category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	93/2395	158/9376	2.3042942839777	CUL1/CCND3/BUB3/MDM2/GADD45A/RBL2/PPP2R5A/ESCO1/CCNH/CDKN2C/CDC14A/CCND2/CDKN2D/EP300/TFDP1/HDAC1/WAPL/ANAPC5/ATM/BUB1/STAG2/WEE1/DBF4/CDC16/RB1/FZR1/CDKN1B/SMAD4/CDKN2A/PDS5B/PPP2CA/YWHAZ/ATR/ANAPC7/ANAPC4/RBL1/ORC4/MAD2L2/ANAPC16/STAG1/SMC3/MAD2L1BP/CDC26/SKP1/MAD2L1/CDC23/PRKDC/HDAC8/CDC27/CDK2/MCM4/ANAPC1/MCM3/ANAPC10/MCM6/GSK3B/RAD21/ORC2/PCNA/E2F4/TTK/TP53/CDK6/CCNB1/MCM5/DDX11/CDK7/SKP2/ATRX/CHEK1/CCNA2/E2F5/MAD1L1/ORC1/MCM2/CDC6/PTTG1/FBXO5/YWHAB/MTBP/CDC45/ORC5/NDC80/CCNB2/SGO1/KNL1/CDT1/CDCA5/ESCO2/PLK1/CDK1/BUB1B/CDC25C	9.68423591570883
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	69/2395	108/9376	2.50113662723266	DDX39B/XPO1/NUP54/KPNA4/SUMO1/KPNA2/NUP50/EIF4A3/MAGOH/RAN/THOC7/NMD3/PNN/RNPS1/ACIN1/NUP58/NUP98/NCBP1/IPO7/SUMO2/TNPO1/THOC3/PHAX/NXT1/SENP2/NUP153/KPNA1/KPNA3/THOC1/UBE2I/NCBP2/NXF1/XPOT/TNPO3/RANBP2/RAE1/NUP88/MAGOHB/NUP210/TMEM33/XPO4/SAP18/SEC13/NUP133/NUP214/RBM8A/IPO5/IPO11/SUMO4/NUP160/NUP107/NUP205/KPNA5/XPO5/NUP37/CSE1L/GLE1/NUP155/NUP35/IPO9/NUP43/NUP85/RANBP17/NXT2/THOC5/THOC6/IPO13/NDC1/IPO4	9.19006673271862
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	82/2395	142/9376	2.2606721750125	SOCS1/CUL1/MDM2/BIRC6/UBA2/CUL3/SMURF2/UBA6/UBE2S/UBE2Q2/TRIP12/UBE2J1/RNF7/UBE2A/UBE2F/UBE2N/BIRC2/CUL2/HERC2/ANAPC5/UBE2G1/ITCH/UBE3A/HERC4/UBE2B/CDC16/CUL5/UBE2H/FZR1/FBXW7/UBE2M/UBE2Q1/FANCL/MAP3K1/UBE2D2/UBE2L6/UBE4A/ANAPC7/UBE2E3/ANAPC4/UBE2I/HUWE1/PML/PPIL2/ANAPC16/UBE2Z/DDB2/VHL/UBA3/UBE2W/CDC26/SIAH1/SKP1/RCHY1/CDC23/CDC27/UBE2E1/UBE2J2/ANAPC1/UBE2D3/SYVN1/COP1/BIRC3/ANAPC10/UBE2O/CUL4B/UBA7/TRAF6/SKP2/TRIM37/BTRC/BRCA1/FBXW8/PRPF19/PIAS4/UBB/SMURF1/RHOBTB2/ERCC8/UBE2C/FBXO2/UBE3B	8.86606646200796
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	86/2395	174/9376	1.93491229333141	CUL1/HSPA5/HSPH1/HERPUD1/DDIT3/DNAJA2/HSPA8/DNAJB11/ERO1A/CALR/STT3B/EIF2S1/UBE2J1/HYOU1/FBXO6/ERO1B/PDIA6/RAD23B/PDIA3/DNAJC3/UBE2G1/DERL2/CAPN2/BCL2/HSPA1A/UBQLN1/XBP1/DERL1/SEC24D/DNAJC10/SAR1B/DDOST/DNAJB12/SAR1A/OSTC/UGGT1/HSP90AB1/PDIA4/TRAM1/BAG2/ATF6B/DAD1/ERN1/MOGS/UBE2D2/SSR2/SEC61B/DNAJA1/NGLY1/BAK1/SEC23B/MBTPS1/PLAA/BAX/SKP1/EIF2AK3/TMEM258/MAPK9/SEC23A/CAPN1/UBE2J2/UFD1/UBE2D3/SEC13/PREB/SYVN1/EDEM3/EDEM2/UBQLN2/SEC24A/EDEM1/HSP90AA1/SEC24B/HSPA1B/SEC61A2/MAPK8/ATXN3/YOD1/SEC61G/DERL3/MAN1B1/DNAJB1/HSPA6/TRAF2/HSPA4L/FBXO2	7.29094728454677
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	97/2395	214/9376	1.77447564045032	CUL1/BST2/APOBEC3G/CASP8/CASP3/B2M/TBK1/RAC2/GNAI3/CALR/TAP1/KRAS/AP1G1/PPP3CA/RNF7/MAPK1/AP1S3/BID/PPP3CC/CD3E/MAP2K3/ITPR1/PDIA3/CYCS/ATM/HLA-F/TRAF5/BCL2/APOBEC3C/WEE1/MAP2K1/MAP2K2/NFKB1/CUL5/GNG5/IRAK4/PTK2B/CASP9/RAF1/GNGT2/LIMK1/TRIM5/ATR/PIK3CA/APOBEC3H/BAK1/PXN/NRAS/TAP2/PPP3R1/HLA-B/BAX/SKP1/RPS6KB1/MAPK9/APOBEC3D/PIK3CD/CD247/FASLG/NFATC3/HLA-A/MYD88/CRKL/MAP2K6/AP1S1/RIPK1/CALM1/CALM3/AKT1/CHUK/IRAK1/MTOR/APOBEC3F/GNAI2/RPS6KB2/CCNB1/CGAS/MAPK8/CUL4B/TRAF6/IKBKB/CHEK1/TRADD/NFATC2/FADD/FAS/CFL1/BTRC/MAP3K7/TAB1/GNG10/CCNB2/TRAF2/CDK1/APOBEC3B/PIK3R1/CDC25C	6.71272851900915
Human Diseases	Infectious disease: viral	hsa05162	Measles	69/2395	136/9376	1.98619673339064	MX1/OAS2/CCND3/CASP8/CASP3/OAS1/IRF7/EIF2AK2/TBK1/HSPA8/EIF2S1/CCND2/BID/CD3E/CYCS/MSN/BCL2/HSPA1A/IL2RB/ADAR/NFKB1/STAT1/CDKN1B/STAT3/IRAK4/CASP9/CD46/EIF3H/JAK3/OAS3/PIK3CA/IRF9/BAK1/CSNK2A1/CSNK2A2/BAX/MAPK9/RCHY1/PIK3CD/MX2/FASLG/RAB9A/CDK2/MYD88/IL2RA/CSNK2B/APAF1/GSK3B/AKT1/CHUK/IRAK1/JAK1/HSPA1B/TP53/CDK6/MAPK8/TRAF6/IKBKB/BBC3/IL2RG/TRADD/TYK2/FADD/FAS/MAP3K7/HSPA6/TNFAIP3/PIK3R1/IKBKE	6.78541799671374
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	107/2395	248/9376	1.68905650212136	CASP8/CASP3/LEF1/ARPC5L/ARF6/IL18/ACTR3/CASP1/PIK3CG/DYNLT1/CYTH4/DYNLT3/PYCARD/CASP4/KPNA4/CTNNB1/RHOH/MAPK1/ACTR2/SNX18/MAP2K3/EXOC4/PTPRC/EXOC5/CDC42/BIRC2/ARPC1B/CYCS/TUBA4A/BCL2/RAB5A/FBXO22/ACBD3/MAP2K1/MAP2K2/NFKB1/ACTR10/ARPC3/MYL12A/HSP90AB1/IRAK4/RAF1/KPNA1/STX10/CYTH1/NCKAP1L/KPNA3/M6PR/PIK3CA/ARF1/TXN2/BAK1/ABI1/CYFIP2/MLKL/BAX/SKP1/DYNLL1/MAPK9/PLEKHM1/MYL12B/PIK3CD/ARL8B/EXOC2/RAB9A/VPS33A/BRK1/MYD88/ELMO2/MAP2K6/RIPK1/BIRC3/VPS41/MAP2K4/VPS11/CASP7/AKT1/CHUK/ARPC4/IRAK1/TNFRSF10A/HSP90AA1/DCTN6/TCF7/MAPK8/TRAF6/ARPC5/IKBKB/CYTH2/RIPK2/CSE1L/VPS39/TRADD/ARPC2/TNFRSF10B/TUBA1B/FADD/RHOA/MAP3K7/TAB1/ARHGEF26/RPS3/TRAF2/RILP/ACTR3C/PFN1/NOD1	6.44128385310065
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	75/2395	157/9376	1.87013815938194	CCND3/MDM2/GADD45A/RRAS2/PPID/RBL2/HIPK1/RBBP4/KRAS/CCND2/PPP3CA/MAPK1/PPP3CC/PPP1CB/VDAC2/VDAC3/MAP2K3/ITPR1/PPP1CC/RASSF5/HIPK3/ATM/CAPN2/HLA-F/SIRT1/RB1/MAP2K1/MAP2K2/NFKB1/TRPM7/VDAC1/RAF1/CDKN2A/ZFP36L2/PTEN/ATR/PIK3CA/RBL1/SLC25A5/NRAS/PPP3R1/HLA-B/KIR2DL4/PIK3CD/CAPN1/LIN54/NFATC3/CDK2/HLA-A/MAP2K6/CALM1/CALM3/HUS1/AKT1/RAD1/MTOR/E2F4/TP53/CDK6/CCNB1/RAD9A/TSC1/CHEK1/MRAS/CCNA2/RAD50/E2F5/NFATC2/BTRC/LIN9/ETS1/CCNB2/FOXM1/CDK1/PIK3R1	6.43984940532954
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	67/2395	137/9376	1.91454825289914	GZMB/CASP8/CASP3/GADD45A/BCL2L11/CASP10/DDIT3/PMAIP1/KRAS/EIF2S1/PARP4/MAPK1/BID/ITPR1/CTSW/CTSC/BIRC2/CYCS/ATM/TUBA4A/CAPN2/PRF1/BCL2/SPTAN1/MAP2K1/MAP2K2/NFKB1/MCL1/CASP9/RAF1/ERN1/PIK3CA/LMNB1/BAK1/NRAS/BAX/EIF2AK3/MAPK9/DFFA/PIK3CD/CAPN1/FASLG/AIFM1/RIPK1/BIRC3/APAF1/HTRA2/CASP7/AKT1/CHUK/TNFRSF10A/CASP6/TP53/CASP2/MAPK8/IKBKB/BBC3/PARP2/TRADD/TNFRSF10B/TUBA1B/FADD/FAS/PARP3/TRAF2/BIRC5/PIK3R1	6.31588192816075
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	82/2395	180/9376	1.78341916028764	OAS2/BST2/SRSF5/SRSF6/CASP8/CASP3/OAS1/B2M/ZC3HAV1/IRF7/EIF2AK2/TBK1/SP100/SYK/CALR/TAP1/SRSF9/SRSF2/EIF2S1/SRSF7/BID/PPP1CB/PPP1CC/BIRC2/PDIA3/CYCS/SRSF1/PILRB/HLA-F/TRAF5/BCL2/IFNGR1/NFKB1/STAT1/SRSF8/SRSF3/IRAK4/CASP9/SRSF4/OAS3/PIK3CA/IRF9/NXF1/PML/BAK1/TAP2/HLA-B/EIF2B1/BAX/EIF2B5/TNFSF14/PIK3CD/FASLG/HLA-A/MYD88/JAK2/SRPK1/BIRC3/APAF1/AKT1/NECTIN1/EIF2B3/CHUK/IRAK1/MTOR/JAK1/TP53/CGAS/TRAF6/IKBKB/TSC1/EIF2B2/TRADD/TYK2/HCFC2/FADD/FAS/MAP3K7/TAB1/TRAF2/PIK3R1/IKBKE	6.21599330913529
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	67/2395	138/9376	1.90067471483465	ARPC5L/TBK1/ARF6/RAC2/IL18/ACTR3/CASP1/ARHGEF12/PYCARD/ARHGEF1/LCP2/MAPK1/ACTR2/MAP2K3/SKAP2/CDC42/VAV3/ARPC1B/ZAP70/MAP2K1/MAP2K2/NFKB1/WIPF1/ARHGEF7/ARPC3/IRAK4/PTK2B/LIMK1/PKN2/WAS/RPS6KA3/PIK3CA/PXN/MAPK9/PIK3CD/VAV1/RPS6KA1/NFATC3/MYD88/CRKL/ELMO2/LAT/MAP2K6/ITGA4/MAP2K4/ROCK1/GSK3B/GIT2/AKT1/CHUK/ARPC4/IRAK1/PIP5K1A/MAPK8/TRAF6/ARPC5/IKBKB/ARPC2/NFATC2/RHOA/MAP3K7/TAB1/CD8A/TRAF2/ACTR3C/WIPF3/PIK3R1	6.24306868573943
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	44/2395	78/9376	2.20836143675392	HSPD1/DDX6/C1D/LSM5/HSPA9/XRN1/LSM8/DCP2/LSM1/LSM2/BTG3/PNPT1/CNOT7/MTREX/CNOT4/TENT4B/CNOT9/LSM6/CNOT2/ZCCHC7/LSM4/EXOSC6/PFKP/EXOSC5/XRN2/CNOT10/DCPS/MPHOSPH6/EXOSC1/EXOSC3/EXOSC8/LSM3/EXOSC7/EXOSC9/CNOT6/PAN3/EXOSC2/CNOT3/BTG2/PABPC1L/ENO1/TENT4A/BTG1/EDC4	6.27666522269771
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	53/2395	103/9376	2.01442325232584	DDX39B/CPSF6/PAPOLA/PPP2R5A/ETF1/WDR33/HBS1L/PPP1CB/PABPN1/EIF4A3/PPP1CC/MAGOH/GSPT1/RNMT/RNGTT/PNN/RNPS1/SMG1/ACIN1/PPP2R2A/FIP1L1/NCBP1/PPP2R2B/NXT1/PPP2CA/TARDBP/PELO/SSU72/NCBP2/NXF1/MSI2/PPP2R3C/NUDT21/MAGOHB/SMG7/CSTF3/CSTF1/SAP18/PAPOLG/CPSF7/RBM8A/PPP2R2D/CPSF1/DAZAP1/CSTF2/GSPT2/PABPC1L/CLP1/GLE1/CPSF3/NXT2/FUS/CPSF4	6.06327485817996
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	37/2395	63/9376	2.2991814958412	MNAT1/POLR2B/POLR2K/CCNH/GTF2H2/RAD23B/XPA/RPA2/POLR2H/POLR2C/POLR2F/RPA1/RFC1/POLR2J/DDB2/POLR2D/POLR2A/ERCC5/POLR2M/RFC2/GTF2H3/RFC4/GTF2H2C/GTF2H5/PCNA/RPA3/POLE2/CUL4B/GTF2H1/CDK7/ERCC3/ERCC4/RFC5/POLD4/ERCC8/POLR2J3/POLD1	6.06003144421631
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	141/2395	368/9376	1.49997276935645	HSPA5/PSMA2/CASP3/PSMD12/COX6A2/TBK1/DDIT3/CASP1/NDUFC2/HNRNPA2B1/CHCHD10/ATP5F1C/NUP54/UQCRC2/EIF2S1/MAP1LC3B/SRSF7/PSMA5/RAB8A/PPP3CA/NDUFB5/NDUFB3/BID/PPP3CC/MAP2K3/NUP50/NRBF2/CYCS/PSMA6/SDHD/SETX/TUBA4A/SPG11/UQCRFS1/BCL2/RAB5A/PSMD13/ATXN2L/UBQLN1/HNRNPA3/SDHA/XBP1/DERL1/PSMD6/NUP58/PSMA1/ATP5MC3/NDUFA9/NUP98/NDUFB8/NDUFA13/NCBP1/NDUFV2/NDUFS4/ACTR10/SRSF3/NDUFAB1/HNRNPA1/PSMB2/VDAC1/NXT1/PSMC4/SDHB/CASP9/COX5A/NDUFA10/TANK/NUP153/NDUFA2/PSMC6/WDR41/ERN1/TARDBP/ATP5MC1/NDUFA8/NDUFA6/COX7A2L/NXF1/NDUFA12/CAT/PSMA3/PPP3R1/RANBP2/RAE1/NDUFB6/NUP88/PSMD11/BAX/EIF2AK3/PSMB3/NUP210/ATP5F1A/OPTN/NDUFS3/COX7B/PSMC2/PSMD9/CYC1/SEC13/UQCR10/NDUFA7/NUP133/ATP5PO/NDUFB4/NUP214/COX7A2/UQCRH/MAP2K6/APAF1/UBQLN2/COX7C/NUP160/NUP107/MTOR/NUP205/DCTN6/TP53/ATG2B/SOD1/NUP37/PSMB1/GLE1/NUP155/COX6A1/NUP35/NUP43/DNAH14/TUBA1B/NUP85/ATP5MC2/NXT2/NDUFA4/FUS/PIK3R4/HDAC6/RAB39B/DNAL4/COX8A/TRAF2/NDC1/PFN1	5.73106916987158
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	88/2395	205/9376	1.68050919089567	OAS2/CCND3/CASP8/MDM2/CASP3/OAS1/PSMD12/B2M/GADD45A/IRF7/BCL2L11/EIF2AK2/TBK1/SYK/CALR/TAP1/CCND2/BID/CD58/CD3E/MAP2K3/HDAC1/PDIA3/CYCS/HLA-F/TRAF5/BCL2/PSMD13/RB1/PSMD6/NFKB1/STAT1/SNW1/CDKN1B/STAT3/IRAK4/PSMC4/CASP9/RUNX3/JAK3/OAS3/PSMC6/USP7/PIK3CA/IRF9/BAK1/TAP2/SAP30/DDB2/HLA-B/PSMD11/BAX/MAPK9/PIK3CD/CD247/PSMC2/CDK2/HLA-A/MYD88/MAP2K6/RIPK1/APAF1/MAP2K4/AKT1/SIN3A/CHUK/IRAK1/JAK1/TP53/CDK6/MAPK8/TRAF6/IKBKB/SKP2/CCNA2/NFKBIE/TRADD/TYK2/FADD/FAS/MAP3K7/TAB1/CD44/ISG15/TRAF2/TNFAIP3/PIK3R1/IKBKE	5.77008428437078
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	33/2395	54/9376	2.39239155648341	WDR48/RPA2/FANCL/ATR/RPA1/POLH/BLM/PMS2/USP1/MLH1/SLX4/BRCA2/REV1/RPA3/RAD51C/UBE2T/FANCA/TELO2/MUS81/FANCG/ERCC4/BRCA1/PALB2/RMI1/TOP3A/FANCM/FANCF/ATRIP/RMI2/FANCI/BRIP1/CENPS/FANCC	6.01012202563382
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	25/2395	36/9376	2.71862676873115	PRIM1/RNASEH2B/RPA2/RPA1/RFC1/SSBP1/PRIM2/MCM4/MCM3/RFC2/FEN1/POLA1/RFC4/RNASEH1/MCM6/PCNA/RPA3/MCM5/POLE2/DNA2/POLA2/MCM2/RFC5/POLD4/POLD1	6.05116454104459
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	46/2395	87/9376	2.06990617426151	CASP3/GADD45A/LEF1/BCL2L11/RAC2/PMAIP1/KRAS/SOS2/CTNNB1/MAPK1/CYCS/BCL2/MAP2K1/MAP2K2/SMAD4/MSH6/CASP9/RAF1/MSH3/PIK3CA/AREG/GRB2/APPL1/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/MSH2/RPS6KB1/MAPK9/PIK3CD/MLH1/GSK3B/AKT1/MTOR/TP53/RPS6KB2/TCF7/MAPK8/BBC3/RHOA/ARAF/BIRC5/PIK3R1	5.87219429419403
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	93/2395	224/9376	1.62535043244855	PRKACB/CCND3/BUB3/B2M/XPO1/CALR/KRAS/CDKN2C/CCND2/PPP3CA/ELK4/MAPK1/PPP3CC/CD3E/VDAC2/VDAC3/EP300/RAN/ANAPC5/ATM/TBPL1/HLA-F/IL2RB/CDC16/RB1/MAP2K1/MAP2K2/NFKB1/ADCY7/VDAC1/ATF2/SMAD4/RANBP1/CDKN2A/PTEN/JAK3/ATF6B/MAP3K1/ATR/PIK3CA/ANAPC7/ANAPC4/SLC25A5/POLB/ANAPC16/NRAS/GPS2/PPP3R1/HLA-B/CDC26/BAX/MAD2L1/MAPK9/TRRAP/CDC23/PIK3CD/CDC27/NFATC3/CDK2/HLA-A/ANAPC1/IL2RA/KAT2B/TBP/ANAPC10/MAP2K4/ZFP36/AKT1/CRTC3/CHUK/JAK1/TP53/KAT2A/MAPK8/IKBKB/ADCY3/ELK1/CHEK1/IL2RG/CCNA2/NFYB/KAT5/NFATC2/MAD1L1/TLN1/ETS1/PTTG1/TCF3/CCNB2/CRTC2/ADCY6/BUB1B/PIK3R1	5.5484162629963
Genetic Information Processing	Transcription	hsa03040	Spliceosome	99/2395	243/9376	1.59492770432228	SRSF5/SRSF6/DDX39B/TRA2A/BCAS2/PRPF8/HSPA8/DDX5/SRSF9/SRSF2/WBP11/CDC40/SRSF7/LSM5/PHF5A/PRPF38A/SF3B1/CWC15/LSM8/SNRPF/SMNDC1/EIF4A3/SF3B6/BUD31/MAGOH/LSM2/SNRPB2/THOC7/SRSF1/SNRNP27/CRNKL1/SRSF10/HSPA1A/HNRNPA3/ACIN1/RBM22/PPIE/SNW1/NCBP1/SRSF8/PRPF18/HNRNPK/SRSF3/CCDC12/SNRNP40/SF3B3/HNRNPU/ZMAT2/HNRNPA1/THOC3/AQR/U2SURP/PPIH/LSM6/SRSF4/SF3B5/SF3B4/DHX8/DHX15/LSM4/PRPF31/THOC1/USP39/SNRPD3/SNRPC/DDX23/NCBP2/CDC5L/PRPF3/PPIL1/SNRPA1/CWC25/RBM17/TRA2B/SYF2/SNRPD1/MAGOHB/SNRPE/PLRG1/LSM3/HNRNPC/SNRPB/SNRPA/EFTUD2/U2AF1L4/RBMXL1/CHERP/PRPF40A/RBM8A/DHX38/SNRPG/HSPA1B/BUD13/YJU2/PRPF19/THOC5/THOC6/FUS/HSPA6	5.50351531648276
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	74/2395	169/9376	1.71418265370409	PRKACB/RRAS2/TBK1/CALCOCO2/BIRC6/HIF1A/KRAS/SH3GLB1/EIF2S1/DDIT4/MAP1LC3B/RAB8A/MAPK1/ITPR1/NRBF2/DAPK2/STX17/SUPT20H/BCL2/GORASP2/ATG12/ATG16L1/MAP2K1/MAP2K2/IGBP1/ATG5/RAF1/PTEN/PPP2CA/TANK/GABARAPL2/WDR41/VMP1/ERN1/PIK3CA/NBR1/NRAS/EIF2AK3/RPS6KB1/ATG3/MAPK9/PLEKHM1/OPTN/PIK3CD/HMGB1/VAMP8/MTMR14/VPS33A/ATG4A/EPG5/VPS41/VPS11/AKT1/TAX1BP1/MTOR/RPS6KB2/ATG2B/MAPK8/TRAF6/MTMR4/ATG4D/VPS39/TSC1/MRAS/STK11/RAB33B/PRKCD/MAP3K7/RRAGB/UBB/ATG4C/PIK3R4/RAB39B/PIK3R1	5.48748260425417
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	61/2395	133/9376	1.79552011552891	KLRC1/KLRC2/GZMB/CASP3/KLRD1/SH2D1B/FCER1G/RAC2/SYK/KRAS/KLRC3/SOS2/PPP3CA/LCP2/MAPK1/BID/PPP3CC/LAT2/VAV3/NCR3/PRF1/IFNGR1/KIR2DL3/ZAP70/MAP2K1/MAP2K2/NCR1/PTK2B/RAF1/PIK3CA/GRB2/PTPN6/NRAS/PPP3R1/SOS1/HLA-B/BRAF/KIR2DL4/PIK3CD/VAV1/CD247/CD48/FASLG/HLA-A/LAT/HCST/TYROBP/TNFRSF10A/MICB/KLRK1/TNFRSF10B/NFATC2/FYN/FAS/ARAF/NCR2/CD244/KIR2DL1/ULBP2/ULBP1/PIK3R1	5.41190404420238
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	71/2395	163/9376	1.70522945297591	CASP8/CASP3/IRF7/TBK1/CASP10/KRAS/SOS2/MAPK1/BID/VDAC3/EP300/MAP2K3/CYCS/STAT4/BCL2/RB1/MAP2K1/MAP2K2/NFKB1/STAT1/STAT3/ATF2/SMAD4/IRAK4/PTK2B/CASP9/RAF1/JAK3/ATF6B/YWHAZ/MAP3K1/DDX3X/PIK3CA/GRB2/NRAS/SOS1/DDB2/BRAF/BAX/MAPK9/PIK3CD/FASLG/NFATC3/CDK2/MYD88/JAK2/MAP2K6/APAF1/MAP2K4/AKT1/CHUK/IRAK1/PCNA/JAK1/TP53/MAPK8/TRAF6/IKBKB/ELK1/CCNA2/TYK2/NFATC2/FADD/FAS/ARAF/MAP3K7/TAB1/YWHAB/BIRC5/PIK3R1/IKBKE	5.31989776624359
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	27/2395	44/9376	2.40227747200607	PARP4/MBD4/MPG/TDG/PARG/RFC1/POLB/POLG/TDP1/APEX1/HMGB1/OGG1/RFC2/FEN1/RFC4/APTX/POLG2/PCNA/POLE2/NEIL3/PARP2/LIG3/PARP3/RFC5/POLD4/MUTYH/POLD1	5.46075268873216
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	22/2395	33/9376	2.60988169798191	STX17/SEC22B/VTI1A/STX4/STX8/VAMP1/SNAP23/GOSR2/STX3/BET1/GOSR1/VAMP7/VAMP2/STX18/STX2/STX6/STX5/VAMP8/VAMP4/BET1L/BNIP1/STX1A	5.42609429514367
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	39/2395	75/9376	2.03570772442589	CCND3/CASP8/MDM2/CASP3/GADD45A/PMAIP1/SESN1/CCND2/BID/SESN2/CYCS/ATM/BCL2/CCNG1/CASP9/CDKN2A/PTEN/MDM4/ATR/DDB2/BAX/SIAH1/RCHY1/CCNG2/CDK2/PPM1D/RRM2B/COP1/APAF1/TNFRSF10A/TP53/CDK6/CCNB1/BBC3/CHEK1/TNFRSF10B/FAS/CCNB2/CDK1	5.27451586370467
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	93/2395	235/9376	1.54927019944032	DPF3/PRKACB/COX6A2/SMARCE1/NDUFC2/KRAS/SOS2/ATP5F1C/UQCRC2/NDUFB5/NDUFB3/SMARCA2/MAP2K3/SDHD/UQCRFS1/COX11/SDHA/COX14/COA5/KDM3A/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/SMARCB1/NDUFAB1/ADCY7/ATF2/NDUFAF7/SDHB/COX5A/NDUFA10/SMARCC1/KDM1A/NDUFA2/RPS6KA3/NDUFAF4/ATP5MC1/SMARCC2/NDUFA8/NDUFA6/GRB2/COX7A2L/NDUFA12/ACTL6A/NRAS/NDUFAF8/SOS1/ACSL3/COA3/NDUFB6/COA4/COX17/RPS6KB1/ATP5F1A/NDUFS3/RPS6KA1/COX19/COX7B/CYC1/PRKAG1/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/NDUFAF6/COX7C/COA1/COX10/MTOR/RPS6KB2/COA6/ATP5MF/ADCY3/TSC1/COX6A1/KDM3B/ACSL5/ATP5MG/ATP5MC2/NDUFAF5/NDUFA4/SLC25A20/COX15/COX8A/PRKAB1/ADCY6/COA7/LIPE	4.99462275944039
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	17/2395	23/9376	2.89356449124081	RPA2/MSH6/MSH3/RPA1/RFC1/SSBP1/PMS2/MSH2/MLH1/RFC2/RFC4/PCNA/RPA3/MLH3/RFC5/POLD4/POLD1	5.3253496752893
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	90/2395	227/9376	1.55213228734607	PRKACB/CASP8/MDM2/CASP3/B2M/PTGER2/TBK1/RAC2/CCR1/GNAI3/CALR/TAP1/IL10RA/KRAS/ARHGEF12/SOS2/ARHGEF1/PPP3CA/CTNNB1/MAPK1/BID/PPP3CC/ITPR1/PTGER3/PDIA3/CYCS/HLA-F/TRAF5/GNA13/RB1/MAP2K1/MAP2K2/NFKB1/ADCY7/STAT3/GNG5/ATF2/PTK2B/CASP9/RAF1/CDKN2A/GNGT2/ATF6B/PIK3CA/GRB2/BAK1/PXN/NRAS/TAP2/PPP3R1/SOS1/HLA-B/BAX/RPS6KB1/PIK3CD/FASLG/NFATC3/HLA-A/CRKL/MAP2K6/RIPK1/CALM1/CALM3/ROCK1/GSK3B/AKT1/CHUK/MTOR/JAK1/GNAI2/TP53/CDK6/RPS6KB2/CGAS/PTGER1/IKBKB/ADCY3/ELK1/TSC1/TRADD/NFATC2/FADD/FAS/RHOA/PLCB1/PLCB3/GNG10/TRAF2/ADCY6/PIK3R1	4.93229265397222
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	98/2395	253/9376	1.51641347669304	CUL1/MDM2/MALT1/PPID/ARPC5L/TBK1/ARF6/IL18/ACTR3/CASP1/CALCOCO2/RBCK1/CYTH4/PYCARD/CASP4/MAP1LC3B/MAPK1/ACTR2/UBE2N/ITPR1/CDC42/ARPC1B/CYCS/ATM/FNBP1L/CAPN2/TRAF5/BCL2/ATG12/ATG16L1/BCL10/NFKB1/TIFA/HCLS1/UBE2V2/ARPC3/UBE2V1/VDAC1/MYL12A/ATG5/UBE2D2/CYTH1/GLMN/PIK3CA/ARF1/PXN/DIAPH1/BAX/RPS6KA5/SKP1/RPS6KB1/MAPK9/MYL12B/PIK3CD/CAPN1/U2AF1L4/MYD88/CRKL/UBE2D3/ELMO2/RIPK1/ACTN4/ROCK1/GSK3B/AKT1/CHUK/ARPC4/MTOR/TP53/RPS6KB2/CGAS/MAPK8/TRAF6/ARPC5/IKBKB/CYTH2/RIPK2/TRADD/ARPC2/TLN1/RHOA/PRKCD/BTRC/PLCB1/MAP3K7/TAB1/CD44/RRAGB/PLCB3/UBB/PIK3R4/TRAF2/CAST/WASF1/ACTR3C/PIK3R1/PFN1/NOD1	4.87717757900287
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	21/2395	32/9376	2.56910229645094	CASP8/CASP3/BCL2L11/BIRC6/PMAIP1/BID/BIRC2/CYCS/BCL2/CASP9/BAK1/BAX/MAPK9/BIRC3/APAF1/HTRA2/CASP7/MAPK8/BBC3/FADD/BIRC5	5.20762148821505
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	38/2395	75/9376	1.98351009046625	CASP8/MDM2/CASP3/TOP2B/PMAIP1/MAPK1/BID/BIRC2/CYCS/ATM/BCL2/XPA/GSTM2/MSH6/CASP9/CDKN2A/ATP7A/MSH3/PIK3CA/POLH/BAK1/BAX/MSH2/PIK3CD/FASLG/MLH1/BIRC3/APAF1/AKT1/TP53/MGST2/BBC3/FADD/FAS/BRCA1/GSTP1/BIRC5/PIK3R1	5.00869062954358
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	82/2395	205/9376	1.56592901878914	GTF2B/PRKACB/CCND3/CASP8/MDM2/CASP3/RASA2/IRF7/EIF2AK2/RBL2/PMAIP1/SP100/SYK/KRAS/GTF2H2/CCND2/MAPK1/VDAC3/EP300/HDAC1/CDC42/GTF2A2/UBE3A/TBPL1/HLA-F/TRAF5/RB1/NFKB1/SNW1/HNRNPK/CDKN1B/STAT3/ATF2/RANBP1/CDKN2A/JAK3/ATF6B/YWHAZ/USP7/DDX3X/HDAC3/PIK3CA/IRF9/GRB2/RBL1/POLB/BAK1/PXN/NRAS/HLA-B/BAX/HDAC8/PIK3CD/GTF2A1/CDK2/HLA-A/KAT2B/GTF2H3/TBP/ACTN4/DNAJA3/GTF2H2C/JAK1/TP53/CDK6/KAT2A/GTF2H1/SKP2/CHEK1/HDAC10/CCNA2/HDAC5/TRADD/MAD1L1/RHOA/SCRIB/HDAC6/YWHAB/TRAF2/CDK1/PIK3R1/GTF2E1	4.79855111594704
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	66/2395	157/9376	1.64572158025611	CASP8/CASP3/COX6A2/BCL2L11/DDIT3/NDUFC2/UQCRC2/EIF2S1/NDUFB5/NDUFB3/BID/CDC42/CYCS/SDHD/ITCH/UQCRFS1/SDHA/XBP1/NFKB1/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/SDHB/COX5A/NDUFA10/NDUFA2/ERN1/MLX/PIK3CA/NDUFA8/NDUFA6/COX7A2L/NDUFA12/NDUFB6/BAX/EIF2AK3/MAPK9/PIK3CD/NDUFS3/COX7B/FASLG/CYC1/PRKAG1/UQCR10/NDUFA7/NDUFB4/RXRA/COX7A2/UQCRH/GSK3B/COX7C/CASP7/AKT1/MAPK8/IKBKB/COX6A1/SREBF1/FAS/NDUFA4/COX8A/TRAF2/PRKAB1/PIK3R1	4.77895342226391
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	43/2395	90/9376	1.87041521688703	HIF1A/KRAS/PPP3CA/MAPK1/PPP3CC/CD3E/MAP2K3/IFNGR1/ZAP70/MAP2K1/MAP2K2/NFKB1/STAT1/STAT3/RAF1/RASGRP1/PTEN/PIK3CA/CSNK2A1/PTPN6/NRAS/PPP3R1/CSNK2A2/RPS6KB1/PIK3CD/CD247/NFATC3/MYD88/LAT/JAK2/MAP2K6/CSNK2B/AKT1/CHUK/MTOR/JAK1/RPS6KB2/TRAF6/IKBKB/NFKBIE/NFATC2/BATF/PIK3R1	4.85973925304024
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	27/2395	48/9376	2.20208768267223	HMGCS1/HIBCH/ACAA2/HADH/ALDH3A2/OXCT1/ACADM/HADHB/ECHS1/DLD/PCCA/IVD/AACS/BCKDHB/ACAT2/ALDH9A1/ALDH6A1/HSD17B10/AUH/ACAD8/BCAT2/ACADSB/ACADS/MCCC1/PCCB/DBT/HIBADH	4.89037401517415
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	65/2395	156/9376	1.63117606123869	MX1/OAS2/CASP8/CASP3/OAS1/IRF7/EIF2AK2/TBK1/RSAD2/KRAS/SOS2/EIF2S1/CTNNB1/MAPK1/BID/CYCS/RB1/MAP2K1/PPP2R2A/MAP2K2/NFKB1/STAT1/PPP2R2B/STAT3/CASP9/RAF1/PPP2CA/OAS3/YWHAZ/PIK3CA/IRF9/GRB2/BAK1/NRAS/SOS1/BRAF/BAX/PIK3CD/EIF3E/MX2/FASLG/CDK2/RXRA/PPP2R2D/RIPK1/APAF1/GSK3B/AKT1/CHUK/JAK1/TP53/CDK6/TRAF6/IKBKB/IFIT1/TRADD/TYK2/FADD/FAS/ARAF/YWHAB/TRAF2/PIK3R1/IKBKE/OCLN	4.65614970823229
Genetic Information Processing	Translation	hsa03010	Ribosome	86/2395	222/9376	1.51655287855705	RPS10/RPL36A/RPS21/RPL37/RPL26/RPS19/RPL22L1/RPS15A/RSL24D1/MRPS30/MRPL42/MRPS31/RPL41/MRPL19/RPL17/MRPL3/MRPL9/MRPL44/MRPS26/MRPL18/MRPS18C/MRPL11/MRPS35/MRPL52/MRPL39/MRPL34/MRPL47/MRPS12/MRPS15/MRPS22/MRPL22/MRPS23/MRPL51/RPL14/MRPL43/MRPL14/MRPL13/MRPS10/MRPL45/MRPL1/MRPS25/MRPS11/DAP3/MRPL15/MRPL2/MRPS14/MRPL16/MRPL21/MRPS34/RPL39/MRPL49/MRPS27/MRPL36/RPL30/MRPL50/RPL3/MRPL46/MRPL30/RPS23/MRPL32/RPS7/MRPL4/RPS29/RPS18/MRPL35/FAU/RPL32/MRPL48/RPS27L/RPL34/RPL27/MRPS28/RPS25/RPS24/RPL7A/RPLP1/RPL35A/RPS3/RPS4X/RPL23A/RPL24/RPL35/MRPL38/MRPL53/RPL36AL/RPL15	4.56210626746498
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	21/2395	34/9376	2.41797863195383	POLR2B/CRCP/POLR2K/POLR3GL/POLR1D/POLR3K/POLR2H/POLR2C/POLR2F/POLR2J/POLR2D/POLR2A/POLR1E/POLR3E/POLR2M/POLR3C/POLR3A/POLR3F/POLR3G/POLR2J3/POLR1B	4.85141907524305
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	84/2395	216/9376	1.52243099048945	HSPA5/CASP8/CASP3/IRF7/TBK1/IL18/DDIT3/CASP1/HSPD1/HSPA8/ERO1A/HSPA4/CAMK2D/KRAS/EIF2S1/PYCARD/ARHGEF1/PPP3CA/MAPK1/BID/PPP3CC/RAP1A/MAP2K3/ITPR1/CDC42/VAV3/CYCS/BCL2/HSPA1A/XBP1/NFKB1/STAT3/HSP90AB1/IRAK4/CASP9/TANK/ERN1/PIK3CA/NRAS/PPP3R1/BAX/EIF2AK3/MAPK9/PIK3CD/VAV1/CAMK2G/ABCG1/FASLG/NFATC3/MYD88/RXRA/JAK2/MAP2K6/CALM1/CALM3/APAF1/MAP2K4/GSK3B/CASP7/AKT1/CHUK/IRAK1/TNFRSF10A/NCF4/CASP6/HSP90AA1/HSPA1B/TP53/MAPK8/TRAF6/IKBKB/TNFRSF10B/NFATC2/FAS/RHOA/PLCB1/MAP3K7/TAB1/PLCB3/HSPA6/TRAF2/CYP2J2/PIK3R1/IKBKE	4.54975119877747
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	25/2395	44/9376	2.22433099259822	GTF2B/MNAT1/CCNH/GTF2H2/GTF2A2/TBPL1/GTF2I/TAF15/TAF9/TAF12/TAF7/GTF2F1/GTF2F2/TAF13/GTF2A1/GTF2H3/TBP/GTF2H2C/GTF2H5/TAF4B/GTF2H1/CDK7/ERCC3/TAF5L/GTF2E1	4.76779303183434
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	36/2395	73/9376	1.93059742042497	MX1/BST2/APOBEC3G/MDFIC/CPSF6/XPO1/PDCD6IP/EP300/RAN/ELL2/APOBEC3C/SMARCB1/CCNT2/CDK9/ELL/PSIP1/NUP153/TRIM5/APOBEC3H/CCNT1/NELFCD/TNPO3/RANBP2/APOBEC3D/MLLT3/MX2/CHMP4A/NELFB/CPSF7/KAT2B/NELFA/APOBEC3F/KAT2A/BICD1/PPIA/APOBEC3B	4.67510470612938
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	70/2395	173/9376	1.58403224443989	MX1/OAS2/CCND3/CASP8/CASP3/OAS1/IRF7/EIF2AK2/TBK1/IL18/CASP1/CALCOCO2/XPO1/RSAD2/TRIM25/EIF2S1/PYCARD/KPNA2/MAPK1/BID/PABPN1/EP300/CYCS/DNAJC3/IFNGR1/ADAR/MAP2K1/MAP2K2/NFKB1/NUP98/STAT1/VDAC1/NXT1/IRAK4/CASP9/RAF1/OAS3/KPNA1/PIK3CA/IRF9/SLC25A5/NXF1/PML/BAK1/RAE1/BAX/HNRNPUL1/PIK3CD/MX2/FASLG/MYD88/JAK2/APAF1/AKT1/CHUK/TNFRSF10A/JAK1/CDK6/IKBKB/KPNA5/TRADD/TYK2/TNFRSF10B/FADD/FAS/NXT2/DNAJB1/CPSF4/PIK3R1/IKBKE	4.54124302481202
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	100/2395	268/9376	1.46075468170629	PRKACB/HSPA5/PSMA2/CASP3/PSMD12/COX6A2/DDIT3/GNAI3/CAMK2D/NDUFC2/ATP5F1C/UQCRC2/EIF2S1/UBE2J1/PSMA5/NDUFB5/NDUFB3/VDAC2/VDAC3/ITPR1/CYCS/PSMA6/SDHD/TUBA4A/UBE2G1/UQCRFS1/PSMD13/SDHA/XBP1/SLC39A10/PSMD6/PSMA1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/PSMB2/VDAC1/PSMC4/SDHB/CASP9/COX5A/NDUFA10/NDUFA2/PSMC6/ERN1/ATP5MC1/UBE2L6/NDUFA8/NDUFA6/SLC25A5/COX7A2L/TXN2/NDUFA12/PSMA3/NDUFB6/PSMD11/BAX/EIF2AK3/PSMB3/MAPK9/ATP5F1A/NDUFS3/COX7B/PSMC2/PSMD9/CAMK2G/CYC1/UBE2J2/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/CALM1/CALM3/APAF1/HTRA2/COX7C/GNAI2/TP53/MAPK8/MFN1/UBA7/SOD1/PSMB1/PARK7/COX6A1/SLC39A8/TRAP1/TUBA1B/ATP5MC2/NDUFA4/UBB/COX8A/SLC39A11	4.48234438417318
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	53/2395	122/9376	1.70070159827509	MALT1/ITK/PPP2R5A/MAP3K8/KRAS/SOS2/PPP3CA/LCP2/MAPK1/PPP3CC/CD3E/PTPRC/CDC42/VAV3/ZAP70/CARD11/MAP2K1/BCL10/PPP2R2A/MAP2K2/NFKB1/PPP2R2B/TEC1/RAF1/RASGRP1/PPP2CA/PIK3CA/GRB2/PPP2R3C/PTPN6/NRAS/PPP3R1/SOS1/MAPK9/PIK3CD/VAV1/CD247/NCK1/NFATC3/LAT/PPP2R2D/GSK3B/AKT1/CHUK/MAPK8/IKBKB/NFKBIE/NFATC2/FYN/RHOA/MAP3K7/CD8A/PIK3R1	4.56276239893723
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	34/2395	68/9376	1.95741127348643	PIM1/LEF1/PIM2/KRAS/SOS2/MAPK1/MAP2K1/MAP2K2/NFKB1/ITGAM/STAT3/RAF1/PER2/PIK3CA/GRB2/PML/NRAS/SOS1/BRAF/DUSP6/RPS6KB1/PIK3CD/AKT1/CHUK/MTOR/RPS6KB2/TCF7/IKBKB/CCNA2/ARAF/RARA/KIT/PPARD/PIK3R1	4.64092322683415
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	94/2395	250/9376	1.4719732776618	MDM2/ARFGAP3/ARPC5L/ARF6/STAM/ACTR3/ARAP2/VPS26A/HSPA8/SMAP2/RAB11FIP4/SMURF2/CHMP5/PSD4/SH3GLB1/SNX1/CYTH4/EPS15/RAB8A/CAPZA1/PDCD6IP/ACTR2/CDC42/SNX3/CAPZA2/ARPC1B/VPS36/IGF2R/ITCH/HLA-F/HSPA1A/RAB5A/IL2RB/ARFGEF1/AGAP2/WIPF1/SMAP1/ARF4/ARRB2/ARPC3/RAB22A/SNX4/RAB10/SNX5/GRK2/ACAP2/EPS15L1/CYTH1/ARFGAP2/ARF5/VTA1/STAMBP/ARF1/VPS29/ACAP1/RAB11FIP1/PML/HLA-B/RUFY1/SNX6/ZFYVE27/STAM2/CHMP4A/HLA-A/RAB4A/SNF8/IL2RA/ARFGEF2/BIN1/GIT2/WASHC1/ARPC4/PIP5K1A/WASHC2A/VPS25/WASHC5/HSPA1B/VPS45/RUFY2/ARAP1/TRAF6/ARPC5/CHMP7/CYTH2/IL2RG/RNF41/WASHC2C/ARPC2/RHOA/LDLRAP1/SMURF1/HSPA6/ACTR3C/WIPF3	4.43023496618546
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	39/2395	83/9376	1.83949493171014	OGT/MTF2/JARID2/RBBP4/CBX4/EP300/TFDP1/HDAC1/PCGF5/SUZ12/AEBP2/PHC3/LCOR/MBD5/RBBP7/EZH2/RNF2/USP7/ASXL2/UBE2D2/KDM2A/EED/YY1/PHF1/SKP1/UBE2D3/FBRS/RYBP/CSNK2B/ASXL1/FOXK2/PCGF6/FOXK1/L3MBTL2/USP45/CBX8/TEX10/KDM2B/YY2	4.49944279025425
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	101/2395	275/9376	1.43780755361549	PRKACB/HSPA5/STIP1/PSMA2/CASP3/PSMD12/COX6A2/RAC2/NCAM1/DDIT3/HSPA8/NDUFC2/ATP5F1C/UQCRC2/EIF2S1/PSMA5/PPP3CA/NDUFB5/NDUFB3/MAPK1/PPP3CC/VDAC2/VDAC3/ITPR1/CYCS/PSMA6/SDHD/TUBA4A/UQCRFS1/HSPA1A/PSMD13/SDHA/PSMD6/PSMA1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/PSMB2/VDAC1/ATF2/PSMC4/SDHB/CASP9/COX5A/NDUFA10/ATF6B/NDUFA2/PSMC6/ATP5MC1/PIK3CA/NDUFA8/NDUFA6/SLC25A5/COX7A2L/CSNK2A1/NDUFA12/PSMA3/PPP3R1/CSNK2A2/NDUFB6/PSMD11/BAX/EIF2AK3/PSMB3/MAPK9/ATP5F1A/PIK3CD/NDUFS3/COX7B/PSMC2/PSMD9/CYC1/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/CSNK2B/APAF1/GSK3B/COX7C/NCF4/HSPA1B/MAPK8/SOD1/NOTCH1/PSMB1/COX6A1/TUBA1B/FYN/PRKCD/ATP5MC2/NDUFA4/COX8A/HSPA6/PIK3R1	4.31603162361583
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	162/2395	480/9376	1.32125260960334	HSPA5/CASP8/PSMA2/CASP3/PSMD12/COX6A2/PPID/TBK1/DDIT3/CAMK2D/NDUFC2/KRAS/ATP2A2/ATP5F1C/UQCRC2/EIF2S1/UBE2J1/MAP1LC3B/PSMA5/RAB8A/PPP3CA/CTNNB1/NDUFB5/NDUFB3/MAPK1/BID/PPP3CC/CSNK1A1/VDAC2/VDAC3/MAP2K3/ITPR1/NRBF2/CYCS/PSMA6/SDHD/TUBA4A/UBE2G1/CAPN2/IFT57/SPG11/UQCRFS1/BCL2/RAB5A/PSMD13/ATXN2L/SDHA/XBP1/DERL1/HTT/PSMD6/MAP2K1/MAP2K2/PSMA1/NFKB1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/ACTR10/NDUFAB1/PSMB2/VDAC1/CSF1/PSMC4/SDHB/CASP9/RAF1/COX5A/NDUFA10/TANK/NDUFA2/PSMC6/WDR41/ERN1/TARDBP/ATP5MC1/UBE2L6/NDUFA8/NDUFA6/SLC25A5/COX7A2L/BAK1/CSNK2A1/NDUFA12/CAT/PSMA3/NRAS/PPP3R1/CSNK2A2/NDUFB6/PSMD11/BRAF/BAX/EIF2AK3/PSMB3/MAPK9/ATP5F1A/OPTN/NDUFS3/ATXN1L/HSD17B10/CAPN1/COX7B/PSMC2/PSMD9/CAMK2G/FASLG/CYC1/UBE2J2/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/MAP2K6/CSNK2B/CALM1/CALM3/APAF1/HTRA2/GSK3B/COX7C/CASP7/FRAT2/MTOR/DCTN6/CDK5/ATG2B/MAPK8/MFN1/UBA7/SOD1/ATXN3/PSMB1/PARK7/COX6A1/TRAP1/DNAH14/TUBA1B/FADD/FAS/ARAF/PLCB1/ATP5MC2/NDUFA4/PSEN2/PLCB3/FUS/UBB/PIK3R4/RAB39B/DNAL4/COX8A/TRAF2/WNT11/STX1A/MAP3K10/FRAT1	4.23203717396485
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	23/2395	41/9376	2.19611996537502	ATM/UIMC1/RPA2/BARD1/RPA1/SSBP1/TOPBP1/BLM/RBBP8/BRCA2/RAD51D/RPA3/RAD51C/RAD51B/MUS81/RAD50/BRCA1/PALB2/POLD4/TOP3A/BRIP1/RAD54B/POLD1	4.49561472335943
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	50/2395	117/9376	1.67300108844994	DPF3/SMARCE1/RBBP4/PHF6/EPC1/SMARCA2/SS18/HDAC1/MEAF6/ARID2/DPF2/PHF10/ACTR6/BRD7/SMARCB1/UCHL5/RBBP7/PBRM1/CHD3/GATAD2A/SMARCA5/SMARCC1/GATAD2B/SMARCC2/BCL7C/ACTL6A/EPC2/MBD2/YY1/BCL7B/RUVBL1/TRRAP/MTA2/ING3/MRGBP/MORF4L2/INO80D/VPS72/CDK2AP2/YEATS4/BRD8/ACTR8/MCRS1/ACTR5/KAT5/MTA1/DMAP1/SS18L1/INO80B/YY2	4.29048347404771
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	110/2395	308/9376	1.39815090963316	CASP8/PSMA2/CASP3/PSMD12/COX6A2/POLR2B/NDUFC2/POLR2K/ATP5F1C/UQCRC2/TFAM/PSMA5/NDUFB5/NDUFB3/VDAC2/VDAC3/EP300/ITPR1/NRBF2/HDAC1/CYCS/PSMA6/SDHD/TUBA4A/TBPL1/IFT57/UQCRFS1/PSMD13/SDHA/HTT/PSMD6/PSMA1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/ACTR10/NDUFAB1/POLR2H/PSMB2/VDAC1/PSMC4/SDHB/CASP9/COX5A/NDUFA10/NDUFA2/POLR2C/PSMC6/ERN1/POLR2F/ATP5MC1/NDUFA8/NDUFA6/SLC25A5/COX7A2L/POLR2J/NDUFA12/PSMA3/NDUFB6/POLR2D/PSMD11/BAX/POLR2A/PSMB3/MAPK9/ATP5F1A/NDUFS3/COX7B/REST/PSMC2/PSMD9/CYC1/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/TBP/RCOR1/APAF1/COX7C/SIN3A/MTOR/DCTN6/TP53/ATG2B/MAPK8/SOD1/TAF4B/PSMB1/BBC3/COX6A1/DNAH14/TUBA1B/PLCB1/ATP5MC2/NDUFA4/PLCB3/PIK3R4/DNAL4/COX8A/TRAF2/NRF1/POLR2J3/STX1A/MAP3K10	4.16147119500319
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	47/2395	110/9376	1.67269690643386	PRKACB/GNAI3/KRAS/MAPK1/ANAPC5/BUB1/CDC16/MAP2K1/FZR1/ADCY7/HSP90AB1/RAF1/RPS6KA3/PIK3CA/ANAPC7/ANAPC4/MAD2L2/ANAPC16/BRAF/CDC26/MAD2L1/MAPK9/CDC23/PIK3CD/RPS6KA1/CDC27/CDK2/ANAPC1/ANAPC10/AKT1/HSP90AA1/GNAI2/CCNB1/MAPK8/ADCY3/CPEB2/CCNA2/MAD1L1/ARAF/SPDYA/AURKA/CCNB2/ADCY6/PLK1/CDK1/PIK3R1/CDC25C	4.15670499359137
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	56/2395	138/9376	1.58862364224986	COX6A2/NDUFC2/ATP5F1C/UQCRC2/NDUFB5/NDUFB3/CYCS/SDHD/UQCRFS1/COX11/SDHA/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/ATP6V1G1/SDHB/TCIRG1/COX5A/NDUFA10/ATP6V1D/NDUFA2/ATP6V1H/ATP5MC1/NDUFA8/NDUFA6/COX7A2L/NDUFA12/NDUFB6/COX17/ATP5F1A/NDUFS3/ATP6V0E2/COX7B/PPA1/CYC1/UQCR10/PPA2/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/COX7C/COX10/ATP5MF/COX6A1/ATP5MG/ATP5MC2/NDUFA4/COX15/COX8A/ATP6V1E2	4.08007215933736
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	50/2395	120/9376	1.63117606123869	CAMK2D/KRAS/SOS2/MAPK1/RAP1A/CDC42/BCL2/MAP2K1/MAP2K2/NFKB1/SORT1/IRAK4/RAF1/KIDINS220/RPS6KA3/MAP3K1/PIK3CA/GRB2/MATK/NRAS/SOS1/BRAF/BAX/RPS6KA5/MAPK9/GAB1/PIK3CD/RPS6KA1/CAMK2G/FASLG/CRKL/CAMK4/CALM1/CALM3/GSK3B/AKT1/IRAK1/TP53/MAPK8/TRAF6/IKBKB/ARHGDIB/RIPK2/NFKBIE/SH2B1/RHOA/PRKCD/PSEN2/MAP2K5/PIK3R1	4.07576416940767
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	29/2395	59/9376	1.92423481122395	NT5C3A/DCK/CTPS1/NT5C2/NME3/CMPK2/UPP1/DCTPP1/NME7/DPYD/ENTPD4/NME1/NUDT2/CDADC1/UMPS/DCTD/RRM2B/DTYMK/NME6/AK9/TYMS/RRM1/ASMTL/UCK1/UCK2/CAD/CTPS2/DHODH/TK1	4.171092857696
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	74/2395	196/9376	1.47804524732649	CASP8/CASP3/PIK3R6/LEF1/IRF7/EIF2AK2/TBK1/CCR1/SYK/HIF1A/PIK3CG/KRAS/CLEC2B/MAP1LC3B/PPP3CA/CTNNB1/MAPK1/BID/PPP3CC/EP300/ITPR1/CYCS/HLA-F/IFNGR1/RB1/MAP2K1/MAP2K2/NFKB1/STAT1/STAT3/GNG5/CASP9/RAF1/GNGT2/PIK3CA/IRF9/BAK1/NRAS/PPP3R1/HLA-B/BAX/ATG3/MAPK9/PIK3CD/NFATC3/HLA-A/JAK2/MAP2K6/CALM1/CALM3/MAP2K4/GSK3B/ZFP36/AKT1/CHUK/MTOR/JAK1/MICB/TP53/CDK6/TCF7/MAPK8/IKBKB/PREX1/TRADD/TYK2/NFATC2/FADD/FAS/UBB/GNG10/TRAF2/PIK3R1/IKBKE	3.96146002648652
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	75/2395	200/9376	1.46805845511482	CASP8/CASP3/ARPC5L/ARF6/MYO1E/IL18/ACTR3/CASP1/ARHGEF12/CYTH4/PYCARD/ARHGEF1/CASP4/MAPK1/ACTR2/CDC42/ARPC1B/CYCS/TUBA4A/GNA13/SEC24D/NFKB1/WIPF1/HCLS1/ARPC3/IRAK4/CASP9/CYTH1/NCKAP1L/ARF1/TMED10/BAK1/ABI1/PTPN6/CYFIP2/BAX/MAPK9/NCK1/FASLG/BRK1/MYD88/RIPK1/ROCK1/CASP7/SEC24A/CHUK/ARPC4/IRAK1/TNFRSF10A/SEC24B/MYO1D/MAPK8/NCL/TRAF6/ARPC5/IKBKB/CYTH2/TRADD/ARPC2/TNFRSF10B/TUBA1B/FYN/FADD/FAS/RHOA/MAP3K7/TAB1/RPS3/LPAR2/TMBIM6/TRAF2/WASF1/ACTR3C/WIPF3/OCLN	3.91893417011452
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	35/2395	77/9376	1.77946479407857	ARHGEF6/GADD45A/RAC2/KRAS/MAPK1/CDC42/RB1/MAP2K1/NFKB1/STAT1/STAT3/SMAD4/CASP9/RAF1/CDKN2A/PIK3CA/BAK1/DDB2/BRAF/BAX/RPS6KB1/MAPK9/PIK3CD/AKT1/CHUK/BRCA2/MTOR/JAK1/TP53/CDK6/RPS6KB2/MAPK8/IKBKB/ARAF/PIK3R1	4.02256732075016
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	55/2395	138/9376	1.56025536292397	CUL1/PRKACB/PPP2R5A/CAMK2D/PPP3CA/MAPK1/PPP3CC/PPP1CB/ITPR1/PPP1CC/ANAPC5/BUB1/CDC16/MAP2K1/ADCY7/PPP2CA/YWHAZ/RPS6KA3/ANAPC7/ANAPC4/MAD2L2/ANAPC16/PPP3R1/SMC3/CDC26/SLK/SKP1/MAD2L1/CDC23/RPS6KA1/CDC27/CAMK2G/CDK2/ANAPC1/STAG3/CALM1/CALM3/ANAPC10/CCNB1/REC8/ADCY3/CPEB2/MAD1L1/BTRC/SPDYA/AURKA/PTTG1/FBXO5/YWHAB/CCNB2/ADCY6/SGO1/PLK1/CDK1/CDC25C	3.88343611148262
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	35/2395	78/9376	1.75665114287244	SACM1L/PIP4K2A/IP6K2/PIK3CG/INPP4A/PPIP5K2/INPP5D/PTEN/PIKFYVE/IMPA1/PIK3CA/MTM1/IP6K1/PIK3CD/MTMR6/ALDH6A1/MTMR14/INPP5A/INPP5B/INPP1/PLCH2/PIP4K2C/MTMR1/PIP5K1A/INPP5F/MTMR4/MTMR2/PLCB1/SYNJ1/PLCB3/PI4K2B/PPIP5K1/MINPP1/ISYNA1/IPPK	3.93031900036469
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	70/2395	187/9376	1.46544159512353	OAS2/CASP8/OAS1/PSTPIP1/IRF7/TBK1/IL18/CASP1/CARD16/RBCK1/SUGT1/PYCARD/CASP4/MAP1LC3B/MAPK1/VDAC2/VDAC3/ITPR1/DNM1L/BIRC2/TRAF5/BCL2/ATG12/IFI16/ATG16L1/NFKB1/STAT1/TRPM7/VDAC1/HSP90AB1/IRAK4/ATG5/TANK/PKN2/OAS3/GABARAPL2/CARD8/TP53BP1/IRF9/TXN2/TRPV2/GBP4/MAPK9/MYD88/RIPK1/BIRC3/GBP3/NOD2/CHUK/JAK1/TXNIP/HSP90AA1/MAPK8/MFN1/TRAF6/IKBKB/RIPK2/TYK2/FADD/RHOA/PRKCD/PLCB1/MAP3K7/TAB1/PLCB3/NLRP1/TRAF2/TNFAIP3/NOD1/IKBKE	3.76557626481213
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	130/2395	388/9376	1.31166734821256	CASP8/PSMA2/CASP3/PSMD12/COX6A2/PPID/EIF2AK2/DDIT3/NDUFC2/KRAS/ATP2A2/ATP5F1C/UQCRC2/EIF2S1/PSMA5/PPP3CA/CTNNB1/NDUFB5/NDUFB3/MAPK1/BID/PPP3CC/CSNK1A1/VDAC2/VDAC3/ITPR1/NRBF2/CYCS/PSMA6/SDHD/TUBA4A/CAPN2/UQCRFS1/PSMD13/SDHA/XBP1/SLC39A10/PSMD6/MAP2K1/MAP2K2/PSMA1/NFKB1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/PSMB2/VDAC1/CSF1/ADAM10/PSMC4/SDHB/CASP9/RAF1/COX5A/NAE1/NDUFA10/NDUFA2/PSMC6/ERN1/ATP5MC1/PIK3CA/NDUFA8/NDUFA6/SLC25A5/COX7A2L/CSNK2A1/NDUFA12/PSMA3/NRAS/PPP3R1/CSNK2A2/NDUFB6/PSMD11/BRAF/EIF2AK3/PSMB3/MAPK9/ATP5F1A/PIK3CD/NDUFS3/HSD17B10/CAPN1/COX7B/PSMC2/PSMD9/CYC1/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/CSNK2B/CALM1/CALM3/APAF1/GSK3B/COX7C/CASP7/AKT1/FRAT2/CHUK/MTOR/CDK5/ATG2B/MAPK8/IKBKB/PSMB1/COX6A1/SLC39A8/TUBA1B/FADD/FAS/ARAF/PLCB1/ATP5MC2/NDUFA4/PSEN2/PLCB3/PIK3R4/COX8A/TRAF2/SLC39A11/WNT11/PIK3R1/FRAT1	3.67244427708097
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	28/2395	59/9376	1.85788188669898	GADD45A/LEF1/KRAS/SOS2/CTNNB1/MAPK1/MAP2K1/MAP2K2/CASP9/RAF1/PTEN/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/PIK3CD/MLH1/GSK3B/AKT1/TP53/TCF7/ELK1/ARAF/PIK3R1	3.87164059057483
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	50/2395	125/9376	1.56592901878914	SPTSSB/FCER1G/RAC2/GNAI3/PPP2R5A/KRAS/ORMDL1/DEGS1/MAPK1/ORMDL3/BID/BCL2/GNA13/MAP2K1/PPP2R2A/MAP2K2/NFKB1/PPP2R2B/RAF1/PTEN/CERS6/PPP2CA/SPTLC1/PIK3CA/SGMS1/CERS2/PPP2R3C/NRAS/BAX/NSMAF/MAPK9/PIK3CD/SGMS2/CERS5/S1PR4/PPP2R2D/ROCK1/AKT1/GNAI2/TP53/MAPK8/ABCC1/TRADD/FYN/RHOA/PLCB1/SPHK2/PLCB3/TRAF2/PIK3R1	3.73080205794167
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	43/2395	105/9376	1.60321304304603	RRAS2/TBK1/CALCOCO2/OPA1/SMURF2/HIF1A/KRAS/USP15/EIF2S1/MAP1LC3B/RAB5A/ARIH1/GABARAPL2/SAMM50/MTX2/HUWE1/CSNK2A1/NBR1/NRAS/CSNK2A2/SIAH1/EIF2AK3/MAPK9/BCL2L13/OPTN/PGAM5/CCZ1B/TOMM70/CSNK2B/TAX1BP1/CCZ1/RHOT1/TP53/MAPK8/TOMM7/MFN1/MTX3/MRAS/FUNDC1/UBB/SMURF1/TRAF2/TFEB	3.64067289634336
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	39/2395	93/9376	1.64169977776281	LEF1/RAC2/SMURF2/ACP1/CTNNB1/MAPK1/RAP1A/EP300/CDC42/YES1/PTPRJ/FER/MYL12A/SMAD4/PDCD10/WAS/CSNK2A1/PTPN6/CSNK2A2/MYL12B/SSX2IP/CSNK2B/ACTN4/CCM2/ROCK1/NECTIN1/LMO7/TCF7/NECTIN3/HEG1/IQGAP1/FYN/SNAI1/RHOA/MAP3K7/FARP2/SMURF1/WASF1/RADIL	3.64257720941428
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	53/2395	138/9376	1.50351880427219	SOCS1/PRKACB/PPP1R3B/PRKAR1A/SOCS4/KRAS/MKNK2/EIF4E/SOS2/MAPK1/PPP1CB/PPP1CC/MAP2K1/MAP2K2/FLOT1/MKNK1/SOCS2/RAF1/EIF4E2/PRKAR2B/PIK3CA/GRB2/PHKG2/NRAS/SOS1/BRAF/RPS6KB1/MAPK9/PIK3CD/INPP5A/CRKL/PRKAG1/CALM1/CALM3/GSK3B/AKT1/MTOR/RPS6KB2/MAPK8/IKBKB/PYGM/ACACA/PPP1R3E/ELK1/TSC1/SREBF1/PRKAR1B/ARAF/PHKA2/PPP1R3F/PRKAB1/PIK3R1/LIPE	3.49016401577316
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	40/2395	98/9376	1.59788675386647	SACM1L/PIP4K2A/IP6K2/INPP4A/DGKZ/ITPR1/PPIP5K2/INPP5D/PTEN/PIKFYVE/IMPA1/DGKE/PIK3CA/DGKD/MTM1/IP6K1/PIK3CD/MTMR6/MTMR14/INPP5A/INPP5B/INPP1/PIP4K2C/CDS2/CALM1/CALM3/MTMR1/PIP5K1A/DGKH/INPP5F/MTMR4/MTMR2/PLCB1/SYNJ1/PLCB3/PI4K2B/PPIP5K1/PIP4P1/IPPK/PIK3R1	3.48485220098444
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/2395	133/9376	1.50117255560613	MDM2/GADD45A/BCL2L11/RBL2/KRAS/SOS2/CCND2/MAPK1/CDKN2D/EP300/PLK2/ATM/ATG12/AGAP2/SIRT1/MAP2K1/MAP2K2/CDKN1B/STAT3/SMAD4/RAF1/PTEN/GABARAPL2/USP7/PIK3CA/GRB2/CAT/NRAS/SOS1/BRAF/MAPK9/PIK3CD/CCNG2/S1PR4/FASLG/CDK2/PRKAG1/AKT1/CHUK/CCNB1/MAPK8/STK4/IKBKB/SKP2/STK11/ARAF/CCNB2/PRKAB1/PLK4/PLK1/PIK3R1	3.40946473581601
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	17/2395	32/9376	2.07974947807933	HIBCH/SUCLA2/SUCLG2/ECHDC1/LDHB/ECHS1/DLD/SUCLG1/PCCA/BCKDHB/ALDH6A1/ACACA/ACADS/MLYCD/PCCB/DBT/LDHA	3.5835309123268
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	16/2395	30/9376	2.08790535838553	SUCLA2/SUCLG2/SDHD/SDHA/MDH1/PDHA1/IDH2/SDHB/IDH3A/DLD/SUCLG1/DLST/PDHB/FH/DLAT/ACLY	3.49557345681596
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	79/2395	227/9376	1.36242723000377	PRKD3/COX6A2/HIF1A/NDUFC2/KRAS/SOS2/ATP5F1C/UQCRC2/ACP1/NDUFB5/NDUFB3/MAPK1/VDAC2/VDAC3/SDHD/UQCRFS1/SDHA/PTPRJ/MAP2K1/MAP2K2/GSTM2/NFKB1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/VDAC1/SDHB/RAF1/COX5A/NDUFA10/PTEN/NDUFA2/ATP5MC1/PIK3CA/NDUFA8/NDUFA6/GRB2/SLC25A5/COX7A2L/NDUFA12/CAT/NRAS/SOS1/NDUFB6/BRAF/MAPK9/ATP5F1A/PIK3CD/NDUFS3/COX7B/CYC1/UQCR10/NDUFA7/ATP5PO/NDUFB4/ARNT/COX7A2/UQCRH/MAP2K4/COX7C/AKT1/CHUK/MAPK8/SOD1/MGST2/IKBKB/COX6A1/PRKCD/ARAF/ATP5MC2/NDUFA4/COX8A/SLC26A6/PIK3R1/SLC26A2	3.23762475971028
Human Diseases	Cancer: specific types	hsa05214	Glioma	32/2395	76/9376	1.64834633556752	MDM2/GADD45A/CAMK2D/KRAS/CAMK1/SOS2/MAPK1/RB1/MAP2K1/MAP2K2/RAF1/CDKN2A/PTEN/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/PIK3CD/CAMK2G/CAMK4/CALM1/CALM3/AKT1/MTOR/TP53/CDK6/ARAF/PIK3R1	3.32393069863658
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/2395	73/9376	1.66245888981039	GADD45A/KRAS/RASSF1/SOS2/MAPK1/RASSF5/RB1/MAP2K1/MAP2K2/STAT3/CASP9/RAF1/CDKN2A/JAK3/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/PIK3CD/RXRA/AKT1/TP53/CDK6/STK4/ARAF/FHIT/PIK3R1	3.32803917719382
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	25/2395	56/9376	1.74768863704146	CASP8/CASP3/IL18/CASP1/HSPD1/HSPA8/PYCARD/HBS1L/SEC22B/CYCS/HSPA1A/CLK4/SAR1B/NFKB1/ITGAM/SAR1A/CASP9/ARF1/BCL2L13/HSF1/MYD88/APAF1/CASP7/HSPA1B/HSPA6	3.28689942885233
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	34/2395	83/9376	1.60366224815756	ECI2/FAR1/SLC27A2/SCP2/AGPS/PEX2/IDH2/HSD17B4/GSTK1/ABCD3/PEX6/CAT/ECH1/ACSL3/NUDT19/CROT/PMVK/PECR/PXMP2/PEX3/PEX13/ACOT8/PHYH/DHRS4/SOD1/PXMP4/HACL1/ACSL5/MLYCD/PEX14/ABCD2/GNPAT/FAR2/MVK	3.23544984921841
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	39/2395	99/9376	1.54220282153476	PRKACB/MDM2/KRAS/CDKN2C/SOS2/MAPK1/JAG1/BCL2/RB1/MAP2K1/MAP2K2/ADCY7/CDKN1B/RAF1/CDKN2A/NOTCH2/PIK3CA/GRB2/NRAS/SOS1/BRAF/BAX/RPS6KB1/MAPK9/NCOR1/NCOA3/PIK3CD/JAG2/AKT1/MTOR/DLL1/TP53/RPS6KB2/MAPK8/NOTCH1/ADCY3/ARAF/ADCY6/PIK3R1	3.17654615743794
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	16/2395	31/9376	2.02055357263115	HSPA5/SPCS3/SRP19/SRP54/SRP9/IMMP1L/SEC11A/SRPRB/SRPRA/SRP72/SEC61B/SPCS1/UBL4A/SEC61A2/SEC61G/IMMP2L	3.3335469757533
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	56/2395	154/9376	1.42357183526286	GCH1/MAT2A/MTHFD2/ALAS1/ALDH3A2/PANK2/GUSB/CTPS1/MTHFD1/MTHFD2L/DLD/NME3/CMPK2/RFK/PANK3/UGP2/PPCS/PPCDC/GGCX/NME7/ADSL/RDH11/NME1/UMPS/SHMT2/MAT2B/COQ5/LIAS/PMM2/COX10/PHOSPHO2/AK6/GSS/DHFR/MMAB/PPOX/MOCS2/SHMT1/NME6/AK9/GMPPA/BCAT2/AK4/FECH/CPOX/GGH/COX15/NFS1/PSAT1/TPK1/CAD/CTPS2/GPHN/DHODH/LIPT1/AFMID	3.10423402062743
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	30/2395	72/9376	1.63117606123869	CASP8/IRF7/TBK1/CASP10/CYLD/RNF125/TRIM25/SIKE1/AZI2/ATG12/ADAR/NFKB1/ATG5/TANK/MAP3K1/DDX3X/MAPK9/OTUD5/RIPK1/CHUK/MAPK8/TRAF6/IKBKB/TRADD/FADD/MAP3K7/TKFC/ISG15/TRAF2/IKBKE	3.1489190361024
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	71/2395	205/9376	1.35586536992719	COX6A2/RAC2/MPC2/CAMK2D/NDUFC2/ATP2A2/ATP5F1C/UQCRC2/NDUFB5/NDUFB3/PPP1CB/VDAC2/VDAC3/PPP1CC/GSR/SDHD/UQCRFS1/SDHA/PDHA1/NFKB1/ATP5MC3/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/VDAC1/SDHB/COX5A/NDUFA10/PTEN/NDUFA2/ATP5MC1/PIK3CA/NDUFA8/NDUFA6/SLC25A5/COX7A2L/NDUFA12/NDUFB6/MAPK9/PDHB/ATP5F1A/PIK3CD/NDUFS3/COX7B/MPC1/CAMK2G/CYC1/UQCR10/NDUFA7/ATP5PO/NDUFB4/COX7A2/UQCRH/GSK3B/COX7C/AKT1/NCF4/MTOR/MAPK8/COX6A1/PRKCD/PLCB1/ATP5MC2/NDUFA4/PLCB3/PDK3/COX8A/PIK3R1	3.01740697383684
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	21/2395	46/9376	1.78720159753109	PSMA2/PSMD12/PSMB8/PSMA5/PSMB9/PSMA6/PSMD13/PSMD6/PSMA1/PSMB2/PSMC4/PSMC6/PSME4/PSMA3/PSME2/PSMD11/PSMB3/PSMC2/PSMD9/PSMB10/PSMB1	3.13475525299841
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2395	98/9376	1.51799241617315	ARPC5L/ARF6/RAC2/ACTR3/SYK/MAPK1/ACTR2/PTPRC/VASP/CDC42/VAV3/ARPC1B/INPP5D/MAP2K1/ARPC3/RAF1/LIMK1/WAS/PIK3CA/RPS6KB1/PIK3CD/VAV1/CRKL/LAT/BIN1/AKT1/ARPC4/PIP5K1A/RPS6KB2/PLA2G6/ARPC5/ARPC2/PRKCD/CFL1/SPHK2/WASF1/ACTR3C/PIK3R1	3.01917879919679
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	40/2395	105/9376	1.49136097027538	CASP8/MDM2/RRAS2/MALT1/FCER1G/CYLD/CASP1/SYK/KRAS/ARHGEF12/PYCARD/PPP3CA/MAPK1/PPP3CC/ITPR1/BCL10/NFKB1/STAT1/RAF1/PIK3CA/IRF9/NRAS/PPP3R1/MAPK9/IRF1/PIK3CD/KSR1/NFATC3/CALM1/CALM3/AKT1/CHUK/MAPK8/IKBKB/MRAS/NFATC2/RHOA/PRKCD/PIK3R1/IKBKE	2.96559331305114
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	31/2395	77/9376	1.57609738904102	MDM2/GADD45A/KRAS/SOS2/MAPK1/HDAC1/RB1/MAP2K1/MAP2K2/NFKB1/CDKN1B/SMAD4/RAF1/CDKN2A/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/PIK3CD/CRKL/AKT1/CHUK/TP53/CDK6/IKBKB/ARAF/PIK3R1	2.97305349559162
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	29/2395	71/9376	1.59901202622835	SOCS1/SOCS4/KRAS/SOS2/CCND2/MAPK1/CISH/MAP2K1/MAP2K2/NFKB1/STAT1/SOCS2/STAT3/RAF1/PIK3CA/GRB2/NRAS/SOS1/MAPK9/IRF1/PIK3CD/JAK2/GSK3B/AKT1/MAPK8/TNFSF11/SOCS6/SOCS7/PIK3R1	2.96746841690253
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	56/2395	158/9376	1.38753204196506	KRAS/CAB39/EIF4E/SOS2/DDIT4/MAPK1/SESN2/RICTOR/FNIP1/MAP2K1/MAP2K2/LPIN1/LAMTOR3/SLC3A2/SLC7A5/ATP6V1G1/RAF1/EIF4E2/PTEN/ATP6V1D/ATP6V1H/RPS6KA3/PIK3CA/GRB2/NRAS/WDR59/SOS1/BRAF/RPS6KB1/NPRL2/PIK3CD/RPS6KA1/EIF4B/SEC13/TTI1/GSK3B/AKT1/CHUK/MTOR/STRADB/RPS6KB2/IKBKB/TELO2/TBC1D7/SKP2/TSC1/STK11/DEPDC5/RHOA/MIOS/RRAGB/FLCN/STRADA/WNT11/ATP6V1E2/PIK3R1	2.87738109826006
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	36/2395	93/9376	1.51541517947337	PPP3CA/MAML3/MAPK1/PPP3CC/CD3E/JAG1/STAT4/GATA3/IFNGR1/IL2RB/ZAP70/NFKB1/STAT1/RUNX3/JAK3/NOTCH2/PPP3R1/MAPK9/CD247/TBX21/NFATC3/JAG2/IL2RA/LAT/JAK2/IL4R/CHUK/DLL1/JAK1/MAPK8/IKBKB/NOTCH1/IL2RG/NFKBIE/TYK2/NFATC2	2.92572890188814
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	59/2395	168/9376	1.37484839447261	CASP8/PPID/EIF2AK2/CYLD/CASP1/RBCK1/CAMK2D/ZBP1/CHMP5/PYCARD/BID/VDAC2/VDAC3/DNM1L/BIRC2/STAT4/CAPN2/TRAF5/BCL2/IFNGR1/STAT1/STAT3/TRPM7/VDAC1/GLUD1/HSP90AB1/JAK3/IRF9/SLC25A5/MLKL/BAX/MAPK9/PGAM5/CAPN1/HMGB1/CAMK2G/SPATA2L/FASLG/CHMP4A/AIFM1/JAK2/RIPK1/BIRC3/TNFRSF10A/JAK1/HSP90AA1/MAPK8/CHMP7/PYGM/SPATA2/TRADD/TYK2/TNFRSF10B/FADD/FAS/USP21/PPIA/TRAF2/TNFAIP3	2.871489408128
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/2395	119/9376	1.4474974123261	CASP8/CASP3/CASP10/CYLD/MAP3K8/MAPK1/MAP2K3/JAG1/DNM1L/BIRC2/ITCH/TRAF5/MAP2K1/NFKB1/ATF2/CSF1/ATF6B/PIK3CA/MLKL/BAG4/RPS6KA5/MAPK9/IRF1/PIK3CD/PGAM5/MAP2K6/RIPK1/BIRC3/MAP2K4/CASP7/AKT1/NOD2/CHUK/FRMD8/MAPK8/IKBKB/TRADD/FADD/FAS/MAP3K7/TAB1/TRAF2/TNFAIP3/PIK3R1	2.87745443506026
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/2395	69/9376	1.58862364224986	FCER1G/RAC2/SYK/KRAS/SOS2/LCP2/MAPK1/MAP2K3/VAV3/INPP5D/MAP2K1/MAP2K2/RAF1/PIK3CA/GRB2/NRAS/SOS1/MAPK9/PIK3CD/VAV1/ALOX5AP/LAT/MAP2K6/MAP2K4/AKT1/MAPK8/FYN/PIK3R1	2.87433225313648
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	35/2395	91/9376	1.50570097960495	PIK3AP1/MALT1/RAC2/SYK/KRAS/SOS2/PPP3CA/MAPK1/PPP3CC/VAV3/INPP5D/CARD11/MAP2K1/BCL10/MAP2K2/NFKB1/RAF1/PIK3CA/GRB2/PTPN6/NRAS/PPP3R1/SOS1/DAPP1/PIK3CD/VAV1/BANK1/NFATC3/GSK3B/AKT1/CHUK/IKBKB/NFKBIE/NFATC2/PIK3R1	2.83924660471498
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	33/2395	85/9376	1.5198722829424	HPRT1/GMPS/NT5C3A/NTPCR/DCK/CTPS1/DGUOK/NT5C2/NME3/CMPK2/UPP1/DCTPP1/PNP/NME7/ENTPD4/ADSL/NME1/DCTD/RRM2B/AK6/DTYMK/AMPD2/NME6/AK9/IMPDH1/AK4/TYMS/RRM1/ASMTL/UCK1/UCK2/CTPS2/TK1	2.82003484422346
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	28/2395	70/9376	1.56592901878914	HIF1A/KRAS/SOS2/MAPK1/RAP1A/EP300/CDC42/CUL2/MAP2K1/MAP2K2/RAF1/PIK3CA/GRB2/PRCC/NRAS/SOS1/VHL/BRAF/GAB1/FH/PIK3CD/CRKL/ARNT/AKT1/ARAF/ETS1/FLCN/PIK3R1	2.78361416312487
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	12/2395	23/9376	2.0425161114641	IDI1/HMGCS1/FNTA/HMGCR/ACAT2/NUS1/ZMPSTE24/PMVK/GGPS1/PDSS1/PDSS2/MVK	2.93191114501269
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	32/2395	83/9376	1.50932917473652	CASP8/CASP3/IRF7/TBK1/IL18/CASP1/POLR2K/ZBP1/PYCARD/ADAR/IFI16/POLR3GL/POLR1D/NFKB1/G3BP1/POLR3K/POLR2H/POLR2F/MLKL/POLR3E/RIPK1/CASP7/CHUK/CGAS/IKBKB/POLR3C/POLR3A/ZCCHC3/FADD/POLR3F/POLR3G/IKBKE	2.72985267280408
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	44/2395	122/9376	1.41190321366234	PRKACB/MDM2/HIF1A/KRAS/ATP2A2/MED13/CTNNB1/MAPK1/EP300/MED4/HDAC1/MED30/MAP2K1/MAP2K2/STAT1/CASP9/RAF1/ATP1A1/NOTCH2/HDAC3/PIK3CA/PFKP/ATP1B1/NRAS/MED14/NCOR1/NCOA3/PIK3CD/NCOA1/MED17/RXRA/KAT2B/GSK3B/MED24/AKT1/SIN3A/MTOR/TP53/KAT2A/MED27/NOTCH1/PLCB1/PLCB3/PIK3R1	2.68219239106415
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	8/2395	13/9376	2.40912156736791	XRCC5/XRCC4/PRKDC/DCLRE1C/XRCC6/FEN1/RAD50/LIG4	2.97777722931402
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	61/2395	181/9376	1.31936008489141	ITGAX/CASP8/CASP3/MALT1/FCER1G/CASP10/IL18/HSPD1/SYK/CAMK2D/IL10RA/ARHGEF12/HSPA9/PPP3CA/MAPK1/BID/PPP3CC/EP300/CYCS/BCL2/RAB5A/IFNGR1/BCL10/NFKB1/STAT1/ITGAM/IRAK4/TCIRG1/CASP9/RAF1/ATP6V1H/PPP3R1/BAX/MAPK9/RFXANK/CEBPG/KSR1/CAMK2G/RFX5/RFXAP/MYD88/CORO1A/JAK2/CALM1/CALM3/APAF1/AKT1/NOD2/IRAK1/JAK1/MAPK8/TRAF6/RIPK2/TLR1/NFYB/TRADD/FADD/NFYA/RHOA/SPHK2/VDR	2.5411109859107
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	50/2395	144/9376	1.35931338436558	GTF2B/PSMA2/PSMD12/OPA1/ATP2A2/PSMA5/VDAC2/VDAC3/ITPR1/NRBF2/CYCS/PSMA6/TBPL1/PSMD13/ATXN2L/XBP1/PSMD6/PSMA1/PSMB2/VDAC1/PSMC4/OMA1/ATXN10/PSMC6/ERN1/PIK3CA/SLC25A5/PUM2/PSMA3/PSMD11/PSMB3/MAPK9/PIK3CD/ATXN1L/PSMC2/PSMD9/TBP/AKT1/MTOR/ATG2B/MAPK8/ATXN3/PSMB1/KAT5/NFYA/PLCB1/PLCB3/PIK3R4/TRAF2/PIK3R1	2.544991411754
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	31/2395	82/9376	1.47999388970925	KLRC1/KLRC2/HSPA5/B2M/KLRD1/HSPA8/CALR/HSPA4/TAP1/KLRC3/KLRC4/PDIA3/HLA-F/HSPA1A/KIR2DL3/HSP90AB1/TAP2/PSME2/HLA-B/KIR2DL4/RFXANK/RFX5/RFXAP/HLA-A/HSP90AA1/HSPA1B/NFYB/NFYA/KIR2DL1/CD8A/HSPA6	2.5569420128162
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	26/2395	67/9376	1.51918486897454	PRKACB/CAMK2D/KRAS/PPP3CA/MAPK1/PPP3CC/RAP1A/PPP1CB/EP300/ITPR1/PPP1CC/MAP2K1/MAP2K2/RAF1/RPS6KA3/NRAS/PPP3R1/BRAF/RPS6KA1/CAMK2G/CAMK4/CALM1/CALM3/ARAF/PLCB1/PLCB3	2.49797156995501
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	41/2395	116/9376	1.38368727953351	ME2/HIBCH/SUCLA2/SUCLG2/SDHD/PGK1/PGP/SDHA/MDH1/PDHA1/IDH2/GLUD1/SDHB/ECHS1/IDH3A/DLD/SUCLG1/RPE/ADPGK/PFKP/PCCA/RPIA/DLST/CAT/PRPS1/PDHB/FH/ACAT2/ALDH6A1/SHMT2/DLAT/SHMT1/ENO1/GOT1/ACADS/PCCB/ALDOA/PSPH/GPT2/TKFC/PSAT1	2.4354570806127
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	8/2395	14/9376	2.23704145541306	B3GNT7/B4GALT1/FUT8/B3GNT2/B4GALT4/B4GALT3/ST3GAL2/ST3GAL3	2.71296087955588
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	30/2395	80/9376	1.46805845511482	BCL2L11/KRAS/EIF4E/SOS2/MAPK1/BCL2/MAP2K1/MAP2K2/STAT3/RAF1/EIF4E2/PTEN/PIK3CA/GRB2/NF1/NRAS/SOS1/BRAF/BAX/RPS6KB1/GAB1/PIK3CD/JAK2/GSK3B/AKT1/MTOR/JAK1/RPS6KB2/ARAF/PIK3R1	2.4625020963536
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	33/2395	90/9376	1.43543493389005	PRKACB/SESN1/KRAS/EIF4E/SESN2/SIRT1/NFKB1/EHMT1/ADCY7/ATF2/ATG5/EIF4E2/ATF6B/PIK3CA/APPL1/CAT/NRAS/BAX/RPS6KB1/PIK3CD/EHMT2/PRKAG1/CAMK4/AKT1/MTOR/TP53/RPS6KB2/ADCY3/TSC1/STK11/PRKAB1/ADCY6/PIK3R1	2.43113883962014
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	27/2395	71/9376	1.48873533476433	GLS/HIF1A/KRAS/SLC1A5/MAPK1/LDHB/PDHA1/MAP2K1/MAP2K2/IDH2/SLC7A5/RAF1/PTEN/PIK3CA/PFKP/SLC16A3/NRAS/TIGAR/PDHB/PIK3CD/AKT1/MTOR/TP53/KIT/LDHA/PIK3R1/SIRT3	2.42116452864762
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2395	37/9376	1.6928962365288	GADD45A/LEF1/KRAS/CTNNB1/MAPK1/MAP2K1/MAP2K2/BAK1/NRAS/DDB2/BRAF/BAX/RXRA/TP53/TCF7/TPM3	2.47342334147801
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	24/2395	62/9376	1.51541517947337	PRKACB/HSPA8/KRAS/HDAC1/HSPA1A/SIRT1/ADCY7/ATG5/PIK3CA/CAT/NRAS/RPS6KB1/PIK3CD/PRKAG1/AKT1/MTOR/HSPA1B/RPS6KB2/SOD1/ADCY3/HSPA6/PRKAB1/ADCY6/PIK3R1	2.38486890349327
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	10/2395	20/9376	1.95741127348643	LBR/MSMO1/CYP51A1/SQLE/FDFT1/HSD17B7/EBP/DHCR24/SC5D/CYP2R1	2.51042936506822
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/2395	109/9376	1.36480052096302	HIF1A/PPP3CA/MAPK1/PPP3CC/CD3E/GATA3/IFNGR1/IL2RB/ZAP70/NFKB1/STAT1/STAT3/HSP90AB1/SMAD4/JAK3/IL27RA/PPP3R1/IRF4/MAPK9/CD247/TBX21/NFATC3/IL2RA/RXRA/LAT/JAK2/IL4R/CHUK/MTOR/JAK1/HSP90AA1/MAPK8/IKBKB/IL2RG/NFKBIE/TYK2/NFATC2/RARA	2.24377185135682
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	33/2395	93/9376	1.38913058118392	CASP3/GADD45A/CKS2/BIRC2/CYCS/TRAF5/BCL2/RB1/NFKB1/CDKN1B/CASP9/PTEN/PIK3CA/BAK1/DDB2/BAX/PIK3CD/CDK2/RXRA/BIRC3/APAF1/AKT1/CHUK/CKS1B/TP53/CDK6/TRAF6/IKBKB/TRAF4/SKP2/FHIT/TRAF2/PIK3R1	2.20888059436199
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	21/2395	54/9376	1.52243099048945	MAT2A/AMD1/MDH1/LDHB/SMS/DNMT1/MTAP/MPST/DNMT3A/ADI1/APIP/MAT2B/ENOPH1/GSS/MRI1/BCAT2/AHCYL2/GOT1/PSAT1/DNMT3B/LDHA	2.25502229469438
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	73/2395	232/9376	1.23181916348715	ITGAX/ARHGEF6/RRAS2/ARPC5L/PIP4K2A/RAC2/ACTR3/ITGB7/KRAS/ARHGEF12/SOS2/ARHGEF1/MAPK1/ACTR2/PPP1CB/PPP1CC/CDC42/VAV3/ARPC1B/MSN/FGD3/GNA13/TMSB4X/MAP2K1/MAP2K2/ITGAM/ARHGEF7/ARPC3/MYL12A/RAF1/LIMK1/SPATA13/PIKFYVE/ABI2/NCKAP1L/PIK3CA/IQGAP2/PXN/CYFIP2/DIAPH1/NRAS/PPP1R12A/SOS1/BRAF/MYL12B/PIK3CD/VAV1/BRK1/CRKL/ITGAD/PIP4K2C/ACTN4/ITGA4/ROCK1/AKT1/ARPC4/PIP5K1A/TIAM1/SSH2/IQGAP1/ARPC5/MRAS/ARPC2/RHOA/CFL1/ARAF/LPAR2/FGF22/WASF1/ACTR3C/DIAPH3/PIK3R1/PFN1	2.09413558254991
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	13/2395	30/9376	1.69642310368824	ATIC/NFKB1/GART/SHMT2/ABCC5/CHUK/DHFR/IKBKB/SHMT1/ABCC1/TYMS/GGH/SLC19A1	2.23769291804822
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	38/2395	112/9376	1.32824336415151	SOCS1/CASP8/CASP3/PIK3R6/GNAI3/HSPA8/IL10RA/PIK3CG/MAPK1/MAP2K3/BIRC2/CYCS/BCL2/HSPA1A/IFNGR1/NFKB1/STAT1/STAT3/IRAK4/CASP9/MAPK9/MYD88/JAK2/MAP2K6/BIRC3/AKT1/CHUK/IRAK1/JAK1/GNAI2/HSPA1B/MAPK8/TRAF6/IKBKB/TYK2/MAP3K7/TAB1/HSPA6	2.04684648398707
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/2395	56/9376	1.46805845511482	B4GALT1/MGAT5/STT3B/ALG13/FUT8/MGAT4A/DDOST/OSTC/DAD1/MOGS/TMEM258/DPM1/ALG8/ALG2/B4GALT3/DPAGT1/ALG11/ALG6/ALG10B/MAN1B1/ALG10	2.05762264205858
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	36/2395	106/9376	1.32956237444361	MDM2/LEF1/KRAS/SOS2/CTNNB1/MAPK1/EP300/BCL2/RB1/MAP2K1/MAP2K2/NFKB1/CDKN1B/HSP90AB1/CASP9/RAF1/PTEN/PIK3CA/GRB2/NRAS/SOS1/BRAF/PIK3CD/CDK2/GSK3B/AKT1/CHUK/MTOR/HSP90AA1/TP53/TCF7/IKBKB/ARAF/GSTP1/SLC19A1/PIK3R1	1.99862017400347
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	9/2395	19/9376	1.85438962751346	PDHA1/DLD/DLST/PDHB/BCKDHB/DLAT/LIAS/DBT/LIPT1	2.18345392083226
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	30/2395	86/9376	1.36563577219984	CAMK2D/KRAS/SOS2/MAPK1/MAP2K1/MAP2K2/CDKN1B/RAF1/PIK3CA/AREG/GRB2/NRAS/SOS1/BRAF/RPS6KB1/MAPK9/GAB1/PIK3CD/NCK1/CAMK2G/CRKL/MAP2K4/GSK3B/AKT1/MTOR/RPS6KB2/MAPK8/ELK1/ARAF/PIK3R1	1.99512277056021
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2395	28/9376	1.6777810915598	HACD4/ACAA2/HADH/THEM4/HADHB/ECHS1/ACOT7/ELOVL6/HACD1/ACOT4/HACD2/ACOT2	2.10372365723809
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	32/2395	93/9376	1.34703571508744	PRKACB/CAMK2D/KRAS/SOS2/MAPK1/MAP2K3/ITPR1/CDC42/MAP2K1/MAP2K2/ADCY7/PTK2B/RAF1/MAP3K1/GRB2/NRAS/SOS1/MAPK9/MAP3K4/CAMK2G/MAP2K6/CALM1/CALM3/MAP2K4/MAPK8/ADCY3/ELK1/PRKCD/PLCB1/GNRH1/PLCB3/ADCY6	1.96993115851994
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	23/2395	63/9376	1.42922092984723	GCDH/HADH/ALDH3A2/NSD1/NSD2/EHMT1/SETD2/ECHS1/EZH2/DLD/PHYKPL/DLST/SUV39H2/NSD3/ACAT2/ALDH9A1/SETDB1/SMYD3/EHMT2/KMT5A/COLGALT2/CAMKMT/TMLHE	2.0021008147948
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	21/2395	57/9376	1.44230304362158	HACD4/ACAA2/HADH/SCP2/ACADM/HADHB/ECHS1/HSD17B4/ACSL3/ELOVL6/ACADVL/HACD1/ACAT2/CBR4/ACACA/HACD2/ACSL5/ACADSB/ACADS/MCAT/SCD5	1.96178892263443
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2395	32/9376	1.59039665970772	ATG12/ATG16L1/IGBP1/ATG5/PPP2CA/GABARAPL2/ATG3/ATG4A/MTOR/ATG2B/ATG4D/ATG4C/PIK3R4	1.95944033643855
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	53/2395	170/9376	1.2205034999386	DPF3/GADD45A/LEF1/SMARCE1/KRAS/SOS2/CTNNB1/MAPK1/CSNK1A1/SMARCA2/TXNRD1/ARID2/PHF10/BRD7/RB1/MAP2K1/MAP2K2/GSTM2/SMARCB1/PBRM1/SMAD4/RAF1/CDKN2A/PTEN/SMARCC1/PIK3CA/SMARCC2/GRB2/BAK1/ACTL6A/NRAS/SOS1/DDB2/BRAF/BAX/RPS6KB1/GAB1/PIK3CD/GSK3B/AKT1/FRAT2/MTOR/TP53/CDK6/RPS6KB2/TCF7/MGST2/ELK1/ARAF/GSTP1/WNT11/PIK3R1/FRAT1	1.6993547143499
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	89/2395	300/9376	1.16139735560195	PRKACB/CASP3/GADD45A/RASA2/RRAS2/DUSP10/PTPN7/RAC2/DDIT3/HSPA8/MAP3K8/KRAS/MKNK2/SOS2/PPP3CA/ELK4/MAPK1/PPP3CC/RAP1A/MAP2K3/CDC42/PPM1B/HSPA1A/DUSP2/MAPKAPK3/MAP2K1/MAP2K2/NFKB1/MKNK1/LAMTOR3/ARRB2/ATF2/CSF1/IRAK4/RAF1/RASGRP1/DUSP5/RPS6KA3/MAP3K1/PPM1A/AREG/GRB2/NF1/NRAS/PPP3R1/SOS1/BRAF/RPS6KA5/DUSP6/MAPK9/MAP3K4/MAPKAPK5/RPS6KA1/FASLG/NFATC3/MYD88/CRKL/MAP2K6/JUND/MAP2K4/AKT1/CHUK/IRAK1/HSPA1B/TP53/MAP4K1/MAPK8/TRAF6/MAP3K12/STK4/IKBKB/MAP3K21/ELK1/EFNA5/MRAS/TRADD/FAS/ARAF/MAP3K7/TAB1/ECSIT/MAP4K3/STMN1/FGF22/KIT/HSPA6/TRAF2/MAP2K5/MAP3K10	1.66413814923162
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	47/2395	149/9376	1.2348769107901	PIK3R6/AGPAT5/RRAS2/FCER1G/ARF6/SYK/PIK3CG/KRAS/SOS2/DGKZ/CYTH4/MAPK1/GNA13/MAP2K1/MAP2K2/ADCY7/PTK2B/RAF1/DGKE/CYTH1/PIK3CA/DGKD/ARF1/GRB2/NRAS/SOS1/GAB1/PIK3CD/AKT1/PIP5K1A/MTOR/DGKH/CYTH2/ADCY3/TSC1/LPAR3/AGPAT2/MRAS/FYN/RHOA/PLCB1/SPHK2/PLCB3/LPAR2/KIT/ADCY6/PIK3R1	1.69271085090964
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/2395	21/9376	1.6777810915598	AASDHPPT/ALDH3A2/PANK2/PANK3/PPCS/PPCDC/DPYD/CSAD/BCAT2	1.82119638019271
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	39/2395	122/9376	1.25145966665526	SOCS1/PRKACB/GNAI3/KRAS/SOS2/MAPK1/EP300/MAP2K3/ITPR1/MAP2K1/MAP2K2/STAT1/SOCS2/ADCY7/STAT3/ATF2/RAF1/ATF6B/MAP3K1/PIK3CA/GRB2/NRAS/SOS1/MAPK9/PIK3CD/CRKL/JAK2/MAP2K6/MAP2K4/GSK3B/AKT1/MTOR/GNAI2/MAPK8/ADCY3/PLCB1/PLCB3/ADCY6/PIK3R1	1.6374312755791
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	21/2395	60/9376	1.3701878914405	RAC2/KRAS/PPP3CA/MAPK1/PPP3CC/CDC42/MAPKAPK3/MAP2K1/MAP2K2/CASP9/RAF1/PIK3CA/PXN/NRAS/PPP3R1/SH2D2A/PIK3CD/AKT1/NFATC2/SPHK2/PIK3R1	1.68485554882885
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	34/2395	105/9376	1.26765682473407	GADD45A/MALT1/CYLD/SYK/TRIM25/BIRC2/ATM/TRAF5/BCL2/ZAP70/CARD11/BCL10/NFKB1/IRAK4/UBE2I/CSNK2A1/CSNK2A2/TNFSF14/MYD88/LAT/CSNK2B/RIPK1/BIRC3/CHUK/IRAK1/TRAF6/IKBKB/TRADD/TNFSF11/MAP3K7/TAB1/PIAS4/TRAF2/TNFAIP3	1.61543414646671
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	97/2395	333/9376	1.14035371488399	OASL/MX1/PRKACB/CCND3/CASP8/MDM2/CASP3/EIF2AK2/TBK1/RBL2/ITGB7/PPP2R5A/KRAS/SOS2/PATJ/CCND2/TADA3/CTNNB1/MAML3/MAPK1/CSNK1A1/EP300/HDAC1/JAG1/CDC42/ATM/UBE3A/TBPL1/HLA-F/RB1/MAP2K1/PPP2R2A/MAP2K2/NFKB1/STAT1/PPP2R2B/CDKN1B/ATP6V1G1/TCIRG1/RAF1/PTEN/PPP2CA/ATP6V1D/COL9A2/ATP6V1H/NOTCH2/ATR/PIK3CA/IRF9/GRB2/RBL1/BAK1/PXN/PPP2R3C/NRAS/HES6/SOS1/HLA-B/BAX/RPS6KB1/IRF1/PIK3CD/ATP6V0E2/MX2/FASLG/LFNG/CDK2/LLGL2/HLA-A/TBP/PPP2R2D/ITGA4/GSK3B/AKT1/CHUK/MTOR/JAK1/TP53/CDK6/RPS6KB2/TCF7/IKBKB/NOTCH1/MFNG/TSC1/CCNA2/TRADD/TYK2/FADD/FAS/ISG15/SCRIB/COL9A3/WNT11/ATP6V1E2/PIK3R1/IKBKE	1.52745822512998
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	46/2395	148/9376	1.21676917000508	GADD45A/LEF1/KRAS/SOS2/CTNNB1/MAPK1/CSNK1A1/JAG1/RB1/MAP2K1/MAP2K2/RAF1/PTEN/NOTCH2/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/RPS6KB1/NCOA3/PIK3CD/JAG2/NCOA1/GSK3B/AKT1/FRAT2/BRCA2/MTOR/DLL1/TP53/CDK6/RPS6KB2/TCF7/NOTCH1/TNFSF11/ARAF/BRCA1/FGF22/KIT/WNT11/PIK3R1/FRAT1	1.55687647942929
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/2395	99/9376	1.26539718690032	RAC2/SLC44A1/HIF1A/KRAS/SOS2/DGKZ/MAPK1/MAP2K1/MAP2K2/GPCPD1/RAF1/WAS/DGKE/PIK3CA/DGKD/GRB2/LYPLA1/NRAS/SOS1/RPS6KB1/MAPK9/PIK3CD/AKT1/PIP5K1A/MTOR/DGKH/RPS6KB2/MAPK8/TSC1/CHKB/WASF1/PIK3R1	1.55485434741323
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/2395	41/9376	1.43225215133153	MDM2/KRAS/RASSF1/MAPK1/DAPK2/RB1/MAP2K1/MAP2K2/RAF1/CDKN2A/NRAS/BRAF/RPS6KA5/TP53/ARAF	1.62461892785191
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	74/2395	250/9376	1.15878747390397	FUCA1/VPS13C/VPS26A/GNPTAB/BLOC1S2/GGA2/AP1G1/CD164/AP1S3/IDS/CTSW/CTSC/STX17/DMXL1/IGF2R/SPG11/OSTM1/VPS13A/CTSA/MANBA/GUSB/LAMTOR3/SORT1/ATP6V1G1/AP5M1/TCIRG1/OSBPL7/AP3S1/PIKFYVE/SLC15A4/ATP6V1D/ATP6V1H/OSBPL3/M6PR/VPS29/MFSD8/BLOC1S6/LAPTM4B/VAMP7/ENTPD4/PLEKHM1/ATP6V0E2/ARL8B/AP3M1/VAMP8/VPS33A/NEU1/LAPTM5/AP3B1/TTI1/AP1S1/CTBS/VPS41/VPS11/MTOR/SNAPIN/BORCS6/GALC/ABCA5/TELO2/VPS39/BLOC1S4/CLN3/ABCA2/AP4S1/AP3S2/SLC36A4/BLOC1S5/RRAGB/TPCN2/AP4B1/AP4M1/ATP6V1E2/TFEB	1.49047806809457
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	58/2395	193/9376	1.17647516955661	PRKACB/XCL1/PIK3R6/ITK/FGR/RAC2/XCL2/CCR1/GNAI3/PIK3CG/KRAS/SOS2/MAPK1/DOCK2/RAP1A/CDC42/VAV3/MAP2K1/NFKB1/STAT1/ARRB2/ADCY7/STAT3/GNG5/PTK2B/RAF1/GNGT2/GRK2/JAK3/WAS/PIK3CA/GRB2/PXN/NRAS/SOS1/CCL28/BRAF/CXCR3/PIK3CD/VAV1/CRKL/JAK2/ROCK1/GSK3B/AKT1/CHUK/TIAM1/GNAI2/IKBKB/ADCY3/PREX1/RHOA/PRKCD/PLCB1/PLCB3/GNG10/ADCY6/PIK3R1	1.45094031607785
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	33/2395	104/9376	1.24220330817408	ETNK1/AGPAT5/DGKZ/PGS1/LPIN1/GPCPD1/LPGAT1/PLPP5/DGKE/LPCAT4/SGMS1/DGKD/LYPLA1/LYPLA2/SELENOI/SGMS2/MBOAT7/CRLS1/CDS2/PISD/PTDSS1/DGKH/PLA2G6/LPCAT3/CEPT1/AGPAT2/PCYT2/PNPLA6/PLB1/GPD2/GPD1L/CHKB/GNPAT	1.45475415733078
Organismal Systems	Immune system	hsa04611	Platelet activation	39/2395	126/9376	1.21173078834874	PRKACB/PIK3R6/FCER1G/GNAI3/SYK/PIK3CG/ARHGEF12/ARHGEF1/LCP2/MAPK1/RAP1A/PPP1CB/ITPR1/PPP1CC/VASP/STIM1/GNA13/ADCY7/MYL12A/RASGRP1/SNAP23/PIK3CA/PPP1R12A/MYL12B/PIK3CD/FERMT3/VAMP8/ROCK1/AKT1/P2RY1/GNAI2/ADCY3/FYN/TLN1/RHOA/PLCB1/PLCB3/ADCY6/PIK3R1	1.40145126144729
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/2395	39/9376	1.40532091429795	MAT2A/MTHFD2/ATIC/MTHFD1/MTHFD2L/DLD/GART/MTHFS/SHMT2/MAT2B/DHFR/SHMT1/AHCYL2/TYMS	1.48561821573968
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/2395	56/9376	1.32824336415151	CUL1/PRKACB/CUL3/SMURF2/CCND2/CSNK1A1/BCL2/CSNK1G3/ARRB2/GRK2/CSNK1D/CSNK1G2/GSK3B/KIF3A/CSNK1G1/BTRC/EFCAB7/SMURF1/MOSMO	1.4429842486617
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/2395	109/9376	1.22113730823007	CASP8/IRF7/TBK1/MAP3K8/MAPK1/MAP2K3/MAP2K1/MAP2K2/NFKB1/STAT1/IRAK4/PIK3CA/IRF9/MAPK9/PIK3CD/MYD88/MAP2K6/RIPK1/MAP2K4/AKT1/CHUK/IRAK1/JAK1/MAPK8/TRAF6/IKBKB/IRF5/TLR1/TYK2/FADD/MAP3K7/TAB1/PIK3R1/IKBKE	1.36014517243999
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	15/2395	43/9376	1.36563577219984	ECI2/GCDH/ACAA2/HADH/ALDH3A2/ACADM/HADHB/ECHS1/ACSL3/ACADVL/ACAT2/ALDH9A1/ACSL5/ACADSB/ACADS	1.40751117472971
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/2395	33/9376	1.42357183526286	PDHA1/IDH2/IDH3A/DLD/DLST/PDHB/BCKDHB/DLAT/BCAT2/GOT1/GPT2/DBT	1.42764572190892
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	43/2395	142/9376	1.18547443323826	SOCS1/CYLD/SYK/ATP2A2/PPP3CA/LCP2/MAPK1/PPP3CC/ITPR1/IFNGR1/MAP2K1/NFKB1/STAT1/CSF1/TEC1/PIK3CA/IRF9/GRB2/PPP3R1/MAPK9/PIK3CD/CAMK4/MAP2K6/JUND/AKT1/CHUK/TYROBP/NCF4/JAK1/MAPK8/TRAF6/IKBKB/SIRPG/TNFSF11/TYK2/TMEM64/NFATC2/FYN/MAP3K7/TAB1/FOSL2/TRAF2/PIK3R1	1.30440624032761
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	25/2395	78/9376	1.25475081633746	ARPC5L/ACTR3/CTNNB1/ACTR2/CDC42/ARPC1B/HCLS1/ARPC3/CD2AP/PIK3CA/PXN/MAD2L2/GAB1/PIK3CD/CRKL/ELMO2/ARHGAP10/ARPC4/ARPC5/ARPC2/RHOA/ARHGEF26/WASF1/ACTR3C/PIK3R1	1.32326764221688
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	34/2395	110/9376	1.21003605997343	CAMK2D/HIF1A/MKNK2/EIF4E/MAPK1/EP300/CUL2/PGK1/BCL2/IFNGR1/LDHB/PDHA1/MAP2K1/MAP2K2/NFKB1/MKNK1/CDKN1B/STAT3/EIF4E2/PIK3CA/PFKP/VHL/RPS6KB1/PDHB/PIK3CD/CAMK2G/ARNT/AKT1/MTOR/RPS6KB2/ENO1/ALDOA/LDHA/PIK3R1	1.29784741237197
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	11/2395	30/9376	1.43543493389005	PIGK/PIGS/PIGN/PIGC/PIGB/PIGG/PIGA/PGAP2/PGAP1/PIGV/PIGL	1.39910589220306
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/2395	157/9376	1.17195324654602	CASP3/PTGER2/CASP1/CD47/CALR/CAMK2D/HIF1A/ATP11B/ODC1/TMEM30A/ATP2A2/ATP8A1/MAPK1/UQCRFS1/RAB5A/DUSP2/ANO6/SIRT1/MAP2K1/MAP2K2/HAVCR2/ADAM10/DUSP5/RAB14/PTPN6/DNMT3A/XKR6/CAMK2G/NFATC3/VPS33A/CRKL/VPS8/ARNT/RXRA/JAK2/VPS41/ARG2/VPS11/CASP7/PLA2G6/VPS39/SIRPG/NFATC2/SPHK2/ANO9/GPR132/PPARD	1.27261745801425
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/2395	27/9376	1.44993427665661	HACD4/SCP2/HSD17B4/ACOT7/ELOVL6/HACD1/ACOT4/HACD2/ACOT2/SCD5	1.37128574024204
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	20/2395	62/9376	1.26284598289447	MAML3/EP300/HDAC1/JAG1/ITCH/DTX3L/SNW1/NOTCH2/TLE3/NUMB/ATXN1L/JAG2/LFNG/KAT2B/DLL1/KAT2A/NOTCH1/MFNG/TLE1/PSEN2	1.21621022425775
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	52/2395	178/9376	1.14365602495836	CUL1/CACYBP/PRKACB/CCND3/CCDC88C/LEF1/RAC2/CAMK2D/CCND2/PPP3CA/CTNNB1/PPP3CC/CSNK1A1/EP300/TBL1XR1/CTNNBIP1/CHD8/SIRT1/SMAD4/SENP2/RYK/TLE3/CSNK2A1/PPP3R1/CSNK2A2/SIAH1/SKP1/RUVBL1/MAPK9/CAMK2G/NFATC3/CSNK2B/GSK3B/FRAT2/INVS/TP53/TCF7/MAPK8/NFATC2/RHOA/BTRC/PLCB1/MAP3K7/TLE1/PLCB3/CCAR2/PPARD/SOST/PORCN/WNT11/BAMBI/FRAT1	1.1333569749055
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/2395	73/9376	1.23343724082707	MDM2/GADD45A/KRAS/MAPK1/RB1/MAP2K1/MAP2K2/RAF1/CDKN2A/PTEN/PIK3CA/BAK1/NRAS/DDB2/BRAF/BAX/PIK3CD/AKT1/TP53/CDK6/ARAF/FGF22/PIK3R1	1.17273433089691
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	59/2395	204/9376	1.13222808956568	PRKACB/MDM2/CASP3/RRAS2/CAMK2D/DDX5/HIF1A/KRAS/ARHGEF12/SOS2/ARHGEF1/CTNNB1/MAPK1/PPP1CB/ITPR1/NUDT16L1/PPP1CC/CDC42/VAV3/MSN/MAP2K1/MAP2K2/PDCD4/HCLS1/STAT3/RAF1/PIK3CA/GRB2/PXN/PTPN6/NRAS/PPP1R12A/SOS1/BRAF/RPS6KB1/GAB1/PIK3CD/VAV1/EIF4B/CAMK2G/FASLG/ROCK1/AKT1/TIAM1/MTOR/TP53/RPS6KB2/IQGAP1/ANK2/ELK1/MRAS/TFAP4/FAS/RHOA/ARAF/CD44/HPSE/WNT11/PIK3R1	1.11837219743782
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/2395	18/9376	1.52243099048945	MMADHC/THAP11/LMBRD1/CD320/MMAB/ZNF143/ZNF76	1.29943105426793
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	68/2395	238/9376	1.11852072770653	RPS10/MX1/OAS2/RPL36A/RPS21/OAS1/RPL37/RPL26/EIF2AK2/RPS19/TBK1/CASP1/RPL22L1/SYK/RPS15A/RSL24D1/MAPK1/RPL41/RPL17/ADAR/NFKB1/STAT1/STAT3/IRAK4/OAS3/RPL14/PIK3CA/IRF9/RPL39/MAPK9/PIK3CD/RPL30/RPL3/MX2/RPS23/MYD88/RPS7/RPS29/RPS18/FAU/CHUK/IRAK1/RPL32/JAK1/CGAS/RPS27L/MAPK8/TRAF6/IKBKB/RPL34/RPL27/RPS25/RPS24/RPL7A/RPLP1/TYK2/MAP3K7/RPL35A/RPS3/ISG15/RPS4X/RPL23A/RPL24/RPL35/RPL36AL/PIK3R1/IKBKE/RPL15	1.08476780966489
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	16/2395	49/9376	1.27830940309318	OGT/B4GALT1/GALNT3/GXYLT1/GALNT1/C1GALT1C1/C1GALT1/LFNG/POGLUT1/GALNT2/B4GALT3/MFNG/COLGALT2/GALNT7/ST3GAL3/XXYLT1	1.14402235132945
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	38/2395	128/9376	1.16221294363257	HPRT1/GMPS/ATIC/PAICS/NTPCR/DCK/PPAT/PGM2/ADCY7/DGUOK/NT5C2/NME3/GART/NUDT5/PNP/PDE7A/PRPS1/NME7/ENTPD4/ADSL/NME1/NUDT2/PAPSS1/NUDT9/PGM1/RRM2B/PDE6D/AK6/AMPD2/NME6/AK9/ADCY3/IMPDH1/AK4/GUCY2D/RRM1/FHIT/ADCY6	1.08229626012321
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	31/2395	103/9376	1.17824756268115	CASP8/GNAI3/CALR/MAPK1/CD3E/IFNGR1/PPP2R2A/NFKB1/PPP2R2B/IRAK4/PPP2CA/PIK3CA/MAPK9/PIK3CD/CD247/FASLG/MYD88/PPP2R2D/MAP2K4/AKT1/CHUK/IRAK1/GNAI2/MAPK8/TRAF6/IKBKB/FADD/FAS/PLCB1/PLCB3/PIK3R1	1.06539746881643
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	41/2395	140/9376	1.14648374589919	PRKACB/PIK3R6/RRAS2/GNAI3/PIK3CG/KRAS/TFAM/MAP1LC3B/MAPK1/ITPR1/JAG1/GNA13/MAP2K1/MAP2K2/ADCY7/GNG5/SMAD4/RAF1/GNGT2/NRAS/RPS6KB1/PRKAG1/CAMK4/CALM1/CALM3/AKT1/MTOR/GNAI2/RPS6KB2/ADCY3/MRAS/HDAC5/PLCB1/SPHK2/PLCB3/PIK3R4/GNG10/NRF1/PRKAB1/ADCY6/LIPE	1.02280082827939
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	42/2395	144/9376	1.14182324286708	CASP8/CASP3/LEF1/TRA2A/TBK1/CTNNB1/MAP2K3/ALDH3A2/ACADM/SIRT1/NFKB1/LPIN1/IRAK4/TRA2B/ACADVL/MAPK9/ALDH9A1/FASLG/MYD88/PRKAG1/MAP2K6/RIPK1/MAP2K4/GSK3B/AKT1/CHUK/IRAK1/TCF7/MAPK8/TRAF6/IKBKB/ACACA/SREBF1/TRADD/FADD/MLYCD/FAS/MAP3K7/TAB1/PRKAB1/IKBKE/SCD5	1.00452404722169
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	36/2395	122/9376	1.15519353845101	PPP2R5A/CAB39/RAB8A/SIRT1/PPP2R2A/PPP2R2B/RAB10/PPP2CA/RAB14/PIK3CA/TBC1D1/PFKP/PPP2R3C/ELAVL1/RPS6KB1/HMGCR/PIK3CD/PRKAG1/PPP2R2D/AKT1/MTOR/STRADB/RPS6KB2/ACACA/TSC1/SREBF1/CCNA2/STK11/MLYCD/MAP3K7/STRADA/CRTC2/PRKAB1/PIK3R1/LIPE/SCD5	1.01057460628807
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/2395	47/9376	1.24941145116155	ME2/ALDH3A2/ACYP1/MDH1/LDHB/PDHA1/DLD/GLO1/PDHB/FH/ACAT2/ALDH9A1/DLAT/ACACA/LDHA	1.00398529001501
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	32/2395	109/9376	1.14930570186359	OGT/PPP1R3B/SLC27A2/PPP1CB/PPP1CC/NFKB1/STAT3/PTEN/RPS6KA3/MLX/PIK3CA/OGA/RPS6KB1/MAPK9/PIK3CD/RPS6KA1/PRKAG1/GSK3B/AKT1/SLC27A5/MTOR/SLC27A3/RPS6KB2/MAPK8/IKBKB/PYGM/PPP1R3E/SREBF1/PRKCD/CRTC2/PRKAB1/PIK3R1	0.918331832981578
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/2395	44/9376	1.245625355855	B4GALT1/STT3B/ALG13/FUT8/MGAT4A/DDOST/OSTC/DAD1/TMEM258/ALG2/B4GALT3/ALG11/MAN1B1/ST3GAL3	0.956514918896295
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	40/2395	139/9376	1.12656763941665	PRKACB/FKBP5/GNAI3/HSPA8/KRAS/FKBP4/SOS2/MAPK1/ITPR1/BCL2/HSPA1A/MAP2K1/MAP2K2/ADCY7/ATF2/HSP90AB1/RAF1/ATF6B/PIK3CA/GRB2/NRAS/SOS1/NCOA3/PIK3CD/NCOA1/CALM1/CALM3/AKT1/HSP90AA1/GNAI2/HSPA1B/ADCY3/POMC/PRKCD/PLCB1/RARA/PLCB3/HSPA6/ADCY6/PIK3R1	0.880530059816556
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/2395	34/9376	1.26656023578534	CUL1/BHLHE40/PER2/CSNK1D/NFIL3/SKP1/CLOCK/PRKAG1/DBP/BTRC/PRKAB1	0.911999224422995
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2395	10/9376	1.56592901878914	MPST/PAPSS1/BPNT1/SUOX	1.0487318673108
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	31/2395	107/9376	1.13420092482391	PRKACB/CAMK2D/SIK1/PPP3CA/PPP3CC/EP300/ITPR1/LDHB/PDHA1/SIRT1/PPP4C/ATF2/PPP4R3A/PPP4R3B/PFKP/PHKG2/PPP3R1/PDHB/CAMK2G/PRKAG1/CALM1/CALM3/AKT1/PYGM/ACACA/PLCB1/PLCB3/PHKA2/CRTC2/PRKAB1/LDHA	0.817731136467151
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	12/2395	38/9376	1.23625975167564	TAP1/CD3E/PTPRC/ZAP70/JAK3/TAP2/RFXANK/DCLRE1C/RFX5/RFXAP/IL2RG/CD8A	0.854740307524044
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/2395	115/9376	1.12338386130526	PRKACB/GNAI3/ARHGEF1/MAPK1/ITPR1/GATA3/STK39/BCL2/GNA13/MAP2K1/ARRB2/ADCY7/ATF2/RAF1/ATF6B/RUNX2/BRAF/OXSR1/RXRA/JUND/BGLAP/GNAI2/ADCY3/NACA/TNFSF11/RHOA/ARAF/PLCB1/PLCB3/VDR/SOST/NR4A2/ADCY6	0.779754542677413
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2395	31/9376	1.26284598289447	HIBCH/CNDP2/ALDH3A2/ECHS1/DPYD/ALDH9A1/ALDH6A1/CSAD/ACADS/MLYCD	0.858562896514837
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/2395	31/9376	1.26284598289447	PGP/MDH1/DLD/PCCA/CAT/ACAT2/SHMT2/SHMT1/PCCB/AFMID	0.858562896514837
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/2395	18/9376	1.30494084899095	FUCA1/MANBA/NEU1/GBA2/NEU3/ENGASE	0.758472632954723
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/2395	51/9376	1.15141839616849	PRKACB/ERO1A/ATP6V1G1/PDIA4/TCIRG1/ATP6V1D/ATP6V1H/SEC61B/ARF1/ATP6V0E2/SEC61A2/ADCY3/SEC61G/SLC12A2/ATP6V1E2	0.635066037241941
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	16/2395	55/9376	1.13885746821029	UGCG/DEGS1/CERS6/SPTLC1/B4GALT5/SGMS1/CERS2/SGMS2/CERS5/NEU1/B4GALNT1/GALC/GBA2/B4GALT6/SPHK2/NEU3	0.604921348090104
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	20/2395	70/9376	1.11852072770653	NFKB1/STAT3/APPL1/ACSL3/MAPK9/PRKAG1/RXRA/JAK2/AKT1/CHUK/MTOR/MAPK8/IKBKB/ACSL5/NFKBIE/STK11/TRADD/POMC/TRAF2/PRKAB1	0.582963526015422
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/2395	15/9376	1.30494084899095	SLC33A1/ST6GALNAC4/ST6GALNAC6/B4GALNT1/ST3GAL2	0.69227666060823
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2395	15/9376	1.30494084899095	ACP1/NTPCR/AK4/NFS1/TPK1	0.69227666060823
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/2395	78/9376	1.10418071837696	CASP3/IRF8/CASP1/GNAI3/PYCARD/MAPK1/NFKB1/ITGAM/IRAK4/MAPK9/IRF1/MYD88/CALM1/CALM3/CASP7/IRAK1/GNAI2/MAPK8/TRAF6/RHOA/CFL1/NOD1	0.541152234772533
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	41/2395	150/9376	1.07005149617258	GADD45A/LEF1/ABCB1/KRAS/SOS2/CTNNB1/MAPK1/CSNK1A1/BCL2/RB1/MAP2K1/MAP2K2/CDKN1B/SMAD4/RAF1/PIK3CA/GRB2/BAK1/NRAS/SOS1/DDB2/BRAF/BAX/RPS6KB1/GAB1/PIK3CD/CDK2/MLH1/RXRA/GSK3B/AKT1/FRAT2/MTOR/TP53/RPS6KB2/TCF7/ARAF/FGF22/WNT11/PIK3R1/FRAT1	0.50656583755306
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	46/2395	170/9376	1.05930492447501	PRKACB/ARPC5L/ACTR3/RAP2C/HSPA4/RAB8B/WHAMM/PATJ/RAB8A/ACTR2/RAP1A/VASP/CDC42/ARPC1B/MSN/TUBA4A/PPP2R2A/PPP2R2B/HCLS1/ARPC3/MYL12A/PPP2CA/WAS/MAP3K1/MAPK9/MYL12B/LLGL2/PRKAG1/ARHGAP17/PPP2R2D/ACTN4/ROCK1/ARPC4/TIAM1/PCNA/MAPK8/ARPC5/STK11/ARPC2/TUBA1B/RHOA/SCRIB/TJAP1/PRKAB1/ACTR3C/OCLN	0.457045366712252
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/2395	42/9376	1.11852072770653	MAP1LC3B/VDAC2/VDAC3/SLC3A2/ATG5/SAT2/ACSL3/GSS/TP53/LPCAT3/SLC39A8/ACSL5	0.45088380281313
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/2395	27/9376	1.15994742132529	HMGCS1/HADH/OXCT1/ECHS1/AACS/ACAT2/BDH1/ACADS	0.487479237371487
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	9/2395	31/9376	1.13656138460502	PGM2/RPE/PFKP/RPIA/DERA/PRPS1/PGM1/ALDOA/RBKS	0.446065549975093
NA	NA	hsa04981	Folate transport and metabolism	9/2395	31/9376	1.13656138460502	MTHFD1/MTHFS/SHMT2/ABCC5/DHFR/SHMT1/ABCC1/TYMS/SLC19A1	0.446065549975093
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/2395	20/9376	1.17444676409186	UAP1/GMDS/UGP2/CYB5R4/TGDS/GMPPA	0.457417090591148
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	24/2395	89/9376	1.05568248457695	PRKACB/GNAI3/KRAS/SOS2/MAPK1/ITPR1/TUBA4A/MAP2K1/MAP2K2/ADCY7/RAF1/CSNK1D/GRB2/NRAS/SOS1/GNAI2/ADCY3/TUBA1B/PLCB1/ADRB1/PLCB3/ADCY6/CDK1/MAP2K5	0.309140186124592
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	22/2395	82/9376	1.05031824430979	HPRT1/GMPS/GSTM2/GUSB/TPMT/NME3/UPP1/NME7/DPYD/NME1/CDADC1/UMPS/RRM2B/NAT1/MGST2/NME6/IMPDH1/RRM1/GSTP1/UCK1/UCK2/TK1	0.26804681402255
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/2395	36/9376	1.08745070749246	GCNT1/GALNT3/GALNT1/C1GALT1C1/B4GALT5/C1GALT1/ST6GALNAC4/GALNT2/ST3GAL2/GALNT7	0.30790781913535
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	25/2395	94/9376	1.04117620930129	CASP8/CASP3/TBK1/MAPK1/SRSF1/ANAPC5/TRAF5/NFKB1/HSP90AB1/ELAVL1/MAPK9/JUND/GSK3B/CHUK/HSP90AA1/MAPK8/TRAF6/IKBKB/TRAF4/TRADD/FADD/MAP3K7/TRAF2/TNFAIP3/IKBKE	0.235000661966302
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	29/2395	110/9376	1.03208958056557	CUL1/ID3/ID2/SMURF2/MAPK1/EP300/TFDP1/HDAC1/LEMD3/SKIL/SMAD4/PPP2CA/SKI/RBL1/SMAD5/SKP1/RPS6KB1/NCOR1/SMAD7/ROCK1/SIN3A/E2F4/RPS6KB2/E2F5/RHOA/ACVR1B/BMPR1A/SMURF1/BAMBI	0.198286804210659
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	26/2395	99/9376	1.02813521435651	PRKACB/PTGER2/CAMK2D/PPP1CB/MAP2K3/ITPR1/PPP1CC/ADCY7/PIK3CA/TRPV2/MAPK9/PIK3CD/CAMK2G/PRKCH/MAP2K6/CALM1/CALM3/PLA2G6/MAPK8/ADCY3/PRKCD/PLCB1/PLCB3/ADCY6/CYP2J2/PIK3R1	0.164832795963476
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	52/2395	201/9376	1.0127899126497	GZMB/MDM2/GADD45A/DDIT3/ITGB7/ID2/DDX5/FUT8/CDKN2C/CCND2/ELK4/SS18/HDAC1/JMJD1C/BIRC2/ATM/TAF15/IL2RB/NSD2/KDM6A/NFKB1/ITGAM/CCNT2/CDKN1B/CDK9/PER2/SIX4/RUNX2/HOXA9/SUPT3H/CCNT1/PML/BAK1/PRCC/ETV6/DDB2/BAX/FLI1/DUSP6/MLLT3/NCOR1/HOXA10/RXRA/BIRC3/SIN3A/TP53/CCNA2/SS18L1/RARA/FUS/TCF3/LDB1	0.107359912468423
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	56/2395	217/9376	1.01027678631558	PRKACB/CCND3/PTGES3/GNAI3/KRAS/SOS2/KPNA4/KPNA2/MAPK1/JAG1/BCL2/RB1/MAP2K1/MAP2K2/GSTM2/NFKB1/ARRB2/ADCY7/STAT3/ATF2/HSP90AB1/RAF1/ATF6B/KPNA1/NOTCH2/RPS6KA3/KPNA3/PIK3CA/GRB2/NRAS/SOS1/RPS6KB1/PIK3CD/RPS6KA1/AIP/ARNT/RXRA/JAK2/AKT1/MTOR/DLL1/HSP90AA1/GNAI2/RPS6KB2/MGST2/KPNA5/ADCY3/TNFSF11/CDC6/ADRB1/VDR/FGF22/ADCY6/BIRC5/PIK3R1/IKBKE	0.089710389413169
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2395	18/9376	1.08745070749246	ACSL3/CBR4/ACACA/ACSL5/MCAT	0.217514211641511
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/2395	116/9376	1.01245410697574	ITK/RAC2/TXK/GNAI3/CTNNB1/RHOH/RAP1A/VASP/CDC42/VAV3/RASSF5/MSN/ITGAM/SIPA1/MYL12A/PTK2B/PIK3CA/PXN/MYL12B/PIK3CD/VAV1/ACTN4/ITGA4/ROCK1/NCF4/GNAI2/CD99/RHOA/PIK3R1/OCLN	0.0790525113411378
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	26/2395	101/9376	1.00777610120093	PRKACB/LEF1/GNAI3/CAMK2D/KRAS/CTNNB1/MAPK1/EP300/MAP2K1/MAP2K2/ADCY7/RAF1/NRAS/CAMK2G/CALM1/CALM3/GSK3B/GNAI2/TCF7/ADCY3/POMC/PLCB1/PLCB3/KIT/ADCY6/WNT11	0.0460198511729001
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	43/2395	168/9376	1.00200815190377	SOCS1/PIM1/CCND3/STAM/IL10RA/SOCS4/SOS2/CCND2/EP300/PTPN2/STAT4/BCL2/CISH/IFNGR1/IL2RB/STAT1/SOCS2/MCL1/STAT3/OSM/RAF1/JAK3/PIK3CA/IRF9/IL27RA/GRB2/PTPN6/SOS1/PIK3CD/STAM2/IL2RA/JAK2/IL4R/AKT1/MTOR/JAK1/IL2RG/TYK2/PIAS4/SOCS6/IFNL1/SOCS7/PIK3R1	0.0153832509532134
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	54/2395	212/9376	0.99717178083271	PRKD3/RAC2/GNAI3/KRAS/EVL/CTNNB1/LCP2/MAPK1/RAP1A/MAP2K3/VASP/CDC42/VAV3/RASSF5/MAP2K1/MAP2K2/ITGAM/SIPA1/ADCY7/RGS14/CSF1/RAF1/SKAP1/PIK3CA/NRAS/BRAF/PIK3CD/SIPA1L1/VAV1/CRKL/LAT/MAP2K6/CALM1/CALM3/AKT1/P2RY1/TIAM1/GNAI2/ADCY3/LPAR3/EFNA5/MRAS/TLN1/RHOA/PLCB1/FARP2/SIPA1L3/PLCB3/LPAR2/FGF22/KIT/ADCY6/PIK3R1/PFN1	-0.0243959665664023
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2395	23/9376	1.02125805573205	GLS/GLUD1/ARG2/GOT1/GPT2/CAD	0.0597849086807573
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/2395	47/9376	0.999529160929241	SOCS1/SOCS4/MAPK1/SOCS2/PIK3CA/MAPK9/PIK3CD/MTOR/MAPK8/IKBKB/PRKCD/PIK3R1	-0.00189532396690298
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/2395	59/9376	0.995293867874456	ODC1/LAP3/GSR/GSTM2/TXNDC12/SMS/IDH2/GGCT/GSTK1/RRM2B/GSS/MGST2/RRM1/CHAC2/GSTP1	-0.0212388820003817
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/2395	67/9376	0.993313183560278	ALDH3A2/PGK1/LDHB/PDHA1/PGM2/DLD/ADPGK/PFKP/GAPDHS/PDHB/ALDH9A1/DLAT/PGM1/ENO1/ALDOA/MINPP1/LDHA	-0.0321725041658573
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/2395	75/9376	0.991755045233125	MAT2A/PGK1/IDH2/IDH3A/RPE/PFKP/RPIA/PRPS1/SHMT2/MAT2B/ARG2/SHMT1/ENO1/BCAT2/GOT1/ALDOA/PSPH/GPT2/PSAT1	-0.0419888195171258
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	29/2395	115/9376	0.987216120540982	PRKACB/PIK3R6/GNAI3/CAMK2D/PIK3CG/KRAS/MAPK1/ITPR1/BCL2/MAP2K1/ADCY7/GNG5/GNGT2/PIK3CA/NRAS/PIK3CD/CAMK2G/CAMK4/JAK2/AKT1/GNAI2/ADCY3/KCNQ5/FYN/PLCB1/PLCB3/GNG10/ADCY6/PIK3R1	-0.0807908585106425
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/2395	60/9376	0.978705636743215	GNAI3/KRAS/MAPK1/ITPR1/GNA13/MAP2K1/MAP2K2/RAF1/PPP2CA/NRAS/BRAF/GNAI2/ARAF/PLCB1/PLCB3	-0.0969181513537914
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/2395	44/9376	0.978705636743215	PRKACB/RAB5A/STX4/NSF/DYNLL1/VAMP2/DCTN6/ARHGDIB/ADCY3/ADCY6/AQP3	-0.0829245664504435
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/2395	28/9376	0.978705636743215	B4GALT1/B3GNT2/B4GALT4/A4GALT/B4GALT3/ST3GAL3/B3GALNT1	-0.066094283695679
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/2395	45/9376	0.956956622593366	ABCB1/TAP1/ABCD3/TAP2/ABCG1/ABCC5/ABCA5/ABCC1/ABCA2/ABCC10/ABCD2	-0.169522786047353
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/2395	45/9376	0.956956622593366	KLRC1/GZMB/KLRD1/PRF1/HLA-F/KIR2DL3/HLA-B/FASLG/HLA-A/FAS/KIR2DL1	-0.169522786047353
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	41/2395	166/9376	0.966914002565586	PIK3R6/GNAI3/PIK3CG/ATP2A2/PPP3CA/MAPK1/PPP3CC/PPP1CB/VDAC2/VDAC3/ITPR1/PPP1CC/VASP/GTF2I/GNA13/MAP2K1/MAP2K2/ADCY7/VDAC1/ATF2/RAF1/ATP1A1/ATF6B/SLC25A5/ATP1B1/PPP3R1/PPP1R12A/NFATC3/CALM1/CALM3/ROCK1/AKT1/GNAI2/ADCY3/NFATC2/RHOA/PLCB1/ADRB1/PLCB3/KCNMB4/ADCY6	-0.251911525996933
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	38/2395	154/9376	0.965995173928368	PRKACB/PIK3R6/CD38/GNAI3/CAMK2D/PIK3CG/KRAS/CAMK1/PPP3CA/MAPK1/PPP3CC/PPP1CB/ITPR1/PPP1CC/MAP2K1/MAP2K2/ADCY7/RAF1/NRAS/PPP3R1/PPP1R12A/CAMK2G/NFATC3/PRKAG1/CAMK4/CALM1/CALM3/ROCK1/GNAI2/ADCY3/ELK1/NFATC2/RHOA/PLCB1/PLCB3/PRKAB1/ADCY6/MAP2K5	-0.24921141862884
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/2395	37/9376	0.952254133047453	UAP1/PGM2/GALE/GMDS/UGP2/PGM1/PMM2/TGDS/GMPPA	-0.170437845601757
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/2395	130/9376	0.963648626947166	PRKACB/GNAI3/KRAS/SOS2/MAPK1/MAP2K1/MAP2K2/NFKB1/ARRB2/ADCY7/GNG5/ATF2/RAF1/GNGT2/ATF6B/PIK3CA/GRB2/NRAS/SOS1/MAPK9/PIK3CD/MAP2K4/AKT1/GNAI2/MAPK8/ADCY3/PLCB1/PLCB3/GNG10/RLN2/ADCY6/PIK3R1	-0.244452863667775
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	59/2395	238/9376	0.970481219627726	PRKACB/RASA2/RRAS2/TBK1/ARF6/RAC2/KRAS/RASSF1/SOS2/MAPK1/RAP1A/SHOC2/CDC42/RASSF5/RASAL3/RAB5A/ZAP70/MAP2K1/MAP2K2/NFKB1/RALGAPA1/GNG5/CSF1/RAF1/GNGT2/RASGRP1/PIK3CA/GRB2/NF1/NRAS/SOS1/BRAP/MAPK9/GAB1/PIK3CD/KSR1/EXOC2/FASLG/RALGAPA2/LAT/CALM1/CALM3/AKT1/CHUK/TIAM1/PLA2G6/MAPK8/STK4/IKBKB/ELK1/EFNA5/MRAS/RGL2/RHOA/ETS1/FGF22/KIT/GNG10/PIK3R1	-0.270172343252041
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/2395	50/9376	0.939557411273486	ODC1/LAP3/AMD1/CNDP2/ALDH3A2/SMS/SAT2/ALDH9A1/OAT/ARG2/GOT1/AGMAT	-0.250992030145479
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/2395	21/9376	0.93210060642211	CHST12/CSGALNACT2/CHST11/XYLT1/CHST14	-0.182445529008128
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/2395	42/9376	0.93210060642211	GCDH/HADH/ALDH3A2/ECHS1/DLD/DLST/CAT/ACAT2/ALDH9A1/AFMID	-0.258307026775179
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	35/2395	144/9376	0.951519369055903	ID3/JARID2/ID2/KRAS/CTNNB1/MAPK1/ZFHX3/PCGF5/SKIL/MAP2K1/MAP2K2/STAT3/SMAD4/SMARCAD1/RAF1/JAK3/PIK3CA/GRB2/SMAD5/NRAS/PIK3CD/SETDB1/REST/JAK2/GSK3B/AKT1/JAK1/TCF7/PCGF6/ACVR1B/BMPR1A/TCF3/HOXA1/WNT11/PIK3R1	-0.343384896744084
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/2395	71/9376	0.937351877444206	CASP3/CDC42/NFKB1/ATP6V1G1/ADAM10/TCIRG1/CSK/ATP6V1D/ATP6V1H/MAPK9/ATP6V0E2/MAP2K4/CHUK/MAPK8/IKBKB/ATP6V1E2/NOD1	-0.310354912626892
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/2395	17/9376	0.921134716934791	SCP2/HSD17B4/SLC27A5/ACOT8	-0.19062294795481
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/2395	59/9376	0.928940943349492	PRKACB/GNAI3/PTGER3/ADCY7/ABHD5/PIK3CA/PIK3CD/AKT1/GNAI2/ADCY3/ADRB1/ADCY6/PIK3R1/LIPE	-0.320691149121552
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/2395	149/9376	0.945863165711563	PRKACB/GNAI3/NDUFC2/NDUFB5/NDUFB3/MAPK1/ITPR1/NDUFA9/NDUFB8/NDUFA13/NDUFV2/NDUFS4/NDUFAB1/ADCY7/GNG5/GNGT2/NDUFA10/NDUFA2/NDUFA8/NDUFA6/NDUFA12/NDUFB6/MAPK9/NDUFS3/NDUFA7/NDUFB4/GNAI2/MAPK8/ADCY3/PLCB1/NDUFA4/PLCB3/GNG10/ADCY6/GABRD/NAPEPLD	-0.390153321268039
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/2395	101/9376	0.930254862647016	PIM1/CASP3/KRAS/MAPK1/CDC42/BCL2/NFKB1/STAT1/CDKN1B/STAT3/SMAD4/PIK3CA/DIAPH1/NRAS/BAX/MAPK9/PIK3CD/JAK2/AKT1/MAPK8/PRKCD/PLCB1/PLCB3/PIK3R1	-0.412759653980856
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2395	35/9376	0.894816582165225	GMDS/PFKP/TIGAR/PMM2/GMPPA/ALDOA/TKFC/KHK	-0.365144020291769
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	44/2395	183/9376	0.941268809108229	XPO1/NOP10/NOP58/XRN1/RIOK2/POP5/RAN/NMD3/UTP18/GNL3L/NXT1/RIOK1/RPP30/GNL3/GTPBP4/EFL1/UTP6/NXF1/BMS1/CSNK2A1/XRN2/EIF6/CSNK2A2/HEATR1/WDR3/NAT10/WDR36/UTP14A/NOB1/POP7/RCL1/CSNK2B/DKC1/RPP25L/AK6/RPP38/WDR75/POP4/PWP2/UTP15/NXT2/REXO5/RMRP/RPP40	-0.469943124451127
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/2395	69/9376	0.907784938428489	PRKACB/CAMK2D/PPP3CA/PPP3CC/PPP1CB/PPP1CC/HDAC1/SIRT1/ATF2/ATF6B/PPP3R1/CAMK2G/CAMK4/CALM1/CALM3/STX1A	-0.450299149872491
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/2395	65/9376	0.903420587762968	KRAS/MAPK1/ITPR1/MAP2K1/MAP2K2/ARRB2/RAF1/PIK3CA/NRAS/PIK3CD/AKT1/PLCB1/GNRH1/PLCB3/PIK3R1	-0.457638602914868
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2395	23/9376	0.851048379776709	GLS/MDH1/GLUD1/ATP1A1/ATP1B1	-0.418902797374565
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/2395	133/9376	0.912477435760591	PRKACB/GNAI3/PPP2R5A/CAMK2D/PPP3CA/PPP3CC/PPP1CB/ITPR1/PPP1CC/PPP2R2A/PPP2R2B/ARRB2/GNG5/ATF2/GNGT2/PPP2CA/ATF6B/PPP2R3C/MAPK9/CLOCK/CAMK2G/PPP2R2D/CALM1/CALM3/GSK3B/AKT1/GNAI2/MAPK8/PLCB1/PLCB3/GNG10	-0.595413880956737
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/2395	28/9376	0.838890545779899	GCH1/QDPR/DHFR/MOCS2/GGH/GPHN	-0.500057871882433
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	48/2395	203/9376	0.925672326377819	CCND3/RAC2/ITGB7/SOS2/CCND2/CTNNB1/MAPK1/RAP1A/PPP1CB/PPP1CC/VASP/CDC42/BIRC2/VAV3/PARVG/CAPN2/BCL2/MAP2K1/MYL12A/RAF1/PTEN/COL9A2/PIK3CA/GRB2/PXN/DIAPH1/PPP1R12A/SOS1/BRAF/MAPK9/MYL12B/PIK3CD/VAV1/CRKL/ACTN4/BIRC3/ITGA4/ROCK1/GSK3B/AKT1/PIP5K1A/MAPK8/ELK1/FYN/TLN1/RHOA/COL9A3/PIK3R1	-0.627079264563311
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/2395	37/9376	0.846448118264402	GLS/PPAT/GLUD1/ADSL/GOT1/GPT2/CAD/ASRGL1	-0.548132300898866
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	43/2395	184/9376	0.914877008259962	SRGAP3/SEMA4D/RAC2/GNAI3/CAMK2D/KRAS/ARHGEF12/PPP3CA/MAPK1/PPP3CC/CDC42/PLXNA4/MYL12A/RAF1/LIMK1/RGS3/PIK3CA/RYK/SRGAP2/NRAS/PPP3R1/MYL12B/PIK3CD/NCK1/CAMK2G/NFATC3/ROCK1/GSK3B/GNAI2/CDK5/SSH2/PLXNC1/EPHA1/EFNA5/LRIG2/NFATC2/FYN/RHOA/CFL1/EPHB6/LRRC4/EPHB3/PIK3R1	-0.683015187441259
NA	NA	hsa04517	IgSF CAM signaling	71/2395	299/9376	0.929606691756097	ITGAX/SRGAP3/DOK2/SH2D1B/ARPC5L/ARF6/NCAM1/ACTR3/CD96/MBP/ICAM3/CTNNB1/LCP2/CASK/MAPK1/ACTR2/RAP1A/CD2/CDC42/VAV3/ARPC1B/INPP5D/MSN/TUBA4A/SPTAN1/MAP2K1/MAP2K2/PLXNA4/ITGAM/ARPC3/MYL12A/CSK/CRTAM/CD2AP/PIK3CA/GRB2/PXN/PTPN6/SRGAP2/DYNLL1/MAPK9/MYL12B/PIK3CD/VAV1/NCK1/CD48/CABLES1/SSX2IP/ACTN4/ITGA4/GSK3B/AKT1/NECTIN1/ARPC4/LMO7/MAPK8/NECTIN3/TRAF6/IQGAP1/ARPC5/MTSS1/ANK2/ARPC2/TUBA1B/FYN/RHOA/CD226/CD244/DOK1/ACTR3C/PIK3R1	-0.7245617114232
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/2395	38/9376	0.82417316778376	UAP1/PGM2/GALE/UGP2/GNPDA2/PGM1/PMM2/GMPPA	-0.636106148311774
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/2395	38/9376	0.82417316778376	CD38/NNT/SIRT1/SIRT2/NT5C2/PNP/SIRT5/SIRT3	-0.636106148311774
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/2395	52/9376	0.82813553878272	APOC2/VDAC2/VDAC3/VAPA/SORT1/VDAC1/STARD3NL/MYLIP/STARD3/LDLRAP1/CIDEB	-0.727890746580701
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/2395	78/9376	0.85323055510947	MAPK1/IFNGR1/NFKB1/STAT1/ITGAM/IRAK4/PTPN6/MYD88/JAK2/ITGA4/IRAK1/NCF4/JAK1/TRAF6/ELK1/MAP3K7/TAB1	-0.762373444301372
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2395	16/9376	0.734029227557411	A4GALT/ST3GAL2/B3GALNT1	-0.623642292904994
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/2395	87/9376	0.854961245890625	COX6A2/ATP2A2/UQCRC2/UQCRFS1/COX5A/ATP1A1/COX7A2L/ATP1B1/COX7B/CYC1/UQCR10/COX7A2/UQCRH/ASPH/COX7C/COX6A1/TPM3/TPM4/COX8A	-0.796047134605945
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/2395	70/9376	0.838890545779899	CASP8/CASP3/RAC2/BID/CD55/CYCS/PRF1/HLA-F/EIF4G2/CASP9/EIF4G3/HLA-B/SNTB1/HLA-A/FYN	-0.792443122177983
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	35/2395	155/9376	0.88399218802613	PRKACB/LEF1/GNAI3/CAMK2D/CDKN2C/CTNNB1/MAPK1/RAP1A/ITPR1/RB1/MAP2K1/MAP2K2/ADCY7/CDKN1B/ATF2/CDKN2A/ATF6B/BRAF/FH/ASH2L/CAMK2G/CDK2/RBBP5/AIP/ARNT/GSK3B/GNAI2/CDK6/TCF7/ADCY3/POMC/PLCB1/PLCB3/ADCY6/WNT11	-0.852989434377639
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/2395	44/9376	0.800759157335358	GZMB/HSPD1/PRF1/HLA-F/HLA-B/FASLG/HLA-A/PTPRN2/FAS	-0.775884223348269
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2395	26/9376	0.752850489802473	LMBRD1/SLC19A2/ABCC1/PLB1/SLC19A1	-0.739128929223747
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	16/2395	75/9376	0.83516214335421	PRKACB/HSPA5/ITPR1/GSR/ADCY7/ATF2/PDIA4/ATP1A1/ATF6B/TTF2/ATP1B1/ADCY3/PLCB1/PLCB3/ADCY6/ASGR2	-0.839464522000395
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/2395	17/9376	0.690851037701093	TXNRD1/SEPHS2/PAPSS1	-0.74723483211062
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/2395	17/9376	0.690851037701093	CA5B/GLUD1/CA13	-0.74723483211062
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	35/2395	157/9376	0.872731141044905	CCND3/LEF1/TP53BP2/ID2/RASSF1/MOB1A/PATJ/CCND2/CTNNB1/PPP1CB/PPP1CC/BIRC2/PPP2R2A/PPP2R2B/SMAD4/PPP2CA/YWHAZ/CSNK1D/AREG/LATS1/LLGL2/SMAD7/PPP2R2D/BIRC3/GSK3B/TCF7/MOB1B/BBC3/BTRC/BMPR1A/SCRIB/YWHAB/LIMD1/WNT11/BIRC5	-0.94191051940659
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2395	22/9376	0.711785917631429	CNDP2/ALDH3A2/CARNMT1/ALDH9A1	-0.792697398047161
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/2395	12/9376	0.652470424495477	GGCX/COQ5	-0.705555641029016
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/2395	12/9376	0.652470424495477	NCAM1/CD46	-0.705555641029016
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/2395	98/9376	0.838890545779899	PRKACB/PRKD3/CAMK2D/CAMK1/ITPR1/ADCY7/ATF2/ATP1A1/ATF6B/ATP1B1/CAMK2G/CAMK4/CALM1/CALM3/ADCY3/POMC/PLCB1/PLCB3/NR4A2/ADCY6/LIPE	-0.939045115998186
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/2395	154/9376	0.864311471409592	PRKACB/PIK3R6/GNAI3/PPP2R5A/CAMK2D/PIK3CG/ATP2A2/MAPK1/PPP1CB/PPP1CC/BCL2/PPP2R2A/PPP2R2B/ADCY7/ATF2/ATP1A1/PPP2CA/ATF6B/ATP1B1/PPP2R3C/RPS6KA5/CAMK2G/PPP2R2D/CALM1/CALM3/AKT1/GNAI2/ADCY3/TPM3/PLCB1/TPM4/ADRB1/PLCB3/ADCY6	-0.994421516241344
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/2395	32/9376	0.734029227557411	B4GALT1/PGM2/GALE/PFKP/UGP2/PGM1	-0.882718171365882
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	84/2395	362/9376	0.908411861728509	CCND3/MDM2/PIK3AP1/PIK3R6/BCL2L11/RBL2/ITGB7/SYK/PPP2R5A/PIK3CG/KRAS/EIF4E/SOS2/DDIT4/CCND2/MAPK1/THEM4/BCL2/IL2RB/MAP2K1/PPP2R2A/MAP2K2/NFKB1/PPP2R2B/MCL1/CDKN1B/GNG5/ATF2/CSF1/HSP90AB1/CASP9/OSM/RAF1/GNGT2/EIF4E2/PTEN/JAK3/PPP2CA/ATF6B/PKN2/COL9A2/YWHAZ/PIK3CA/AREG/GRB2/PPP2R3C/NRAS/SOS1/RPS6KB1/PIK3CD/EIF4B/FASLG/CDK2/IL2RA/RXRA/JAK2/PPP2R2D/ITGA4/GSK3B/IL4R/AKT1/CHUK/MTOR/JAK1/HSP90AA1/TP53/CDK6/RPS6KB2/IKBKB/PHLPP1/TSC1/LPAR3/EFNA5/IL2RG/STK11/BRCA1/LPAR2/FGF22/YWHAB/KIT/GNG10/COL9A3/CRTC2/PIK3R1	-1.04091272462745
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/2395	46/9376	0.765943541799038	ALAS1/GUSB/FXN/COX10/MMAB/PPOX/FECH/CPOX/COX15	-0.932048047342402
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/2395	142/9376	0.854644358846188	RAC2/CTNNB1/SUMO1/BCL2/GSTM2/NFKB1/SUMO2/HSP90AB1/PIK3CA/TXN2/MAPK9/PIK3CD/MAP2K6/CALM1/CALM3/MAP2K4/AKT1/SUMO4/CHUK/HSP90AA1/TP53/MAPK8/MGST2/IKBKB/RHOA/MAP3K7/PIAS4/BMPR1A/GSTP1/MAP2K5/PIK3R1	-1.02225844326635
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/2395	37/9376	0.740642103481352	IL18/FASLG/MYD88/THOP1/FAS/PLCB1/PLCB3	-0.925826756195976
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/2395	69/9376	0.794311821124928	PRKACB/PTGER2/GNAI3/PPP3CA/PPP3CC/ITPR1/PPP3R1/CALM1/CALM3/GNAI2/PLCB1/ADRB1/PLCB3/ADCY6	-1.00440438370732
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/2395	23/9376	0.680838703821367	B4GALT1/B4GALT3/POMGNT1/ST3GAL3	-0.897590503429888
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/2395	23/9376	0.680838703821367	LNPEP/CTSA/PREP/THOP1	-0.897590503429888
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/2395	28/9376	0.699075454816582	ATP6V1G1/TCIRG1/ATP6V1D/ATP6V0E2/ATP6V1E2	-0.934021460069187
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/2395	65/9376	0.782964509394572	AGPAT5/DGKZ/AGK/ALDH3A2/LPIN1/PLPP5/DGKE/DGKD/ALDH9A1/DGKH/AGPAT2/TKFC/GK	-1.02841606097005
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/2395	38/9376	0.72115152181079	KRAS/MAPK1/ATP1A1/PIK3CA/ATP1B1/PIK3CD/PIK3R1	-1.00881776227073
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/2395	29/9376	0.674969404650493	RASSF1/MOB1A/LATS1/MOB1B/LIMD1	-1.02675469878604
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/2395	48/9376	0.734029227557411	ATP1A1/PIK3CA/ATP1B1/PIK3CD/AKT1/PLCB1/PLCB3/SLC37A4/PIK3R1	-1.08203134687945
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/2395	19/9376	0.61812987583782	IDS/GUSB/HPSE	-0.975896468075366
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/2395	39/9376	0.702660457148975	GZMB/PRF1/HLA-F/HLA-B/FASLG/HLA-A/FAS	-1.08983530219335
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/2395	76/9376	0.772662344797275	PRKACB/GNAI3/CAMK2D/ITPR1/ADCY7/ATP1A1/ATP1B1/CAMK2G/CALM1/CALM3/GNAI2/ADCY3/PLCB1/PLCB3/ADCY6	-1.16551073034591
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2395	36/9376	0.652470424495477	PGM2/GYG1/UGP2/PGM1/GBE1/PYGM	-1.22362730670711
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/2395	41/9376	0.668384337288049	ALAS1/DLD/SHMT2/SHMT1/PSPH/PSAT1/GCAT	-1.2463768676556
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	19/2395	97/9376	0.766820911262725	PRKACB/GNAI3/CAMK2D/MAPK1/ITPR1/ADCY7/GNG5/GNGT2/PER2/RPS6KA5/CAMK2G/CALM1/CALM3/GNAI2/ADCY3/PLCB1/PLCB3/GNG10/ADCY6	-1.35208644402792
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	27/2395	134/9376	0.788807528121397	PRKACB/ARHGEF12/ARHGEF1/MAPK1/PPP1CB/ITPR1/PPP1CC/GNA13/MAP2K1/MAP2K2/ADCY7/RAF1/PPP1R12A/BRAF/PRKCH/CALM1/CALM3/ROCK1/PLA2G6/ADCY3/RHOA/PRKCD/ARAF/PLCB1/PLCB3/KCNMB4/ADCY6	-1.44220643340454
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/2395	86/9376	0.728339078506579	PRKACB/CAMK2D/ADCY7/ATF2/ATP1A1/ATF6B/ATP1B1/VAMP2/CAMK2G/ADCY3/PLCB1/PLCB3/KCNMB4/RAB3A/ADCY6/STX1A	-1.48234098398521
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/2395	17/9376	0.460567358467395	CSAD/ADO	-1.30384671626643
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/2395	49/9376	0.639154701546589	PRKACB/GNAI3/NFKB1/ATF2/ATF6B/RGS9/GNAI2/CDK5	-1.48329550570247
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2395	29/9376	0.539975523720394	RGS9/CALM1/CALM3/GUCY2D	-1.45319332805816
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/2395	24/9376	0.489352818371607	HS6ST2/XYLT1/HS2ST1	-1.46708031257925
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/2395	89/9376	0.703788323051301	PRKACB/GLS/SLC38A1/GNAI3/ADCY7/GNG5/GNGT2/NSF/GABARAPL2/SLC38A2/GNAI2/ADCY3/GNG10/ADCY6/GABRD/GPHN	-1.64451952242991
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/2395	66/9376	0.652470424495477	IL18/STAT4/GATA3/IFNGR1/NFKB1/STAT1/STAT3/TBX21/IL4R/NOD2/IL2RG	-1.65946644495556
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/2395	76/9376	0.669640698824305	HMGCS1/SLC27A2/SCP2/ACADM/ACSL3/DBI/RXRA/SLC27A5/FABP5/ACSL5/PPARD/GK/SCD5	-1.6936803102262
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/2395	52/9376	0.602280391841979	PRKACB/ADCY7/HSD17B7/ACOT4/ADCY3/ACOT2/ADCY6/CYP2J2	-1.68444610631823
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/2395	63/9376	0.621400404281406	GADD45A/LEF1/CTNNB1/BAK1/DDB2/BAX/GSK3B/TP53/TCF7/WNT11	-1.76597762681088
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/2395	93/9376	0.673517857543718	PRKACB/CD38/ITPR1/ADCY7/ATP1A1/ATP1B1/VAMP2/PRH1/CALM1/CALM3/ADCY3/SLC12A2/PLCB1/ADRB1/PLCB3/ADCY6	-1.85325981495286
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/2395	65/9376	0.602280391841979	PRKACB/ITPR1/ADCY7/ATF2/ATF6B/ADCY3/POMC/PLCB1/PLCB3/ADCY6	-1.88458224805281
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/2395	61/9376	0.577596769225504	SLC30A1/TRPM7/ATP1A1/ATP7A/ATP1B1/CLCN2/VDR/SLC26A6/MT1F	-1.93856468648081
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/2395	51/9376	0.537328584878628	AGPS/PAFAH1B1/LPCAT4/SELENOI/PLA2G6/CEPT1/PLB1	-1.94049672682637
Cellular Processes	Cell motility	hsa04814	Motor proteins	37/2395	194/9376	0.746641413597917	KIF2A/MYO1E/DYNLT1/DYNLT3/CAPZA1/CAPZA2/TUBA4A/HOOK3/ACTR10/MYL12A/KIF18A/DYNLL1/MYL12B/TUBE1/KIF3A/STARD9/KIF13B/DCTN6/MYO1D/CENPE/KIF21B/MYO7A/TPM3/DNAH14/TUBA1B/KIFC1/TPM4/KIF20B/KIF2C/MYO19/DNAL4/KIF11/KIF14/KIF9/KIF26B/KIF23/KIF1A	-2.08856225985819
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	20/2395	116/9376	0.674969404650493	PRKACB/GLS/SLC38A1/GNAI3/PPP3CA/MAPK1/PPP3CC/ITPR1/ADCY7/GNG5/GNGT2/GRK2/PPP3R1/SLC38A2/GNAI2/ADCY3/PLCB1/PLCB3/GNG10/ADCY6	-2.06313346072392
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	44/2395	226/9376	0.762177841003566	PRKACB/PTGER2/RRAS2/RAC2/GNAI3/CAMK2D/ATP2A2/MAPK1/RAP1A/PPP1CB/EP300/PPP1CC/VAV3/PTGER3/MAP2K1/MAP2K2/NFKB1/ADCY7/RAF1/ATP1A1/PIK3CA/ATP1B1/PPP1R12A/BRAF/MAPK9/PIK3CD/VAV1/CAMK2G/CAMK4/CALM1/CALM3/ROCK1/AKT1/TIAM1/GNAI2/MAPK8/ADCY3/POMC/RHOA/ADRB1/GIPR/ADCY6/PIK3R1/LIPE	-2.11970570176119
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/2395	79/9376	0.594656589413599	ATP6V1G1/TCIRG1/NSF/ATP6V1D/ATP6V1H/STX3/VAMP2/STX2/ATP6V0E2/RAB3A/ATP6V1E2/STX1A	-2.1190676698345
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/2395	53/9376	0.517052034505849	PRKACB/ATP1A1/ATP1B1/PLCB1/PLCB3/VDR/ADCY6	-2.06509488798445
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2395	30/9376	0.391482254697286	PLA2G6/PLB1/CYP2J2	-1.95524221117759
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2395	16/9376	0.244676409185804	GOT1	-1.77106578942721
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	65/2395	323/9376	0.787812586852124	SOCS1/PIM1/MDM2/CASP3/GLS/BCL2L11/SPRY2/ABCB1/KRAS/RASSF1/SOS2/DDIT4/CCND2/MAPK1/EP300/HDAC1/ATM/BCL2/CCNG1/SIRT1/MAP2K1/MAP2K2/NFKB1/HNRNPK/PDCD4/MCL1/CDKN1B/STAT3/DNMT1/RAF1/CDKN2A/EZH2/PTEN/MDM4/NOTCH2/PIK3CA/UBE2I/GRB2/BAK1/NRAS/SOS1/DNMT3A/RPS6KA5/PIK3CD/CRKL/ROCK1/MTOR/TP53/CDK6/IKBKB/SLC7A1/NOTCH1/ABCC1/EFNA5/HDAC5/RHOA/BRCA1/CD44/STMN1/DNMT3B/BCL2L2/CDCA5/PIK3R1/KIF23/CDC25C	-2.2730249208831
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/2395	54/9376	0.507476996829815	GZMB/PRF1/HLA-F/HLA-B/FASLG/HLA-A/FAS	-2.12592739140163
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/2395	31/9376	0.378853794868341	ALDH3A2/GUSB/ALDH9A1	-2.02891852926337
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/2395	102/9376	0.61408981128986	CD38/ATP2A2/RAB8A/RAP1A/ITPR1/ADCY7/ATP1A1/RAB27B/ATP1B1/ADCY3/SLC12A2/RHOA/PLCB1/PLCB3/TPCN2/ADCY6	-2.29526250950559
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2395	26/9376	0.301140195920989	PLA2G6/PLB1	-2.09002032111495
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	18/2395	115/9376	0.61275483343923	PRKACB/CASP3/GNAI3/KRAS/MAPK1/ITPR1/MAP2K1/GNG5/RAF1/GNGT2/NRAS/BRAF/GNAI2/ARAF/PLCB1/PLCB3/GNG10/CYP2J2	-2.44729071177779
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	26/2395	155/9376	0.656679911105125	CALR/TAP1/SEC22B/TUBA4A/HLA-F/RAB5A/ITGAM/ATP6V1G1/TCIRG1/PIKFYVE/ATP6V1D/ATP6V1H/SEC61B/M6PR/TAP2/HLA-B/STX18/ATP6V0E2/HLA-A/CORO1A/NCF4/SEC61A2/SEC61G/TUBA1B/RILP/ATP6V1E2	-2.52438524142565
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/2395	91/9376	0.559260363853266	PRKACB/GNAI3/ARRB2/ADCY7/GNG5/GNGT2/GRK2/PDE7A/GNAI2/ADCY3/GNG10/ADCY6/GABRD	-2.4745226249522
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/2395	36/9376	0.326235212247738	GUSB/RPE/UGP2	-2.37227865108896
NA	NA	hsa04518	Integrin signaling	25/2395	154/9376	0.635523140742347	ITGAX/ARHGEF6/CCND3/RAC2/ITGB7/ICAM3/CCND2/CTNNB1/CDC42/PARVG/ITGAM/COL9A2/PIK3CA/PXN/PIK3CD/FERMT3/ITGAD/ACTN4/ITGA4/GSK3B/AKT1/MTOR/TLN1/COL9A3/PIK3R1	-2.67114423586948
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/2395	100/9376	0.5480751565762	XCL1/IL18/XCL2/CCR1/IL10RA/IL2RB/CSF1/CCL28/CXCR3/TNFSF14/IL2RA/TNFRSF10A/IL2RG/TNFRSF10B	-2.66112591506229
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/2395	100/9376	0.5480751565762	CD38/CD3E/CD2/CD55/ITGAM/CSF1/CD7/CD37/IL2RA/ITGA4/IL4R/CD44/CD8A/KIT	-2.66112591506229
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/2395	63/9376	0.434980282996984	PTGES3/PTGIS/LTC4S/LTA4H/PLA2G6/PLB1/CYP2J2	-2.63553419025835
NA	NA	hsa03272	Virion - Hepatitis viruses	4/2395	48/9376	0.326235212247738	PDCD6IP/CHMP4A/CHMP7/OCLN	-2.74103283633878
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	31/2395	195/9376	0.622356404903378	RAC2/CASP1/SYK/CASP4/MAPK1/VDAC2/VDAC3/HDAC1/MAP2K1/MAP2K2/NFKB1/HAT1/ITGAM/VDAC1/RAF1/HDAC3/PIK3CA/SLC25A5/HDAC8/PIK3CD/HMGB1/AKT1/NCF4/MTOR/HDAC10/HDAC5/PLCB1/MAP3K7/PLCB3/HDAC6/PIK3R1	-3.12128922716719
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/2395	103/9376	0.494103816608225	PRKACB/CASP3/SERPINB9/RAB5A/NFKB1/ITGAM/PIK3CA/PIK3CD/ACTN4/ARG2/PLCB1/PLCB3/PIK3R1	-3.02377494066281
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/2395	50/9376	0.313185803757829	IL18/KLRB1/MYD88/KLRK1	-2.85204345279705
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/2395	191/9376	0.614893593765371	PRKACB/GNAI3/KRAS/SOS2/MAPK1/PPP1CB/PPP1CC/HDAC1/MAP2K1/HAT1/GNG5/ATF2/RAF1/GNGT2/ATF6B/HDAC3/GRB2/NRAS/SOS1/BRAF/HDAC8/CAMK4/CALM1/CALM3/GNAI2/HDAC10/HDAC5/ARAF/HDAC6/GNG10	-3.14946962770841
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/2395	37/9376	0.211612029566101	GOT1/FAH	-2.81429903268152
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/2395	90/9376	0.434980282996984	PRKACB/ABCB1/ADCY7/ATP1A1/ATP1B1/HMGCR/RXRA/SLC27A5/ADCY3/ADCY6	-3.1546421112461
Human Diseases	Immune disease	hsa05310	Asthma	1/2395	32/9376	0.122338204592902	FCER1G	-2.91283139122619
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/2395	50/9376	0.234889352818372	ITGB7/CCL28/ITGA4	-3.1771748806285
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/2395	254/9376	0.616507487712261	PRKACB/CD38/CYSLTR1/CAMK2D/CAMK1/ATP2A2/PPP3CA/PPP3CC/VDAC2/VDAC3/ITPR1/PTGER3/STIM1/ADCY7/VDAC1/PTK2B/ORAI2/ORAI3/SLC25A5/PHKG2/PPP3R1/STIM2/CAMK2G/NFATC3/CAMK4/ASPH/CALM1/CALM3/PTGER1/ADCY3/NFATC2/PLCB1/SPHK2/ADRB1/PLCB3/TPCN2/PHKA2/FGF22/P2RX4/TFEB	-3.6291781808719
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/2395	43/9376	0.182084769626645	ACAT2/AGPAT2	-3.14855633464369
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/2395	105/9376	0.410124266825728	PRKACB/ITGB7/ATP2A2/ADCY7/SNTB1/ITGA4/ADCY3/TPM3/TPM4/ADRB1/ADCY6	-3.56017599210694
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/2395	68/9376	0.287854599042122	CYP26A1/RDH11/DHRS4L2/DHRS4/PNPLA4	-3.45202968015331
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/2395	95/9376	0.370877925502692	IL18/ATP6V1G1/CSF1/TCIRG1/ATP6V1D/ATP6V1H/ATP6V0E2/TNFSF11/ATP6V1E2	-3.60976490461637
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/2395	70/9376	0.279630181926633	GSTM2/GSTK1/NAT1/MGST2/GSTP1	-3.54325641856479
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/2395	86/9376	0.318648346846628	PRKACB/P2RY1/PLCB1/PLCB3/TAS2R14/TAS2R30/ADCY6	-3.71785339762155
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/2395	86/9376	0.318648346846628	LEF1/ITGB7/ATP2A2/CTNNB1/SNTB1/ITGA4/TCF7	-3.71785339762155
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2395	41/9376	0.0954834767554356	GABRD	-3.39962371428623
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/2395	160/9376	0.464885177453027	NCAM1/ITGB7/ICAM3/CD58/CD2/PTPRC/HLA-F/ITGAM/SPN/HLA-B/HLA-A/ITGA4/NECTIN1/NECTIN3/CD99/CD226/CD8A/LRRC4/OCLN	-3.99866772533826
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/2395	103/9376	0.342071873036464	SLC1A5/SLC3A2/ATP1A1/COL9A2/ATP1B1/SLC38A2/COL24A1/SLC36A4/COL9A3	-3.93247992054709
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/2395	99/9376	0.31634929672508	ITGB7/ATP2A2/SNTB1/PRKAG1/ITGA4/TPM3/TPM4/PRKAB1	-4.00523185838578
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/2395	79/9376	0.247773578922333	GSTM2/GSTK1/AKR7A2/MGST2/GSTP1	-3.93251412917992
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/2395	73/9376	0.214510824491664	GSTM2/GSTK1/MGST2/GSTP1	-3.94611467905824
NA	NA	hsa04519	Cadherin signaling	65/2395	404/9376	0.629860063250584	LEF1/RRAS2/KRT81/ARPC5L/MYO1E/RAC2/ACTR3/KRAS/MOB1A/EVL/CTNNB1/MAPK1/CSNK1A1/ACTR2/TMC8/PPP1CB/SHOC2/EP300/MAP2K3/PPP1CC/VASP/CDC42/VAV3/ARPC1B/KRT86/MAP2K1/MAP2K2/NFKB1/TMC6/ARPC3/ADAM10/PTK2B/RAF1/ABI2/YWHAZ/NCKAP1L/RYK/CYFIP2/NRAS/MAPK9/LATS1/VAV1/BRK1/ACTN4/ROCK1/GSK3B/CHUK/ARPC4/MYO1D/TCF7/MAPK8/ARPC5/IKBKB/MOB1B/MRAS/MYO7A/ARPC2/RHOA/PSEN2/YWHAB/LIMD1/WASF1/ACTR3C/WNT11/GABRD	-4.45442421589389
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/2395	66/9376	0.177946479407857	HSD17B7/HSD17B11/SRD5A1	-3.92533565351904
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/2395	89/9376	0.263920621144238	CD47/ITGB7/COL9A2/ITGA4/CD44/COL9A3	-4.08659415812304
NA	NA	hsa04081	Hormone signaling	27/2395	219/9376	0.482649355106243	PRKACB/GNAI3/GNA13/ADCY7/STAT3/GNG5/SMAD4/GNGT2/PIK3CA/APPL1/SMAD5/PIK3CD/JAK2/GNAI2/ADCY3/STK11/POMC/RHOA/PLCB1/GNRH1/ADRB1/PLCB3/BMPR1A/GNG10/GIPR/ADCY6/PIK3R1	-4.53743088859741
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/2395	233/9376	0.453648964670675	ITGB7/TMOD3/CAPZA1/LBR/CAPZA2/SPTAN1/FMNL3/ATP1A1/COL9A2/LMNB1/ATP1B1/DIAPH1/COL24A1/SNTB1/TMEM43/FMNL1/ITGA4/AMPD2/ANK2/ENO1/TPM3/TLN1/TPM4/LMOD3/COL9A3/DIAPH3/NEB	-4.94635120311764
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/2395	88/9376	0.177946479407857	ITGAX/CD55/ITGAM/CD46	-4.53795206859512
NA	NA	hsa04082	Neuroactive ligand signaling	19/2395	199/9376	0.373777027097911	PRKACB/GNAI3/ADCY7/GNG5/GNGT2/OGFR/OGFRL1/P2RY1/GNAI2/ADCY3/POMC/PLCB1/ADRB1/PLCB3/GNG10/P2RX4/ADCY6/GABRD/SLC17A9	-5.22979596952323
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/2395	298/9376	0.407246640792479	XCL1/IL18/TNFRSF18/XCL2/CCR1/IL10RA/IFNGR1/IL2RB/TNFRSF4/CSF1/OSM/IL27RA/IL16/CCL28/CXCR3/TNFSF14/FASLG/RELT/IL2RA/IL4R/TNFRSF10A/IL2RG/GDF11/TNFSF11/TNFRSF10B/FAS/TNFSF4/ACVR1B/BMPR1A/IFNL1/IL32	-6.09069209160045
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/2395	143/9376	0.164258288684176	SSB/SNRPD3/SNRPD1/SNRPB/ACTN4/TRIM21	-5.89859063651404
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/2395	99/9376	0.039543662090635	ITGAM	-5.6269236684105
NA	NA	hsa04382	Cornified envelope formation	15/2395	217/9376	0.270609853477387	KRT81/UGCG/PPP2R5A/KRT86/PPP2R2A/PPP2R2B/ABHD5/PPP2CA/SPTLC1/PPP2R3C/BLMH/CAPN1/PPP2R2D/GBA2/OCLN	-6.36715331713106
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/2395	370/9376	0.275095638435931	PTGER2/CYSLTR1/GZMA/PTGER3/PTGDR/OGFR/S1PR4/PAQR6/OGFRL1/P2RY1/PTGER1/NMUR1/P2RY10/LPAR3/CHRNB1/POMC/GNRH1/ADRB1/CHRNA5/LPAR2/CNR2/RLN2/P2RX4/GIPR/TMEM97/GABRD	-8.33288103420686
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/2395	449/9376	0.104627774083907	PRKACB/NCALD/CAMK2D/ARRB2/GRK2/CAMK2G/CALM1/CALM3/OR2A25/ADCY3/GUCY2D/OR11G2	-11.3881610380836