK13/IKBKE/MAP2K1/MAPK8/MAP2K6/AKT1/MAP2K3/MAP3K7/RELA/TYK2/IRAK4/MAPK9/CHUK/PIK3R1/CCL5/CD80/JUN/MAP2K4/TAB1	2.75635851666586
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	35/2075	107/9376	1.47803175318095	PRKACB/PPP3CA/SIRT1/PPP3CC/PFKP/PPP4R3B/EP300/PPP4R3A/PDHA1/CAMK2D/ATF2/SIK1/CALM1/ACACA/PLCB2/PPP3R1/CREB1/PHKB/PPP4C/PRKAA1/ITPR1/LDHB/AKT1/PPP3CB/CALM2/ITPR3/PRKAG2/LDHA/PDE3B/PLCB1/SIK2/GNAS/PDHB/ITPR2/PYGB	2.65115859090814
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	13/2075	30/9376	1.95804016064257	SDHD/PDHA1/DLD/SDHA/IDH3A/SUCLG1/ACLY/DLST/IDH1/SUCLA2/MDH1/PDHB/SUCLG2	2.80178604873368
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	31/2075	93/9376	1.50618473895582	CASP3/CKS2/CDKN1B/CYCS/TRAF1/TRAF5/PTEN/NFKB1/BIRC2/BCL2/MAX/PIK3CD/GADD45A/TRAF3/PIK3CA/TRAF6/IKBKB/APAF1/RB1/TRAF4/BIRC3/AKT1/CDKN2B/RELA/BAK1/DDB2/E2F3/FHIT/CHUK/PIK3R1/CDK6	2.61522982808692
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	48/2075	158/9376	1.37272533170657	KRAS/RICTOR/PTEN/LPIN2/MAPK1/SLC3A2/RPS6KB1/SOS2/FNIP1/PRKCA/PIK3CD/SLC7A5/PIK3CA/ATP6V1H/ATP6V1G1/LPIN1/MAP2K2/SOS1/IKBKB/CAB39/EIF4B/EIF4E/PRKAA1/MAP2K1/RHEB/GRB2/AKT1/RPS6KA3/TSC2/SESN2/CLIP1/RAF1/LAMTOR3/PRR5/BRAF/RRAGB/STK11/CHUK/PIK3R1/TBC1D7/NPRL2/MIOS/PRR5L/SEH1L/DDIT4/TSC1/PDPK1/MTOR	2.51885180027499
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	68/2075	238/9376	1.29101549053356	STK4/PRKACB/RAC2/RASA2/GNG2/SHOC2/KRAS/PLCG2/ETS1/CDC42/RASAL3/ARF6/NFKB1/MAPK1/RAP1A/SOS2/RAP1B/RALGAPA1/TBK1/RASSF1/PRKCA/PIK3CD/ZAP70/LAT/PIK3CA/RASSF5/MAP2K2/SOS1/EXOC2/CALM1/IKBKB/RASGRP1/PAK2/FASLG/RALGAPA2/RAB5A/MAP2K1/MAPK8/RALGDS/PLCG1/GNG5/GRB2/NF1/AKT1/KIT/CSF1/GNB5/FLT3LG/RASA3/REL/RELA/RAF1/ELK1/RGL2/CALM2/SYNGAP1/RALB/MAPK9/CHUK/BRAP/PIK3R1/GNG10/RRAS2/RASA1/PDGFA/GNGT2/AFDN/TIAM1	2.424278572723
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	105/2075	388/9376	1.22280462054403	CASP3/CASP8/PSMD12/EIF2AK2/PSMA6/CYCS/CTNNB1/KRAS/PSMA2/CSNK1A1/PPP3CA/PPID/ERN1/NFKB1/MAPK1/PPP3CC/NRBF2/NDUFV2/SDHD/PSMD6/DDIT3/PSMC6/PSMA3/NAE1/PSMC4/VDAC3/XBP1/NDUFB8/ATP5F1C/PIK3CD/VDAC2/PSMA1/ADAM10/PSMD11/SDHA/CAPN2/TUBA1A/SLC25A5/PSMD13/NDUFB5/PIK3CA/NDUFA5/EIF2S1/PSMA5/TUBA4A/NDUFC2/ADAM17/CSNK2A1/RTN3/MAP2K2/ATP2A2/UQCRFS1/CALM1/IKBKB/PSMD9/FAS/PLCB2/UQCRH/APAF1/NDUFB3/PPP3R1/UQCRC2/MAP2K1/MAPK8/PSMC2/ITPR1/TUBB2A/CASP7/NDUFA7/COX7A2L/ATP5MC3/PIK3C3/KIF5B/AKT1/BID/PPP3CB/CSF1/COX7B/PSEN1/KLC1/COX7A2/RELA/RAF1/CALM2/APC/BRAF/ATG2A/ITPR3/MAPK9/EIF2AK3/CHUK/MCU/AXIN1/PIK3R1/SLC39A1/CSNK2A2/FRAT2/NDUFA8/PLCB1/NDUFA9/ITPR2/WIPI2/KIF5C/COX7C/MTOR	2.38952753013895
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	18/2075	48/9376	1.6944578313253	HMGCS1/HIBCH/OXCT1/DLD/AUH/ACADM/ACAA2/HADHB/ALDH3A2/ALDH9A1/IVD/ALDH6A1/HADH/BCKDHB/ACAT2/ACSF3/MCCC1/BCKDHA	2.57143614526461
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	75/2075	268/9376	1.26452076964575	CASP3/PSMD12/HSPA5/PSMA6/PRKACB/CYCS/PSMA2/ERN1/GNAI3/NDUFV2/SDHD/PSMD6/DDIT3/PSMC6/PSMA3/PSMC4/VDAC3/XBP1/NDUFB8/ATP5F1C/UBB/VDAC2/PSMA1/PSMD11/SDHA/TUBA1A/CAMK2D/SLC25A5/PSMD13/NDUFB5/NDUFA5/DUSP1/EIF2S1/PSMA5/UBE2G1/TUBA4A/NDUFC2/UQCRFS1/CALM1/UBE2J1/NFE2L2/PSMD9/UQCRH/APAF1/NDUFB3/UBE2L6/UQCRC2/SOD1/MAPK8/PSMC2/ITPR1/TUBB2A/HTRA2/PLCG1/NDUFA7/COX7A2L/ATP5MC3/KIF5B/COX7B/KLC1/COX7A2/CALM2/ITPR3/MAPK9/EIF2AK3/MCU/SLC39A1/NDUFA8/GNAS/NDUFA9/ITPR2/KIF5C/COX7C/UBE2J2/UBC	2.34217412158563
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2075	32/9376	1.83566265060241	PPP2CA/ATG16L1/ATG3/ATG12/ATG5/GABARAPL2/IGBP1/PIK3C3/GABARAPL1/ATG2A/ATG10/WIPI2/MTOR	2.52431228502901
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	30/2075	93/9376	1.45759813447338	RAC2/CTNNB1/CDC42/WAS/LEF1/MAPK1/PDCD10/RAP1A/ACP1/YES1/RAP1B/EP300/MYL12A/TGFBR2/CSNK2A1/CCM2/MYL12B/ROCK1/TCF7/SMAD4/IQGAP1/PTPRJ/HEG1/MAP3K7/CSNK2A2/SMURF2/FYN/SSX2IP/LMO7/AFDN	2.36420460446981
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	50/2075	170/9376	1.32898653437279	CTNNB1/KRAS/PLCG2/CSNK1A1/BRD7/PTEN/LEF1/MAPK1/SMARCA2/RPS6KB1/SOS2/ARID1B/SMARCE1/SMARCC2/DPF3/PHF10/PRKCA/PIK3CD/GADD45A/ARID2/PIK3CA/SMARCC1/TGFBR2/MAP2K2/SOS1/NFE2L2/PBRM1/TCF7/MAP2K1/ACTL6A/RB1/SMAD4/PLCG1/GRB2/AKT1/BAK1/RAF1/DDB2/E2F3/ELK1/APC/SMARCD1/BRAF/AXIN1/PIK3R1/FRAT2/GSTM2/CDK6/GSTM4/MTOR	2.30765357074152
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	24/2075	71/9376	1.52739860851858	GLS/KRAS/HIF1A/PTEN/MAPK1/PFKP/PDHA1/PIK3CD/SLC7A5/PIK3CA/MAP2K2/MAP2K1/LDHB/AKT1/KIT/RAF1/TIGAR/IDH1/SIRT6/PIK3R1/LDHA/PDHB/PDK1/MTOR	2.3780089222525
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	42/2075	139/9376	1.36531854034844	HSPA1A/HSPA1B/HSPA8/PRKACB/FKBP5/HSPA6/HSP90AB1/HSP90AA1/FKBP4/KRAS/GNAI3/MAPK1/SOS2/NCOA3/BCL2/PIK3CD/NCOA1/PIK3CA/ATF2/MAP2K2/KRT10/SOS1/CALM1/ATF6B/PLCB2/CREB1/MAP2K1/ITPR1/GRB2/NCOA2/AKT1/ADCY7/RAF1/CALM2/ITPR3/ADCY3/PIK3R1/PLCB1/GNAS/JUN/ITPR2/RARA	2.3132211612081
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	34/2075	109/9376	1.40945727865591	OGT/PPP1CB/STAT3/PTEN/NFKB1/RPS6KB1/PPP1CC/PIK3CD/MLX/PRKCQ/PIK3CA/IKBKB/CREB1/PRKAA1/MAPK8/SLC27A2/AKT1/OGA/RPS6KA3/SREBF1/RELA/PPP1R3B/MLXIP/MAPK9/PRKAG2/TBC1D4/PIK3R1/PPP1R3D/SLC27A3/SOCS3/PPP1R3E/PYGB/PDPK1/MTOR	2.29221725621994
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	66/2075	235/9376	1.2690407587798	PRKACB/KRAS/SMARCA2/NDUFV2/RPS6KB1/SOS2/ARID1B/COX20/SDHD/SMARCE1/SMARCC2/COA1/DPF3/NDUFB8/ATP5F1C/SDHA/COX11/NDUFB5/ATF2/NDUFA5/KDM3A/SMARCC1/COA6/COA5/NDUFC2/SOS1/UQCRFS1/NDUFAF1/NDUFAF4/ACSL3/UQCRH/MAPK13/NDUFB3/UQCRC2/CREB1/PRKAA1/ACTL6A/ACSL4/RHEB/GRB2/NDUFA7/COX19/COX7A2L/ATP5MC3/RPS6KA3/TSC2/COX7B/ADCY7/COX10/MAP2K3/COX7A2/SMARCD1/SIRT6/NDUFAF7/PRKAG2/ADCY3/NDUFA8/NDUFAF5/GNAS/NDUFA9/KDM3B/TSC1/NDUFAF6/COX7C/COA4/MTOR	2.22668441963383
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	43/2075	144/9376	1.34929049531459	TRA2A/CASP3/CASP8/CTNNB1/SIRT1/TRA2B/NFKB1/LPIN2/LEF1/TBK1/TRAF3/LPIN1/ACADM/TRAF6/IRF3/IKBKB/ACACA/FAS/MAPK13/FASLG/ACADVL/TCF7/PRKAA1/IKBKE/ADIPOR2/MAPK8/ACOX1/MAP2K6/AKT1/SREBF1/MAP2K3/MAP3K7/ALDH3A2/RELA/ALDH9A1/IRAK4/MAP3K14/MAPK9/PRKAG2/CHUK/MAP2K4/TAB1/ACOX3	2.25176793582556
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	10/2075	23/9376	1.96458878994238	IDI1/HMGCS1/NUS1/HMGCR/FNTA/GGPS1/ZMPSTE24/ACAT2/RCE1/DHDDS	2.46907439514228
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	27/2075	83/9376	1.46989113078821	ECI2/AGPS/FAR1/CAT/ACSL3/PEX2/SOD1/ACOX1/FAR2/ACSL4/ECH1/SLC27A2/PEX16/PEX26/CROT/IDH1/SCP2/ABCD2/MPV17L/PEX13/EPHX2/ABCD3/PEX6/PECR/PAOX/ACOT8/ACOX3	2.29224925310406
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	49/2075	168/9376	1.31791164658635	SOCS1/PIM1/STAT4/CCND3/IRF9/IFNGR1/IL10RA/STAT3/STAT1/CCND2/MCL1/PTPN2/JAK3/IL2RB/SOS2/EP300/STAM/IL27RA/BCL2/CISH/STAT2/PIK3CD/JAK1/PIK3CA/SOS1/SOCS4/IL4R/IL12RB2/GRB2/IFNG/AKT1/STAT5B/PIAS1/IL23A/IL2RG/IL10RB/RAF1/TYK2/OSM/SOCS2/IL12RB1/IL2RA/PIK3R1/STAM2/SOCS3/PDGFA/IL21R/PIAS3/MTOR	2.21657248803006
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	33/2075	106/9376	1.40671970902478	CDKN1B/HSP90AB1/HSP90AA1/CTNNB1/KRAS/PTEN/NFKB1/LEF1/MAPK1/SOS2/EP300/MDM2/BCL2/PIK3CD/PIK3CA/MAP2K2/SOS1/IKBKB/CREB1/TCF7/MAP2K1/RB1/GRB2/AKT1/RELA/RAF1/E2F3/BRAF/CHUK/PIK3R1/PDGFA/PDPK1/MTOR	2.24497649476025
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	40/2075	133/9376	1.35896367424586	PRKACB/PPP1CB/PPP2R5C/GNG2/PPP2R5A/PPP3CA/GNAI3/PPP3CC/PPP1CC/PPP2R2A/PPP2R3C/PPP2CA/PRKCA/CAMK2D/ATF2/ARRB2/CALM1/ATF6B/PLCB2/MAPK13/CREB1/PPP2R2D/MAPK8/ITPR1/GNG5/PPP2R2B/KIF5B/AKT1/PPP3CB/GNB5/CALM2/ITPR3/MAPK9/GNG10/PLCB1/GSK3A/GNAS/GNGT2/ITPR2/KIF5C	2.22266167105896
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	34/2075	110/9376	1.39664403066813	PRKACB/HSP90AB1/HSP90AA1/KRAS/GNAI3/MAPK1/PIK3CD/ANAPC5/STK10/PIK3CA/ANAPC4/MAD1L1/ANAPC16/ANAPC1/MAPK13/MAP2K1/MAPK8/CDC26/ANAPC10/AKT1/RPS6KA3/ADCY7/BUB1/RAF1/BRAF/MAPK9/ADCY3/SPDYE16/PIK3R1/MAD2L1/PDE3B/CDC23/CDC27/SPDYA	2.23076916025713
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	26/2075	80/9376	1.46853012048193	BCL2L11/KRAS/PLCG2/STAT3/PTEN/MAPK1/RPS6KB1/SOS2/BCL2/PRKCA/PIK3CD/JAK1/PIK3CA/MAP2K2/SOS1/EIF4E/MAP2K1/PLCG1/GRB2/NF1/AKT1/RAF1/BRAF/PIK3R1/PDGFA/MTOR	2.24356143466313
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	52/2075	181/9376	1.2981481728017	HSPD1/CASP3/CASP8/CYCS/MALT1/IFNGR1/HSPA9/IL10RA/PPP3CA/STAT1/BCL10/NFKB1/MAPK1/PPP3CC/EP300/BCL2/JAK1/CAMK2D/ATP6V1H/CASP10/TRAF6/CALM1/SPHK2/MAPK13/RAB5A/PLK3/APAF1/PPP3R1/CREB1/MAPK8/TCIRG1/PIK3C3/IFNG/ITGAX/AKT1/BID/PPP3CB/CORO1A/CEBPG/IL23A/RFXAP/IL10RB/RELA/RAF1/IRAK4/CALM2/HLA-DQA2/ARHGEF12/CEBPB/MAPK9/NFYB/VDR	2.15923090318987
Organismal Systems	Immune system	hsa04611	Platelet activation	38/2075	126/9376	1.36273857334098	PRKACB/PPP1CB/PLCG2/ARHGEF1/ORAI1/GNAI3/MAPK1/RAP1A/RAP1B/PPP1CC/MYL12A/APBB1IP/FERMT3/LCP2/STIM1/VASP/PIK3CD/PIK3CG/PIK3CA/GNA13/RASGRP1/PLCB2/MAPK13/MYL12B/ROCK1/ITPR1/PPP1R12A/AKT1/ADCY7/ARHGEF12/ITPR3/PIK3R6/ADCY3/PIK3R1/FYN/PLCB1/GNAS/ITPR2	2.18530299658253
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/2075	37/9376	1.7097232171931	CTNNB1/KRAS/LEF1/MAPK1/GADD45A/MAP2K2/TFG/TCF7/MAP2K1/TPR/CCDC6/BAK1/DDB2/BRAF	2.30591450606431
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	21/2075	62/9376	1.53047804119705	HSPA1A/HSPA1B/HSPA8/PRKACB/HSPA6/KRAS/SIRT1/RPS6KB1/PIK3CD/PIK3CA/CAT/ATG5/PRKAA1/SOD1/HDAC1/AKT1/ADCY7/PRKAG2/ADCY3/PIK3R1/MTOR	2.2340796555596
NA	NA	hsa04517	IgSF CAM signaling	81/2075	299/9376	1.22408993834871	SRGAP3/NCAM1/LCK/SH2D1A/DOK2/SPTAN1/CTNNB1/ITGA4/CD96/PLCG2/CDC42/ARF6/MAPK1/CD48/MBP/RAP1A/ARPC5L/RAP1B/NCK1/MYL12A/MSN/CRTAM/CD2/LY9/ACTR2/ACTR3/LCP2/SLAMF6/VAV3/ICAM3/PRKCA/PIK3CD/PRKCQ/TUBA1A/ARPC1B/SLAMF1/PIK3CA/VAV1/CSK/TUBA4A/TIGIT/SH2D1B/RAPGEF6/MAP2K2/CASK/TRAF6/CD2AP/PAK2/INPP5D/MAPK13/SLAMF7/MYL12B/CD28/DYNLL2/MAP2K1/MAPK8/TUBB2A/NCK2/PLCG1/GRB2/IQGAP1/ITGAX/SRGAP2/AKT1/CD226/ARPC3/EZR/ACTR3C/PARD6B/PLXNA3/CD244/MAPK9/PIK3R1/RASA1/FYN/CD80/DYNLL1/SSX2IP/LMO7/AFDN/PDPK1	2.099376338448
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/2075	31/9376	1.74911776136805	HSPA5/SRP54/SPCS3/SRP9/SRP19/SRP72/SPCS1/SRPRA/SPCS2/SRPRB/SEC61B/SEC11A	2.22712607562686
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	41/2075	140/9376	1.3232908777969	PRKACB/GNG2/KRAS/MAP1LC3B/GNAI3/MAPK1/TFAM/RPS6KB1/PIK3CG/CAMK4/GNA13/KLF2/MAP2K2/NRF1/CALM1/PLCB2/SPHK2/PRKAA1/MAP2K1/ITPR1/SMAD4/GNG5/PIK3C3/AKT1/GNB5/MEF2D/ADCY7/RAF1/CALM2/RYR1/ITPR3/PRKAG2/PIK3R6/ADCY3/PDE3B/GNG10/RRAS2/PLCB1/GNGT2/ITPR2/MTOR	2.05456090838968
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	29/2075	94/9376	1.39402204562933	CASP3/CASP8/JUND/HSP90AB1/HSP90AA1/TRAF5/NFKB1/MAPK1/SRSF1/TBK1/USP25/ANAPC5/TRAF3/TRAF6/IKBKB/MAPK13/IKBKE/MAPK8/IFNG/TRAF4/ELAVL1/MAP3K7/RELA/FOSB/CEBPB/TNFAIP3/MAPK9/CHUK/JUN	2.04676122401495
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	30/2075	99/9376	1.3692588535962	PRKACB/PPP1CB/PLCG2/PTGER4/PPP1CC/PTGER2/PRKCH/PRKCA/PIK3CD/PRKCQ/CAMK2D/PIK3CA/TRPV2/CALM1/PLCB2/MAPK13/MAPK8/ITPR1/PLCG1/MAP2K6/ADCY7/MAP2K3/CALM2/ITPR3/MAPK9/ADCY3/PIK3R1/PLCB1/GNAS/ITPR2	1.96901149050741
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	21/2075	66/9376	1.43772179627601	STAT4/IFNGR1/STAT3/IL18R1/STAT1/NFKB1/IL18RAP/TBX21/IL4R/IL12RB2/GATA3/IFNG/IL23A/IL2RG/RELA/HLA-DQA2/IL12RB1/NFATC1/MAF/JUN/IL21R	1.90238675918378
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	55/2075	201/9376	1.23642030809806	DDX5/ATM/CDKN1B/ELK4/TRAF1/JMJD1C/KDM6A/CCND2/NFKB1/TAF15/IL2RB/MDM2/BIRC2/DDIT3/CCNT2/MAX/NCOR1/SIN3A/GADD45A/CDKN2C/FLI1/CCNT1/FUS/TGFBR2/EWSR1/MLLT3/KMT2A/NSD2/NFKBIZ/GZMB/ID2/ITGB7/SUPT3H/CDK9/TCF3/HDAC1/BIRC3/AFF1/BCL6/ATF1/LDB1/REL/RUNX2/FUT8/RELA/BAK1/DDB2/SS18/CEBPB/PML/MAF/PER2/PDGFA/RARA/ZBTB16	1.8062725655021
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/2075	71/9376	1.40011539114203	CASP3/PLCG2/CDC42/NFKB1/ATP6V0E2/ADAM10/ATP6V1H/CSK/ATP6V1G1/ADAM17/IKBKB/MAPK13/MAPK8/PLCG1/TCIRG1/RELA/MAP3K14/MAPK9/CHUK/CCL5/JUN/MAP2K4	1.80409647408613
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	37/2075	130/9376	1.2860500463392	PRKACB/GNG2/KRAS/GNAI3/NFKB1/MAPK1/SOS2/PRKCA/PIK3CD/PIK3CA/ATF2/ARRB2/TGFBR2/MAP2K2/SOS1/ATF6B/PLCB2/MAPK13/CREB1/MAP2K1/MAPK8/GNG5/GRB2/AKT1/GNB5/ADCY7/RELA/RAF1/MAPK9/ADCY3/PIK3R1/GNG10/PLCB1/GNAS/GNGT2/JUN/MAP2K4	1.75081503956268
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/2075	20/9376	1.80742168674699	LBR/SC5D/HSD17B7/MSMO1/FDFT1/EBP/CYP51A1/SQLE	1.92696495256552
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	55/2075	204/9376	1.21823765650839	CASP3/DDX5/PRKACB/PPP1CB/CTNNB1/KRAS/PLCG2/STAT3/HIF1A/CDC42/ARHGEF1/MAPK1/HCLS1/RPS6KB1/SOS2/MDM2/PPP1CC/MSN/PDCD4/VAV3/PRKCA/PIK3CD/CAMK2D/PIK3CA/CBL/VAV1/NUDT16L1/MAP2K2/SOS1/FAS/MAPK13/FASLG/EIF4B/ROCK1/MAP2K1/ITPR1/PLCG1/GRB2/IQGAP1/PPP1R12A/AKT1/EZR/CD44/RAF1/ELK1/ARHGEF12/BRAF/ITPR3/PIK3R1/RRAS2/SDC4/ITPR2/PDPK1/MTOR/TIAM1	1.6800270124622
Organismal Systems	Endocrine system	hsa04924	Renin secretion	21/2075	69/9376	1.37521215295966	PRKACB/PPP3CA/ORAI1/GNAI3/PTGER4/PPP3CC/PTGER2/ADRB1/CALM1/PLCB2/PPP3R1/CREB1/ITPR1/PPP3CB/CALM2/ITPR3/PDE3B/ADRB2/PLCB1/GNAS/ITPR2	1.66763153652817
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	21/2075	69/9376	1.37521215295966	PRKACB/PPP1CB/PPP3CA/SIRT1/PPP3CC/PPP1CC/PRKCA/CAMK4/CAMK2D/ATF2/CALM1/ATF6B/PPP3R1/CREB1/HDAC1/PPP3CB/FOSB/STX1A/CALM2/GNAS/JUN	1.66763153652817
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/2075	14/9376	1.93652323580034	B3GNT2/B4GALT1/B4GALT4/FUT8/B4GALT3/B3GNT7	1.86939798805607
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	60/2075	227/9376	1.19433151106629	KRAS/PRKD3/HIF1A/PTEN/NFKB1/MAPK1/ACP1/NDUFV2/SOS2/SDHD/VDAC3/NDUFB8/ATP5F1C/PIK3CD/VDAC2/SDHA/ARNT/SLC25A5/NDUFB5/PIK3CA/NDUFA5/CAT/AHR/NDUFC2/MAP2K2/SOS1/UQCRFS1/IKBKB/NFE2L2/UQCRH/MAPK13/NDUFB3/UQCRC2/SOD1/MAP2K1/MAPK8/GRB2/NDUFA7/COX7A2L/ATP5MC3/AKT1/COX7B/PTPRJ/COX7A2/RELA/RAF1/MAP3K14/BRAF/MAPK9/CHUK/PIK3R1/NDUFA8/GSTM2/EPHX2/NDUFA9/JUN/MAP2K4/GSTM4/COX7C/PDPK1	1.58005737356658
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	17/2075	54/9376	1.42250780901383	ATR/MLH1/USP1/WDR48/FANCF/POLH/REV1/ERCC1/PALB2/RPA3/RAD51C/PMS2/RPA1/TOP3A/FAN1/FANCA/UBE2T	1.65989487999104
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/2075	89/9376	1.3200270745905	PRKACB/KRAS/GNAI3/MAPK1/SOS2/PRKCA/TUBA1A/CSNK1D/ADRB1/TUBA4A/MAP2K2/SOS1/PLCB2/MAP2K1/ITPR1/TUBB2A/GRB2/MAP3K2/ADCY7/RAF1/ITPR3/ADCY3/PLCB1/PDGFA/GNAS/ITPR2	1.61713961689294
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/2075	101/9376	1.29740665632828	CASP3/CDKN1B/PIM1/KRAS/PLCG2/STAT3/CDC42/STAT1/NFKB1/MAPK1/BCL2/DIAPH1/PRKCA/PIK3CD/PIK3CA/TGFBR2/PLCB2/MAPK13/MAPK8/SMAD4/PLCG1/AKT1/STAT5B/RELA/MAPK9/NFATC1/PIK3R1/PLCB1/JUN	1.60198308663746
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	46/2075	170/9376	1.22266761162296	RAB8B/PRKACB/WHAMM/CDC42/WAS/HSPA4/RAP2C/HCLS1/RAP1A/ARPC5L/MYL12A/MSN/RAB8A/PPP2R2A/ACTR2/ACTR3/PPP2CA/VASP/TUBA1A/ARPC1B/TUBA4A/RAPGEF6/PATJ/LLGL2/OCLN/MYL12B/ROCK1/DLG3/PPP2R2D/PRKAA1/MAPK8/PPP2R2B/ARPC3/EZR/MAP3K1/ACTR3C/PARD6B/ARHGAP17/STK11/DLG1/MAPK9/PRKAG2/PCNA/JUN/AFDN/TIAM1	1.56188675025819
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/2075	43/9376	1.47115718688708	ECI2/ACADM/ACSL3/ACAA2/ACADVL/ACOX1/GCDH/ACSL4/HADHB/ALDH3A2/ALDH9A1/HADH/ACAT2/ACOX3	1.65079418155311
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	79/2075	308/9376	1.15897981536536	CASP3/CASP8/PSMD12/PSMA6/CYCS/POLR2K/PSMA2/POLR2B/ERN1/NRBF2/TBPL1/TFAM/NDUFV2/EP300/SDHD/PSMD6/POLR2C/PSMC6/PSMA3/PSMC4/VDAC3/NDUFB8/ATP5F1C/SIN3A/VDAC2/PSMA1/PSMD11/SDHA/TUBA1A/SLC25A5/PSMD13/NDUFB5/NDUFA5/PSMA5/TUBA4A/NDUFC2/POLR2J/UQCRFS1/POLR2D/DCTN4/NRF1/PSMD9/PLCB2/UQCRH/APAF1/NDUFB3/POLR2H/UQCRC2/CREB1/SOD1/MAPK8/HTT/PSMC2/ITPR1/TUBB2A/NDUFA7/COX7A2L/BBC3/ATP5MC3/PIK3C3/HDAC1/KIF5B/DCTN6/COX7B/KLC1/COX7A2/ACTR10/STX1A/ATG2A/MAPK9/IFT57/NDUFA8/TAF4B/PLCB1/NDUFA9/WIPI2/KIF5C/COX7C/MTOR	1.51239455560271
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	34/2075	122/9376	1.25926920797946	PPP2R5C/PPP2R5A/SIRT1/PFKP/RPS6KB1/RAB8A/PPP2R2A/PPP2R3C/PPP2CA/PIK3CD/PIK3CA/RAB14/ACACA/HMGCR/CAB39/CREB1/PPP2R2D/PRKAA1/ADIPOR2/PFKFB3/RHEB/PPP2R2B/AKT1/ELAVL1/TSC2/SREBF1/TBC1D1/MAP3K7/STK11/PRKAG2/PIK3R1/TSC1/PDPK1/MTOR	1.53663111624257
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/2075	44/9376	1.43772179627601	PRKACB/VAMP2/NSF/DCTN4/RAB5A/CREB1/STX4/DYNLL2/DCTN6/ARHGDIB/AQP3/ADCY3/DYNLL1/GNAS	1.55146027664055
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	17/2075	56/9376	1.37170395869191	CUL3/PRKACB/CSNK1G3/CSNK1A1/CCND2/BCL2/CSNK1D/ARRB2/SPOP/CSNK1G2/CUL1/GRK2/BTRC/KIF3A/PTCH2/SMURF2/EVC2	1.48725952239209
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	32/2075	116/9376	1.24649771499792	ITK/CXCR4/TXK/RAC2/CTNNB1/ITGA4/PLCG2/CDC42/GNAI3/RAP1A/RAP1B/MYL12A/MSN/RHOH/VAV3/VASP/PRKCA/PIK3CD/PIK3CA/VAV1/RASSF5/SIPA1/NCF4/MAPK13/OCLN/MYL12B/ROCK1/PLCG1/EZR/CD99/PIK3R1/AFDN	1.42409812145074
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	47/2075	178/9376	1.19310139434141	CACYBP/PRKACB/RAC2/CTNNB1/CCND3/CCDC88C/CSNK1A1/PPP3CA/SIRT1/CCND2/LEF1/PPP3CC/EP300/CHD8/TBL1XR1/PRKCA/SENP2/CAMK2D/SKP1/CSNK2A1/TLE4/CUL1/PLCB2/PPP3R1/INVS/SIAH1/TCF7/MAPK8/NFATC3/SMAD4/RYK/PPP3CB/PSEN1/MAP3K7/BTRC/APC/TLE3/MAPK9/NFATC1/NFATC2/AXIN1/CSNK2A2/FRAT2/PPARD/PLCB1/CTNNBIP1/JUN	1.38660327868241
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	13/2075	41/9376	1.4327123126653	ATM/UIMC1/TOPBP1/NBN/MRE11/BARD1/PALB2/RPA3/RAD51C/RPA1/TOP3A/POLD4/RAD50	1.48025840182471
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	7/2075	19/9376	1.66473050095117	PDHA1/DLD/DLST/AMT/BCKDHB/PDHB/BCKDHA	1.54617129749113
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/2075	57/9376	1.34763897696047	HACD4/ACADM/ACACA/ACSL3/ACAA2/ACADVL/ELOVL6/ACOX1/ELOVL5/ACSL4/HADHB/HSD17B12/SCP2/HADH/ACAT2/ACSF3/ACOX3	1.40341059105321
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/2075	65/9376	1.32080815569972	KRAS/MAPK1/PRKCA/PIK3CD/PIK3CA/ARRB2/MAP2K2/PLCB2/MAP2K1/ITPR1/AKT1/RAF1/ITPR3/PIK3R1/PLCB1/KCNN1/GNRH1/ITPR2/CGA	1.38359004965158
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/2075	34/9376	1.46188518781006	BHLHE40/NFIL3/CSNK1D/SKP1/CUL1/CREB1/PRKAA1/BTRC/PER1/PRKAG2/PER2	1.43832515731669
Genetic Information Processing	Translation	hsa03010	Ribosome	57/2075	222/9376	1.16016932595246	RPS10/RPL36A/RPL26/RPS21/MRPS31/RSL24D1/MRPS17/MRPS30/MRPL3/RPL22L1/MRPL9/RPL17/MRPL18/RPS15A/MRPS18C/MRPL44/MRPL34/MRPL19/MRPS15/RPL37/MRPL1/MRPL14/MRPL39/MRPL10/RPL41/MRPL47/MRPS7/MRPS14/MRPL22/MRPL52/RPS29/MRPS5/MRPL30/MRPL50/MRPL32/MRPS35/RPL14/MRPS23/MRPL13/MRPL49/RPS25/DAP3/MRPL38/RPL39/RPS27/RPS7/MRPL4/MRPL35/FAU/MRPL42/RPL30/MRPS27/MRPS9/MRPS28/MRPL53/MRPS22/RPS23	1.28751973799067
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/2075	115/9376	1.21804504976427	JUND/PRKACB/ARHGEF1/GNAI3/MAPK1/PDE4B/STK39/BCL2/PRKCA/ATF2/GNA13/ARRB2/ATF6B/PLCB2/CREB1/MAP2K1/GATA3/ITPR1/OXSR1/MEF2D/ADCY7/RUNX2/RAF1/BRAF/ITPR3/ADCY3/TNFSF11/PLCB1/GNAS/ITPR2/VDR	1.25420845452288
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/2075	39/9376	1.39032437442076	PRF1/HLA-F/HLA-B/FAS/FASLG/GZMB/HLA-A/CD28/IFNG/HLA-DQA2/CD80/CD40LG	1.30214039245132
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	31/2075	116/9376	1.20754466140424	ME2/HIBCH/PFKP/SDHD/PGP/PDHA1/DLD/SDHA/CAT/PGK1/GLUD1/IDH3A/TKT/SUCLG1/ACOX1/RPIA/DLST/TALDO1/ALDH6A1/IDH1/PSAT1/ESD/SUCLA2/MDH1/AMT/ACAT2/PDHB/GLYCTK/SUCLG2/PRPS1/ACOX3	1.19905355887537
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/2075	59/9376	1.30195629977537	NT5C3A/DCK/UPP1/DPYD/CTPS1/CMPK1/DUT/HDDC2/DTYMK/CDADC1/UCKL1/NT5C2/ENTPD4/DHODH/CMPK2/DCTPP1/NUDT2	1.24032519980801
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/2075	28/9376	1.45239242685026	HACD4/THEM4/ACAA2/ELOVL6/ELOVL5/HADHB/HSD17B12/HADH/ACOT2	1.2780225137074
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	52/2075	205/9376	1.14616985013224	PPP1CB/RAC2/PTEN/NFKB1/MPC2/PDK3/NDUFV2/PPP1CC/SDHD/VDAC3/NDUFB8/ATP5F1C/PDHA1/PRKCA/PIK3CD/VDAC2/SDHA/CAMK2D/SLC25A5/NDUFB5/PIK3CA/NDUFA5/TGFBR2/NDUFC2/PARP1/ATP2A2/UQCRFS1/GSR/NCF4/PLCB2/UQCRH/MAPK13/NDUFB3/UQCRC2/MAPK8/MPC1/NDUFA7/COX7A2L/ATP5MC3/AKT1/COX7B/COX7A2/RELA/MAPK9/TBC1D4/PIK3R1/NDUFA8/PLCB1/PDHB/NDUFA9/COX7C/MTOR	1.12805402635562
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/2075	44/9376	1.3350273822563	HSPD1/PRF1/HLA-F/HLA-B/FAS/FASLG/GZMB/HLA-A/CD28/IFNG/HLA-DQA2/PTPRN2/CD80	1.18747039690425
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/2075	60/9376	1.28025702811245	KRAS/GNAI3/MAPK1/PPP2CA/PRKCA/GNA13/MAP2K2/PLCB2/MAP2K1/ITPR1/RAF1/RYR1/BRAF/ITPR3/PLCB1/GNAS/ITPR2	1.16096977176515
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	58/2075	232/9376	1.12963855421687	CXCR4/PPP1CB/RAC2/FGD3/ITGA4/KRAS/CDC42/ARHGEF1/PIP4K2A/MAPK1/SOS2/ARPC5L/ITGAE/PPP1CC/MYL12A/MSN/SSH2/ARHGEF6/ACTR2/ACTR3/VAV3/IQGAP2/NCKAP1L/DIAPH1/PIK3CD/ARPC1B/PIK3CA/GNA13/VAV1/MAP2K2/SOS1/SPATA13/PAK2/CYFIP2/MYL12B/ROCK1/MAP2K1/ITGB7/PIP5K1A/IQGAP1/PPP1R12A/TMSB4X/ITGAX/AKT1/ARPC3/EZR/ACTR3C/ARHGEF7/RAF1/CRKL/APC/ARHGEF12/BRAF/PIK3R1/LPAR2/RRAS2/PDGFA/TIAM1	1.06589291929627
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2075	21/9376	1.50618473895582	DPYD/PANK3/PANK2/AASDHPPT/PPCS/ALDH3A2/CSAD	1.23794204487342
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	59/2075	238/9376	1.12014579325706	MX1/RPS10/ADAR/OAS2/EIF2AK2/OAS1/RPL36A/RPL26/CGAS/IRF9/RPS21/PLCG2/RSL24D1/STAT3/STAT1/CASP1/NFKB1/MAPK1/OAS3/RPL22L1/RPL17/RPS15A/MX2/STAT2/TBK1/PRKCA/PIK3CD/JAK1/TRAF3/PIK3CA/RPL37/ADAM17/RPL41/TRAF6/IRF3/IKBKB/IFIH1/MAPK13/RPS29/IKBKE/MAPK8/PLCG1/RPL14/RPS25/MAP3K7/RELA/TYK2/RPL39/RPS27/IRAK4/ISG15/RPS7/MAPK9/CHUK/PIK3R1/FAU/RPL30/JUN/RPS23	1.00086380852744
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/2075	49/9376	1.29101549053356	OGT/B4GALT1/GALNT3/LFNG/C1GALT1/MFNG/GALNT11/FUT10/GALNT10/B4GALT3/GXYLT1/GALNT1/C1GALT1C1/GALNT2	1.08879639162163
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/2075	41/9376	1.3225036732295	KRAS/MAPK1/MDM2/RASSF1/MAP2K2/MAP2K1/RB1/RPS6KA5/RAF1/E2F3/BRAF/DAPK2	1.10324748786746
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/2075	45/9376	1.30536010709505	KLRD1/KLRC1/PRF1/HLA-F/HLA-B/FAS/FASLG/GZMB/HLA-A/CD28/IFNG/HLA-DQA2/CD80	1.09460638201412
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	30/2075	115/9376	1.17875327396543	PRKACB/GNG2/KRAS/GNAI3/MAPK1/BCL2/PRKCA/PIK3CD/PIK3CG/CAMK4/CAMK2D/PIK3CA/PLCB2/CREB1/MAP2K1/ITPR1/GNG5/AKT1/GNB5/ADCY7/ITPR3/PIK3R6/ADCY3/PIK3R1/GNG10/FYN/PLCB1/GNGT2/ITPR2/KCNQ5	1.02819975836854
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	54/2075	217/9376	1.12443284659375	PTGES3/PRKACB/HSP90AB1/HSP90AA1/CCND3/KRAS/STAT3/GNAI3/KPNA4/NFKB1/MAPK1/RPS6KB1/SOS2/BCL2/KPNA2/PRKCA/PIK3CD/ARNT/PIK3CA/ATF2/ADRB1/ARRB2/AHR/MAP2K2/SOS1/ATF6B/KPNA5/CREB1/IKBKE/MAP2K1/RB1/GRB2/AIP/AKT1/KPNA1/STAT5B/RPS6KA3/BCL6/ADCY7/RELA/RAF1/ADCY3/PIK3R1/TNFSF11/ADRB2/GSTM2/GNAS/EPHX2/KPNA3/JUN/GSTM4/DLL1/VDR/MTOR	0.988654137727248
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	42/2075	166/9376	1.14324865727972	PPP1CB/PPP3CA/GNAI3/MAPK1/PPP3CC/PPP1CC/VDAC3/VASP/VDAC2/PIK3CG/SLC25A5/ATF2/GNA13/ADRB1/MAP2K2/ATP2A2/ATP1A1/CALM1/ATF6B/PLCB2/PPP3R1/CREB1/ROCK1/MAP2K1/ITPR1/NFATC3/PPP1R12A/AKT1/PPP3CB/MEF2D/ADCY7/RAF1/CALM2/ITPR3/NFATC1/NFATC2/PIK3R6/ADCY3/PDE3B/ADRB2/PLCB1/ITPR2	0.99270064323708
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/2075	70/9376	1.22646471600688	CASP3/CASP8/CYCS/RAC2/PRF1/HLA-F/HLA-B/EIF4G2/EIF4G3/HLA-A/CD28/CD55/SNTB1/BID/SNTB2/HLA-DQA2/FYN/CD80/CD40LG	1.01384498540969
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/2075	154/9376	1.14430918479111	PRKACB/PPP1CB/KRAS/PPP3CA/GNAI3/MAPK1/PPP3CC/CD38/PPP1CC/PRKCA/PIK3CG/CAMK4/CAMK2D/MAP2K2/CALM1/PLCB2/PPP3R1/ROCK1/PRKAA1/MAP2K1/ITPR1/NFATC3/PPP1R12A/PPP3CB/ADCY7/RAF1/ELK1/CALM2/RYR1/ITPR3/PRKAG2/NFATC1/NFATC2/PIK3R6/ADCY3/PLCB1/GNAS/JUN/ITPR2	0.962598741014754
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/2075	38/9376	1.30800253646164	SIRT7/SIRT1/CD38/NNT/PNP/SIRT2/NAMPT/NT5C2/SIRT6/NADSYN1/SIRT5	1.01419781609021
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	39/2075	155/9376	1.13692654488923	CDKN1B/PRKACB/CTNNB1/ORAI1/GNAI3/LEF1/MAPK1/RAP1A/RAP1B/CDKN2C/ARNT/CAMK2D/ATF2/AHR/MAP2K2/ATF6B/PLCB2/ASH2L/KMT2A/CREB1/TCF7/MAP2K1/RB1/ITPR1/AIP/CDKN2B/ADCY7/E2F3/RBBP5/APC/BRAF/ITPR3/AXIN1/ADCY3/PLCB1/GNAS/CDK6/ITPR2/KMT2D	0.916363963902572
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	52/2075	212/9376	1.10832461923164	EVL/RAC2/CTNNB1/KRAS/PRKD3/CDC42/SKAP1/GNAI3/MAPK1/RAP1A/RAP1B/RGS14/APBB1IP/LCP2/VAV3/VASP/PRKCA/PIK3CD/LAT/PIK3CA/VAV1/RASSF5/RAPGEF6/MAP2K2/CALM1/SIPA1/PLCB2/MAPK13/MAP2K1/RALGDS/PLCG1/MAP2K6/SIPA1L1/AKT1/KIT/CSF1/ADCY7/PARD6B/MAP2K3/RAF1/CRKL/CALM2/BRAF/RALB/ADCY3/PIK3R1/LPAR2/PLCB1/PDGFA/GNAS/AFDN/TIAM1	0.850464276349665
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/2075	55/9376	1.23233296823658	DEGS1/UGCG/CERS5/SPHK2/SPTLC2/CERS2/SGMS1/SPTLC1/CERS6/NEU1/NEU3/SAMD8/B4GALT5/SMPD3/GALC	0.921222308066704
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	37/2075	148/9376	1.12963855421687	CTNNB1/KRAS/CSNK1A1/PTEN/LEF1/MAPK1/RPS6KB1/SOS2/NCOA3/PIK3CD/GADD45A/NCOA1/PIK3CA/MAP2K2/SOS1/TCF7/MAP2K1/RB1/GRB2/NFKB2/AKT1/KIT/BAK1/RAF1/DDB2/E2F3/APC/BRAF/AXIN1/PIK3R1/TNFSF11/FRAT2/CDK6/JUN/DLL1/MTOR/NOTCH1	0.847451315594276
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/2075	31/9376	1.31183832102604	HIBCH/DPYD/CNDP2/ACOX1/ALDH3A2/ALDH9A1/ALDH6A1/CSAD/ACOX3	0.927094900097519
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2075	27/9376	1.33883087907184	HACD4/ELOVL6/ACOX1/ELOVL5/HSD17B12/SCP2/ACOX3/ACOT2	0.939908980653435
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/2075	85/9376	1.16950815024805	NT5C3A/DCK/HPRT1/UPP1/CTPS1/ADA/CMPK1/DGUOK/GMPS/PNP/NTPCR/DUT/GMPR2/HDDC2/DTYMK/UCKL1/NT5C2/AMPD2/ENTPD4/ADSL/CMPK2/DCTPP1	0.836897618464791
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/2075	56/9376	1.21032702237522	ALG13/B4GALT1/STT3B/MAN1A1/MGAT4A/MGAT2/MOGS/OSTC/MGAT5/DDOST/FUT8/B4GALT3/DAD1/DPM1/ALG11	0.84155914815852
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/2075	73/9376	1.17606205644496	KRAS/PTEN/MAPK1/MDM2/PIK3CD/GADD45A/PIK3CA/MAP2K2/MAP2K1/RB1/AKT1/BAK1/RAF1/DDB2/E2F3/BRAF/PIK3R1/PDGFA/CDK6	0.805043233946732
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/2075	44/9376	1.23233296823658	ALG13/B4GALT1/STT3B/MAN1A1/MGAT4A/MGAT2/OSTC/DDOST/FUT8/B4GALT3/DAD1/ALG11	0.823480517167937
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/2075	70/9376	1.16191394148021	STAT3/NFKB1/PRKCQ/IKBKB/ACSL3/PRKAA1/ADIPOR2/MAPK8/ACSL4/AKT1/RELA/NFKBIE/STK11/MAPK9/PRKAG2/CHUK/SOCS3/MTOR	0.724861870458599
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/2075	75/9376	1.14470040160643	HSPA5/PRKACB/PRKCA/ATF2/TTF1/TTF2/ATP1A1/ATF6B/GSR/PLCB2/CREB1/ITPR1/ADCY7/ITPR3/ADCY3/PLCB1/GNAS/ITPR2/CGA	0.670716608307242
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/2075	97/9376	1.11799279592597	PRKACB/GNG2/GNAI3/MAPK1/PRKCA/CAMK2D/CALM1/PLCB2/CREB1/RPS6KA5/ITPR1/GNG5/GNB5/ADCY7/CALM2/RYR1/PER1/ITPR3/ADCY3/GNG10/PER2/PLCB1/GNAS/GNGT2	0.622722110942373
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	31/2075	128/9376	1.09433734939759	PDE7A/PDE6D/PDE4B/DCK/HPRT1/ENPP4/ADA/DGUOK/GMPS/PNP/NTPCR/ADPRM/GMPR2/HDDC2/PAPSS1/PGM2/PPAT/ADCY7/NUDT5/NT5C2/AMPD2/ENTPD4/FHIT/ADCY3/ADSL/PDE3B/GART/ATIC/HDDC3/NUDT2/PRPS1	0.572886064950515
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	48/2075	203/9376	1.06842661285536	PPP1CB/RAC2/CTNNB1/ITGA4/CCND3/CDC42/CCND2/PTEN/MAPK1/RAP1A/SOS2/RAP1B/PPP1CC/MYL12A/BIRC2/BCL2/VAV3/DIAPH1/VASP/PRKCA/PIK3CD/CAPN2/PIK3CA/VAV1/PARVG/SOS1/PAK2/MYL12B/ROCK1/MAP2K1/MAPK8/ITGB7/PIP5K1A/GRB2/PPP1R12A/BIRC3/COL9A2/AKT1/RAF1/CRKL/ELK1/BRAF/MAPK9/PIK3R1/FYN/PDGFA/JUN/PDPK1	0.52543727584039
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/2075	142/9376	1.08190734770066	RAC2/HSP90AB1/HSP90AA1/CTNNB1/SUMO1/NFKB1/BCL2/SUMO4/PIK3CD/PIK3CA/DUSP1/SUMO2/KLF2/CALM1/IKBKB/NFE2L2/MAPK13/PRKAA1/MAPK8/IFNG/MAP2K6/AKT1/MAP3K7/RELA/CALM2/MAPK9/CHUK/PIK3R1/SDC4/GSTM2/PDGFA/JUN/MAP2K4/GSTM4	0.524294877489221
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/2075	51/9376	1.15178832978975	PRKACB/PLCG2/ATP6V0E2/PRKCA/ATP6V1H/ATP6V1G1/ERO1A/SEC61B/ARF1/PLCG1/TCIRG1/ADCY3/GNAS	0.579432117985482
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/2075	47/9376	1.15367341707255	ME2/PDHA1/DLD/ACYP1/ACACA/LDHB/ALDH3A2/ALDH9A1/LDHA/MDH1/ACAT2/PDHB	0.56303273445328
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/2075	47/9376	1.15367341707255	SOCS1/MAPK1/PIK3CD/PIK3CA/SOCS4/IKBKB/MAPK8/SOCS2/MAPK9/PIK3R1/SOCS3/MTOR	0.56303273445328
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/2075	104/9376	1.08619091751622	ETNK1/GPCPD1/LPIN2/DGKZ/DGKD/DGKA/SELENOI/LPIN1/DGKE/LPCAT4/LPCAT3/CRLS1/SGMS1/ADPRM/CEPT1/CHKB/PGS1/AGPAT5/LPGAT1/SAMD8/MBOAT1/PTDSS1/AGPAT2/CHKA/AGPAT3	0.471188819180728
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/2075	39/9376	1.15860364535063	MAT2A/MTHFD2/MTHFS/DLD/MAT2B/MTHFD1/GART/AMT/ATIC/DMGDH	0.529109188498833
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/2075	78/9376	1.1006734630831	CASP3/IRF1/CASP1/GNAI3/NFKB1/MAPK1/PYCARD/TRAF6/IRF3/CALM1/MAPK13/MAPK8/CASP7/IL23A/RELA/IRAK4/CALM2/MAPK9/JUN	0.475960654614213
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	58/2075	250/9376	1.04830457831325	VPS13C/GNPTAB/IDS/CD164/ATP6V0E2/GGA2/CTSC/AP1G1/VPS26A/BLOC1S2/OSBPL3/OSTM1/ATP6V1H/M6PR/VPS13A/SLC15A4/STX17/ATP6V1G1/VAMP7/LAMP3/PLEKHM1/MFSD8/SPG11/DTNBP1/BLOC1S6/OSBPL7/AP3M2/IGF2R/TCIRG1/MAN2B1/VPS29/DMXL1/MANBA/BLOC1S5/NEU1/CLN5/ABCA5/CLN3/AP3B1/AP3M1/BLOC1S4/LAMTOR3/TFEB/SLC36A4/RRAGB/CTBS/ENTPD4/WDR7/LAPTM5/LAPTM4B/GALC/AP1G2/SNAPIN/AP5M1/GPR155/ABCA2/KXD1/MTOR	0.412687753892407
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/2075	18/9376	1.25515394912985	MMADHC/LMBRD1/ZNF143/HCFC1/THAP11	0.577631064422935
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/2075	36/9376	1.12963855421687	GALNT3/C1GALT1/GCNT1/GALNT11/GALNT10/B4GALT5/GALNT1/C1GALT1C1/GALNT2	0.415446883782915
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	13/2075	54/9376	1.08780008924587	PRF1/CTLA4/HLA-F/HLA-B/FAS/FASLG/GZMB/HLA-A/CD28/HLA-DQA2/CD80/CGA/CD40LG	0.344937810598451
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	42/2075	183/9376	1.03704523010073	NOP58/XPO1/XRN1/WDR43/SBDS/NXT1/HEATR1/RAN/RIOK2/UTP6/BMS1/NOP10/CSNK2A1/XRN2/NOP56/POP5/GNL3L/NMD3/GTPBP4/WDR36/NAT10/NXF1/LSG1/NOB1/REXO1/UTP18/EFL1/GNL3/RPP30/IMP3/RRP7A/RIOK1/MDN1/RPP38/NVL/RCL1/UTP14A/CSNK2A2/PWP2/RBM28/WDR75/WDR3	0.269794272658018
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/2075	59/9376	1.07219930569737	PRKACB/GNAI3/PIK3CD/PIK3CA/ADRB1/ABHD5/AKT1/ADCY7/ADCY3/PIK3R1/PDE3B/ADRB2/GNAS/CGA	0.296568140263019
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	42/2075	184/9376	1.03140911471975	SRGAP3/CXCR4/RAC2/SEMA4D/KRAS/PLCG2/CDC42/PPP3CA/GNAI3/MAPK1/PPP3CC/NCK1/MYL12A/SSH2/LRIG2/PRKCA/PIK3CD/CAMK2D/PIK3CA/PAK2/PPP3R1/MYL12B/ROCK1/NFATC3/NCK2/PLCG1/SRGAP2/RYK/PPP3CB/PARD6B/RAF1/PLXNA3/ARHGEF12/SEMA4F/NFATC2/PIK3R1/EPHB6/RASA1/FYN/RGS3/PLXNC1/PDPK1	0.22938399590741
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/2075	33/9376	1.09540708287696	PDHA1/DLD/IDH3A/DLST/IDH1/BCKDHB/PDHB/BCKDHA	0.292683289371796
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/2075	42/9376	1.0758462421113	MAP1LC3B/SLC3A2/VDAC3/VDAC2/ATG5/ACSL3/LPCAT3/PRNP/ACSL4/SAT2	0.262620321987893
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/2075	78/9376	1.04274328081557	ITGA4/IFNGR1/STAT1/NFKB1/MAPK1/JAK1/MARCKSL1/TRAF6/NCF4/MAPK13/IFNG/MAP3K7/RELA/ELK1/IRAK4/HLA-DQA2/JUN/TAB1	0.202080263202475
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	34/2075	150/9376	1.02420562248996	CDKN1B/CTNNB1/KRAS/CSNK1A1/LEF1/MAPK1/RPS6KB1/SOS2/BCL2/PIK3CD/GADD45A/PIK3CA/TGFBR2/MAP2K2/SOS1/ABCB1/MLH1/TCF7/MAP2K1/RB1/SMAD4/GRB2/AKT1/CDKN2B/BAK1/RAF1/DDB2/E2F3/APC/BRAF/AXIN1/PIK3R1/FRAT2/MTOR	0.159315736155589
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	81/2075	362/9376	1.01105771150902	CDKN1B/BCL2L11/PPP2R5C/HSP90AB1/HSP90AA1/GNG2/ITGA4/CCND3/KRAS/PPP2R5A/THEM4/CCND2/PTEN/NFKB1/MAPK1/MCL1/JAK3/IL2RB/RPS6KB1/SOS2/MDM2/PPP2R2A/BCL2/PPP2R3C/PPP2CA/RBL2/PRKCA/PIK3CD/PIK3CG/JAK1/PIK3CA/ATF2/MYB/CDC37/YWHAZ/PKN2/MAP2K2/LPAR6/SOS1/IKBKB/ATF6B/FASLG/EIF4B/IL4R/EIF4E/CREB1/PPP2R2D/PRKAA1/MAP2K1/ITGB7/GNG5/RHEB/GRB2/AREG/PPP2R2B/COL9A2/AKT1/KIT/YWHAB/CSF1/TSC2/GNB5/FLT3LG/IL2RG/RELA/RAF1/OSM/STK11/CHUK/IL2RA/PIK3R6/PIK3R1/LPAR2/GNG10/PDGFA/GNGT2/CDK6/DDIT4/TSC1/PDPK1/MTOR	0.114383736192942
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	25/2075	110/9376	1.02694414019715	MAPK1/RPS6KB1/EP300/SKIL/LEMD3/PPP2CA/NCOR1/SIN3A/SKI/SMAD7/SKP1/TGFBR2/TGIF2/RBL1/CUL1/ROCK1/ID2/SMAD4/TFDP1/IFNG/HDAC1/CDKN2B/E2F4/ZFYVE16/SMURF2	0.151536774422663
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/2075	30/9376	1.05432931726908	PIGS/PIGG/PGAP1/PIGF/PIGC/PIGH/PIGA	0.158885952191846
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/2075	30/9376	1.05432931726908	NFKB1/IKBKB/ABCC1/RELA/CHUK/GART/ATIC	0.158885952191846
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2075	12/9376	1.12963855421687	NCAM1/CD46/SLAMF1	0.239550793607063
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/2075	49/9376	1.01436931399066	PRKACB/GNAI3/NFKB1/ATF2/ATF6B/CREB1/RGS9/RELA/FOSB/GNAS/JUN	0.0537609087214575
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/2075	154/9376	0.997602879048662	PRKACB/PPP1CB/PPP2R5C/PPP2R5A/GNAI3/MAPK1/PPP1CC/PPP2R2A/BCL2/PPP2R3C/PPP2CA/PRKCA/PIK3CG/CAMK2D/ATF2/ADRB1/ATP2A2/ATP1A1/CALM1/ATF6B/PLCB2/MAPK13/CREB1/PPP2R2D/RPS6KA5/PPP2R2B/AKT1/ADCY7/CALM2/PIK3R6/ADCY3/ADRB2/PLCB1/GNAS	-0.0159897349095128
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2075	31/9376	1.02031869413136	PFKP/TKT/RPIA/PGM2/TALDO1/GLYCTK/PRPS1	0.0604074497446264
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/2075	31/9376	1.02031869413136	PGP/DLD/CAT/MDH1/AMT/ACAT2/GLYCTK	0.0604074497446264
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/2075	54/9376	1.00412315930388	AMD1/MAT2A/DNMT3A/MAT2B/LDHB/MRI1/DNMT1/MTAP/PSAT1/LDHA/MDH1/APIP	0.0161985432503035
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/2075	45/9376	1.00412315930388	TAP1/ABCG1/TAP2/ABCB1/ABCB7/ABCC1/ABCA5/ABCD2/ABCD3/ABCA2	0.0147800461921028
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2075	27/9376	1.00412315930388	HMGCS1/OXCT1/L2HGDH/BDH1/HADH/ACAT2	0.011437548044616
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/2075	101/9376	0.984239532386974	PRKACB/CTNNB1/KRAS/GNAI3/LEF1/MAPK1/EP300/PRKCA/CAMK2D/MAP2K2/CALM1/PLCB2/CREB1/TCF7/MAP2K1/KIT/ADCY7/RAF1/CALM2/ADCY3/PLCB1/GNAS	-0.0848938717958498
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/2075	18/9376	1.00412315930388	ACACA/ACSL3/ACSL4/ACSF3	0.0093342270641271
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/2075	18/9376	1.00412315930388	MAN2B1/MANBA/NEU1/NEU3	0.0093342270641271
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	34/2075	157/9376	0.978540403652828	MOB1A/PPP1CB/CTNNB1/CCND3/CCND2/LEF1/PPP1CC/PPP2R2A/BIRC2/PPP2CA/RASSF1/CSNK1D/SMAD7/TGFBR2/YWHAZ/PATJ/TP53BP2/LLGL2/DLG3/PPP2R2D/ID2/TCF7/LATS1/SMAD4/BBC3/AREG/PPP2R2B/BIRC3/YWHAB/PARD6B/BTRC/APC/DLG1/AXIN1	-0.144554954683196
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	49/2075	226/9376	0.979686533745602	PRKACB/PPP1CB/RAC2/ORAI1/GNAI3/NFKB1/MAPK1/RAP1A/RAP1B/EP300/PPP1CC/PDE4B/PTGER2/VAV3/PIK3CD/CAMK4/CAMK2D/PIK3CA/ADRB1/VAV1/MAP2K2/ATP2A2/ATP1A1/CALM1/CREB1/ROCK1/MAP2K1/MAPK8/ACOX1/PPP1R12A/AKT1/ADCY7/RELA/RAF1/CALM2/BRAF/MAPK9/NFATC1/ADCY3/PIK3R1/PDE3B/RRAS2/ADRB2/GNAS/JUN/CGA/AFDN/ACOX3/TIAM1	-0.164790140501372
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/2075	37/9376	0.976984695538912	UGP2/PGM2/UXS1/GALT/GALK2/UAP1/TGDS/GALE	-0.074777495131414
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/2075	65/9376	0.973227062094532	LPIN2/DGKZ/DGKD/DGKA/LPIN1/DGKE/AGPAT5/ALDH3A2/ALDH9A1/MBOAT1/AGK/AGPAT2/GLYCTK/AGPAT3	-0.11546704729233
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	25/2075	116/9376	0.973826339842127	GLS/PRKACB/GNG2/SLC38A1/PPP3CA/GNAI3/MAPK1/PPP3CC/SLC38A2/PRKCA/PLCB2/PPP3R1/ITPR1/GRK2/GNG5/PPP3CB/GNB5/ADCY7/ITPR3/ADCY3/GNG10/PLCB1/GNAS/GNGT2/ITPR2	-0.151213816576884
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/2075	98/9376	0.968261617900172	PRKACB/PRKD3/ORAI1/PRKCA/CAMK4/CAMK2D/ATF2/ATP1A1/CALM1/ATF6B/PLCB2/CREB1/ITPR1/ATF1/ADCY7/CALM2/ITPR3/ADCY3/PLCB1/GNAS/ITPR2	-0.168373660065506
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2075	28/9376	0.968261617900172	B3GNT2/B4GALT1/B4GALT4/B4GALT3/B3GNT5/GCNT2	-0.0896619051619408
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/2075	38/9376	0.951274571972099	UGP2/PGM2/UXS1/GALT/GALK2/UAP1/GALE/GNPDA2	-0.160444206926566
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/2075	38/9376	0.951274571972099	KRAS/MAPK1/PRKCA/PIK3CD/PIK3CA/ATP1A1/PIK3R1/PDPK1	-0.160444206926566
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/2075	76/9376	0.951274571972099	PRKACB/GNAI3/PRKCA/CAMK2D/ATP1A1/CALM1/PLCB2/ITPR1/EZR/ADCY7/CALM2/ITPR3/ADCY3/PLCB1/GNAS/ITPR2	-0.227365464860356
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/2075	20/9376	0.903710843373494	UGP2/UAP1/TGDS/CYB5R4	-0.229800404394527
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/2075	78/9376	0.926882916280507	CTNNB1/CDC42/HCLS1/ARPC5L/ACTR2/ACTR3/PIK3CD/ARPC1B/PIK3CA/CBL/DNM2/CD2AP/ARPC3/ACTR3C/CRKL/PIK3R1	-0.345680519621002
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/2075	50/9376	0.903710843373494	AMD1/ODC1/LAP3/CNDP2/ARG2/OAT/SAT2/ALDH3A2/ALDH9A1/P4HA1	-0.363930281985613
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/2075	65/9376	0.903710843373494	PRKACB/ORAI1/ATF2/ATF6B/PLCB2/CREB1/ITPR1/ADCY7/ITPR3/ADCY3/PLCB1/GNAS/ITPR2	-0.415278466681112
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/2075	21/9376	0.860676993689042	CSGALNACT2/CHST12/CHST11/B3GALT6	-0.340732926255906
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/2075	42/9376	0.860676993689042	DLD/CAT/GCDH/DLST/ALDH3A2/ALDH9A1/HADH/ACAT2	-0.482410884958699
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2075	32/9376	0.847228915662651	PFKP/UGP2/B4GALT1/PGM2/GALT/GALE	-0.461480388900921
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/2075	144/9376	0.909986613119143	CTNNB1/KRAS/JARID2/STAT3/MAPK1/JAK3/PCGF5/SKIL/KAT6A/PIK3CD/SMARCAD1/JAK1/PIK3CA/MAP2K2/RIF1/MAPK13/ID2/TCF7/MAP2K1/SMAD4/GRB2/TCF3/AKT1/RAF1/APC/AXIN1/PIK3R1/PCGF6/SETDB1	-0.580288502241725
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2075	22/9376	0.821555312157722	CNDP2/CARNMT1/ALDH3A2/ALDH9A1	-0.446703953343411
Organismal Systems	Digestive system	hsa04970	Salivary secretion	18/2075	93/9376	0.874558880684026	PRKACB/VAMP2/CD38/PRKCA/ADRB1/ATP1A1/CALM1/PLCB2/ITPR1/PRH1/ADCY7/CALM2/ITPR3/ADCY3/ADRB2/PLCB1/GNAS/ITPR2	-0.648098078935517
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/2075	23/9376	0.785835515976951	GLS/GLUD1/ATP1A1/MDH1	-0.548200486428788
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	17/2075	89/9376	0.863094625693786	GLS/PRKACB/GNG2/SLC38A1/GNAI3/SLC38A2/PRKCA/NSF/GABARAPL2/GNG5/GNB5/ADCY7/GABARAPL1/ADCY3/GNG10/GNGT2/GPHN	-0.691801169758618
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/2075	138/9376	0.88406495547407	CYCS/ATP6V0E2/NDUFV2/SDHD/NDUFB8/ATP5F1C/SDHA/COX11/NDUFB5/NDUFA5/ATP6V1H/ATP6V1G1/NDUFC2/UQCRFS1/UQCRH/NDUFB3/UQCRC2/NDUFA7/COX7A2L/ATP5MC3/TCIRG1/COX7B/COX10/COX7A2/NDUFA8/NDUFA9/COX7C	-0.73142333523432
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/2075	134/9376	0.876734400287718	PRKACB/PPP1CB/ARHGEF1/MAPK1/PPP1CC/PRKCH/PRKCA/PRKCQ/GNA13/MAP2K2/CALM1/PLCB2/ROCK1/MAP2K1/ITPR1/PPP1R12A/ADCY7/RAF1/CALM2/ARHGEF12/BRAF/ITPR3/ADCY3/PLCB1/GNAS/ITPR2	-0.766151797042979
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/2075	50/9376	0.813339759036145	CXCR4/ITGA4/ICOS/CD28/ITGB7/HLA-DQA2/MAP3K14/CD80/CD40LG	-0.705492876970308
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/2075	86/9376	0.840661249649762	PRKACB/VAMP2/PRKCA/CAMK2D/ATF2/ATP1A1/ATF6B/PLCB2/CREB1/ADCY7/STX1A/ITPR3/ADCY3/PLCB1/KCNN1/GNAS	-0.791345778496644
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/2075	91/9376	0.844125513041176	PRKACB/GNG2/PDE7A/GNAI3/PDE4B/PRKCA/ARRB2/GRK2/GNG5/GRK6/GNB5/ADCY7/ADCY3/PDE3B/GNG10/GNAS/GNGT2	-0.796541291128903
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/2075	41/9376	0.771460476050544	BPGM/ALAS1/DLD/PSAT1/AMT/DMGDH/GLYCTK	-0.781807081918831
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/2075	37/9376	0.732738521654184	PRKCA/FAS/PLCB2/FASLG/IFNG/PLCB1	-0.868341495529989
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/2075	149/9376	0.849124282364357	PRKACB/GNG2/GNAI3/MAPK1/NDUFV2/NDUFB8/PRKCA/NDUFB5/NDUFA5/NDUFC2/PLCB2/MAPK13/NDUFB3/MAPK8/ITPR1/GNG5/NDUFA7/GNB5/ADCY7/ITPR3/MAPK9/ADCY3/NDUFA8/GNG10/PLCB1/GNGT2/NDUFA9/ITPR2	-0.989659361676233
NA	NA	hsa03272	Virion - Hepatitis viruses	8/2075	48/9376	0.753092369477912	PDCD6IP/CHMP7/IST1/OCLN/VPS4A/TSG101/CHMP4A/DPP4	-0.914248752086907
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	21/2075	115/9376	0.825127291775799	CASP3/PRKACB/GNG2/KRAS/GNAI3/MAPK1/PRKCA/DUSP1/PLCB2/MAP2K1/ITPR1/GNG5/GNB5/RAF1/BRAF/ITPR3/GNG10/PLCB1/GNAS/GNGT2/ITPR2	-1.00587850702053
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	18/2075	100/9376	0.813339759036145	CXCR4/IL10RA/IL18R1/IL2RB/XCL1/IL18RAP/XCL2/TNFRSF10A/CCR5/CSF1/IL2RG/IL10RB/CCR7/IL2RA/CCL5/CCR1/CCR4/CCR2	-1.00040295677381
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/2075	100/9376	0.813339759036145	ITGA4/CD38/CD7/CD2/IL4R/CD55/CD37/CD3G/KIT/CD3E/CSF1/CD8B/CD44/FLT3LG/CD8A/HLA-DQA2/IL2RA/CD5	-1.00040295677381
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/2075	15/9376	0.602473895582329	ACP1/NTPCR	-0.821398062726722
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/2075	76/9376	0.77291058972733	HMGCS1/ACADM/DBI/ACSL3/ACOX1/ACSL4/SLC27A2/FABP5/SCP2/PPARD/PDPK1/UBC/ACOX3	-1.05965799421903
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/2075	67/9376	0.741852184858838	BPGM/PFKP/PDHA1/DLD/PGK1/LDHB/PGM2/ALDH3A2/ALDH9A1/LDHA/PDHB	-1.13046690951509
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	28/2075	154/9376	0.821555312157722	GCH1/MAT2A/MTHFD2/UGP2/ALAS1/DLD/PANK3/RDH11/CTPS1/CMPK1/PHOSPHO2/MAT2B/PANK2/GGCX/PPCS/COX10/FLAD1/ALDH3A2/MTHFD1/PSAT1/MOCS2/ADSL/NADSYN1/RDH13/DHODH/CMPK2/GPHN/CPOX	-1.19029590601863
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/2075	23/9376	0.589376636982713	GLS/GLUD1/ARG2	-1.0510796333573
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/2075	52/9376	0.69516218721038	MYLIP/VAPA/VDAC3/VDAC2/CIDEB/STARD3NL/LDLRAP1/STARD3	-1.17509476308845
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/2075	17/9376	0.531594613749114	SCP2/ACOT8	-1.03046947627408
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/2075	17/9376	0.531594613749114	SEPHS2/PAPSS1	-1.03046947627408
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/2075	17/9376	0.531594613749114	CA5B/GLUD1	-1.03046947627408
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/2075	17/9376	0.531594613749114	PCDH11X/PCDH9	-1.03046947627408
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/2075	10/9376	0.451855421686747	PAPSS1	-0.924531176248214
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/2075	53/9376	0.682045919527165	PRKACB/PRKCA/DNM2/ATP1A1/PLCB2/PLCB1/GNAS/VDR	-1.23745099749613
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/2075	36/9376	0.627576974564926	UGP2/PGM2/PGM2L1/GYG1/PYGB	-1.19348743358537
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/2075	75/9376	0.722968674698795	MAT2A/PFKP/PGK1/IDH3A/TKT/ARG2/MAT2B/RPIA/TALDO1/IDH1/PSAT1/PRPS1	-1.28409810089036
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/2075	48/9376	0.658955823293173	PIK3CD/PIK3CA/ATP1A1/PLCB2/AKT1/PIK3R1/PLCB1	-1.26281724182206
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/2075	12/9376	0.376546184738956	GGCX	-1.15204043369146
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	60/2075	323/9376	0.83935991644597	GLS/CASP3/SOCS1/EZH2/ATM/CDKN1B/BCL2L11/PIM1/KRAS/PLCG2/STAT3/MDM4/SIRT1/CCND2/PTEN/NFKB1/MAPK1/MCL1/SOS2/EP300/MDM2/ZEB2/PDCD4/BCL2/HNRNPK/RASSF1/DNMT3A/PRKCA/PIK3CD/UBE2I/PIK3CA/CCNG1/MAP2K2/SOS1/ABCB1/IKBKB/ROCK1/MAP2K1/RPS6KA5/PLCG1/GRB2/HDAC1/EZR/CD44/ABCC1/STMN1/BAK1/RAF1/CRKL/DNMT1/E2F3/APC/PIK3R1/SLC7A1/BMF/PDGFA/CDK6/DDIT4/MTOR/NOTCH1	-1.56625487891141
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/2075	63/9376	0.645507745266781	CTNNB1/LEF1/GADD45A/TCF7/BAK1/DDB2/APC/PTCH2/AXIN1	-1.50499736141192
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/2075	102/9376	0.708792818332152	RAP1A/CD38/RAP1B/RAB8A/PRKCA/ATP2A2/ATP1A1/PLCB2/ITPR1/ADCY7/ITPR3/ADCY3/PLCB1/GNAS/ITPR2/RAB27B	-1.57642072492291
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/2075	160/9376	0.762506024096386	PTPRC/NCAM1/ITGA4/CD58/CTLA4/HLA-F/CD2/HLA-B/ICAM3/ICOS/SELL/SELPLG/TIGIT/OCLN/HLA-A/CD28/ITGB7/SPN/CD226/CD8B/CD8A/CD99/HLA-DQA2/PDCD1/SDC4/CD80/CD40LG	-1.61526904709364
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/2075	52/9376	0.608266913809082	PRKACB/HSD17B7/ADCY7/ADCY3/GNAS/CGA/ACOT2	-1.51006036258734
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/2075	28/9376	0.484130808950086	GCH1/MOCS2/GPHN	-1.45734632403128
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/2075	28/9376	0.484130808950086	ATP6V0E2/ATP6V1G1/TCIRG1	-1.45734632403128
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/2075	59/9376	0.612685317541352	ODC1/LAP3/GSR/TXNDC12/IDH1/GGCT/GSTM2/GSTM4	-1.59094597882697
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/2075	35/9376	0.516406196213425	PFKP/PFKFB3/TIGAR/KHK	-1.52799375168643
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/2075	29/9376	0.467436643124221	MOB1A/RASSF1/LATS1	-1.53122028391218
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2075	29/9376	0.467436643124221	CALM1/RGS9/CALM2	-1.53122028391218
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	33/2075	195/9376	0.764678405931418	RAC2/PLCG2/CASP1/CASP4/NFKB1/MAPK1/HAT1/VDAC3/PRKCA/PIK3CD/VDAC2/SLC25A5/PIK3CA/SELPLG/MAP2K2/HDAC9/NCF4/PLCB2/MAPK13/MAP2K1/HMGB1/HDAC3/PLCG1/GSDMD/HDAC1/AKT1/MAP3K7/RELA/RAF1/PIK3R1/HDAC8/PLCB1/MTOR	-1.77026224914819
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/2075	95/9376	0.665892200380469	ATP6V0E2/CTLA4/ATP6V1H/ATP6V1G1/CD28/TCIRG1/IFNG/CSF1/IL23A/HLA-DQA2/TNFSF11/CCL5/CD80/JUN	-1.74483572618173
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/2075	23/9376	0.392917757988476	B4GALT1/B4GALT3	-1.55395878028581
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/2075	23/9376	0.392917757988476	LNPEP/PREP	-1.55395878028581
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/2075	15/9376	0.301236947791165	ST6GALNAC6	-1.443836294047
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/2075	37/9376	0.488492347769456	GLS/GLUD1/PPAT/ADSL	-1.66190549592856
NA	NA	hsa04981	Folate transport and metabolism	3/2075	31/9376	0.437279440342013	MTHFS/ABCC1/MTHFD1	-1.67296745096116
Cellular Processes	Cell motility	hsa04814	Motor proteins	32/2075	194/9376	0.745328530617315	BICDL1/DYNLT1/KIF2A/CAPZA1/MYL12A/TUBA1A/CAPZA2/DYNLT3/TUBA4A/MYO9B/DCTN4/MYO7A/STARD9/MYL12B/DYNLL2/MYO1F/TUBB2A/MYO1G/TUBD1/KIF18A/KIF5B/DCTN6/KIF20B/KIF13B/KIF11/KLC1/ACTR10/KIF3A/DYNLL1/TUBE1/KIF5C/MYO9A	-1.91080350534299
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/2075	103/9376	0.658041876242835	CASP3/PRKACB/NFKB1/PRKCA/PIK3CD/PIK3CA/PLCB2/RAB5A/ARG2/IFNG/RELA/SERPINB9/PIK3R1/PLCB1/GNAS	-1.86030829477161
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/2075	24/9376	0.376546184738956	B3GALT6/HS3ST3B1	-1.63027614300704
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/2075	51/9376	0.531594613749114	PAFAH1B1/AGPS/SELENOI/LPCAT4/CEPT1/PAFAH1B2	-1.78807636533788
Human Diseases	Substance dependence	hsa05034	Alcoholism	31/2075	191/9376	0.733377909543935	PRKACB/PPP1CB/GNG2/KRAS/GNAI3/MAPK1/HAT1/SOS2/PPP1CC/CAMK4/ATF2/SOS1/CALM1/HDAC9/ATF6B/PKIA/CREB1/MAP2K1/HDAC3/GNG5/GRB2/HDAC1/GNB5/RAF1/FOSB/CALM2/BRAF/HDAC8/GNG10/GNAS/GNGT2	-1.98461718210484
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/2075	17/9376	0.265797306874557	CSAD	-1.61521085553607
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2075	26/9376	0.34758109360519	ACOX1/ACOX3	-1.77586897888259
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/2075	26/9376	0.34758109360519	LMBRD1/ABCC1	-1.77586897888259
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/2075	61/9376	0.518522615050365	TRPM7/MT1F/MT2A/MT1X/ATP1A1/ATP7A/VDR	-2.01118904839844
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/2075	19/9376	0.237818642993025	IDS	-1.77284318381772
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/2075	82/9376	0.55104319717896	HPRT1/UPP1/DPYD/CMPK1/GMPS/DUT/CDADC1/UCKL1/GSTM2/GSTM4	-2.17677561269038
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	41/2075	254/9376	0.729372924769946	CXCR4/PRKACB/PLCG2/PPP3CA/ORAI1/STIM2/PPP3CC/CD38/VDAC3/STIM1/PRKCA/VDAC2/CAMK4/CAMK2D/SLC25A5/ADRB1/ATP2A2/CALM1/PLCB2/SPHK2/PPP3R1/PHKB/ITPR1/NFATC3/PLCG1/PPP3CB/ADCY7/CYSLTR1/CALM2/TFEB/RYR1/ITPR3/NFATC1/NFATC2/MCU/ADCY3/ADRB2/PLCB1/PDGFA/GNAS/ITPR2	-2.33102312963772
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/2075	155/9376	0.641343179168286	TAP1/CALR/ATP6V0E2/SEC22B/HLA-F/HLA-B/TUBA1A/ATP6V1H/M6PR/TAP2/TUBA4A/ATP6V1G1/STX12/NCF4/RAB5A/HLA-A/SEC61B/TUBB2A/TCIRG1/PIK3C3/CORO1A/HLA-DQA2	-2.40026640768531
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/2075	79/9376	0.514771999389965	VAMP2/ATP6V0E2/ATP6V1H/ATP6V1G1/DNM2/NSF/TCIRG1/STX3/STX1A	-2.30882756615899
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/2075	31/9376	0.291519626894675	ALDH3A2/ALDH9A1	-2.10631117613761
Human Diseases	Immune disease	hsa05310	Asthma	2/2075	32/9376	0.282409638554217	HLA-DQA2/CD40LG	-2.1676476311466
NA	NA	hsa04518	Integrin signaling	21/2075	154/9376	0.616166484118291	RAC2/CTNNB1/ITGA4/CCND3/CDC42/CCND2/ITGAE/ARHGEF6/FERMT3/ICAM3/PIK3CD/PIK3CA/PARVG/ITGB7/NCK2/ITGAX/COL9A2/AKT1/PIK3R1/PDGFA/MTOR	-2.56031977231261
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/2075	50/9376	0.361484337349398	GYPC/IFNG/KLRK1/CD40LG	-2.41330585189378
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/2075	87/9376	0.467436643124221	ATP2A2/UQCRFS1/ATP1A1/UQCRH/UQCRC2/COX7A2L/COX7B/COX7A2/COX7C	-2.66041838742175
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/2075	46/9376	0.294688318491357	ALAS1/COX10/CPOX	-2.55636395454455
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/2075	86/9376	0.420330624824881	CTNNB1/ITGA4/LEF1/ATP2A2/TCF7/ITGB7/SNTB1/SNTB2	-2.87889111694626
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	44/2075	298/9376	0.667169079000566	CXCR4/IFNGR1/IL10RA/IL18R1/IL2RB/IL16/RELT/IL27RA/TNFRSF9/XCL1/IL18RAP/TNFRSF18/TGFBR2/XCL2/TNFRSF10A/CCR5/FAS/TNFSF12/FASLG/IL4R/IL12RB2/TNFSF9/IFNG/TNFSF4/CXCR6/CSF1/TNFRSF25/IL23A/IL2RG/IL10RB/CCR7/CD27/OSM/IL12RB1/IL2RA/TNFSF11/TNFSF8/CCL5/CCR1/CCR4/TNFRSF4/IL21R/CCR2/CD40LG	-3.1127212038452
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/2075	43/9376	0.21016531241244	AGPAT2/ACAT2	-2.767345045234
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/2075	90/9376	0.401649263721553	PRKACB/ATP1A1/ABCB1/HMGCR/ADCY7/ADCY3/SLC51A/GNAS	-3.04064878616634
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/2075	105/9376	0.430338496844521	PRKACB/ITGA4/ADRB1/ATP2A2/ITGB7/SNTB1/ADCY7/SNTB2/ADCY3/GNAS	-3.12933274818039
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/2075	63/9376	0.286892331229681	PTGES3/PTGES2/LTA4H/EPHX2	-3.02749960139359
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/2075	36/9376	0.125515394912985	UGP2	-2.80242175095365
NA	NA	hsa04519	Cadherin signaling	58/2075	404/9376	0.648703328164142	MOB1A/EVL/PPP1CB/RAC2/KRT81/SHOC2/CTNNB1/KRAS/CSNK1A1/CDC42/NFKB1/LEF1/MAPK1/ARPC5L/KRT86/EP300/PPP1CC/ACTR2/ERBIN/ACTR3/VAV3/NCKAP1L/VASP/TMC6/ADAM10/ARPC1B/VAV1/YWHAZ/MAP2K2/KRT10/IKBKB/MYO7A/PCDH11X/MAPK13/PCDH9/CYFIP2/ROCK1/TCF7/MAP2K1/MAPK8/MYO1F/LATS1/MYO1G/TMC8/YWHAB/RYK/ARPC3/PSEN1/ACTR3C/MAP2K3/RELA/RAF1/APC/MAPK9/CHUK/AXIN1/RRAS2/AFDN	-3.84789843135521
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/2075	89/9376	0.304621632597807	ITGA4/CD47/ITGB7/COL9A2/CD44/SDC4	-3.51383990899941
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/2075	66/9376	0.20538882803943	HSD17B11/HSD17B7/HSD17B12	-3.45346698541849
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/2075	99/9376	0.319493732505781	ITGA4/ATP2A2/PRKAA1/ITGB7/SNTB1/SNTB2/PRKAG2	-3.62868661647224
NA	NA	hsa04081	Hormone signaling	25/2075	219/9376	0.515816691423227	PRKACB/GNG2/STAT3/GNAI3/PIK3CD/PIK3CA/GNA13/ADRB1/PLCB2/ADIPOR2/SMAD4/GNG5/STAT5B/GNB5/ADCY7/STK11/ADCY3/PIK3R1/GNG10/ADRB2/PLCB1/GNAS/GNGT2/GNRH1/CGA	-3.86508259129202
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/2075	86/9376	0.262706640515551	PRKACB/PLCB2/ITPR3/PLCB1/TAS2R4	-3.66172061886486
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/2075	103/9376	0.263216750497134	SLC3A2/SLC38A2/ATP1A1/COL9A2/SLC36A4/DPP4	-4.00822175370309
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/2075	68/9376	0.132898653437279	RDH11/RDH13	-3.82560075260353
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/2075	88/9376	0.20538882803943	CD46/CD55/ITGAX/F5	-3.99244014617075
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/2075	70/9376	0.129101549053356	GSTM2/GSTM4	-3.8988679687589
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/2075	73/9376	0.123796005941574	GSTM2/GSTM4	-4.00644017920102
NA	NA	hsa04082	Neuroactive ligand signaling	17/2075	199/9376	0.386007144154507	PRKACB/GNG2/GNAI3/PRKCA/OGFR/ADRB1/PLCB2/GNG5/GNB5/ADCY7/ADCY3/GNG10/ADRB2/PLCB1/P2RY11/GNAS/GNGT2	-4.6670559220803
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/2075	233/9376	0.426644604167744	LBR/SPTAN1/ITGA4/SYNE1/CAPZA1/LMNB1/TMOD3/DIAPH1/CAPZA2/LMOD3/SYNE3/ATP1A1/TMEM43/ITGB7/SNTB1/FMNL1/COL9A2/FMNL3/SNTB2/AMPD2/SYNE2/SDC4	-4.72455619686044
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/2075	79/9376	0.114393777642214	GSTM2/GSTM4	-4.21392017025181
NA	NA	hsa04382	Cornified envelope formation	18/2075	217/9376	0.374810948864583	PPP2R5C/KRT81/PPP2R5A/KRT86/PPP2R2A/UGCG/PPP2R3C/PPP2CA/KRT10/SPTLC2/OCLN/PPP2R2D/SPTLC1/PPP2R2B/ABHD5/BLMH/FURIN/EPHX2	-4.96730372394982
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/2075	143/9376	0.252786249894684	SSB/TRIM21/CD28/IFNG/SNRPB/HLA-DQA2/CD80/CD40LG	-4.80004126093819
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/2075	99/9376	0.13692588535962	SELPLG/KRT10/HLA-DQA2	-4.60219933072957
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/2075	370/9376	0.232033865190492	GZMA/PTGER4/P2RY10/S1PR4/PTGER2/OGFR/ADRB1/LPAR6/PTGDR/CYSLTR1/NR3C1/LPAR2/S1PR5/S1PR1/ADRB2/P2RY11/PAQR6/GNRH1/CGA	-8.03489997142721
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/2075	449/9376	0.100635951377895	PRKACB/OR11G2/NCALD/CAMK2D/OR2A25/ARRB2/CALM1/GRK2/CALM2/ADCY3	-10.4114073950251