category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/845	205/9376	2.32742387068841	COL3A1/COL1A2/PDK4/PTEN/TGFB3/COL1A1/SDHD/SLC2A4/PPP1CB/CAMK2D/PLN/IRS1/NFKB1/AGTR1/NDUFB3/NDUFA4L2/VDAC3/PDHB/TGFBR2/PRKCA/COX4I2/PRKCD/PIK3CA/NDUFA5/ATP5MC3/NDUFV2/RYR2/NDUFB8/NDUFB6/GFPT2/NDUFC2/ATP2A2/NDUFA4/PIK3R1/PIK3R3/MPC2/NDUFB5/UQCRFS1/PPIF/NDUFA7/VDAC2/SDHC/VDAC1	6.04772769895133
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	44/845	216/9376	2.26026736795968	HSPA1A/SOD2/VCAM1/HSPA1B/NFKBIA/HSPA8/CXCL1/NFATC1/HSPA5/HSP90AB1/CXCL2/CALM2/HSP90AA1/HSPD1/CAMK2D/FAS/ERN1/CASP7/DDIT3/BCL2/JUN/NFKB1/KRAS/IRF7/CASP3/CYCS/CXCL8/HSPA4/PRKCA/PPP3CC/PIK3CA/RAP1B/TBK1/TNFRSF10B/TICAM1/TNFRSF1A/TANK/EIF2S1/CXCL3/CDC42/PIK3R1/PIK3R3/FOS/CD40	5.89733571915777
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	46/845	233/9376	2.19059857277091	VIM/SYNPO2/COL3A1/COL1A2/COL5A2/ITGA7/ATP1B2/DAAM2/SGCB/THBS2/COL1A1/TPM4/COL5A3/TMOD1/LAMA2/PDLIM3/SDC2/MYH11/ACTG1/LBR/TMOD2/PDLIM1/COL6A1/ACTG2/COL6A2/ITGA11/SSPN/THBS1/SGCE/ELN/VCL/THBS3/SNTB2/CAPZA2/TPM2/FHL1/CSRP2/ITGB5/SGCA/LDB3/LMOD1/NID1/PDLIM7/COL4A1/ITGA6/DES	5.79179230984049
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	59/845	333/9376	1.96593279670203	COL1A2/HEYL/JAG1/ITGA7/WNT6/CDKN1B/MX1/PTEN/HEY2/CCND2/THBS2/COL1A1/FZD10/LAMA2/HES4/NOTCH1/FAS/DLG3/COL6A1/HES1/HLA-B/PDGFRB/NOTCH3/COL6A2/PARD6G/ITGA11/ISG15/LAMB1/NFKB1/HLA-F/KRAS/WNT3A/THBS1/CASP3/OASL/ATP6V1G1/THBS3/HES6/ITGB5/GNAS/PIK3CA/LLGL1/MX2/DLG2/TBK1/FZD3/COL4A1/MAML2/TICAM1/ITGA6/TNFRSF1A/SOS1/STAT2/CDC42/PIK3R1/PIK3R3/TLR3/FZD7/WNT2	5.64841743793401
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/845	224/9376	2.13000845308538	ZFP36/NRP1/ADCY3/MSX1/NFKBIA/MYC/NFATC1/PTEN/TGFB3/FOSL1/ADCY6/CCND2/B2M/CALR/HLA-B/IL15RA/CDKN2C/JUN/NFKB1/HLA-F/KRAS/RAN/VDAC3/TGFBR2/JAK3/PPP3CC/ELK4/PIK3CA/ANAPC10/HLA-DOB/PTTG1/ETS1/NFYB/TNFRSF1A/EGR1/PIK3R1/XPO1/PIK3R3/ADCY4/VDAC2/FOS/VDAC1/CD40	5.38718286140144
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/845	227/9376	2.10185856163491	SOD2/HGF/NFKBIA/CAT/PTEN/GSTM3/SDHD/JUN/NFKB1/EPHX1/KRAS/NDUFB3/NDUFA4L2/VDAC3/ABL1/HIF1A/EPHX2/COX4I2/PRKCD/PIK3CA/NDUFA5/ATP5MC3/NDUFV2/SOD1/NDUFB8/SOS1/NDUFB6/CBR1/NDUFC2/NDUFA4/GSTM4/PIK3R1/PIK3R3/NDUFB5/AHR/GSTT2B/UQCRFS1/PPIF/NDUFA7/VDAC2/FOS/SDHC/VDAC1	5.28890768914049
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	52/845	300/9376	1.92328205128205	HSPA1A/HGF/CACNA2D1/HSPA1B/PDGFA/MYC/HSPA8/DUSP1/NFATC1/TGFB3/NGF/CACNA1H/GADD45A/CSF1/KITLG/DUSP8/FAS/ANGPT1/PDGFRB/FGF2/DDIT3/JUN/JUND/NFKB1/KRAS/MAP3K13/MEF2C/CASP3/NR4A1/FGF7/MAP3K20/EPHA2/TGFBR2/MAP3K12/PRKCA/PPP3CC/ELK4/RRAS/RAP1B/NTRK2/NGFR/CACNB2/MAP3K8/TNFRSF1A/SOS1/NTF3/MAX/MAPT/MAPKAPK2/GADD45B/CDC42/FOS	5.11519033514219
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/845	166/9376	2.27264561203393	GUCY1A2/PDE3A/PDE5A/MYLK/PRKG1/GUCY1B1/ADCY3/KCNJ8/GUCY1A1/ATP1B2/TRPC6/NFATC1/ADCY6/CALM2/PPP1CB/EDNRA/ADRA2A/PLN/IRS1/GNAI3/MEF2C/AGTR1/VDAC3/ADRA2C/EDNRB/RGS2/PPP3CC/KCNMB1/MEF2D/ATP2A2/ADCY4/PPIF/VDAC2/VDAC1	5.20649834951066
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/845	196/9376	2.1512377732158	ZFP36/NFKBIA/MYC/CXCL1/NFATC1/CXCL2/CALM2/GNB4/CLEC2B/FAS/HLA-B/FGF2/JUN/IFNGR1/NFKB1/HLA-F/KRAS/IRF7/CASP3/CYCS/UBB/CXCL8/MAP1LC3B/HIF1A/PPP3CC/PIK3CA/TBK1/TICAM1/TNFRSF1A/MAPKAPK2/CXCL3/GNG11/STAT2/PIK3R1/PIK3R3/TLR3/FOS/MICB	5.12608434183892
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	23/845	93/9376	2.74413692180442	RARB/NFKBIA/MYC/CDKN1B/PTEN/GADD45A/LAMA2/CKS2/BCL2/LAMB1/NFKB1/TRAF1/CASP3/CYCS/PIK3CA/POLK/COL4A1/ITGA6/MAX/GADD45B/PIK3R1/PIK3R3/BIRC2	5.319758247566
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/845	101/9376	2.63663952194036	COL3A1/COL1A2/VCAM1/F3/CDKN1B/NFATC1/TGFB3/COL1A1/BCL2/JUN/NFKB1/KRAS/AGTR1/CASP3/CXCL8/TGFBR2/PRKCA/PRKCD/PIK3CA/COL4A1/EGR1/CDC42/PIK3R1/PIK3R3	5.20440138597075
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	38/845	201/9376	2.09772439577262	RUNX1T1/PDGFA/MYC/CDKN1B/MLF1/IGFBP3/CCND2/GADD45A/HOXA10/DDX5/CDK14/PBX1/DDIT3/PLAU/CDKN2C/NFKB1/PLAT/ETV7/MEF2C/TRAF1/HOXA11/CEBPB/CXCL8/SIN3A/BCL6/TGFBR2/ETV1/NFKBIZ/ELK4/NGFR/MEIS1/POLK/RARA/MAX/GADD45B/ETV6/BIRC2/CD40	4.95110720388124
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	32/845	157/9376	2.26157615045415	SDHD/FAS/ERN1/CASP7/DDIT3/SOCS3/IRS1/JUN/NFKB1/CASP3/NDUFB3/CYCS/CXCL8/NDUFA4L2/COX4I2/PIK3CA/NDUFA5/NDUFV2/NDUFB8/TNFRSF1A/NDUFB6/EIF2S1/NDUFC2/CDC42/NDUFA4/PIK3R1/PIK3R3/NDUFB5/UQCRFS1/NDUFA7/FOS/SDHC	5.01689960932251
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/845	136/9376	2.36602854159415	HSPA1A/HSPA1B/NFKBIA/OAS1/HSPA8/CDKN1B/MX1/OAS2/CCND2/FAS/BBC3/BCL2/JUN/NFKB1/IRF7/CASP3/CYCS/MSN/JAK3/RAB9A/PIK3CA/MX2/TBK1/EIF2S1/STAT2/PIK3R1/PIK3R3/RCHY1/FOS	5.05018472289636
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	29/845	137/9376	2.34875826026865	NFKBIA/NGF/GADD45A/PMAIP1/ACTG1/FAS/BBC3/ERN1/CASP7/DDIT3/BCL2/JUN/NFKB1/KRAS/TUBA1A/TRAF1/CASP3/CYCS/CTSC/PIK3CA/MCL1/TNFRSF10B/TNFRSF1A/EIF2S1/GADD45B/PIK3R1/PIK3R3/FOS/BIRC2	5.00490616170802
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	38/845	204/9376	2.06687550759949	TWIST1/COL1A2/HGF/WNT6/MYC/COL1A1/FZD10/SDC2/PPP1CB/CAMK2D/ACTG1/LUM/FAS/DDX5/FGF2/HOXD10/PLAU/KRAS/WNT3A/THBS1/HSPB2/CASP3/MSN/ESR1/HIF1A/PRKCA/ITGB5/ARHGEF12/PIK3CA/RRAS/FZD3/SOS1/GPC3/CDC42/PIK3R1/PIK3R3/FZD7/WNT2	4.84853826530011
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/845	275/9376	1.89638300161377	HSPA1A/C7/HSPA1B/HSPA8/HSPA5/SDHD/NOTCH1/DDIT3/STIP1/PSMA2/TUBA1A/CASP3/NDUFB3/CYCS/NDUFA4L2/VDAC3/PSMA3/PPP3CC/COX4I2/PRKCD/PIK3CA/NDUFA5/ATP5MC3/NDUFV2/SOD1/PSMD11/RYR2/NDUFB8/NDUFB6/EGR1/EIF2S1/PSMD12/PSMA1/NDUFC2/PRNP/NDUFA4/PIK3R1/PIK3R3/NDUFB5/UQCRFS1/PPIF/PSMA5/KIF5C/NDUFA7/VDAC2/SDHC/VDAC1	4.74820459220466
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	24/845	105/9376	2.53619611158073	ADCY3/ITGA7/CACNA2D1/SGCB/TGFB3/ADCY6/TPM4/LAMA2/ACTG1/PLN/ITGA11/SSPN/SGCE/SNTB2/TPM2/ITGB5/SGCA/GNAS/RYR2/CACNB2/ITGA6/ATP2A2/DES/ADCY4	4.9818660032631
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/845	119/9376	2.42430510665805	JAG1/VCAM1/NFKBIA/CXCL1/CXCL2/CSF1/LIF/JUNB/FAS/CASP7/SOCS3/JUN/NFKB1/TRAF1/CASP3/CEBPB/CYLD/PIK3CA/MAP3K8/TNFRSF1A/CXCL3/IL18R1/PIK3R1/PIK3R3/FOS/BIRC2	4.92102308010887
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	35/845	187/9376	2.07676486409518	NFKBIA/OAS1/CXCL1/OAS2/HSP90AB1/CXCL2/RIPK2/TXN/HSP90AA1/IFI16/GBP1/TXNIP/NLRP1/BCL2/JUN/GBP2/NFKB1/IRF7/CXCL8/VDAC3/MAP1LC3B/TRPV2/PRKCD/TBK1/TRIP6/NAMPT/TICAM1/TANK/CXCL3/GABARAPL2/STAT2/VDAC2/BIRC2/ANTXR1/VDAC1	4.6808160564728
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/845	173/9376	2.11655094571947	NFKBIA/OAS1/MX1/OAS2/ACTG1/CALCOCO2/FAS/RSAD2/SOCS3/IFNGR1/NFKB1/IRF7/CASP3/CYCS/CXCL8/NXT1/KPNA2/PRKCA/PIK3CA/HLA-DOB/MX2/TBK1/TNFRSF10B/TICAM1/TNFRSF1A/EIF2S1/STAT2/PIK3R1/XPO1/PIK3R3/NUP98/TLR3/VDAC1	4.6649920287979
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	45/845	268/9376	1.86311048308752	DUSP1/HSPA5/SDHD/CALM2/TXN/CAMK2D/ERN1/DDIT3/GNAI3/SLC39A14/PSMA2/TUBA1A/CASP3/NDUFB3/CYCS/UBB/NDUFA4L2/VDAC3/UBE2L6/PSMA3/UCHL1/COX4I2/GNAS/NDUFA5/ATP5MC3/NDUFV2/SOD1/PSMD11/NDUFB8/NDUFB6/EIF2S1/PSMD12/MAPT/PSMA1/NDUFC2/NDUFA4/NDUFB5/UQCRFS1/PPIF/PSMA5/KIF5C/NDUFA7/VDAC2/SDHC/VDAC1	4.51165933040396
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/845	205/9376	2.00266705152259	VIM/NFKBIE/NFKBIA/MYC/OAS1/CDKN1B/SAP30/OAS2/CCND2/B2M/GADD45A/FAS/CALR/HES1/HLA-B/BCL2/JUN/ISG15/NFKB1/HLA-F/IRF7/CASP3/CYCS/SIN3A/JAK3/PIK3CA/HLA-DOB/PSMD11/TBK1/POLK/PSMD12/GADD45B/NEDD4/STAT2/PIK3R1/PIK3R3/CD40	4.56813941214892
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	29/845	148/9376	2.174188389573	HEYL/JAG1/WNT6/MYC/PTEN/HEY2/FZD10/GADD45A/NOTCH1/HES1/NOTCH3/FGF2/JUN/PGR/KRAS/WNT3A/FGF7/ESR1/PIK3CA/POLK/FZD3/SOS1/GADD45B/PIK3R1/DLL1/PIK3R3/FZD7/FOS/WNT2	4.53136314631872
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/845	120/9376	2.31163708086785	NFKBIE/NFKBIA/NGF/CALM2/RIPK2/CAMK2D/IRS1/BCL2/JUN/NFKB1/KRAS/ABL1/PRKCD/PIK3CA/RAP1B/NTRK2/NGFR/IRAK3/SOS1/NTF3/MAPKAPK2/CDC42/PIK3R1/PIK3R3/SORT1	4.55099813694831
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/845	203/9376	1.96773836243332	COL1A2/MYLK/HGF/ITGA7/PDGFA/PTEN/CCND2/THBS2/COL1A1/LAMA2/PPP1CB/ACTG1/COL6A1/PDGFRB/COL6A2/ITGA11/BCL2/JUN/LAMB1/THBS1/MYL12B/EMP2/VCL/THBS3/PRKCA/MYL12A/ITGB5/PIK3CA/RAP1B/COL4A1/ITGA6/SOS1/CDC42/PIK3R1/PIK3R3/BIRC2	4.38696633097241
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	33/845	180/9376	2.03424063116371	NFKBIA/OAS1/OAS2/B2M/SRSF7/PPP1CB/FAS/CALR/HLA-B/CGAS/SOCS3/BCL2/IFNGR1/NFKB1/HLA-F/IRF7/CASP3/CYCS/EIF2B2/PIK3CA/HLA-DOB/SRSF1/TBK1/SRSF2/TICAM1/TNFRSF1A/EIF2S1/STAT2/PIK3R1/PIK3R3/SRSF9/TLR3/BIRC2	4.40932781917489
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/845	56/9376	2.97210481825866	HSPA1A/HSPA1B/NFKBIA/HSPA8/CXCL1/CXCL2/HSPD1/SEC22B/CASP7/NFKB1/CASP3/CYCS/CLK4/CXCL8/CXCL3	4.65832809197196
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/845	139/9376	2.15531054446384	HSPA1A/ADCY3/HSPA1B/HSPA8/FKBP4/ADCY6/HSP90AB1/CALM2/HSP90AA1/FKBP5/BCL2/JUN/GNAI3/PGR/KRAS/GABBR1/ESR1/GNAS/PRKCD/PIK3CA/KRT17/RARA/SOS1/PIK3R1/PIK3R3/ADCY4/FOS	4.3187164126901
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	57/845	388/9376	1.63006161166351	WNT6/FZD10/SDHD/PPID/CALM2/CSF1/FAS/ERN1/CASP7/DDIT3/IRS1/SLC39A14/NFKB1/PSMA2/KRAS/LPL/WNT3A/TUBA1A/CASP3/NDUFB3/CYCS/NDUFA4L2/VDAC3/PSMA3/PPP3CC/COX4I2/PIK3CA/NDUFA5/ATP5MC3/NDUFV2/PSMD11/MME/FZD3/NDUFB8/TNFRSF1A/NDUFB6/EIF2S1/PSMD12/MAPT/PSMA1/NDUFC2/ATP2A2/NDUFA4/PIK3R1/PIK3R3/NDUFB5/BACE1/UQCRFS1/PPIF/PSMA5/FZD7/KIF5C/NDUFA7/VDAC2/SDHC/VDAC1/WNT2	3.98915923525159
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/845	157/9376	2.04955338634907	MYC/NFATC1/PTEN/IGFBP3/TGFB3/CCND2/PPID/GADD45A/CALM2/PPP1CB/HLA-B/NFKB1/HLA-F/KRAS/SIRT1/ZFP36L1/CXCL8/VDAC3/TGFBR2/PPP3CC/PIK3CA/RRAS/ETS1/MAPKAPK2/GADD45B/PIK3R1/PIK3R3/VDAC2/VDAC1	4.17375040899614
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	67/845	480/9376	1.54879684418146	WNT6/CAT/IFT57/HSPA5/FZD10/SDHD/PPID/CALM2/CSF1/CAMK2D/FAS/ERN1/CASP7/DDIT3/BCL2/NFKB1/PSMA2/KRAS/WNT3A/TUBA1A/CASP3/NDUFB3/CYCS/UBB/NDUFA4L2/VDAC3/MAP1LC3B/UBE2L6/PSMA3/PRKCA/PPP3CC/UCHL1/COX4I2/NDUFA5/ATP5MC3/NDUFV2/SOD1/PSMD11/RYR2/ACTR10/TBK1/FZD3/C9orf72/NDUFB8/TNFRSF1A/TANK/NDUFB6/EIF2S1/PSMD12/MAPT/PSMA1/NDUFC2/PRNP/ATP2A2/NDUFA4/NDUFB5/UQCRFS1/HAP1/PPIF/PSMA5/FZD7/KIF5C/NDUFA7/VDAC2/SDHC/VDAC1/WNT2	3.88462283354479
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	32/845	184/9376	1.92971443272447	NRP1/ENAH/TRPC4/SLIT3/TRPC6/EPHA3/UNC5C/EPHB6/CAMK2D/TRPC1/PARD6G/GNAI3/KRAS/NCK2/MYL12B/ABL1/EPHA2/PRKCA/MYL12A/ROBO1/PPP3CC/NEO1/ARHGEF12/PIK3CA/RRAS/CXCL12/FZD3/CDC42/PIK3R1/CFL2/PIK3R3/NTN1	4.00836718699998
NA	NA	hsa04518	Integrin signaling	28/845	154/9376	2.01742872512103	COL1A2/HGF/ITGA7/VCAM1/PDGFA/CCND2/THBS2/COL1A1/LAMA2/ACTG1/COL6A1/PDGFRB/COL6A2/ITGA11/LAMB1/NCK2/THBS1/VCL/THBS3/ITGB5/PIK3CA/ARHGEF6/COL4A1/ITGA6/CDC42/PIK3R1/PIK3R3/ITGAE	4.00650619041193
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/845	62/9376	2.68448177133041	HSPA1A/SOD2/ADCY3/HSPA1B/HSPA8/CAT/ADCY6/IRS1/KRAS/SIRT1/PIK3CA/SOD1/PIK3R1/PIK3R3/ADCY4	4.18801342582781
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/845	157/9376	1.97887913164738	SNAI2/WNT6/TP53BP2/MYC/TGFB3/CCND2/FZD10/BMP5/BMP2/PPP1CB/ACTG1/BBC3/DLG3/TEAD2/PARD6G/WNT3A/YAP1/SAV1/SMAD7/TGFBR2/LLGL1/RASSF1/DLG2/FZD3/YWHAQ/FZD7/BIRC2/WNT2	3.89270067555401
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/845	134/9376	2.07012275898613	GUCY1A2/AVPR1A/MYLK/PRKG1/GUCY1B1/ADCY3/PPP1R14A/GUCY1A1/ADCY6/CALM2/PPP1CB/MYH11/ACTG2/EDNRA/PLA2G2A/ACTA2/AGTR1/PRKCA/PTGIR/ARHGEF12/GNAS/PRKCD/CALCRL/KCNMB1/ADCY4	3.92660340962087
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	38/845	238/9376	1.77160757794242	C7/NRP1/RPS7/ACE2/NFKBIA/OAS1/MX1/OAS2/RPL22L1/CGAS/C1S/JUN/ISG15/NFKB1/AGTR1/C1R/CXCL8/RPL32/RPL36A/RPS21/RPS10/PRKCA/RPS15A/RPL7A/PIK3CA/RPL26/MX2/CFD/TBK1/TNFRSF1A/RPS18/STAT2/PIK3R1/PIK3R3/RPL30/TLR3/RPS23/FOS	3.7946647024554
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	39/845	248/9376	1.74491315136476	NFKBIA/MYC/WASF3/HSP90AB1/SKP1/DYNLL1/RIPK2/TXN/HSP90AA1/ACTG1/RHOB/CASP7/BCL2/JUN/NFKB1/DYNLT3/MYL12B/TUBA1A/CASP3/CYCS/CXCL8/RAB9A/MYL12A/EXOC2/PIK3CA/RRAS/DYNC2LI1/DYNC1I1/ACTR10/TNFRSF10B/DYNC2H1/TNFRSF1A/EXOC5/CDC42/KIF5C/FOS/BIRC2/KPNA4/ACTR3	3.74160285401208
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	35/845	217/9376	1.78965451422027	ADCY3/JAG1/MYC/AR/ADCY6/GSTM3/HSP90AB1/PTGES3/HSP90AA1/FGF2/BCL2/JUN/GNAI3/NFKB1/PGR/EPHX1/KRAS/FGF7/BCL6/KPNA2/ESR1/PRKCA/EPHX2/GNAS/PIK3CA/SOS1/GSTM4/PIK3R1/DLL1/PIK3R3/AHR/GSTT2B/ADCY4/FOS/KPNA4	3.70388062934318
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/845	130/9376	2.04846609012289	COL3A1/COL1A2/ADCY3/NFKBIA/ADCY6/COL1A1/GNB4/JUN/GNAI3/NFKB1/KRAS/ACTA2/TGFBR2/EDNRB/PRKCA/GNAS/PIK3CA/COL4A1/SOS1/GNG11/PIK3R1/PIK3R3/ADCY4/FOS	3.78846380379019
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/845	163/9376	1.90603695502233	NFKBIA/MYC/NFATC1/TGFB3/EGR3/FAS/BCL2/JUN/NFKB1/KRAS/IRF7/CASP3/CYCS/CXCL8/VDAC3/TGFBR2/JAK3/PRKCA/PIK3CA/TBK1/YWHAQ/TICAM1/SOS1/STAT2/PIK3R1/PIK3R3/TLR3/FOS	3.67242724064915
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/845	87/9376	2.29569475617221	MYC/TGFB3/GADD45A/PMAIP1/BBC3/BCL2/JUN/KRAS/CASP3/CYCS/TGFBR2/PIK3CA/POLK/SOS1/GADD45B/PIK3R1/PIK3R3/FOS	3.82113047927696
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/845	47/9376	2.83298501825507	ADH1B/LDHB/ALDH3A2/ADH5/PDHB/ACSS2/ME3/MDH1/FH/ACYP1/ACAT1/ACYP2	3.96464512224694
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/845	103/9376	2.15453553168266	COL3A1/COL1A2/CXCL1/TGFB3/COL1A1/CXCL2/LAMA2/LAMB1/NFKB1/ARG2/CASP3/CXCL8/VCL/PRKCA/GNAS/PIK3CA/COL4A1/CXCL3/PIK3R1/PIK3R3	3.70791532017811
Organismal Systems	Immune system	hsa04611	Platelet activation	23/845	126/9376	2.02543439466516	COL3A1/GUCY1A2/COL1A2/MYLK/PRKG1/GUCY1B1/ADCY3/GUCY1A1/ADCY6/COL1A1/PPP1CB/ACTG1/GNAI3/MYL12B/MYL12A/PTGIR/ARHGEF12/GNAS/PIK3CA/RAP1B/PIK3R1/PIK3R3/ADCY4	3.64700457525733
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/845	142/9376	1.95349612467706	VCAM1/PDGFA/DUSP1/GSTM3/HSP90AB1/CALM2/SDC2/TXN/HSP90AA1/ACTG1/KLF2/BCL2/SUMO2/JUN/NFKB1/PLAT/MEF2C/SUMO1/PIK3CA/TNFRSF1A/GSTM4/PIK3R1/PIK3R3/GSTT2B/FOS	3.60314874529165
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/845	75/9376	2.36711637080868	PTEN/IGFBP3/CCND2/GADD45A/PMAIP1/FAS/BBC3/BCL2/THBS1/CASP3/CYCS/SIAH1/CCNG1/TNFRSF10B/GADD45B/RCHY1	3.74097938584554
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	20/845	105/9376	2.11349675965061	VCAM1/NFKBIA/CXCL1/CXCL2/GADD45A/EDA/PLAU/BCL2/NFKB1/TRAF1/CXCL8/BCL10/CYLD/CXCL12/TICAM1/TNFRSF1A/CXCL3/GADD45B/BIRC2/CD40	3.61105695414037
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	19/845	99/9376	2.12950809873887	ADCY3/JAG1/CDKN1B/ADCY6/NOTCH1/NOTCH3/CDKN2C/BCL2/JUN/KRAS/ESR1/GNAS/PIK3CA/SOS1/PIK3R1/DLL1/PIK3R3/ADCY4/FOS	3.555635142292
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/845	99/9376	2.12950809873887	ITGA7/CACNA2D1/SGCB/TGFB3/TPM4/LAMA2/ACTG1/ITGA11/SSPN/SGCE/SNTB2/TPM2/ITGB5/SGCA/RYR2/CACNB2/ITGA6/ATP2A2/DES	3.555635142292
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	50/845	362/9376	1.53257707018863	COL1A2/HGF/ITGA7/PDGFA/MYC/CDKN1B/PTEN/NGF/CCND2/THBS2/COL1A1/HSP90AB1/CSF1/KITLG/LAMA2/GHR/GNB4/HSP90AA1/COL6A1/ANGPT1/PDGFRB/FGF2/COL6A2/ITGA11/IRS1/BCL2/LAMB1/NFKB1/KRAS/THBS1/NR4A1/FGF7/EPHA2/EIF4E/THBS3/JAK3/PRKCA/ITGB5/PIK3CA/MCL1/NTRK2/NGFR/YWHAQ/COL4A1/ITGA6/SOS1/NTF3/GNG11/PIK3R1/PIK3R3	3.25231044788478
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/845	156/9376	1.84930966469428	IFIT1/NFKBIA/MYC/OAS1/MX1/OAS2/FAS/RSAD2/SOCS3/NFKB1/KRAS/IRF7/CASP3/CYCS/PIK3CA/MX2/TBK1/YWHAQ/TICAM1/TNFRSF1A/SOS1/EIF2S1/STAT2/PIK3R1/PIK3R3/TLR3	3.36648688188222
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/845	32/9376	3.1207100591716	PMAIP1/BBC3/CASP7/BCL2/CASP3/CYCS/NGFR/TNFRSF1A/BIRC2	3.78184645562202
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/845	174/9376	1.78554036591172	HSPA1A/BAG2/DNAJA1/HSPA1B/HSPA8/HSPA5/HSP90AB1/SKP1/HSP90AA1/CALR/HSPH1/SEC61B/ERN1/HSPA4L/DDIT3/ERO1B/BCL2/HERPUD1/DNAJB11/SEC61G/OSTC/PDIA6/UBE2D1/DNAJA2/EIF2S1/UBQLN2/PPP1R15A/MAN1A1	3.29166809518141
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	19/845	103/9376	2.04680875509852	COL15A1/COL3A1/COL1A2/COL5A2/ACE2/ATP1B2/COL1A1/COL5A3/COL21A1/COL6A1/COL6A2/COL12A1/ELN/COL18A1/COL14A1/COL8A2/MME/COL4A1/SLC36A4	3.36193916411511
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/845	112/9376	1.98140321217244	HSPA1A/HSPA1B/NFKBIA/HSPA8/TGFB3/LAMA2/BCL2/IFNGR1/SOCS1/GNAI3/LAMB1/NFKB1/CASP3/CYCS/HLA-DOB/ITGA6/TNFRSF1A/PPIF/BIRC2/CD40	3.28829850447018
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/845	97/9376	2.05902519368023	GUCY1A2/PRKG1/GUCY1B1/ADCY3/GUCY1A1/ADCY6/CACNA1H/CALM2/GNB4/CAMK2D/RASD1/GNAI3/PRKCA/GNAS/RYR2/GNG11/ADCY4/FOS	3.29955668187119
NA	NA	hsa04517	IgSF CAM signaling	42/845	299/9376	1.55861550335438	NRP1/MYLK/JAM3/SLIT3/PMP22/TRPC6/DYNLL1/UNC5C/KIRREL1/MYH11/ACTG1/NECTIN3/PARD6G/MAP2/LRRC4B/SLITRK4/EPB41L2/NCK2/PPFIA2/MPDZ/MYL12B/TUBA1A/CADM4/VCL/MSN/ABL1/PRKCA/MYL12A/ROBO1/NRP2/PIK3CA/RAP1B/CASK/MPZ/CDC42/PIK3R1/PIK3R3/NFASC/CNTNAP1/NTN1/ESAM/ACTR3	3.0895230003217
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	25/845	154/9376	1.80127564742949	GUCY1A2/MYLK/GUCY1B1/ADCY3/GUCY1A1/CACNA2D1/NFATC1/ADCY6/CALM2/PPP1CB/CAMK2D/ACTG1/JUN/GNAI3/KRAS/MEF2C/RGS2/PRKCA/PPP3CC/GNAS/RYR2/CACNB2/ADCY4/CAMK1/FOS	3.15532259153652
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/845	76/9376	2.18997197134849	PDGFA/PTEN/GADD45A/CALM2/CAMK2D/PDGFRB/KRAS/PRKCA/PIK3CA/POLK/SOS1/GADD45B/PIK3R1/PIK3R3/CAMK1	3.27805378996868
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/845	232/9376	1.62611711895531	TMSB4X/C7/ENAH/MYLK/ITGA7/PDGFA/PPP1CB/MYH11/ACTG1/PDGFRB/FGF2/ITGA11/KRAS/MYL12B/FGF7/VCL/MSN/PIP4K2A/MYL12A/ITGB5/ARHGEF12/PIK3CA/RRAS/CXCL12/ABI2/ARHGEF6/ITGA6/SOS1/CDC42/PIK3R1/CFL2/PIK3R3/ACTR3/ITGAE	3.03910345055542
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/845	77/9376	2.16153077691539	NFKBIA/MYC/CDKN1B/TGFB3/GADD45A/NFKB1/KRAS/ABL1/TGFBR2/PIK3CA/POLK/SOS1/GADD45B/PIK3R1/PIK3R3	3.22086099565219
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/845	70/9376	2.21917159763314	SGCB/LAMA2/ACTG1/HLA-B/HLA-F/SSPN/CASP3/SGCE/CYCS/ABL1/SNTB2/SGCA/HLA-DOB/CD40	3.22215445183597
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/845	86/9376	2.06434567221687	ITGA7/CACNA2D1/SGCB/LAMA2/ACTG1/ITGA11/SSPN/SGCE/SNTB2/ITGB5/SGCA/RYR2/CACNB2/ITGA6/ATP2A2/DES	3.12059989047284
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/845	94/9376	2.00669772126401	S100A9/NFKBIA/CXCL1/FOSL1/HSP90AB1/CXCL2/HSP90AA1/JUN/JUND/NFKB1/CASP3/CEBPB/CXCL8/SRSF1/TBK1/CXCL3/FOS	3.08713948164761
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/845	30/9376	2.95889546351085	SDHD/ACO1/PDHB/SUCLA2/MDH1/FH/IDH3A/SDHC	3.3819954672356
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/845	43/9376	2.58043209027109	ADH1B/ALDH3A2/ADH5/CYP2U1/ACADVL/ACADM/HADHB/ACAT1/GCDH/HADH	3.26898897522437
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/845	110/9376	1.91655728886498	ID3/MYC/ID4/TGFB3/SKP1/BMP5/BMP2/TGIF2/PITX2/BAMBI/NBL1/FMOD/THBS1/ZFYVE16/SMAD7/SIN3A/TGFBR2/NEO1/CHRD	3.04315330803952
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/845	50/9376	2.44108875739645	HBB/HGF/VCAM1/TGFB3/THBS2/SDC2/HBA2/THBS1/CXCL8/THBS3/CD40	3.21545212962672
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/845	238/9376	1.58512256973795	HGF/PDGFA/NGF/CALM2/CSF1/KITLG/GNB4/ANGPT1/PDGFRB/FGF2/PLA2G2A/NFKB1/KRAS/RASA3/FGF7/SYNGAP1/ABL1/EPHA2/PRKCA/EXOC2/PIK3CA/RRAS/RAP1B/NTRK2/RASSF1/NGFR/ETS1/TBK1/SOS1/NTF3/GNG11/CDC42/PIK3R1/PIK3R3	2.87755593058769
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/845	73/9376	2.12797276485369	HGF/RARB/GADD45A/KRAS/JAK3/PRKCA/PIK3CA/RASSF1/POLK/SOS1/GADD45B/PIK3R1/PIK3R3/KIF5C	3.04482652922913
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	26/845	170/9376	1.69701357466063	HGF/WNT6/MYC/PTEN/TGFB3/GSTM3/FZD10/GADD45A/ACTG1/KRAS/WNT3A/TGFBR2/PRKCA/SMARCD3/PIK3CA/POLK/FZD3/SOS1/SMARCE1/GADD45B/GSTM4/PIK3R1/PIK3R3/GSTT2B/FZD7/WNT2	2.88631836949873
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/845	214/9376	1.60734391417353	NFKBIA/NFATC1/B2M/SKP1/CALM2/GNB4/TRIM5/FAS/CALR/HLA-B/CGAS/BCL2/JUN/GNAI3/NFKB1/HLA-F/KRAS/CASP3/CYCS/PRKCA/PPP3CC/PIK3CA/TBK1/TNFRSF1A/GNG11/APOBEC3G/PIK3R1/CFL2/PIK3R3/AP1S2/FOS	2.82852778151777
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	48/845	368/9376	1.44728582454335	CAT/HSPA5/SRSF7/SDHD/HNRNPA2B1/ACTG1/ERN1/DDIT3/BCL2/PSMA2/HNRNPA3/TUBA1A/CASP3/NDUFB3/CYCS/NDUFA4L2/MAP1LC3B/NXT1/PSMA3/PPP3CC/COX4I2/NDUFA5/ATP5MC3/NDUFV2/SOD1/PSMD11/ACTR10/TBK1/C9orf72/NDUFB8/TNFRSF1A/TANK/NDUFB6/EIF2S1/PSMD12/UBQLN2/PSMA1/NDUFC2/NDUFA4/NDUFB5/NUP98/UQCRFS1/HAP1/PSMA5/KIF5C/NDUFA7/SDHC/VDAC1	2.75491927066333
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/845	105/9376	1.90214708368555	NFKBIA/NFATC1/EGR3/CALM2/JUN/NFKB1/KRAS/BCL10/CYLD/PPP3CC/ARHGEF12/PRKCD/PIK3CA/RRAS/MAPKAPK2/STAT2/PIK3R1/PIK3R3	2.925652429579
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/845	155/9376	1.71806833365146	ADCY3/WNT6/CDKN1B/ADCY6/FZD10/CACNA1H/CAMK2D/RASD1/PBX1/CDKN2C/GNAI3/WNT3A/PDE8A/AGTR1/NR4A1/GNAS/RAP1B/FZD3/FH/PDE8B/AHR/ADCY4/FZD7/WNT2	2.83698235607354
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/845	122/9376	1.81899311281405	SSTR2/ADCY3/SOCS2/IGFBP3/ADCY6/GHR/JUNB/SOCS3/IRS1/SOCS1/GNAI3/KRAS/PRKCA/GNAS/PIK3CA/SOS1/PIK3R1/PIK3R3/ADCY4/FOS	2.86555955671289
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/845	90/9376	1.9725969756739	NFKBIE/NFKBIA/NFATC1/PTEN/JUN/IFNGR1/NFKB1/KRAS/BATF3/HIF1A/PPP3CC/PIK3CA/TICAM1/PIK3R1/PIK3R3/FOS	2.9177887907637
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/845	75/9376	2.07122682445759	GSTM3/PMAIP1/FAS/BBC3/BCL2/CASP3/CYCS/PIK3CA/GSTM4/PIK3R1/PIK3R3/GSTT2B/TOP2B/BIRC2	2.93130676614614
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/845	157/9376	1.69618211284061	GAS6/NFATC1/DUSP8/CAMK2D/PROS1/CALR/PBX1/CASP7/CH25H/ODC1/ARG2/SIRT1/XKR6/THBS1/CASP3/CEBPB/ATP11B/MERTK/HIF1A/ITGB5/MAPKAPK2/ATP2A2/UQCRFS1/CD47	2.76850174178552
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	32/845	227/9376	1.5641738133097	ADCY3/NFKBIA/MYC/NFATC1/ADCY6/B2M/CALM2/GNB4/FAS/CALR/HLA-B/CGAS/GNAI3/NFKB1/HLA-F/KRAS/CASP3/CYCS/CXCL8/PRKCA/PPP3CC/ARHGEF12/GNAS/PIK3CA/CXCL12/TBK1/TNFRSF1A/SOS1/GNG11/PIK3R1/PIK3R3/ADCY4	2.70802743938206
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/845	116/9376	1.817425015303	CAT/SDHD/ACO1/ADH5/HIBCH/PDHB/ESD/ACSS2/RPE/SUCLA2/PFKM/ME3/MDH1/FH/HK2/IDH3A/GLUD1/ACAT1/SDHC	2.78795299377021
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/845	150/9376	1.70136489151874	HGF/RARB/WNT6/MYC/CDKN1B/TGFB3/FZD10/GADD45A/FGF2/BCL2/KRAS/WNT3A/FGF7/TGFBR2/PIK3CA/POLK/FZD3/SOS1/GADD45B/PIK3R1/PIK3R3/FZD7/WNT2	2.72519101591082
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/845	47/9376	2.36082084854589	SOCS2/SLC2A4/SOCS3/IRS1/SOCS1/PRKCD/PIK3CA/HK2/PIK3R1/PIK3R3	2.94338016170771
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/845	101/9376	1.86761966137442	ADCY3/WNT6/ADCY6/FZD10/CALM2/KITLG/CAMK2D/GNAI3/KRAS/WNT3A/EDNRB/PRKCA/GNAS/FZD3/ADCY4/FZD7/WNT2	2.75897099368535
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/845	212/9376	1.57016858323099	ENAH/ADCY3/HGF/PDGFA/NGF/ADCY6/CALM2/CSF1/KITLG/ACTG1/ANGPT1/PDGFRB/FGF2/PARD6G/GNAI3/KRAS/THBS1/FGF7/CNR1/EPHA2/PRKCA/GNAS/PIK3CA/RRAS/RAP1B/NGFR/CDC42/PIK3R1/PIK3R3/ADCY4	2.64266854561848
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/845	70/9376	2.06065934065934	HGF/TGFB3/JUN/KRAS/HIF1A/PIK3CA/RAP1B/ETS1/SOS1/FH/CDC42/PIK3R1/PIK3R3	2.80322164904575
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/845	71/9376	2.03163596966414	LDHB/MYC/PTEN/PDGFRB/KRAS/PDHB/HIF1A/PIK3CA/PFKM/HK2/GLS/PIK3R1/PIK3R3	2.74606923999376
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/845	103/9376	1.83135520193026	NFKBIA/TGFB3/FAS/CALR/JUN/IFNGR1/GNAI3/NFKB1/CXCL8/TGFBR2/GNAS/PIK3CA/TICAM1/TNFRSF1A/PIK3R1/PIK3R3/FOS	2.66998685198912
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/845	80/9376	1.94177514792899	HGF/PDGFA/GAS6/PTEN/PDGFRB/FGF2/BCL2/KRAS/EIF4E/PRKCA/PIK3CA/SOS1/PIK3R1/PIK3R3	2.66230730330351
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	34/845	254/9376	1.48527232912454	AVPR1A/MYLK/ADCY3/HGF/PDGFA/NFATC1/PDE1A/NGF/CACNA1H/CALM2/CAMK2D/PDGFRB/FGF2/EDNRA/PLN/HRC/CYSLTR2/AGTR1/FGF7/VDAC3/EDNRB/PRKCA/PPP3CC/GNAS/NTRK2/RYR2/P2RX5/ATP2A2/ADCY4/HRH2/CAMK1/PPIF/VDAC2/VDAC1	2.46758075251015
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/845	73/9376	1.97597471022129	HGF/PDGFA/PTEN/GADD45A/PDGFRB/FGF2/KRAS/FGF7/PIK3CA/POLK/GADD45B/PIK3R1/PIK3R3	2.63452610039209
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/845	122/9376	1.72804345717334	ATP1B2/MYC/RCAN2/ACTG1/NOTCH1/NOTCH3/PLN/KRAS/SIN3A/ESR1/HIF1A/PRKCA/PIK3CA/MED30/PFKM/ATP2A2/PIK3R1/PIK3R3/MED17	2.54733752184685
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/845	89/9376	1.87008842497174	COL1A2/ITGA7/THBS2/COL1A1/LAMA2/COL6A1/COL6A2/ITGA11/LAMB1/THBS1/THBS3/ITGB5/COL4A1/ITGA6/CD47	2.59558163945761
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/845	89/9376	1.87008842497174	GUCY1A2/PRKG1/GUCY1B1/ADCY3/GUCY1A1/PDGFA/ADCY6/PDGFRB/GNAI3/KRAS/TUBA1A/PRKCA/GNAS/SOS1/ADCY4	2.59558163945761
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/845	106/9376	1.77952439432846	PDGFA/NFKBIA/CDKN1B/PTEN/AR/HSP90AB1/HSP90AA1/PDGFRB/PLAU/BCL2/NFKB1/PLAT/KRAS/PIK3CA/SOS1/PIK3R1/PIK3R3	2.54013499507764
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/845	140/9376	1.66437869822485	MYLK/ADCY3/JAG1/ADCY6/CALM2/GNB4/NOTCH3/KLF2/GNAI3/PLAT/KRAS/ACTA2/MEF2C/AGTR1/MAP1LC3B/RRAS/RYR2/MEF2D/EGR1/GNG11/ADCY4	2.49259532855161
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/845	82/9376	1.89441477846731	HSPA1A/HSPA1B/HSPA8/HSPA5/HSP90AB1/B2M/HSP90AA1/CALR/HLA-B/HLA-F/HSPA4/HLA-DOB/NFYB/RFX5	2.56010973054365
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/845	59/9376	2.06871928592919	PRKG1/ADCY3/ADCY6/IRS1/GNAI3/GNAS/PIK3CA/NPY1R/PIK3R1/PIK3R3/ADCY4	2.59158600752688
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/845	133/9376	1.66855007340837	SOD2/CDKN1B/CAT/PTEN/TGFB3/CCND2/GADD45A/SLC2A4/IRS1/KLF2/KRAS/SIRT1/BCL6/TGFBR2/PIK3CA/SOS1/GABARAPL2/GADD45B/PIK3R1/PIK3R3	2.4438092622704
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/845	91/9376	1.82898758046687	PDE3A/ADCY3/PDE1A/ADCY6/GNB4/GNAI3/PDE8A/GABBR1/GRK5/PRKCA/GNAS/GNG11/PDE4B/PDE8B/ADCY4	2.50087386477387
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/845	142/9376	1.64093674472873	NFKBIA/NFATC1/FOSL1/CSF1/JUNB/SOCS3/JUN/IFNGR1/SOCS1/JUND/NFKB1/TGFBR2/CYLD/PPP3CC/PIK3CA/TNFRSF1A/ATP2A2/STAT2/PIK3R1/PIK3R3/FOS	2.42202392627742
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/845	178/9376	1.55840702080979	SERPINF1/WNT6/DAAM2/MYC/NFATC1/FOSL1/CCND2/SKP1/FZD10/FRZB/CAMK2D/BAMBI/JUN/CACYBP/SIRT1/WNT3A/PRICKLE2/PRKCA/PPP3CC/SIAH1/INVS/FZD3/SFRP4/FZD7/WNT2	2.36716314323434
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/845	76/9376	1.89797570850202	SSTR2/MYLK/ADCY3/ATP1B2/ADCY6/CALM2/CAMK2D/ACTG1/GNAI3/PRKCA/GNAS/ADCY4/HRH2	2.47368236011402
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/845	93/9376	1.78965451422027	JAG1/NFKBIE/NFKBIA/NFATC1/NOTCH1/NOTCH3/JUN/IFNGR1/NFKB1/JAK3/PPP3CC/HLA-DOB/MAML2/DLL1/FOS	2.40850994106877
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/845	69/9376	1.92971443272447	GUCY1A2/PDE3A/GUCY1B1/GUCY1A1/PDE1A/ADCY6/CALM2/EDNRA/GNAI3/AGTR1/PPP3CC/GNAS	2.43940148034504
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/845	78/9376	1.84930966469428	BTG3/TOB1/BTG2/HSPD1/PABPC5/EXOSC3/HSPA9/PNPT1/C1D/MPHOSPH6/PFKM/CNOT9/XRN1	2.37045992903243
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/845	62/9376	1.9686199656423	HEYL/JAG1/HEY2/NRARP/DTX3/NOTCH1/HES1/NOTCH3/MAML2/DLL1/DTX3L	2.40821449639726
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/845	71/9376	1.87535627968997	SOCS2/CCND2/SOCS3/SOCS1/NFKB1/KRAS/ESR1/PIK3CA/SOS1/PIK3R1/PIK3R3/FOS	2.33007477867856
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/845	193/9376	1.4947787963332	ADCY3/NFKBIA/CXCL1/ADCY6/CXCL2/GNB4/GNAI3/NFKB1/KRAS/CXCL8/CCL26/GRK5/JAK3/PRKCD/PIK3CA/RAP1B/CXCL12/SOS1/CCL8/CXCL3/GNG11/STAT2/CDC42/PIK3R1/PIK3R3/ADCY4	2.1858052451436
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	38/845	308/9376	1.36896949204642	SOD2/IFT57/SDHD/BBC3/ERN1/PSMA2/TUBA1A/CASP3/NDUFB3/CYCS/NDUFA4L2/VDAC3/POLR2K/SIN3A/PSMA3/COX4I2/NDUFA5/ATP5MC3/NDUFV2/SOD1/PSMD11/ACTR10/NDUFB8/NDUFB6/PSMD12/PSMA1/NDUFC2/NDUFA4/NDUFB5/UQCRFS1/HAP1/PPIF/PSMA5/KIF5C/NDUFA7/VDAC2/SDHC/VDAC1	2.07216380051675
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/845	73/9376	1.82397665558888	MX1/FEZ1/TRIM5/RAN/PSIP1/MDFIC/MX2/ELL2/APOBEC3G/XPO1/BICD1/CPSF6	2.22422567155506
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/845	235/9376	1.41649250912753	PRKG1/ADCY3/ADCY6/SDHD/ACTG1/ZNF516/KRAS/NDUFB3/NDUFA4L2/NDUFAF4/CNR1/SMARCD3/COX4I2/GNAS/COX11/NDUFA5/ATP5MC3/NDUFV2/NDUFB8/SOS1/NDUFB6/SMARCE1/NDUFC2/COA6/NDUFA4/NDUFB5/ADCY4/UQCRFS1/NDUFA7/SDHC	2.03497132129129
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	29/845	226/9376	1.42380478609206	SSTR2/PDE3A/ADCY3/ATP1B2/NFKBIA/NFATC1/ADCY6/CALM2/PPP1CB/CAMK2D/HTR1F/EDNRA/PLN/JUN/GNAI3/NFKB1/GABBR1/GNAS/PIK3CA/RRAS/RAP1B/RYR2/NPY1R/PDE4B/ATP2A2/PIK3R1/PIK3R3/ADCY4/FOS	2.02966120738794
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/845	144/9376	1.54109138724523	ID3/WNT6/MYC/ID4/TBX3/FZD10/PCGF5/LIF/FGF2/KRAS/WNT3A/JAK3/PIK3CA/MEIS1/FZD3/PIK3R1/PIK3R3/FZD7/SMARCAD1/WNT2	2.05929227814651
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	13/845	83/9376	1.73790546802595	SKP1/PCGF5/SCML1/USP45/CBX7/AEBP2/PHC2/PHF19/UBE2D1/CBX6/MAX/MBD5/EZH2	2.12508266133431
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/845	109/9376	1.62874979642799	NFKBIE/NFKBIA/NFATC1/HSP90AB1/HSP90AA1/JUN/IFNGR1/NFKB1/TGFBR2/JAK3/HIF1A/PPP3CC/HLA-DOB/RARA/AHR/FOS	2.07795216903618
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/845	59/9376	1.88065389629927	MYC/PTEN/GADD45A/KRAS/PIK3CA/POLK/SOS1/GADD45B/PIK3R1/PIK3R3	2.13553768999208
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/845	110/9376	1.61394298009683	LDHB/CDKN1B/CAMK2D/ANGPT1/BCL2/IFNGR1/NFKB1/PDHB/EIF4E/HIF1A/PRKCA/PIK3CA/PFKM/HK2/PIK3R1/PIK3R3	2.03841334690921
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	18/845	128/9376	1.5603550295858	GUCY1A2/PDE3A/PDE5A/GUCY1B1/ADCY3/GUCY1A1/PDE1A/ADCY6/PDE8A/GMPR/PDE6D/HPRT1/HDDC2/PDE4B/PDE8B/ADCY4/ADK/NME1	2.00890023871814
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/845	93/9376	1.67034421327225	GUCY1A2/PRKG1/GUCY1B1/ADCY3/GUCY1A1/ATP1B2/ADCY6/CALM2/PRKCA/GNAS/BST1/PRH1/SLC12A2/ADCY4	2.04460390275661
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/845	138/9376	1.52769059257354	SDHD/NDUFB3/CYCS/NDUFA4L2/ATP6V1G1/PPA1/COX4I2/COX11/NDUFA5/ATP5MC3/NDUFV2/NDUFB8/NDUFB6/NDUFC2/NDUFA4/NDUFB5/UQCRFS1/NDUFA7/SDHC	1.96536825870547
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/845	77/9376	1.72922462153231	TGFB3/GADD45A/NFKB1/KRAS/TGFBR2/PIK3CA/POLK/ARHGEF6/GADD45B/CDC42/PIK3R1/PIK3R3	2.02209979041627
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/845	78/9376	1.70705507510241	CALM2/CASP7/C1S/JUN/GNAI3/NFKB1/CASP3/C1R/CXCL8/TICAM1/CFL2/FOS	1.97342122999695
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	31/845	253/9376	1.35957153214678	NFKBIA/SKP1/PPID/RIPK2/ACTG1/CALCOCO2/CGAS/UBE2N/BCL2/JUN/NFKB1/MYL12B/CYCS/TIFA/UBB/CXCL8/VCL/MAP1LC3B/BCL10/MYL12A/PRKCD/PIK3CA/UBE2D1/TBK1/TNFRSF1A/HK2/CDC42/PIK3R1/PIK3R3/VDAC1/ACTR3	1.82469694732375
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/845	38/9376	2.04397383992526	ATP1B2/IRS1/KRAS/PRKCA/PIK3CA/PIK3R1/PIK3R3	2.02940395019461
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/845	71/9376	1.71907658971581	JAM3/NFKBIA/CXCL1/CXCL2/JUN/NFKB1/CASP3/CXCL8/ATP6V1G1/CXCL3/CDC42	1.91408031736337
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/845	142/9376	1.48465705475456	SKP1/UBE2B/UBE2N/SOCS3/SOCS1/UBB/UBA2/UBE2L6/PIAS2/SIAH1/KLHL13/ANAPC10/UBE2D1/UBE2W/RHOBTB1/UBE2E3/NEDD4/RCHY1/BIRC2	1.8314615167703
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/845	63/9376	1.76124729970884	WNT6/FZD10/BMP2/GADD45A/WNT3A/POLK/FZD3/GADD45B/FZD7/WNT2	1.90794240294298
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/845	116/9376	1.53046317078147	JAM3/VCAM1/ACTG1/GNAI3/MYL12B/VCL/MSN/PRKCA/MYL12A/PIK3CA/RAP1B/CXCL12/CDC42/PIK3R1/PIK3R3/ESAM	1.80922574839094
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/845	144/9376	1.46403681788297	ADH1B/NFKBIA/CXCL1/CXCL2/FAS/ALDH3A2/NFKB1/ADH5/TRA2A/SIRT1/CASP3/CXCL8/ACADVL/ACADM/TBK1/TICAM1/TNFRSF1A/CXCL3/LPIN3	1.76603704728531
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/845	90/9376	1.60273504273504	SOD2/ADCY3/CAT/ADCY6/IRS1/NFKB1/KRAS/SIRT1/EIF4E/PIK3CA/PIK3R1/PIK3R3/ADCY4	1.80820380432938
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/845	99/9376	1.56911123064969	ADCY3/NGF/ADCY6/CALM2/PPP1CB/CAMK2D/TRPV2/PRKCA/GNAS/PRKCD/PIK3CA/PIK3R1/PIK3R3/ADCY4	1.79153376043116
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/845	99/9376	1.56911123064969	PDGFA/CHPT1/WASF3/PDGFRB/JUN/KRAS/DGKG/HIF1A/PRKCA/PIK3CA/SOS1/PIK3R1/PIK3R3/FOS	1.79153376043116
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/845	17/9376	2.61079011486251	CYP7B1/SCP2/CH25H/HSD17B4	2.09200498226934
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/845	154/9376	1.44102051794359	ADCY3/CACNA2D1/ATP1B2/ADCY6/TPM4/CALM2/PPP1CB/CAMK2D/PLN/BCL2/GNAI3/AGTR1/TPM2/PRKCA/GNAS/RYR2/CACNB2/SCN4B/ATP2A2/ADCY4	1.7366832600775
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/845	91/9376	1.58512256973795	NFKBIE/NFKBIA/NFATC1/JUN/NFKB1/KRAS/BCL10/PPP3CC/PIK3CA/SOS1/PIK3R1/PIK3R3/FOS	1.76518656832333
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/845	109/9376	1.52695293415124	NFKBIA/JUN/NFKB1/IRF7/CXCL8/PIK3CA/TBK1/MAP3K8/TICAM1/STAT2/PIK3R1/PIK3R3/TLR3/FOS/CD40	1.74152420998033
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/845	65/9376	1.70705507510241	ADCY3/ADCY6/CACNA1H/PBX1/PDE8A/AGTR1/NR4A1/GNAS/PDE8B/ADCY4	1.80022082196664
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/845	93/9376	1.55103391232423	ADCY3/ADCY6/CALM2/CAMK2D/JUN/KRAS/PRKCA/GNAS/PRKCD/SOS1/EGR1/CDC42/ADCY4	1.68069786444446
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/845	149/9376	1.41490806560502	AVPR1A/ADCY3/PDGFA/ADCY6/KITLG/PDGFRB/KRAS/AGTR1/AGPAT5/CXCL8/DGKG/PRKCA/GNAS/PIK3CA/RRAS/SOS1/PIK3R1/PIK3R3/ADCY4	1.60667772615851
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/845	50/9376	1.77533727810651	CKB/ALDH3A2/GATM/ODC1/ARG2/SAT2/OAT/LAP3	1.72998359002582
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/845	168/9376	1.38698224852071	HSP90AB1/PPID/SPATA2L/HSP90AA1/CAMK2D/FAS/BCL2/IFNGR1/VDAC3/JAK3/CYLD/TNFRSF10B/TICAM1/TNFRSF1A/CHMP5/GLUD1/STAT2/TLR3/VDAC2/BIRC2/VDAC1	1.5928579629137
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	21/845	168/9376	1.38698224852071	PDGFA/SOCS2/MYC/CCND2/GHR/LIF/PDGFRB/IL15RA/SOCS3/BCL2/IFNGR1/SOCS1/JAK3/FHL1/PIAS2/PIK3CA/MCL1/SOS1/STAT2/PIK3R1/PIK3R3	1.5928579629137
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/845	122/9376	1.45519449025124	NFKBIE/NFKBIA/NFATC1/JUN/NFKB1/KRAS/NCK2/BCL10/PPP3CC/PIK3CA/MAP3K8/SOS1/CDC42/PIK3R1/PIK3R3/FOS	1.59267141724872
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/845	169/9376	1.37877525296733	PTEN/CALCOCO2/ERN1/IRS1/BCL2/KRAS/VMP1/UBB/MAP1LC3B/HIF1A/PRKCD/PIK3CA/RRAS/TBK1/RAB33B/C9orf72/TANK/EIF2S1/GABARAPL2/PIK3R1/PIK3R3	1.56379528495133
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/845	86/9376	1.54825925416265	MYC/CDKN1B/CAMK2D/JUN/KRAS/NCK2/ABL1/PRKCA/PIK3CA/SOS1/PIK3R1/PIK3R3	1.60746439164558
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/845	51/9376	1.74052674324168	ADCY3/ACTG1/SEC61B/SEC61G/ATP6V1G1/PRKCA/GNAS/SLC12A2	1.66884282808637
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/845	115/9376	1.44728582454335	ADCY3/ACHE/ADCY6/GNB4/CAMK2D/BCL2/GNAI3/KRAS/PRKCA/PIK3CA/GNG11/PIK3R1/PIK3R3/ADCY4/FOS	1.51886485969952
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/845	125/9376	1.42026982248521	S1PR3/PTEN/BCL2/GNAI3/NFKB1/KRAS/DEGS1/ORMDL1/CERS6/SPTSSA/PRKCA/CERS2/PIK3CA/TNFRSF1A/PIK3R1/PIK3R3	1.4886852805803
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/845	88/9376	1.51307154384077	C7/F3/PROS1/PLAU/C1S/CFH/PLAT/CFHR1/C1R/CFI/F5/CFD	1.52185117074032
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/845	144/9376	1.38698224852071	ERN1/PSMA2/CYCS/GTF2B/VDAC3/PSMA3/PRKCA/PIK3CA/PSMD11/PSMD12/PSMA1/ATP2A2/PIK3R1/PIK3R3/PPIF/PSMA5/VDAC2/VDAC1	1.4727818164241
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/845	44/9376	1.7652501344809	ADCY3/ADCY6/DYNLL1/GNAS/DYNC2LI1/DYNC1I1/DYNC2H1	1.60123992237458
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/845	28/9376	1.98140321217244	MOCS1/PCBD1/MOCS2/CBR1/DHFR	1.63674551904655
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/845	89/9376	1.4960707399774	ADCY3/ADCY6/GNB4/GNAI3/GABBR1/PRKCA/PLCL1/GABARAPL2/GNG11/GLS/ADCY4/HAP1	1.47984051689838
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/845	155/9376	1.36013743080741	THBS2/ACTG1/COLEC11/CALR/SEC61B/HLA-B/SEC22B/HLA-F/THBS1/TUBA1A/C1R/SEC61G/ATP6V1G1/THBS3/STX12/ITGB5/HLA-DOB/DYNC1I1/DYNC2H1	1.42285001173466
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/845	109/9376	1.42515607187449	NFKBIA/PTEN/SLC2A4/PPP1CB/SOCS3/IRS1/NFKB1/PRKCD/PPP1R3C/PIK3CA/TNFRSF1A/GFPT2/PIK3R1/PIK3R3	1.40509625092448
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/845	29/9376	1.91307896347684	TEAD2/YAP1/SAV1/RASSF1/FAT4	1.54983418663599
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/845	46/9376	1.68850012863391	PSMB9/PSMA2/PSMA3/PSMD11/PSMD12/PSMA1/PSMA5	1.4731811098628
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/845	158/9376	1.33431203655157	RNF152/WNT6/PTEN/FZD10/IRS1/KRAS/WNT3A/ATP6V1G1/EIF4E/PRKCA/PIK3CA/FZD3/TNFRSF1A/SOS1/LPIN3/PIK3R1/PIK3R3/FZD7/WNT2	1.33375550962357
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/845	149/9376	1.34043922004686	ADCY3/ADCY6/GNB4/GNAI3/NDUFB3/NDUFA4L2/CNR1/PRKCA/NDUFA5/NDUFV2/NDUFB8/NDUFB6/GNG11/NDUFC2/NDUFA4/NDUFB5/ADCY4/NDUFA7	1.31830677035036
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/845	102/9376	1.41417797888386	ADCY3/ATP1B2/ADCY6/TRPC1/PLA2G2A/PRKCA/GNAS/RAP1B/BST1/RYR2/SLC12A2/ATP2A2/ADCY4	1.32363293937739
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/845	65/9376	1.53634956759217	TRPC4/CACNA1H/TRPC1/KRAS/GABBR1/PRKCA/PIK3CA/PIK3R1/PIK3R3	1.36559045176555
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/845	160/9376	1.31763313609467	JAM3/VCAM1/SDC2/NECTIN3/HLA-B/HLA-F/LRRC4B/SLITRK4/NEGR1/NEO1/HLA-DOB/MPZ/NRXN3/NRXN2/ITGA6/NFASC/CNTNAP1/ESAM/CD40	1.27534763906098
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/845	170/9376	1.30539505743126	JAM3/MYH11/ACTG1/DLG3/YBX3/PARD6G/JUN/MPDZ/MYL12B/TUBA1A/MSN/HSPA4/MYL12A/RAB13/LLGL1/DLG2/NEDD4/CDC42/RAP2C/ACTR3	1.26463442931815
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/845	48/9376	1.6181459566075	ALDH3A2/HIBCH/OXCT1/ACADM/HADHB/ACAT1/HADH	1.35123661345121
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/845	57/9376	1.55731340184781	SCP2/ELOVL4/HSD17B4/ACADVL/ACADM/HADHB/ACAT1/HADH	1.32820857709656
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/845	31/9376	1.78965451422027	CAT/ACO1/ACSS2/MDH1/ACAT1	1.38593332700199
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/845	31/9376	1.78965451422027	HSPA5/SRP9/SEC61B/SEC61G/SPCS3	1.38593332700199
Genetic Information Processing	Translation	hsa03010	Ribosome	25/845	222/9376	1.24953355722587	RPS7/RPL22L1/MRPL50/MRPL32/MRPL18/MRPL42/RPL32/MRPS30/RPL36A/RPS21/MRPS22/MRPL16/RPS10/MRPL13/RPS15A/RPL7A/MRPL36/RPL26/MRPL44/MRPL47/RPS18/RPL30/MRPS9/RPS23/MRPL35	1.18416988608455
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/845	95/9376	1.40158206166303	CXCL1/TGFB3/CXCL2/CSF1/ANGPT1/JUN/CXCL8/ATP6V1G1/CXCL12/HLA-DOB/CXCL3/FOS	1.23809150285682
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/845	67/9376	1.49048838647002	ADH1B/LDHB/ALDH3A2/ADH5/PDHB/ACSS2/PFKM/MINPP1/HK2	1.26802739618059
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/845	23/9376	1.92971443272447	ACE2/ENPEP/AGTR1/MME	1.4049214571185
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/845	23/9376	1.92971443272447	ATP1B2/MDH1/GLS/GLUD1	1.4049214571185
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/845	115/9376	1.35080010290713	ADCY3/ADCY6/STK39/BCL2/JUND/GNAI3/MEF2C/PRKCA/GNAS/MEF2D/EGR1/PDE4B/ADCY4/FOS	1.19122476020469
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/845	68/9376	1.46856943961016	RUNX1T1/MYC/NFKB1/KRAS/PIK3CA/RARA/SOS1/PIK3R1/PIK3R3	1.22043386749432
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/845	32/9376	1.73372781065089	LDHB/HIBCH/ACSS3/ACSS2/SUCLA2	1.3084513406728
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/845	205/9376	1.24490114013566	NFKBIA/CDKN1B/CCND2/EGR3/PMAIP1/HLA-B/JUN/NFKB1/HLA-F/KRAS/IRF7/GTF2H2/TRAF1/CASP3/GTF2B/VDAC3/JAK3/PIK3CA/YWHAQ/MAPKAPK2/CDC42/PIK3R1/PIK3R3	1.1157667429433
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/845	69/9376	1.44728582454335	CALM2/PPP1CB/CAMK2D/JUN/SIRT1/PRKCA/PPP3CC/GNAS/FOS	1.17359660571362
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/845	60/9376	1.47944773175542	KRAS/PRKCA/PPP3CC/PIK3CA/MAPKAPK2/CDC42/PIK3R1/PIK3R3	1.1725089738688
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/845	60/9376	1.47944773175542	GUCY1A2/PRKG1/GUCY1B1/GUCY1A1/GNAI3/KRAS/PRKCA/GNAS	1.1725089738688
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/845	98/9376	1.35867648834682	PTEN/CALM2/INPP4B/INPP1/DGKG/PIP4K2A/PRKCA/PIK3CA/INPP5E/PIK3R1/PIK3R3/MTMR2	1.12331817201905
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/845	98/9376	1.35867648834682	ADCY3/ATP1B2/ADCY6/CACNA1H/CALM2/CAMK2D/AGTR1/NR4A1/PRKCA/GNAS/ADCY4/CAMK1	1.12331817201905
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/845	42/9376	1.58512256973795	CAT/INMT/ALDH3A2/ACAT1/GCDH/HADH	1.19605628894138
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/845	42/9376	1.58512256973795	SLC39A14/VDAC3/MAP1LC3B/SAT2/PRNP/VDAC2	1.19605628894138
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/845	138/9376	1.28647628848298	SOCS2/RHOQ/CALM2/SLC2A4/PPP1CB/SOCS3/IRS1/SOCS1/KRAS/EIF4E/PPP1R3C/PIK3CA/SOS1/HK2/PIK3R1/PIK3R3	1.06697260133122
NA	NA	hsa04519	Cadherin signaling	42/845	404/9376	1.15352979084891	VIM/ENAH/CDH6/MYO1B/WNT6/NFKBIA/DAAM2/PCDH18/FZD10/PPP1CB/ACTG1/PDGFRB/TEAD2/NFKB1/PCDHGB7/PCDH10/KRAS/PCDHGA12/WNT3A/MPDZ/YAP1/SAV1/VCL/PCDHGA9/PCDHGA10/PRICKLE2/PCDHB15/RRAS/PCDHB4/ABI2/FZD3/YWHAQ/KRT17/SCN4B/PCDHGB6/CDC42/DES/KRT6A/FAT4/FZD7/ACTR3/WNT2	0.992779338361191
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/845	100/9376	1.33150295857988	CXCL1/CXCL2/CSF1/CXCL8/CCL26/CXCL12/TNFRSF10B/TNFRSF1A/CCL8/CXCL3/IL18R1/TNFRSF10D	1.04886854280127
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	34/845	323/9376	1.16798505138586	VIM/SPRY2/PDGFA/MYC/CDKN1B/PTEN/CCND2/NOTCH1/PDGFRB/ZEB2/NOTCH3/HOXD10/PLAU/IRS1/BCL2/SOCS1/NFKB1/KRAS/SIRT1/WNT3A/THBS1/CASP3/ABL1/PRKCA/PIK3CA/MCL1/RASSF1/CCNG1/FZD3/SOS1/GLS/PIK3R1/PIK3R3/EZH2	0.966918031524518
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/845	72/9376	1.38698224852071	NFKBIA/ISG15/NFKB1/IRF7/CXCL8/SIKE1/CYLD/TBK1/TANK	1.03737663662211
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/845	44/9376	1.51307154384077	CCNH/GTF2H2/TAF9B/GTF2B/TAF7/MNAT1	1.07357137491977
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/845	44/9376	1.51307154384077	HSPD1/FAS/HLA-B/HLA-F/CPE/HLA-DOB	1.07357137491977
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/845	18/9376	1.84930966469428	THAP11/ZNF143/MMADHC	1.13507568351087
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/845	10/9376	2.21917159763314	SELENBP1/SQOR	1.21395274524839
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/845	37/9376	1.49944026867104	HBB/VCAM1/FAS/HBA2/PRKCA	0.957961932842405
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/845	37/9376	1.49944026867104	MYC/GADD45A/KRAS/POLK/GADD45B	0.957961932842405
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/845	38/9376	1.45998131423233	NNMT/SIRT1/BST1/NAMPT/NNT	0.894167900017135
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/845	87/9376	1.27538597565123	CACNA2D1/ATP1B2/TPM4/HRC/TPM2/COX4I2/RYR2/CACNB2/ATP2A2/UQCRFS1	0.812140158871237
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/845	138/9376	1.20607152045279	NFKBIA/NFATC1/ACTG1/JUN/NFKB1/CXCL8/ARHGEF12/PIK3CA/TBK1/TICAM1/CDC42/PIK3R1/PIK3R3/FOS/ACTR3	0.767507382206464
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/845	200/9376	1.1650650887574	MYO1B/NFKBIA/WASF3/MYH11/ACTG1/FAS/CASP7/JUN/NFKB1/NCK2/TUBA1A/CASP3/CYCS/CXCL8/ABL1/ARHGEF12/TNFRSF10B/TNFRSF1A/CDC42/FOS/ACTR3	0.742604449080226
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/845	39/9376	1.42254589591868	ALDH1L2/MTHFD2/MAT2A/DHFR/MTHFD2L	0.832178581285439
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/845	39/9376	1.42254589591868	FAS/HLA-B/HLA-F/HLA-DOB/CD40	0.832178581285439
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/845	181/9376	1.16475857334336	TGFB3/CALM2/RIPK2/HSPD1/CAMK2D/BCL2/IFNGR1/NFKB1/CASP3/CYCS/CEBPB/HSPA9/BCL10/PPP3CC/ARHGEF12/HLA-DOB/NFYB/TNFRSF1A/RFX5	0.704409922717978
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/845	110/9376	1.21045723507262	ADCY3/ADCY6/HSP90AB1/HSP90AA1/GNAI3/PGR/KRAS/PIK3CA/ANAPC10/PIK3R1/PIK3R3/ADCY4	0.698760065402131
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/845	194/9376	1.14390288537791	MYO1B/TPM4/DYNLL1/MYH11/ACTG1/ACTG2/DYNLT3/ACTA2/MYL12B/TUBA1A/CAPZA2/KIF18A/TPM2/MYL12A/DYNC2LI1/DYNC1I1/ACTR10/DYNC2H1/TUBE1/KIF5C	0.637405408840474
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/845	41/9376	1.35315341319094	MYC/KRAS/THBS1/CXCL8/RASSF1	0.713201416285541
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/845	61/9376	1.27329517896983	MT1M/MT1E/ATP1B2/MT2A/MT1A/CYBRD1/HEPH	0.673937279138603
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/845	133/9376	1.16798505138586	NFATC1/FAS/HLA-B/IFNGR1/KRAS/CASP3/PRKCA/PPP3CC/PIK3CA/TNFRSF10B/SOS1/PIK3R1/PIK3R3/MICB	0.614050376820429
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/845	250/9376	1.10958579881657	HSPA1A/HSPA1B/HSPA8/SNX3/HLA-B/PARD6G/SNX1/HLA-F/SPART/AGAP1/ZFYVE16/ARF4/GRK5/CAPZA2/TGFBR2/VPS29/RUFY2/RAB11FIP2/CHMP5/NEDD4/CDC42/VPS26A/KIF5C/EPS15/ACTR3	0.552710953665748
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/845	52/9376	1.28029130632681	ADCY3/ADCY6/HSD17B2/GNAS/HSD17B7/ADCY4	0.637858267201952
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/845	52/9376	1.28029130632681	LPL/VDAC3/VAPA/SORT1/VDAC2/VDAC1	0.637858267201952
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/845	93/9376	1.19310300948018	SNAI2/WASF3/ACTG1/NECTIN3/MYL12B/VCL/TGFBR2/MYL12A/RAP1B/CDC42	0.588979749507993
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/845	83/9376	1.20316532401797	NFKBIA/CGAS/IFI16/CASP7/NFKB1/IRF7/CASP3/POLR2K/TBK1	0.585092706535903
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/845	63/9376	1.23287310979619	ALDH3A2/SETMAR/AASS/ACAT1/EZH2/GCDH/HADH	0.583658531012564
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/845	63/9376	1.23287310979619	GGT5/PTGES3/PTGR1/PLA2G2A/EPHX2/CYP2U1/CBR1	0.583658531012564
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/845	115/9376	1.15782865963468	DUSP1/GNB4/TRPC1/HTR1F/GNAI3/KRAS/CASP3/KCND2/PRKCA/GNAS/GNG11/CYP4X1	0.535944561215036
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/845	23/9376	1.44728582454335	ARG2/GLS/GLUD1	0.675908031807579
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/845	105/9376	1.16242321780783	CALCOCO2/JUN/KRAS/UBB/MAP1LC3B/HIF1A/SIAH1/RRAS/TBK1/EIF2S1/GABARAPL2	0.52673659361422
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/845	54/9376	1.23287310979619	LDHB/CISD1/MAT2A/ADI1/MDH1/APIP	0.54010188761611
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/845	65/9376	1.19493855257169	ALDH3A2/LPL/GPAT2/AGPAT5/DGKG/MBOAT2/LPIN3	0.496329711363378
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/845	86/9376	1.16119444062199	ADCY3/ATP1B2/ADCY6/CAMK2D/PRKCA/GNAS/RYR2/KCNMB1/ADCY4	0.472612767525132
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/845	108/9376	1.13013368397984	DDX39B/SUMO2/RAN/SUMO1/NXT1/KPNA2/NMD3/EIF4A3/XPO1/NUP98/KPNA4	0.428077706700618
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/845	45/9376	1.23287310979619	ABCC9/ABCA8/ABCA6/ABCA9/ABCC5	0.492805477878926
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/845	66/9376	1.17683342298727	NFATC1/TGFB3/JUN/IFNGR1/NFKB1/HLA-DOB/IL18R1	0.453707023890186
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/845	98/9376	1.13223040695568	MARCKSL1/WASF3/PRKCA/PRKCD/PIK3CA/CDC42/PIK3R1/CFL2/PIK3R3/ACTR3	0.414124772190714
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/845	67/9376	1.15926874503224	CALM2/PPP1CB/CAMK2D/KRAS/PRKCA/PPP3CC/RAP1B	0.411747021187669
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/845	78/9376	1.13803671673494	PTEN/INPP4B/INPP1/PIP4K2A/PIK3CA/INPP5E/MINPP1/MTMR2	0.385266433855033
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/845	78/9376	1.13803671673494	MARCKSL1/NFKBIA/TGFB3/JUN/IFNGR1/NFKB1/HLA-DOB/FOS	0.385266433855033
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/845	16/9376	1.38698224852071	GBGT1/B3GALNT1	0.48755894919339
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/845	37/9376	1.19955221493683	NIT2/GFPT2/GLS/GLUD1	0.382755331348304
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/845	298/9376	1.04256383781423	CXCL1/TGFB3/NGF/TNFSF12/BMP5/CXCL2/BMP2/CSF1/GHR/LIF/EDA/FAS/IL15RA/IFNGR1/GDF11/TNFSF9/CXCL8/CCL26/TGFBR2/CXCL12/NGFR/TNFRSF10B/TNFRSF1A/CCL8/CXCL3/IL18R1/CD40/TNFRSF10D	0.234999990228286
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/845	48/9376	1.15581854043393	ATP1B2/PIK3CA/HK2/PIK3R1/PIK3R3	0.340611654316034
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/845	59/9376	1.12839233777956	GGT5/GSTM3/ODC1/GSTM4/GSTT2B/LAP3	0.311344419852848
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/845	27/9376	1.23287310979619	OXCT1/ACAT1/HADH	0.381357829104867
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/845	27/9376	1.23287310979619	SCP2/ELOVL4/HSD17B4	0.381357829104867
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/845	70/9376	1.10958579881657	NFKBIE/NFKBIA/SLC2A4/SOCS3/IRS1/NFKB1/TNFRSF1A	0.289624832304418
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/845	103/9376	1.07726776584133	PPP1CB/DDX39B/PABPC5/NXT1/PELO/PAPOLG/EIF4A3/ETF1/RNGTT/CPSF6	0.248153759548169
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/845	158/9376	1.05340423938282	MYC/CDKN1B/TGFB3/CCND2/SKP1/GADD45A/CCNH/CDKN2C/NDC80/ABL1/ANAPC10/PTTG1/YWHAQ/GADD45B/MAD2L1BP	0.213059030864723
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/845	17/9376	1.30539505743126	INMT/SEPHS2	0.396630185280937
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/845	17/9376	1.30539505743126	MYH11/NRP2	0.396630185280937
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/845	104/9376	1.06690942193901	CHPT1/ACHE/LPGAT1/ETNK1/PLA2G2A/GPAT2/AGPAT5/DGKG/MBOAT2/LPIN3	0.21593908544458
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/845	28/9376	1.18884192730347	ELOVL4/HADHB/HADH	0.314943108488371
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/845	83/9376	1.06948028801597	SOD2/CAT/SCP2/EPHX2/SOD1/HSD17B4/NUDT7/FAR1	0.200095217836301
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/845	138/9376	1.04526198439242	ADCY3/AR/ADCY6/SKP1/CALM2/PPP1CB/CAMK2D/PGR/PPP3CC/ANAPC10/PTTG1/YWHAQ/ADCY4	0.168576943956959
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/845	116/9376	1.05219342991226	ADCY3/ADCY6/GNB4/TRPC1/GNAI3/PRKCA/PPP3CC/GNAS/GNG11/GLS/ADCY4	0.178013672758829
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/845	85/9376	1.04431604594501	CMPK2/GMPR/HPRT1/HDDC2/NT5C3B/DUT/ADK/NME1	0.129167501326215
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/845	63/9376	1.0567483798253	CCNH/GTF2H2/POLR2K/RFC5/POLR2M/MNAT1	0.142230573702424
NA	NA	hsa04081	Hormone signaling	20/845	219/9376	1.01332036421604	SSTR2/AVPR1A/PRKG1/ADCY3/ADCY6/GHR/GNB4/ADRA2A/IRS1/GNAI3/AGTR1/HEPH/ADRA2C/ESR1/GNAS/PIK3CA/GNG11/PIK3R1/PIK3R3/ADCY4	0.0627733884131486
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/845	30/9376	1.10958579881657	PIGK/PIGA/PGAP1	0.189197780981524
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/845	30/9376	1.10958579881657	NFKB1/ABCC5/DHFR	0.189197780981524
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/845	75/9376	1.0356134122288	ADCY3/ATP1B2/HSPA5/ADCY6/PRKCA/GNAS/ADCY4	0.0974525971982479
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/845	53/9376	1.04677905548733	ATP1B2/ADCY6/ESR1/PRKCA/GNAS	0.107479481620164
NA	NA	hsa04082	Neuroactive ligand signaling	18/845	199/9376	1.00364544616574	P2RY14/ADCY3/OGFRL1/ACHE/ADCY6/GNB4/HTR1F/ADRA2A/GNAI3/GABBR1/ADRA2C/PRKCA/GNAS/P2RX5/SLC17A9/GNG11/ADCY4/HRH2	0.0163584022501314
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/845	31/9376	1.07379270853216	AOC3/ALDH3A2/HIBCH	0.129514581633785
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/845	54/9376	1.02739425816349	FAS/HLA-B/HLA-F/HLA-DOB/CD40	0.0635354187389551
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/845	20/9376	1.10958579881657	LBR/HSD17B7	0.154396762922895
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/845	78/9376	0.995782127143074	ACTG1/VCL/PIK3CA/CDC42/PIK3R1/PIK3R3/ACTR3	-0.0117722651804463
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/845	79/9376	0.98317729009063	ADH1B/GSTM3/EPHX1/ADH5/CBR1/GSTM4/GSTT2B	-0.0472554722734843
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/845	21/9376	1.0567483798253	CHSY3/CHST7	0.0819323176372852
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/845	21/9376	1.0567483798253	ALDH3A2/PANK1	0.0819323176372852
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/845	56/9376	0.990701606086221	CCND2/EFCAB7/BCL2/EVC/EVC2	-0.0219638272660486
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/845	33/9376	1.00871436256052	ACO1/PDHB/IDH3A	0.0157820509819474
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/845	33/9376	1.00871436256052	SEC22B/VAMP5/STX2	0.0157820509819474
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/845	45/9376	0.986298487836949	FAS/HLA-B/HLA-F/HLA-DOB	-0.0289951049096465
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/845	69/9376	0.964857216362233	KRAS/PRKCA/PIK3CA/SOS1/PIK3R1/PIK3R3	-0.0922082689177963
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/845	22/9376	1.00871436256052	ALDH3A2/HNMT	0.0128784116848543
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/845	34/9376	0.979046293073442	SKP1/NFIL3/BHLHE40	-0.0385207215945344
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/845	46/9376	0.964857216362233	BLVRA/HEPH/ALAS1/FXN	-0.0751948806543823
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/845	70/9376	0.951073541842773	GSTM3/EPHX1/NAT1/CBR1/GSTM4/GSTT2B	-0.129307970485804
Genetic Information Processing	Transcription	hsa03040	Spliceosome	21/845	243/9376	0.958901307619256	HSPA1A/HSPA1B/HSPA8/SRSF7/DDX5/DDX39B/TRA2A/HNRNPA3/BCAS2/SF3B6/SRSF10/PHF5A/SNRPA1/SNRNP40/SRSF1/SRSF2/EIF4A3/PRPF38A/SRSF9/RBMXL1/SF3B1	-0.204285919636212
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/845	82/9376	0.947207389233656	GSTM3/NAT1/HPRT1/DUT/GSTM4/GSTT2B/NME1	-0.151109842745808
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/845	59/9376	0.940326948149634	CMPK2/HDDC2/NT5C3B/DUT/NME1	-0.144703897681959
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/845	23/9376	0.964857216362233	LARGE1/B3GALNT2	-0.0531053935033447
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/845	49/9376	0.905784325564545	JUN/GNAI3/NFKB1/GNAS	-0.208096240698473
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/845	37/9376	0.899664161202623	ADH1B/AOC3/ADH5	-0.192451270145797
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/845	133/9376	0.917702540374605	CALM2/GNB4/PPP1CB/CAMK2D/GNAI3/PRKCA/PPP3CC/GNAS/GNG11/KIF5C/FOS	-0.300829065904558
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/845	50/9376	0.887668639053254	IL15RA/CXCL12/HLA-DOB/CD40	-0.250641129442046
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/845	12/9376	0.92465483234714	NGFR	-0.0821919616583218
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/845	38/9376	0.875988788539396	GNPDA2/HK2/GFPT2	-0.24106815016034
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/845	38/9376	0.875988788539396	JAK3/RFX5/CD40	-0.24106815016034
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/845	75/9376	0.887668639053254	ACO1/ARG2/MAT2A/RPE/PFKM/IDH3A	-0.307383712651452
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/845	41/9376	0.811892047914562	AOC3/GATM/ALAS1	-0.379888322838813
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/845	28/9376	0.792561284868977	B3GNT2/B3GALNT1	-0.345958096790717
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/845	14/9376	0.792561284868977	B3GNT2	-0.244446337623041
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/845	68/9376	0.815871910894535	ADH1B/ALDH1A1/ADH5/DHRS4L2/ALDH1A3	-0.479579197670847
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/845	107/9376	0.829596858928275	LDHB/CALM2/CAMK2D/SIRT1/PDHB/PPP3CC/GNAS/PFKM	-0.557913750635873
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/845	44/9376	0.756535771920387	CHST8/OSTC/MAN1A1	-0.509434267444632
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/845	16/9376	0.693491124260355	AOC3	-0.386170543856538
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/845	31/9376	0.715861805688108	RPE/PFKM	-0.498694791050317
NA	NA	hsa04981	Folate transport and metabolism	2/845	31/9376	0.715861805688108	ABCC5/DHFR	-0.498694791050317
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/845	32/9376	0.693491124260355	PFKM/HK2	-0.54659499553912
Human Diseases	Immune disease	hsa05310	Asthma	2/845	32/9376	0.693491124260355	HLA-DOB/CD40	-0.54659499553912
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/845	86/9376	0.774129627081326	PDE1A/ADCY6/HTR1F/GABBR1/ADCY4/TAS2R30	-0.662238856595315
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/845	73/9376	0.759990273162033	ADH1B/GSTM3/ADH5/GSTM4/GSTT2B	-0.64787733030422
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/845	17/9376	0.652697528715628	GGT5	-0.451057213213265
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/845	17/9376	0.652697528715628	GLUD1	-0.451057213213265
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/845	99/9376	0.784555615324846	C1S/CFH/C1R/CFI/HLA-DOB/CFD/KRT17	-0.678208174174018
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/845	34/9376	0.652697528715628	POLR2K/POLR2M	-0.638471362242963
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/845	76/9376	0.729990657116163	SCP2/LPL/ACADM/ME3/DBI	-0.743803359304591
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/845	154/9376	0.792561284868977	MOCS1/ALDH3A2/MTHFD2/MAT2A/CMPK2/MOCS2/ALAS1/DHFR/NME1/MTHFD2L/PANK1	-0.816867536548737
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/845	90/9376	0.739723865877712	ADCY3/ATP1B2/ADCY6/EPHX1/GNAS/ADCY4	-0.780827830684054
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/845	19/9376	0.583992525692931	PDHB	-0.571246616818769
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/845	35/9376	0.634049027895182	PFKM/HK2	-0.682612541122214
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/845	36/9376	0.616436554898093	PRIM2/RFC5	-0.725653082930755
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/845	66/9376	0.672476241707011	CYP7B1/HSD17B2/STS/HSD17B7	-0.840337913037735
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/845	37/9376	0.599776107468415	HK2/GFPT2	-0.767657871639899
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/845	54/9376	0.616436554898093	HES1/POLK/WDR48	-0.889597519015355
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/845	55/9376	0.60522861753631	DEGS1/CERS6/CERS2	-0.924080434336174
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/845	23/9376	0.482428608181116	ACAT1	-0.782118818814269
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/845	23/9376	0.482428608181116	RFC5	-0.782118818814269
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/845	43/9376	0.516086418054218	PLA2G2A/ACAT1	-1.00093396867863
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/845	26/9376	0.426763768775603	PLA2G2A	-0.92114610973529
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/845	26/9376	0.426763768775603	HES1	-0.92114610973529
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/845	28/9376	0.396280642434489	ATP6V1G1	-1.00685930206981
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/845	122/9376	0.636647589484916	SLC2A4/IRS1/SIRT1/PIK3CA/PFKM/PIK3R1/PIK3R3	-1.27132689654568
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/845	29/9376	0.382615792695368	CALM2	-1.0479303423292
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/845	30/9376	0.369861932938856	PLA2G2A	-1.08792129352011
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/845	49/9376	0.452892162782273	GXYLT2/C1GALT1C1L	-1.20840916189246
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/845	31/9376	0.357930902844054	ALDH3A2	-1.12690416373442
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/845	183/9376	0.66696414136515	RIOK2/RAN/NXT1/NOP10/NMD3/WDR3/RPP30/RCL1/XPO1/XRN1/NOB1	-1.43186453975567
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/845	51/9376	0.435131685810419	CHPT1/PLA2G2A	-1.2729809470782
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/845	32/9376	0.346745562130177	GABARAPL2	-1.16494377427642
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/845	100/9376	0.554792899408284	CSF1/KITLG/HLA-DOB/MME/ITGA6	-1.40862610953105
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/845	117/9376	0.569018358367471	ACTG1/BRD8/MEAF6/SMARCD3/SMARCE1/BCL7A	-1.47633080428756
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/845	36/9376	0.308218277449047	RPE	-1.30876272516239
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/845	36/9376	0.308218277449047	HK2	-1.30876272516239
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/845	36/9376	0.308218277449047	C1GALT1C1L	-1.30876272516239
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/845	56/9376	0.396280642434489	OSTC/MAN1A1	-1.42605140303745
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/845	195/9376	0.625920194204218	ACTG1/NFKB1/VDAC3/PRKCA/PIK3CA/HAT1/PIK3R1/PIK3R3/PPIF/VDAC2/VDAC1	-1.66130968805393
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/845	41/9376	0.270630682638187	ABRAXAS1	-1.47297806196317
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/845	191/9376	0.580934973202392	CALM2/GNB4/PPP1CB/GNAI3/KRAS/GNAS/NTRK2/SOS1/GNG11/HAT1	-1.84150347686348
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/845	44/9376	0.252178590640129	RFC5	-1.56477136235424
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/845	79/9376	0.280907797168751	ATP6V1G1/STX2	-2.01995052141056
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/845	370/9376	0.599776107468415	P2RY14/SSTR2/AVPR1A/OGFRL1/S1PR3/GHR/HTR1F/EDNRA/ADRA2A/CYSLTR2/AGTR1/GABBR1/CNR1/ADRA2C/EDNRB/PTGIR/CALCRL/P2RX5/NPY1R/HRH2	-2.47201968041227
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/845	143/9376	0.387967062523276	C7/C1S/C1R/HLA-DOB/CD40	-2.32105492498715
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/845	250/9376	0.48821775147929	LAPTM4B/CTSC/AP3M2/ATP6V1G1/VPS29/SLC36A4/VPS13C/AP1S2/TLR3/VPS26A/SORT1	-2.58124371683018
NA	NA	hsa04382	Cornified envelope formation	7/845	217/9376	0.357930902844054	S100A9/ELOVL4/EPHX2/COL4A1/KRT17/ITGA6/KRT6A	-3.01163008484036
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/845	449/9376	0.197699028742373	PRKG1/ADCY3/PDE1A/OR51E1/NCALD/CALM2/CAMK2D/RGS2	-5.48304414858864