category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	120/2128	250/9376	2.11488721804511	SLC11A2/SLC11A1/CTSL/SLC2A6/LAMTOR3/ATP6V1C1/SLC36A4/BLOC1S2/ARL8A/M6PR/ARL8B/MCOLN2/DMXL2/CTBS/DMXL1/OSTM1/GGA2/LAMP1/CTSB/VPS26A/VPS13C/IGF2R/NPC1/SPG11/SCARB2/GGA1/ATP6V1B2/MANBA/ATP6V1H/CTSC/AP1G1/FUCA1/SLC15A4/ATP6V0A1/AP1S2/RRAGC/PLEKHM1/NEU1/GLA/ATP6V1D/OSBP/LAPTM5/VPS29/DTNBP1/LGMN/OSBPL3/ATP6V1A/CD164/CTSS/ZFYVE26/ARSB/GALC/VAMP7/AP5B1/SLC36A1/GNPTAB/AP3M1/AP5M1/HEXA/RAB7A/GALNS/PIKFYVE/ABCA5/RRAGD/LIPA/MCOLN1/BLOC1S6/CLN8/MITF/MCOLN3/AP3S1/AP4S1/SLC17A5/NAGA/MFSD8/SLC38A9/VPS33A/VPS39/CTNS/TLR3/MAN2B1/ASAH1/LAMP2/NAGPA/FIG4/OSBPL2/SORT1/ATP6V1G1/ACP2/SNAPIN/VPS13A/TLR8/GM2A/SLC15A3/AKT1S1/CTSH/ARSG/DNASE2/TFEB/GNS/STX17/RRAGB/PPT1/AP4B1/RPTOR/CLTA/MTOR/ATP6V1E2/LITAF/AP1G2/AP3S2/ATP6V0D2/SGSH/CLN3/TELO2/BLOC1S3/VAMP8/ATP6V1F/AP1S3/CTSD	9.68106344269509
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	95/2128	187/9376	2.23834988540871	IL18/TANK/RIPK2/CXCL8/CASP1/IL6/TBK1/NAMPT/NAIP/HSP90AA1/TNF/GBP1/TRPM2/TLR4/NLRP3/TRPM7/IL1B/PRKCD/TNFAIP3/OAS2/AIM2/IRF7/BIRC2/CCL2/OAS1/CTSB/GBP5/CARD8/CHUK/CASP4/TAB2/HSP90AB1/CASP8/IFI16/TRAF3/ATG5/MAPK13/GBP2/STAT2/CXCL1/NFKBIA/ITPR2/MEFV/P2RX7/SUGT1/BCL2L1/MYD88/GBP4/DNM1L/ERBIN/NFKB1/TRAF6/CARD6/MAP3K7/NEK7/RIPK1/CXCL3/IKBKE/IFNAR2/OAS3/IRAK4/XIAP/VDAC1/MAPK1/IRF9/NLRC4/IKBKB/MAP1LC3B/RNASEL/MCU/MAPK9/CASP5/JUN/TAB3/TP53BP1/GBP3/VDAC3/CARD16/TXN/PLCB2/CYBB/NOD2/ITPR1/RIPK3/BCL2/TRAF2/NOD1/TXNIP/ATG16L1/MFN1/PLCB3/CXCL2/BIRC3/NLRP1/RHOA	9.2681361175313
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	103/2128	216/9376	2.1010164299638	HSPA1B/IL18/SOD2/HSPA1A/TANK/HSPA5/VAV3/CXCL8/ABCG1/HSPD1/CASP1/IL6/CCL3L1/TBK1/HSP90AA1/CCL3/TLR2/ABCA1/TNF/DDIT3/TLR4/HSPA6/PPARG/NLRP3/IL1B/CASP7/XBP1/HSPA8/HSPA4/IRF7/CD40/CCL2/IRAK1/CAMK2D/ICAM1/CHUK/RAP1A/NRAS/LY96/TAB2/HSP90AB1/CASP8/CYCS/TRAF3/TNFRSF10B/BID/MAPK13/KRAS/MAP2K3/PPP3R1/CXCL1/EIF2S1/NFKBIA/TNFRSF10A/STAT3/BCL2L1/MYD88/CASP3/ERO1A/NCF2/TLR6/VAV1/NFKB1/NCF4/NCF1/BAX/TRAF6/MAP3K7/FAS/OLR1/CXCL3/IKBKE/LYN/IRAK4/ERN1/MAPK1/AKT1/PPP3CC/GSK3B/EIF2AK3/IKBKB/CDC42/HSP90B1/PRKCA/MAPK9/JUN/PLCB2/CYBB/NFATC1/FOS/ITPR1/CASP9/BCL2/APAF1/CALM1/TRAF2/PLCB3/CXCL2/RAP1B/LDLR/TICAM2/RHOA/NFE2L2	8.87023848086344
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	109/2128	248/9376	1.93651467378123	IL18/RIPK2/CXCL8/CASP1/IL6/NAIP/HSP90AA1/TLR2/TNF/MLKL/ARL8A/TLR4/M6PR/NLRP3/ARL8B/CYTH1/IL1B/CASP7/ABI1/BIRC2/IRAK1/ACTR3/DYNLT1/DNM2/SNX18/CHUK/LY96/CASP4/TAB2/HSP90AB1/CASP8/CYCS/DYNLT3/ACBD3/RAF1/TNFRSF10B/MAPK13/EXOC5/MAP2K3/PLEKHM2/DCTN4/PLEKHM1/NFKBIA/TNFRSF10A/ARF6/RAB5A/MYD88/CASP3/MAP2K1/CYFIP1/TLR6/ELMO2/PIK3C3/KPNA4/NFKB1/RHOB/BAX/TRAF6/PAK1/RAB7A/MAP3K7/ACTR10/RIPK1/EXOC4/PIK3CG/RAB5B/ACTR2/CTNNB1/CYTH4/ELMO1/IRAK4/MAPK1/AKT1/RAB9A/DCTN6/VPS33A/VPS39/NLRC4/IKBKB/CDC42/ARPC1B/KPNA1/HSP90B1/MAPK9/CASP5/JUN/EXOC2/TAB3/TXN/EXOC7/FOS/TUBA1B/ARF1/TLR5/MYL12A/ARPC3/RIPK3/FBXO22/BCL2/RHOH/RALA/PTPRC/TRAF2/NOD1/BIRC3/SKP1/RHOA/DYNLL1/ARPC5	8.09869360733719
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	81/2128	169/9376	2.11175868665747	VMP1/TANK/DAPK1/TBK1/CTSL/C9orf72/HIF1A/RAB8A/PRKCD/STX7/LAMP1/CTSB/WDFY3/ATG4C/NRAS/PTEN/EPG5/ATG5/NRBF2/RAF1/MTMR4/MTMR3/KRAS/EIF2S1/RRAGC/PLEKHM1/SUPT20H/RAB1A/BCL2L1/MAP2K1/PIK3C3/BIRC6/TRAF6/RHEB/SMCR8/PPP2CA/CALCOCO2/RAB7A/MAP3K7/RRAGD/TP53INP2/ATG7/SH3GLB1/ERN1/MAPK1/AKT1/VPS33A/VPS39/EIF2AK3/WIPI1/LAMP2/ATG3/MAP1LC3B/ULK2/MAPK9/TSC1/DDIT4/ATG2B/STK11/RPS6KB1/AKT1S1/ITPR1/STX17/RRAGB/ATG101/SQSTM1/RPTOR/BCL2/MTOR/GORASP1/RUBCN/ATG16L1/AMBRA1/CFLAR/VAMP8/ATG16L2/PIK3R4/ATG4D/DAPK2/UBB/CTSD	7.90236653877386
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	38/2128	56/9376	2.98979591836735	HSPA1B/IL18/HSPA1A/CXCL8/HSPD1/CASP1/IL6/NAIP/SEC22B/TLR2/TNF/TLR4/HSPA6/IL1B/CASP7/HSPA8/CASP8/CYCS/CLK1/CXCL1/CR1/RAB1A/NFKBIA/MYD88/CASP3/NFKB1/ITGAM/BCL2L13/NFKB2/SAR1B/CXCL3/NLRC4/CLK4/ARF1/TLR5/CASP9/APAF1/CXCL2	8.09202005931682
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	84/2128	181/9376	2.04478045943588	IL18/RIPK2/HSPD1/IL6/FCGR2A/TLR2/TLR1/TNF/IFNGR1/IRAK2/HLA-DQB1/TLR4/FCGR2B/IFNGR2/PLK3/HSPA9/IL1B/CLEC7A/FCGR3A/CLEC4E/BCL10/LAMP1/FCGR1A/IRAK1/CAMK2D/IL10/IL10RA/CEBPB/CEBPG/IL1A/CASP8/CYCS/ATP6V1H/RAF1/BID/MAPK13/PPP3R1/ATP6V0A1/CR1/RAB5A/MYD88/CASP3/HLA-DQA1/ITGAX/CTSS/TLR6/PIK3C3/RFX5/NFKB1/IL10RB/BAX/TRAF6/FCER1G/CASP10/ITGAM/RAB7A/RAB5B/NFYC/NFYA/IRAK4/MAPK1/AKT1/PPP3CC/EP300/LAMP2/VDR/MAPK9/CIITA/CD209/MALT1/MRC1/NOD2/IL23A/CASP9/BCL2/APAF1/CALM1/ATP6V0D2/HLA-DQA2/SPHK2/CYP27B1/RHOA/FCGR3B/CTSD	7.6904334749548
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	80/2128	174/9376	2.0257540402731	HSPA1B/HSPH1/HSPA1A/HSPA5/DNAJB11/UBE2D1/HSP90AA1/HYOU1/DDIT3/DNAJA1/HERPUD1/CALR/HSPA6/XBP1/DNAJB1/ERO1B/HSPA8/SEC23B/PDIA4/EDEM1/SYVN1/SEC24A/HSP90AB1/EDEM3/MAN1A1/EIF2S1/SEC24D/UBQLN2/STT3B/UBE2G1/UBE2J1/UBQLN1/RAD23B/ERO1A/CUL1/DERL2/SEL1L/DNAJA2/OSTC/EDEM2/BAX/UFD1/NGLY1/UBE2G2/MBTPS1/DNAJC3/RPN1/TRAM1/SEC23A/SAR1B/UBE2D3/ATF6B/FBXO6/ERN1/RAD23A/NPLOC4/UGGT1/EIF2AK3/CANX/UBE4B/PPP1R15A/HSP90B1/MAPK9/PDIA6/SEC24C/OS9/RNF5/SEC61B/SEC24B/MOGS/YOD1/UBE2D4/PDIA3/BCL2/MAN1C1/TRAF2/HSPA4L/UBXN8/SKP1/NFE2L2	7.40012581593073
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	80/2128	180/9376	1.95822890559733	IL6/TBK1/TLR2/TNF/SRSF7/IFNGR1/HLA-DQB1/CALR/CGAS/IFNGR2/IL1B/NXF1/OAS2/IRF7/ZC3HAV1/BIRC2/CCL2/OAS1/IRAK1/SRSF1/SRSF6/CHUK/TAB2/CASP8/CYCS/TRAF3/SRSF5/BID/HLA-F/STAT2/SRSF2/SOCS3/EIF2S1/NFKBIA/TAP1/BCL2L1/MYD88/CASP3/HLA-DQA1/SRSF3/IFIH1/NFKB1/PPP1CB/BAX/PPP1CC/TRAF6/RHEB/SP100/SRSF9/MAP3K7/PILRA/FAS/IKBKE/IFNAR2/OAS3/TNFRSF14/IRAK4/AKT1/IRF9/TLR3/SRSF4/IKBKB/EIF2AK2/RNASEL/TSC1/TAP2/PILRB/EIF2B1/EIF2B3/PDIA3/CASP9/BST2/BCL2/MTOR/APAF1/TRAF2/HLA-DQA2/B2M/SRSF8/BIRC3	7.03344986994849
Human Diseases	Infectious disease: viral	hsa05162	Measles	65/2128	136/9376	2.10581601061477	HSPA1B/HSPA1A/IL6/TBK1/IL2RA/TLR2/TLR4/MX1/FCGR2B/HSPA6/IL1B/TNFAIP3/HSPA8/OAS2/IRF7/OAS1/IRAK1/CHUK/CCND1/TAB2/IL1A/CASP8/CYCS/TRAF3/BID/STAT2/EIF2S1/NFKBIA/STAT3/JAK3/BCL2L1/MYD88/CASP3/IFIH1/NFKB1/BAX/STAT5A/TRAF6/MAP3K7/FAS/IKBKE/CDKN1B/IFNAR2/OAS3/ADAR/IRAK4/AKT1/RAB9A/IRF9/GSK3B/BBC3/IKBKB/RCHY1/EIF2AK2/MAPK9/MX2/JUN/CD209/FOS/MSN/CASP9/BCL2/APAF1/SLAMF1/CDK2	7.03847706601138
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	59/2128	119/9376	2.18449485057181	ADAM17/IL6/CCL20/TNF/MAP3K8/MLKL/IL1B/CASP7/TNFAIP3/ATF2/BIRC2/CCL2/TRAF1/ICAM1/CEBPB/CHUK/TAB2/CASP8/TRAF3/CYLD/MAPK13/MAP2K3/SOCS3/CXCL1/NFKBIA/CASP3/PTGS2/MAP2K1/DNM1L/BAG4/NFKB1/IRF1/CASP10/MAP3K7/RIPK1/FAS/CXCL3/CSF1/ATF6B/XIAP/MAPK1/AKT1/IKBKB/PGAM5/MAPK9/JUN/TAB3/CXCL10/FOS/NOD2/CREB5/MMP14/RIPK3/TRAF2/LIF/CFLAR/CXCL2/BIRC3/JAG1	7.04585795516878
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	54/2128	105/9376	2.26595059076262	PLAU/CXCL8/BCL2A1/TNF/TLR4/TRIM25/IL1B/TNFAIP3/CD40/BIRC2/BCL10/IRAK1/TRAF1/ICAM1/CHUK/LY96/TAB2/CCL4L2/BTK/TRAF3/CYLD/CXCL1/NFKBIA/BCL2L1/MYD88/PTGS2/LTBR/BLNK/NFKB1/ERC1/TRAF6/ATM/MAP3K7/RIPK1/NFKB2/CXCL3/GADD45A/LYN/IRAK4/CCL4/XIAP/IKBKB/TNFSF13B/TAB3/PIAS4/MALT1/CXCL12/BCL2/TRAF2/CFLAR/CXCL2/BIRC3/TICAM2/GADD45B	7.06822673612317
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	75/2128	173/9376	1.91012212612456	IL18/CXCL8/CASP1/IL6/TBK1/TNF/IFNGR1/HLA-DQB1/TLR4/MX1/IFNGR2/RSAD2/NLRP3/TRIM25/IL1B/NXF1/DNAJB1/OAS2/IRF7/PABPN1/CCL2/OAS1/ICAM1/CHUK/XPO1/IL1A/CASP8/CYCS/TRAF3/NUP98/RAF1/TNFRSF10B/BID/STAT2/SOCS3/EIF2S1/NFKBIA/TNFRSF10A/MYD88/CASP3/MAP2K1/HLA-DQA1/IFIH1/NFKB1/BAX/CALCOCO2/DNAJC3/FAS/NXT2/IKBKE/IFNAR2/OAS3/ADAR/IRAK4/VDAC1/MAPK1/AKT1/IRF9/SLC25A5/TLR3/EP300/IKBKB/EIF2AK2/RNASEL/KPNA1/PRKCA/MX2/CXCL10/CIITA/KPNA2/NXT1/CASP9/KPNA5/APAF1/HLA-DQA2	6.54666881015394
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	64/2128	142/9376	1.98580959440856	UBE2D1/HERC4/SMURF2/SIAH1/UBE2A/MDM2/UBE2F/BIRC2/UBA6/MAP3K1/NEDD4L/UBE2W/SYVN1/UBE2N/VHL/PIAS1/KLHL9/SOCS3/UBE2B/UBE2G1/UBE2J1/SOCS1/CUL2/UBE2Z/CUL1/TRIP12/UBE3A/BIRC6/UBE2E1/TRAF6/HERC2/UBE2G2/CDC27/ELOC/CUL3/PIAS2/ANAPC10/UBE2D3/CUL4A/UBE2Q1/UBE4A/ANAPC7/CUL5/UBA2/XIAP/CDC26/PPIL2/UBR5/COP1/RCHY1/UBE4B/PIAS4/UBE3B/CDC23/ANAPC4/HERC1/FANCL/UBE2D4/ERCC8/SMURF1/BIRC3/ANAPC1/SKP1/UBB	6.4136408301507
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	52/2128	108/9376	2.12141464773044	DDX39B/ACIN1/NUP58/NXF1/TMEM33/XPO1/NUP62/NUP98/EIF4A3/THOC1/NUP54/TNPO1/IPO7/KPNA4/SUMO1/RNPS1/AHCTF1/NUP153/THOC3/POM121C/NXT2/NMD3/NUP205/PYM1/NCBP2/XPO4/KPNA1/NUP107/NUP160/SEH1L/SUMO4/RAN/KPNA2/RANBP2/NCBP1/NXT1/DDX19A/NUP133/THOC6/XPOT/NUP88/NUP93/NUP43/SENP2/KPNA5/NUP155/XPO5/XPO7/SUMO2/IPO11/NUP35/NUP188	6.35107801222027
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	70/2128	163/9376	1.89215369712625	CXCL8/IL6/TBK1/TLR2/TNF/RB1/TLR4/IRF7/ATF2/GRB2/MAP3K1/IRAK1/CHUK/NRAS/TAB2/CASP8/CYCS/TRAF3/RAF1/BID/MAPK13/KRAS/MAP2K3/STAT2/DDX3X/NFKBIA/STAT3/JAK3/MYD88/CASP3/MAP2K1/SMAD4/PCNA/IFIH1/NFKB1/STAT6/BAX/STAT5A/EGR2/E2F3/TRAF6/CASP10/TGFBR2/SOS2/MAP3K7/SOS1/FAS/IKBKE/ATF6B/IRAK4/BRAF/MAPK1/AKT1/TLR3/EP300/IKBKB/PRKCA/MAPK9/JUN/VDAC3/EGR3/NFATC1/FOS/CREB5/CDKN1A/CASP9/BCL2/APAF1/TICAM2/CDK2	6.22580198875756
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	80/2128	196/9376	1.79837348473224	CXCL8/IL6/TBK1/IFNGR1/HIF1A/RB1/ZFP36/CCR1/IRF7/HCK/PREX1/ICAM1/GNB4/PDGFB/CHUK/NRAS/CCND1/CASP8/CYCS/TRAF3/RAF1/BID/HLA-F/MAPK13/GNG10/KRAS/PPP3R1/STAT2/CXCL1/NFKBIA/STAT3/ITPR2/CASP3/PTGS2/MAP2K1/PIK3C3/MICB/NFKB1/BAX/E2F3/FAS/PIK3CG/CXCL3/IKBKE/CTNNB1/CCR5/PIK3R5/IFNAR2/LYN/MAPK1/AKT1/PPP3CC/IRF9/GSK3B/TLR3/EP300/ATG3/IKBKB/MAP1LC3B/EIF2AK2/CLEC2B/MAPK9/JUN/GNG5/CD200R1/GNGT2/RCAN1/NFATC1/FOS/ITPR1/CD86/CDKN1A/CASP9/MTOR/CALM1/TRAF2/MICA/CXCL2/PIK3R6/UBB	6.12033448568595
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	61/2128	137/9376	1.961802316009	PMAIP1/BCL2A1/CTSL/TNF/DDIT3/CASP7/BIRC2/MCL1/TRAF1/CTSB/CHUK/NRAS/CASP8/CYCS/RAF1/TNFRSF10B/BID/CTSC/KRAS/EIF2S1/NFKBIA/TNFRSF10A/ITPR2/BCL2L1/CASP3/MAP2K1/CTSS/NFKB1/PARP4/BAX/CASP10/ATM/RIPK1/FAS/AIFM1/GADD45A/XIAP/ERN1/MAPK1/AKT1/BBC3/EIF2AK3/IKBKB/MAPK9/JUN/SPTAN1/FOS/TUBA1B/ITPR1/CTSH/CASP9/BCL2/APAF1/TRAF2/CFLAR/HTRA2/BIRC3/IL3RA/GADD45B/LMNB1/CTSD	6.14463338611707
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	82/2128	205/9376	1.76240601503759	IL6/TBK1/TLR2/TNF/HLA-DQB1/CALR/RB1/PSMD11/NFKBIE/TNFAIP3/OAS2/IRF7/MDM2/CD40/SAP30/OAS1/IRAK1/ICAM1/CHUK/CCND1/TAB2/CASP8/CYCS/POLK/BTK/ENTPD1/TRAF3/PSMC6/BID/HLA-F/MAPK13/MAP2K3/STAT2/NFKBIA/CD58/STAT3/JAK3/PSMD12/TAP1/MYD88/CASP3/HLA-DQA1/CD44/PSMC2/BLNK/NFKB1/BAX/E2F3/TRAF6/MAP3K7/PSMC4/RIPK1/NFKB2/FAS/USP7/IKBKE/CDKN1B/GADD45A/IFNAR2/OAS3/LYN/IRAK4/PSMD6/AKT1/SIN3A/IRF9/IKBKB/EIF2AK2/MAPK9/JUN/CXCL10/TAP2/PDIA3/CDKN1A/CASP9/BCL2/APAF1/TRAF2/HLA-DQA2/B2M/GADD45B/CDK2	5.98022130028079
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	96/2128	253/9376	1.67184760319772	IL18/RIPK2/CXCL8/CASP1/TBK1/UBE2D1/NAIP/TNF/PPID/TLR4/CGAS/NLRP3/HK2/CYTH1/IL1B/PRKCD/MDM2/BCL10/HK3/ACTR3/ARHGEF2/CHUK/UBE2N/CASP4/TAB2/CYCS/ATG5/MAPK13/RRAGC/NFKBIA/ARF6/ITPR2/BCL2L1/MYD88/CD44/CUL1/ELMO2/PIK3C3/NFKB1/BAX/TRAF6/HCLS1/CALCOCO2/ATM/MAP3K7/RRAGD/RIPK1/UBE2D3/ACTR2/CYTH4/ELMO1/VDAC1/MAPK1/AKT1/GSK3B/TNIP1/NLRC4/WIPI1/ACTN1/IKBKB/CDC42/MAP1LC3B/ARPC1B/DIAPH1/MAPK9/JUN/TAB3/TIFA/FNBP1/PLCB2/MALT1/RPS6KB1/TECPR1/FOXO3/AKT1S1/ITPR1/UBE2D4/RRAGB/ARF1/TLR5/MYL12A/ARPC3/SQSTM1/RPTOR/BCL2/MTOR/TRAF2/NOD1/ATG16L1/PLCB3/GLMN/PIK3R4/SKP1/RHOA/UBB/ARPC5	5.86981688237285
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	52/2128	112/9376	2.04564983888292	HSPA1B/HSPA1A/TLR2/TNF/IFNGR1/HLA-DQB1/TLR4/HSPA6/IFNGR2/HSPA8/CD40/BIRC2/IRAK1/IL10/IL10RA/CHUK/LY96/TAB2/CASP8/CYCS/GNAI3/ALOX5/MAPK13/MAP2K3/NFKBIA/STAT3/SOCS1/BCL2L1/MYD88/CASP3/HLA-DQA1/NFKB1/IL10RB/TRAF6/MAP3K7/PIK3CG/CCR5/PIK3R5/IRAK4/XIAP/MAPK1/AKT1/PPIF/IKBKB/MAPK9/CIITA/CASP9/BCL2/HLA-DQA2/BIRC3/LDLR/PIK3R6	6.03195885803595
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	66/2128	156/9376	1.86408328513592	TBK1/TNF/IFIT1/RB1/MX1/NR1H3/RSAD2/OAS2/IRF7/GRB2/OAS1/CHUK/NRAS/CCND1/CASP8/CYCS/PIAS1/TRAF3/RAF1/BID/KRAS/STAT2/SOCS3/PPP2R2A/EIF2S1/NFKBIA/STAT3/CASP3/MAP2K1/YWHAG/NFKB1/BAX/E2F3/TRAF6/PPP2CA/SOS2/YWHAH/RIPK1/SOS1/FAS/IKBKE/CTNNB1/IFNAR2/OAS3/BRAF/MAPK1/AKT1/IRF9/GSK3B/TLR3/PPP2R2D/IKBKB/EIF2AK2/RNASEL/MX2/CXCL10/CLDN23/CDKN1A/CASP9/APAF1/TRAF2/OCLN/CFLAR/LDLR/CDK2/CLDN15	5.89677830721429
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	66/2128	157/9376	1.85221014319238	NBN/CXCL8/IL6/PPID/RB1/TRPM7/MDM2/ZFP36L1/NRAS/CCND1/HIPK1/IL1A/PTEN/RAF1/HLA-F/MAPK13/KRAS/MAP2K3/PPP3R1/SIRT1/ITPR2/MAP2K1/HIPK3/NFKB1/PPP1CB/E2F4/HUS1/E2F3/PPP1CC/RHEB/RBBP4/ATR/TGFBR2/ATM/TRPV4/LIN54/GADD45A/RAD9A/VDAC1/MAPK1/AKT1/PPP3CC/SLC25A5/RBL2/MRE11/CDKN2B/MCU/TSC1/VDAC3/NFATC1/RAD50/FOXO3/ITPR1/CDKN1A/SQSTM1/MTOR/CDKN2A/CALM1/ZFP36L2/LIN9/GADD45B/RBL1/CDK2/RAD1/CHEK1/LIN52	5.83467909957444
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	61/2128	142/9376	1.89272476967066	ATP2A2/FCGR2A/TNF/IFNGR1/LILRB1/LCP2/FCGR2B/PPARG/IFNGR2/SIRPA/IL1B/FCGR3A/GRB2/LILRB4/FCGR1A/CHUK/TAB2/IL1A/BTK/OSCAR/CYLD/MAPK13/PPP3R1/STAT2/SOCS3/NFKBIA/ITPR2/SOCS1/MAP2K1/LILRA5/NCF2/BLNK/NFKB1/NCF4/NCF1/TRAF6/TGFBR2/MAP3K7/LILRA1/NFKB2/CSF1/MITF/IFNAR2/MAPK1/AKT1/PPP3CC/IRF9/LILRB5/IKBKB/MAPK9/JUN/LILRB3/NFATC1/TEC1/FOS/FOSL1/ITPR1/SQSTM1/TRAF2/FCGR3B/JUND	5.80803439662374
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	66/2128	158/9376	1.84048729418483	FNIP2/SGK1/TNF/LAMTOR3/ATP6V1C1/FNIP1/GRB2/EIF4E/CHUK/NRAS/ATP6V1B2/PTEN/ATP6V1H/RAF1/KRAS/RRAGC/SESN2/RICTOR/ATP6V1D/MAP2K1/ATP6V1A/FZD5/CAB39/FLCN/RHEB/SOS2/FZD2/RRAGD/SOS1/SLC3A2/DVL3/RPS6KA1/LPIN2/BRAF/MAPK1/AKT1/MIOS/SLC38A9/GSK3B/IKBKB/MAPKAP1/ULK2/PRKCA/CLIP1/SEH1L/TSC1/ATP6V1G1/PRR5L/DDIT4/STK11/TBC1D7/RPS6KB1/STRADB/SLC7A5/AKT1S1/RRAGB/RPTOR/MTOR/ATP6V1E2/STRADA/TELO2/LPIN3/DEPDC5/CASTOR2/ATP6V1F/RHOA	5.77302850346785
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	45/2128	94/9376	2.10926251799712	CXCL8/IL6/TBK1/CCL20/HSP90AA1/TNF/IL1B/TNFAIP3/CCL2/SRSF1/CEBPB/CHUK/TAB2/HSP90AB1/CASP8/TRAF3/S100A8/MAPK13/CXCL1/NFKBIA/CASP3/PTGS2/NFKB1/TRAF6/ELAVL1/MAP3K7/CXCL3/IKBKE/MAPK6/MAPK1/GSK3B/IL17RA/IKBKB/HSP90B1/MAPK9/JUN/TAB3/CXCL10/CCL7/FOS/FOSL1/TRAF2/CXCL2/JUND/S100A9	5.85652283341632
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	83/2128	214/9376	1.70887499121636	TBK1/TLR2/TNF/CALR/TLR4/CGAS/IRAK1/APOBEC3G/GNB4/CHUK/NRAS/TAB2/CASP8/CYCS/GNAI3/RAF1/BID/HLA-F/AP1G1/MAPK13/GNG10/KRAS/MAP2K3/PPP3R1/TRIM5/AP1S2/NFKBIA/ITPR2/TAP1/LIMK2/BCL2L1/MYD88/CASP3/MAP2K1/CUL1/NFKB1/BAX/TRAF6/ATR/ATM/PAK1/MAP3K7/RIPK1/FAS/ELOC/CUL4A/CUL5/CCR5/IRAK4/MAPK1/AKT1/PPP3CC/DCAF1/IKBKB/PRKCA/MAPK9/JUN/GNG5/GNAQ/LIMK1/GNGT2/TAP2/NFATC1/FOS/RPS6KB1/ITPR1/PDIA3/CASP9/BST2/APOBEC3F/BCL2/MTOR/AP1G2/CALM1/TRAF2/APOBEC3A/B2M/SKP1/APOBEC3H/SAMHD1/WEE1/CHEK1/AP1S3	5.68386501684816
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	50/2128	109/9376	2.02110781541008	CXCL8/IL6/CCL3L1/TBK1/CD80/CCL3/TLR2/TLR1/TNF/MAP3K8/TLR4/IL1B/IRF7/CD40/IRAK1/CHUK/LY96/TAB2/CASP8/CCL4L2/TRAF3/MAPK13/MAP2K3/STAT2/NFKBIA/IRF5/MYD88/MAP2K1/TLR6/NFKB1/TRAF6/MAP3K7/RIPK1/IKBKE/IFNAR2/IRAK4/CCL4/MAPK1/AKT1/IRF9/TLR3/IKBKB/MAPK9/JUN/CXCL10/TLR8/FOS/CD86/TLR5/TICAM2	5.81001997312168
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	86/2128	227/9376	1.66923917723825	CXCL8/PTGER4/IL6/CCL3L1/TBK1/CCL3/TNF/CALR/RB1/CGAS/IL1B/ARHGEF11/CCR1/MDM2/ATF2/GRB2/CCL2/ITGAV/GNB4/IL10RA/CHUK/ADCY7/NRAS/CCND1/CASP8/CYCS/CCL4L2/GNAI3/RAF1/BID/HLA-F/MAPK13/GNG10/KRAS/PPP3R1/NFKBIA/STAT3/ITPR2/TAP1/SP1/CASP3/PTGS2/MAP2K1/NFKB1/IL10RB/BAX/E2F3/RHEB/SOS2/RIPK1/SOS1/FAS/CTNNB1/ATF6B/CCR5/CCL4/MAPK1/AKT1/PPP3CC/GSK3B/GNA13/IKBKB/PRKCA/PTGER2/GNG5/TSC1/GNAQ/GNGT2/TAP2/PLCB2/NFATC1/IL6R/RPS6KB1/ITPR1/PDIA3/CREB5/CDKN1A/CXCL12/CASP9/MTOR/CDKN2A/CALM1/TRAF2/PLCB3/B2M/RHOA	5.5305691794598
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	92/2128	250/9376	1.62141353383459	HSPA1B/HSPA1A/IL2RA/RAB8A/PDCD6IP/SNX3/HSPA6/SNX1/CYTH1/SMURF2/HSPA8/ZFYVE16/MDM2/RAB10/ARAP1/NEDD4L/ACTR3/VPS26A/DNM2/IGF2R/SPG21/PSD3/SPART/CHMP5/CAPZA2/STAM2/ARFGAP3/EHD4/RUFY1/VPS37A/HLA-F/ARAP2/ARF6/RAB5A/VPS29/ACAP2/SNX2/GIT2/VPS36/CAPZA1/IST1/ARFGEF2/DAB2/RAB35/VPS45/TRAF6/EPS15/TGFBR2/WASHC4/RAB7A/WASHC2A/ASAP1/CHMP2B/WASHC2C/TSG101/SH3GLB1/WASHC5/VTA1/WIPF1/RAB5B/CHMP7/ACTR2/GRK3/CYTH4/SNX4/CCR5/ARRB2/CDC42/ARFGEF1/ARPC1B/SMAP1/EPS15L1/PLD1/SNX5/SMAP2/SNX12/ARF1/MVB12B/ARPC3/AGAP2/RBSN/CLTA/SNX6/LDLRAP1/SMURF1/CAPZB/LDLR/RHOA/AGAP4/TFRC/AGAP5/ARPC5	5.39601113711805
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	47/2128	105/9376	1.97221625492302	CASP1/IL6/TNF/PLK3/NLRP3/IL1B/PRKCD/CLEC7A/CLEC4E/MDM2/BCL10/IL10/CHUK/NRAS/CASP8/CYLD/RAF1/MAPK13/KRAS/PPP3R1/STAT2/NFKBIA/ITPR2/PTGS2/NFKB1/EGR2/IRF1/FCER1G/PAK1/NFKB2/IKBKE/MAPK1/AKT1/PPP3CC/IRF9/IKBKB/MAPK9/JUN/EGR3/CD209/MALT1/NFATC1/ITPR1/IL23A/CALM1/CLEC4D/RHOA	5.42820942340315
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	76/2128	200/9376	1.67428571428571	IL18/CXCL8/CASP1/IL6/FCGR2A/NAIP/TNF/TLR4/NLRP3/CYTH1/IL1B/CASP7/ARHGEF11/ABI1/NCK1/IRAK1/ACTR3/ARHGEF2/CHUK/SEC24A/CASP4/TAB2/CASP8/CYCS/TNFRSF10B/MAPK13/SEC24D/RAB1A/NFKBIA/TNFRSF10A/ARF6/MYD88/CASP3/MYO5A/MYO1E/MYO1G/CYFIP1/LPAR5/NFKB1/BAX/TRAF6/HCLS1/MYO5B/PAK1/MAP3K7/RIPK1/FAS/WIPF1/ACTR2/CYTH4/IRAK4/MAPK1/GNA13/IKBKB/CDC42/NCK2/ARPC1B/MYO1F/MAPK9/JUN/TAB3/SEC24C/SEC24B/CLDN23/FOS/TUBA1B/ARF1/TLR5/CASP9/ARPC3/TRAF2/OCLN/RHOA/LPAR2/CLDN15/ARPC5	5.22269436810233
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	83/2128	224/9376	1.63258592910849	IL6/IL2RA/TNF/HLA-DQB1/CALR/RB1/ZFP36/IL15RA/ATF2/CD40/MAP3K1/ICAM1/CHUK/ADCY7/NRAS/CCND1/XPO1/PTEN/HLA-F/KRAS/PPP3R1/NFKBIA/JAK3/BCL2L1/MAP2K1/HLA-DQA1/SMAD4/VAC14/LTBR/ELK4/NRP1/NFKB1/BAX/STAT5A/EGR2/E2F3/ATR/TGFBR2/ATM/CDC27/NFKB2/POLB/GPS2/ANAPC10/ANAPC7/ATF6B/XIAP/VDAC1/MAPK1/AKT1/PPP3CC/CDC26/SLC25A5/BUB3/EP300/CDKN2B/CANX/IKBKB/ETS2/KAT2B/MAPK9/JUN/EGR1/CRTC3/VDAC3/RAN/TBP/TBPL1/NFATC1/FOS/CRTC2/CDC23/ANAPC4/FOSL1/CREB5/KAT2A/CDKN1A/CDKN2A/HLA-DQA2/B2M/ANAPC1/CDK2/CHEK1	5.19215786616989
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	36/2128	75/9376	2.11488721804511	PMAIP1/SIAH1/STEAP3/MDM2/SESN1/CCND1/MDM4/CASP8/PTEN/CYCS/TNFRSF10B/BID/SESN2/TNFRSF10A/RRM2B/BCL2L1/CASP3/BAX/ATR/ATM/FAS/GADD45A/BBC3/GORAB/COP1/RCHY1/PPM1D/CDKN1A/CASP9/CCNG1/BCL2/CDKN2A/APAF1/GADD45B/CDK2/CHEK1	5.25241585435999
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	61/2128	157/9376	1.71189119295053	SIGLEC10/ADAM17/CASP1/PTGER4/MERTK/HAVCR2/ATP2A2/ABCA1/SGK1/GPR132/HIF1A/CALR/PPARG/NR1H3/CD47/ATP11B/SIRPA/CASP7/DUSP2/VPS8/CAMK2D/ITGAV/IL10/CEBPB/CH25H/ALOX5/ANO6/MAPK13/PPARD/SIRT1/TMEM30A/C1QC/RAB5A/CASP3/PTGS2/MAP2K1/DNMT3A/P2RY6/ADAM9/RAB7A/DUSP5/LIPA/RAB5B/ELMO1/ARNT/ODC1/ADAM10/SCARF1/MAPK1/VPS33A/VPS39/PTGER2/DUSP8/NFATC1/LRP1/SPHK2/STAB1/TIMD4/ARG2/P2RY2/DUSP7	4.87398172605643
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	57/2128	144/9376	1.74404761904762	CXCL8/IL6/TBK1/TNF/SCD/TLR4/IL1B/TRA2A/TRA2B/IRAK1/CHUK/LY96/CCND1/TAB2/CASP8/ADIPOR1/TRAF3/MAPK13/MAP2K3/SREBF1/CXCL1/SIRT1/NFKBIA/C1QC/MYD88/CASP3/C3AR1/ACOX1/ACADM/NFKB1/ACADVL/TRAF6/MAP3K7/RIPK1/FAS/CXCL3/ALDH3A2/IKBKE/CTNNB1/LPIN2/IRAK4/AKT1/ADIPOR2/GSK3B/IL17RA/IKBKB/MAPK9/TAB3/ACACA/ALDH2/FOXO3/MLYCD/C2/PRKAG1/CXCL2/LPIN3/PRKAB2	4.87524490495472
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	39/2128	87/9376	1.97511018926627	PMAIP1/GRB2/NRAS/CCND1/CYCS/POLK/RAF1/KRAS/CASP3/MAP2K1/SMAD4/BAX/MLH1/TGFBR2/MSH6/RALGDS/SOS2/SOS1/CTNNB1/GADD45A/BRAF/MAPK1/AKT1/GSK3B/BBC3/MAPK9/JUN/EREG/FOS/RPS6KB1/TGFA/CDKN1A/CASP9/BCL2/MTOR/AXIN1/RALA/GADD45B/RHOA	4.9509802866674
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	55/2128	138/9376	1.7560204859976	IL18/VAV3/CXCL8/CASP1/IL6/TBK1/FCGR2A/TNF/LCP2/TLR4/NLRP3/IL1B/CCL2/IRAK1/ACTR3/IL10/CHUK/TAB2/SKAP2/MAPK13/MAP2K3/NFKBIA/ARF6/MEFV/MYD88/MAP2K1/GIT2/ELMO2/VAV1/NFKB1/TRAF6/MAP3K7/WIPF1/ACTR2/RPS6KA1/ELMO1/IRAK4/MAPK1/AKT1/GSK3B/NLRC4/ARHGEF7/IKBKB/CDC42/ARPC1B/MAPK9/JUN/GNAQ/LIMK1/NFATC1/FOS/ARPC3/TRAF2/RHOA/ARPC5	4.84781999620813
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	23/2128	42/9376	2.41281775868242	ACSL1/SLC11A2/SAT1/ACSL3/ACSL4/STEAP3/GCLM/SLC39A8/ATG5/PRNP/FTL/HMOX1/LPCAT3/ATG7/SLC3A2/SAT2/ACSL5/MAP1LC3B/VDAC3/CYBB/TF/PCBP1/TFRC	4.9720930750425
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	35/2128	78/9376	1.97705802968961	FCGR2A/TLR2/TNF/IFNGR1/HLA-DQB1/TLR4/IFNGR2/IL1B/FCGR3A/FCGR1A/IRAK1/IL10/TAB2/IL1A/MAPK13/CR1/NFKBIA/MYD88/PTGS2/HLA-DQA1/NCF2/NFKB1/NCF4/NCF1/TRAF6/ITGAM/MAP3K7/IRAK4/MAPK1/JUN/MARCKSL1/CYBB/FOS/HLA-DQA2/FCGR3B	4.69499621319106
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	39/2128	91/9376	1.88829215896885	VAV3/PIK3AP1/LILRB1/FCGR2B/NFKBIE/GRB2/LILRB4/BCL10/CHUK/NRAS/DAPP1/BTK/RAF1/KRAS/PPP3R1/NFKBIA/MAP2K1/LILRA5/VAV1/BLNK/NFKB1/SOS2/LILRA1/SOS1/LYN/MAPK1/AKT1/PPP3CC/RASGRP3/GSK3B/LILRB5/IKBKB/INPP5D/JUN/LILRB3/MALT1/NFATC1/FOS/CD72	4.61368487986163
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	19/2128	33/9376	2.53679653679654	SEC22B/STX6/SNAP23/STX7/GOSR2/STX11/STX3/GOSR1/VTI1A/VAMP7/STX5/STX4/STX2/STX18/BET1/BNIP1/STX17/VAMP1/VAMP8	4.79173206887679
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	36/2128	83/9376	1.91104266690823	IL18/CASP1/IL6/TBK1/MLKL/CGAS/NLRP3/IL1B/CASP7/G3BP1/AIM2/IRF7/GSDME/CHUK/CASP8/CCL4L2/IFI16/NFKBIA/MEFV/CASP3/POLR2K/NFKB1/RIPK1/IKBKE/ADAR/CCL4/IKBKB/POLR3C/CXCL10/DNASE2/POLR3K/RIPK3/POLR3F/PCBP1/POLR1C/SAMHD1	4.5171254508561
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	18/2128	32/9376	2.47838345864662	PMAIP1/CASP7/BIRC2/CASP8/CYCS/BID/BCL2L1/CASP3/BIRC6/BAX/XIAP/BBC3/MAPK9/CASP9/BCL2/APAF1/HTRA2/BIRC3	4.53897746545006
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	57/2128	155/9376	1.62027649769585	FCGR2A/CTSL/SEC22B/TLR2/MSR1/ATP6V1C1/HLA-DQB1/CALR/TLR4/M6PR/FCGR2B/CLEC7A/FCGR3A/STX12/STX7/LAMP1/FCGR1A/ITGAV/ATP6V1B2/ATP6V1H/HLA-F/ATP6V0A1/ATP6V1D/TAP1/RAB5A/HLA-DQA1/ATP6V1A/CTSS/NCF2/TLR6/PIK3C3/NCF4/NCF1/COLEC12/ITGAM/RAB7A/PIKFYVE/OLR1/MARCO/RAB5B/CANX/LAMP2/STX18/ATP6V1G1/SEC61B/TAP2/CD209/CYBB/MRC1/TUBA1B/ATP6V1E2/ATP6V0D2/HLA-DQA2/FCAR/ATP6V1F/FCGR3B/TFRC	4.21914568672301
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	39/2128	95/9376	1.80878512069648	IL18/CXCL8/IL6/CCL3L1/CCL20/CD80/CCL3/CTSL/TLR2/TNF/ATP6V1C1/HLA-DQB1/TLR4/IL1B/CCL2/ICAM1/ATP6V1B2/IL1A/ATP6V1H/ATP6V0A1/CXCL1/ATP6V1D/HLA-DQA1/ATP6V1A/CXCL3/CSF1/TNFSF13B/JUN/ATP6V1G1/TNFSF13/FOS/CD86/IL23A/CXCL12/ATP6V1E2/ATP6V0D2/HLA-DQA2/CXCL2/ATP6V1F	4.29299049461619
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	35/2128	83/9376	1.85795814838301	UBE2D1/PHC2/SCML1/PHC3/MBD5/OGT/JARID2/KDM2A/PCGF5/EZH2/MTF2/EED/RBBP4/LCOR/USP7/USP16/UBE2D3/MGA/SUZ12/RNF2/ASXL2/EP300/TEX10/AEBP2/PHC1/L3MBTL4/PCGF3/FBRS/PHF1/E2F6/SFMBT2/UBE2D4/USP45/PHF19/SKP1	4.25392215820405
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	17/2128	30/9376	2.49674185463659	IL6/TNF/IL1B/CHUK/ABCC3/GART/NFKB1/ABCC5/ABCC1/IKBKB/ATIC/SHMT1/ABCG2/SHMT2/DHFR/SLC19A1/ABCC4	4.44894462337837
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	33/2128	77/9376	1.88829215896885	RB1/CHUK/CCND1/POLK/RAF1/KRAS/STAT3/BCL2L1/MAP2K1/SMAD4/NFKB1/BAX/E2F3/TGFBR2/RALGDS/GADD45A/ARHGEF6/BRAF/MAPK1/AKT1/IKBKB/CDC42/MAPK9/PLD1/RPS6KB1/TGFA/CDKN1A/CASP9/MTOR/CDKN2A/RALA/GADD45B/BRCA2	4.24077689419804
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	41/2128	103/9376	1.75385064603256	CXCL8/IL6/CCL3L1/CCL3/TLR2/TNF/IFNGR1/CALR/TLR4/IFNGR2/IL1B/CCL2/IRAK1/IL10/CHUK/CASP8/GNAI3/MAPK13/PPP2R2A/GNA15/NFKBIA/C1QC/MYD88/TLR6/NFKB1/TRAF6/TGFBR2/PPP2CA/FAS/IRAK4/MAPK1/AKT1/PPP2R2D/IKBKB/MAPK9/JUN/GNAQ/PLCB2/FOS/PLCB3/CFLAR	4.1682729640569
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	53/2128	144/9376	1.62165831244779	ATP2A2/PSMA3/PSMD11/PSMA6/XBP1/PSMA2/CYCS/ATXN2L/NRBF2/PSMC6/OPA1/PSMA1/ATXN1/ITPR2/PSMD12/SP1/PSMC2/PIK3C3/GTF2B/PUM1/PSMA5/PSMC4/PUM2/NFYA/ERN1/PSMD6/VDAC1/AKT1/PPIF/SLC25A5/PSMA4/WIPI1/PSMD9/MCU/ULK2/PRKCA/MAPK9/VDAC3/GNAQ/ATG2B/TBP/PLCB2/TBPL1/ATXN1L/OMA1/ITPR1/ATG101/MTOR/TRAF2/PLCB3/AMBRA1/KCNC3/PIK3R4	4.07330988339585
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	67/2128	193/9376	1.52954926175542	VAV3/CXCL8/CCL3L1/CCL20/CCL8/CCL3/PRKCD/CCR1/GRB2/CCL2/HCK/PREX1/GNB4/FGR/CHUK/RAP1A/ADCY7/NRAS/CCL4L2/GNAI3/RAF1/GNG10/KRAS/STAT2/CXCL1/NFKBIA/STAT3/JAK3/MAP2K1/VAV1/NFKB1/NCF1/SOS2/PAK1/SOS1/PIK3CG/CXCL3/GRK3/ELMO1/CCR5/PIK3R5/LYN/CCL4/BRAF/MAPK1/ARRB2/DOCK2/AKT1/GSK3B/CXCL16/IKBKB/CDC42/CCL18/GNG5/CXCL10/GNAQ/GNGT2/CCL7/PLCB2/CCL23/FOXO3/CXCL12/PLCB3/CXCL2/RAP1B/RHOA/PIK3R6	4.02768119152979
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/2128	78/9376	1.86408328513592	HSPD1/PATL1/HSPA9/DCP2/BTG2/LSM6/XRN1/CNOT4/CNOT2/C1D/LSM8/EXOSC10/LSM5/PNPT1/EXOSC3/CNOT8/CNOT1/DCP1A/BTG3/TOB1/CNOT3/PAN3/MPHOSPH6/BTG1/MTREX/CNOT10/DIS3/EXOSC1/PAN2/TENT4A/ZCCHC7/DCPS/EDC4	4.15212569603834
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	33/2128	78/9376	1.86408328513592	CXCL8/CASP1/IL6/IRF8/TNF/TLR4/NLRP3/IL1B/CASP7/IRAK1/IL10/LY96/IL1A/GNAI3/MAPK13/C1QC/MYD88/CASP3/NFKB1/TRAF6/IRF1/ITGAM/IRAK4/MAPK1/MAPK9/JUN/FOS/IL23A/C2/CALM1/NOD1/TICAM2/RHOA	4.15212569603834
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	39/2128	98/9376	1.75341414761393	PTEN/CDS2/MTMR4/MTMR3/IPMK/MTMR6/PI4K2A/ITPR2/IMPA1/PIK3C3/MTM1/PIP4K2A/PPIP5K2/PIKFYVE/INPP4A/SYNJ1/PI4KB/PIP4K2C/INPP5D/PRKCA/SACM1L/IP6K2/PLCB2/PIP4P1/PPIP5K1/PIP4P2/ITPR1/DGKG/IPPK/PI4K2B/INPP5E/SYNJ2/CALM1/DGKD/INPP5B/CDS1/PLCB3/DGKE/MTMR1	4.06239344311301
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	70/2128	205/9376	1.50449293966624	PMAIP1/GTF2H2/RB1/IRF7/GTF2H1/MDM2/ATF2/GRB2/TRAF1/NRAS/CCND1/CASP8/TRAF3/HLA-F/KRAS/DDX3X/NFKBIA/STAT3/JAK3/CASP3/YWHAG/RASA2/VAC14/LTBR/GTF2B/NFKB1/UBE3A/BAX/GTF2A2/STAT5A/EGR2/GTF2H3/SP100/YWHAH/NFKB2/USP7/POLB/CDKN1B/ATF6B/CCR5/LYN/MAPK1/IRF9/RBL2/EP300/CDKN2B/ACTN1/GTF2H2C/CDC42/EIF2AK2/KAT2B/JUN/HDAC8/VDAC3/TBP/TBPL1/EGR3/GTF2E1/CREB5/KAT2A/CDKN1A/CDKN2A/DNAJA3/TRAF2/ATP6V0D2/RHOA/RBL1/CDK2/CHEK1/REL	3.95718208425277
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	31/2128	73/9376	1.87104748171799	ELL2/PDCD6IP/MX1/APOBEC3G/CCNT2/XPO1/CPSF6/TRIM5/SERINC5/ELL/NUP153/TSG101/MAP1S/CPSF7/AFF4/CCR5/MDFIC/CDK9/EP300/KAT2B/MX2/RAN/NELFCD/RANBP2/KAT2A/BST2/APOBEC3F/NELFA/APOBEC3A/APOBEC3H/SAMHD1	4.04812679305913
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	59/2128	168/9376	1.54735051915503	CASP1/HSP90AA1/GLUL/TNF/IFNGR1/PPID/MLKL/TLR4/IFNGR2/NLRP3/TRPM7/IL1B/TNFAIP3/BIRC2/PYGL/CAMK2D/CHMP5/IL1A/HSP90AB1/CASP8/CYLD/TNFRSF10B/BID/STAT2/TNFRSF10A/STAT3/JAK3/DNM1L/STAT6/BAX/STAT5A/FTL/PLA2G4A/CHMP2B/RIPK1/FAS/PLA2G4C/AIFM1/GLUD1/CHMP7/IFNAR2/XIAP/VDAC1/IRF9/SLC25A5/TLR3/EIF2AK2/PGAM5/MAPK9/VDAC3/CYBB/SQSTM1/RIPK3/BCL2/TRAF2/CFLAR/SPATA2/BIRC3/TICAM2	3.87882224458377
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	38/2128	98/9376	1.70845481049563	VAV3/FCGR2A/FCGR2B/PRKCD/FCGR3A/MARCKS/FCGR1A/HCK/ACTR3/DNM2/RAF1/ARF6/LIMK2/MAP2K1/VAV1/VASP/NCF1/PAK1/PLA2G4A/ASAP1/PLA2G4C/ACTR2/LYN/MAPK1/AKT1/CDC42/ARPC1B/INPP5D/PRKCA/LIMK1/PLD1/MARCKSL1/RPS6KB1/ARPC3/PTPRC/SPHK2/FCGR3B/ARPC5	3.81997363072358
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	30/2128	72/9376	1.83583959899749	TANK/CXCL8/TBK1/AZI2/TNF/TRIM25/IRF7/MAP3K1/CHUK/CASP8/TRAF3/CYLD/ATG5/MAPK13/DDX3X/NFKBIA/IFIH1/NFKB1/SIKE1/TRAF6/CASP10/MAP3K7/RIPK1/IKBKE/ADAR/IKBKB/MAPK9/CXCL10/DHX58/TRAF2	3.85759559932375
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	48/2128	133/9376	1.59014076544745	SOD2/IL6/SGK1/KLF2/PLK3/SGK3/MDM2/GRB2/IL10/CHUK/NRAS/CCND1/PTEN/RAF1/MAPK13/KRAS/SIRT1/BCL6/STAT3/MAP2K1/SMAD4/HOMER3/TGFBR2/ATM/SOS2/SOS1/USP7/NLK/CDKN1B/GADD45A/BRAF/MAPK1/AKT1/RBL2/EP300/CDKN2B/CAT/IKBKB/PLK2/MAPK9/STK11/FOXO3/CDKN1A/AGAP2/PRKAG1/GADD45B/CDK2/PRKAB2	3.71396081491223
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	35/2128	90/9376	1.71345029239766	TLR2/IFNGR1/HIF1A/TLR4/IFNGR2/EML4/NFKBIE/CHUK/NRAS/PTEN/RAF1/MAPK13/KRAS/MAP2K3/PPP3R1/NFKBIA/STAT3/MYD88/MAP2K1/CD274/NFKB1/TRAF6/MAPK1/AKT1/PPP3CC/IKBKB/BATF/JUN/BATF3/NFATC1/FOS/RPS6KB1/MTOR/BATF2/TICAM2	3.68496182453064
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	29/2128	71/9376	1.79963994493275	ADAM17/CXCL8/ATP6V1C1/CHUK/ATP6V1B2/ATP6V1H/MAPK13/ATP6V0A1/CXCL1/NFKBIA/ATP6V1D/CASP3/ATP6V1A/NFKB1/PAK1/HBEGF/CXCL3/ADAM10/LYN/IKBKB/CDC42/MAPK9/JUN/ATP6V1G1/ATP6V1E2/NOD1/ATP6V0D2/CXCL2/ATP6V1F	3.66461051905725
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	31/2128	78/9376	1.75110854058222	PTEN/MTMR4/MTMR3/IPMK/MTMR6/PI4K2A/MINPP1/IMPA1/PIK3C3/MTM1/PIP4K2A/PPIP5K2/PIKFYVE/INPP4A/PIK3CG/SYNJ1/PI4KB/PIP4K2C/INPP5D/SACM1L/FIG4/IP6K2/PLCB2/PPIP5K1/IPPK/PI4K2B/INPP5E/SYNJ2/INPP5B/PLCB3/MTMR1	3.60925517888563
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	110/2128	368/9376	1.3170153644982	TANK/HSPA5/CASP1/TBK1/HNRNPA2B1/TNF/SRSF7/DDIT3/C9orf72/RAB8A/HNRNPA3/PSMA3/PSMD11/PSMA6/NUP58/XBP1/NXF1/PSMA2/SDHD/SPG11/CYCS/ATXN2L/NUP62/NRBF2/PSMC6/NUP98/SETX/BID/MAPK13/MAP2K3/PPP3R1/EIF2S1/PSMA1/DCTN4/RAB1A/UBQLN2/PSMD12/RAB5A/BCL2L1/CASP3/UBQLN1/SRSF3/SDHB/NUP54/PSMC2/TARDBP/PIK3C3/BAX/PSMA5/SMCR8/NDUFB5/NUP153/PSMC4/CHMP2B/ACTR10/POM121C/NXT2/ANXA7/NUP205/FUS/ERN1/PSMD6/VDAC1/PPP3CC/NDUFB3/MT-ND6/DCTN6/UQCRC2/PSMA4/EIF2AK3/ATP5F1C/WIPI1/CAT/MAP1LC3B/PSMD9/MCU/NDUFV2/ULK2/NUP107/NUP160/FIG4/SEH1L/ATG2B/RANBP2/NCBP1/ALS2/NXT1/NUP133/TUBA1B/NDUFA9/NUP88/NUP93/NUP43/CASP9/ATG101/SQSTM1/BCL2/UQCRH/MTOR/NUP155/APAF1/TRAF2/NDUFA7/MT-ND4L/DNAH3/NUP35/AMBRA1/NUP188/PIK3R4/DNAH14	3.36164918643037
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	43/2128	120/9376	1.57882205513784	RIPK2/IRAK3/IRAK2/NFKBIE/PRKCD/GRB2/MAP3K1/IRAK1/CAMK2D/PSEN1/RAP1A/NRAS/RAF1/MAPK13/KRAS/NFKBIA/MAP2K1/NFKB1/BAX/TRAF6/RAPGEF1/SOS2/SOS1/ZNF274/RPS6KA1/IRAK4/BRAF/MAPK1/AKT1/GSK3B/SH2B3/IKBKB/CDC42/MAPK9/JUN/SORT1/FOXO3/SH2B2/BCL2/CALM1/NTRK3/RAP1B/RHOA	3.4576925852537
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	35/2128	93/9376	1.65817770232032	RB1/BIRC2/TRAF1/ITGAV/CHUK/CCND1/PTEN/CYCS/POLK/TRAF3/NFKBIA/BCL2L1/CASP3/PTGS2/NFKB1/BAX/E2F3/TRAF6/CKS2/FHIT/CDKN1B/GADD45A/XIAP/AKT1/CDKN2B/IKBKB/ZBTB17/CDKN1A/CASP9/BCL2/APAF1/TRAF2/BIRC3/GADD45B/CDK2	3.45623148345217
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	32/2128	83/9376	1.69870459280732	SOD2/ACSL1/FAR1/IDH1/ACSL3/ACSL4/AGPS/HSD17B4/SCP2/FAR2/ACOX1/PHYH/ABCD4/PEX2/ACSL5/CAT/PEX13/DHRS4/PEX19/CROT/ABCD3/PRDX1/MLYCD/MPV17L2/HACL1/NUDT19/PEX1/DDO/EHHADH/MPV17L/PXMP4/AMACR	3.4643122802479
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	28/2128	70/9376	1.76240601503759	HIF1A/GRB2/PDGFB/RAP1A/NRAS/VHL/RAF1/KRAS/CUL2/MAP2K1/FLCN/RAPGEF1/SOS2/PAK1/PRCC/SOS1/ELOC/ARNT/BRAF/MAPK1/AKT1/EP300/FH/CDC42/JUN/TGFA/CDKN1A/RAP1B	3.46909479712759
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	30/2128	77/9376	1.71662923542623	RB1/RUNX1/MDM2/GRB2/CHUK/NRAS/CCND1/POLK/RAF1/KRAS/NFKBIA/BCL2L1/MAP2K1/SMAD4/NFKB1/BAX/STAT5A/E2F3/TGFBR2/SOS2/SOS1/CDKN1B/GADD45A/BRAF/MAPK1/AKT1/IKBKB/CDKN1A/CDKN2A/GADD45B	3.42124454507194
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	43/2128	122/9376	1.55293972636509	VAV3/TNF/MAP3K8/LCP2/NFKBIE/GRB2/NCK1/BCL10/IL10/CHUK/NRAS/RAF1/MAPK13/KRAS/PPP3R1/PPP2R2A/NFKBIA/MAP2K1/VAV1/NFKB1/PPP2CA/SOS2/PAK1/MAP3K7/SOS1/PPP2R3C/MAPK1/AKT1/PPP3CC/PPP2R5C/GSK3B/PPP2R2D/IKBKB/CDC42/NCK2/MAPK9/JUN/MALT1/NFATC1/TEC1/FOS/PTPRC/RHOA	3.33085186671339
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	38/2128	106/9376	1.57951482479784	PLAU/HSP90AA1/RB1/ETV5/MDM2/GRB2/PDGFB/CHUK/NRAS/CCND1/HSP90AB1/PTEN/RAF1/KRAS/NFKBIA/MAP2K1/NFKB1/E2F3/SOS2/SOS1/CDKN1B/CTNNB1/BRAF/MAPK1/AKT1/GSK3B/EP300/IKBKB/HSP90B1/TGFA/CREB5/CDKN1A/CASP9/BCL2/MTOR/CDK2/NKX3-1/SLC19A1	3.25117220600992
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/2128	59/9376	1.79227730342806	GRB2/NRAS/CCND1/PTEN/POLK/RAF1/KRAS/MAP2K1/BAX/MLH1/SOS2/SOS1/CTNNB1/GADD45A/CTNNA1/BRAF/MAPK1/AKT1/GSK3B/FOXO3/CDKN1A/CASP9/AXIN1/GADD45B	3.30771079419201
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	37/2128	103/9376	1.58274326593182	DDX39B/ACIN1/NXF1/PABPN1/PAPOLA/RNGTT/EIF4A3/SMG1/CPSF6/PPP2R2A/RNMT/PCF11/TARDBP/PPP1CB/RNPS1/PPP1CC/PPP2CA/NXT2/ETF1/CPSF7/PPP2R3C/DAZAP1/PYM1/FUS/NCBP2/PPP2R5C/WDR33/SYMPK/PPP2R2D/PAPOLG/CPSF3/NCBP1/NXT1/DDX19A/SMG5/CSTF2/CLP1	3.22216743217452
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	64/2128	201/9376	1.40291026072644	PLAU/CXCL8/IL6/BCL2A1/DDIT3/NFKBIZ/PPARG/ETV5/DUSP6/RUNX1/CEBPA/MDM2/CD40/BIRC2/ID2/FCGR1A/ETV6/TRAF1/CCNT2/CEBPB/POLK/AFF1/EWSR1/KDM6A/BMP2K/BCL6/SP1/BCL2L1/DDX5/JMJD1C/ELK4/NFKB1/BAX/ATF1/ITGAM/TGFBR2/ATM/CDK14/PRCC/CDKN1B/MITF/GADD45A/FUS/CDK9/SIN3A/DOT1L/HHEX/LYL1/ZBTB17/MAF/LMO2/PAX8/NSD2/RUNX2/MLF1/CD86/CDKN1A/SS18L1/LDB1/BIRC3/GADD45B/ETV7/SUPT3H/REL	3.12871264502208
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	25/2128	63/9376	1.7484186657119	COLGALT1/ACAT2/SETD2/NSD1/EHMT1/EZH2/ALDH3A2/PHYKPL/DOT1L/DLD/KMT2C/PRDM2/SETDB1/ASH1L/SETDB2/NSD2/KMT5A/KMT2D/ALDH2/TMLHE/KMT2E/SMYD2/KMT5C/CAMKMT/EHHADH	3.22947882476416
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	28/2128	73/9376	1.68997837058399	RB1/EML4/GRB2/NRAS/CCND1/POLK/RAF1/KRAS/STAT3/JAK3/MAP2K1/BAX/STAT5A/E2F3/SOS2/SOS1/FHIT/GADD45A/BRAF/MAPK1/AKT1/PRKCA/TGFA/FOXO3/CDKN1A/CASP9/CDKN2A/GADD45B	3.20662189744627
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	15/2128	32/9376	2.06531954887218	ATG4C/ATG5/PIK3C3/PPP2CA/ATG7/WIPI1/ATG3/ULK2/ATG2B/ATG101/RPTOR/MTOR/ATG16L1/PIK3R4/ATG4D	3.27077619649564
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	37/2128	105/9376	1.55259577515217	TBK1/HIF1A/SMURF2/SIAH1/NRAS/OPA1/KRAS/USP15/EIF2S1/CCZ1/SP1/RAB5A/BCL2L1/ARIH1/RHOT1/CALCOCO2/RAB7A/BCL2L13/RAB5B/MITF/RABGEF1/EIF2AK3/MTX2/MAP1LC3B/PGAM5/MAPK9/JUN/CCZ1B/FOXO3/TFEB/SQSTM1/TRAF2/SMURF1/MFN1/AMBRA1/MUL1/UBB	3.08532754808883
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/2128	109/9376	1.53604193971166	IL6/IL2RA/HSP90AA1/IFNGR1/HLA-DQB1/HIF1A/IFNGR2/AHR/RUNX1/IL1B/NFKBIE/CHUK/HSP90AB1/MAPK13/PPP3R1/IL4R/NFKBIA/STAT3/JAK3/IL1RAP/HLA-DQA1/SMAD4/NFKB1/STAT6/STAT5A/TGFBR2/IL27RA/MAPK1/PPP3CC/IKBKB/MAPK9/JUN/NFATC1/IL6R/FOS/IL23A/MTOR/HLA-DQA2	3.05003480450778
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	89/2128	300/9376	1.30711779448622	HSPA1B/HSPA1A/TNF/LAMTOR3/DDIT3/MKNK1/MAP3K8/HSPA6/DUSP6/IL1B/NF1/HSPA8/DUSP10/TAOK3/DUSP1/RAPGEF2/ATF2/GRB2/DUSP2/MAP3K1/IRAK1/MKNK2/DUSP3/PDGFB/CHUK/RAP1A/NRAS/TAB2/IL1A/RAF1/MAPK13/KRAS/MAP2K3/PPP3R1/PPM1B/MAP4K3/MYD88/CASP3/MAP2K1/IL1RAP/RASA2/ELK4/NFKB1/TRAF6/TGFBR2/SOS2/PAK1/PLA2G4A/MAP3K7/NFKB2/DUSP5/SOS1/FAS/NLK/PLA2G4C/CSF1/RPS6KA1/GADD45A/IRAK4/MAP3K13/BRAF/MAPK1/ARRB2/AKT1/PPP3CC/RASGRP3/IKBKB/MAP3K2/CDC42/PRKCA/MAPK9/JUN/MAP3K12/DUSP8/MAPKAPK3/PTPN7/EREG/NFATC1/FOS/TGFA/ECSIT/TRAF2/RAP1B/NR4A1/MAP3K10/MAP3K21/GADD45B/JUND/DUSP7	2.92941379068821
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	26/2128	68/9376	1.68465280849182	BCL2A1/DUSP6/RUNX1/CEBPA/GRB2/FCGR1A/CHUK/NRAS/CCND1/RAF1/KRAS/PPARD/STAT3/MAP2K1/NFKB1/STAT5A/ITGAM/SOS2/PIM1/SOS1/BRAF/MAPK1/AKT1/IKBKB/RPS6KB1/MTOR	3.07014594340421
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	35/2128	101/9376	1.52683689421574	CXCL8/IL6/TNF/IL1B/PRKCD/CCL2/ICAM1/NRAS/CCND1/IL1A/MAPK13/KRAS/STAT3/CASP3/SMAD4/NFKB1/BAX/STAT5A/TGFBR2/THBD/PIM1/CDKN1B/MAPK1/AKT1/CDC42/DIAPH1/PRKCA/MAPK9/JUN/EGR1/PLCB2/CYBB/NFATC1/BCL2/PLCB3	2.88431219565401
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/2128	63/9376	1.67848191908342	GTF2H2/GTF2H1/CCNH/RAD23B/PCNA/POLR2K/GTF2H3/POLR2B/CUL4A/POLR2M/RAD23A/RPA1/POLD3/GTF2H2C/POLD4/POLR2A/ERCC6/POLR2J3/ERCC8/POLR2J2/POLE/RPA4/ERCC5/RFC5	2.92769687749709
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2128	37/9376	1.90530380004064	PPARG/NRAS/CCND1/POLK/TFG/KRAS/MAP2K1/BAX/CTNNB1/GADD45A/BRAF/MAPK1/PAX8/CDKN1A/GADD45B/TPM3	2.98956069720007
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	133/2128	480/9376	1.22083333333333	TANK/HSPA5/IL6/TBK1/ATP2A2/TNF/DDIT3/C9orf72/PPID/RAB8A/PSMA3/PSMD11/PSMA6/IL1B/CASP7/XBP1/PSMA2/SDHD/CAMK2D/SPG11/PSEN1/NRAS/IL1A/CASP8/CYCS/LRRK2/ATXN2L/NRBF2/PSMC6/RAF1/BID/MAPK13/KRAS/MAP2K3/PPP3R1/EIF2S1/PSMA1/DCTN4/RAB1A/ATXN1/UBE2G1/ITPR2/PSMD12/UBE2J1/RAB5A/BCL2L1/CASP3/PTGS2/MAP2K1/SDHB/PSMC2/FZD5/TARDBP/PIK3C3/PRNP/NFKB1/BAX/PSMA5/SMCR8/UBE2G2/FZD2/NDUFB5/PSMC4/CHMP2B/ACTR10/FAS/DVL3/CSF1/CTNNB1/FUS/ERN1/PSMD6/VDAC1/BRAF/MAPK1/PPP3CC/NDUFB3/PPIF/MT-ND6/SLC25A5/DCTN6/UQCRC2/GSK3B/PSMA4/EIF2AK3/ATP5F1C/WIPI1/CAT/MAP1LC3B/PSMD9/CSNK1A1/MCU/NDUFV2/ULK2/PRKCA/MAPK9/HTT/SNCA/FIG4/VDAC3/GNAQ/ATG2B/PLCB2/ALS2/CYBB/ATXN1L/TUBA1B/NDUFA9/ITPR1/CHRFAM7A/CASP9/ATG101/SQSTM1/FRAT2/BCL2/UQCRH/MTOR/AXIN1/APAF1/CALM1/TRAF2/NDUFA7/MT-ND4L/DNAH3/MFN1/PLCB3/AMBRA1/HTRA2/MAP3K10/PIK3R4/DNAH14/DKK2/UBB	2.69122629290509
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	17/2128	41/9376	1.82688428388043	NBN/ATM/RPA1/POLD3/MRE11/UIMC1/POLD4/TOPBP1/PALB2/RAD50/RAD51B/RAD51D/TOP3A/RAD52/BRCA2/RPA4/BARD1	2.87502656914379
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/2128	41/9376	1.82688428388043	CXCL8/DAPK1/RB1/MDM2/NRAS/CCND1/RAF1/KRAS/MAP2K1/E2F3/HBEGF/BRAF/MAPK1/CDKN1A/CDKN2A/TYMP/DAPK2	2.87502656914379
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	16/2128	38/9376	1.85516422635536	UGP2/HK2/HK3/GALK2/HEXA/GNPDA1/NAGK/PGM2/RENBP/CHIT1/GALE/GNPNAT1/UAP1L1/PGM3/FPGT/GNPDA2	2.86204689960864
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	41/2128	125/9376	1.44517293233083	TNF/NSMAF/CERS2/NRAS/SGMS1/PTEN/SGPP1/GNAI3/RAF1/BID/MAPK13/KRAS/PPP2R2A/SPTLC1/ORMDL1/DEGS1/MAP2K1/ADORA3/NFKB1/BAX/FCER1G/PPP2CA/PPP2R3C/ABCC1/MAPK1/AKT1/PPP2R5C/GNA13/PPP2R2D/ASAH1/PRKCA/MAPK9/GNAQ/PLD1/PLCB2/BCL2/TRAF2/SPHK2/PLCB3/RHOA/CTSD	2.7148871000001
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	27/2128	75/9376	1.58616541353383	PMAIP1/MDM2/BIRC2/CASP8/CYCS/BID/SLC31A1/BCL2L1/CASP3/BAX/TOP2B/MLH1/MSH6/ATM/FAS/XIAP/MAPK1/AKT1/BBC3/GSTO1/ATP7A/CDKN1A/CASP9/BCL2/CDKN2A/APAF1/BIRC3	2.76152104131309
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	31/2128	90/9376	1.51762740183793	SOD2/PPARG/SESN1/ATF2/EIF4E/ADCY7/NRAS/ADIPOR1/ATG5/KRAS/SIRT1/SESN2/EHMT1/NFKB1/BAX/RHEB/ATF6B/AKT1/ADIPOR2/CAT/TSC1/STK11/RPS6KB1/FOXO3/AKT1S1/CREB5/ATG101/RPTOR/MTOR/PRKAG1/PRKAB2	2.67353904739952
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	25/2128	69/9376	1.59638225999782	VAV3/TNF/LCP2/GRB2/NRAS/BTK/ALOX5/RAF1/MAPK13/KRAS/MAP2K3/MAP2K1/VAV1/FCER1G/SOS2/PLA2G4A/SOS1/ALOX5AP/PLA2G4C/LYN/MAPK1/AKT1/INPP5D/PRKCA/MAPK9	2.69405689069087
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/2128	76/9376	1.56529481598734	RB1/MDM2/GRB2/CAMK2D/PDGFB/NRAS/CCND1/PTEN/POLK/RAF1/KRAS/MAP2K1/BAX/E2F3/SOS2/SOS1/GADD45A/BRAF/MAPK1/AKT1/PRKCA/TGFA/CDKN1A/MTOR/CDKN2A/CALM1/GADD45B	2.68103622696226
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	49/2128	158/9376	1.36642238507662	RB1/MDM2/CCND1/CCNH/ESCO1/YWHAG/WAPL/CUL1/SMAD4/PCNA/STAG1/E2F4/E2F3/ATR/PPP2CA/ATM/CDC27/YWHAH/ANAPC10/CDKN1B/GADD45A/ANAPC7/CDC26/BUB3/PPP2R5C/GSK3B/RBL2/EP300/CDKN2B/HDAC8/ZBTB17/CDC23/PRKDC/ANAPC4/DBF4/CDKN1A/CDKN2A/ORC6/ANAPC1/FBXO5/SKP1/DBF4B/GADD45B/RBL1/CDK2/WEE1/BUB1/CHEK1/DDX11	2.51683385101927
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	36/2128	110/9376	1.44196855775803	IL6/IFNGR1/MKNK1/HIF1A/TLR4/IFNGR2/HK2/HK3/EIF4E/CAMK2D/MKNK2/VHL/STAT3/CUL2/MAP2K1/LTBR/PFKFB3/PDK1/NFKB1/HMOX1/ALDOA/ELOC/CDKN1B/ARNT/MAPK1/AKT1/EP300/PRKCA/CYBB/IL6R/RPS6KB1/CDKN1A/BCL2/MTOR/TF/TFRC	2.52641055140164
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/2128	18/9376	2.20300751879699	MANBA/FUCA1/NEU1/NEU3/HEXA/ENGASE/MAN2B1/MAN2C1/NEU4	2.76805956600882
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	39/2128	122/9376	1.40848021693578	SCD/RAB8A/PPARG/RAB10/CCND1/ADIPOR1/SREBF1/PPP2R2A/SIRT1/CAB39/PFKFB3/RHEB/PPP2CA/ELAVL1/MAP3K7/PPP2R3C/AKT1/ADIPOR2/PPP2R5C/PPP2R2D/HMGCR/TSC1/STK11/ACACA/RPS6KB1/CRTC2/EEF2K/STRADB/FOXO3/AKT1S1/PFKFB4/FBP1/CREB5/RPTOR/MTOR/MLYCD/STRADA/PRKAG1/PRKAB2	2.46064268530722
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	33/2128	100/9376	1.45398496240602	IL18/CXCL8/IL6/CCL3L1/CCL20/IL2RA/CCL8/CCL3/TNF/CCR1/CCL2/IL10/IL10RA/CCL4L2/TNFRSF10B/CXCL1/TNFRSF10A/LTBR/IL10RB/CXCL3/TNFRSF10D/CSF1/CCR5/TNFRSF14/CCL4/CCL18/CXCL10/CCL7/IL6R/CCL23/CXCL12/ACKR3/CXCL2	2.47299623637547
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/2128	82/9376	1.50449293966624	HSPA1B/HSPA1A/HSPA5/HSP90AA1/CTSL/TNF/IFI30/HLA-DQB1/CALR/HSPA6/HSPA8/HSPA4/CTSB/HSP90AB1/HLA-F/TAP1/LGMN/HLA-DQA1/CTSS/RFX5/NFYC/NFYA/CANX/CIITA/TAP2/PDIA3/HLA-DQA2/B2M	2.48612546787775
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	31/2128	93/9376	1.46867167919799	PRKCD/GRB2/MAP3K1/CAMK2D/ADCY7/NRAS/RAF1/MAPK13/KRAS/MAP2K3/ITPR2/MAP2K1/SOS2/PLA2G4A/SOS1/HBEGF/PLA2G4C/MAPK1/MAP3K2/CDC42/PRKCA/MAPK9/JUN/EGR1/GNAQ/PLD1/PLCB2/ITPR1/MMP14/CALM1/PLCB3	2.46109494037246
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	43/2128	138/9376	1.37288874359813	MKNK1/HK2/GRB2/PYGL/HK3/EIF4E/MKNK2/NRAS/RAF1/KRAS/SREBF1/SOCS3/SOCS1/MAP2K1/PHKB/PPP1CB/PPP1CC/RHEB/SOCS4/RAPGEF1/SOS2/SOS1/RHOQ/BRAF/MAPK1/AKT1/GSK3B/PPP1R3B/IKBKB/MAPK9/TSC1/PPP1R3E/PRKAR1A/EXOC7/ACACA/RPS6KB1/SH2B2/FBP1/RPTOR/MTOR/CALM1/PRKAG1/PRKAB2	2.39106947636556
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	48/2128	157/9376	1.34706192232173	CXCL8/IL6/TNF/DDIT3/PPARG/NR1H3/IL1B/CASP7/XBP1/CEBPA/SDHD/MLX/IL1A/CASP8/CYCS/ADIPOR1/BID/MAPK13/SREBF1/SOCS3/EIF2S1/CASP3/SDHB/NFKB1/BAX/NDUFB5/FAS/ERN1/AKT1/NDUFB3/ADIPOR2/UQCRC2/GSK3B/EIF2AK3/IKBKB/CDC42/NDUFV2/MAPK9/JUN/IL6R/FOS/NDUFA9/UQCRH/TRAF2/NDUFA7/PRKAG1/MLXIPL/PRKAB2	2.37616855490958
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	44/2128	142/9376	1.36524409615588	HSP90AA1/CTSL/TNF/KLF2/IL1B/SDC4/DUSP1/CCL2/ARHGEF2/ITGAV/ICAM1/PDGFB/CHUK/IL1A/HSP90AB1/SDC2/MAPK13/NCF2/SUMO1/NFKB1/NCF1/HMOX1/MAP3K7/THBD/TRPV4/MEF2A/CTNNB1/AKT1/ACVR1/IKBKB/GSTO1/HSP90B1/MAPK9/JUN/SUMO4/TXN/PIAS4/FOS/SQSTM1/BCL2/CALM1/SUMO2/RHOA/NFE2L2	2.37626460663764
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/2128	13/9376	2.37246963562753	XRCC4/LIG4/DCLRE1C/MRE11/PRKDC/RAD50/FEN1	2.68305309537549
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	23/2128	66/9376	1.5354294827979	IL18/IL6/TLR2/TNF/IFNGR1/HLA-DQB1/TLR4/IFNGR2/IL1B/IL10/IL1A/IL4R/STAT3/HLA-DQA1/NFKB1/STAT6/JUN/MAF/NFATC1/NOD2/IL23A/TLR5/HLA-DQA2	2.36516675770654
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	32/2128	99/9376	1.42416647679806	RB1/MDM2/GRB2/ADCY7/NRAS/CCND1/RAF1/MAPK13/KRAS/SP1/MAP2K1/BAX/E2F3/SOS2/SOS1/HBEGF/CDKN1B/BRAF/MAPK1/AKT1/NCOA3/NOTCH2/MAPK9/DLL1/JUN/FOS/RPS6KB1/CDKN1A/BCL2/MTOR/CDKN2A/JAG1	2.29885997308319
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	20/2128	56/9376	1.57357679914071	MGAT4A/MAN1A1/STT3B/ALG13/MGAT2/OSTC/B4GALT1/RPN1/ALG2/DPM1/MGAT5/MOGS/ST6GAL1/MGAT1/ALG8/MAN1C1/ALG1/ALG6/ALG11/ALG9	2.33259849483141
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	38/2128	122/9376	1.37236533957845	ATP2A2/HIF1A/MDM2/ITGAV/NRAS/CCND1/RAF1/KRAS/MAP2K1/MED13/RHEB/ATP1A1/MED14/MED30/NCOA2/CTNNB1/MAPK1/AKT1/NCOA3/SIN3A/GSK3B/EP300/MED17/NOTCH2/KAT2B/PRKCA/RCAN1/ATP1B1/PLCB2/SLC9A1/FXYD2/KAT2A/CASP9/MTOR/PLCB3/THRB/MED27/SLC16A10	2.24309038995568
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	50/2128	168/9376	1.31131399928392	IL6/IL2RA/IFNGR1/SOCS6/IFNGR2/IL15RA/PTPN2/GRB2/OSM/MCL1/IL10/IL10RA/PDGFB/CCND1/STAM2/PIAS1/RAF1/STAT2/SOCS3/IL4R/STAT3/JAK3/SOCS1/BCL2L1/IL10RB/STAT6/STAT5A/CSF3R/SOCS4/SOS2/PIM1/SOS1/PIAS2/IL27RA/IFNAR2/AKT1/IRF9/EP300/IL13RA1/IL7/PIAS4/CISH/IL6R/IL23A/CDKN1A/BCL2/MTOR/LIF/IL3RA/IFNLR1	2.20613961842393
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/2128	67/9376	1.5125126248457	CAMK2D/RAP1A/NRAS/PPP1R1A/RAF1/KRAS/PPP3R1/ITPR2/MAP2K1/PPP1CB/PPP1CC/RPS6KA1/BRAF/MAPK1/PPP3CC/EP300/PRKCA/GNAQ/PLCB2/ITPR1/CALM1/PLCB3/RAP1B	2.28114457937075
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	36/2128	115/9376	1.37927427263812	SGK1/MAFB/ARHGEF11/ATF2/ADCY7/GNAI3/RAF1/ITPR2/PDE4B/SP1/MAP2K1/HBEGF/MEF2A/ATF6B/BRAF/MAPK1/ARRB2/GNA13/OXSR1/VDR/PRKCA/EGR1/GNAQ/PLD1/PLCB2/RUNX2/FOS/ITPR1/CREB5/MMP14/CDKN1A/BCL2/PLCB3/CYP27B1/RHOA/JUND	2.21735750373689
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	24/2128	71/9376	1.48935719580642	SOCS6/GRB2/NRAS/CCND1/RAF1/MAPK13/KRAS/SOCS3/STAT3/SOCS1/MAP2K1/NFKB1/STAT5A/SOCS4/IRF1/SOS2/SOS1/MAPK1/AKT1/GSK3B/MAPK9/CISH/FOS/FOXO3	2.24263875096855
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/2128	23/9376	1.91565871199738	PCNA/MLH1/MSH6/RPA1/POLD3/POLD4/PMS2/MLH3/RPA4/RFC5	2.38223411854273
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/2128	20/9376	1.98270676691729	HSD17B7/LBR/MSMO1/LIPA/SQLE/LSS/SC5D/CYP27B1/CYP2R1	2.38372524295292
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	36/2128	116/9376	1.36738397718434	ME2/IDH1/HK2/ADPGK/SDHD/HK3/RPE/ACAT2/SDS/SDSL/ACO1/HIBCH/PRPS1/SDHB/ACOX1/DLAT/MDH1/ME1/ALDOA/PGP/GLUD1/SUCLA2/IDH3A/CAT/FH/DLD/ACSS2/FBP1/TALDO1/MCEE/GOT1/SHMT1/SHMT2/RPIA/GPT2/AMT	2.15727778037696
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	14/2128	37/9376	1.66714082503556	UGP2/HK2/HK3/GALK2/NANS/NAGK/TGDS/PGM2/GALE/GNPNAT1/UAP1L1/PGM3/FPGT/NANP	2.20308142960894
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/2128	44/9376	1.60218728639781	GTF2H2/GTF2H1/TAF7/CCNH/GTF2F2/GTF2B/GTF2A2/TAF12/GTF2H3/TAF9/GTF2H2C/TBP/TBPL1/GTF2I/TAF8/GTF2E1	2.16936641896582
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/2128	44/9376	1.60218728639781	MBD4/PCNA/PARG/PARP4/POLB/POLG2/POLD3/POLD4/POLG/PNKP/TDP1/SMUG1/POLE/FEN1/MUTYH/RFC5	2.16936641896582
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	26/2128	80/9376	1.43195488721805	IL6/NF1/GRB2/EIF4E/PDGFB/NRAS/PTEN/RAF1/KRAS/STAT3/BCL2L1/MAP2K1/BAX/SOS2/SOS1/BRAF/MAPK1/AKT1/GSK3B/PRKCA/IL6R/RPS6KB1/TGFA/FOXO3/BCL2/MTOR	2.10231449995752
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	31/2128	99/9376	1.37966127439812	HIF1A/GPCPD1/GRB2/PDGFB/NRAS/RAF1/KRAS/SP1/MAP2K1/CHPT1/RHEB/RALGDS/SOS2/PLA2G4A/SOS1/PLA2G4C/CHKA/MAPK1/AKT1/PRKCA/MAPK9/JUN/TSC1/PLD1/FOS/RPS6KB1/DGKG/MTOR/DGKD/DGKE/CHKB	2.05765461153856
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	104/2128	388/9376	1.18099372141694	ADAM17/IL6/SLC11A2/ATP2A2/TNF/DDIT3/PPID/PSMA3/PSMD11/PSMA6/IL1B/CASP7/XBP1/PSMA2/SDHD/PSEN1/CHUK/NRAS/IL1A/SLC39A8/CASP8/CYCS/NRBF2/PSMC6/RAF1/BID/KRAS/PPP3R1/EIF2S1/PSMA1/ITPR2/PSMD12/CASP3/PTGS2/MAP2K1/SDHB/PSMC2/FZD5/PIK3C3/NCSTN/APOE/NFKB1/SLC39A11/PSMA5/FZD2/NDUFB5/PSMC4/FAS/DVL3/CSF1/CTNNB1/IDE/ADAM10/ERN1/PSMD6/VDAC1/BRAF/MAPK1/AKT1/PPP3CC/NDUFB3/PPIF/MT-ND6/SLC25A5/UQCRC2/GSK3B/PSMA4/EIF2AK3/ATP5F1C/WIPI1/IKBKB/PSMD9/CSNK1A1/EIF2AK2/MCU/NDUFV2/ULK2/MAPK9/SNCA/VDAC3/GNAQ/ATG2B/PLCB2/CYBB/TUBA1B/NDUFA9/ITPR1/LRP1/CHRFAM7A/CASP9/ATG101/FRAT2/UQCRH/MTOR/AXIN1/APAF1/CALM1/TRAF2/NDUFA7/MT-ND4L/PLCB3/AMBRA1/PIK3R4/DKK2	1.97292328392197
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	12/2128	31/9376	1.7055542081009	GLUL/ACAT2/ACO1/MDH1/PGP/CAT/DLD/ACSS2/MCEE/SHMT1/SHMT2/AMT	2.13198398569375
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/2128	52/9376	1.52515905147484	ABCA1/APOC1/MYLIP/STARD3NL/NPC1/NCEH1/APOE/LIPA/ANGPTL4/VAPA/VDAC1/STARD3/SORT1/VDAC3/LRP1/LDLRAP1/LDLR/APOC2	2.05756589321371
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	8/2128	18/9376	1.95822890559733	LMBRD1/ZNF143/MMADHC/ABCD4/PRDX1/MTRR/MMAA/MMAB	2.20483633486953
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2128	45/9376	1.56658312447786	ABCG1/ABCA1/ABCC3/TAP1/ABCC5/ABCA5/ABCD4/ABCC1/ABCC10/TAP2/ABCD3/ABCB4/DEFB1/ABCB10/ABCG2/ABCC4	2.06427786111219
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/2128	28/9376	1.73093447905478	ATP6V1C1/ATP6V1B2/ATP6V0A1/ATP6V1D/ATP6V1A/SLC12A7/CA2/ATP6V1G1/ATP6V1E2/ATP6V0D2/ATP6V1F	2.09874884453714
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/2128	93/9376	1.37391866763683	MAML2/IL2RA/IFNGR1/HLA-DQB1/IFNGR2/NFKBIE/CHUK/MAPK13/PPP3R1/IL4R/NFKBIA/JAK3/HLA-DQA1/NFKB1/STAT6/STAT5A/MAPK1/PPP3CC/NOTCH2/IKBKB/MAML1/MAPK9/DLL1/JUN/MAF/NFATC1/FOS/HLA-DQA2/JAG1	1.96352666883261
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	27/2128	86/9376	1.38328379087253	GRB2/NCK1/CAMK2D/ABL2/NRAS/RAF1/KRAS/MAP2K1/STAT5A/SOS2/PAK1/SOS1/HBEGF/CDKN1B/BRAF/MAPK1/AKT1/GSK3B/NCK2/PRKCA/MAPK9/JUN/EREG/RPS6KB1/TGFA/CDKN1A/MTOR	1.9347469895229
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/2128	46/9376	1.53252696959791	PSMA3/PSMD11/PSMA6/PSMA2/PSME4/PSMC6/PSMA1/PSMD12/PSMC2/PSMA5/PSMC4/PSMD6/PSMA4/PSMD9/PSMB9/PSMB10	1.96174276221169
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/2128	39/9376	1.58164642375169	MAT2A/MTHFS/MTHFD2/MAT2B/GART/MTHFD2L/DLD/MTHFD1L/ATIC/SHMT1/SHMT2/AHCYL2/DHFR/AMT	1.97219586529314
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/2128	57/9376	1.46867167919799	ACSL1/SCD/ACSL3/ACSL4/ELOVL5/HSD17B4/ACAT2/SCP2/HADHB/ACOX1/ACADM/ACADVL/HSD17B12/ACSL5/ACACA/HACD4/ELOVL7/PPT1/EHHADH	1.92302017462803
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/2128	62/9376	1.42129517341741	HSPA1B/SOD2/HSPA1A/HSPA6/HSPA8/ADCY7/NRAS/ATG5/KRAS/SIRT1/AKT1/CAT/CLPB/RPS6KB1/FOXO3/AKT1S1/RPTOR/MTOR/PRKAG1/PRKAB2	1.80333565401559
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/2128	44/9376	1.50205058099795	MGAT4A/MAN1A1/STT3B/ALG13/MGAT2/OSTC/HEXA/B4GALT1/RPN1/ALG2/MGAT1/MAN1C1/ALG1/ALG11/ALG9	1.80862614611849
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	42/2128	149/9376	1.24196397032851	CXCL8/LPAR6/CYTH1/GRB2/DNM2/PDGFB/ADCY7/NRAS/RAF1/KRAS/ARF6/MAP2K1/LPAR5/RHEB/FCER1G/RALGDS/SOS2/PLA2G4A/SOS1/PIK3CG/PLA2G4C/CYTH4/PIK3R5/MAPK1/AKT1/GNA13/AGPAT3/PRKCA/TSC1/PLD1/PLCB2/DGKG/ARF1/MTOR/RALA/SPHK2/DGKD/PLCB3/DGKE/RHOA/PIK3R6/LPAR2	1.61315438758482
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	7/2128	17/9376	1.81424148606811	PAPSS1/SEPHS2/TXNRD1/SCLY/SEPSECS/PAPSS2/PSTK	1.82064520169733
NA	NA	hsa04981	Folate transport and metabolism	11/2128	31/9376	1.56342469075916	MTHFS/ABCC3/ABCC5/ABCC1/SLCO2B1/SHMT1/ABCG2/SHMT2/DHFR/SLC19A1/ABCC4	1.70250904048353
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	39/2128	139/9376	1.23622004651918	HSPA1B/HSPA1A/FKBP4/HSP90AA1/HSPA6/PRKCD/HSPA8/ATF2/GRB2/FKBP5/ADCY7/NRAS/HSP90AB1/GNAI3/RAF1/KRAS/ITPR2/SP1/MAP2K1/SOS2/SOS1/HBEGF/NCOA2/ATF6B/MAPK1/AKT1/NCOA3/HSP90B1/JUN/GNAQ/PLCB2/FOS/TGFA/ITPR1/CREB5/BCL2/CALM1/PLCB3/CTSD	1.52027108931688
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/2128	21/9376	1.67848191908342	DPYD/BCAT1/PANK3/CSAD/AASDHPPT/ALDH3A2/ALDH2/VNN1	1.68650793052866
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	17/2128	54/9376	1.38707880813144	POLK/ATR/MLH1/RPA1/PALB2/REV1/PMS2/FANCL/RMI1/POLI/UBE2T/FAN1/TOP3A/TELO2/FANCG/BRCA2/RPA4	1.54562482103143
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	39/2128	140/9376	1.22738990332975	KLF2/GNB4/ADCY7/NRAS/CCND1/GNAI3/SLC8A1/RAF1/GNG10/KRAS/ITPR2/TFAM/MAP2K1/SMAD4/PIK3C3/PIK3CG/MEF2A/PIK3R5/MAPK1/AKT1/GNA13/MAP1LC3B/EGR1/GNG5/GNAQ/GNGT2/PLCB2/SLC9A1/RPS6KB1/ITPR1/MTOR/CALM1/SPHK2/PRKAG1/PLCB3/PIK3R4/JAG1/PIK3R6/PRKAB2	1.46877607760802
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2128	32/9376	1.51456766917293	HIBCH/ACOX1/ECHDC1/SUCLA2/DLD/ACSS2/ACACA/MLYCD/MCEE/BCKDHB/EHHADH	1.57984117122308
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	19/2128	62/9376	1.35023041474654	ADAM17/MAML2/DTX2/NUMB/PSEN1/DTX3L/ATXN1/NCSTN/SPEN/TLE4/DVL3/EP300/NOTCH2/MAML1/KAT2B/DLL1/ATXN1L/KAT2A/JAG1	1.49914604743726
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	31/2128	109/9376	1.25308684555425	IL6/TNF/NR1H3/PRKCD/PYGL/MLX/PTEN/SREBF1/SOCS3/NFKBIA/STAT3/OGT/NFKB1/PPP1CB/PPP1CC/RPS6KA1/AKT1/GSK3B/PPP1R3B/IKBKB/MAPK9/PPP1R3E/RPS6KB1/CRTC2/CREB5/SLC27A4/MTOR/PPARGC1B/PRKAG1/MLXIPL/PRKAB2	1.44004345614966
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	12/2128	36/9376	1.46867167919799	RNASEH2B/PCNA/RPA1/POLD3/POLD4/PRIM2/POLA2/POLA1/POLE/RPA4/FEN1/RFC5	1.52654243298076
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	21/2128	70/9376	1.3218045112782	ACSL1/TNF/ACSL3/NFKBIE/ACSL4/CHUK/ADIPOR1/SOCS3/NFKBIA/STAT3/NFKB1/AKT1/ADIPOR2/ACSL5/IKBKB/MAPK9/STK11/MTOR/TRAF2/PRKAG1/PRKAB2	1.46427275460612
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	21/2128	70/9376	1.3218045112782	CD80/HLA-DQB1/CD40/ICAM1/ABL2/CCND1/CASP8/CYCS/BID/HLA-F/CASP3/HLA-DQA1/EIF4G3/SNTB1/EIF4G2/EIF4G1/CD55/CD86/CASP9/HLA-DQA2/CXADR	1.46427275460612
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/2128	55/9376	1.36185919343814	UGCG/CERS2/SGMS1/SGPP1/ACER3/NEU1/SPTLC1/GLA/DEGS1/B4GALT5/GALC/NEU3/HEXA/ASAH1/GM2A/NEU4/SPHK2	1.45831740551201
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	31/2128	110/9376	1.2416951469583	TNF/SMURF2/ZFYVE16/ID2/ACVR1B/TGIF1/SKIL/SP1/CUL1/SMAD4/E2F4/TGFBR2/PPP2CA/NRROS/LEMD3/MAPK1/SIN3A/EP300/CDKN2B/ACVR1/SMAD7/RPS6KB1/HAMP/ID3/SMURF1/TGIF2/SKP1/RHOA/TF/RBL1/TFRC	1.38159414007983
Organismal Systems	Immune system	hsa04611	Platelet activation	35/2128	126/9376	1.22389306599833	FCGR2A/LCP2/SNAP23/RAP1A/ADCY7/APBB1IP/BTK/FERMT3/GNAI3/MAPK13/ITPR2/VASP/PPP1CB/PPP1CC/FCER1G/PLA2G4A/PIK3CG/PLA2G4C/PIK3R5/P2RY1/LYN/PTGS1/MAPK1/AKT1/GNA13/PTGIR/GNAQ/PLCB2/ITPR1/MYL12A/PLCB3/VAMP8/RAP1B/RHOA/PIK3R6	1.37093671525594
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2128	37/9376	1.42897785003048	IL18/IL6/TNF/IL1B/ICAM1/IL10/MYD88/FAS/PRKCA/GNAQ/PLCB2/PLCB3	1.41660216201781
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/2128	12/9376	1.83583959899749	FCGR2B/NPC1/NECTIN4/CD209/SLAMF1	1.56980323870875
Organismal Systems	Nervous system	hsa04730	Long-term depression	18/2128	60/9376	1.3218045112782	NRAS/GNAI3/RAF1/KRAS/ITPR2/MAP2K1/PPP2CA/PLA2G4A/PLA2G4C/LYN/BRAF/MAPK1/GNA13/PRKCA/GNAQ/PLCB2/ITPR1/PLCB3	1.3549253584012
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/2128	30/9376	1.46867167919799	IDH1/SDHD/ACO1/SDHB/DLAT/MDH1/SUCLA2/IDH3A/FH/DLD	1.39308882212283
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	22/2128	76/9376	1.27542540561931	ACSL1/PLIN2/SCD/GK/PPARG/ACSL3/NR1H3/ACSL4/HMGCS1/PPARD/SCP2/ACOX1/ACADM/ME1/FABP5/OLR1/ANGPTL4/ACSL5/DBI/SLC27A4/FABP3/EHHADH	1.30626616308417
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/2128	34/9376	1.42547545333923	NFIL3/BHLHE41/BHLHE40/CUL1/FBXL3/CSNK1D/PER1/CRY1/PRKAG1/SKP1/PRKAB2	1.34665514416262
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/2128	23/9376	1.53252696959791	NUS1/HMGCS1/ACAT2/IDI1/ZMPSTE24/DHDDS/HMGCR/PDSS1	1.38545497290471
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2128	61/9376	1.3001355848638	SLC11A2/TRPM7/SLC8A1/SLC31A1/FTL/HMOX1/ATP1A1/MT1X/MT1F/SLC30A1/VDR/ATP7A/ATP1B1/FXYD2/MT1G/ATP2B1/TF/MT1H	1.27424616482048
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	45/2128	170/9376	1.16629809818664	RB1/TXNRD1/GRB2/NRAS/CCND1/PTEN/POLK/RAF1/KRAS/SMARCE1/BCL2L1/MAP2K1/SMAD4/FZD5/ARID2/BAX/E2F3/HMOX1/TGFBR2/SOS2/FZD2/PBRM1/SOS1/DVL3/BRD7/CTNNB1/GADD45A/ARID1B/BRAF/MAPK1/ACTL6A/AKT1/GSK3B/CSNK1A1/GSTO1/PRKCA/RPS6KB1/TGFA/CDKN1A/FRAT2/MTOR/CDKN2A/AXIN1/GADD45B/NFE2L2	1.18560116032054
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/2128	27/9376	1.46867167919799	SCD/ELOVL5/HSD17B4/SCP2/ACOX1/HSD17B12/HACD4/ELOVL7/ACOT2	1.32138803715071
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	44/2128	166/9376	1.16785940755503	ATP2A2/KCNMA1/ATF2/ADCY7/GNAI3/SLC8A1/RAF1/PPP3R1/ITPR2/MAP2K1/ADORA3/VASP/PPP1CB/PPP1CC/ATP1A1/ADRB2/PIK3CG/MEF2A/ATF6B/PIK3R5/VDAC1/MAPK1/AKT1/PPP3CC/PPIF/SLC25A5/KCNMB1/GNA13/VDAC3/GNAQ/ATP1B1/PLCB2/GTF2I/NFATC1/ITPR1/FXYD2/CREB5/ADRA2B/CALM1/PLCB3/ATP2B1/RGS2/RHOA/PIK3R6	1.18231247654945
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	41/2128	154/9376	1.17302997754126	GCH1/KMO/KYNU/ALAS1/CMPK2/UGP2/MAT2A/MTHFD2/GCLM/NADK/BCAT1/PANK3/PDXK/PNPO/MAT2B/RDH11/AK6/COQ2/MTHFD2L/MOCS2/ALDH3A2/DLD/MTHFD1L/GGCX/TPK1/ADSL/PTS/ALDH2/NADSYN1/CPOX/COQ5/NADK2/NME7/GPHN/EARS2/COQ7/CTPS1/SHMT1/SHMT2/MMAB/DHFR	1.17309048053414
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	15/2128	50/9376	1.3218045112782	IL18/CXCL8/IL6/TLR2/TNF/TLR4/IL1B/CD40/CCL2/ICAM1/IL10/SDC2/CR1/MYD88/LRP1	1.23620866201151
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2128	20/9376	1.54210526315789	NPL/UGP2/CYB5R4/NANS/TGDS/UAP1L1/NANP	1.31497008429155
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/2128	51/9376	1.29588677576294	ATP6V1C1/PDIA4/ATP6V1B2/ATP6V1H/ATP6V0A1/ATP6V1D/ATP6V1A/ERO1A/PRKCA/ATP6V1G1/SEC61B/ARF1/ATP6V1E2/ATP6V0D2/ATP6V1F	1.14801769178949
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/2128	10/9376	1.76240601503759	PAPSS1/SQOR/SUOX/PAPSS2	1.30698798442153
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	83/2128	333/9376	1.0981959403012	MAML2/PTGER4/TBK1/TNF/ATP6V1C1/RB1/MX1/MDM2/GRB2/OASL/ITGAV/PSEN1/CHUK/NRAS/ATP6V1B2/CCND1/CASP8/PTEN/ATP6V1H/TRAF3/RAF1/HLA-F/KRAS/STAT2/PPP2R2A/ATP6V0A1/ATP6V1D/CASP3/PTGS2/MAP2K1/ATP6V1A/FZD5/NFKB1/UBE3A/BAX/RHEB/IRF1/ATR/PPP2CA/ATM/SOS2/FZD2/SOS1/FAS/DVL3/IKBKE/PPP2R3C/CDKN1B/CTNNB1/IFNAR2/MAPK1/AKT1/IRF9/PPP2R5C/GSK3B/RBL2/TLR3/EP300/PPP2R2D/NOTCH2/IKBKB/CDC42/MAML1/CSNK1A1/EIF2AK2/MX2/TSC1/ATP6V1G1/TBP/TBPL1/HES4/RPS6KB1/CREB5/CDKN1A/MTOR/ATP6V1E2/AXIN1/ATP6V0D2/JAG1/ATP6V1F/RBL1/CDK2/ITGA10	0.988602586095337
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	28/2128	104/9376	1.18623481781377	ETNK1/GPCPD1/GPD2/SGMS1/CDS2/LPGAT1/LPCAT2/CHPT1/CEPT1/LPCAT3/PLA2G4A/PLA2G4C/LYPLA2/CRLS1/LPIN2/CHKA/ACHE/AGPAT3/PLD1/PGS1/SELENOI/DGKG/DGKD/CDS1/DGKE/PLA1A/LPIN3/CHKB	1.03479231392834
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	77/2128	308/9376	1.1015037593985	SOD2/SLC1A3/PPARG/PSMA3/PSMD11/PSMA6/PSMA2/SDHD/CASP8/CYCS/NRBF2/PSMC6/PSMA1/DCTN4/PSMD12/SP1/TFAM/CASP3/SDHB/PSMC2/POLR2K/PIK3C3/BAX/PSMA5/NDUFB5/PSMC4/ACTR10/POLR2B/ERN1/PSMD6/VDAC1/NDUFB3/PPIF/MT-ND6/SIN3A/SLC25A5/DCTN6/UQCRC2/BBC3/PSMA4/EP300/ATP5F1C/WIPI1/PSMD9/NDUFV2/ULK2/MAPK9/HTT/VDAC3/GNAQ/ATG2B/TBP/POLR2A/PLCB2/TBPL1/POLR2J3/TUBA1B/NDUFA9/ITPR1/CREB5/CASP9/ATG101/CLTA/UQCRH/MTOR/APAF1/TRAF2/NDUFA7/MT-ND4L/DNAH3/KCNJ10/PLCB3/AMBRA1/MAP3K10/PIK3R4/POLR2J2/DNAH14	0.981440753491647
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/2128	48/9376	1.28508771929825	HMGCS1/ACAT2/BCAT1/HADHB/HIBCH/ACADM/ALDH3A2/AACS/DLD/ALDH2/HIBADH/MCEE/BCKDHB/EHHADH	1.07291969457789
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	35/2128	133/9376	1.1594776414721	VAV3/TNF/IFNGR1/LCP2/IFNGR2/FCGR3A/LAT2/GRB2/ICAM1/NRAS/RAF1/TNFRSF10B/BID/KRAS/PPP3R1/TNFRSF10A/CASP3/MAP2K1/SH3BP2/MICB/VAV1/FCER1G/SOS2/PAK1/CD48/SOS1/FAS/IFNAR2/BRAF/MAPK1/PPP3CC/PRKCA/NFATC1/MICA/FCGR3B	1.0036481903312
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	17/2128	60/9376	1.2483709273183	NRAS/RAF1/MAPK13/KRAS/PPP3R1/PTGS2/MAP2K1/PLA2G4A/PLA2G4C/MAPK1/AKT1/PPP3CC/CDC42/PRKCA/MAPKAPK3/CASP9/SPHK2	1.04574067770685
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	40/2128	154/9376	1.14441949028415	TRPM2/CAMK2D/ADCY7/NRAS/CCND1/GNAI3/RAF1/KRAS/PPP3R1/ITPR2/PTGS2/MAP2K1/PPP1CB/PPP1CC/PLA2G4A/PIK3CG/PLA2G4C/PIK3R5/MAPK1/PPP3CC/CD38/PRKCA/JUN/KCNJ2/GNAQ/RCAN1/PLCB2/NFATC1/FOS/EEF2K/ITPR1/CDKN1A/PPP1R12B/CALM1/PRKAG1/PLCB3/RGS2/RHOA/PIK3R6/PRKAB2	0.979120101980808
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/2128	204/9376	1.12310187232788	PLAU/VAV3/CTSL/TLR2/TNF/HIF1A/TLR4/PLAUR/SDC4/HPSE/MDM2/GRB2/CAMK2D/ITGAV/NRAS/CCND1/RAF1/SDC2/MAPK13/KRAS/STAT3/ITPR2/CASP3/DDX5/MAP2K1/CD44/FZD5/VAV1/PPP1CB/PPP1CC/HCLS1/SOS2/PAK1/FZD2/SOS1/FAS/HBEGF/CTNNB1/BRAF/MAPK1/AKT1/CDC42/PRKCA/SLC9A1/RPS6KB1/ITPR1/MSN/CDKN1A/MTOR/PPP1R12B/RHOA/ANK2	0.963185812220729
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2128	14/9376	1.57357679914071	B3GNT2/B3GNT7/B4GALT1/ST3GAL1/B4GALT4	1.16368016864671
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/2128	93/9376	1.18441264451451	SMURF2/PTPRJ/RAP1A/CTNND1/SMAD4/PDCD10/TGFBR2/MAP3K7/NLK/CTNNB1/CTNNA1/MAPK1/NECTIN4/EP300/FER/ACTN1/CDC42/FARP2/ACP1/CCM2/MYL12A/SMURF1/RAP1B/RHOA/SNAI1	0.968390125752904
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	40/2128	155/9376	1.13703613873393	RB1/AHR/ATF2/CAMK2D/RAP1A/ADCY7/CCND1/GNAI3/ITPR2/SP1/NCEH1/MAP2K1/FZD5/E2F3/FZD2/DVL3/RBBP5/PDE8A/CDKN1B/CTNNB1/ARNT/ATF6B/BRAF/MAPK1/GSK3B/CDKN2B/FH/GNAQ/PLCB2/KMT2D/ITPR1/CREB5/CDKN1A/CDKN2A/AXIN1/PLCB3/RAP1B/NR4A1/LDLR/CDK2	0.932125327675959
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/2128	122/9376	1.15567607543449	ATF2/GRB2/MAP3K1/ADCY7/NRAS/GNAI3/RAF1/MAPK13/KRAS/MAP2K3/SOCS3/STAT3/ITPR2/SOCS1/MAP2K1/STAT5A/SOS2/SOS1/ATF6B/MAPK1/AKT1/GSK3B/EP300/PRKCA/MAPK9/GNAQ/PLCB2/FOS/ITPR1/CREB5/MTOR/PLCB3	0.937776617846415
Human Diseases	Cancer: specific types	hsa05218	Melanoma	20/2128	73/9376	1.20712740756	RB1/MDM2/PDGFB/NRAS/CCND1/PTEN/POLK/RAF1/KRAS/MAP2K1/BAX/E2F3/MITF/GADD45A/BRAF/MAPK1/AKT1/CDKN1A/CDKN2A/GADD45B	0.962608842478647
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	38/2128	148/9376	1.13127413127413	RB1/GRB2/NRAS/CCND1/PTEN/POLK/RAF1/KRAS/SP1/MAP2K1/FZD5/BAX/E2F3/SOS2/FZD2/NFKB2/SOS1/DVL3/CTNNB1/GADD45A/BRAF/MAPK1/AKT1/NCOA3/GSK3B/NOTCH2/CSNK1A1/DLL1/JUN/FOS/RPS6KB1/CDKN1A/FRAT2/MTOR/AXIN1/JAG1/GADD45B/BRCA2	0.872205006890677
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	68/2128	275/9376	1.08948735475051	HSPA1B/HSPA1A/HSPA5/IL6/STIP1/TNF/DDIT3/HSPA6/PSMA3/PSMD11/PSMA6/IL1B/PRKCD/HSPA8/PSMA2/SDHD/ATF2/IL1A/CYCS/PSMC6/MAPK13/PPP3R1/EIF2S1/PSMA1/ITPR2/PSMD12/C1QC/CASP3/SDHB/PSMC2/NCF2/PRNP/NCF4/NCF1/BAX/PSMA5/NDUFB5/PSMC4/ATF6B/PSMD6/VDAC1/MAPK1/PPP3CC/NDUFB3/PPIF/MT-ND6/SLC25A5/UQCRC2/GSK3B/PSMA4/EIF2AK3/ATP5F1C/PSMD9/MCU/NDUFV2/MAPK9/EGR1/VDAC3/CYBB/TUBA1B/NDUFA9/ITPR1/CREB5/CASP9/UQCRH/APAF1/NDUFA7/MT-ND4L	0.81610458523243
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/2128	34/9376	1.29588677576294	POLR2K/POLR2B/POLR2M/POLR3C/POLR2A/POLR2J3/POLR3K/POLR3F/POLR2J2/POLR1C	0.936499263456125
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2128	54/9376	1.22389306599833	MAT2A/AMD1/GCLM/LACC1/BCAT1/SMS/APIP/SDS/SDSL/MAT2B/MDH1/DNMT3A/ENOPH1/GOT1/AHCYL2	0.894016083531848
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/2128	38/9376	1.27542540561931	NAMPT/NT5C2/NADK/SIRT1/NNT/SIRT6/BST1/CD38/SIRT7/NADSYN1/NADK2	0.921788358226568
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/2128	50/9376	1.23368421052632	SAT1/CNDP2/P4HA1/AMD1/LAP3/SMS/OAT/ALDH3A2/ODC1/SAT2/ALDH2/GOT1/GATM/ARG2	0.897695448956024
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	43/2128	170/9376	1.11446262715613	RAB8A/RUNX1/RAP2C/HSPA4/RAPGEF2/RAB8B/MAP3K1/NEDD4L/ACTR3/ARHGEF2/RAP1A/CCND1/PPP2R2A/PCNA/WHAMM/VASP/HCLS1/PPP2CA/ACTR2/SYMPK/PPP2R2D/ACTN1/CDC42/ARPC1B/ARHGAP17/MAPK9/JUN/STK11/CLDN23/TUBA1B/MSN/TJAP1/MYL12A/ARPC3/OCLN/PRKAG1/YBX3/CD1D/RHOA/MICALL2/PRKAB2/CLDN15/ARPC5	0.81604675609297
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/2128	75/9376	1.1749373433584	HSPA5/PDIA4/ATF2/GSR/ADCY7/ITPR2/ATP1A1/ATF6B/CANX/HSP90B1/PRKCA/GNAQ/TTF2/ATP1B1/PLCB2/PAX8/ITPR1/FXYD2/CREB5/PLCB3	0.824158408943276
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/2128	19/9376	1.39137316976652	HPSE/ARSB/HEXA/GALNS/GNS/SGSH	0.925255963888637
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7/2128	23/9376	1.34096109839817	GLS/MDH1/ATP1A1/GLUD1/CA2/ATP1B1/FXYD2	0.887065400085707
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/2128	43/9376	1.22958559188669	ACSL1/ACSL3/ACSL4/ACAT2/HADHB/ACOX1/ACADM/ACADVL/ALDH3A2/ACSL5/ALDH2/EHHADH	0.817580608207371
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/2128	31/9376	1.27916565607567	DPYD/CNDP2/HIBCH/ACOX1/CSAD/ALDH3A2/ALDH2/MLYCD/EHHADH	0.843559150063083
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/2128	35/9376	1.25886143931257	HK2/HK3/TIGAR/PFKFB3/ALDOA/ENOSF1/PFKFB4/FBP1/FPGT/AKR1B1	0.831317753644881
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/2128	56/9376	1.18018259935553	SMURF2/CCND1/SPOPL/CUL1/CSNK1G3/CUL3/GRK3/ARRB2/CSNK1D/GSK3B/CSNK1A1/BCL2/SMURF1/HHAT/PTCH2	0.732759171363237
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/2128	12/9376	1.46867167919799	COQ2/GGCX/COQ5/COQ7	0.880219507162025
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2128	16/9376	1.37687969924812	GLA/HEXA/NAGA/ST3GAL1/B3GALNT1	0.817498885575314
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	8/2128	28/9376	1.25886143931257	B3GNT5/ST3GAL6/GCNT2/FUT4/B3GNT2/B4GALT1/B4GALT4/B3GALNT1	0.743274756110877
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2128	24/9376	1.28508771929825	HS3ST3B1/HS3ST1/HS2ST1/HS3ST2/B3GALT6/GLCE/NDST2	0.757694682004751
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/2128	128/9376	1.1015037593985	ENPP4/AMPD3/PAPSS1/NT5C2/ADCY7/LACC1/DCK/ENTPD1/PDE7A/PDE4B/NUDT9/RRM2B/GMPR/PRPS1/GART/AK6/PDE6D/HPRT1/FHIT/PDE8A/PGM2/ATIC/NTPCR/PAICS/ADSL/PDE1B/NME7/PDE6A/PDE6G/PRUNE1/PAPSS2/PPAT	0.626506468746787
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	26/2128	103/9376	1.11219797065479	CXCL8/IL6/TLR2/TNF/TLR4/IL1B/SERPINB9/IL10/CXCL1/GNA15/RAB5A/CASP3/NFKB1/ITGAM/RAB7A/CXCL3/RAB5B/ACTN1/PRKCA/GNAQ/PLCB2/PRDX1/PLCB3/CXCL2/CD1D/ARG2	0.620377219497962
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2128	37/9376	1.1908148750254	GLS/GLUL/GLUD1/NIT2/RIMKLB/ADSL/GOT1/DDO/GPT2/PPAT	0.630122894426681
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/2128	33/9376	1.20164046479836	IDH1/BCAT1/ACO1/DLAT/IDH3A/DLD/GOT1/BCKDHB/GPT2	0.628715030534612
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/2128	75/9376	1.11619047619048	GLUL/IDH1/MAT2A/RPE/BCAT1/SDS/SDSL/ACO1/MAT2B/PRPS1/ALDOA/IDH3A/TALDO1/GOT1/SHMT1/SHMT2/RPIA/GPT2/ARG2	0.547392318604732
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2128	17/9376	1.29588677576294	GLUL/GLUD1/CA2/CA5B/CA13	0.661603280790612
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/2128	17/9376	1.29588677576294	NRP2/LAMP1/LAMP2/CD209/TFRC	0.661603280790612
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/2128	50/9376	1.14556390977444	IL6/CD80/HLA-DQB1/IL15RA/CD40/IL10/HLA-DQA1/LTBR/TNFSF13B/TNFSF13/CD86/CXCL12/HLA-DQA2	0.559182235900535
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/2128	71/9376	1.11701789685481	GLS/IDH1/HIF1A/HK2/HK3/NRAS/PTEN/TIGAR/RAF1/KRAS/MAP2K1/PDK1/SIRT6/MAPK1/AKT1/SLC7A5/MTOR/NTRK3	0.536272629262119
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	57/2128	238/9376	1.05522208883553	ADAM17/CXCL8/CASP1/IL6/TBK1/FCGR2A/TLR2/TNF/TLR4/CGAS/MX1/NLRP3/IL1B/OAS2/CCL2/OAS1/IRAK1/CHUK/TAB2/TRAF3/MAPK13/STAT2/NFKBIA/STAT3/C1QC/MYD88/C3AR1/IFIH1/NRP1/RPL22L1/NFKB1/TRAF6/MAP3K7/HBEGF/IKBKE/IFNAR2/OAS3/ADAR/IRAK4/RPS10/MAPK1/IRF9/TLR3/IKBKB/EIF2AK2/PRKCA/MAPK9/MX2/JUN/CXCL10/TLR8/RPL36A/CYBB/IL6R/FOS/C2/RPS27L	0.467560796315026
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/2128	38/9376	1.1594776414721	CD40/BTK/JAK3/TAP1/RFX5/BLNK/DCLRE1C/CIITA/TAP2/PTPRC	0.533736649950154
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	27/2128	110/9376	1.08147641831852	HSP90AA1/ADCY7/HSP90AB1/GNAI3/STK10/RAF1/MAPK13/KRAS/CPEB2/MAP2K1/CDC27/ANAPC10/RPS6KA1/ANAPC7/BRAF/MAPK1/AKT1/CDC26/MAPK9/CPEB3/CDC23/ANAPC4/CPEB4/SPDYA/ANAPC1/CDK2/BUB1	0.465741011022386
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/2128	47/9376	1.12494000959846	ME2/ACAT2/DLAT/MDH1/ME1/ALDH3A2/FH/DLD/ACYP1/ACSS2/ACACA/ALDH2	0.465259527268782
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	37/2128	154/9376	1.05858802851284	KCNE1/ATP2A2/ATF2/CAMK2D/ADCY7/GNAI3/SLC8A1/PPP1R1A/MAPK13/PPP2R2A/SCN1B/PPP1CB/PPP1CC/PPP2CA/ATP1A1/ADRB2/PIK3CG/PPP2R3C/ATF6B/PIK3R5/MAPK1/AKT1/PPP2R5C/PPP2R2D/PRKCA/GNAQ/ATP1B1/PLCB2/SLC9A1/FXYD2/CREB5/BCL2/CALM1/PLCB3/ATP2B1/PIK3R6/TPM3	0.397208966320815
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	36/2128	150/9376	1.05744360902256	RB1/GRB2/NRAS/CCND1/POLK/RAF1/KRAS/MAP2K1/SMAD4/FZD5/BAX/E2F3/MLH1/TGFBR2/SOS2/FZD2/SOS1/DVL3/CDKN1B/CTNNB1/GADD45A/CTNNA1/BRAF/MAPK1/AKT1/GSK3B/CDKN2B/CSNK1A1/RPS6KB1/CDKN1A/FRAT2/BCL2/MTOR/AXIN1/GADD45B/CDK2	0.384275750722574
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	26/2128	107/9376	1.07062047642471	ATF2/PYGL/CAMK2D/PPP3R1/SIRT1/PPP4C/ITPR2/PHKB/PPP4R3B/SIK1/PPP4R3A/AKT1/PPP3CC/EP300/GNAQ/PLCB2/ACACA/CRTC2/ITPR1/SIK2/FBP1/CREB5/CALM1/PRKAG1/PLCB3/PRKAB2	0.398078249153505
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2128	18/9376	1.22389306599833	ACSL1/ACSL3/ACSL4/ACSL5/ACACA	0.515166641451642
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/2128	39/9376	1.12974744553692	CD80/TNF/HLA-DQB1/CD40/IL10/HLA-F/HLA-DQA1/FAS/CD86/HLA-DQA2	0.439936300080306
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	63/2128	268/9376	1.03574234092694	HSPA5/SLC11A2/DDIT3/PSMA3/PSMD11/PSMA6/XBP1/DUSP1/PSMA2/SDHD/CAMK2D/SLC39A8/CYCS/GNAI3/LRRK2/PSMC6/EIF2S1/PSMA1/UBE2G1/ITPR2/PSMD12/UBE2J1/BCL2L1/CASP3/SDHB/PSMC2/BAX/SLC39A11/PSMA5/UBE2G2/NDUFB5/PSMC4/ERN1/PSMD6/VDAC1/NDUFB3/PPIF/MT-ND6/SLC25A5/UQCRC2/PSMA4/EIF2AK3/ATP5F1C/PSMD9/MCU/NDUFV2/MAPK9/SNCA/VDAC3/TXN/TUBA1B/NDUFA9/ITPR1/CASP9/UQCRH/APAF1/CALM1/NDUFA7/MT-ND4L/MFN1/HTRA2/NFE2L2/UBB	0.321663095273937
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	33/2128	138/9376	1.05361229159856	CAMK2D/ADCY7/MAPK13/PPP3R1/CPEB2/ITPR2/MAP2K1/YWHAG/CUL1/PPP1CB/PPP1CC/PPP2CA/CDC27/YWHAH/ANAPC10/RPS6KA1/ANAPC7/MAPK1/PPP3CC/CDC26/PPP2R5C/CPEB3/CDC23/ANAPC4/ITPR1/CPEB4/CALM1/SPDYA/ANAPC1/FBXO5/SKP1/CDK2/BUB1	0.343777376496743
NA	NA	hsa04517	IgSF CAM signaling	70/2128	299/9376	1.03150853722936	VAV3/CD80/NRP2/LCP2/EPB41L3/MTSS1/RAPGEF2/PMP22/GRB2/SRGAP2/NCK1/ACTR3/TRIO/ICAM1/RAP1A/MAPK13/CD2AP/ARF6/MAP2K1/IL1RAP/ITGAX/NRP1/VAV1/ERC1/TRAF6/ITGAM/PAK1/CD48/ACTR2/CTNNB1/SRGAP1/LYN/CD226/MAPK1/NECTIN4/AKT1/GSK3B/DOK1/ACTN1/CDC42/NCK2/ARPC1B/INPP5D/PRKCA/MAPK9/CRTAM/SPTAN1/CD209/SLAMF7/PLXNA1/TUBA1B/CD84/EPB41L1/CD86/MSN/MYL12A/ARPC3/GLDN/NTRK3/SLAMF1/RAP1B/PLXNA2/RHOA/L1CAM/PPFIA4/DYNLL1/SLAMF6/ANK2/CXADR/ARPC5	0.300023329156114
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/2128	31/9376	1.13703613873393	RPE/PRPS1/ALDOA/DERA/PGM2/FBP1/TALDO1/RPIA	0.41408420485286
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	28/2128	117/9376	1.05443094916779	CDK2AP2/GATAD2A/SMARCE1/ARID2/RBBP4/ING3/BAZ1A/TFPT/PBRM1/BRD7/ARID1B/EPC1/ACTL6A/PHF6/DPF2/EPC2/INO80D/BCL7B/INO80/EP400/MBD2/ACTR8/INO80C/SS18L1/MRGBP/BICRA/MTA1/ACTR5	0.321010437949569
Genetic Information Processing	Transcription	hsa03040	Spliceosome	57/2128	243/9376	1.03350970017637	HSPA1B/HSPA1A/SRSF7/DDX39B/HNRNPA3/HSPA6/ACIN1/TRA2A/TRA2B/HSPA8/SRSF1/SRSF6/EIF4A3/SRSF5/HNRNPC/SRSF2/LSM6/DHX15/SRSF10/THOC1/DDX5/SRSF3/RBMXL1/PPIL1/SNRPA1/HNRNPU/EFTUD2/LSM8/AQR/SRSF9/LSM5/SNRNP40/PRPF3/THOC3/SF3B1/BCAS2/PHF5A/SF3A3/FUS/U2AF2/RBM22/NCBP2/PRPF18/CDC40/SMNDC1/SRSF4/CHERP/PRPF38A/SNRPF/BUD13/NCBP1/USP39/PPIH/THOC6/PPIE/SRSF8/PCBP1	0.286767088952326
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/2128	44/9376	1.1015037593985	HSPD1/CD80/TNF/HLA-DQB1/IL1B/IL1A/HLA-F/HLA-DQA1/FAS/CD86/HLA-DQA2	0.365665054729198
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2128	23/9376	1.14939522719843	GLS/GLUL/GLUD1/GOT1/GPT2/ARG2	0.3886758272667
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/2128	32/9376	1.1015037593985	UGP2/HK2/HK3/GLA/B4GALT1/PGM2/GALE/AKR1B1	0.311639902268663
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/2128	45/9376	1.07702589807853	IL6/CD80/TNF/HLA-DQB1/IL1B/IL1A/HLA-F/HLA-DQA1/FAS/CD86/HLA-DQA2	0.280634648768128
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/2128	115/9376	1.03445570447859	CAMK2D/GNB4/ADCY7/NRAS/GNAI3/GNG10/KRAS/ITPR2/MAP2K1/PIK3CG/PIK3R5/MAPK1/AKT1/ACHE/PRKCA/GNG5/KCNJ2/GNAQ/GNGT2/PLCB2/FOS/ITPR1/CHRFAM7A/CREB5/BCL2/PLCB3/PIK3R6	0.20143895957065
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2128	28/9376	1.1015037593985	ELOVL5/HADHB/HSD17B12/HACD4/ELOVL7/PPT1/ACOT2	0.291450059968788
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/2128	133/9376	1.02696591101815	ATF2/CAMK2D/GNB4/GNAI3/MAPK13/GNG10/PPP2R2A/ITPR2/COMT/PPP1CB/PPP1CC/PPP2CA/PPP2R3C/ATF6B/ARRB2/AKT1/PPP3CC/PPP2R5C/GSK3B/PPP2R2D/PRKCA/MAPK9/GNG5/GNAQ/GNGT2/PLCB2/FOS/ITPR1/CREB5/CALM1/PLCB3	0.169705844306268
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/2128	59/9376	1.04549509366637	DPYD/CMPK2/NT5C2/NT5C3A/DCK/ENTPD1/RRM2B/UPP1/DCTPP1/CDADC1/NME7/UCKL1/CTPS1/TYMP	0.18993932017477
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/2128	116/9376	1.02553798288826	VAV3/ICAM1/RAP1A/GNAI3/MAPK13/CTNND1/NCF2/VAV1/VASP/NCF4/NCF1/ITGAM/CTNNB1/CTNNA1/ACTN1/CDC42/PRKCA/CLDN23/CYBB/MSN/MYL12A/CXCL12/RHOH/OCLN/RAP1B/RHOA/CLDN15	0.149958970619005
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	41/2128	178/9376	1.01486863225479	CACYBP/SIAH1/CAMK2D/PSEN1/CCND1/TBL1XR1/PPP3R1/PPARD/SIRT1/CUL1/SMAD4/FZD5/FZD2/MAP3K7/TLE4/NLK/DVL3/CTNNB1/PPP3CC/RYK/GSK3B/EP300/CTNNBIP1/CSNK1A1/PRKCA/MAPK9/JUN/INVS/PLCB2/LZTS2/NFATC1/FOSL1/SENP2/FRAT2/AXIN1/PLCB3/GPC4/SKP1/RHOA/DKK2/PRICKLE3	0.108516724499164
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	23/2128	99/9376	1.0236196551986	PTGER4/IL1B/PRKCD/CAMK2D/ADCY7/MAPK13/MAP2K3/ITPR2/IL1RAP/PPP1CB/PPP1CC/PLA2G4A/TRPV4/PLA2G4C/PRKCA/MAPK9/PTGER2/GNAQ/PLCB2/ITPR1/CALM1/PLCB3/P2RY2	0.128011719181535
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	30/2128	130/9376	1.01677270098323	ATF2/GRB2/GNB4/ADCY7/NRAS/GNAI3/RAF1/MAPK13/GNG10/KRAS/GNA15/NFKBIA/MAP2K1/NFKB1/TGFBR2/SOS2/SOS1/ATF6B/MAPK1/ARRB2/AKT1/PRKCA/MAPK9/JUN/GNG5/GNGT2/PLCB2/FOS/CREB5/PLCB3	0.104342225119451
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/2128	227/9376	1.0093074094929	SOD2/HIF1A/AHR/PRKCD/SDHD/GRB2/PTPRJ/ABL2/CHUK/NRAS/PTEN/RAF1/MAPK13/KRAS/NFKBIA/MAP2K1/SDHB/NCF2/PRKD3/NFKB1/NCF1/HMOX1/SOS2/NDUFB5/SOS1/ARNT/VDAC1/BRAF/MAPK1/AKT1/NDUFB3/PPIF/MT-ND6/SLC25A5/UQCRC2/ATP5F1C/CAT/IKBKB/NDUFV2/GSTO1/MAPK9/JUN/VDAC3/PLD1/ACP1/FOS/FOXO3/NDUFA9/UQCRH/NDUFA7/MT-ND4L/NFE2L2	0.0769161068759322
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/2128	29/9376	1.06352087114338	MOB1B/MOB1A/SAV1/LIMD1/LATS1/PAK1/RASSF4	0.185627228618271
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/2128	69/9376	1.02168464639861	PTGER4/KCNMA1/CTSB/GNAI3/PPP3R1/ITPR2/ADRB2/PPP3CC/PTGER2/KCNJ2/GNAQ/PLCB2/ITPR1/PDE1B/CALM1/PLCB3	0.0979567552069216
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	23/2128	100/9376	1.01338345864662	IL6/IL2RA/TNF/HLA-DQB1/IL1B/FCGR1A/IL1A/IL4R/CR1/HLA-DQA1/CD44/CSF3R/ITGAM/CSF1/CD55/CD38/CD33/IL7/IL6R/HLA-DQA2/IL3RA/CD1D/TFRC	0.0729038307510493
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/2128	47/9376	1.03119500879859	TNF/HK2/PRKCD/HK3/SOCS3/SOCS1/SOCS4/MAPK1/IKBKB/MAPK9/MTOR	0.116165951110644
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/2128	79/9376	1.00390216046445	SLC1A3/ATP6V1C1/DNM2/ATP6V1B2/NSF/ATP6V1H/ATP6V0A1/STX3/ATP6V1D/ATP6V1A/STX2/ATP6V1G1/UNC13B/CLTA/ATP6V1E2/SLC6A12/ATP6V0D2/ATP6V1F	0.0188716386553602
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/2128	30/9376	1.0280701754386	PIGA/PIGK/PIGN/PIGG/PIGF/PIGC/PIGB	0.0834363358704584
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	49/2128	217/9376	0.99490662139219	HSP90AA1/RB1/AHR/PTGES3/ATF2/GRB2/ADCY7/NRAS/CCND1/HSP90AB1/GNAI3/RAF1/KRAS/BCL6/STAT3/MAP2K1/KLF4/KPNA4/NFKB1/STAT5A/SOS2/SOS1/ADRB2/IKBKE/RPS6KA1/ARNT/ATF6B/XIAP/MAPK1/ARRB2/AKT1/NOTCH2/VDR/KPNA1/GSTO1/HSP90B1/PRKCA/DLL1/JUN/KPNA2/FOS/RPS6KB1/CHRFAM7A/CREB5/KPNA5/BCL2/MTOR/PAQR5/JAG1	-0.041131462798575
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/2128	53/9376	0.997588310398638	DNM2/SLC8A1/ATP1A1/VDR/PRKCA/GNAQ/ATP1B1/PLCB2/FXYD2/CLTA/PLCB3/ATP2B1	-0.00953990085340021
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/2128	26/9376	1.01677270098323	LMBRD1/ABCD4/ABCC1/SLC19A2/SLC5A6/SLC19A1	0.0464030183583665
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/2128	17/9376	1.03670942061035	HSD17B4/CH25H/SCP2/AMACR	0.0820823203372509
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/2128	89/9376	0.990115738785165	GRB2/PDGFB/ADCY7/NRAS/GNAI3/RAF1/KRAS/ITPR2/MAP2K1/SOS2/SOS1/MAPK1/CSNK1D/MAP3K2/PRKCA/GNAQ/PLCB2/TUBA1B/ITPR1/PLCB3	-0.0507649370940587
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	17/2128	76/9376	0.985555995251286	CAMK2D/ADCY7/GNAI3/HRH2/ITPR2/ATP1A1/CA2/PRKCA/KCNJ2/GNAQ/ATP1B1/PLCB2/SLC9A1/ITPR1/CALM1/KCNJ10/PLCB3	-0.0685039007939256
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	19/2128	85/9376	0.984873949579832	CMPK2/AMPD3/NT5C2/NT5C3A/LACC1/DCK/ENTPD1/RRM2B/GMPR/UPP1/AK6/DCTPP1/HPRT1/NTPCR/ADSL/NME7/UCKL1/CTPS1/TYMP	-0.0759042571290828
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/2128	31/9376	0.99490662139219	HSPA5/SRP54/SPCS3/SRP9/SRPRA/SEC61B/IMMP2L	-0.015390740357363
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2128	22/9376	1.00136705399863	CNDP2/HNMT/ALDH3A2/ALDH2/CARNMT1	0.00347824912733142
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/2128	36/9376	0.979114452798663	UGP2/HK2/PYGL/HK3/GBE1/GYG1/PGM2/AMY2B	-0.0680277376551138
Human Diseases	Immune disease	hsa05310	Asthma	7/2128	32/9376	0.963815789473684	TNF/HLA-DQB1/CD40/IL10/HLA-DQA1/FCER1G/HLA-DQA2	-0.111093854049477
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	80/2128	362/9376	0.973704980683753	IL6/IL2RA/PIK3AP1/HSP90AA1/TLR2/SGK1/LPAR6/TLR4/SGK3/MDM2/ATF2/GRB2/OSM/EIF4E/MCL1/ITGAV/GNB4/PDGFB/CHUK/NRAS/CCND1/HSP90AB1/PTEN/RAF1/GNG10/KRAS/PPP2R2A/IL4R/JAK3/BCL2L1/MAP2K1/YWHAG/LPAR5/NFKB1/CSF3R/RHEB/PPP2CA/SOS2/YWHAH/SOS1/PIK3CG/CSF1/PPP2R3C/CDKN1B/ATF6B/PIK3R5/IFNAR2/MAPK1/AKT1/PPP2R5C/GSK3B/RBL2/PPP2R2D/IKBKB/HSP90B1/PRKCA/GNG5/IL7/TSC1/GNGT2/DDIT4/STK11/EREG/IL6R/RPS6KB1/CRTC2/TGFA/FOXO3/CREB5/CDKN1A/CASP9/RPTOR/BCL2/MTOR/NR4A1/IL3RA/CDK2/PIK3R6/LPAR2/ITGA10	-0.276459399440727
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/2128	51/9376	0.95031696889282	AGPS/PLA2G7/LPCAT2/CHPT1/CEPT1/PLA2G4A/PLA2G4C/PAFAH1B1/TMEM86A/PLD1/SELENOI	-0.192766299019959
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	25/2128	115/9376	0.957829355998692	DUSP1/GNB4/NRAS/GNAI3/ALOX5/RAF1/GNG10/KRAS/ITPR2/CASP3/PTGS2/MAP2K1/PLA2G4A/PLA2G4C/BRAF/PTGS1/MAPK1/ALOX15B/PRKCA/GNG5/GNAQ/GNGT2/PLCB2/ITPR1/PLCB3	-0.246542939132958
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/2128	65/9376	0.948987854251012	ATF2/ADCY7/ITPR2/SP1/NCEH1/PDE8A/ATF6B/GNAQ/PLCB2/ITPR1/CREB5/PLCB3/NR4A1/LDLR	-0.223611669725305
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/2128	65/9376	0.948987854251012	NRAS/RAF1/KRAS/ITPR2/MAP2K1/MAPK1/ARRB2/AKT1/PRKCA/GNAQ/PLCB2/ITPR1/KCNN4/PLCB3	-0.223611669725305
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/2128	28/9376	0.944146079484425	GCH1/MOCS2/PTS/AKR1B1/GPHN/DHFR	-0.160374636173301
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	22/2128	102/9376	0.95031696889282	ATP2A2/KCNMA1/RAB8A/RAP1A/ADCY7/ITPR2/ATP1A1/BST1/CA2/CD38/PRKCA/GNAQ/ATP1B1/PLCB2/SLC9A1/ITPR1/FXYD2/PLCB3/ATP2B1/RAP1B/RHOA/AMY2B	-0.273361268813357
Organismal Systems	Digestive system	hsa04970	Salivary secretion	20/2128	93/9376	0.94753011561161	KCNMA1/ADCY7/ITPR2/PRH1/ATP1A1/ADRB2/BST1/CD38/PRKCA/GNAQ/ATP1B1/PLCB2/SLC9A1/ITPR1/KCNN4/FXYD2/CALM1/PLCB3/ATP2B1/AMY2B	-0.275530553096727
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/2128	19/9376	0.927582113177681	DLAT/DLD/BCKDHB/AMT	-0.171205097463722
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/2128	38/9376	0.927582113177681	SGK1/NEDD4L/KRAS/ATP1A1/MAPK1/PRKCA/ATP1B1/FXYD2	-0.242366766602675
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/2128	144/9376	0.948517126148705	GRB2/ID2/ACVR1B/NRAS/RAF1/MAPK13/KRAS/SKIL/STAT3/JAK3/JARID2/MAP2K1/PCGF5/KLF4/SMAD4/FZD5/SMARCAD1/FZD2/DVL3/CTNNB1/MAPK1/AKT1/HESX1/GSK3B/ACVR1/PCGF3/SETDB1/RIF1/ID3/AXIN1/LIF	-0.337332735177919
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	65/2128	298/9376	0.961043548468487	IL18/CXCL8/IL6/CCL3L1/CCL20/IL2RA/CCL8/CCL3/TNF/IFNGR1/RELT/IFNGR2/IL1B/IL15RA/CCR1/CD40/CCL2/OSM/ACVR1B/TNFRSF9/IL10/IL10RA/IL1A/CCL4L2/TNFRSF10B/CXCL1/IL4R/TNFSF9/TNFRSF10A/IL1RAP/TNFSF15/LTBR/IL10RB/CSF3R/TGFBR2/FAS/IL27RA/CXCL3/TNFRSF10D/CSF1/CCR5/IFNAR2/TNFRSF14/CCL4/CXCL16/ACVR1/IL17RA/CCL18/IL13RA1/TNFSF13B/IL7/CXCL10/TNFSF12/CCL7/TNFSF13/IL6R/CCL23/IL23A/CXCL12/ACKR3/LIF/CXCL2/TNFSF8/IL3RA/IFNLR1	-0.3703009203645
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	51/2128	235/9376	0.956199008158695	ACSL1/PPARG/ACSL3/ACSL4/SDHD/ATF2/GRB2/ADCY7/NRAS/COA6/MAPK13/KRAS/MAP2K3/KDM1A/SMARCE1/SDHB/KDM3B/KDM3A/RHEB/SOS2/NDUFB5/SOS1/NDUFAF4/RPS6KA1/ARID1B/SIRT6/ACTL6A/NDUFB3/MT-ND6/COA1/COX19/UQCRC2/ACSL5/ATP5F1C/NDUFV2/TSC1/RPS6KB1/NDUFA9/AKT1S1/CREB5/RPTOR/UQCRH/MTOR/NDUFA7/NDUFAF7/MT-ND4L/PRKAG1/ATP5MGL/COX18/NDUFAF5/PRKAB2	-0.368454087874288
NA	NA	hsa03272	Virion - Hepatitis viruses	10/2128	48/9376	0.917919799498747	PDCD6IP/LAMP1/IST1/TSG101/CHMP7/LAMP2/CLDN23/OCLN/LDLR/CLDN15	-0.308906549427921
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/2128	48/9376	0.917919799498747	HK2/HK3/ATP1A1/AKT1/SLC2A5/ATP1B1/PLCB2/FXYD2/PLCB3/AMY2B	-0.308906549427921
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	50/2128	232/9376	0.949572206378014	VAV3/ACTR3/ITGAV/PDGFB/NRAS/RAF1/SSH2/KRAS/LIMK2/MAP2K1/ITGAX/CYFIP1/LPAR5/VAV1/PPP1CB/DIAPH2/PIP4K2A/PPP1CC/ITGAM/SOS2/PAK1/PIKFYVE/SSH1/SOS1/ACTR2/ARHGEF6/BRAF/MAPK1/AKT1/FGD3/GNA13/ACTN1/PIP4K2C/ARHGEF7/CDC42/ARPC1B/DIAPH1/LIMK1/SLC9A1/IQGAP3/TMSB4X/MSN/MYL12A/CXCL12/ARPC3/PPP1R12B/RHOA/LPAR2/ITGA10/ARPC5	-0.421413271083918
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/2128	15/9376	0.881203007518797	HEXA/SLC33A1/ST3GAL1	-0.249489521782812
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/2128	15/9376	0.881203007518797	TPK1/NTPCR/ACP1	-0.249489521782812
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/2128	78/9376	0.903797956429535	ACTR3/DNM2/CD2AP/ARHGAP10/ELMO2/HCLS1/ACTR2/CTNNB1/ELMO1/CTNNA1/CDC42/ARPC1B/ARPC3/CLTA/RHOA/ARPC5	-0.462273699759735
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/2128	212/9376	0.935239040998723	VAV3/LCP2/DOCK4/RAPGEF2/PDGFB/RAP1A/ADCY7/NRAS/APBB1IP/FPR1/GNAI3/RAF1/MAPK13/KRAS/MAP2K3/CTNND1/MAP2K1/LPAR5/PRKD3/VAV1/VASP/RAPGEF1/ITGAM/RALGDS/CSF1/CTNNB1/P2RY1/BRAF/MAPK1/AKT1/RASGRP3/CDC42/FARP2/PRKCA/GNAQ/PLCB2/SIPA1L3/RALA/CALM1/PLCB3/RAP1B/SIPA1L1/RHOA/LPAR2/RGS14	-0.516774433044372
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/2128	116/9376	0.911589318122893	SLC1A3/GLS/GLUL/GNB4/ADCY7/GNAI3/SLC38A2/GNG10/PPP3R1/ITPR2/HOMER3/PLA2G4A/PLA2G4C/GRK3/MAPK1/PPP3CC/PRKCA/GNG5/GNAQ/PLD1/GNGT2/PLCB2/ITPR1/PLCB3	-0.519147299300313
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/2128	21/9376	0.839240959541711	DSE/CSGALNACT2/B3GALT6/CHST12	-0.39960003208832
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/2128	98/9376	0.899186742366119	ATF2/CAMK2D/ADCY7/ITPR2/PRKD3/ATF1/ATP1A1/ATF6B/PRKCA/GNAQ/ATP1B1/PLCB2/ITPR1/CREB5/CALM1/DAGLA/PLCB3/ATP2B1/NR4A1/LDLR	-0.543582992286201
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/2128	41/9376	0.859710251237851	ALAS1/SDS/SDSL/DLD/SHMT1/SHMT2/GATM/AMT	-0.487778958836771
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/2128	205/9376	0.924188520080689	ATP2A2/PRKCD/SDHD/CAMK2D/GSR/PTEN/MAPK13/SP1/SDHB/NCF2/NFKB1/NCF4/NCF1/PPP1CB/PPP1CC/TGFBR2/NDUFB5/MPC2/VDAC1/AKT1/PDK3/NDUFB3/PPIF/MT-ND6/MPC1/SLC25A5/UQCRC2/GSK3B/ATP5F1C/NDUFV2/PRKCA/MAPK9/VDAC3/PDK4/PLCB2/CYBB/NDUFA9/UQCRH/MTOR/NDUFA7/MT-ND4L/PLCB3/CTSD	-0.594656151810286
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	50/2128	238/9376	0.92563341125924	TBK1/NF1/RGL1/GRB2/GNB4/ABL2/PDGFB/CHUK/RAP1A/NRAS/RAF1/GNG10/KRAS/SHOC2/ARF6/RAB5A/BCL2L1/MAP2K1/RASA2/NFKB1/RALGDS/SOS2/PAK1/PLA2G4A/SOS1/PLA2G4C/RAB5B/CSF1/MAPK1/AKT1/RASGRP3/RALGAPB/IKBKB/CDC42/ETS2/PRKCA/MAPK9/EXOC2/RASAL2/GNG5/PLD1/GNGT2/TGFA/RALA/CALM1/PLA1A/RAP1B/RALGAPA2/RHOA/REL	-0.629655671925383
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/2128	99/9376	0.890104047998785	FCGR2A/HLA-DQB1/FCGR2B/FPR3/FCGR3A/FCGR1A/PTAFR/ICAM1/IL10/FPR1/C1QC/HLA-DQA1/C3AR1/ITGAM/FPR2/C2/HLA-DQA2/DEFB1/FCAR/FCGR3B	-0.595604365452349
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/2128	42/9376	0.839240959541711	KMO/KYNU/ACAT2/ALDH3A2/CAT/DLD/ALDH2/EHHADH	-0.56575514209176
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2128	17/9376	0.777532065457762	CSAD/ADO/FMO4	-0.49743864011611
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/2128	101/9376	0.872478225266136	CAMK2D/ADCY7/NRAS/GNAI3/RAF1/KRAS/MAP2K1/FZD5/FZD2/DVL3/CTNNB1/MITF/MAPK1/GSK3B/EP300/PRKCA/GNAQ/PLCB2/CALM1/PLCB3	-0.698152718829352
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	40/2128	195/9376	0.903797956429535	CASP1/AQP9/FCGR2A/TLR2/TLR4/FPR3/CLEC7A/FCGR3A/FCGR1A/SIGLEC9/CASP4/FPR1/RAF1/MAPK13/CR1/MAP2K1/NCF2/NFKB1/NCF4/NCF1/ITGAM/MAP3K7/ATG7/VDAC1/MAPK1/AKT1/PPIF/SLC25A5/PRKCA/HDAC8/VDAC3/PLCB2/TLR8/CYBB/MTOR/FPR2/CLCN5/PLCB3/FCGR3B/AZU1	-0.735561461933052
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/2128	63/9376	0.839240959541711	POLK/FZD5/BAX/FZD2/DVL3/CTNNB1/GADD45A/GSK3B/CDKN1A/AXIN1/GADD45B/PTCH2	-0.693686489707753
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/2128	49/9376	0.809268068129508	COLGALT1/OGT/GALNT1/B4GALT1/GALNT12/GXYLT1/ST6GAL1/GALNT10/B3GLCT	-0.72529188268485
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/2128	44/9376	0.801093643198906	NSF/DCTN4/RAB5A/STX4/RAB5B/DCTN6/CREB5/DYNLL1	-0.716555763812773
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/2128	69/9376	0.830118775198867	ATF2/CAMK2D/PPP3R1/SIRT1/PPP1CB/PPP1CC/ATF6B/PPP3CC/PRKCA/JUN/FOS/CREB5/CALM1	-0.76740995662106
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/2128	65/9376	0.813418160786582	GK/GLA/ALDH3A2/LPIN2/AGPAT3/ALDH2/DGKG/AKR1B1/DGKD/AGK/DGKE/LPIN3	-0.817881231897772
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2128	46/9376	0.766263484798954	ALAS1/BLVRA/FTL/HMOX1/HCCS/CPOX/EARS2/MMAB	-0.861047314291812
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/2128	67/9376	0.789137021658624	HK2/ADPGK/HK3/MINPP1/DLAT/ALDOA/ALDH3A2/PGM2/DLD/ACSS2/ALDH2/FBP1	-0.938530909708264
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/2128	27/9376	0.652742968532442	HMGCS1/ACAT2/AACS/EHHADH	-0.979067666266749
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/2128	54/9376	0.734335839598997	CD80/HLA-DQB1/CD40/IL10/HLA-F/HLA-DQA1/FAS/CD86/HLA-DQA2	-1.06081012896689
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/2128	184/9376	0.838100686498856	PLXNC1/SRGAP2/NCK1/CAMK2D/NRAS/GNAI3/RAF1/SSH2/KRAS/PPP3R1/SEMA4A/SEMA4D/SEMA6B/LIMK2/NRP1/PAK1/SSH1/SRGAP1/MAPK1/PPP3CC/RYK/GSK3B/SEMA4B/CDC42/NCK2/PRKCA/LIMK1/PLXNA1/SEMA3C/MYL12A/CXCL12/LRIG2/PLXNA2/RHOA/L1CAM	-1.20174207985029
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/2128	86/9376	0.768490994929183	KCNMA1/ATF2/CAMK2D/ADCY7/ATP1A1/ATF6B/KCNMB1/PRKCA/GNAQ/ATP1B1/PLCB2/KCNN4/FXYD2/CREB5/PLCB3	-1.16861542615343
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/2128	157/9376	0.813849911402711	MOB1B/MOB1A/SAV1/TP53BP2/BIRC2/ID2/CCND1/PPP2R2A/LIMD1/YWHAG/SMAD4/FZD5/PPP1CB/LATS1/PPP1CC/TGFBR2/PPP2CA/FZD2/YWHAH/DVL3/CTNNB1/CTNNA1/CSNK1D/GSK3B/BBC3/PPP2R2D/SMAD7/AXIN1/BIRC3	-1.27448146445888
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/2128	134/9376	0.789137021658624	KCNMA1/PRKCD/ARHGEF11/ADCY7/RAF1/ITPR2/MAP2K1/PPP1CB/PPP1CC/PLA2G4A/PLA2G4C/BRAF/MAPK1/KCNMB1/GNA13/PTGIR/PRKCA/GNAQ/PLCB2/ITPR1/PPP1R12B/CALM1/PLCB3/RHOA	-1.33208553144043
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/2128	52/9376	0.677848467322152	ADCY7/ALOX5/HSD17B7/PTGS2/PLA2G4A/PLA2G4C/ACOT2/LDLR	-1.26218524506612
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	38/2128	203/9376	0.824771287825475	VAV3/GRB2/BIRC2/ITGAV/PDGFB/RAP1A/PARVG/CCND1/PTEN/RAF1/MAP2K1/VAV1/VASP/PPP1CB/PPP1CC/RAPGEF1/SOS2/PAK1/SOS1/CTNNB1/XIAP/BRAF/MAPK1/AKT1/GSK3B/ACTN1/CDC42/DIAPH1/PRKCA/MAPK9/JUN/MYL12A/BCL2/PPP1R12B/RAP1B/BIRC3/RHOA/ITGA10	-1.36760269846801
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/2128	36/9376	0.611946532999165	GALNT1/B4GALT5/GALNT12/ST3GAL1/GALNT10	-1.26395536563202
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/2128	97/9376	0.726765367025812	CAMK2D/GNB4/ADCY7/GNAI3/GNG10/MAPK1/PER1/PRKCA/GNG5/GNAQ/GNGT2/PLCB2/FOS/ITPR1/CALM1/PLCB3	-1.46566049967379
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/2128	138/9376	0.766263484798954	ATP6V1C1/SDHD/ATP6V1B2/CYCS/ATP6V1H/ATP6V0A1/ATP6V1D/SDHB/ATP6V1A/NDUFB5/NDUFB3/MT-ND6/UQCRC2/ATP5F1C/NDUFV2/ATP6V1G1/NDUFA9/UQCRH/ATP6V1E2/NDUFA7/MT-ND4L/ATP6V0D2/ATP5MGL/ATP6V1F	-1.49878551338519
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/2128	26/9376	0.508386350491614	ACOX1/PLA2G4A/PLA2G4C	-1.36008846912454
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	41/2128	226/9376	0.799321312129882	VAV3/ATP2A2/CAMK2D/RAP1A/ADCY7/SUCNR1/GNAI3/RAF1/NFKBIA/PDE4B/MAP2K1/ACOX1/VAV1/NFKB1/PPP1CB/PPP1CC/ATP1A1/PAK1/HCAR3/ADRB2/BRAF/MAPK1/AKT1/EP300/HCAR2/MAPK9/JUN/PTGER2/PLD1/ATP1B1/NFATC1/SLC9A1/FOS/FXYD2/CREB5/CALM1/FFAR2/ATP2B1/RAP1B/RHOA/ABCC4	-1.65465434078541
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/2128	90/9376	0.685380116959064	AQP9/ADCY7/ABCC3/NCEH1/ATP1A1/CA2/HMGCR/ATP1B1/SLC9A1/FXYD2/ABCB4/ABCG2/LDLR/ABCC4	-1.62500775540778
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/2128	63/9376	0.629430719656283	PTGES3/ALOX5/PTGS2/PTGR1/PLA2G4A/PLA2G4C/PTGS1/ALOX15B/LTA4H	-1.59903233150896
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/2128	59/9376	0.597425767809354	IDH1/GCLM/LAP3/GSR/SMS/RRM2B/ODC1/GSTO1	-1.68072356423557
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2128	29/9376	0.455794659061447	CALM1/PDE6A/PDE6G	-1.59033286885612
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/2128	82/9376	0.644782688428388	DPYD/TPMT/RRM2B/UPP1/HPRT1/CDADC1/GSTO1/NME7/UCKL1/CES1/NAT1/TYMP	-1.75049982961803
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/2128	36/9376	0.489557226399332	UGP2/RPE/AKR1B1/DHDH	-1.66259790829099
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/2128	49/9376	0.539512045419672	ATF2/GNAI3/NFKB1/ATF6B/JUN/CREB5	-1.75108683824395
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/2128	89/9376	0.643575230210357	GLS/GLUL/GNB4/ADCY7/NSF/GNAI3/SLC38A2/GNG10/PRKCA/GNG5/GNGT2/SLC6A12/GPHN	-1.83057495384472
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/2128	23/9376	0.383131742399477	FUT4/B4GALT1	-1.60488246400933
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2128	37/9376	0.476325950010161	COMT/FAH/FAHD1/GOT1	-1.72931490834671
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/2128	149/9376	0.709693697330575	GNB4/ADCY7/GNAI3/MAPK13/GNG10/ITPR2/PTGS2/NDUFB5/MAPK1/NDUFB3/MT-ND6/NDUFV2/PRKCA/MAPK9/GNG5/GNAQ/GNGT2/PLCB2/NDUFA9/ITPR1/NDUFA7/MT-ND4L/DAGLA/PLCB3	-1.93544884082909
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/2128	160/9376	0.715977443609023	CD80/HLA-DQB1/SDC4/CD40/ITGAV/ICAM1/SDC3/SDC2/HLA-F/CD58/HLA-DQA1/CD274/ITGAM/PDCD1LG2/CD226/SIGLEC1/CLDN23/ALCAM/CD86/PTPRC/OCLN/HLA-DQA2/L1CAM/SELL/CLDN15/CXADR	-1.96337812509417
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2128	16/9376	0.275375939849624	GOT1	-1.57179960293907
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/2128	91/9376	0.629430719656283	GNB4/ADCY7/GNAI3/GNG10/PDE7A/PDE4B/GRK3/PDE8A/ARRB2/PRKCA/GNG5/GNGT2/PDE1B	-1.92469320864844
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/2128	88/9376	0.60082023239918	PLAU/PLAUR/SERPINA1/CR1/C1QC/C3AR1/ITGAX/VSIG4/ITGAM/THBD/CD55/C2	-2.03850185680901
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/2128	59/9376	0.522747546833185	ADCY7/GNAI3/PTGS2/ABHD5/ADRB2/PTGS1/AKT1	-1.9925007116373
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/2128	87/9376	0.557082361075102	ATP2A2/SLC8A1/ATP1A1/UQCRC2/SLC9A6/ATP1B1/SLC9A1/FXYD2/UQCRH/SLC9A7/TPM3	-2.24884994852171
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2128	30/9376	0.293734335839599	PLA2G4A/PLA2G4C	-2.0993178078835
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	41/2128	254/9376	0.711207151737612	P2RX4/ATP2A2/MCOLN2/CAMK2D/PTAFR/PDGFB/ADCY7/SLC8A1/PPP3R1/HRH2/GNA15/ITPR2/P2RX7/PHKB/ADRB2/MCOLN1/ORAI3/MCOLN3/VDAC1/PPP3CC/PPIF/SLC25A5/CD38/MCU/PRKCA/VDAC3/GNAQ/PLCB2/NFATC1/TGFA/STIM2/ITPR1/CHRFAM7A/TFEB/PDE1B/CALM1/SPHK2/NTRK3/PLCB3/ATP2B1/CYSLTR1	-2.52825349393644
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/2128	31/9376	0.284259034683483	ALDH3A2/ALDH2	-2.16276546640848
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/2128	23/9376	0.191565871199738	PREP	-2.10327203682834
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/2128	183/9376	0.650067792431899	UTP18/NXF1/XPO1/XRN1/EFL1/RPP30/AK6/UTP6/BMS1/NXT2/WDR36/NMD3/RIOK2/GNL3/NOP10/RBM28/RAN/RPP25/NXT1/RIOK1/NAT10/NOB1/RPP38/UTP15/NOL6/RPP40/PWP2	-2.5902589861256
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/2128	194/9376	0.658631113867142	DYNLT1/CAPZA2/DYNLT3/DCTN4/KIFC3/MYO5A/MYO1E/MYO1G/CAPZA1/KIF1B/MYO5B/ACTR10/MYO7A/DCTN6/KIF13B/MYO1F/MYO9B/TUBA1B/MYO15B/MYL12A/DNAH3/CAPZB/TUBE1/KIFC2/TUBD1/DNAH14/STARD9/TPM3/DYNLL1	-2.60326580335125
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/2128	43/9376	0.307396397971673	ABCA1/ACAT2/SLC27A4	-2.46644081424935
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/2128	103/9376	0.513322140302212	SLC36A4/SLC8A1/SLC38A2/SLC7A7/SLC36A1/ATP1A1/SLC3A2/ATP1B1/COL8A2/KCNN4/FXYD2/SLC16A10	-2.69099214209038
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2128	26/9376	0.169462116830538	HHEX	-2.2977494607798
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	50/2128	323/9376	0.682045671454177	PLAU/GLS/MDM2/GRB2/MARCKS/ZEB2/MCL1/ST14/PDGFB/NRAS/CCND1/MDM4/PTEN/RAF1/KRAS/SIRT1/STAT3/SOCS1/CASP3/PTGS2/MAP2K1/CD44/EZH2/DNMT3A/DICER1/NFKB1/E2F3/HMOX1/ATM/SOS2/PIM1/SOS1/CDKN1B/ABCC1/MAPK1/EP300/SPRY2/NOTCH2/IKBKB/BMF/PRKCA/DDIT4/BCL2L2/CDKN1A/CCNG1/RPTOR/BCL2/MTOR/CDKN2A/RHOA	-3.15088171823522
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/2128	99/9376	0.445052023999392	IL6/ATP2A2/TNF/ITGAV/SLC8A1/SNTB1/PRKAG1/ITGA10/TPM3/PRKAB2	-3.00765798089863
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/2128	143/9376	0.523791997476208	FCGR2A/CD80/TNF/HLA-DQB1/FCGR3A/CD40/FCGR1A/IL10/C1QC/HLA-DQA1/TRIM21/SSB/ACTN1/CD86/C2/HLA-DQA2/FCGR3B	-3.10925003536423
NA	NA	hsa04082	Neuroactive ligand signaling	26/2128	199/9376	0.575660256168058	SLC1A3/P2RX4/OGFRL1/GNB4/ADCY7/GNAI3/GNG10/HRH2/OGFR/ADORA3/P2RY6/ADRB2/P2RY1/SLC17A9/ACHE/PRKCA/GNG5/P2RY13/GNAQ/GNGT2/PLCB2/CHRFAM7A/ADRA2B/SLC6A12/PLCB3/P2RY2	-3.27832676875699
NA	NA	hsa04518	Integrin signaling	18/2128	154/9376	0.514988770627868	ITGAV/ICAM1/PDGFB/PARVG/CCND1/FERMT3/ICAM4/ITGAX/ITGAM/CTNNB1/ARHGEF6/AKT1/GSK3B/ACTN1/CDC42/NCK2/MTOR/ITGA10	-3.28822822619248
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/2128	70/9376	0.314715359828142	PTGS2/GSTO1/SULT1A1/SULT1A3/NAT1	-3.11817762830009
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/2128	86/9376	0.358629130966952	PKD2L1/P2RY1/TAS2R30/PLCB2/PDE1B/PLCB3/TAS2R31	-3.23752370327098
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/2128	86/9376	0.358629130966952	ATP2A2/ITGAV/SLC8A1/SNTB1/CTNNB1/CTNNA1/ITGA10	-3.23752370327098
NA	NA	hsa04519	Cadherin signaling	62/2128	404/9376	0.676170624581255	FMN1/VAV3/MOB1B/MOB1A/SAV1/TAOK3/LHFPL2/ACTR3/PSEN1/CHUK/NRAS/RAF1/MAPK13/KRAS/MAP2K3/SHOC2/LIMD1/NFKBIA/CTNND1/MAP2K1/YWHAG/MYO1E/MYO1G/CYFIP1/FZD5/NCSTN/ERBIN/VAV1/NFKB1/SCN1B/VASP/PPP1CB/LATS1/PPP1CC/FZD2/YWHAH/DVL3/ACTR2/CTNNB1/CTNNA1/ADAM10/MAPK1/RYK/MYO7A/GSK3B/EP300/ACTN1/IKBKB/CDC42/ARPC1B/CSNK1A1/MYO1F/MAPK9/TMC6/TMC8/ARPC3/AXIN1/CDH23/RHOA/PCDHGA10/PRICKLE3/ARPC5	-3.60516088115608
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/2128	66/9376	0.267031214399635	HSD17B7/COMT/HSD17B12/RDH5	-3.23776232320933
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2128	41/9376	0.107463781404731	CHRFAM7A	-3.10329436948832
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/2128	105/9376	0.335696383816685	ATP2A2/TNF/ITGAV/ADCY7/SLC8A1/SNTB1/ITGA10/TPM3	-3.70902989032268
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/2128	191/9376	0.484430972719758	ATF2/GRB2/GNB4/NRAS/GNAI3/RAF1/GNG10/KRAS/MAP2K1/PPP1CB/PPP1CC/SOS2/SOS1/ATF6B/BRAF/MAPK1/HDAC8/GNG5/GNGT2/CREB5/CALM1	-3.90055387018591
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/2128	68/9376	0.194383016364441	RDH11/DHRS4/RDH5	-3.61257805937388
NA	NA	hsa04081	Hormone signaling	25/2128	219/9376	0.502969753149998	ITGAV/GNB4/ADCY7/ADIPOR1/GNAI3/GNG10/GNA15/STAT3/SMAD4/STAT5A/ADRB2/ADIPOR2/GNA13/ACVR1/GNG5/GNAQ/GNGT2/STK11/PLCB2/HAMP/ADRA2B/PLCB3/THRB/RHOA/SLC16A10	-4.03265089188234
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/2128	89/9376	0.247528934696291	CD47/SDC4/ITGAV/CD44/ITGA10	-3.86464354441691
Genetic Information Processing	Translation	hsa03010	Ribosome	24/2128	222/9376	0.476325950010161	MRPL18/DAP3/MRPL3/RPL22L1/MRPL44/MRPS35/MRPL47/MRPL19/MRPL34/MRPS25/MRPL42/MRPS31/RPS10/MRPL39/MRPS23/MRPL9/MRPS22/MRPL35/MRPL30/RPL36A/MRPS28/MRPL53/MRPS17/RPS27L	-4.27852864905354
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/2128	73/9376	0.120712740756	GSTO1/FMO4	-4.08642053119851
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	23/2128	233/9376	0.434928523024299	FMNL2/AMPD3/SDC4/ITGAV/CAPZA2/SDC3/SDC2/CAPZA1/LBR/SNTB1/TMOD3/DIAPH2/ATP1A1/FMNL3/DIAPH1/SYNE1/SPTAN1/ATP1B1/CAPZB/ITGA10/TPM3/LMNB1/ANK2	-4.732595041255
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/2128	79/9376	0.11154468449605	GSTO1/DHDH	-4.29674992311669
NA	NA	hsa04382	Cornified envelope formation	16/2128	217/9376	0.324867468209695	UGCG/ST14/S100A8/PPP2R2A/SPTLC1/ABHD5/PPP2CA/PPP2R3C/PPP2R5C/PPP2R2D/CLDN23/SLC27A4/OCLN/TCHH/S100A9/CLDN15	-5.45201736483145
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/2128	370/9376	0.35724446250762	P2RX4/OGFRL1/PTGER4/LPAR6/FPR3/PTAFR/FPR1/HRH2/OGFR/P2RX7/C3AR1/ADORA3/P2RY6/ADRB2/P2RY1/NR3C1/PTGIR/PTGER2/P2RY13/LTB4R/CHRFAM7A/ADRA2B/FPR2/NMB/THRB/CYSLTR1/LPAR2/CHRNA10/P2RY2/PAQR6	-6.83507170937403
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/2128	449/9376	0.0883165597735988	CAMK2D/SLC8A1/GRK3/ARRB2/PDE1B/SLC24A4/CALM1/RGS2/OR2B11	-10.7269640997647