ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0140098 catalytic activity, acting on RNA 155/4374 387/18639 0.400516795865633 1.70672897991302 1.68715737757578e-13 2.24391931217579e-10 GO:0030695 GTPase regulator activity 184/4374 489/18639 0.376278118609407 1.60344029555572 8.38277359771272e-13 4.59184497515749e-10 GO:0060589 nucleoside-triphosphatase regulator activity 184/4374 490/18639 0.375510204081633 1.60016796842194 1.03575450567462e-12 4.59184497515749e-10 GO:0019787 ubiquitin-like protein transferase activity 173/4374 479/18639 0.361169102296451 1.53905598941553 1.89946456324367e-10 6.07745911132914e-08 GO:0035091 phosphatidylinositol binding 114/4374 284/18639 0.401408450704225 1.71052860372109 2.28475906440945e-10 6.07745911132914e-08 GO:0031072 heat shock protein binding 63/4374 131/18639 0.480916030534351 2.04933559513712 5.99328258795483e-10 1.32851097366332e-07 GO:0005096 GTPase activator activity 108/4374 271/18639 0.398523985239852 1.69823698236982 1.0990182829631e-09 1.98525992064539e-07 GO:0016755 aminoacyltransferase activity 175/4374 496/18639 0.352822580645161 1.50348881587681 1.19414130565136e-09 1.98525992064539e-07 GO:0003712 transcription coregulator activity 173/4374 495/18639 0.349494949494949 1.48930872511119 3.32310587633812e-09 4.91081201725522e-07 GO:0016887 ATP hydrolysis activity 149/4374 417/18639 0.357314148681055 1.52262881053182 7.84836673691417e-09 1.04383277600958e-06 GO:0031267 small GTPase binding 109/4374 283/18639 0.385159010600707 1.64128459044046 8.71527926300971e-09 1.05375649270936e-06 GO:0051020 GTPase binding 118/4374 315/18639 0.374603174603175 1.59630282840159 1.4042237536362e-08 1.55634799361346e-06 GO:0004842 ubiquitin-protein transferase activity 157/4374 449/18639 0.349665924276169 1.49003730283117 1.6965580123093e-08 1.7357093510549e-06 GO:0016741 transferase activity, transferring one-carbon groups 87/4374 215/18639 0.404651162790698 1.7243468274476 1.91686382614001e-08 1.82102063483301e-06 GO:0016779 nucleotidyltransferase activity 60/4374 136/18639 0.441176470588235 1.87999273783587 8.33633023919871e-08 7.20274268185376e-06 GO:0019207 kinase regulator activity 107/4374 287/18639 0.372822299651568 1.58871395592263 8.66495360223009e-08 7.20274268185376e-06 GO:0043021 ribonucleoprotein complex binding 73/4374 177/18639 0.412429378531073 1.75749226941945 1.04644184092604e-07 8.18686852018607e-06 GO:0106310 protein serine kinase activity 128/4374 361/18639 0.354570637119114 1.51093783842322 1.44030484335669e-07 1.06422524536911e-05 GO:0008168 methyltransferase activity 81/4374 204/18639 0.397058823529412 1.69199346405229 1.53072487532278e-07 1.07150741272594e-05 GO:1901981 phosphatidylinositol phosphate binding 75/4374 185/18639 0.405405405405405 1.72756089422756 1.62563067500466e-07 1.0810443988781e-05 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 69/4374 167/18639 0.413173652694611 1.76066385747024 2.12891670304908e-07 1.2957440439194e-05 GO:0004674 protein serine/threonine kinase activity 148/4374 433/18639 0.341801385681293 1.45652401182296 2.14333601249826e-07 1.2957440439194e-05 GO:0140097 catalytic activity, acting on DNA 120/4374 336/18639 0.357142857142857 1.52189888300999 2.25461900306941e-07 1.30375794525318e-05 GO:0019887 protein kinase regulator activity 95/4374 255/18639 0.372549019607843 1.58754942306141 4.66115865140178e-07 2.58305875265182e-05 GO:0005085 guanyl-nucleotide exchange factor activity 87/4374 230/18639 0.378260869565217 1.61188942565754 6.6145008481003e-07 3.51891445118936e-05 GO:0044389 ubiquitin-like protein ligase binding 114/4374 322/18639 0.354037267080745 1.50866497967947 7.40055045767316e-07 3.78566619565588e-05 GO:0140662 ATP-dependent protein folding chaperone 24/4374 40/18639 0.6 2.55679012345679 8.12797599423397e-07 4.00378076753007e-05 GO:0003725 double-stranded RNA binding 37/4374 75/18639 0.493333333333333 2.10224965706447 9.15059080782168e-07 4.26822479093881e-05 GO:0061659 ubiquitin-like protein ligase activity 128/4374 372/18639 0.344086021505376 1.46625956900748 9.30665555918989e-07 4.26822479093881e-05 GO:0008234 cysteine-type peptidase activity 73/4374 187/18639 0.390374331550802 1.66350872560023 1.31172820914973e-06 5.81532839389712e-05 GO:0004197 cysteine-type endopeptidase activity 41/4374 88/18639 0.465909090909091 1.98538627010849 1.62906169560813e-06 6.93098699524484e-05 GO:0043022 ribosome binding 49/4374 112/18639 0.4375 1.86432613168724 1.66760589359274e-06 6.93098699524484e-05 GO:0140857 histone H3T45 kinase activity 90/4374 246/18639 0.365853658536585 1.55901836796146 2.24402253867878e-06 8.62010076731673e-05 GO:0005543 phospholipid binding 161/4374 497/18639 0.323943661971831 1.38042659247667 2.71209816932814e-06 8.62010076731673e-05 GO:0035403 histone H3T6 kinase activity 90/4374 247/18639 0.364372469635628 1.55270655270655 2.7261163646982e-06 8.62010076731673e-05 GO:0031625 ubiquitin protein ligase binding 106/4374 302/18639 0.350993377483444 1.49569400158068 2.80915004281607e-06 8.62010076731673e-05 GO:0004860 protein kinase inhibitor activity 39/4374 84/18639 0.464285714285714 1.97846854791299 3.22675009789765e-06 8.62010076731673e-05 GO:0004679 AMP-activated protein kinase activity 90/4374 248/18639 0.362903225806452 1.54644563918757 3.30422296624691e-06 8.62010076731673e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0004711 ribosomal protein S6 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0035175 histone H3S10 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0035979 histone H2AXS139 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0044022 histone H3S28 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0044023 histone H4S1 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0044024 histone H2AS1 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0044025 histone H2BS14 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0072354 histone H3T3 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0072371 histone H2AS121 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0140823 histone H2BS36 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0140855 histone H3S57 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0140995 histone H2A kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0140997 histone H4 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0140998 histone H2B kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:1990244 histone H2AT120 kinase activity 89/4374 245/18639 0.363265306122449 1.54798857814731 3.56470332483022e-06 8.62010076731673e-05 GO:0061791 GTPase motor activity 23/4374 40/18639 0.575 2.45025720164609 3.85292194329868e-06 8.99015120103025e-05 GO:1990606 membrane scission GTPase motor activity 23/4374 40/18639 0.575 2.45025720164609 3.85292194329868e-06 8.99015120103025e-05 GO:0004677 DNA-dependent protein kinase activity 89/4374 246/18639 0.361788617886179 1.54169594165077 4.31336950296701e-06 9.89100248094158e-05 GO:0004518 nuclease activity 78/4374 209/18639 0.373205741626794 1.59034792368126 4.41439037607503e-06 9.95108339013525e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 88/4374 243/18639 0.362139917695473 1.5431929414554 4.65550430954508e-06 0.000103197012194916 GO:0030544 Hsp70 protein binding 27/4374 51/18639 0.529411764705882 2.25599128540305 4.8982023048404e-06 0.000106796869925209 GO:0035402 histone H3T11 kinase activity 89/4374 247/18639 0.360323886639676 1.53545425767648 5.20745513148562e-06 0.000111708311691546 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 30/4374 60/18639 0.5 2.13065843621399 6.82845249655439e-06 0.000144156219371704 GO:0140101 catalytic activity, acting on a tRNA 56/4374 139/18639 0.402877697841727 1.71678953133789 7.14185749544925e-06 0.000148416726077305 GO:0140674 ATP-dependent histone chaperone activity 60/4374 152/18639 0.394736842105263 1.6820987654321 7.36769455087771e-06 0.000150754365425652 GO:0019210 kinase inhibitor activity 40/4374 90/18639 0.444444444444444 1.89391860996799 9.16799444066278e-06 0.00018243063189496 GO:0004527 exonuclease activity 38/4374 84/18639 0.452380952380952 1.92773858514599 9.1901145390694e-06 0.00018243063189496 GO:0004540 RNA nuclease activity 50/4374 121/18639 0.413223140495868 1.76087474067272 9.45726244175461e-06 0.000184972927169612 GO:0000287 magnesium ion binding 83/4374 230/18639 0.360869565217391 1.53777956700662 9.9657774301817e-06 0.000192093970755676 GO:0051087 protein-folding chaperone binding 54/4374 134/18639 0.402985074626866 1.71724709784411 1.0225690032653e-05 0.000194288110620406 GO:0008094 ATP-dependent activity, acting on DNA 77/4374 210/18639 0.366666666666667 1.56248285322359 1.06771541085773e-05 0.000200008661470533 GO:0005525 GTP binding 125/4374 378/18639 0.330687830687831 1.40916563241666 1.15738884619148e-05 0.000213795439643705 GO:0140713 histone chaperone activity 63/4374 164/18639 0.384146341463415 1.63696928635953 1.23585905293607e-05 0.000218100426446041 GO:0000510 H3-H4 histone complex chaperone activity 59/4374 151/18639 0.390728476821192 1.66501785081623 1.26268667942445e-05 0.000218100426446041 GO:0140584 chromatin extrusion motor activity 59/4374 151/18639 0.390728476821192 1.66501785081623 1.26268667942445e-05 0.000218100426446041 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 59/4374 151/18639 0.390728476821192 1.66501785081623 1.26268667942445e-05 0.000218100426446041 GO:0140849 ATP-dependent H2AZ histone chaperone activity 59/4374 151/18639 0.390728476821192 1.66501785081623 1.26268667942445e-05 0.000218100426446041 GO:0015616 DNA translocase activity 59/4374 152/18639 0.388157894736842 1.65406378600823 1.59633309056278e-05 0.000272195257749807 GO:0004532 RNA exonuclease activity 22/4374 40/18639 0.55 2.34372427983539 1.65707133544672e-05 0.000278975300777738 GO:1905394 retromer complex binding 9/4374 10/18639 0.9 3.83518518518519 1.69245257339887e-05 0.000281370240327562 GO:0003924 GTPase activity 111/4374 331/18639 0.335347432024169 1.42902167020999 1.76676530314761e-05 0.000286733456098049 GO:0003727 single-stranded RNA binding 39/4374 89/18639 0.438202247191011 1.86731862949091 1.76783033083007e-05 0.000286733456098049 GO:0061775 cohesin loader activity 59/4374 153/18639 0.38562091503268 1.64325291158988 2.00992010494273e-05 0.000322071534888414 GO:0003689 DNA clamp loader activity 61/4374 160/18639 0.38125 1.62462705761317 2.20606136746509e-05 0.00034929304984864 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 21/4374 38/18639 0.552631578947368 2.35493827160494 2.33704470982316e-05 0.000365678760478213 GO:0044183 protein folding chaperone 34/4374 75/18639 0.453333333333333 1.93179698216735 2.52978139381665e-05 0.000391233634160017 GO:0140658 ATP-dependent chromatin remodeler activity 60/4374 158/18639 0.379746835443038 1.61822159712455 2.94176416791544e-05 0.000449717970497418 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 115/4374 349/18639 0.329512893982808 1.40415885481151 3.02820563719499e-05 0.000457671988348788 GO:0008173 RNA methyltransferase activity 31/4374 67/18639 0.462686567164179 1.9716540753025 3.48150102736205e-05 0.000520269254650734 GO:0032182 ubiquitin-like protein binding 48/4374 120/18639 0.4 1.70452674897119 3.88370025841609e-05 0.000573924593743711 GO:0019783 ubiquitin-like protein peptidase activity 50/4374 127/18639 0.393700787401575 1.67768380804251 4.43984814794881e-05 0.000648900883161749 GO:0070063 RNA polymerase binding 28/4374 59/18639 0.474576271186441 2.02231987166074 4.66403333311349e-05 0.000674256992721841 GO:0051082 unfolded protein binding 48/4374 121/18639 0.396694214876033 1.69043975104581 4.98591817022428e-05 0.000713039910365407 GO:0140297 DNA-binding transcription factor binding 152/4374 488/18639 0.311475409836066 1.32729541928085 5.08703217208215e-05 0.000719760934986091 GO:0061630 ubiquitin protein ligase activity 115/4374 353/18639 0.325779036827195 1.38824770631507 5.24945345382048e-05 0.000734923483534867 GO:0140597 protein carrier chaperone 68/4374 188/18639 0.361702127659574 1.54132737938885 5.56799789786572e-05 0.000766997453622334 GO:0032266 phosphatidylinositol-3-phosphate binding 24/4374 48/18639 0.5 2.13065843621399 5.59389120311025e-05 0.000766997453622334 GO:0140463 chromatin-protein adaptor activity 26/4374 54/18639 0.481481481481481 2.05174516079866 6.34233512559328e-05 0.000860745481330516 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 21/4374 40/18639 0.525 2.23719135802469 6.47672170744455e-05 0.000870105037464774 GO:0002039 p53 binding 31/4374 69/18639 0.449275362318841 1.91450468181547 7.01018890804681e-05 0.000932355124770226 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 16/4374 27/18639 0.592592592592593 2.52522481329066 7.10835570903997e-05 0.000936050801289421 GO:0032404 mismatch repair complex binding 9/4374 11/18639 0.818181818181818 3.48653198653199 7.35081728402789e-05 0.000958488920368342 GO:0140104 molecular carrier activity 85/4374 249/18639 0.34136546184739 1.45466640223445 8.05978570744701e-05 0.0010242239101316 GO:0019001 guanyl nucleotide binding 127/4374 400/18639 0.3175 1.35296810699588 8.1221032223867e-05 0.0010242239101316 GO:0032561 guanyl ribonucleotide binding 127/4374 400/18639 0.3175 1.35296810699588 8.1221032223867e-05 0.0010242239101316 GO:0140030 modification-dependent protein binding 63/4374 173/18639 0.364161849710983 1.55180903446799 8.16298755443231e-05 0.0010242239101316 GO:0043539 protein serine/threonine kinase activator activity 32/4374 73/18639 0.438356164383562 1.86797451942049 9.65025416227733e-05 0.00119951757344195 GO:0017056 structural constituent of nuclear pore 15/4374 25/18639 0.6 2.55679012345679 9.85505125901839e-05 0.00121363131245319 GO:0000993 RNA polymerase II complex binding 19/4374 36/18639 0.527777777777778 2.24902834933699 0.000131133533834012 0.00158552363635668 GO:0005484 SNAP receptor activity 19/4374 36/18639 0.527777777777778 2.24902834933699 0.000131133533834012 0.00158552363635668 GO:0043175 RNA polymerase core enzyme binding 21/4374 42/18639 0.5 2.13065843621399 0.000161494811042834 0.00193502791609883 GO:0043130 ubiquitin binding 40/4374 100/18639 0.4 1.70452674897119 0.000165278836747425 0.00196268618637567 GO:0019003 GDP binding 32/4374 75/18639 0.426666666666667 1.81816186556927 0.000179009156207798 0.00210692192704753 GO:0061665 SUMO ligase activity 10/4374 14/18639 0.714285714285714 3.04379776601999 0.000193708945582077 0.00225993769845756 GO:0035173 histone kinase activity 114/4374 360/18639 0.316666666666667 1.34941700960219 0.000205235237772645 0.00235716099293056 GO:0016791 phosphatase activity 90/4374 273/18639 0.32967032967033 1.40482973816307 0.000205586973819508 0.00235716099293056 GO:0008170 N-methyltransferase activity 39/4374 98/18639 0.397959183673469 1.69583018392542 0.000224884295754713 0.0025563770372117 GO:0003713 transcription coactivator activity 85/4374 256/18639 0.33203125 1.41489036779835 0.000233291445254536 0.00262947137447909 GO:0008408 3'-5' exonuclease activity 26/4374 58/18639 0.448275862068966 1.91024549453668 0.000274585852623594 0.00306890070579311 GO:0000175 3'-5'-RNA exonuclease activity 18/4374 35/18639 0.514285714285714 2.19153439153439 0.000300620418088891 0.0033318763004852 GO:0000049 tRNA binding 33/4374 80/18639 0.4125 1.75779320987654 0.000306030881110647 0.00336381051138149 GO:0140996 histone H3 kinase activity 112/4374 357/18639 0.313725490196078 1.33688372468329 0.000345142529419029 0.00376261937809269 GO:0030145 manganese ion binding 29/4374 68/18639 0.426470588235294 1.81732631324135 0.000356633931182976 0.00384948546841526 GO:0140517 protein-RNA adaptor activity 13/4374 22/18639 0.590909090909091 2.51805087916199 0.000358899397055257 0.00384948546841526 GO:0141003 histone H2AX kinase activity 111/4374 354/18639 0.313559322033898 1.33617562949013 0.000373929117715491 0.00397860581249282 GO:0140311 protein sequestering activity 17/4374 33/18639 0.515151515151515 2.19522384337199 0.000429806470447846 0.00453684607694949 GO:0019902 phosphatase binding 65/4374 190/18639 0.342105263157895 1.45781893004115 0.000488860732008446 0.00511956514623018 GO:0008276 protein methyltransferase activity 37/4374 95/18639 0.389473684210526 1.659670781893 0.000527470145657926 0.00548074448222688 GO:0019789 SUMO transferase activity 15/4374 28/18639 0.535714285714286 2.28284832451499 0.000543043805086907 0.0055850044187588 GO:0101005 deubiquitinase activity 43/4374 115/18639 0.373913043478261 1.59336196099481 0.000545902687547852 0.0055850044187588 GO:0016278 lysine N-methyltransferase activity 29/4374 70/18639 0.414285714285714 1.76540270429159 0.000635955386657135 0.00645664629201519 GO:0008175 tRNA methyltransferase activity 17/4374 34/18639 0.5 2.13065843621399 0.000672805813703172 0.00672805813703172 GO:0052866 phosphatidylinositol phosphate phosphatase activity 17/4374 34/18639 0.5 2.13065843621399 0.000672805813703172 0.00672805813703172 GO:0140313 molecular sequestering activity 24/4374 55/18639 0.436363636363636 1.85948372615039 0.000752433167734018 0.00746817994840481 GO:0016922 nuclear receptor binding 49/4374 137/18639 0.357664233576642 1.52412063320417 0.00076119495123298 0.00749917988992491 GO:0060590 ATPase regulator activity 22/4374 49/18639 0.448979591836735 1.91324431006971 0.000772802113900763 0.00755755008447069 GO:0019209 kinase activator activity 52/4374 148/18639 0.351351351351351 1.49721944166389 0.00085858562936388 0.0083351743580581 GO:0003697 single-stranded DNA binding 44/4374 121/18639 0.363636363636364 1.54956977179199 0.000932905174843962 0.00899104262711935 GO:0051059 NF-kappaB binding 16/4374 32/18639 0.5 2.13065843621399 0.000964254982208488 0.00917161087196328 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 10/4374 16/18639 0.625 2.66332304526749 0.000965432723364556 0.00917161087196328 GO:0031593 polyubiquitin modification-dependent protein binding 25/4374 59/18639 0.423728813559322 1.80564274255423 0.000993877667433704 0.00937487445167962 GO:0043015 gamma-tubulin binding 17/4374 35/18639 0.485714285714286 2.06978248089359 0.00102431424289444 0.00952683876258464 GO:0140566 histone reader activity 17/4374 35/18639 0.485714285714286 2.06978248089359 0.00102431424289444 0.00952683876258464 GO:0004843 cysteine-type deubiquitinase activity 40/4374 108/18639 0.37037037037037 1.57826550830666 0.0010365333190215 0.00957353690485139 GO:0016279 protein-lysine N-methyltransferase activity 28/4374 69/18639 0.405797101449275 1.72923003518817 0.0011507884851523 0.0105555081741556 GO:0140036 ubiquitin-modified protein reader activity 11/4374 19/18639 0.578947368421053 2.46707818930041 0.00130674889631808 0.0119039454253633 GO:0015215 nucleotide transmembrane transporter activity 15/4374 30/18639 0.5 2.13065843621399 0.00138414655168001 0.0124390875890827 GO:0003714 transcription corepressor activity 67/4374 204/18639 0.32843137254902 1.39955014927782 0.00138419922043927 0.0124390875890827 GO:0003925 G protein activity 23/4374 54/18639 0.425925925925926 1.81500533455266 0.00143449941552759 0.0128045920983335 GO:0016830 carbon-carbon lyase activity 22/4374 51/18639 0.431372549019608 1.83821512143952 0.00147926752413771 0.0131161720473544 GO:0042578 phosphoric ester hydrolase activity 110/4374 363/18639 0.303030303030303 1.29130814315999 0.00151311230754223 0.0132629007505131 GO:0140693 molecular condensate scaffold activity 21/4374 48/18639 0.4375 1.86432613168724 0.00151576008577292 0.0132629007505131 GO:0046915 transition metal ion transmembrane transporter activity 20/4374 45/18639 0.444444444444444 1.89391860996799 0.00154138322865215 0.0133989522490677 GO:0004386 helicase activity 53/4374 155/18639 0.341935483870968 1.45709544670118 0.00155546590183827 0.0134335691522396 GO:0042054 histone methyltransferase activity 27/4374 67/18639 0.402985074626866 1.71724709784411 0.00158060240570577 0.013562588384443 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 12/4374 22/18639 0.545454545454545 2.32435465768799 0.00159509601050548 0.0135992159870018 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 8/4374 12/18639 0.666666666666667 2.84087791495199 0.00178913728485717 0.015156385916306 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 45/4374 128/18639 0.3515625 1.49811921296296 0.00181677477128471 0.0152931040873966 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 10/4374 17/18639 0.588235294117647 2.50665698378117 0.00185257025661634 0.0153994902581234 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 10/4374 17/18639 0.588235294117647 2.50665698378117 0.00185257025661634 0.0153994902581234 GO:0141052 histone H3 demethylase activity 14/4374 28/18639 0.5 2.13065843621399 0.0019904640897242 0.0164343828789253 GO:0030295 protein kinase activator activity 48/4374 139/18639 0.345323741007194 1.47153388400391 0.00200178197472624 0.0164343828789253 GO:0004721 phosphoprotein phosphatase activity 58/4374 175/18639 0.331428571428571 1.41232216343327 0.00220819293865816 0.0180177706037752 GO:0016505 peptidase activator activity involved in apoptotic process 11/4374 20/18639 0.55 2.34372427983539 0.0022909775121412 0.0185792688484622 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/4374 10/18639 0.7 2.98292181069959 0.00236113435992871 0.0189175222813566 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 7/4374 10/18639 0.7 2.98292181069959 0.00236113435992871 0.0189175222813566 GO:0019903 protein phosphatase binding 49/4374 144/18639 0.340277777777778 1.45003143575674 0.002556519272485 0.0203603031880542 GO:0140776 protein-containing complex destabilizing activity 9/4374 15/18639 0.6 2.55679012345679 0.0026213338684424 0.0207522264585023 GO:0016853 isomerase activity 59/4374 180/18639 0.327777777777778 1.39676497485139 0.00270606899651572 0.0212962826353012 GO:0032813 tumor necrosis factor receptor superfamily binding 21/4374 50/18639 0.42 1.78975308641975 0.00279402409290642 0.0218591296680326 GO:0043014 alpha-tubulin binding 19/4374 44/18639 0.431818181818182 1.84011410400299 0.00299948320725504 0.0233293138342059 GO:0042887 amide transmembrane transporter activity 17/4374 38/18639 0.447368421052632 1.90637860082305 0.0031259222181453 0.0241713752914724 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 10/4374 18/18639 0.555555555555556 2.36739826245999 0.00329595521885704 0.0253388464802304 GO:0016504 peptidase activator activity 23/4374 57/18639 0.403508771929825 1.71947873799726 0.0033398483493785 0.0255287258889276 GO:0140767 enzyme-substrate adaptor activity 47/4374 139/18639 0.338129496402878 1.44087692808716 0.00354957071350618 0.026976737422647 GO:0035673 oligopeptide transmembrane transporter activity 8/4374 13/18639 0.615384615384615 2.62234884457107 0.00369614312624931 0.0274629628933608 GO:0046975 histone H3K36 methyltransferase activity 8/4374 13/18639 0.615384615384615 2.62234884457107 0.00369614312624931 0.0274629628933608 GO:0051011 microtubule minus-end binding 8/4374 13/18639 0.615384615384615 2.62234884457107 0.00369614312624931 0.0274629628933608 GO:0140852 histone ubiquitin ligase activity 8/4374 13/18639 0.615384615384615 2.62234884457107 0.00369614312624931 0.0274629628933608 GO:0038187 pattern recognition receptor activity 20/4374 48/18639 0.416666666666667 1.77554869684499 0.00389500876315155 0.0286624321699157 GO:0035591 signaling adaptor activity 44/4374 129/18639 0.341085271317829 1.45347242160334 0.00390067685921409 0.0286624321699157 GO:0004725 protein tyrosine phosphatase activity 35/4374 98/18639 0.357142857142857 1.52189888300999 0.00413188533159287 0.0301111360973517 GO:0035035 histone acetyltransferase binding 12/4374 24/18639 0.5 2.13065843621399 0.00414311120737998 0.0301111360973517 GO:0051879 Hsp90 protein binding 18/4374 42/18639 0.428571428571429 1.82627865961199 0.00421798182454224 0.030488672970876 GO:0061980 regulatory RNA binding 23/4374 58/18639 0.396551724137931 1.68983255285937 0.0043243567158017 0.0310886185514392 GO:0032452 histone demethylase activity 14/4374 30/18639 0.466666666666667 1.98861454046639 0.00446057478080009 0.031895507841205 GO:0015923 mannosidase activity 9/4374 16/18639 0.5625 2.39699074074074 0.00475034962639962 0.0337859091075481 GO:0000149 SNARE binding 37/4374 106/18639 0.349056603773585 1.48744079509279 0.00503265159874441 0.0356033331187769 GO:0008186 ATP-dependent activity, acting on RNA 29/4374 79/18639 0.367088607594937 1.5642808772204 0.00551918740466996 0.0388387261810108 GO:0140035 ubiquitin-like protein reader activity 11/4374 22/18639 0.5 2.13065843621399 0.00600123425351581 0.0420086397746106 GO:0008135 translation factor activity, RNA binding 30/4374 83/18639 0.36144578313253 1.5402350141306 0.00622286932938884 0.043211565728268 GO:0004709 MAP kinase kinase kinase activity 12/4374 25/18639 0.48 2.04543209876543 0.00628522107327028 0.043211565728268 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 12/4374 25/18639 0.48 2.04543209876543 0.00628522107327028 0.043211565728268 GO:0090482 vitamin transmembrane transporter activity 15/4374 34/18639 0.441176470588235 1.87999273783587 0.00630374714644702 0.043211565728268 GO:0070273 phosphatidylinositol-4-phosphate binding 14/4374 31/18639 0.451612903225806 1.92446568432232 0.00640051011163068 0.043211565728268 GO:0072349 modified amino acid transmembrane transporter activity 14/4374 31/18639 0.451612903225806 1.92446568432232 0.00640051011163068 0.043211565728268 GO:0140457 protein demethylase activity 14/4374 31/18639 0.451612903225806 1.92446568432232 0.00640051011163068 0.043211565728268 GO:0015605 organophosphate ester transmembrane transporter activity 20/4374 50/18639 0.4 1.70452674897119 0.0067232861277684 0.0451614674238989 GO:0008174 mRNA methyltransferase activity 8/4374 14/18639 0.571428571428571 2.43503821281599 0.00685946986376028 0.045163836231689 GO:0008474 palmitoyl-(protein) hydrolase activity 8/4374 14/18639 0.571428571428571 2.43503821281599 0.00685946986376028 0.045163836231689 GO:0019763 immunoglobulin receptor activity 8/4374 14/18639 0.571428571428571 2.43503821281599 0.00685946986376028 0.045163836231689 GO:0098599 palmitoyl hydrolase activity 8/4374 14/18639 0.571428571428571 2.43503821281599 0.00685946986376028 0.045163836231689 GO:0001098 basal transcription machinery binding 23/4374 60/18639 0.383333333333333 1.63350480109739 0.00702249420367316 0.0455928088005298 GO:0001099 basal RNA polymerase II transcription machinery binding 23/4374 60/18639 0.383333333333333 1.63350480109739 0.00702249420367316 0.0455928088005298 GO:0001221 transcription coregulator binding 39/4374 115/18639 0.339130434782609 1.44514224369297 0.00702746301060798 0.0455928088005298 GO:0140938 histone H3 methyltransferase activity 19/4374 47/18639 0.404255319148936 1.72266001225812 0.00713585868850935 0.0460713206588225 GO:0003724 RNA helicase activity 28/4374 77/18639 0.363636363636364 1.54956977179199 0.00732474181702449 0.0469084508983717 GO:0042393 histone binding 75/4374 247/18639 0.303643724696356 1.29392212725546 0.00733605848636189 0.0469084508983717 GO:0180051 translation factor activity 30/4374 84/18639 0.357142857142857 1.52189888300999 0.00754789672612352 0.0480320700753315 GO:0003684 damaged DNA binding 27/4374 74/18639 0.364864864864865 1.5548048048048 0.00794468470943215 0.0497839597436904 GO:0042169 SH2 domain binding 17/4374 41/18639 0.414634146341463 1.76688748368965 0.00795096632580056 0.0497839597436904 GO:0061650 ubiquitin-like protein conjugating enzyme activity 17/4374 41/18639 0.414634146341463 1.76688748368965 0.00795096632580056 0.0497839597436904 GO:0051787 misfolded protein binding 9/4374 17/18639 0.529411764705882 2.25599128540305 0.00801035141740583 0.0497839597436904 GO:1990226 histone methyltransferase binding 9/4374 17/18639 0.529411764705882 2.25599128540305 0.00801035141740583 0.0497839597436904 GO:0061631 ubiquitin conjugating enzyme activity 15/4374 35/18639 0.428571428571429 1.82627865961199 0.00867569784757035 0.0532084889391658 GO:0000339 RNA cap binding 10/4374 20/18639 0.5 2.13065843621399 0.00872139142010386 0.0532084889391658 GO:0030742 GTP-dependent protein binding 10/4374 20/18639 0.5 2.13065843621399 0.00872139142010386 0.0532084889391658 GO:0043024 ribosomal small subunit binding 10/4374 20/18639 0.5 2.13065843621399 0.00872139142010386 0.0532084889391658 GO:0070717 poly-purine tract binding 14/4374 32/18639 0.4375 1.86432613168724 0.00895868746785709 0.0538557504260006 GO:0140142 nucleocytoplasmic carrier activity 14/4374 32/18639 0.4375 1.86432613168724 0.00895868746785709 0.0538557504260006 GO:0003887 DNA-directed DNA polymerase activity 11/4374 23/18639 0.478260869565217 2.03802111290034 0.00909364101290491 0.0538557504260006 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 11/4374 23/18639 0.478260869565217 2.03802111290034 0.00909364101290491 0.0538557504260006 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 11/4374 23/18639 0.478260869565217 2.03802111290034 0.00909364101290491 0.0538557504260006 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 13/4374 29/18639 0.448275862068966 1.91024549453668 0.00915142826787679 0.0538557504260006 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 13/4374 29/18639 0.448275862068966 1.91024549453668 0.00915142826787679 0.0538557504260006 GO:0097472 cyclin-dependent protein kinase activity 13/4374 29/18639 0.448275862068966 1.91024549453668 0.00915142826787679 0.0538557504260006 GO:1990841 promoter-specific chromatin binding 25/4374 68/18639 0.367647058823529 1.56666061486323 0.00933957473079687 0.054720856352246 GO:0019208 phosphatase regulator activity 39/4374 117/18639 0.333333333333333 1.42043895747599 0.00961460527590448 0.0559551904955614 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 29/4374 82/18639 0.353658536585366 1.50705108902941 0.00990445667444866 0.0559551904955614 GO:0000340 RNA 7-methylguanosine cap binding 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:0004875 complement receptor activity 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:0016423 tRNA (guanine) methyltransferase activity 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:0097677 STAT family protein binding 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:1990247 N6-methyladenosine-containing RNA reader activity 7/4374 12/18639 0.583333333333333 2.48576817558299 0.0099232792146972 0.0559551904955614 GO:0004722 protein serine/threonine phosphatase activity 35/4374 103/18639 0.339805825242718 1.44802029645611 0.00992889094507706 0.0559551904955614 GO:0035198 miRNA binding 17/4374 42/18639 0.404761904761905 1.72481873407799 0.0104893957866563 0.0588645417563411 GO:0019888 protein phosphatase regulator activity 36/4374 107/18639 0.336448598130841 1.4337140879197 0.0106854262663903 0.0597126761945339 GO:0004559 alpha-mannosidase activity 8/4374 15/18639 0.533333333333333 2.27270233196159 0.0117030538584093 0.0647985986960367 GO:0050700 CARD domain binding 8/4374 15/18639 0.533333333333333 2.27270233196159 0.0117030538584093 0.0647985986960367 GO:0051536 iron-sulfur cluster binding 27/4374 76/18639 0.355263157894737 1.51388888888889 0.0117417009667254 0.0647985986960367 GO:0016763 pentosyltransferase activity 19/4374 49/18639 0.387755102040816 1.65234735869656 0.0118606496240954 0.0650310091645987 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 29/4374 83/18639 0.349397590361446 1.48889384699291 0.0118816054338327 0.0650310091645987 GO:0017124 SH3 domain binding 38/4374 115/18639 0.330434782608696 1.40808731436751 0.0121943463728874 0.0664691830981157 GO:0000900 mRNA regulatory element binding translation repressor activity 9/4374 18/18639 0.5 2.13065843621399 0.0127247476159546 0.0677690941007652 GO:0004706 JUN kinase kinase kinase activity 9/4374 18/18639 0.5 2.13065843621399 0.0127247476159546 0.0677690941007652 GO:0008409 5'-3' exonuclease activity 9/4374 18/18639 0.5 2.13065843621399 0.0127247476159546 0.0677690941007652 GO:0030291 protein serine/threonine kinase inhibitor activity 18/4374 46/18639 0.391304347826087 1.66747181964573 0.0127276750847384 0.0677690941007652 GO:0008187 poly-pyrimidine tract binding 13/4374 30/18639 0.433333333333333 1.84657064471879 0.0127385515227002 0.0677690941007652 GO:0070566 adenylyltransferase activity 13/4374 30/18639 0.433333333333333 1.84657064471879 0.0127385515227002 0.0677690941007652 GO:0001671 ATPase activator activity 12/4374 27/18639 0.444444444444444 1.89391860996799 0.0131008994149923 0.0691436358013484 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 12/4374 27/18639 0.444444444444444 1.89391860996799 0.0131008994149923 0.0691436358013484 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 10/4374 21/18639 0.476190476190476 2.02919851067999 0.0131970516820068 0.0693758052848579 GO:0004712 protein serine/threonine/tyrosine kinase activity 17/4374 43/18639 0.395348837209302 1.68470667049478 0.0136292402858695 0.0713657070086866 GO:0051540 metal cluster binding 27/4374 77/18639 0.350649350649351 1.49422799422799 0.014126858907564 0.0732102777017491 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0005381 iron ion transmembrane transporter activity 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0016427 tRNA (cytidine) methyltransferase activity 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0031996 thioesterase binding 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0099122 RNA polymerase II C-terminal domain binding 6/4374 10/18639 0.6 2.55679012345679 0.0143762795048627 0.0732102777017491 GO:0004519 endonuclease activity 41/4374 127/18639 0.322834645669291 1.37570072259486 0.0144218742540288 0.0732102777017491 GO:0030331 nuclear estrogen receptor binding 16/4374 40/18639 0.4 1.70452674897119 0.0145563837684899 0.0736121308444548 GO:0033192 calmodulin-dependent protein phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0140791 histone H2AXS140 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:1990439 MAP kinase serine/threonine phosphatase activity 28/4374 81/18639 0.345679012345679 1.47304780775288 0.0154639767111125 0.0758933174383014 GO:0016831 carboxy-lyase activity 14/4374 34/18639 0.411764705882353 1.75465988864682 0.0164253395304836 0.0803150793218497 GO:0004535 poly(A)-specific ribonuclease activity 7/4374 13/18639 0.538461538461538 2.29455523899968 0.0171882713178864 0.0828275393216991 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 7/4374 13/18639 0.538461538461538 2.29455523899968 0.0171882713178864 0.0828275393216991 GO:0035325 Toll-like receptor binding 7/4374 13/18639 0.538461538461538 2.29455523899968 0.0171882713178864 0.0828275393216991 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 7/4374 13/18639 0.538461538461538 2.29455523899968 0.0171882713178864 0.0828275393216991 GO:0140789 histone phosphatase activity 43/4374 136/18639 0.316176470588235 1.34732812878238 0.0180579307410667 0.0854726907638328 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 30/4374 89/18639 0.337078651685393 1.43639894576224 0.0181050278996279 0.0854726907638328 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 30/4374 89/18639 0.337078651685393 1.43639894576224 0.0181050278996279 0.0854726907638328 GO:0046966 nuclear thyroid hormone receptor binding 12/4374 28/18639 0.428571428571429 1.82627865961199 0.0181227810491736 0.0854726907638328 GO:0051019 mitogen-activated protein kinase binding 12/4374 28/18639 0.428571428571429 1.82627865961199 0.0181227810491736 0.0854726907638328 GO:0051537 2 iron, 2 sulfur cluster binding 12/4374 28/18639 0.428571428571429 1.82627865961199 0.0181227810491736 0.0854726907638328 GO:0005548 phospholipid transporter activity 24/4374 68/18639 0.352941176470588 1.5039941902687 0.0183412498897072 0.0859193618647278 GO:0033549 MAP kinase phosphatase activity 28/4374 82/18639 0.341463414634146 1.45508381009736 0.0183466908041975 0.0859193618647278 GO:0043023 ribosomal large subunit binding 8/4374 16/18639 0.5 2.13065843621399 0.0186557580904189 0.0867448671503775 GO:0140328 floppase activity 8/4374 16/18639 0.5 2.13065843621399 0.0186557580904189 0.0867448671503775 GO:0120020 cholesterol transfer activity 11/4374 25/18639 0.44 1.87497942386831 0.0187804528144824 0.0867448671503775 GO:0001727 lipid kinase activity 16/4374 41/18639 0.390243902439024 1.66295292582555 0.0187838509318111 0.0867448671503775 GO:0008649 rRNA methyltransferase activity 10/4374 22/18639 0.454545454545455 1.93696221473999 0.0191935662057493 0.087422750183721 GO:0033691 sialic acid binding 10/4374 22/18639 0.454545454545455 1.93696221473999 0.0191935662057493 0.087422750183721 GO:0034062 5'-3' RNA polymerase activity 10/4374 22/18639 0.454545454545455 1.93696221473999 0.0191935662057493 0.087422750183721 GO:0097747 RNA polymerase activity 10/4374 22/18639 0.454545454545455 1.93696221473999 0.0191935662057493 0.087422750183721 GO:0045296 cadherin binding 95/4374 334/18639 0.284431137724551 1.21205120622952 0.0193985807073176 0.0880549909240012 GO:0038024 cargo receptor activity 23/4374 65/18639 0.353846153846154 1.50785058562836 0.0200169751194167 0.0902460234197429 GO:0120013 lipid transfer activity 23/4374 65/18639 0.353846153846154 1.50785058562836 0.0200169751194167 0.0902460234197429 GO:0043531 ADP binding 15/4374 38/18639 0.394736842105263 1.6820987654321 0.0201667906638272 0.0906142958881425 GO:0140793 histone H2AXY142 phosphatase activity 30/4374 90/18639 0.333333333333333 1.42043895747599 0.0212083822323543 0.0949735635320918 GO:0016798 hydrolase activity, acting on glycosyl bonds 41/4374 130/18639 0.315384615384615 1.34395378284267 0.0214403418565041 0.095690116339431 GO:0005154 epidermal growth factor receptor binding 14/4374 35/18639 0.4 1.70452674897119 0.0215917673190923 0.0960436472722168 GO:0008080 N-acetyltransferase activity 24/4374 69/18639 0.347826086956522 1.48219717301843 0.0220176003984894 0.0965350348108467 GO:0004715 non-membrane spanning protein tyrosine kinase activity 17/4374 45/18639 0.377777777777778 1.60983081847279 0.0220651508139078 0.0965350348108467 GO:0051539 4 iron, 4 sulfur cluster binding 17/4374 45/18639 0.377777777777778 1.60983081847279 0.0220651508139078 0.0965350348108467 GO:0140303 intramembrane lipid transporter activity 17/4374 45/18639 0.377777777777778 1.60983081847279 0.0220651508139078 0.0965350348108467 GO:0141110 transporter inhibitor activity 17/4374 45/18639 0.377777777777778 1.60983081847279 0.0220651508139078 0.0965350348108467 GO:0022884 macromolecule transmembrane transporter activity 13/4374 32/18639 0.40625 1.73115997942387 0.0230342047853851 0.100115988119484 GO:0120015 sterol transfer activity 13/4374 32/18639 0.40625 1.73115997942387 0.0230342047853851 0.100115988119484 GO:0042626 ATPase-coupled transmembrane transporter activity 32/4374 98/18639 0.326530612244898 1.39145040732342 0.0239638458983078 0.103817312849347 GO:0001222 transcription corepressor binding 18/4374 49/18639 0.36734693877551 1.56538170823885 0.0252983118811059 0.108334379298886 GO:0017018 myosin phosphatase activity 28/4374 84/18639 0.333333333333333 1.42043895747599 0.0253736845674445 0.108334379298886 GO:0019864 IgG binding 6/4374 11/18639 0.545454545454545 2.32435465768799 0.0254137792039492 0.108334379298886 GO:0032050 clathrin heavy chain binding 6/4374 11/18639 0.545454545454545 2.32435465768799 0.0254137792039492 0.108334379298886 GO:0140031 phosphorylation-dependent protein binding 6/4374 11/18639 0.545454545454545 2.32435465768799 0.0254137792039492 0.108334379298886 GO:0004529 DNA exonuclease activity 11/4374 26/18639 0.423076923076923 1.80286483064261 0.0257958355836675 0.108571080146449 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 11/4374 26/18639 0.423076923076923 1.80286483064261 0.0257958355836675 0.108571080146449 GO:0015216 purine nucleotide transmembrane transporter activity 11/4374 26/18639 0.423076923076923 1.80286483064261 0.0257958355836675 0.108571080146449 GO:0052742 phosphatidylinositol kinase activity 11/4374 26/18639 0.423076923076923 1.80286483064261 0.0257958355836675 0.108571080146449 GO:0140102 catalytic activity, acting on a rRNA 10/4374 23/18639 0.434782608695652 1.85274646627304 0.0269627394310142 0.113124427265769 GO:0030983 mismatched DNA binding 7/4374 14/18639 0.5 2.13065843621399 0.0275170727720125 0.114367833708677 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 7/4374 14/18639 0.5 2.13065843621399 0.0275170727720125 0.114367833708677 GO:0046030 inositol trisphosphate phosphatase activity 7/4374 14/18639 0.5 2.13065843621399 0.0275170727720125 0.114367833708677 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 9/4374 20/18639 0.45 1.91759259259259 0.027812415112285 0.114465464454453 GO:0016004 phospholipase activator activity 9/4374 20/18639 0.45 1.91759259259259 0.027812415112285 0.114465464454453 GO:0052745 inositol phosphate phosphatase activity 9/4374 20/18639 0.45 1.91759259259259 0.027812415112285 0.114465464454453 GO:0044390 ubiquitin-like protein conjugating enzyme binding 14/4374 36/18639 0.388888888888889 1.65717878372199 0.0278848199122127 0.114465464454453 GO:0036041 long-chain fatty acid binding 8/4374 17/18639 0.470588235294118 2.00532558702493 0.0281183417997639 0.115068906442111 GO:0071889 14-3-3 protein binding 13/4374 33/18639 0.393939393939394 1.67870058610799 0.0300389816332691 0.122551673534503 GO:0016407 acetyltransferase activity 31/4374 96/18639 0.322916666666667 1.37605024005487 0.0302291516017394 0.122950371958145 GO:0004536 DNA nuclease activity 22/4374 64/18639 0.34375 1.46482767489712 0.0314602431269024 0.1274107478963 GO:0015932 nucleobase-containing compound transmembrane transporter activity 20/4374 57/18639 0.350877192982456 1.49519890260631 0.0315173955322426 0.1274107478963 GO:0031624 ubiquitin conjugating enzyme binding 12/4374 30/18639 0.4 1.70452674897119 0.0322668000840344 0.130044982156866 GO:0032451 demethylase activity 15/4374 40/18639 0.375 1.59799382716049 0.0325941588936587 0.130572985929416 GO:0071949 FAD binding 15/4374 40/18639 0.375 1.59799382716049 0.0325941588936587 0.130572985929416 GO:1990518 single-stranded 3'-5' DNA helicase activity 17/4374 47/18639 0.361702127659574 1.54132737938885 0.0339650621068282 0.135656254060305 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 28/4374 86/18639 0.325581395348837 1.38740549334865 0.0343205555779541 0.136655933290209 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 19/4374 54/18639 0.351851851851852 1.49935223289133 0.034508424941686 0.136655933290209 GO:0008266 poly(U) RNA binding 11/4374 27/18639 0.407407407407407 1.73609205913733 0.0345236041996317 0.136655933290209 GO:0015295 solute:proton symporter activity 10/4374 24/18639 0.416666666666667 1.77554869684499 0.0367343027043464 0.143274553069738 GO:0042625 ATPase-coupled ion transmembrane transporter activity 10/4374 24/18639 0.416666666666667 1.77554869684499 0.0367343027043464 0.143274553069738 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 10/4374 24/18639 0.416666666666667 1.77554869684499 0.0367343027043464 0.143274553069738 GO:0046961 proton-transporting ATPase activity, rotational mechanism 10/4374 24/18639 0.416666666666667 1.77554869684499 0.0367343027043464 0.143274553069738 GO:0060229 lipase activator activity 10/4374 24/18639 0.416666666666667 1.77554869684499 0.0367343027043464 0.143274553069738 GO:0016248 channel inhibitor activity 16/4374 44/18639 0.363636363636364 1.54956977179199 0.0371156704357475 0.14433871836124 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 13/4374 34/18639 0.382352941176471 1.62932703945776 0.0384664743635648 0.149155716919945 GO:0005123 death receptor binding 9/4374 21/18639 0.428571428571429 1.82627865961199 0.0387739376849936 0.14947633948128 GO:0010314 phosphatidylinositol-5-phosphate binding 9/4374 21/18639 0.428571428571429 1.82627865961199 0.0387739376849936 0.14947633948128 GO:0008525 phosphatidylcholine transporter activity 8/4374 18/18639 0.444444444444444 1.89391860996799 0.0404332171468114 0.151359811825839 GO:0016854 racemase and epimerase activity 8/4374 18/18639 0.444444444444444 1.89391860996799 0.0404332171468114 0.151359811825839 GO:0030228 lipoprotein particle receptor activity 8/4374 18/18639 0.444444444444444 1.89391860996799 0.0404332171468114 0.151359811825839 GO:0070628 proteasome binding 8/4374 18/18639 0.444444444444444 1.89391860996799 0.0404332171468114 0.151359811825839 GO:0016829 lyase activity 58/4374 200/18639 0.29 1.23578189300412 0.0404813715749049 0.151359811825839 GO:0005049 nuclear export signal receptor activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0005095 GTPase inhibitor activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0035197 siRNA binding 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:1990459 transferrin receptor binding 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:1990817 poly(A) RNA polymerase activity 6/4374 12/18639 0.5 2.13065843621399 0.0409042791932012 0.151359811825839 GO:0000774 adenyl-nucleotide exchange factor activity 7/4374 15/18639 0.466666666666667 1.98861454046639 0.0413543393214154 0.151359811825839 GO:0005041 low-density lipoprotein particle receptor activity 7/4374 15/18639 0.466666666666667 1.98861454046639 0.0413543393214154 0.151359811825839 GO:0061578 K63-linked deubiquitinase activity 7/4374 15/18639 0.466666666666667 1.98861454046639 0.0413543393214154 0.151359811825839 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 17/4374 48/18639 0.354166666666667 1.50921639231824 0.0414247906049664 0.151359811825839 GO:0043138 3'-5' DNA helicase activity 17/4374 48/18639 0.354166666666667 1.50921639231824 0.0414247906049664 0.151359811825839 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 29/4374 91/18639 0.318681318681319 1.3580020802243 0.0415390454215496 0.151361453179893 GO:0005164 tumor necrosis factor receptor binding 12/4374 31/18639 0.387096774193548 1.64954201513341 0.0417093943212312 0.151566924719228 GO:0004521 RNA endonuclease activity 24/4374 73/18639 0.328767123287671 1.40098088956536 0.0426480899278405 0.154555748239858 GO:0042162 telomeric DNA binding 14/4374 38/18639 0.368421052631579 1.56995884773663 0.0443276234113893 0.159730627134341 GO:0005319 lipid transporter activity 52/4374 178/18639 0.292134831460674 1.24487908632728 0.0443694212882491 0.159730627134341 GO:0015631 tubulin binding 105/4374 385/18639 0.272727272727273 1.162177328844 0.0444363398794782 0.159730627134341 GO:0001618 virus receptor activity 26/4374 81/18639 0.320987654320988 1.36783010719911 0.0475167255712051 0.170342978462811 GO:1901682 sulfur compound transmembrane transporter activity 21/4374 63/18639 0.333333333333333 1.42043895747599 0.0482456909188672 0.17142665275309 GO:0140375 immune receptor activity 46/4374 156/18639 0.294871794871795 1.2565421546903 0.0484152414167629 0.17142665275309 GO:0010485 histone H4 acetyltransferase activity 13/4374 35/18639 0.371428571428571 1.58277483833039 0.0484378921625712 0.17142665275309 GO:0034061 DNA polymerase activity 13/4374 35/18639 0.371428571428571 1.58277483833039 0.0484378921625712 0.17142665275309 GO:0008139 nuclear localization sequence binding 10/4374 25/18639 0.4 1.70452674897119 0.0487035359642556 0.17142665275309 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 10/4374 25/18639 0.4 1.70452674897119 0.0487035359642556 0.17142665275309 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 37/4374 122/18639 0.30327868852459 1.29236659245767 0.0487212592035098 0.17142665275309 GO:0003678 DNA helicase activity 24/4374 74/18639 0.324324324324324 1.38204871538205 0.0495089986804648 0.173738702493452 GO:1902936 phosphatidylinositol bisphosphate binding 34/4374 111/18639 0.306306306306306 1.30526823119416 0.0500981990579257 0.17534369670274 GO:0070034 telomerase RNA binding 9/4374 22/18639 0.409090909090909 1.74326599326599 0.0523295794783167 0.182672810252392 GO:0043425 bHLH transcription factor binding 12/4374 32/18639 0.375 1.59799382716049 0.0529145080427388 0.184231140567651 GO:0051213 dioxygenase activity 29/4374 93/18639 0.311827956989247 1.32879773441303 0.0539970234391096 0.187509245885159 GO:1901505 carbohydrate derivative transmembrane transporter activity 18/4374 53/18639 0.339622641509434 1.44723969252271 0.0542826096847927 0.188010080418683 GO:0140272 exogenous protein binding 26/4374 82/18639 0.317073170731707 1.35114925223326 0.0545365703416256 0.188399061180161 GO:0005346 purine ribonucleotide transmembrane transporter activity 8/4374 19/18639 0.421052631578947 1.79423868312757 0.0558599536529989 0.191973484130461 GO:1990380 K48-linked deubiquitinase activity 8/4374 19/18639 0.421052631578947 1.79423868312757 0.0558599536529989 0.191973484130461 GO:0050660 flavin adenine dinucleotide binding 27/4374 86/18639 0.313953488372093 1.33785529715762 0.0568588931587525 0.194902906961703 GO:0106222 lncRNA binding 11/4374 29/18639 0.379310344827586 1.61636157230027 0.057773924287869 0.197530383811994 GO:0030275 LRR domain binding 7/4374 16/18639 0.4375 1.86432613168724 0.0590087913899682 0.200208399358821 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 7/4374 16/18639 0.4375 1.86432613168724 0.0590087913899682 0.200208399358821 GO:0140327 flippase activity 7/4374 16/18639 0.4375 1.86432613168724 0.0590087913899682 0.200208399358821 GO:0032934 sterol binding 22/4374 68/18639 0.323529411764706 1.37866134107964 0.0596683217243431 0.200279508018766 GO:0046332 SMAD binding 25/4374 79/18639 0.316455696202532 1.34851799760379 0.0597738991029614 0.200279508018766 GO:0008200 ion channel inhibitor activity 15/4374 43/18639 0.348837209302326 1.48650588573069 0.0604625108176624 0.200279508018766 GO:0048156 tau protein binding 15/4374 43/18639 0.348837209302326 1.48650588573069 0.0604625108176624 0.200279508018766 GO:0009982 pseudouridine synthase activity 6/4374 13/18639 0.461538461538462 1.9667616334283 0.0612322859434711 0.200279508018766 GO:0032396 inhibitory MHC class I receptor activity 6/4374 13/18639 0.461538461538462 1.9667616334283 0.0612322859434711 0.200279508018766 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 6/4374 13/18639 0.461538461538462 1.9667616334283 0.0612322859434711 0.200279508018766 GO:0046974 histone H3K9 methyltransferase activity 6/4374 13/18639 0.461538461538462 1.9667616334283 0.0612322859434711 0.200279508018766 GO:0004445 inositol-polyphosphate 5-phosphatase activity 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0008140 cAMP response element binding protein binding 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0043422 protein kinase B binding 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0051864 histone H3K36 demethylase activity 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0051880 G-quadruplex DNA binding 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0070513 death domain binding 5/4374 10/18639 0.5 2.13065843621399 0.0614391272719222 0.200279508018766 GO:0050681 nuclear androgen receptor binding 10/4374 26/18639 0.384615384615385 1.63896802785692 0.0630208487021232 0.204933322185388 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 74/4374 268/18639 0.276119402985075 1.17663227074504 0.0636541195067748 0.206487753521977 GO:0015485 cholesterol binding 18/4374 54/18639 0.333333333333333 1.42043895747599 0.0641697020563461 0.207653780376984 GO:0061749 forked DNA-dependent helicase activity 16/4374 47/18639 0.340425531914894 1.45066106295421 0.0657895853370682 0.21147396570612 GO:0140359 ABC-type transporter activity 16/4374 47/18639 0.340425531914894 1.45066106295421 0.0657895853370682 0.21147396570612 GO:0019239 deaminase activity 12/4374 33/18639 0.363636363636364 1.54956977179199 0.0659862374195787 0.21147396570612 GO:0140416 transcription regulator inhibitor activity 12/4374 33/18639 0.363636363636364 1.54956977179199 0.0659862374195787 0.21147396570612 GO:0000295 adenine nucleotide transmembrane transporter activity 9/4374 23/18639 0.391304347826087 1.66747181964573 0.0686368337944395 0.219439877275492 GO:0003743 translation initiation factor activity 17/4374 51/18639 0.333333333333333 1.42043895747599 0.0706972642146244 0.225485279149761 GO:0001614 purinergic nucleotide receptor activity 8/4374 20/18639 0.4 1.70452674897119 0.0745583126801416 0.236101323487115 GO:0016502 nucleotide receptor activity 8/4374 20/18639 0.4 1.70452674897119 0.0745583126801416 0.236101323487115 GO:0061608 nuclear import signal receptor activity 8/4374 20/18639 0.4 1.70452674897119 0.0745583126801416 0.236101323487115 GO:0009378 four-way junction helicase activity 16/4374 48/18639 0.333333333333333 1.42043895747599 0.0779719827031191 0.245741082926892 GO:0036121 double-stranded DNA helicase activity 16/4374 48/18639 0.333333333333333 1.42043895747599 0.0779719827031191 0.245741082926892 GO:0036002 pre-mRNA binding 19/4374 59/18639 0.322033898305085 1.37228848434121 0.0793816089397281 0.249592292883779 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 14/4374 41/18639 0.341463414634146 1.45508381009736 0.0800741314054567 0.251149182944117 GO:0004659 prenyltransferase activity 7/4374 17/18639 0.411764705882353 1.75465988864682 0.0806321061031112 0.251149182944117 GO:0015278 intracellularly gated calcium channel activity 7/4374 17/18639 0.411764705882353 1.75465988864682 0.0806321061031112 0.251149182944117 GO:0070403 NAD+ binding 7/4374 17/18639 0.411764705882353 1.75465988864682 0.0806321061031112 0.251149182944117 GO:0030332 cyclin binding 12/4374 34/18639 0.352941176470588 1.5039941902687 0.0809970172683136 0.25169633870761 GO:0035064 methylated histone binding 23/4374 74/18639 0.310810810810811 1.32446335224113 0.0820327751662546 0.254320724874402 GO:0051219 phosphoprotein binding 28/4374 93/18639 0.301075268817204 1.28297712288154 0.0845151800425387 0.261407417340875 GO:0005347 ATP transmembrane transporter activity 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0005545 1-phosphatidylinositol binding 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0008559 ABC-type xenobiotic transporter activity 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0019992 diacylglycerol binding 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0032454 histone H3K9 demethylase activity 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0070742 C2H2 zinc finger domain binding 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:1990825 sequence-specific mRNA binding 6/4374 14/18639 0.428571428571429 1.82627865961199 0.086518695822065 0.263317769893241 GO:0140033 acetylation-dependent protein binding 9/4374 24/18639 0.375 1.59799382716049 0.0877783524484956 0.26593441630182 GO:0140612 DNA damage sensor activity 9/4374 24/18639 0.375 1.59799382716049 0.0877783524484956 0.26593441630182 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0005225 volume-sensitive anion channel activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0005536 D-glucose binding 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0008526 phosphatidylinositol transfer activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0015173 aromatic amino acid transmembrane transporter activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0016176 superoxide-generating NADPH oxidase activator activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0019107 myristoyltransferase activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0047676 arachidonate-CoA ligase activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0140537 transcription regulator activator activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0180030 inositol phosphate kinase activity 5/4374 11/18639 0.454545454545455 1.93696221473999 0.0914602506618997 0.269532406214622 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 19/4374 60/18639 0.316666666666667 1.34941700960219 0.091600486924067 0.269532406214622 GO:0001217 DNA-binding transcription repressor activity 75/4374 278/18639 0.26978417266187 1.14963584687805 0.0946834349339525 0.277988892852443 GO:0004402 histone acetyltransferase activity 14/4374 42/18639 0.333333333333333 1.42043895747599 0.095198843525852 0.278273542614029 GO:0004520 DNA endonuclease activity 14/4374 42/18639 0.333333333333333 1.42043895747599 0.095198843525852 0.278273542614029 GO:0034212 protein N-acetyltransferase activity 17/4374 53/18639 0.320754716981132 1.36683748738256 0.0964587627299367 0.279240631469569 GO:0035613 RNA stem-loop binding 8/4374 21/18639 0.380952380952381 1.62335880854399 0.0965794665233097 0.279240631469569 GO:0051010 microtubule plus-end binding 8/4374 21/18639 0.380952380952381 1.62335880854399 0.0965794665233097 0.279240631469569 GO:0072542 protein phosphatase activator activity 8/4374 21/18639 0.380952380952381 1.62335880854399 0.0965794665233097 0.279240631469569 GO:1904047 S-adenosyl-L-methionine binding 8/4374 21/18639 0.380952380952381 1.62335880854399 0.0965794665233097 0.279240631469569 GO:0097718 disordered domain specific binding 10/4374 28/18639 0.357142857142857 1.52189888300999 0.0990328404654267 0.285712967069452 GO:0070279 vitamin B6 binding 18/4374 57/18639 0.315789473684211 1.34567901234568 0.100917418643581 0.290519841549704 GO:0030276 clathrin binding 15/4374 46/18639 0.326086956521739 1.38955984970478 0.101166839628984 0.290608848178292 GO:0140034 methylation-dependent protein binding 23/4374 76/18639 0.302631578947368 1.28960905349794 0.104979730607815 0.300911727819814 GO:0032393 MHC class I receptor activity 7/4374 18/18639 0.388888888888889 1.65717878372199 0.10621321725712 0.303792642907462 GO:0017025 TBP-class protein binding 9/4374 25/18639 0.36 1.53407407407407 0.109757936720881 0.313257630555303 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 17/4374 54/18639 0.314814814814815 1.34152568206066 0.111294277093478 0.316962288082068 GO:0017116 single-stranded DNA helicase activity 18/4374 58/18639 0.310344827586207 1.32247765006386 0.115599321002224 0.328519437890937 GO:0004953 icosanoid receptor activity 6/4374 15/18639 0.4 1.70452674897119 0.116628266822498 0.330033180582813 GO:0120283 protein serine/threonine kinase binding 6/4374 15/18639 0.4 1.70452674897119 0.116628266822498 0.330033180582813 GO:0061733 protein-lysine-acetyltransferase activity 15/4374 47/18639 0.319148936170213 1.35999474651957 0.11774992757832 0.332499795497167 GO:0035250 UDP-galactosyltransferase activity 10/4374 29/18639 0.344827586206897 1.46941961118206 0.120748059506246 0.340243472761245 GO:0061133 endopeptidase activator activity 8/4374 22/18639 0.363636363636364 1.54956977179199 0.121865116263306 0.342665126068069 GO:0015036 disulfide oxidoreductase activity 13/4374 40/18639 0.325 1.38492798353909 0.124123678602749 0.347546300087696 GO:0015144 carbohydrate transmembrane transporter activity 13/4374 40/18639 0.325 1.38492798353909 0.124123678602749 0.347546300087696 GO:0005126 cytokine receptor binding 73/4374 275/18639 0.265454545454545 1.13118593340816 0.127416996506208 0.352744919491872 GO:0004126 cytidine deaminase activity 5/4374 12/18639 0.416666666666667 1.77554869684499 0.127571658853827 0.352744919491872 GO:0034452 dynactin binding 5/4374 12/18639 0.416666666666667 1.77554869684499 0.127571658853827 0.352744919491872 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/4374 12/18639 0.416666666666667 1.77554869684499 0.127571658853827 0.352744919491872 GO:0035259 nuclear glucocorticoid receptor binding 5/4374 12/18639 0.416666666666667 1.77554869684499 0.127571658853827 0.352744919491872 GO:0035497 cAMP response element binding 5/4374 12/18639 0.416666666666667 1.77554869684499 0.127571658853827 0.352744919491872 GO:0001046 core promoter sequence-specific DNA binding 14/4374 44/18639 0.318181818181818 1.35587355031799 0.130368608523056 0.358986023469284 GO:0001223 transcription coactivator binding 14/4374 44/18639 0.318181818181818 1.35587355031799 0.130368608523056 0.358986023469284 GO:0008143 poly(A) binding 9/4374 26/18639 0.346153846153846 1.47507122507123 0.134501100966105 0.367323335287309 GO:0070006 metalloaminopeptidase activity 9/4374 26/18639 0.346153846153846 1.47507122507123 0.134501100966105 0.367323335287309 GO:0097602 cullin family protein binding 9/4374 26/18639 0.346153846153846 1.47507122507123 0.134501100966105 0.367323335287309 GO:0120014 phospholipid transfer activity 9/4374 26/18639 0.346153846153846 1.47507122507123 0.134501100966105 0.367323335287309 GO:0003756 protein disulfide isomerase activity 7/4374 19/18639 0.368421052631579 1.56995884773663 0.135585954359524 0.368019018975852 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 7/4374 19/18639 0.368421052631579 1.56995884773663 0.135585954359524 0.368019018975852 GO:0120227 acyl-CoA binding 7/4374 19/18639 0.368421052631579 1.56995884773663 0.135585954359524 0.368019018975852 GO:0140318 protein transporter activity 13/4374 41/18639 0.317073170731707 1.35114925223326 0.144575254087206 0.388431498680483 GO:0035925 mRNA 3'-UTR AU-rich region binding 10/4374 30/18639 0.333333333333333 1.42043895747599 0.144851485898536 0.388431498680483 GO:0043995 histone H4K5 acetyltransferase activity 10/4374 30/18639 0.333333333333333 1.42043895747599 0.144851485898536 0.388431498680483 GO:0043996 histone H4K8 acetyltransferase activity 10/4374 30/18639 0.333333333333333 1.42043895747599 0.144851485898536 0.388431498680483 GO:0043997 histone H4K12 acetyltransferase activity 10/4374 30/18639 0.333333333333333 1.42043895747599 0.144851485898536 0.388431498680483 GO:0030170 pyridoxal phosphate binding 17/4374 56/18639 0.303571428571429 1.29361405055849 0.144858664169564 0.388431498680483 GO:0044013 histone H2B acetyltransferase activity 8/4374 23/18639 0.347826086956522 1.48219717301843 0.150253533580034 0.397422798950752 GO:0070577 lysine-acetylated histone binding 8/4374 23/18639 0.347826086956522 1.48219717301843 0.150253533580034 0.397422798950752 GO:0000062 fatty-acyl-CoA binding 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0004707 MAP kinase activity 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0005149 interleukin-1 receptor binding 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0008296 3'-5'-DNA exonuclease activity 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0022858 alanine transmembrane transporter activity 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0034450 ubiquitin-ubiquitin ligase activity 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0070411 I-SMAD binding 6/4374 16/18639 0.375 1.59799382716049 0.151199952082016 0.397422798950752 GO:0015035 protein-disulfide reductase activity 11/4374 34/18639 0.323529411764706 1.37866134107964 0.153435708945441 0.402503930764173 GO:0140296 general transcription initiation factor binding 16/4374 53/18639 0.30188679245283 1.28643528224241 0.159729269834292 0.418188836377181 GO:0005044 scavenger receptor activity 9/4374 27/18639 0.333333333333333 1.42043895747599 0.161859684597363 0.422104667675476 GO:0008320 protein transmembrane transporter activity 9/4374 27/18639 0.333333333333333 1.42043895747599 0.161859684597363 0.422104667675476 GO:0140664 ATP-dependent DNA damage sensor activity 7/4374 20/18639 0.35 1.49146090534979 0.168446992186884 0.435687810091713 GO:0140939 histone H4 methyltransferase activity 7/4374 20/18639 0.35 1.49146090534979 0.168446992186884 0.435687810091713 GO:0017154 semaphorin receptor activity 5/4374 13/18639 0.384615384615385 1.63896802785692 0.1690337669228 0.435687810091713 GO:0019855 calcium channel inhibitor activity 5/4374 13/18639 0.384615384615385 1.63896802785692 0.1690337669228 0.435687810091713 GO:0097157 pre-mRNA intronic binding 5/4374 13/18639 0.384615384615385 1.63896802785692 0.1690337669228 0.435687810091713 GO:0140333 glycerophospholipid flippase activity 5/4374 13/18639 0.384615384615385 1.63896802785692 0.1690337669228 0.435687810091713 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 8/4374 24/18639 0.333333333333333 1.42043895747599 0.181491124145804 0.465092861491173 GO:0043998 histone H2A acetyltransferase activity 8/4374 24/18639 0.333333333333333 1.42043895747599 0.181491124145804 0.465092861491173 GO:0070300 phosphatidic acid binding 8/4374 24/18639 0.333333333333333 1.42043895747599 0.181491124145804 0.465092861491173 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/4374 39/18639 0.307692307692308 1.31117442228553 0.185165676930304 0.470689740480248 GO:0015179 L-amino acid transmembrane transporter activity 18/4374 62/18639 0.290322580645161 1.23715651135006 0.186250922480635 0.470689740480248 GO:0004955 prostaglandin receptor activity 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0005345 purine nucleobase transmembrane transporter activity 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0005522 profilin binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0005528 FK506 binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0008190 eukaryotic initiation factor 4E binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0030957 Tat protein binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0032356 oxidized DNA binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0033204 ribonuclease P RNA binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0050308 sugar-phosphatase activity 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0071723 lipopeptide binding 4/4374 10/18639 0.4 1.70452674897119 0.189417046638488 0.470689740480248 GO:0004549 tRNA-specific ribonuclease activity 6/4374 17/18639 0.352941176470588 1.5039941902687 0.189691504434145 0.470689740480248 GO:0046965 nuclear retinoid X receptor binding 6/4374 17/18639 0.352941176470588 1.5039941902687 0.189691504434145 0.470689740480248 GO:1901567 fatty acid derivative binding 6/4374 17/18639 0.352941176470588 1.5039941902687 0.189691504434145 0.470689740480248 GO:0008375 acetylglucosaminyltransferase activity 13/4374 43/18639 0.302325581395349 1.2883051009666 0.190430780216559 0.471080022768231 GO:0016866 intramolecular transferase activity 9/4374 28/18639 0.321428571428571 1.36970899470899 0.191619768659859 0.471080022768231 GO:0046625 sphingolipid binding 9/4374 28/18639 0.321428571428571 1.36970899470899 0.191619768659859 0.471080022768231 GO:0051119 sugar transmembrane transporter activity 9/4374 28/18639 0.321428571428571 1.36970899470899 0.191619768659859 0.471080022768231 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 9/4374 28/18639 0.321428571428571 1.36970899470899 0.191619768659859 0.471080022768231 GO:0001784 phosphotyrosine residue binding 14/4374 47/18639 0.297872340425532 1.26932843008493 0.194850798212155 0.478139412587022 GO:0005048 signal sequence binding 15/4374 51/18639 0.294117647058824 1.25332849189058 0.198580447163842 0.485415736788909 GO:0016410 N-acyltransferase activity 26/4374 94/18639 0.276595744680851 1.17866211365029 0.198758342800052 0.485415736788909 GO:0008378 galactosyltransferase activity 10/4374 32/18639 0.3125 1.33166152263374 0.199640908288371 0.485415736788909 GO:0031369 translation initiation factor binding 10/4374 32/18639 0.3125 1.33166152263374 0.199640908288371 0.485415736788909 GO:0042910 xenobiotic transmembrane transporter activity 10/4374 32/18639 0.3125 1.33166152263374 0.199640908288371 0.485415736788909 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 35/4374 130/18639 0.269230769230769 1.14727761949984 0.201856843875747 0.489908033494058 GO:0001846 opsonin binding 7/4374 21/18639 0.333333333333333 1.42043895747599 0.204380755018672 0.493427016574227 GO:0070182 DNA polymerase binding 7/4374 21/18639 0.333333333333333 1.42043895747599 0.204380755018672 0.493427016574227 GO:0045309 protein phosphorylated amino acid binding 17/4374 59/18639 0.288135593220339 1.22783706493688 0.204419764009323 0.493427016574227 GO:0004705 JUN kinase activity 5/4374 14/18639 0.357142857142857 1.52189888300999 0.214875473089875 0.513009176346552 GO:0015386 potassium:proton antiporter activity 5/4374 14/18639 0.357142857142857 1.52189888300999 0.214875473089875 0.513009176346552 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 5/4374 14/18639 0.357142857142857 1.52189888300999 0.214875473089875 0.513009176346552 GO:0098847 sequence-specific single stranded DNA binding 5/4374 14/18639 0.357142857142857 1.52189888300999 0.214875473089875 0.513009176346552 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 8/4374 25/18639 0.32 1.36362139917695 0.21524791822812 0.513009176346552 GO:0019211 phosphatase activator activity 8/4374 25/18639 0.32 1.36362139917695 0.21524791822812 0.513009176346552 GO:0047617 fatty acyl-CoA hydrolase activity 8/4374 25/18639 0.32 1.36362139917695 0.21524791822812 0.513009176346552 GO:0016790 thiolester hydrolase activity 13/4374 44/18639 0.295454545454545 1.259025439581 0.215618142539641 0.513009176346552 GO:0030159 signaling receptor complex adaptor activity 15/4374 52/18639 0.288461538461538 1.22922602089269 0.222074382748767 0.527426659028322 GO:0010484 histone H3 acetyltransferase activity 9/4374 29/18639 0.310344827586207 1.32247765006386 0.223512037778985 0.52895197552678 GO:0051861 glycolipid binding 9/4374 29/18639 0.310344827586207 1.32247765006386 0.223512037778985 0.52895197552678 GO:0140223 general transcription initiation factor activity 19/4374 68/18639 0.279411764705882 1.19066206729605 0.229479399715508 0.541619752457979 GO:0000400 four-way junction DNA binding 6/4374 18/18639 0.333333333333333 1.42043895747599 0.231430648022658 0.541619752457979 GO:0008308 voltage-gated monoatomic anion channel activity 6/4374 18/18639 0.333333333333333 1.42043895747599 0.231430648022658 0.541619752457979 GO:0015172 acidic amino acid transmembrane transporter activity 6/4374 18/18639 0.333333333333333 1.42043895747599 0.231430648022658 0.541619752457979 GO:0035615 clathrin adaptor activity 6/4374 18/18639 0.333333333333333 1.42043895747599 0.231430648022658 0.541619752457979 GO:1990381 ubiquitin-specific protease binding 6/4374 18/18639 0.333333333333333 1.42043895747599 0.231430648022658 0.541619752457979 GO:0031490 chromatin DNA binding 34/4374 128/18639 0.265625 1.13191229423868 0.231715518156834 0.541619752457979 GO:0043178 alcohol binding 25/4374 92/18639 0.271739130434783 1.15796654142065 0.233265671706663 0.542145908590358 GO:0001530 lipopolysaccharide binding 12/4374 41/18639 0.292682926829268 1.24721469436917 0.23894775236434 0.542145908590358 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/4374 41/18639 0.292682926829268 1.24721469436917 0.23894775236434 0.542145908590358 GO:0016877 ligase activity, forming carbon-sulfur bonds 12/4374 41/18639 0.292682926829268 1.24721469436917 0.23894775236434 0.542145908590358 GO:0022804 active transmembrane transporter activity 114/4374 457/18639 0.24945295404814 1.06299808196234 0.24073417775825 0.542145908590358 GO:0008009 chemokine activity 13/4374 45/18639 0.288888888888889 1.2310470964792 0.24212853557792 0.542145908590358 GO:0032931 histone H3K56 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0043992 histone H3K9 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0043993 histone H3K18 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0043994 histone H3K23 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0043999 histone H2AK5 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044012 histone H2AK9 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044014 histone H2BK5 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044015 histone H2BK12 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044016 histone H3K4 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044017 histone H3K27 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0044018 histone H3K36 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0046972 histone H4K16 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0050321 tau-protein kinase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0140908 histone H3K122 acetyltransferase activity 7/4374 22/18639 0.318181818181818 1.35587355031799 0.242888053104509 0.542145908590358 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0000099 sulfur amino acid transmembrane transporter activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0004143 ATP-dependent diacylglycerol kinase activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0004954 prostanoid receptor activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0015205 nucleobase transmembrane transporter activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0015217 ADP transmembrane transporter activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0019203 carbohydrate phosphatase activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0032794 GTPase activating protein binding 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0034713 type I transforming growth factor beta receptor binding 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0043522 leucine zipper domain binding 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0050786 RAGE receptor binding 4/4374 11/18639 0.363636363636364 1.54956977179199 0.24539235862511 0.542145908590358 GO:0019843 rRNA binding 18/4374 65/18639 0.276923076923077 1.18005698005698 0.250477297355825 0.545768091689273 GO:0005227 calcium-activated cation channel activity 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0008157 protein phosphatase 1 binding 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0008198 ferrous iron binding 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0015145 monosaccharide transmembrane transporter activity 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0016289 acyl-CoA hydrolase activity 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0034237 protein kinase A regulatory subunit binding 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0050750 low-density lipoprotein particle receptor binding 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0051139 metal cation:proton antiporter activity 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0070412 R-SMAD binding 8/4374 26/18639 0.307692307692308 1.31117442228553 0.251135392566793 0.545768091689273 GO:0015101 organic cation transmembrane transporter activity 22/4374 81/18639 0.271604938271605 1.15739470609155 0.252169057228114 0.54712046674289 GO:0015399 primary active transmembrane transporter activity 43/4374 166/18639 0.259036144578313 1.10383509346026 0.254241824253408 0.550719261004939 GO:0051721 protein phosphatase 2A binding 9/4374 30/18639 0.3 1.2783950617284 0.257223702870606 0.556272398077896 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 10/4374 34/18639 0.294117647058824 1.25332849189058 0.261788045444086 0.564499632439454 GO:0004467 long-chain fatty acid-CoA ligase activity 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0015929 hexosaminidase activity 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0034483 heparan sulfate sulfotransferase activity 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0042809 nuclear vitamin D receptor binding 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0055105 ubiquitin-protein transferase inhibitor activity 5/4374 15/18639 0.333333333333333 1.42043895747599 0.263999076223564 0.564499632439454 GO:0019894 kinesin binding 12/4374 42/18639 0.285714285714286 1.217519106408 0.267843050471088 0.570883424882288 GO:0048487 beta-tubulin binding 12/4374 42/18639 0.285714285714286 1.217519106408 0.267843050471088 0.570883424882288 GO:0050661 NADP binding 15/4374 54/18639 0.277777777777778 1.18369913123 0.272284812954016 0.578496487586009 GO:0051287 NAD binding 15/4374 54/18639 0.277777777777778 1.18369913123 0.272284812954016 0.578496487586009 GO:0048029 monosaccharide binding 20/4374 74/18639 0.27027027027027 1.15170726281837 0.273529242970053 0.579204831661629 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 58/4374 229/18639 0.253275109170306 1.07928549607346 0.274668567212673 0.579204831661629 GO:0015245 fatty acid transmembrane transporter activity 6/4374 19/18639 0.315789473684211 1.34567901234568 0.275666660482565 0.579204831661629 GO:0022821 solute:potassium antiporter activity 6/4374 19/18639 0.315789473684211 1.34567901234568 0.275666660482565 0.579204831661629 GO:0042800 histone H3K4 methyltransferase activity 6/4374 19/18639 0.315789473684211 1.34567901234568 0.275666660482565 0.579204831661629 GO:0046624 sphingolipid transporter activity 6/4374 19/18639 0.315789473684211 1.34567901234568 0.275666660482565 0.579204831661629 GO:0097001 ceramide binding 6/4374 19/18639 0.315789473684211 1.34567901234568 0.275666660482565 0.579204831661629 GO:0070851 growth factor receptor binding 36/4374 139/18639 0.258992805755396 1.10365041300293 0.277520677728847 0.582180601544743 GO:0042826 histone deacetylase binding 33/4374 127/18639 0.259842519685039 1.10727131330806 0.28133348192589 0.589249655057376 GO:0042171 lysophosphatidic acid acyltransferase activity 7/4374 23/18639 0.304347826086957 1.29692252639113 0.283415655396467 0.590819469713638 GO:0043274 phospholipase binding 7/4374 23/18639 0.304347826086957 1.29692252639113 0.283415655396467 0.590819469713638 GO:0071617 lysophospholipid acyltransferase activity 7/4374 23/18639 0.304347826086957 1.29692252639113 0.283415655396467 0.590819469713638 GO:0005385 zinc ion transmembrane transporter activity 8/4374 27/18639 0.296296296296296 1.26261240664533 0.288725164343396 0.600006982151119 GO:0023026 MHC class II protein complex binding 8/4374 27/18639 0.296296296296296 1.26261240664533 0.288725164343396 0.600006982151119 GO:0016878 acid-thiol ligase activity 9/4374 31/18639 0.290322580645161 1.23715651135006 0.292411145718279 0.605773868855625 GO:0070325 lipoprotein particle receptor binding 9/4374 31/18639 0.290322580645161 1.23715651135006 0.292411145718279 0.605773868855625 GO:0001540 amyloid-beta binding 22/4374 83/18639 0.265060240963855 1.1295056770291 0.294195274566576 0.608522107579387 GO:0002020 protease binding 35/4374 136/18639 0.257352941176471 1.09666243040426 0.295435188785088 0.610137889882247 GO:0000217 DNA secondary structure binding 11/4374 39/18639 0.282051282051282 1.20190988709507 0.296692591788283 0.610441330798339 GO:0140299 molecular sensor activity 19/4374 71/18639 0.267605633802817 1.14035240248073 0.296825808942288 0.610441330798339 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 12/4374 43/18639 0.27906976744186 1.18920470858455 0.297809090569616 0.610441330798339 GO:0005504 fatty acid binding 13/4374 47/18639 0.276595744680851 1.17866211365029 0.298457595574134 0.610441330798339 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0004300 enoyl-CoA hydratase activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0004526 ribonuclease P activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0004859 phospholipase inhibitor activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0005527 macrolide binding 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0008603 cAMP-dependent protein kinase regulator activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0015269 calcium-activated potassium channel activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0015368 calcium:monoatomic cation antiporter activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0016208 AMP binding 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0016273 arginine N-methyltransferase activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0016274 protein-arginine N-methyltransferase activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0017166 vinculin binding 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0043047 single-stranded telomeric DNA binding 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/4374 12/18639 0.333333333333333 1.42043895747599 0.304302708510751 0.610441330798339 GO:0005496 steroid binding 28/4374 108/18639 0.259259259259259 1.10478585581466 0.306515544722576 0.613954329037689 GO:0052689 carboxylic ester hydrolase activity 24/4374 92/18639 0.260869565217391 1.11164787976382 0.312894799186564 0.625789598373129 GO:0003688 DNA replication origin binding 5/4374 16/18639 0.3125 1.33166152263374 0.315271405378813 0.625837267393763 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/4374 16/18639 0.3125 1.33166152263374 0.315271405378813 0.625837267393763 GO:0005521 lamin binding 5/4374 16/18639 0.3125 1.33166152263374 0.315271405378813 0.625837267393763 GO:0015385 sodium:proton antiporter activity 5/4374 16/18639 0.3125 1.33166152263374 0.315271405378813 0.625837267393763 GO:0055102 lipase inhibitor activity 5/4374 16/18639 0.3125 1.33166152263374 0.315271405378813 0.625837267393763 GO:0015149 hexose transmembrane transporter activity 7/4374 24/18639 0.291666666666667 1.2428840877915 0.325384580029093 0.6437205801116 GO:0055056 D-glucose transmembrane transporter activity 7/4374 24/18639 0.291666666666667 1.2428840877915 0.325384580029093 0.6437205801116 GO:0015291 secondary active transmembrane transporter activity 71/4374 287/18639 0.247386759581882 1.05419337262156 0.325732293545193 0.6437205801116 GO:0036408 histone H3K14 acetyltransferase activity 8/4374 28/18639 0.285714285714286 1.217519106408 0.32756732261681 0.645526329983344 GO:0016879 ligase activity, forming carbon-nitrogen bonds 13/4374 48/18639 0.270833333333333 1.15410665294925 0.327913534122755 0.645526329983344 GO:0071813 lipoprotein particle binding 9/4374 32/18639 0.28125 1.19849537037037 0.32871254297346 0.645526329983344 GO:0071814 protein-lipid complex binding 9/4374 32/18639 0.28125 1.19849537037037 0.32871254297346 0.645526329983344 GO:0004177 aminopeptidase activity 11/4374 40/18639 0.275 1.1718621399177 0.329072820848652 0.645526329983344 GO:0016757 glycosyltransferase activity 66/4374 267/18639 0.247191011235955 1.05335922689231 0.335850265504476 0.657851035524232 GO:0051015 actin filament binding 52/4374 209/18639 0.248803827751196 1.06023194912084 0.339225494103222 0.663485157584243 GO:0015297 antiporter activity 34/4374 135/18639 0.251851851851852 1.07322054564853 0.349740492376838 0.683046776594999 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 16/4374 61/18639 0.262295081967213 1.11772245834177 0.351423317919788 0.683573299091431 GO:0019905 syntaxin binding 16/4374 61/18639 0.262295081967213 1.11772245834177 0.351423317919788 0.683573299091431 GO:0016251 RNA polymerase II general transcription initiation factor activity 14/4374 53/18639 0.264150943396226 1.12563087196211 0.355815307877819 0.683573299091431 GO:0016860 intramolecular oxidoreductase activity 14/4374 53/18639 0.264150943396226 1.12563087196211 0.355815307877819 0.683573299091431 GO:0051018 protein kinase A binding 14/4374 53/18639 0.264150943396226 1.12563087196211 0.355815307877819 0.683573299091431 GO:0017080 sodium channel regulator activity 11/4374 41/18639 0.268292682926829 1.14328013650507 0.362118679292901 0.683573299091431 GO:0140828 metal cation:monoatomic cation antiporter activity 11/4374 41/18639 0.268292682926829 1.14328013650507 0.362118679292901 0.683573299091431 GO:0043394 proteoglycan binding 10/4374 37/18639 0.27027027027027 1.15170726281837 0.364031006466863 0.683573299091431 GO:0005035 death receptor activity 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0005542 folic acid binding 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0019104 DNA N-glycosylase activity 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0061459 L-arginine transmembrane transporter activity 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0071714 icosanoid transmembrane transporter activity 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/4374 13/18639 0.307692307692308 1.31117442228553 0.364422238105396 0.683573299091431 GO:0016417 S-acyltransferase activity 8/4374 29/18639 0.275862068965517 1.17553568894565 0.367207431126458 0.683573299091431 GO:0099604 ligand-gated calcium channel activity 8/4374 29/18639 0.275862068965517 1.17553568894565 0.367207431126458 0.683573299091431 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0005092 GDP-dissociation inhibitor activity 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0008484 sulfuric ester hydrolase activity 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0016805 dipeptidase activity 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0030169 low-density lipoprotein particle binding 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0032183 SUMO binding 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0070402 NADPH binding 5/4374 17/18639 0.294117647058824 1.25332849189058 0.367596364105759 0.683573299091431 GO:0000030 mannosyltransferase activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0008483 transaminase activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0015662 P-type ion transporter activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0019706 protein-cysteine S-palmitoyltransferase activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0019707 protein-cysteine S-acyltransferase activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0042974 nuclear retinoic acid receptor binding 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0140358 P-type transmembrane transporter activity 7/4374 25/18639 0.28 1.19316872427984 0.368215504062804 0.683573299091431 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/4374 21/18639 0.285714285714286 1.217519106408 0.368512823645531 0.683573299091431 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/4374 21/18639 0.285714285714286 1.217519106408 0.368512823645531 0.683573299091431 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6/4374 21/18639 0.285714285714286 1.217519106408 0.368512823645531 0.683573299091431 GO:0019200 carbohydrate kinase activity 6/4374 21/18639 0.285714285714286 1.217519106408 0.368512823645531 0.683573299091431 GO:0140312 cargo adaptor activity 6/4374 21/18639 0.285714285714286 1.217519106408 0.368512823645531 0.683573299091431 GO:0008028 monocarboxylic acid transmembrane transporter activity 18/4374 70/18639 0.257142857142857 1.0957671957672 0.372403022591885 0.689827325971041 GO:0003774 cytoskeletal motor activity 38/4374 153/18639 0.248366013071895 1.05836628204094 0.374255317611116 0.692294259280646 GO:0017069 snRNA binding 14/4374 54/18639 0.259259259259259 1.10478585581466 0.38505098110115 0.711274728978513 GO:0016835 carbon-oxygen lyase activity 20/4374 79/18639 0.253164556962025 1.07881439808303 0.390767575400828 0.72083339151609 GO:0016859 cis-trans isomerase activity 11/4374 42/18639 0.261904761904762 1.116059180874 0.39557132177806 0.728684013801689 GO:0016874 ligase activity 41/4374 167/18639 0.245508982035928 1.04619156748232 0.39927358217857 0.734486672610647 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 17/4374 67/18639 0.253731343283582 1.08122965419815 0.401928725946911 0.738349731366563 GO:1990782 protein tyrosine kinase binding 29/4374 117/18639 0.247863247863248 1.05622384017446 0.402690503849893 0.738728786372907 GO:0001965 G-protein alpha-subunit binding 8/4374 30/18639 0.266666666666667 1.1363511659808 0.407201514128587 0.742905368711963 GO:0001968 fibronectin binding 8/4374 30/18639 0.266666666666667 1.1363511659808 0.407201514128587 0.742905368711963 GO:0016769 transferase activity, transferring nitrogenous groups 8/4374 30/18639 0.266666666666667 1.1363511659808 0.407201514128587 0.742905368711963 GO:0022839 monoatomic ion-gated channel activity 8/4374 30/18639 0.266666666666667 1.1363511659808 0.407201514128587 0.742905368711963 GO:0004857 enzyme inhibitor activity 100/4374 416/18639 0.240384615384615 1.02435501741057 0.409414669013202 0.744348129301465 GO:0051117 ATPase binding 21/4374 84/18639 0.25 1.065329218107 0.411052187989391 0.744348129301465 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/4374 26/18639 0.269230769230769 1.14727761949984 0.411350281982388 0.744348129301465 GO:0005160 transforming growth factor beta receptor binding 7/4374 26/18639 0.269230769230769 1.14727761949984 0.411350281982388 0.744348129301465 GO:0019865 immunoglobulin binding 7/4374 26/18639 0.269230769230769 1.14727761949984 0.411350281982388 0.744348129301465 GO:0030507 spectrin binding 7/4374 26/18639 0.269230769230769 1.14727761949984 0.411350281982388 0.744348129301465 GO:0015078 proton transmembrane transporter activity 45/4374 185/18639 0.243243243243243 1.03653653653654 0.419223008779091 0.746022344083011 GO:0003746 translation elongation factor activity 5/4374 18/18639 0.277777777777778 1.18369913123 0.41996779336849 0.746022344083011 GO:0017075 syntaxin-1 binding 5/4374 18/18639 0.277777777777778 1.18369913123 0.41996779336849 0.746022344083011 GO:0017128 phospholipid scramblase activity 5/4374 18/18639 0.277777777777778 1.18369913123 0.41996779336849 0.746022344083011 GO:0034185 apolipoprotein binding 5/4374 18/18639 0.277777777777778 1.18369913123 0.41996779336849 0.746022344083011 GO:1901611 phosphatidylglycerol binding 5/4374 18/18639 0.277777777777778 1.18369913123 0.41996779336849 0.746022344083011 GO:0005518 collagen binding 18/4374 72/18639 0.25 1.065329218107 0.423901812202205 0.746022344083011 GO:0005161 platelet-derived growth factor receptor binding 4/4374 14/18639 0.285714285714286 1.217519106408 0.424240944111604 0.746022344083011 GO:0005313 L-glutamate transmembrane transporter activity 4/4374 14/18639 0.285714285714286 1.217519106408 0.424240944111604 0.746022344083011 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/4374 14/18639 0.285714285714286 1.217519106408 0.424240944111604 0.746022344083011 GO:0071933 Arp2/3 complex binding 4/4374 14/18639 0.285714285714286 1.217519106408 0.424240944111604 0.746022344083011 GO:1901474 azole transmembrane transporter activity 4/4374 14/18639 0.285714285714286 1.217519106408 0.424240944111604 0.746022344083011 GO:0000182 rDNA binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0004382 GDP phosphatase activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0015203 polyamine transmembrane transporter activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0032395 MHC class II receptor activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0042975 peroxisome proliferator activated receptor binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0045322 unmethylated CpG binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0050815 phosphoserine residue binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0098505 G-rich strand telomeric DNA binding 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0140999 histone H3K4 trimethyltransferase activity 3/4374 10/18639 0.3 1.2783950617284 0.427981239500254 0.746022344083011 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 10/4374 39/18639 0.256410256410256 1.09264535190461 0.43470181738931 0.756745310376678 GO:0098531 ligand-modulated transcription factor activity 15/4374 60/18639 0.25 1.065329218107 0.438614497158502 0.762558537543539 GO:0044325 transmembrane transporter binding 33/4374 136/18639 0.242647058823529 1.03399600580973 0.445823142465344 0.774079346578208 GO:0008017 microtubule binding 66/4374 276/18639 0.239130434782609 1.01901055645017 0.45351947936713 0.78641578560402 GO:0016405 CoA-ligase activity 7/4374 27/18639 0.259259259259259 1.10478585581466 0.454269073156035 0.786689931376988 GO:0160215 deacylase activity 16/4374 65/18639 0.246153846153846 1.04893953782843 0.460969853613517 0.797256053713885 GO:0008171 O-methyltransferase activity 6/4374 23/18639 0.260869565217391 1.11164787976382 0.462283215140278 0.797453535845098 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/4374 23/18639 0.260869565217391 1.11164787976382 0.462283215140278 0.797453535845098 GO:0016836 hydro-lyase activity 15/4374 61/18639 0.245901639344262 1.04786480469541 0.467046403431995 0.80462657586082 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 10/4374 40/18639 0.25 1.065329218107 0.469911482902862 0.807078768727034 GO:0008301 DNA binding, bending 5/4374 19/18639 0.263157894736842 1.12139917695473 0.47150391225632 0.807078768727034 GO:0008381 mechanosensitive monoatomic ion channel activity 5/4374 19/18639 0.263157894736842 1.12139917695473 0.47150391225632 0.807078768727034 GO:0042834 peptidoglycan binding 5/4374 19/18639 0.263157894736842 1.12139917695473 0.47150391225632 0.807078768727034 GO:0046527 glucosyltransferase activity 5/4374 19/18639 0.263157894736842 1.12139917695473 0.47150391225632 0.807078768727034 GO:0016409 palmitoyltransferase activity 9/4374 36/18639 0.25 1.065329218107 0.47782187707777 0.812663806283164 GO:0055106 ubiquitin-protein transferase regulator activity 9/4374 36/18639 0.25 1.065329218107 0.47782187707777 0.812663806283164 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 9/4374 36/18639 0.25 1.065329218107 0.47782187707777 0.812663806283164 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 9/4374 36/18639 0.25 1.065329218107 0.47782187707777 0.812663806283164 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 9/4374 36/18639 0.25 1.065329218107 0.47782187707777 0.812663806283164 GO:0004864 protein phosphatase inhibitor activity 13/4374 53/18639 0.245283018867925 1.04522866682196 0.480413845490484 0.813357731249814 GO:0017081 chloride channel regulator activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0031386 protein tag activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0048531 beta-1,3-galactosyltransferase activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0141047 molecular tag activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0141050 histone H3K deacetylase activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0141051 histone H4K deacetylase activity 4/4374 15/18639 0.266666666666667 1.1363511659808 0.48251071425271 0.813357731249814 GO:0030515 snoRNA binding 8/4374 32/18639 0.25 1.065329218107 0.486600617399569 0.819213697647375 GO:0030165 PDZ domain binding 20/4374 83/18639 0.240963855421687 1.02682334275373 0.488533795539615 0.820309287830123 GO:0042277 peptide binding 59/4374 249/18639 0.236947791164659 1.0097096203745 0.490774710551622 0.820309287830123 GO:0001851 complement component C3b binding 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0003953 NAD+ nucleosidase activity 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0008432 JUN kinase binding 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0034511 U3 snoRNA binding 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0048185 activin binding 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0070990 snRNP binding 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:1990948 ubiquitin ligase inhibitor activity 3/4374 11/18639 0.272727272727273 1.162177328844 0.496452069828432 0.820309287830123 GO:0046875 ephrin receptor binding 7/4374 28/18639 0.25 1.065329218107 0.496502990002443 0.820309287830123 GO:0050698 proteoglycan sulfotransferase activity 7/4374 28/18639 0.25 1.065329218107 0.496502990002443 0.820309287830123 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0005315 phosphate transmembrane transporter activity 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0030215 semaphorin receptor binding 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0048027 mRNA 5'-UTR binding 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0050699 WW domain binding 6/4374 24/18639 0.25 1.065329218107 0.507916093510674 0.832957342008873 GO:0023023 MHC protein complex binding 9/4374 37/18639 0.243243243243243 1.03653653653654 0.514397514059848 0.841511308363589 GO:0070001 aspartic-type peptidase activity 9/4374 37/18639 0.243243243243243 1.03653653653654 0.514397514059848 0.841511308363589 GO:0003779 actin binding 104/4374 443/18639 0.234762979683973 1.00039944634878 0.516934258984529 0.844622315048433 GO:0004713 protein tyrosine kinase activity 33/4374 140/18639 0.235714285714286 1.0044532627866 0.521256493929727 0.84993829404954 GO:0015095 magnesium ion transmembrane transporter activity 5/4374 20/18639 0.25 1.065329218107 0.521465900710094 0.84993829404954 GO:0008514 organic anion transmembrane transporter activity 63/4374 269/18639 0.234200743494424 0.998003579787966 0.531208102046909 0.863119821026848 GO:0001786 phosphatidylserine binding 14/4374 59/18639 0.23728813559322 1.01115993583037 0.531500100316532 0.863119821026848 GO:0004879 nuclear receptor activity 14/4374 59/18639 0.23728813559322 1.01115993583037 0.531500100316532 0.863119821026848 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0004708 MAP kinase kinase activity 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0008142 oxysterol binding 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0015562 efflux transmembrane transporter activity 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0016722 oxidoreductase activity, acting on metal ions 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0031435 mitogen-activated protein kinase kinase kinase binding 4/4374 16/18639 0.25 1.065329218107 0.538257150544008 0.867735769967916 GO:0001848 complement binding 6/4374 25/18639 0.24 1.02271604938272 0.55203206912579 0.879088997314451 GO:0005537 D-mannose binding 6/4374 25/18639 0.24 1.02271604938272 0.55203206912579 0.879088997314451 GO:0015645 fatty acid ligase activity 6/4374 25/18639 0.24 1.02271604938272 0.55203206912579 0.879088997314451 GO:0120515 fatty acid-CoA ligase activity 6/4374 25/18639 0.24 1.02271604938272 0.55203206912579 0.879088997314451 GO:0043495 protein-membrane adaptor activity 11/4374 47/18639 0.234042553191489 0.997329480781018 0.560500041809583 0.879088997314451 GO:0003995 acyl-CoA dehydrogenase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0004000 adenosine deaminase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0005025 transforming growth factor beta receptor activity, type I 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0005026 transforming growth factor beta receptor activity, type II 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0005247 voltage-gated chloride channel activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0015132 prostaglandin transmembrane transporter activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0015166 polyol transmembrane transporter activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0016361 activin receptor activity, type I 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0016362 activin receptor activity, type II 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0016801 hydrolase activity, acting on ether bonds 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0016803 ether hydrolase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0016840 carbon-nitrogen lyase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0017002 activin receptor activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0035251 UDP-glucosyltransferase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0070008 serine-type exopeptidase activity 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0097371 MDM2/MDM4 family protein binding 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/4374 12/18639 0.25 1.065329218107 0.560501856934327 0.879088997314451 GO:0005516 calmodulin binding 48/4374 207/18639 0.231884057971014 0.988131448678953 0.564971467871034 0.885055420810924 GO:0015174 basic amino acid transmembrane transporter activity 5/4374 21/18639 0.238095238095238 1.01459925534 0.569263737292769 0.889056882666177 GO:0019212 phosphatase inhibitor activity 13/4374 56/18639 0.232142857142857 0.989234273956496 0.569531175963596 0.889056882666177 GO:0170055 lipid transmembrane transporter activity 13/4374 56/18639 0.232142857142857 0.989234273956496 0.569531175963596 0.889056882666177 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/4374 30/18639 0.233333333333333 0.994307270233196 0.577341912232741 0.899139043641154 GO:0031210 phosphatidylcholine binding 7/4374 30/18639 0.233333333333333 0.994307270233196 0.577341912232741 0.899139043641154 GO:0005080 protein kinase C binding 12/4374 52/18639 0.230769230769231 0.98338081671415 0.580079848483839 0.902346430974861 GO:0031406 carboxylic acid binding 43/4374 187/18639 0.229946524064171 0.97987500275082 0.589207512192609 0.911510040760073 GO:0004896 cytokine receptor activity 22/4374 96/18639 0.229166666666667 0.976551783264746 0.590173507092682 0.911510040760073 GO:0008429 phosphatidylethanolamine binding 4/4374 17/18639 0.235294117647059 1.00266279351247 0.590768161755777 0.911510040760073 GO:0016018 cyclosporin A binding 4/4374 17/18639 0.235294117647059 1.00266279351247 0.590768161755777 0.911510040760073 GO:0017110 nucleoside diphosphate phosphatase activity 4/4374 17/18639 0.235294117647059 1.00266279351247 0.590768161755777 0.911510040760073 GO:0038191 neuropilin binding 4/4374 17/18639 0.235294117647059 1.00266279351247 0.590768161755777 0.911510040760073 GO:0048038 quinone binding 4/4374 17/18639 0.235294117647059 1.00266279351247 0.590768161755777 0.911510040760073 GO:0097110 scaffold protein binding 16/4374 70/18639 0.228571428571429 0.974015285126396 0.59410398967133 0.915594792888609 GO:0022853 active monoatomic ion transmembrane transporter activity 27/4374 118/18639 0.228813559322034 0.975047080979284 0.595385243563435 0.91650737724464 GO:0046943 carboxylic acid transmembrane transporter activity 43/4374 188/18639 0.228723404255319 0.974662901672358 0.604802302824801 0.929927240181486 GO:0016651 oxidoreductase activity, acting on NAD(P)H 20/4374 88/18639 0.227272727272727 0.968481107369996 0.606192315420713 0.930988198047977 GO:0005246 calcium channel regulator activity 12/4374 53/18639 0.226415094339623 0.964826461681808 0.609250385945309 0.933528817174264 GO:0005544 calcium-dependent phospholipid binding 12/4374 53/18639 0.226415094339623 0.964826461681808 0.609250385945309 0.933528817174264 GO:0008093 cytoskeletal anchor activity 5/4374 22/18639 0.227272727272727 0.968481107369996 0.614452450438167 0.934117389122696 GO:0008970 phospholipase A1 activity 5/4374 22/18639 0.227272727272727 0.968481107369996 0.614452450438167 0.934117389122696 GO:0031683 G-protein beta/gamma-subunit complex binding 5/4374 22/18639 0.227272727272727 0.968481107369996 0.614452450438167 0.934117389122696 GO:0002161 aminoacyl-tRNA editing activity 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0008035 high-density lipoprotein particle binding 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0030955 potassium ion binding 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0043560 insulin receptor substrate binding 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0070123 transforming growth factor beta receptor activity, type III 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0089720 caspase binding 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0140666 annealing activity 3/4374 13/18639 0.230769230769231 0.98338081671415 0.619325742583006 0.934117389122696 GO:0005342 organic acid transmembrane transporter activity 43/4374 189/18639 0.227513227513228 0.969505955102663 0.620169665109279 0.934117389122696 GO:0043177 organic acid binding 43/4374 189/18639 0.227513227513228 0.969505955102663 0.620169665109279 0.934117389122696 GO:0035401 histone H3Y41 kinase activity 26/4374 115/18639 0.226086956521739 0.963428162461979 0.621938882962576 0.934665213943759 GO:0140801 histone H2AXY142 kinase activity 26/4374 115/18639 0.226086956521739 0.963428162461979 0.621938882962576 0.934665213943759 GO:0019842 vitamin binding 34/4374 150/18639 0.226666666666667 0.965898491083676 0.623090189335386 0.935338546067792 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 111/4374 484/18639 0.229338842975207 0.97728548107336 0.627992155374679 0.941634235229226 GO:0004190 aspartic-type endopeptidase activity 8/4374 36/18639 0.222222222222222 0.946959304983996 0.633666259757015 0.947777918213903 GO:0045505 dynein intermediate chain binding 8/4374 36/18639 0.222222222222222 0.946959304983996 0.633666259757015 0.947777918213903 GO:0004683 calcium/calmodulin-dependent protein kinase activity 6/4374 27/18639 0.222222222222222 0.946959304983996 0.634227328729604 0.947777918213903 GO:0042605 peptide antigen binding 10/4374 45/18639 0.222222222222222 0.946959304983996 0.63507104609799 0.947973615387572 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/4374 18/18639 0.222222222222222 0.946959304983996 0.639568267009287 0.95254848277979 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/4374 18/18639 0.222222222222222 0.946959304983996 0.639568267009287 0.95254848277979 GO:0033218 amide binding 56/4374 247/18639 0.226720647773279 0.966128521684077 0.640920753752038 0.953495081085247 GO:0042379 chemokine receptor binding 16/4374 72/18639 0.222222222222222 0.946959304983996 0.643368486093495 0.956067135759049 GO:0030971 receptor tyrosine kinase binding 18/4374 81/18639 0.222222222222222 0.946959304983996 0.646609710911473 0.959811289634218 GO:0048020 CCR chemokine receptor binding 11/4374 50/18639 0.22 0.937489711934156 0.650447026922307 0.964430931780009 GO:0005158 insulin receptor binding 5/4374 23/18639 0.217391304347826 0.926373233136518 0.656721682465359 0.971568228786348 GO:0140103 catalytic activity, acting on a glycoprotein 5/4374 23/18639 0.217391304347826 0.926373233136518 0.656721682465359 0.971568228786348 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 10/4374 46/18639 0.217391304347826 0.926373233136518 0.66465890029331 0.982218152655669 GO:0004065 arylsulfatase activity 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0008195 phosphatidate phosphatase activity 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0016530 metallochaperone activity 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0034236 protein kinase A catalytic subunit binding 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0042813 Wnt receptor activity 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0098821 BMP receptor activity 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:1901612 cardiolipin binding 3/4374 14/18639 0.214285714285714 0.913139329805996 0.672530687620661 0.986180611395236 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 13/4374 60/18639 0.216666666666667 0.923285322359397 0.677436709901223 0.992104595896491 GO:0016597 amino acid binding 11/4374 51/18639 0.215686274509804 0.919107560719761 0.678062464413467 0.992104595896491 GO:0008081 phosphoric diester hydrolase activity 19/4374 87/18639 0.218390804597701 0.930632420415307 0.680207493275842 0.994149413249308 GO:0031420 alkali metal ion binding 4/4374 19/18639 0.210526315789474 0.897119341563786 0.684385428276745 0.994651189788648 GO:0034987 immunoglobulin receptor binding 4/4374 19/18639 0.210526315789474 0.897119341563786 0.684385428276745 0.994651189788648 GO:0042577 lipid phosphatase activity 4/4374 19/18639 0.210526315789474 0.897119341563786 0.684385428276745 0.994651189788648 GO:0043395 heparan sulfate proteoglycan binding 4/4374 19/18639 0.210526315789474 0.897119341563786 0.684385428276745 0.994651189788648 GO:0031491 nucleosome binding 16/4374 74/18639 0.216216216216216 0.921365810254699 0.689409493473076 0.994651189788648 GO:0001216 DNA-binding transcription activator activity 111/4374 491/18639 0.226069246435845 0.963352694174147 0.692475621149318 0.994651189788648 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0004622 lysophospholipase activity 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0005540 hyaluronic acid binding 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0019957 C-C chemokine binding 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0050431 transforming growth factor beta binding 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0070840 dynein complex binding 5/4374 24/18639 0.208333333333333 0.887774348422497 0.695881047979749 0.994651189788648 GO:0033293 monocarboxylic acid binding 17/4374 79/18639 0.215189873417722 0.916992238370579 0.700295538872759 0.994651189788648 GO:0015293 symporter activity 32/4374 146/18639 0.219178082191781 0.933987259710243 0.701609115669385 0.994651189788648 GO:0008238 exopeptidase activity 22/4374 102/18639 0.215686274509804 0.919107560719761 0.711044889583603 0.994651189788648 GO:0099106 ion channel regulator activity 35/4374 160/18639 0.21875 0.932163065843621 0.712121960954703 0.994651189788648 GO:0008235 metalloexopeptidase activity 14/4374 66/18639 0.212121212121212 0.903915700211997 0.712476228670619 0.994651189788648 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0004935 adrenergic receptor activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0005031 tumor necrosis factor receptor activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0015279 store-operated calcium channel activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0016783 sulfurtransferase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0016868 intramolecular phosphotransferase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0031419 cobalamin binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0031434 mitogen-activated protein kinase kinase binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0032052 bile acid binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0035256 G protein-coupled glutamate receptor binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0043121 neurotrophin binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0043208 glycosphingolipid binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0047429 nucleoside triphosphate diphosphatase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0070097 delta-catenin binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0097177 mitochondrial ribosome binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0140135 mechanosensitive monoatomic cation channel activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0140940 histone H2A methyltransferase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:1990259 histone H2AQ104 methyltransferase activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:1990757 ubiquitin ligase activator activity 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:1990763 arrestin family protein binding 2/4374 10/18639 0.2 0.852263374485597 0.719734006696879 0.994651189788648 GO:0004089 carbonate dehydratase activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0010181 FMN binding 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0016846 carbon-sulfur lyase activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0047372 monoacylglycerol lipase activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0050780 dopamine receptor binding 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0140161 monocarboxylate:sodium symporter activity 3/4374 15/18639 0.2 0.852263374485597 0.720035680962648 0.994651189788648 GO:0009055 electron transfer activity 25/4374 116/18639 0.21551724137931 0.918387256988789 0.720856041852017 0.994651189788648 GO:0015294 solute:monoatomic cation symporter activity 25/4374 116/18639 0.21551724137931 0.918387256988789 0.720856041852017 0.994651189788648 GO:0048306 calcium-dependent protein binding 17/4374 80/18639 0.2125 0.905529835390946 0.720935148087411 0.994651189788648 GO:0016408 C-acyltransferase activity 4/4374 20/18639 0.2 0.852263374485597 0.725115310168408 0.998347166173895 GO:0042288 MHC class I protein binding 4/4374 20/18639 0.2 0.852263374485597 0.725115310168408 0.998347166173895 GO:0141108 transporter regulator activity 37/4374 170/18639 0.217647058823529 0.927463083999032 0.728065840895045 1 GO:0008146 sulfotransferase activity 11/4374 53/18639 0.207547169811321 0.884424256541657 0.729257651681824 1 GO:0016758 hexosyltransferase activity 43/4374 197/18639 0.218274111675127 0.930135154895448 0.732818658630749 1 GO:0019205 nucleobase-containing compound kinase activity 9/4374 44/18639 0.204545454545455 0.871632996632997 0.735901572724844 1 GO:0016209 antioxidant activity 18/4374 86/18639 0.209302325581395 0.891903531438415 0.749050209919285 1 GO:0050997 quaternary ammonium group binding 8/4374 40/18639 0.2 0.852263374485597 0.7539253028724 1 GO:0016247 channel regulator activity 36/4374 168/18639 0.214285714285714 0.913139329805996 0.761085551899101 1 GO:0008373 sialyltransferase activity 4/4374 21/18639 0.19047619047619 0.811679404271997 0.761786268492088 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/4374 16/18639 0.1875 0.798996913580247 0.761984572597719 1 GO:0005024 transforming growth factor beta receptor activity 3/4374 16/18639 0.1875 0.798996913580247 0.761984572597719 1 GO:0005159 insulin-like growth factor receptor binding 3/4374 16/18639 0.1875 0.798996913580247 0.761984572597719 1 GO:0017070 U6 snRNA binding 3/4374 16/18639 0.1875 0.798996913580247 0.761984572597719 1 GO:0097027 ubiquitin-protein transferase activator activity 3/4374 16/18639 0.1875 0.798996913580247 0.761984572597719 1 GO:0001637 G protein-coupled chemoattractant receptor activity 5/4374 26/18639 0.192307692307692 0.819484013928458 0.764606789699055 1 GO:0004950 chemokine receptor activity 5/4374 26/18639 0.192307692307692 0.819484013928458 0.764606789699055 1 GO:0005112 Notch binding 5/4374 26/18639 0.192307692307692 0.819484013928458 0.764606789699055 1 GO:0008327 methyl-CpG binding 6/4374 31/18639 0.193548387096774 0.824771007566707 0.768860863955905 1 GO:0016411 acylglycerol O-acyltransferase activity 6/4374 31/18639 0.193548387096774 0.824771007566707 0.768860863955905 1 GO:0002162 dystroglycan binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0005114 type II transforming growth factor beta receptor binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0008172 S-methyltransferase activity 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0008199 ferric iron binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0010854 adenylate cyclase regulator activity 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0019206 nucleoside kinase activity 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0019215 intermediate filament binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0031731 CCR6 chemokine receptor binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0034056 estrogen response element binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0045294 alpha-catenin binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0070697 activin receptor binding 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/4374 11/18639 0.181818181818182 0.774784885895997 0.769352214889867 1 GO:0008374 O-acyltransferase activity 11/4374 55/18639 0.2 0.852263374485597 0.774814167382668 1 GO:0016782 transferase activity, transferring sulphur-containing groups 14/4374 70/18639 0.2 0.852263374485597 0.793603965890975 1 GO:0035255 ionotropic glutamate receptor binding 5/4374 27/18639 0.185185185185185 0.78913275415333 0.794238485373931 1 GO:0004407 histone deacetylase activity 4/4374 22/18639 0.181818181818182 0.774784885895997 0.794527116948515 1 GO:0015377 chloride:monoatomic cation symporter activity 4/4374 22/18639 0.181818181818182 0.774784885895997 0.794527116948515 1 GO:0016881 acid-amino acid ligase activity 4/4374 22/18639 0.181818181818182 0.774784885895997 0.794527116948515 1 GO:0033558 protein lysine deacetylase activity 4/4374 22/18639 0.181818181818182 0.774784885895997 0.794527116948515 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0019198 transmembrane receptor protein phosphatase activity 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0031489 myosin V binding 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0045125 bioactive lipid receptor activity 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0045236 CXCR chemokine receptor binding 3/4374 17/18639 0.176470588235294 0.75199709513435 0.798673803492421 1 GO:0019213 deacetylase activity 7/4374 37/18639 0.189189189189189 0.806195083972862 0.79885094075235 1 GO:0030551 cyclic nucleotide binding 7/4374 37/18639 0.189189189189189 0.806195083972862 0.79885094075235 1 GO:0046982 protein heterodimerization activity 80/4374 369/18639 0.21680216802168 0.923862736569753 0.809945988812334 1 GO:0003720 telomerase activity 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0005078 MAP-kinase scaffold activity 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0005436 sodium:phosphate symporter activity 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0008179 adenylate cyclase binding 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0036009 protein-glutamine N-methyltransferase activity 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0042301 phosphate ion binding 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0045295 gamma-catenin binding 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0070410 co-SMAD binding 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/4374 12/18639 0.166666666666667 0.710219478737997 0.811122286480975 1 GO:0005506 iron ion binding 32/4374 154/18639 0.207792207792208 0.885468441023997 0.811182759695475 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/4374 33/18639 0.181818181818182 0.774784885895997 0.820568190658221 1 GO:0019956 chemokine binding 6/4374 33/18639 0.181818181818182 0.774784885895997 0.820568190658221 1 GO:0030296 protein tyrosine kinase activator activity 6/4374 33/18639 0.181818181818182 0.774784885895997 0.820568190658221 1 GO:0045499 chemorepellent activity 5/4374 28/18639 0.178571428571429 0.760949441504997 0.820858044798953 1 GO:0051959 dynein light intermediate chain binding 5/4374 28/18639 0.178571428571429 0.760949441504997 0.820858044798953 1 GO:0000146 microfilament motor activity 7/4374 38/18639 0.184210526315789 0.784979423868313 0.821708932703153 1 GO:0005283 amino acid:sodium symporter activity 4/4374 23/18639 0.173913043478261 0.741098586509214 0.823538787366022 1 GO:0016493 C-C chemokine receptor activity 4/4374 23/18639 0.173913043478261 0.741098586509214 0.823538787366022 1 GO:0031681 G-protein beta-subunit binding 4/4374 23/18639 0.173913043478261 0.741098586509214 0.823538787366022 1 GO:0072341 modified amino acid binding 18/4374 91/18639 0.197802197802198 0.842897842897843 0.830061307040066 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0031690 adrenergic receptor binding 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0050811 GABA receptor binding 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0070064 proline-rich region binding 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0098641 cadherin binding involved in cell-cell adhesion 3/4374 18/18639 0.166666666666667 0.710219478737997 0.830494910789048 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 11/4374 58/18639 0.189655172413793 0.808180786150135 0.832512820857121 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/4374 34/18639 0.176470588235294 0.75199709513435 0.842747660033226 1 GO:0008013 beta-catenin binding 21/4374 106/18639 0.19811320754717 0.844223153971582 0.842877358829201 1 GO:0003954 NADH dehydrogenase activity 8/4374 44/18639 0.181818181818182 0.774784885895997 0.843262065316825 1 GO:0003785 actin monomer binding 5/4374 29/18639 0.172413793103448 0.734709805591032 0.844623652569609 1 GO:0004629 phospholipase C activity 5/4374 29/18639 0.172413793103448 0.734709805591032 0.844623652569609 1 GO:0005416 amino acid:monoatomic cation symporter activity 5/4374 29/18639 0.172413793103448 0.734709805591032 0.844623652569609 1 GO:0003964 RNA-directed DNA polymerase activity 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0008253 5'-nucleotidase activity 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0031432 titin binding 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0039706 co-receptor binding 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0071837 HMG box domain binding 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:1901338 catecholamine binding 2/4374 13/18639 0.153846153846154 0.655587211142767 0.845994385371515 1 GO:0030246 carbohydrate binding 59/4374 280/18639 0.210714285714286 0.897920340975897 0.847300950786683 1 GO:0015459 potassium channel regulator activity 11/4374 59/18639 0.186440677966102 0.794482806723861 0.849007394679955 1 GO:0030552 cAMP binding 4/4374 24/18639 0.166666666666667 0.710219478737997 0.849070335243276 1 GO:0015171 amino acid transmembrane transporter activity 20/4374 102/18639 0.196078431372549 0.835552327927056 0.85123772530083 1 GO:0019955 cytokine binding 29/4374 144/18639 0.201388888888889 0.858181870141747 0.85241942705282 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 37/4374 181/18639 0.204419889502762 0.871097924197986 0.854346811157245 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0005229 intracellularly calcium-gated chloride channel activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0050145 nucleoside monophosphate kinase activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0070003 threonine-type peptidase activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0141147 intracellularly calcium-gated channel activity 3/4374 19/18639 0.157894736842105 0.672839506172839 0.857890438760105 1 GO:0005343 organic acid:sodium symporter activity 6/4374 35/18639 0.171428571428571 0.730511463844797 0.8626461848768 1 GO:0048019 receptor antagonist activity 5/4374 30/18639 0.166666666666667 0.710219478737997 0.865719696820218 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/4374 25/18639 0.16 0.681810699588477 0.871399295728997 1 GO:0004175 endopeptidase activity 86/4374 405/18639 0.212345679012346 0.904872224762486 0.87164092601299 1 GO:0008191 metalloendopeptidase inhibitor activity 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0008494 translation activator activity 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0031404 chloride ion binding 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0042043 neurexin family protein binding 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0043176 amine binding 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0044548 S100 protein binding 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/4374 14/18639 0.142857142857143 0.608759553203998 0.874905001663324 1 GO:0004180 carboxypeptidase activity 8/4374 46/18639 0.173913043478261 0.741098586509214 0.877120584354281 1 GO:0015026 coreceptor activity 11/4374 61/18639 0.180327868852459 0.768434190109964 0.878158344534113 1 GO:0004812 aminoacyl-tRNA ligase activity 7/4374 41/18639 0.170731707317073 0.72754190504868 0.878174938168883 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/4374 41/18639 0.170731707317073 0.72754190504868 0.878174938168883 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 7/4374 41/18639 0.170731707317073 0.72754190504868 0.878174938168883 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/4374 36/18639 0.166666666666667 0.710219478737997 0.880410534816884 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/4374 20/18639 0.15 0.639197530864198 0.881321343805698 1 GO:0005452 solute:inorganic anion antiporter activity 5/4374 31/18639 0.161290322580645 0.687309172972255 0.884346395447971 1 GO:0047499 calcium-independent phospholipase A2 activity 5/4374 31/18639 0.161290322580645 0.687309172972255 0.884346395447971 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/4374 26/18639 0.153846153846154 0.655587211142767 0.890816115007169 1 GO:0030247 polysaccharide binding 4/4374 26/18639 0.153846153846154 0.655587211142767 0.890816115007169 1 GO:0008252 nucleotidase activity 2/4374 15/18639 0.133333333333333 0.568175582990398 0.898731051001889 1 GO:0031005 filamin binding 2/4374 15/18639 0.133333333333333 0.568175582990398 0.898731051001889 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/4374 32/18639 0.15625 0.665830761316872 0.900711305034007 1 GO:0009975 cyclase activity 3/4374 21/18639 0.142857142857143 0.608759553203998 0.901243856357967 1 GO:0015125 bile acid transmembrane transporter activity 3/4374 21/18639 0.142857142857143 0.608759553203998 0.901243856357967 1 GO:0061891 calcium ion sensor activity 3/4374 21/18639 0.142857142857143 0.608759553203998 0.901243856357967 1 GO:0008194 UDP-glycosyltransferase activity 28/4374 145/18639 0.193103448275862 0.822874982261955 0.902672058099004 1 GO:0015252 proton channel activity 4/4374 27/18639 0.148148148148148 0.631306203322664 0.907612224508602 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/4374 27/18639 0.148148148148148 0.631306203322664 0.907612224508602 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 10/4374 59/18639 0.169491525423729 0.722257097021692 0.91370977410304 1 GO:0070888 E-box binding 10/4374 59/18639 0.169491525423729 0.722257097021692 0.91370977410304 1 GO:0035254 glutamate receptor binding 8/4374 49/18639 0.163265306122449 0.695725203661712 0.916407459068559 1 GO:0015085 calcium ion transmembrane transporter activity 28/4374 147/18639 0.19047619047619 0.811679404271997 0.916843619530767 1 GO:0140784 metal ion sensor activity 3/4374 22/18639 0.136363636363636 0.581088664421998 0.91809386784367 1 GO:0015378 sodium:chloride symporter activity 2/4374 16/18639 0.125 0.532664609053498 0.918266262202485 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/4374 16/18639 0.125 0.532664609053498 0.918266262202485 1 GO:0008527 taste receptor activity 4/4374 28/18639 0.142857142857143 0.608759553203998 0.92207125446021 1 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/4374 39/18639 0.153846153846154 0.655587211142767 0.922468540220998 1 GO:0098632 cell-cell adhesion mediator activity 9/4374 55/18639 0.163636363636364 0.697306397306397 0.924924707827735 1 GO:0004222 metalloendopeptidase activity 20/4374 110/18639 0.181818181818182 0.774784885895997 0.926300059662397 1 GO:0008376 acetylgalactosaminyltransferase activity 5/4374 34/18639 0.147058823529412 0.626664245945292 0.927483767772914 1 GO:0016298 lipase activity 24/4374 130/18639 0.184615384615385 0.78670465337132 0.930420383167051 1 GO:0017022 myosin binding 13/4374 76/18639 0.171052631578947 0.728909465020576 0.930432296765593 1 GO:0001094 TFIID-class transcription factor complex binding 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0004090 carbonyl reductase (NADPH) activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0005131 growth hormone receptor binding 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0005337 nucleoside transmembrane transporter activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0008239 dipeptidyl-peptidase activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0015187 glycine transmembrane transporter activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0015643 toxic substance binding 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0035374 chondroitin sulfate binding 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0042166 acetylcholine binding 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0070739 protein-glutamic acid ligase activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0070740 tubulin-glutamic acid ligase activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0141109 transporter activator activity 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/4374 10/18639 0.1 0.426131687242798 0.931107800528842 1 GO:0005212 structural constituent of eye lens 3/4374 23/18639 0.130434782608696 0.555823939881911 0.932277129915317 1 GO:0016849 phosphorus-oxygen lyase activity 3/4374 23/18639 0.130434782608696 0.555823939881911 0.932277129915317 1 GO:0017134 fibroblast growth factor binding 3/4374 23/18639 0.130434782608696 0.555823939881911 0.932277129915317 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0008569 minus-end-directed microtubule motor activity 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0009881 photoreceptor activity 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0032977 membrane insertase activity 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0070492 oligosaccharide binding 2/4374 17/18639 0.117647058823529 0.501331396756233 0.934211923363827 1 GO:0043236 laminin binding 4/4374 29/18639 0.137931034482759 0.587767844472825 0.934462870762706 1 GO:0008237 metallopeptidase activity 35/4374 184/18639 0.190217391304348 0.810576578994453 0.938202703061419 1 GO:0004623 phospholipase A2 activity 5/4374 35/18639 0.142857142857143 0.608759553203998 0.938290031588933 1 GO:0016229 steroid dehydrogenase activity 5/4374 35/18639 0.142857142857143 0.608759553203998 0.938290031588933 1 GO:0005200 structural constituent of cytoskeleton 20/4374 112/18639 0.178571428571429 0.760949441504997 0.939091600870347 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 22/4374 122/18639 0.180327868852459 0.768434190109964 0.940342315065635 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/4374 132/18639 0.181818181818182 0.774784885895997 0.94178990514363 1 GO:0004601 peroxidase activity 9/4374 57/18639 0.157894736842105 0.672839506172839 0.94218183936127 1 GO:0042287 MHC protein binding 6/4374 41/18639 0.146341463414634 0.623607347184583 0.942713985587192 1 GO:0005253 monoatomic anion channel activity 18/4374 103/18639 0.174757281553398 0.744696152463143 0.944095459046013 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/4374 30/18639 0.133333333333333 0.568175582990398 0.945038743676935 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/4374 68/18639 0.161764705882353 0.689330670539821 0.946349707887782 1 GO:0015373 monoatomic anion:sodium symporter activity 2/4374 18/18639 0.111111111111111 0.473479652491998 0.947176549935674 1 GO:0004016 adenylate cyclase activity 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0008046 axon guidance receptor activity 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0035252 UDP-xylosyltransferase activity 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0042285 xylosyltransferase activity 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0042608 T cell receptor binding 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0048407 platelet-derived growth factor binding 1/4374 11/18639 0.0909090909090909 0.387392442947999 0.947283359092739 1 GO:0005507 copper ion binding 10/4374 63/18639 0.158730158730159 0.676399503559997 0.947681097896221 1 GO:0031492 nucleosomal DNA binding 6/4374 42/18639 0.142857142857143 0.608759553203998 0.950944177406765 1 GO:0042056 chemoattractant activity 6/4374 42/18639 0.142857142857143 0.608759553203998 0.950944177406765 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/4374 31/18639 0.129032258064516 0.549847338377804 0.954030202673818 1 GO:0017147 Wnt-protein binding 4/4374 31/18639 0.129032258064516 0.549847338377804 0.954030202673818 1 GO:0003707 nuclear steroid receptor activity 3/4374 25/18639 0.12 0.511358024691358 0.954086249296575 1 GO:0061134 peptidase regulator activity 43/4374 226/18639 0.190265486725664 0.810781528824793 0.954589748617639 1 GO:0005520 insulin-like growth factor binding 2/4374 19/18639 0.105263157894737 0.448559670781893 0.95768079830927 1 GO:0008574 plus-end-directed microtubule motor activity 2/4374 19/18639 0.105263157894737 0.448559670781893 0.95768079830927 1 GO:0016918 retinal binding 2/4374 19/18639 0.105263157894737 0.448559670781893 0.95768079830927 1 GO:0030506 ankyrin binding 2/4374 19/18639 0.105263157894737 0.448559670781893 0.95768079830927 1 GO:0004032 aldose reductase (NADPH) activity 1/4374 12/18639 0.0833333333333333 0.355109739368999 0.959661638421081 1 GO:0005165 neurotrophin receptor binding 1/4374 12/18639 0.0833333333333333 0.355109739368999 0.959661638421081 1 GO:0010853 cyclase activator activity 1/4374 12/18639 0.0833333333333333 0.355109739368999 0.959661638421081 1 GO:0031543 peptidyl-proline dioxygenase activity 1/4374 12/18639 0.0833333333333333 0.355109739368999 0.959661638421081 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/4374 12/18639 0.0833333333333333 0.355109739368999 0.959661638421081 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/4374 32/18639 0.125 0.532664609053498 0.961647188050934 1 GO:0098631 cell adhesion mediator activity 12/4374 76/18639 0.157894736842105 0.672839506172839 0.962198196341573 1 GO:0030547 signaling receptor inhibitor activity 6/4374 44/18639 0.136363636363636 0.581088664421998 0.964280933268842 1 GO:0001972 retinoic acid binding 2/4374 20/18639 0.1 0.426131687242798 0.966165182143001 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/4374 20/18639 0.1 0.426131687242798 0.966165182143001 1 GO:0010851 cyclase regulator activity 2/4374 20/18639 0.1 0.426131687242798 0.966165182143001 1 GO:0031418 L-ascorbic acid binding 2/4374 20/18639 0.1 0.426131687242798 0.966165182143001 1 GO:0004465 lipoprotein lipase activity 1/4374 13/18639 0.0769230769230769 0.327793605571383 0.969133909508545 1 GO:0005172 vascular endothelial growth factor receptor binding 1/4374 13/18639 0.0769230769230769 0.327793605571383 0.969133909508545 1 GO:0008417 fucosyltransferase activity 1/4374 13/18639 0.0769230769230769 0.327793605571383 0.969133909508545 1 GO:0031994 insulin-like growth factor I binding 1/4374 13/18639 0.0769230769230769 0.327793605571383 0.969133909508545 1 GO:0004620 phospholipase activity 18/4374 109/18639 0.165137614678899 0.703703703703704 0.970507992806131 1 GO:0015370 solute:sodium symporter activity 12/4374 79/18639 0.151898734177215 0.64728863884982 0.974254804907312 1 GO:0005262 calcium channel activity 22/4374 131/18639 0.16793893129771 0.715641001476455 0.97557206586601 1 GO:0015926 glucosidase activity 1/4374 14/18639 0.0714285714285714 0.304379776601999 0.976382287035101 1 GO:0032036 myosin heavy chain binding 1/4374 14/18639 0.0714285714285714 0.304379776601999 0.976382287035101 1 GO:0033038 bitter taste receptor activity 2/4374 22/18639 0.0909090909090909 0.387392442947999 0.978489519716464 1 GO:0004181 metallocarboxypeptidase activity 3/4374 29/18639 0.103448275862069 0.440825883354619 0.979490780836784 1 GO:0004033 aldo-keto reductase (NADPH) activity 4/4374 36/18639 0.111111111111111 0.473479652491998 0.981833703714824 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 4/4374 36/18639 0.111111111111111 0.473479652491998 0.981833703714824 1 GO:0008509 monoatomic anion transmembrane transporter activity 25/4374 149/18639 0.167785234899329 0.714986052420803 0.981903881670939 1 GO:0004129 cytochrome-c oxidase activity 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0005523 tropomyosin binding 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0008020 G protein-coupled photoreceptor activity 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0015250 water channel activity 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0030553 cGMP binding 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0045504 dynein heavy chain binding 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0051371 muscle alpha-actinin binding 1/4374 15/18639 0.0666666666666667 0.284087791495199 0.981928803894616 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/4374 23/18639 0.0869565217391304 0.370549293254607 0.982890699697525 1 GO:0004602 glutathione peroxidase activity 2/4374 23/18639 0.0869565217391304 0.370549293254607 0.982890699697525 1 GO:0033612 receptor serine/threonine kinase binding 3/4374 30/18639 0.1 0.426131687242798 0.983318784965657 1 GO:0022829 wide pore channel activity 4/4374 37/18639 0.108108108108108 0.46068290512735 0.985006123273514 1 GO:0042805 actinin binding 4/4374 37/18639 0.108108108108108 0.46068290512735 0.985006123273514 1 GO:0005178 integrin binding 27/4374 161/18639 0.167701863354037 0.714630779848171 0.985154157429649 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/4374 16/18639 0.0625 0.266332304526749 0.986172973340758 1 GO:0019841 retinol binding 1/4374 16/18639 0.0625 0.266332304526749 0.986172973340758 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/4374 16/18639 0.0625 0.266332304526749 0.986172973340758 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/4374 24/18639 0.0833333333333333 0.355109739368999 0.986411325591076 1 GO:0005109 frizzled binding 4/4374 38/18639 0.105263157894737 0.448559670781893 0.98764743537293 1 GO:0005501 retinoid binding 4/4374 38/18639 0.105263157894737 0.448559670781893 0.98764743537293 1 GO:0019840 isoprenoid binding 4/4374 38/18639 0.105263157894737 0.448559670781893 0.98764743537293 1 GO:0015081 sodium ion transmembrane transporter activity 27/4374 164/18639 0.164634146341463 0.701558265582656 0.989117634661557 1 GO:0005251 delayed rectifier potassium channel activity 2/4374 25/18639 0.08 0.340905349794239 0.989222201790598 1 GO:0004550 nucleoside diphosphate kinase activity 1/4374 17/18639 0.0588235294117647 0.250665698378117 0.989420538964316 1 GO:0015103 inorganic anion transmembrane transporter activity 27/4374 165/18639 0.163636363636364 0.697306397306397 0.990207277150952 1 GO:0043548 phosphatidylinositol 3-kinase binding 2/4374 26/18639 0.0769230769230769 0.327793605571383 0.991462478980795 1 GO:0005372 water transmembrane transporter activity 1/4374 18/18639 0.0555555555555556 0.236739826245999 0.991905479495413 1 GO:0099094 ligand-gated monoatomic cation channel activity 21/4374 136/18639 0.154411764705882 0.657997458242556 0.992123883387962 1 GO:0042562 hormone binding 13/4374 94/18639 0.138297872340426 0.589331056825147 0.992995811923993 1 GO:0004364 glutathione transferase activity 2/4374 27/18639 0.0740740740740741 0.315653101661332 0.993245100748603 1 GO:0008395 steroid hydroxylase activity 2/4374 27/18639 0.0740740740740741 0.315653101661332 0.993245100748603 1 GO:0099589 serotonin receptor activity 1/4374 19/18639 0.0526315789473684 0.224279835390947 0.993806850672421 1 GO:0050840 extracellular matrix binding 8/4374 67/18639 0.119402985074627 0.508813954916774 0.994464519475895 1 GO:0005242 inward rectifier potassium channel activity 2/4374 28/18639 0.0714285714285714 0.304379776601999 0.994661437638962 1 GO:0051393 alpha-actinin binding 2/4374 28/18639 0.0714285714285714 0.304379776601999 0.994661437638962 1 GO:0030627 pre-mRNA 5'-splice site binding 1/4374 20/18639 0.05 0.213065843621399 0.995261675331864 1 GO:0003777 microtubule motor activity 8/4374 68/18639 0.117647058823529 0.501331396756233 0.995316326688153 1 GO:0046906 tetrapyrrole binding 23/4374 152/18639 0.151315789473684 0.644804526748971 0.995905071270196 1 GO:1901681 sulfur compound binding 47/4374 275/18639 0.170909090909091 0.728297792742237 0.996181308677053 1 GO:0020037 heme binding 21/4374 142/18639 0.147887323943662 0.63019474873935 0.996200664621272 1 GO:0098918 structural constituent of synapse 2/4374 30/18639 0.0666666666666667 0.284087791495199 0.996675647496751 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/4374 52/18639 0.0961538461538462 0.409742006964229 0.997135430389802 1 GO:0099186 structural constituent of postsynapse 1/4374 23/18639 0.0434782608695652 0.185274646627304 0.997878116032843 1 GO:0061135 endopeptidase regulator activity 28/4374 184/18639 0.152173913043478 0.648461263195563 0.997907949941856 1 GO:0015106 bicarbonate transmembrane transporter activity 2/4374 32/18639 0.0625 0.266332304526749 0.997937527567543 1 GO:0019838 growth factor binding 19/4374 136/18639 0.139705882352941 0.595331033648027 0.997958501996171 1 GO:0004806 triacylglycerol lipase activity 1/4374 24/18639 0.0416666666666667 0.177554869684499 0.998376672139007 1 GO:0008227 G protein-coupled amine receptor activity 3/4374 41/18639 0.0731707317073171 0.311803673592291 0.998445720122074 1 GO:0005254 chloride channel activity 9/4374 83/18639 0.108433734939759 0.462070504239179 0.998979240673336 1 GO:0005021 vascular endothelial growth factor receptor activity 4/4374 51/18639 0.0784313725490196 0.334220931170822 0.999132071110064 1 GO:0005272 sodium channel activity 4/4374 51/18639 0.0784313725490196 0.334220931170822 0.999132071110064 1 GO:0019199 transmembrane receptor protein kinase activity 8/4374 78/18639 0.102564102564103 0.437058140761844 0.999180332456778 1 GO:0001664 G protein-coupled receptor binding 48/4374 297/18639 0.161616161616162 0.688697676351997 0.999271764993001 1 GO:0005104 fibroblast growth factor receptor binding 1/4374 27/18639 0.037037037037037 0.157826550830666 0.999273196381657 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/4374 60/18639 0.0833333333333333 0.355109739368999 0.999420124605388 1 GO:0008083 growth factor activity 22/4374 162/18639 0.135802469135802 0.578697353045776 0.99943139303736 1 GO:0017046 peptide hormone binding 4/4374 53/18639 0.0754716981132075 0.321608820560603 0.999433517171456 1 GO:0016500 protein-hormone receptor activity 6/4374 67/18639 0.0895522388059701 0.381610466187581 0.999438986573196 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/4374 46/18639 0.0652173913043478 0.277911969940955 0.999495443891757 1 GO:0099095 ligand-gated monoatomic anion channel activity 3/4374 47/18639 0.0638297872340425 0.271998949303914 0.999598187037084 1 GO:0015079 potassium ion transmembrane transporter activity 21/4374 160/18639 0.13125 0.559297839506173 0.999653347487515 1 GO:0005184 neuropeptide hormone activity 1/4374 31/18639 0.032258064516129 0.137461834594451 0.999751115504188 1 GO:0003730 mRNA 3'-UTR binding 39/4374 262/18639 0.148854961832061 0.634318160399585 0.999798485134159 1 GO:0160041 neuropeptide activity 1/4374 32/18639 0.03125 0.133166152263374 0.999809618340854 1 GO:0005539 glycosaminoglycan binding 35/4374 242/18639 0.144628099173554 0.616306159235452 0.999827776527179 1 GO:0004497 monooxygenase activity 11/4374 106/18639 0.10377358490566 0.442212128270829 0.999837741236048 1 GO:0005010 insulin-like growth factor receptor activity 3/4374 51/18639 0.0588235294117647 0.250665698378117 0.999839642941609 1 GO:0005030 neurotrophin receptor activity 3/4374 51/18639 0.0588235294117647 0.250665698378117 0.999839642941609 1 GO:0046873 metal ion transmembrane transporter activity 75/4374 450/18639 0.166666666666667 0.710219478737997 0.99985754316201 1 GO:0005245 voltage-gated calcium channel activity 2/4374 43/18639 0.0465116279069767 0.198200784764092 0.999858072404186 1 GO:0004866 endopeptidase inhibitor activity 20/4374 161/18639 0.124223602484472 0.529356133220867 0.999868166100969 1 GO:0019825 oxygen binding 1/4374 34/18639 0.0294117647058824 0.125332849189058 0.999888606944314 1 GO:0051427 hormone receptor binding 1/4374 34/18639 0.0294117647058824 0.125332849189058 0.999888606944314 1 GO:0015108 chloride transmembrane transporter activity 13/4374 121/18639 0.107438016528926 0.457827432574907 0.999896226023507 1 GO:0038064 collagen receptor activity 3/4374 53/18639 0.0566037735849057 0.241206615420452 0.999899132296664 1 GO:0003735 structural constituent of ribosome 22/4374 175/18639 0.125714285714286 0.535708406819518 0.999909061925973 1 GO:0008201 heparin binding 21/4374 172/18639 0.122093023255814 0.520277060005742 0.999939514838823 1 GO:0015276 ligand-gated monoatomic ion channel activity 23/4374 186/18639 0.123655913978495 0.526937032612062 0.999957980580421 1 GO:0030414 peptidase inhibitor activity 20/4374 169/18639 0.118343195266272 0.504297854725205 0.999960681705258 1 GO:0005004 GPI-linked ephrin receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0005008 hepatocyte growth factor receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0005009 insulin receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0005011 macrophage colony-stimulating factor receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0005020 stem cell factor receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0008288 boss receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0036332 placental growth factor receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0038062 protein tyrosine kinase collagen receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0060175 brain-derived neurotrophic factor receptor activity 2/4374 49/18639 0.0408163265306122 0.173931300915428 0.999967911423096 1 GO:0022834 ligand-gated channel activity 23/4374 188/18639 0.122340425531915 0.521331319499168 0.999968762360789 1 GO:0005125 cytokine activity 31/4374 234/18639 0.132478632478632 0.564533431817382 0.999971412647901 1 GO:0005006 epidermal growth factor receptor activity 2/4374 50/18639 0.04 0.170452674897119 0.999974990187843 1 GO:0005007 fibroblast growth factor receptor activity 2/4374 50/18639 0.04 0.170452674897119 0.999974990187843 1 GO:0005017 platelet-derived growth factor receptor activity 2/4374 50/18639 0.04 0.170452674897119 0.999974990187843 1 GO:0005019 platelet-derived growth factor beta-receptor activity 2/4374 50/18639 0.04 0.170452674897119 0.999974990187843 1 GO:0071855 neuropeptide receptor binding 1/4374 40/18639 0.025 0.1065329218107 0.999977695887873 1 GO:0005003 ephrin receptor activity 2/4374 53/18639 0.0377358490566038 0.160804410280301 0.999988184540957 1 GO:0005005 transmembrane-ephrin receptor activity 2/4374 53/18639 0.0377358490566038 0.160804410280301 0.999988184540957 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/4374 53/18639 0.0377358490566038 0.160804410280301 0.999988184540957 1 GO:0004867 serine-type endopeptidase inhibitor activity 7/4374 95/18639 0.0736842105263158 0.313991769547325 0.999991903014267 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/4374 44/18639 0.0227272727272727 0.0968481107369996 0.999992368804558 1 GO:0017171 serine hydrolase activity 23/4374 198/18639 0.116161616161616 0.495001454877998 0.999993174740875 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/4374 73/18639 0.0547945205479452 0.233496814927561 0.99999335213433 1 GO:0005267 potassium channel activity 11/4374 124/18639 0.0887096774193548 0.37802004513474 0.999993828351284 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/4374 56/18639 0.0357142857142857 0.152189888300999 0.999994434687927 1 GO:0008236 serine-type peptidase activity 21/4374 194/18639 0.108247422680412 0.461276568664885 0.999998093711282 1 GO:0004252 serine-type endopeptidase activity 18/4374 176/18639 0.102272727272727 0.435816498316498 0.999998244204056 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/4374 63/18639 0.0317460317460317 0.135279900711999 0.999999049013798 1 GO:0022835 transmitter-gated channel activity 2/4374 63/18639 0.0317460317460317 0.135279900711999 0.999999049013798 1 GO:0003823 antigen binding 16/4374 174/18639 0.0919540229885057 0.39184522964855 0.999999737011913 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/4374 69/18639 0.0289855072463768 0.123516431084869 0.999999792852926 1 GO:0005249 voltage-gated potassium channel activity 5/4374 98/18639 0.0510204081632653 0.217414126144285 0.999999855592419 1 GO:0022832 voltage-gated channel activity 15/4374 175/18639 0.0857142857142857 0.365255731922399 0.99999993583866 1 GO:0001653 peptide receptor activity 8/4374 128/18639 0.0625 0.266332304526749 0.999999963126645 1 GO:0005244 voltage-gated monoatomic ion channel activity 14/4374 173/18639 0.0809248554913295 0.344846452103999 0.999999974298683 1 GO:0005261 monoatomic cation channel activity 40/4374 341/18639 0.117302052785924 0.499861216707095 0.999999990561804 1 GO:0022836 gated channel activity 36/4374 318/18639 0.113207547169811 0.482413230840904 0.999999991383296 1 GO:0008528 G protein-coupled peptide receptor activity 6/4374 122/18639 0.0491803278688525 0.209572960939081 0.999999995969314 1 GO:0005216 monoatomic ion channel activity 57/4374 448/18639 0.127232142857143 0.54217647707231 0.999999997607738 1 GO:0030594 neurotransmitter receptor activity 3/4374 97/18639 0.0309278350515464 0.131793305332824 0.999999997621951 1 GO:0022843 voltage-gated monoatomic cation channel activity 8/4374 143/18639 0.0559440559440559 0.238395349506461 0.999999998595125 1 GO:0005179 hormone activity 5/4374 132/18639 0.0378787878787879 0.161413517894999 0.999999999950521 1 GO:0030527 structural constituent of chromatin 1/4374 98/18639 0.0102040816326531 0.043482825228857 0.999999999996171 1 GO:0005201 extracellular matrix structural constituent 6/4374 168/18639 0.0357142857142857 0.152189888300999 0.999999999999919 1 GO:0004984 olfactory receptor activity 1/4374 419/18639 0.00238663484486874 0.0101702073327637 1 1 GO:0030371 translation repressor activity 12/4374 329/18639 0.0364741641337386 0.155427971030808 1 1 GO:0045182 translation regulator activity 14/4374 356/18639 0.0393258426966292 0.167579877005595 1 1