ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0140662 ATP-dependent protein folding chaperone 20/1661 40/18639 0.5 5.61077664057797 2.15102842960746e-11 2.58338514395856e-08 GO:0005201 extracellular matrix structural constituent 42/1661 168/18639 0.25 2.80538832028898 5.13247817102755e-10 3.08205314170204e-07 GO:0051082 unfolded protein binding 34/1661 121/18639 0.28099173553719 3.15316373189505 8.4913067500796e-10 3.3993531356152e-07 GO:0044183 protein folding chaperone 23/1661 75/18639 0.306666666666667 3.44127633955448 7.6067067440405e-08 2.28391369989816e-05 GO:0031072 heat shock protein binding 32/1661 131/18639 0.244274809160305 2.74114278623656 1.02990832649884e-07 2.47383980025021e-05 GO:0140297 DNA-binding transcription factor binding 78/1661 488/18639 0.159836065573771 1.7936089260864 2.61277170186486e-07 5.22989802323282e-05 GO:0044389 ubiquitin-like protein ligase binding 56/1661 322/18639 0.173913043478261 1.95157448367929 8.80599427626811e-07 0.000151085701797114 GO:0051087 protein-folding chaperone binding 30/1661 134/18639 0.223880597014925 2.51228804801998 1.85584379621823e-06 0.000278608549907262 GO:0005518 collagen binding 20/1661 72/18639 0.277777777777778 3.11709813365443 3.00413845337041e-06 0.000400885586944208 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 57/1661 349/18639 0.163323782234957 1.83274652442948 5.36557972560874e-06 0.000644406125045609 GO:0031625 ubiquitin protein ligase binding 51/1661 302/18639 0.16887417218543 1.89503052098991 6.35370333644924e-06 0.000693708882461412 GO:0048407 platelet-derived growth factor binding 7/1661 11/18639 0.636363636363636 7.14098845164468 1.05427839363215e-05 0.00105515695896017 GO:0030020 extracellular matrix structural constituent conferring tensile strength 14/1661 44/18639 0.318181818181818 3.57049422582234 1.6688581973502e-05 0.00154176822693661 GO:0019838 growth factor binding 28/1661 136/18639 0.205882352941176 2.31031979317916 2.15508958176379e-05 0.00184875899121308 GO:0005525 GTP binding 57/1661 378/18639 0.150793650793651 1.69213898684097 5.74458397045131e-05 0.00459949689900802 GO:0001217 DNA-binding transcription repressor activity 45/1661 278/18639 0.161870503597122 1.81643848076265 6.28962504838132e-05 0.00472114980194122 GO:0005528 FK506 binding 6/1661 10/18639 0.6 6.73293196869356 7.60547540064013e-05 0.00511807650861571 GO:0019001 guanyl nucleotide binding 59/1661 400/18639 0.1475 1.6551791089705 8.09687374385499e-05 0.00511807650861571 GO:0032561 guanyl ribonucleotide binding 59/1661 400/18639 0.1475 1.6551791089705 8.09687374385499e-05 0.00511807650861571 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 67/1661 484/18639 0.138429752066116 1.55339683850712 0.00019148568009787 0.0114987150898771 GO:0051879 Hsp90 protein binding 12/1661 42/18639 0.285714285714286 3.20615808033027 0.000211667313463106 0.0121053544509138 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 42/1661 268/18639 0.156716417910448 1.75860163361399 0.00022461222109196 0.0122617853423384 GO:0005527 macrolide binding 6/1661 12/18639 0.5 5.61077664057797 0.000285990584141539 0.0144838244778914 GO:0001216 DNA-binding transcription activator activity 67/1661 491/18639 0.136456211812627 1.5312506514001 0.000289435293479928 0.0144838244778914 GO:0140416 transcription regulator inhibitor activity 10/1661 33/18639 0.303030303030303 3.40047069125937 0.000420061962329433 0.020179776670306 GO:0043021 ribonucleoprotein complex binding 30/1661 177/18639 0.169491525423729 1.90195818324677 0.000451036438528669 0.0207410937848746 GO:0001221 transcription coregulator binding 22/1661 115/18639 0.191304347826087 2.14673193204722 0.000469932393687195 0.0207410937848746 GO:0031994 insulin-like growth factor I binding 6/1661 13/18639 0.461538461538462 5.17917843745658 0.000491111070239444 0.0207410937848746 GO:0051537 2 iron, 2 sulfur cluster binding 9/1661 28/18639 0.321428571428571 3.60692784037155 0.000500825745013624 0.0207410937848746 GO:0070888 E-box binding 14/1661 59/18639 0.23728813559322 2.66274145654548 0.000542034736392649 0.0216994572802524 GO:0016849 phosphorus-oxygen lyase activity 8/1661 23/18639 0.347826086956522 3.90314896735858 0.000565548376962483 0.0219104387332885 GO:1990825 sequence-specific mRNA binding 6/1661 14/18639 0.428571428571429 4.8092371204954 0.000794814878118067 0.0298303958943687 GO:0043022 ribosome binding 21/1661 112/18639 0.1875 2.10404124021674 0.000822634646966894 0.0299389154850679 GO:0005520 insulin-like growth factor binding 7/1661 19/18639 0.368421052631579 4.13425647200482 0.000848838921684499 0.029983986615973 GO:0044325 transmembrane transporter binding 24/1661 136/18639 0.176470588235294 1.98027410843928 0.000899128819943425 0.0308529632214872 GO:0060590 ATPase regulator activity 12/1661 49/18639 0.244897959183673 2.74813549742594 0.000984220469059628 0.0320509842943336 GO:0003712 transcription coregulator activity 65/1661 495/18639 0.131313131313131 1.47353729954573 0.000987415835878721 0.0320509842943336 GO:0051371 muscle alpha-actinin binding 6/1661 15/18639 0.4 4.48862131246237 0.00122526350258222 0.0387247754368748 GO:0009055 electron transfer activity 21/1661 116/18639 0.181034482758621 2.03148809400237 0.00131235551045995 0.0404138196939078 GO:0016922 nuclear receptor binding 23/1661 137/18639 0.167883211678832 1.88391040486559 0.00224682173564694 0.0647579682220983 GO:0019003 GDP binding 15/1661 75/18639 0.2 2.24431065623119 0.00226398068488662 0.0647579682220983 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/1661 22/18639 0.318181818181818 3.57049422582234 0.00226464168636813 0.0647579682220983 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 14/1661 68/18639 0.205882352941176 2.31031979317916 0.00235709958494882 0.0658343395703148 GO:0003925 G protein activity 12/1661 54/18639 0.222222222222222 2.49367850692354 0.00241468078191371 0.0659098095245083 GO:0140693 molecular condensate scaffold activity 11/1661 48/18639 0.229166666666667 2.5716059602649 0.00279589646008581 0.0746193699680679 GO:0003924 GTPase activity 45/1661 331/18639 0.13595166163142 1.52558881465866 0.00286800751777359 0.0748799354096974 GO:0019207 kinase regulator activity 40/1661 287/18639 0.139372822299652 1.56397955138062 0.00306381687064054 0.0782902991838146 GO:0031690 adrenergic receptor binding 6/1661 18/18639 0.333333333333333 3.74051776038531 0.00359957111309348 0.0882262225882709 GO:0070064 proline-rich region binding 6/1661 18/18639 0.333333333333333 3.74051776038531 0.00359957111309348 0.0882262225882709 GO:0035035 histone acetyltransferase binding 7/1661 24/18639 0.291666666666667 3.27295304033715 0.00392435240715781 0.0942629448199305 GO:0042826 histone deacetylase binding 21/1661 127/18639 0.165354330708661 1.85553243231712 0.00409471239490515 0.0964264624760997 GO:0042805 actinin binding 9/1661 37/18639 0.243243243243243 2.72956701433523 0.00434202928163126 0.10028417629306 GO:0003954 NADH dehydrogenase activity 10/1661 44/18639 0.227272727272727 2.55035301844453 0.00456969353561885 0.103550979929778 GO:0003725 double-stranded RNA binding 14/1661 75/18639 0.186666666666667 2.09468994581577 0.00597314416924607 0.132847150875269 GO:0017124 SH3 domain binding 19/1661 115/18639 0.165217391304348 1.85399575949533 0.00618171631621996 0.134986205377821 GO:0051536 iron-sulfur cluster binding 14/1661 76/18639 0.184210526315789 2.06712823600241 0.0067363894213371 0.143088447948576 GO:0019887 protein kinase regulator activity 35/1661 255/18639 0.137254901960784 1.54021319545277 0.00679506471518289 0.143088447948576 GO:0004860 protein kinase inhibitor activity 15/1661 84/18639 0.178571428571429 2.00384880020642 0.0069101831648771 0.143088447948576 GO:0033218 amide binding 34/1661 247/18639 0.137651821862348 1.54466725327652 0.00723215328702386 0.147217221995181 GO:0051540 metal cluster binding 14/1661 77/18639 0.181818181818182 2.04028241475562 0.00757543714984661 0.151635000282763 GO:0000774 adenyl-nucleotide exchange factor activity 5/1661 15/18639 0.333333333333333 3.74051776038531 0.00784146160813673 0.154386809694626 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/1661 21/18639 0.285714285714286 3.20615808033027 0.00834605176569898 0.154844545380589 GO:0009975 cyclase activity 6/1661 21/18639 0.285714285714286 3.20615808033027 0.00834605176569898 0.154844545380589 GO:0005522 profilin binding 4/1661 10/18639 0.4 4.48862131246237 0.00850935886354609 0.154844545380589 GO:0030957 Tat protein binding 4/1661 10/18639 0.4 4.48862131246237 0.00850935886354609 0.154844545380589 GO:0043121 neurotrophin binding 4/1661 10/18639 0.4 4.48862131246237 0.00850935886354609 0.154844545380589 GO:0008137 NADH dehydrogenase (ubiquinone) activity 9/1661 41/18639 0.219512195121951 2.46326779342447 0.00885868391447152 0.158795214645974 GO:0046332 SMAD binding 14/1661 79/18639 0.177215189873418 1.98862969539472 0.00950128285274105 0.167809422149147 GO:0046966 nuclear thyroid hormone receptor binding 7/1661 28/18639 0.25 2.80538832028898 0.00980499762490199 0.16822574496439 GO:0051393 alpha-actinin binding 7/1661 28/18639 0.25 2.80538832028898 0.00980499762490199 0.16822574496439 GO:0016859 cis-trans isomerase activity 9/1661 42/18639 0.214285714285714 2.4046185602477 0.0104046079603874 0.175999072682047 GO:0005159 insulin-like growth factor receptor binding 5/1661 16/18639 0.3125 3.50673540036123 0.0105814171263109 0.176503916231937 GO:0043236 laminin binding 7/1661 29/18639 0.241379310344828 2.70865079200316 0.0119524943974628 0.182190945624628 GO:0004857 enzyme inhibitor activity 51/1661 416/18639 0.122596153846154 1.3757192724494 0.0122152158701164 0.182190945624628 GO:0003713 transcription coactivator activity 34/1661 256/18639 0.1328125 1.49036254515352 0.012217703400963 0.182190945624628 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/1661 36/18639 0.222222222222222 2.49367850692354 0.0123350057797844 0.182190945624628 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/1661 36/18639 0.222222222222222 2.49367850692354 0.0123350057797844 0.182190945624628 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/1661 36/18639 0.222222222222222 2.49367850692354 0.0123350057797844 0.182190945624628 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 11/1661 58/18639 0.189655172413793 2.12822562228819 0.0124153139513288 0.182190945624628 GO:0004016 adenylate cyclase activity 4/1661 11/18639 0.363636363636364 4.08056482951125 0.012439348493938 0.182190945624628 GO:0034713 type I transforming growth factor beta receptor binding 4/1661 11/18639 0.363636363636364 4.08056482951125 0.012439348493938 0.182190945624628 GO:0140537 transcription regulator activator activity 4/1661 11/18639 0.363636363636364 4.08056482951125 0.012439348493938 0.182190945624628 GO:0019210 kinase inhibitor activity 15/1661 90/18639 0.166666666666667 1.87025888019265 0.0129482054870599 0.187358973372999 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/1661 23/18639 0.260869565217391 2.92736172551894 0.0133154930876415 0.188377895302055 GO:0030544 Hsp70 protein binding 10/1661 51/18639 0.196078431372549 2.20030456493254 0.0133323239805784 0.188377895302055 GO:0004029 aldehyde dehydrogenase (NAD+) activity 5/1661 17/18639 0.294117647058824 3.3004568473988 0.0139098336203854 0.190169351797321 GO:0070402 NADPH binding 5/1661 17/18639 0.294117647058824 3.3004568473988 0.0139098336203854 0.190169351797321 GO:0001046 core promoter sequence-specific DNA binding 9/1661 44/18639 0.204545454545455 2.29531771660008 0.0140924831889771 0.190169351797321 GO:0001223 transcription coactivator binding 9/1661 44/18639 0.204545454545455 2.29531771660008 0.0140924831889771 0.190169351797321 GO:0003714 transcription corepressor activity 28/1661 204/18639 0.137254901960784 1.54021319545277 0.0143244115437894 0.190724066915656 GO:0050840 extracellular matrix binding 12/1661 67/18639 0.17910447761194 2.00983043841599 0.0144511990752079 0.190724066915656 GO:0005080 protein kinase C binding 10/1661 52/18639 0.192307692307692 2.15799101560691 0.0152257693025563 0.195559345056216 GO:0001098 basal transcription machinery binding 11/1661 60/18639 0.183333333333333 2.05728476821192 0.0158781500413297 0.195559345056216 GO:0001099 basal RNA polymerase II transcription machinery binding 11/1661 60/18639 0.183333333333333 2.05728476821192 0.0158781500413297 0.195559345056216 GO:0051117 ATPase binding 14/1661 84/18639 0.166666666666667 1.87025888019265 0.0160078904111074 0.195559345056216 GO:0005178 integrin binding 23/1661 161/18639 0.142857142857143 1.60307904016513 0.0160507409626372 0.195559345056216 GO:1990841 promoter-specific chromatin binding 12/1661 68/18639 0.176470588235294 1.98027410843928 0.0161678344177325 0.195559345056216 GO:0098631 cell adhesion mediator activity 13/1661 76/18639 0.171052631578947 1.91947621914509 0.0161873863778431 0.195559345056216 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/1661 24/18639 0.25 2.80538832028898 0.0164458733144694 0.195559345056216 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/1661 24/18639 0.25 2.80538832028898 0.0164458733144694 0.195559345056216 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/1661 24/18639 0.25 2.80538832028898 0.0164458733144694 0.195559345056216 GO:0017147 Wnt-protein binding 7/1661 31/18639 0.225806451612903 2.53389912800295 0.0172292837711868 0.201862786705433 GO:0140296 general transcription initiation factor binding 10/1661 53/18639 0.188679245283019 2.11727420399168 0.0173121290846458 0.201862786705433 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 5/1661 18/18639 0.277777777777778 3.11709813365443 0.0178753192001131 0.204459603422246 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/1661 18/18639 0.277777777777778 3.11709813365443 0.0178753192001131 0.204459603422246 GO:0016887 ATP hydrolysis activity 50/1661 417/18639 0.119904076738609 1.34550998575011 0.0190166916230276 0.215462704143926 GO:0051287 NAD binding 10/1661 54/18639 0.185185185185185 2.07806542243628 0.0196020034942861 0.220018136193045 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/1661 39/18639 0.205128205128205 2.30185708331404 0.0197851446368434 0.220018136193045 GO:0043425 bHLH transcription factor binding 7/1661 32/18639 0.21875 2.45471478025286 0.0204036618711969 0.224814659700069 GO:0003756 protein disulfide isomerase activity 5/1661 19/18639 0.263157894736842 2.9530403371463 0.0225203832655747 0.241490895553171 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/1661 19/18639 0.263157894736842 2.9530403371463 0.0225203832655747 0.241490895553171 GO:0120227 acyl-CoA binding 5/1661 19/18639 0.263157894736842 2.9530403371463 0.0225203832655747 0.241490895553171 GO:0005035 death receptor activity 4/1661 13/18639 0.307692307692308 3.45278562497106 0.0233425728175351 0.248092300476634 GO:0004713 protein tyrosine kinase activity 20/1661 140/18639 0.142857142857143 1.60307904016513 0.0235673478202375 0.248284076597414 GO:0071889 14-3-3 protein binding 7/1661 33/18639 0.212121212121212 2.38032948388156 0.0239632970410524 0.24870058082525 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/1661 26/18639 0.230769230769231 2.58958921872829 0.024151358805067 0.24870058082525 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/1661 48/18639 0.1875 2.10404124021674 0.0242281165333508 0.24870058082525 GO:0016247 channel regulator activity 23/1661 168/18639 0.136904761904762 1.53628408015825 0.0253308130298414 0.257816156346097 GO:0016004 phospholipase activator activity 5/1661 20/18639 0.25 2.80538832028898 0.0278808503952679 0.279040844372639 GO:0052745 inositol phosphate phosphatase activity 5/1661 20/18639 0.25 2.80538832028898 0.0278808503952679 0.279040844372639 GO:0141108 transporter regulator activity 23/1661 170/18639 0.135294117647059 1.51821014980345 0.028620885542422 0.282054657932903 GO:0001671 ATPase activator activity 6/1661 27/18639 0.222222222222222 2.49367850692354 0.0287794338258269 0.282054657932903 GO:0005516 calmodulin binding 27/1661 207/18639 0.130434782608696 1.46368086275947 0.0288865303295147 0.282054657932903 GO:0046030 inositol trisphosphate phosphatase activity 4/1661 14/18639 0.285714285714286 3.20615808033027 0.0304251770487017 0.294682561576538 GO:0022853 active monoatomic ion transmembrane transporter activity 17/1661 118/18639 0.144067796610169 1.61666445575975 0.0324608746051087 0.311884083205884 GO:0051019 mitogen-activated protein kinase binding 6/1661 28/18639 0.214285714285714 2.4046185602477 0.0339542800624429 0.323643574245983 GO:0004879 nuclear receptor activity 10/1661 59/18639 0.169491525423729 1.90195818324677 0.0344541943662329 0.324992685919863 GO:0005021 vascular endothelial growth factor receptor activity 9/1661 51/18639 0.176470588235294 1.98027410843928 0.034637022312858 0.324992685919863 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 18/1661 128/18639 0.140625 1.57803093016255 0.0350594751025998 0.326406430993972 GO:0051219 phosphoprotein binding 14/1661 93/18639 0.150537634408602 1.6892660853353 0.0356226307418336 0.329098304007247 GO:0000287 magnesium ion binding 29/1661 230/18639 0.126086956521739 1.41489150066749 0.035939314730323 0.32948944268029 GO:0055106 ubiquitin-protein transferase regulator activity 7/1661 36/18639 0.194444444444444 2.1819686935581 0.0371347959303316 0.335173495718431 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/1661 60/18639 0.166666666666667 1.87025888019265 0.0381694032312135 0.335173495718431 GO:0098531 ligand-modulated transcription factor activity 10/1661 60/18639 0.166666666666667 1.87025888019265 0.0381694032312135 0.335173495718431 GO:0003735 structural constituent of ribosome 23/1661 175/18639 0.131428571428571 1.47483271695192 0.0382597641811963 0.335173495718431 GO:0031386 protein tag activity 4/1661 15/18639 0.266666666666667 2.99241420830825 0.0386374372089071 0.335173495718431 GO:0140776 protein-containing complex destabilizing activity 4/1661 15/18639 0.266666666666667 2.99241420830825 0.0386374372089071 0.335173495718431 GO:0141047 molecular tag activity 4/1661 15/18639 0.266666666666667 2.99241420830825 0.0386374372089071 0.335173495718431 GO:0015399 primary active transmembrane transporter activity 22/1661 166/18639 0.132530120481928 1.48719380834597 0.0387919366401848 0.335173495718431 GO:0005539 glycosaminoglycan binding 30/1661 242/18639 0.12396694214876 1.39110164642429 0.0404959556852746 0.347397448414392 GO:0099106 ion channel regulator activity 21/1661 160/18639 0.13125 1.47282886815172 0.046664723374155 0.391293428940161 GO:0016651 oxidoreductase activity, acting on NAD(P)H 13/1661 88/18639 0.147727272727273 1.65772946198894 0.0476510134141012 0.391293428940161 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 9/1661 54/18639 0.166666666666667 1.87025888019265 0.0477691220798908 0.391293428940161 GO:0000062 fatty-acyl-CoA binding 4/1661 16/18639 0.25 2.80538832028898 0.0479894439031059 0.391293428940161 GO:0016722 oxidoreductase activity, acting on metal ions 4/1661 16/18639 0.25 2.80538832028898 0.0479894439031059 0.391293428940161 GO:0043023 ribosomal large subunit binding 4/1661 16/18639 0.25 2.80538832028898 0.0479894439031059 0.391293428940161 GO:0042171 lysophosphatidic acid acyltransferase activity 5/1661 23/18639 0.217391304347826 2.43946810459912 0.0485058060723205 0.391293428940161 GO:0071617 lysophospholipid acyltransferase activity 5/1661 23/18639 0.217391304347826 2.43946810459912 0.0485058060723205 0.391293428940161 GO:0035401 histone H3Y41 kinase activity 16/1661 115/18639 0.139130434782609 1.56125958694343 0.0488709528235006 0.391293428940161 GO:0140801 histone H2AXY142 kinase activity 16/1661 115/18639 0.139130434782609 1.56125958694343 0.0488709528235006 0.391293428940161 GO:0019902 phosphatase binding 24/1661 190/18639 0.126315789473684 1.41745936183022 0.0515944988362818 0.402878431070416 GO:0004090 carbonyl reductase (NADPH) activity 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:0015279 store-operated calcium channel activity 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:0031996 thioesterase binding 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:0043422 protein kinase B binding 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:1905394 retromer complex binding 3/1661 10/18639 0.3 3.36646598434678 0.0526660396986306 0.402878431070416 GO:0005540 hyaluronic acid binding 5/1661 24/18639 0.208333333333333 2.33782360024082 0.0569426304822814 0.424770802541739 GO:0048027 mRNA 5'-UTR binding 5/1661 24/18639 0.208333333333333 2.33782360024082 0.0569426304822814 0.424770802541739 GO:0060229 lipase activator activity 5/1661 24/18639 0.208333333333333 2.33782360024082 0.0569426304822814 0.424770802541739 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 5/1661 24/18639 0.208333333333333 2.33782360024082 0.0569426304822814 0.424770802541739 GO:0048038 quinone binding 4/1661 17/18639 0.235294117647059 2.64036547791904 0.0584754778362507 0.425630599280831 GO:0051787 misfolded protein binding 4/1661 17/18639 0.235294117647059 2.64036547791904 0.0584754778362507 0.425630599280831 GO:0070403 NAD+ binding 4/1661 17/18639 0.235294117647059 2.64036547791904 0.0584754778362507 0.425630599280831 GO:1901567 fatty acid derivative binding 4/1661 17/18639 0.235294117647059 2.64036547791904 0.0584754778362507 0.425630599280831 GO:0140142 nucleocytoplasmic carrier activity 6/1661 32/18639 0.1875 2.10404124021674 0.0604242851977842 0.437166063388788 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/1661 40/18639 0.175 1.96377182420229 0.0610210893978492 0.438840289621658 GO:0019211 phosphatase activator activity 5/1661 25/18639 0.2 2.24431065623119 0.0661661666736448 0.462323918916868 GO:0001222 transcription corepressor binding 8/1661 49/18639 0.163265306122449 1.83209033161729 0.0663922358270769 0.462323918916868 GO:0019209 kinase activator activity 19/1661 148/18639 0.128378378378378 1.44060481312137 0.0673691826161361 0.462323918916868 GO:0008526 phosphatidylinositol transfer activity 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0010854 adenylate cyclase regulator activity 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0019107 myristoyltransferase activity 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0019215 intermediate filament binding 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0034056 estrogen response element binding 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0097493 structural molecule activity conferring elasticity 3/1661 11/18639 0.272727272727273 3.06042362213344 0.0677510489003903 0.462323918916868 GO:0008308 voltage-gated monoatomic anion channel activity 4/1661 18/18639 0.222222222222222 2.49367850692354 0.0700755231608614 0.472812939978621 GO:0017128 phospholipid scramblase activity 4/1661 18/18639 0.222222222222222 2.49367850692354 0.0700755231608614 0.472812939978621 GO:0042562 hormone binding 13/1661 94/18639 0.138297872340426 1.55191694313859 0.0734997693034605 0.49314649683495 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 16/1661 122/18639 0.131147540983607 1.47167911884012 0.0755241188686304 0.494935667413888 GO:0048487 beta-tubulin binding 7/1661 42/18639 0.166666666666667 1.87025888019265 0.0758191747384053 0.494935667413888 GO:0005160 transforming growth factor beta receptor binding 5/1661 26/18639 0.192307692307692 2.15799101560691 0.0761696923566395 0.494935667413888 GO:0070006 metalloaminopeptidase activity 5/1661 26/18639 0.192307692307692 2.15799101560691 0.0761696923566395 0.494935667413888 GO:0070412 R-SMAD binding 5/1661 26/18639 0.192307692307692 2.15799101560691 0.0761696923566395 0.494935667413888 GO:0045309 protein phosphorylated amino acid binding 9/1661 59/18639 0.152542372881356 1.71176236492209 0.0762390495183758 0.494935667413888 GO:0015035 protein-disulfide reductase activity 6/1661 34/18639 0.176470588235294 1.98027410843928 0.0772266245251359 0.495389475075878 GO:0030332 cyclin binding 6/1661 34/18639 0.176470588235294 1.98027410843928 0.0772266245251359 0.495389475075878 GO:0001664 G protein-coupled receptor binding 34/1661 297/18639 0.114478114478114 1.28462226114243 0.0779759197265299 0.495389475075878 GO:0005548 phospholipid transporter activity 10/1661 68/18639 0.147058823529412 1.6502284236994 0.0779955094106916 0.495389475075878 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 17/1661 132/18639 0.128787878787879 1.44520004378523 0.0783713574224952 0.495389475075878 GO:0016853 isomerase activity 22/1661 180/18639 0.122222222222222 1.37152317880795 0.0800426857825486 0.499594196155863 GO:0005030 neurotrophin receptor activity 8/1661 51/18639 0.156862745098039 1.76024365194603 0.0803234745505003 0.499594196155863 GO:0097001 ceramide binding 4/1661 19/18639 0.210526315789474 2.36243226971704 0.0827568937996046 0.499594196155863 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 9/1661 60/18639 0.15 1.68323299217339 0.082957222392581 0.499594196155863 GO:0000995 RNA polymerase III general transcription initiation factor activity 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0003995 acyl-CoA dehydrogenase activity 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0005049 nuclear export signal receptor activity 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0005165 neurotrophin receptor binding 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0035497 cAMP response element binding 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0070679 inositol 1,4,5 trisphosphate binding 3/1661 12/18639 0.25 2.80538832028898 0.0845472616964947 0.499594196155863 GO:0019199 transmembrane receptor protein kinase activity 11/1661 78/18639 0.141025641025641 1.5825267447784 0.0847309671211803 0.499594196155863 GO:0005154 epidermal growth factor receptor binding 6/1661 35/18639 0.171428571428571 1.92369484819816 0.0865191783209221 0.499594196155863 GO:0043015 gamma-tubulin binding 6/1661 35/18639 0.171428571428571 1.92369484819816 0.0865191783209221 0.499594196155863 GO:0061631 ubiquitin conjugating enzyme activity 6/1661 35/18639 0.171428571428571 1.92369484819816 0.0865191783209221 0.499594196155863 GO:0008266 poly(U) RNA binding 5/1661 27/18639 0.185185185185185 2.07806542243628 0.086940205659097 0.499594196155863 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/1661 27/18639 0.185185185185185 2.07806542243628 0.086940205659097 0.499594196155863 GO:0023026 MHC class II protein complex binding 5/1661 27/18639 0.185185185185185 2.07806542243628 0.086940205659097 0.499594196155863 GO:0003779 actin binding 48/1661 443/18639 0.108352144469526 1.21587936229229 0.090443597073081 0.517251238498906 GO:0005003 ephrin receptor activity 8/1661 53/18639 0.150943396226415 1.69381936319335 0.0958588396650938 0.532663873285377 GO:0005005 transmembrane-ephrin receptor activity 8/1661 53/18639 0.150943396226415 1.69381936319335 0.0958588396650938 0.532663873285377 GO:0005246 calcium channel regulator activity 8/1661 53/18639 0.150943396226415 1.69381936319335 0.0958588396650938 0.532663873285377 GO:0038064 collagen receptor activity 8/1661 53/18639 0.150943396226415 1.69381936319335 0.0958588396650938 0.532663873285377 GO:0016408 C-acyltransferase activity 4/1661 20/18639 0.2 2.24431065623119 0.0964759046506888 0.532663873285377 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/1661 20/18639 0.2 2.24431065623119 0.0964759046506888 0.532663873285377 GO:0043024 ribosomal small subunit binding 4/1661 20/18639 0.2 2.24431065623119 0.0964759046506888 0.532663873285377 GO:0019208 phosphatase regulator activity 15/1661 117/18639 0.128205128205128 1.43866067707127 0.0966866980651226 0.532663873285377 GO:0015631 tubulin binding 42/1661 385/18639 0.109090909090909 1.22416944885337 0.0992521040778741 0.54430035158688 GO:0140303 intramembrane lipid transporter activity 7/1661 45/18639 0.155555555555556 1.74557495484648 0.10160699975643 0.546330065120413 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/1661 13/18639 0.230769230769231 2.58958921872829 0.102908668360183 0.546330065120413 GO:0039706 co-receptor binding 3/1661 13/18639 0.230769230769231 2.58958921872829 0.102908668360183 0.546330065120413 GO:0043560 insulin receptor substrate binding 3/1661 13/18639 0.230769230769231 2.58958921872829 0.102908668360183 0.546330065120413 GO:0070700 BMP receptor binding 3/1661 13/18639 0.230769230769231 2.58958921872829 0.102908668360183 0.546330065120413 GO:0097157 pre-mRNA intronic binding 3/1661 13/18639 0.230769230769231 2.58958921872829 0.102908668360183 0.546330065120413 GO:0005126 cytokine receptor binding 31/1661 275/18639 0.112727272727273 1.26497509714849 0.103261386163475 0.546330065120413 GO:1901681 sulfur compound binding 31/1661 275/18639 0.112727272727273 1.26497509714849 0.103261386163475 0.546330065120413 GO:0050661 NADP binding 8/1661 54/18639 0.148148148148148 1.66245233794903 0.104222268810347 0.548995372110642 GO:0005507 copper ion binding 9/1661 63/18639 0.142857142857143 1.60307904016513 0.105172100562345 0.551579444433958 GO:0072341 modified amino acid binding 12/1661 91/18639 0.131868131868132 1.47976526784474 0.109225636833968 0.56340346722599 GO:0004180 carboxypeptidase activity 7/1661 46/18639 0.152173913043478 1.70762767321938 0.111141213451162 0.56340346722599 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/1661 46/18639 0.152173913043478 1.70762767321938 0.111141213451162 0.56340346722599 GO:0001846 opsonin binding 4/1661 21/18639 0.19047619047619 2.13743872022018 0.111179535164496 0.56340346722599 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/1661 21/18639 0.19047619047619 2.13743872022018 0.111179535164496 0.56340346722599 GO:0005123 death receptor binding 4/1661 21/18639 0.19047619047619 2.13743872022018 0.111179535164496 0.56340346722599 GO:0035613 RNA stem-loop binding 4/1661 21/18639 0.19047619047619 2.13743872022018 0.111179535164496 0.56340346722599 GO:0072542 protein phosphatase activator activity 4/1661 21/18639 0.19047619047619 2.13743872022018 0.111179535164496 0.56340346722599 GO:0098632 cell-cell adhesion mediator activity 8/1661 55/18639 0.145454545454545 1.6322259318045 0.112976660585366 0.57010491329002 GO:0005109 frizzled binding 6/1661 38/18639 0.157894736842105 1.77182420228778 0.117852864918768 0.589249789811261 GO:0008135 translation factor activity, RNA binding 11/1661 83/18639 0.132530120481928 1.48719380834597 0.118356083385482 0.589249789811261 GO:0003697 single-stranded DNA binding 15/1661 121/18639 0.12396694214876 1.39110164642429 0.119547805837654 0.589249789811261 GO:0001784 phosphotyrosine residue binding 7/1661 47/18639 0.148936170212766 1.67129516953386 0.12113019062759 0.589249789811261 GO:0019843 rRNA binding 9/1661 65/18639 0.138461538461538 1.55375353123698 0.121674024009148 0.589249789811261 GO:0004065 arylsulfatase activity 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:0005161 platelet-derived growth factor receptor binding 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:0008191 metalloendopeptidase inhibitor activity 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:0042043 neurexin family protein binding 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:0042813 Wnt receptor activity 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:1901612 cardiolipin binding 3/1661 14/18639 0.214285714285714 2.4046185602477 0.122676893263314 0.589249789811261 GO:0008187 poly-pyrimidine tract binding 5/1661 30/18639 0.166666666666667 1.87025888019265 0.123639423007858 0.589249789811261 GO:0033612 receptor serine/threonine kinase binding 5/1661 30/18639 0.166666666666667 1.87025888019265 0.123639423007858 0.589249789811261 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/1661 30/18639 0.166666666666667 1.87025888019265 0.123639423007858 0.589249789811261 GO:0180051 translation factor activity 11/1661 84/18639 0.130952380952381 1.46948912015137 0.12587096485091 0.597513947770526 GO:0008201 heparin binding 20/1661 172/18639 0.116279069767442 1.3048317768786 0.132316700943642 0.625639204068163 GO:0004532 RNA exonuclease activity 6/1661 40/18639 0.15 1.68323299217339 0.141467090343251 0.636781533171865 GO:0015036 disulfide oxidoreductase activity 6/1661 40/18639 0.15 1.68323299217339 0.141467090343251 0.636781533171865 GO:0005004 GPI-linked ephrin receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0005008 hepatocyte growth factor receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0005009 insulin receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0005011 macrophage colony-stimulating factor receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0005020 stem cell factor receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0008288 boss receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0036332 placental growth factor receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0038062 protein tyrosine kinase collagen receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0060175 brain-derived neurotrophic factor receptor activity 7/1661 49/18639 0.142857142857143 1.60307904016513 0.142423946765604 0.636781533171865 GO:0031681 G-protein beta-subunit binding 4/1661 23/18639 0.173913043478261 1.95157448367929 0.14329151712593 0.636781533171865 GO:0005523 tropomyosin binding 3/1661 15/18639 0.2 2.24431065623119 0.143686757276915 0.636781533171865 GO:0008242 omega peptidase activity 3/1661 15/18639 0.2 2.24431065623119 0.143686757276915 0.636781533171865 GO:0042809 nuclear vitamin D receptor binding 3/1661 15/18639 0.2 2.24431065623119 0.143686757276915 0.636781533171865 GO:0048531 beta-1,3-galactosyltransferase activity 3/1661 15/18639 0.2 2.24431065623119 0.143686757276915 0.636781533171865 GO:0030145 manganese ion binding 9/1661 68/18639 0.132352941176471 1.48520558132946 0.148865406326474 0.651376253830282 GO:0140223 general transcription initiation factor activity 9/1661 68/18639 0.132352941176471 1.48520558132946 0.148865406326474 0.651376253830282 GO:0046982 protein heterodimerization activity 39/1661 369/18639 0.105691056910569 1.18601782646363 0.150142664649941 0.651376253830282 GO:0030515 snoRNA binding 5/1661 32/18639 0.15625 1.75336770018061 0.151464221675549 0.651376253830282 GO:0001786 phosphatidylserine binding 8/1661 59/18639 0.135593220338983 1.52156654659741 0.151752450608958 0.651376253830282 GO:0070063 RNA polymerase binding 8/1661 59/18639 0.135593220338983 1.52156654659741 0.151752450608958 0.651376253830282 GO:0005006 epidermal growth factor receptor activity 7/1661 50/18639 0.14 1.57101745936183 0.153699965874632 0.651376253830282 GO:0005007 fibroblast growth factor receptor activity 7/1661 50/18639 0.14 1.57101745936183 0.153699965874632 0.651376253830282 GO:0005017 platelet-derived growth factor receptor activity 7/1661 50/18639 0.14 1.57101745936183 0.153699965874632 0.651376253830282 GO:0005019 platelet-derived growth factor beta-receptor activity 7/1661 50/18639 0.14 1.57101745936183 0.153699965874632 0.651376253830282 GO:0032813 tumor necrosis factor receptor superfamily binding 7/1661 50/18639 0.14 1.57101745936183 0.153699965874632 0.651376253830282 GO:0042169 SH2 domain binding 6/1661 41/18639 0.146341463414634 1.64217852894965 0.154030687833306 0.651376253830282 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/1661 41/18639 0.146341463414634 1.64217852894965 0.154030687833306 0.651376253830282 GO:0050431 transforming growth factor beta binding 4/1661 24/18639 0.166666666666667 1.87025888019265 0.160561294454659 0.669398389751397 GO:0003743 translation initiation factor activity 7/1661 51/18639 0.137254901960784 1.54021319545277 0.165373498585289 0.669398389751397 GO:0005010 insulin-like growth factor receptor activity 7/1661 51/18639 0.137254901960784 1.54021319545277 0.165373498585289 0.669398389751397 GO:0003688 DNA replication origin binding 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0008142 oxysterol binding 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0030275 LRR domain binding 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0070411 I-SMAD binding 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0097027 ubiquitin-protein transferase activator activity 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0140328 floppase activity 3/1661 16/18639 0.1875 2.10404124021674 0.165770752670871 0.669398389751397 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/1661 33/18639 0.151515151515152 1.70023534562969 0.166274488580042 0.669398389751397 GO:0042277 peptide binding 27/1661 249/18639 0.108433734939759 1.21679493410125 0.166415294334647 0.669398389751397 GO:0140104 molecular carrier activity 27/1661 249/18639 0.108433734939759 1.21679493410125 0.166415294334647 0.669398389751397 GO:0035198 miRNA binding 6/1661 42/18639 0.142857142857143 1.60307904016513 0.167065940015789 0.669398389751397 GO:0042056 chemoattractant activity 6/1661 42/18639 0.142857142857143 1.60307904016513 0.167065940015789 0.669398389751397 GO:0003727 single-stranded RNA binding 11/1661 89/18639 0.123595505617978 1.38693355160354 0.167210255558217 0.669398389751397 GO:0042578 phosphoric ester hydrolase activity 38/1661 363/18639 0.104683195592287 1.17470805698051 0.168243286614391 0.671296303069382 GO:0030295 protein kinase activator activity 16/1661 139/18639 0.115107913669065 1.29168958632011 0.174270879478941 0.689999790346056 GO:0070851 growth factor receptor binding 16/1661 139/18639 0.115107913669065 1.29168958632011 0.174270879478941 0.689999790346056 GO:0001848 complement binding 4/1661 25/18639 0.16 1.79544852498495 0.1785413187939 0.689999790346056 GO:0004709 MAP kinase kinase kinase activity 4/1661 25/18639 0.16 1.79544852498495 0.1785413187939 0.689999790346056 GO:0008139 nuclear localization sequence binding 4/1661 25/18639 0.16 1.79544852498495 0.1785413187939 0.689999790346056 GO:0015271 outward rectifier potassium channel activity 4/1661 25/18639 0.16 1.79544852498495 0.1785413187939 0.689999790346056 GO:0017025 TBP-class protein binding 4/1661 25/18639 0.16 1.79544852498495 0.1785413187939 0.689999790346056 GO:0048156 tau protein binding 6/1661 43/18639 0.13953488372093 1.56579813225432 0.180545905810878 0.689999790346056 GO:0032182 ubiquitin-like protein binding 14/1661 120/18639 0.116666666666667 1.30918121613486 0.180908855627083 0.689999790346056 GO:0033192 calmodulin-dependent protein phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0140791 histone H2AXS140 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:1990439 MAP kinase serine/threonine phosphatase activity 10/1661 81/18639 0.123456790123457 1.38537694829086 0.182697696361404 0.689999790346056 GO:0016791 phosphatase activity 29/1661 273/18639 0.106227106227106 1.19203313243048 0.184259344810726 0.693716216669849 GO:0008484 sulfuric ester hydrolase activity 3/1661 17/18639 0.176470588235294 1.98027410843928 0.18876259727829 0.70404931469325 GO:0032183 SUMO binding 3/1661 17/18639 0.176470588235294 1.98027410843928 0.18876259727829 0.70404931469325 GO:0036041 long-chain fatty acid binding 3/1661 17/18639 0.176470588235294 1.98027410843928 0.18876259727829 0.70404931469325 GO:0016860 intramolecular oxidoreductase activity 7/1661 53/18639 0.132075471698113 1.48209194279418 0.189838703083272 0.705870843352972 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 10/1661 82/18639 0.121951219512195 1.36848210745804 0.192641607708028 0.711884833407206 GO:0033549 MAP kinase phosphatase activity 10/1661 82/18639 0.121951219512195 1.36848210745804 0.192641607708028 0.711884833407206 GO:0016248 channel inhibitor activity 6/1661 44/18639 0.136363636363636 1.53021181106672 0.194442012957558 0.71319989301438 GO:0008083 growth factor activity 18/1661 162/18639 0.111111111111111 1.24683925346177 0.194927983830311 0.71319989301438 GO:0008238 exopeptidase activity 12/1661 102/18639 0.117647058823529 1.32018273895952 0.196180737671022 0.71319989301438 GO:0005112 Notch binding 4/1661 26/18639 0.153846153846154 1.72639281248553 0.197154341782493 0.71319989301438 GO:0050681 nuclear androgen receptor binding 4/1661 26/18639 0.153846153846154 1.72639281248553 0.197154341782493 0.71319989301438 GO:0052742 phosphatidylinositol kinase activity 4/1661 26/18639 0.153846153846154 1.72639281248553 0.197154341782493 0.71319989301438 GO:0097602 cullin family protein binding 4/1661 26/18639 0.153846153846154 1.72639281248553 0.197154341782493 0.71319989301438 GO:0043539 protein serine/threonine kinase activator activity 9/1661 73/18639 0.123287671232877 1.38347917164936 0.200138867246792 0.721822160851044 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/1661 83/18639 0.120481927710843 1.35199437122361 0.202817706930295 0.729293610848155 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1661 45/18639 0.133333333333333 1.49620710415412 0.208724322680809 0.732664168027562 GO:0051539 4 iron, 4 sulfur cluster binding 6/1661 45/18639 0.133333333333333 1.49620710415412 0.208724322680809 0.732664168027562 GO:0141110 transporter inhibitor activity 6/1661 45/18639 0.133333333333333 1.49620710415412 0.208724322680809 0.732664168027562 GO:0019903 protein phosphatase binding 16/1661 144/18639 0.111111111111111 1.24683925346177 0.212070498670146 0.732664168027562 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1661 18/18639 0.166666666666667 1.87025888019265 0.212500012101776 0.732664168027562 GO:0004706 JUN kinase kinase kinase activity 3/1661 18/18639 0.166666666666667 1.87025888019265 0.212500012101776 0.732664168027562 GO:0008525 phosphatidylcholine transporter activity 3/1661 18/18639 0.166666666666667 1.87025888019265 0.212500012101776 0.732664168027562 GO:0034185 apolipoprotein binding 3/1661 18/18639 0.166666666666667 1.87025888019265 0.212500012101776 0.732664168027562 GO:1901611 phosphatidylglycerol binding 3/1661 18/18639 0.166666666666667 1.87025888019265 0.212500012101776 0.732664168027562 GO:0017018 myosin phosphatase activity 10/1661 84/18639 0.119047619047619 1.33589920013761 0.213215915319401 0.732664168027562 GO:0000993 RNA polymerase II complex binding 5/1661 36/18639 0.138888888888889 1.55854906682721 0.213782662478665 0.732664168027562 GO:0045505 dynein intermediate chain binding 5/1661 36/18639 0.138888888888889 1.55854906682721 0.213782662478665 0.732664168027562 GO:0016410 N-acyltransferase activity 11/1661 94/18639 0.117021276595745 1.31316049034803 0.214294665379032 0.732664168027562 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/1661 27/18639 0.148148148148148 1.66245233794903 0.21632201763004 0.732664168027562 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0004935 adrenergic receptor activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0005031 tumor necrosis factor receptor activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0005131 growth hormone receptor binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0005381 iron ion transmembrane transporter activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0031434 mitogen-activated protein kinase kinase binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0031720 haptoglobin binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0043295 glutathione binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0050815 phosphoserine residue binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0070513 death domain binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0098505 G-rich strand telomeric DNA binding 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:1990757 ubiquitin ligase activator activity 2/1661 10/18639 0.2 2.24431065623119 0.222056417287288 0.732664168027562 GO:0030291 protein serine/threonine kinase inhibitor activity 6/1661 46/18639 0.130434782608696 1.46368086275947 0.223361789065255 0.734952078540744 GO:0019212 phosphatase inhibitor activity 7/1661 56/18639 0.125 1.40269416014449 0.22902202813401 0.750190765573203 GO:0022829 wide pore channel activity 5/1661 37/18639 0.135135135135135 1.51642611907513 0.230491584093682 0.750190765573203 GO:0023023 MHC protein complex binding 5/1661 37/18639 0.135135135135135 1.51642611907513 0.230491584093682 0.750190765573203 GO:0043394 proteoglycan binding 5/1661 37/18639 0.135135135135135 1.51642611907513 0.230491584093682 0.750190765573203 GO:0005096 GTPase activator activity 28/1661 271/18639 0.103321033210332 1.15942247923382 0.231639689688835 0.750472408936419 GO:0008235 metalloexopeptidase activity 8/1661 66/18639 0.121212121212121 1.36018827650375 0.23228780042399 0.750472408936419 GO:0036408 histone H3K14 acetyltransferase activity 4/1661 28/18639 0.142857142857143 1.60307904016513 0.235965873045609 0.750472408936419 GO:0046625 sphingolipid binding 4/1661 28/18639 0.142857142857143 1.60307904016513 0.235965873045609 0.750472408936419 GO:0097718 disordered domain specific binding 4/1661 28/18639 0.142857142857143 1.60307904016513 0.235965873045609 0.750472408936419 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/1661 19/18639 0.157894736842105 1.77182420228778 0.236826846783433 0.750472408936419 GO:0008301 DNA binding, bending 3/1661 19/18639 0.157894736842105 1.77182420228778 0.236826846783433 0.750472408936419 GO:0042577 lipid phosphatase activity 3/1661 19/18639 0.157894736842105 1.77182420228778 0.236826846783433 0.750472408936419 GO:0050145 nucleoside monophosphate kinase activity 3/1661 19/18639 0.157894736842105 1.77182420228778 0.236826846783433 0.750472408936419 GO:0070003 threonine-type peptidase activity 3/1661 19/18639 0.157894736842105 1.77182420228778 0.236826846783433 0.750472408936419 GO:0005504 fatty acid binding 6/1661 47/18639 0.127659574468085 1.43253871674331 0.238322510787841 0.753224566989991 GO:0016504 peptidase activator activity 7/1661 57/18639 0.12280701754386 1.37808549066827 0.242656796265446 0.760749669313947 GO:0019888 protein phosphatase regulator activity 12/1661 107/18639 0.11214953271028 1.25849195676515 0.243720065399709 0.760749669313947 GO:0003724 RNA helicase activity 9/1661 77/18639 0.116883116883117 1.31161012377147 0.245715952832938 0.760749669313947 GO:0035091 phosphatidylinositol binding 29/1661 284/18639 0.102112676056338 1.14586283504761 0.24658850145536 0.760749669313947 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/1661 38/18639 0.131578947368421 1.47652016857315 0.247558056695942 0.760749669313947 GO:0010484 histone H3 acetyltransferase activity 4/1661 29/18639 0.137931034482759 1.54780045257323 0.25600815748392 0.760749669313947 GO:0106222 lncRNA binding 4/1661 29/18639 0.137931034482759 1.54780045257323 0.25600815748392 0.760749669313947 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0001851 complement component C3b binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0002162 dystroglycan binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0003953 NAD+ nucleosidase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0005114 type II transforming growth factor beta receptor binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0035252 UDP-xylosyltransferase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0042285 xylosyltransferase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0043522 leucine zipper domain binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0050786 RAGE receptor binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0070697 activin receptor binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0070990 snRNP binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:1900750 oligopeptide binding 2/1661 11/18639 0.181818181818182 2.04028241475562 0.256346499151043 0.760749669313947 GO:0061980 regulatory RNA binding 7/1661 58/18639 0.120689655172414 1.35432539600158 0.256539230701206 0.760749669313947 GO:0000339 RNA cap binding 3/1661 20/18639 0.15 1.68323299217339 0.261594660100976 0.768154490907756 GO:0010851 cyclase regulator activity 3/1661 20/18639 0.15 1.68323299217339 0.261594660100976 0.768154490907756 GO:0016505 peptidase activator activity involved in apoptotic process 3/1661 20/18639 0.15 1.68323299217339 0.261594660100976 0.768154490907756 GO:0061608 nuclear import signal receptor activity 3/1661 20/18639 0.15 1.68323299217339 0.261594660100976 0.768154490907756 GO:0060589 nucleoside-triphosphatase regulator activity 48/1661 490/18639 0.0979591836734694 1.09925419897038 0.264680271238759 0.775319526238414 GO:0016763 pentosyltransferase activity 6/1661 49/18639 0.122448979591837 1.37406774871297 0.269083279234994 0.783316753266862 GO:0008186 ATP-dependent activity, acting on RNA 9/1661 79/18639 0.113924050632911 1.27840480418232 0.269730202836241 0.783316753266862 GO:0015459 potassium channel regulator activity 7/1661 59/18639 0.11864406779661 1.33137072827274 0.270645143405932 0.783316753266862 GO:0036002 pre-mRNA binding 7/1661 59/18639 0.11864406779661 1.33137072827274 0.270645143405932 0.783316753266862 GO:0008080 N-acetyltransferase activity 8/1661 69/18639 0.115942028985507 1.30104965578619 0.2706714842679 0.783316753266862 GO:0015215 nucleotide transmembrane transporter activity 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0016769 transferase activity, transferring nitrogenous groups 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0043995 histone H4K5 acetyltransferase activity 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0043996 histone H4K8 acetyltransferase activity 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0043997 histone H4K12 acetyltransferase activity 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0070566 adenylyltransferase activity 4/1661 30/18639 0.133333333333333 1.49620710415412 0.276372578172545 0.788416784763008 GO:0005244 voltage-gated monoatomic ion channel activity 18/1661 173/18639 0.104046242774566 1.16756045699888 0.279874023624586 0.796513512732532 GO:0004540 RNA nuclease activity 13/1661 121/18639 0.107438016528926 1.20562142690105 0.281021000448133 0.797119457344715 GO:0004177 aminopeptidase activity 5/1661 40/18639 0.125 1.40269416014449 0.282572373989099 0.797119457344715 GO:0020037 heme binding 15/1661 142/18639 0.105633802816901 1.18537534660098 0.283106832151448 0.797119457344715 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1661 21/18639 0.142857142857143 1.60307904016513 0.286663847590389 0.797119457344715 GO:0070182 DNA polymerase binding 3/1661 21/18639 0.142857142857143 1.60307904016513 0.286663847590389 0.797119457344715 GO:0004300 enoyl-CoA hydratase activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0005095 GTPase inhibitor activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0010853 cyclase activator activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0016801 hydrolase activity, acting on ether bonds 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0016803 ether hydrolase activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0034452 dynactin binding 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0035259 nuclear glucocorticoid receptor binding 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0043047 single-stranded telomeric DNA binding 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/1661 12/18639 0.166666666666667 1.87025888019265 0.290706346641953 0.797119457344715 GO:0022832 voltage-gated channel activity 18/1661 175/18639 0.102857142857143 1.1542169089189 0.296580150835288 0.806233489140246 GO:0005164 tumor necrosis factor receptor binding 4/1661 31/18639 0.129032258064516 1.44794235885883 0.296984925812789 0.806233489140246 GO:0016411 acylglycerol O-acyltransferase activity 4/1661 31/18639 0.129032258064516 1.44794235885883 0.296984925812789 0.806233489140246 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1661 31/18639 0.129032258064516 1.44794235885883 0.296984925812789 0.806233489140246 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/1661 61/18639 0.114754098360656 1.28771922898511 0.299429455043396 0.806233489140246 GO:0001530 lipopolysaccharide binding 5/1661 41/18639 0.121951219512195 1.36848210745804 0.300425385955181 0.806233489140246 GO:0001727 lipid kinase activity 5/1661 41/18639 0.121951219512195 1.36848210745804 0.300425385955181 0.806233489140246 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/1661 41/18639 0.121951219512195 1.36848210745804 0.300425385955181 0.806233489140246 GO:0017080 sodium channel regulator activity 5/1661 41/18639 0.121951219512195 1.36848210745804 0.300425385955181 0.806233489140246 GO:0005048 signal sequence binding 6/1661 51/18639 0.117647058823529 1.32018273895952 0.300743216598526 0.806233489140246 GO:0019955 cytokine binding 15/1661 144/18639 0.104166666666667 1.16891180012041 0.301685281103858 0.806957734088492 GO:0043178 alcohol binding 10/1661 92/18639 0.108695652173913 1.21973405229956 0.303047347551893 0.808799698688497 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 23/1661 229/18639 0.100436681222707 1.12705556972308 0.304322244027529 0.810401363807234 GO:0004722 protein serine/threonine phosphatase activity 11/1661 103/18639 0.106796116504854 1.19841831157976 0.310263199324562 0.821485041043203 GO:0008093 cytoskeletal anchor activity 3/1661 22/18639 0.136363636363636 1.53021181106672 0.311904395267028 0.821485041043203 GO:0008970 phospholipase A1 activity 3/1661 22/18639 0.136363636363636 1.53021181106672 0.311904395267028 0.821485041043203 GO:0070034 telomerase RNA binding 3/1661 22/18639 0.136363636363636 1.53021181106672 0.311904395267028 0.821485041043203 GO:0140517 protein-RNA adaptor activity 3/1661 22/18639 0.136363636363636 1.53021181106672 0.311904395267028 0.821485041043203 GO:0030695 GTPase regulator activity 47/1661 489/18639 0.0961145194274029 1.0785542008473 0.313364977132393 0.823525902704603 GO:0051059 NF-kappaB binding 4/1661 32/18639 0.125 1.40269416014449 0.317773597832394 0.826036212045792 GO:0070717 poly-purine tract binding 4/1661 32/18639 0.125 1.40269416014449 0.317773597832394 0.826036212045792 GO:0071813 lipoprotein particle binding 4/1661 32/18639 0.125 1.40269416014449 0.317773597832394 0.826036212045792 GO:0071814 protein-lipid complex binding 4/1661 32/18639 0.125 1.40269416014449 0.317773597832394 0.826036212045792 GO:0008307 structural constituent of muscle 5/1661 42/18639 0.119047619047619 1.33589920013761 0.318446932703748 0.826036212045792 GO:0043175 RNA polymerase core enzyme binding 5/1661 42/18639 0.119047619047619 1.33589920013761 0.318446932703748 0.826036212045792 GO:0005542 folic acid binding 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0008253 5'-nucleotidase activity 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0017154 semaphorin receptor activity 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0031432 titin binding 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0071837 HMG box domain binding 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0140333 glycerophospholipid flippase activity 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0140852 histone ubiquitin ligase activity 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:1901338 catecholamine binding 2/1661 13/18639 0.153846153846154 1.72639281248553 0.32485137905682 0.82822804221316 GO:0061659 ubiquitin-like protein ligase activity 36/1661 372/18639 0.0967741935483871 1.08595676914412 0.325841462962566 0.82822804221316 GO:0002020 protease binding 14/1661 136/18639 0.102941176470588 1.15515989658958 0.326188063252976 0.82822804221316 GO:0004864 protein phosphatase inhibitor activity 6/1661 53/18639 0.113207547169811 1.27036452239501 0.333039440137667 0.842063931800712 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/1661 53/18639 0.113207547169811 1.27036452239501 0.333039440137667 0.842063931800712 GO:0008200 ion channel inhibitor activity 5/1661 43/18639 0.116279069767442 1.3048317768786 0.336591804663336 0.847223407348995 GO:0005158 insulin receptor binding 3/1661 23/18639 0.130434782608696 1.46368086275947 0.337196326988193 0.847223407348995 GO:0005212 structural constituent of eye lens 3/1661 23/18639 0.130434782608696 1.46368086275947 0.337196326988193 0.847223407348995 GO:0061630 ubiquitin protein ligase activity 34/1661 353/18639 0.0963172804532578 1.08082949450227 0.3422639986473 0.858160881785819 GO:0008013 beta-catenin binding 11/1661 106/18639 0.10377358490566 1.16450081219543 0.344437237462459 0.860339510660757 GO:0140463 chromatin-protein adaptor activity 6/1661 54/18639 0.111111111111111 1.24683925346177 0.349345609290982 0.860339510660757 GO:0016407 acetyltransferase activity 10/1661 96/18639 0.104166666666667 1.16891180012041 0.351118783726117 0.860339510660757 GO:0019205 nucleobase-containing compound kinase activity 5/1661 44/18639 0.113636363636364 1.27517650922226 0.354816136933308 0.860339510660757 GO:0005543 phospholipid binding 47/1661 497/18639 0.0945674044265594 1.06119316743326 0.355420666576186 0.860339510660757 GO:0140767 enzyme-substrate adaptor activity 14/1661 139/18639 0.100719424460432 1.13022838803009 0.356327778825632 0.860339510660757 GO:0005344 oxygen carrier activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0005347 ATP transmembrane transporter activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0005545 1-phosphatidylinositol binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0008195 phosphatidate phosphatase activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0008331 high voltage-gated calcium channel activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0008559 ABC-type xenobiotic transporter activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0016530 metallochaperone activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0019992 diacylglycerol binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0032036 myosin heavy chain binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0034236 protein kinase A catalytic subunit binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0044548 S100 protein binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0061665 SUMO ligase activity 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0098847 sequence-specific single stranded DNA binding 2/1661 14/18639 0.142857142857143 1.60307904016513 0.358547126689071 0.860339510660757 GO:0042393 histone binding 24/1661 247/18639 0.097165991902834 1.09035335525402 0.358983968525258 0.860339510660757 GO:0008376 acetylgalactosaminyltransferase activity 4/1661 34/18639 0.117647058823529 1.32018273895952 0.359609021108826 0.860339510660757 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1661 34/18639 0.117647058823529 1.32018273895952 0.359609021108826 0.860339510660757 GO:0035591 signaling adaptor activity 13/1661 129/18639 0.10077519379845 1.13085420662812 0.363515359203874 0.866924597847688 GO:0061134 peptidase regulator activity 22/1661 226/18639 0.0973451327433628 1.09236359374084 0.364091612967755 0.866924597847688 GO:0004674 protein serine/threonine kinase activity 41/1661 433/18639 0.0946882217090069 1.06254892500553 0.364526995764432 0.866924597847688 GO:0017022 myosin binding 8/1661 76/18639 0.105263157894737 1.18121613485852 0.365632894734082 0.867836179003226 GO:0140996 histone H3 kinase activity 34/1661 357/18639 0.0952380952380952 1.06871936011009 0.367532739388571 0.870624891529928 GO:0008081 phosphoric diester hydrolase activity 9/1661 87/18639 0.103448275862069 1.16085033942992 0.371150230160543 0.877463437840182 GO:0008009 chemokine activity 5/1661 45/18639 0.111111111111111 1.24683925346177 0.373077613714871 0.880287257507976 GO:0008237 metallopeptidase activity 18/1661 184/18639 0.0978260869565217 1.0977606470696 0.374971403425201 0.882391527828614 GO:0008170 N-methyltransferase activity 10/1661 98/18639 0.102040816326531 1.14505645726081 0.375585270655111 0.882391527828614 GO:0046906 tetrapyrrole binding 15/1661 152/18639 0.0986842105263158 1.10739012642986 0.378887435333157 0.882391527828614 GO:0000175 3'-5'-RNA exonuclease activity 4/1661 35/18639 0.114285714285714 1.28246323213211 0.38052902809479 0.882391527828614 GO:0010485 histone H4 acetyltransferase activity 4/1661 35/18639 0.114285714285714 1.28246323213211 0.38052902809479 0.882391527828614 GO:0140566 histone reader activity 4/1661 35/18639 0.114285714285714 1.28246323213211 0.38052902809479 0.882391527828614 GO:1901981 phosphatidylinositol phosphate binding 18/1661 185/18639 0.0972972972972973 1.09182680573409 0.383911039690279 0.882391527828614 GO:0035173 histone kinase activity 34/1661 360/18639 0.0944444444444444 1.0598133654425 0.386743546335837 0.882391527828614 GO:0003707 nuclear steroid receptor activity 3/1661 25/18639 0.12 1.34658639373871 0.3875056191013 0.882391527828614 GO:0008483 transaminase activity 3/1661 25/18639 0.12 1.34658639373871 0.3875056191013 0.882391527828614 GO:0016500 protein-hormone receptor activity 7/1661 67/18639 0.104477611940299 1.17240108907599 0.388605031391039 0.882391527828614 GO:0004129 cytochrome-c oxidase activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0004559 alpha-mannosidase activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0004953 icosanoid receptor activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0008252 nucleotidase activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0030553 cGMP binding 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0045504 dynein heavy chain binding 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0050700 CARD domain binding 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0050780 dopamine receptor binding 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0120283 protein serine/threonine kinase binding 2/1661 15/18639 0.133333333333333 1.49620710415412 0.391602568137095 0.882391527828614 GO:0106310 protein serine kinase activity 34/1661 361/18639 0.0941828254847645 1.0568775943471 0.393187112539559 0.884302850486911 GO:0043130 ubiquitin binding 10/1661 100/18639 0.1 1.12215532811559 0.400202595414695 0.897668828454307 GO:0004190 aspartic-type endopeptidase activity 4/1661 36/18639 0.111111111111111 1.24683925346177 0.401372323796805 0.897668828454307 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1661 36/18639 0.111111111111111 1.24683925346177 0.401372323796805 0.897668828454307 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 12/1661 122/18639 0.0983606557377049 1.10375933913009 0.404541777106259 0.903075602796687 GO:0033293 monocarboxylic acid binding 8/1661 79/18639 0.10126582278481 1.13635982593984 0.407410409301466 0.905325758573632 GO:0140359 ABC-type transporter activity 5/1661 47/18639 0.106382978723404 1.19378226395276 0.40955148995918 0.905325758573632 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0008143 poly(A) binding 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0008198 ferrous iron binding 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0015216 purine nucleotide transmembrane transporter activity 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0030507 spectrin binding 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0034237 protein kinase A regulatory subunit binding 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0120014 phospholipid transfer activity 3/1661 26/18639 0.115384615384615 1.29479460936415 0.412334046577666 0.905325758573632 GO:0002039 p53 binding 7/1661 69/18639 0.101449275362319 1.13841844881292 0.418641603890767 0.905802440443186 GO:0141003 histone H2AX kinase activity 33/1661 354/18639 0.0932203389830508 1.04607700078572 0.419345513350195 0.905802440443186 GO:0016829 lyase activity 19/1661 200/18639 0.095 1.06604756170981 0.420176658869919 0.905802440443186 GO:0070001 aspartic-type peptidase activity 4/1661 37/18639 0.108108108108108 1.2131408952601 0.422085140730517 0.905802440443186 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0005149 interleukin-1 receptor binding 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0005521 lamin binding 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0015923 mannosidase activity 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0019841 retinol binding 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0140327 flippase activity 2/1661 16/18639 0.125 1.40269416014449 0.423864256060841 0.905802440443186 GO:0005267 potassium channel activity 12/1661 124/18639 0.0967741935483871 1.08595676914412 0.42690457175735 0.91067920191932 GO:0005125 cytokine activity 22/1661 234/18639 0.094017094017094 1.05501782985227 0.428735917775299 0.912964250439955 GO:0030971 receptor tyrosine kinase binding 8/1661 81/18639 0.0987654320987654 1.10830155863268 0.435257154814404 0.917057076235876 GO:0004364 glutathione transferase activity 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0005104 fibroblast growth factor receptor binding 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0008395 steroid hydroxylase activity 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0035255 ionotropic glutamate receptor binding 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1661 27/18639 0.111111111111111 1.24683925346177 0.436835550196119 0.917057076235876 GO:0016779 nucleotidyltransferase activity 13/1661 136/18639 0.0955882352941176 1.07264847540461 0.438286409949016 0.917057076235876 GO:0140789 histone phosphatase activity 13/1661 136/18639 0.0955882352941176 1.07264847540461 0.438286409949016 0.917057076235876 GO:0030414 peptidase inhibitor activity 16/1661 169/18639 0.0946745562130177 1.06239557691417 0.438293723363358 0.917057076235876 GO:0005501 retinoid binding 4/1661 38/18639 0.105263157894737 1.18121613485852 0.442617738852231 0.921289262325008 GO:0019840 isoprenoid binding 4/1661 38/18639 0.105263157894737 1.18121613485852 0.442617738852231 0.921289262325008 GO:0043531 ADP binding 4/1661 38/18639 0.105263157894737 1.18121613485852 0.442617738852231 0.921289262325008 GO:0035254 glutamate receptor binding 5/1661 49/18639 0.102040816326531 1.14505645726081 0.445711720882651 0.926124181280387 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0004550 nucleoside diphosphate kinase activity 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0008429 phosphatidylethanolamine binding 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0015278 intracellularly gated calcium channel activity 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0016018 cyclosporin A binding 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0016805 dipeptidase activity 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0045236 CXCR chemokine receptor binding 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0070492 oligosaccharide binding 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:1990226 histone methyltransferase binding 2/1661 17/18639 0.117647058823529 1.32018273895952 0.455211143898514 0.92819793518186 GO:0019789 SUMO transferase activity 3/1661 28/18639 0.107142857142857 1.20230928012385 0.46093991145418 0.937442993626874 GO:0000217 DNA secondary structure binding 4/1661 39/18639 0.102564102564103 1.15092854165702 0.462924427460101 0.937442993626874 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1661 39/18639 0.102564102564103 1.15092854165702 0.462924427460101 0.937442993626874 GO:0015605 organophosphate ester transmembrane transporter activity 5/1661 50/18639 0.1 1.12215532811559 0.463588871267335 0.937442993626874 GO:0016836 hydro-lyase activity 6/1661 61/18639 0.0983606557377049 1.10375933913009 0.463647908588146 0.937442993626874 GO:0016755 aminoacyltransferase activity 45/1661 496/18639 0.0907258064516129 1.01808447107261 0.472688152927531 0.954115078430192 GO:0004527 exonuclease activity 8/1661 84/18639 0.0952380952380952 1.06871936011009 0.476686066307803 0.954411771658103 GO:0004521 RNA endonuclease activity 7/1661 73/18639 0.0958904109589041 1.07603935572728 0.478141370920021 0.954411771658103 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1661 40/18639 0.1 1.12215532811559 0.482963544512435 0.954411771658103 GO:0061791 GTPase motor activity 4/1661 40/18639 0.1 1.12215532811559 0.482963544512435 0.954411771658103 GO:1990606 membrane scission GTPase motor activity 4/1661 40/18639 0.1 1.12215532811559 0.482963544512435 0.954411771658103 GO:0015078 proton transmembrane transporter activity 17/1661 185/18639 0.0918918918918919 1.03116976097109 0.484575004148551 0.954411771658103 GO:0003785 actin monomer binding 3/1661 29/18639 0.103448275862069 1.16085033942992 0.484585883066133 0.954411771658103 GO:0004181 metallocarboxypeptidase activity 3/1661 29/18639 0.103448275862069 1.16085033942992 0.484585883066133 0.954411771658103 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1661 29/18639 0.103448275862069 1.16085033942992 0.484585883066133 0.954411771658103 GO:0097472 cyclin-dependent protein kinase activity 3/1661 29/18639 0.103448275862069 1.16085033942992 0.484585883066133 0.954411771658103 GO:0000400 four-way junction DNA binding 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:0003746 translation elongation factor activity 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:0017075 syntaxin-1 binding 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:1990381 ubiquitin-specific protease binding 2/1661 18/18639 0.111111111111111 1.24683925346177 0.485550035373107 0.954411771658103 GO:0005085 guanyl-nucleotide exchange factor activity 21/1661 230/18639 0.091304347826087 1.02457660393163 0.487168389598629 0.956028163248291 GO:0004721 phosphoprotein phosphatase activity 16/1661 175/18639 0.0914285714285714 1.02597058570569 0.495683154034031 0.964150415380891 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/1661 52/18639 0.0961538461538462 1.07899550780345 0.498785384837421 0.964150415380891 GO:0004518 nuclease activity 19/1661 209/18639 0.0909090909090909 1.02014120737781 0.499025206283886 0.964150415380891 GO:0008227 G protein-coupled amine receptor activity 4/1661 41/18639 0.0975609756097561 1.09478568596643 0.502697399491597 0.964150415380891 GO:0019787 ubiquitin-like protein transferase activity 43/1661 479/18639 0.0897703549060543 1.00736282064657 0.503590194410003 0.964150415380891 GO:0016209 antioxidant activity 8/1661 86/18639 0.0930232558139535 1.04386542150288 0.503899589224829 0.964150415380891 GO:0001968 fibronectin binding 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0022839 monoatomic ion-gated channel activity 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0031210 phosphatidylcholine binding 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0031624 ubiquitin conjugating enzyme binding 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0051721 protein phosphatase 2A binding 3/1661 30/18639 0.1 1.12215532811559 0.507720694720976 0.964150415380891 GO:0005506 iron ion binding 14/1661 154/18639 0.0909090909090909 1.02014120737781 0.509936413571516 0.964150415380891 GO:0140597 protein carrier chaperone 17/1661 188/18639 0.0904255319148936 1.01471492435984 0.512149139691878 0.964150415380891 GO:0005249 voltage-gated potassium channel activity 9/1661 98/18639 0.0918367346938776 1.03055081153473 0.51358883338361 0.964150415380891 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0008574 plus-end-directed microtubule motor activity 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0016918 retinal binding 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0042800 histone H3K4 methyltransferase activity 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0043395 heparan sulfate proteoglycan binding 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0141147 intracellularly calcium-gated channel activity 2/1661 19/18639 0.105263157894737 1.18121613485852 0.514811586971892 0.964150415380891 GO:0017046 peptide hormone binding 5/1661 53/18639 0.0943396226415094 1.05863710199584 0.516050587410311 0.964150415380891 GO:0034212 protein N-acetyltransferase activity 5/1661 53/18639 0.0943396226415094 1.05863710199584 0.516050587410311 0.964150415380891 GO:0004402 histone acetyltransferase activity 4/1661 42/18639 0.0952380952380952 1.06871936011009 0.522092185469266 0.964150415380891 GO:0005319 lipid transporter activity 16/1661 178/18639 0.0898876404494382 1.00867894662076 0.523974464506251 0.964150415380891 GO:0004842 ubiquitin-protein transferase activity 40/1661 449/18639 0.089086859688196 0.999692942641954 0.52554231742113 0.964150415380891 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 15/1661 167/18639 0.0898203592814371 1.00792394740922 0.526878101132987 0.964150415380891 GO:0016878 acid-thiol ligase activity 3/1661 31/18639 0.0967741935483871 1.08595676914412 0.530299527103997 0.964150415380891 GO:0047499 calcium-independent phospholipase A2 activity 3/1661 31/18639 0.0967741935483871 1.08595676914412 0.530299527103997 0.964150415380891 GO:0015485 cholesterol binding 5/1661 54/18639 0.0925925925925926 1.03903271121814 0.533061299463304 0.964150415380891 GO:1902936 phosphatidylinositol bisphosphate binding 10/1661 111/18639 0.0900900900900901 1.01095074605008 0.534052219355429 0.964150415380891 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/1661 43/18639 0.0930232558139535 1.04386542150288 0.541117865551925 0.964150415380891 GO:0005245 voltage-gated calcium channel activity 4/1661 43/18639 0.0930232558139535 1.04386542150288 0.541117865551925 0.964150415380891 GO:0001614 purinergic nucleotide receptor activity 2/1661 20/18639 0.1 1.12215532811559 0.54294680106866 0.964150415380891 GO:0001972 retinoic acid binding 2/1661 20/18639 0.1 1.12215532811559 0.54294680106866 0.964150415380891 GO:0016502 nucleotide receptor activity 2/1661 20/18639 0.1 1.12215532811559 0.54294680106866 0.964150415380891 GO:0030742 GTP-dependent protein binding 2/1661 20/18639 0.1 1.12215532811559 0.54294680106866 0.964150415380891 GO:0005200 structural constituent of cytoskeleton 10/1661 112/18639 0.0892857142857143 1.00192440010321 0.545791822365013 0.964150415380891 GO:0008374 O-acyltransferase activity 5/1661 55/18639 0.0909090909090909 1.02014120737781 0.54979588605963 0.964150415380891 GO:0140313 molecular sequestering activity 5/1661 55/18639 0.0909090909090909 1.02014120737781 0.54979588605963 0.964150415380891 GO:0008378 galactosyltransferase activity 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0022884 macromolecule transmembrane transporter activity 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0031369 translation initiation factor binding 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0042910 xenobiotic transmembrane transporter activity 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0047498 calcium-dependent phospholipase A2 activity 3/1661 32/18639 0.09375 1.05202062010837 0.552284968063128 0.964150415380891 GO:0042054 histone methyltransferase activity 6/1661 67/18639 0.0895522388059701 1.00491521920799 0.557213105795603 0.964150415380891 GO:0030547 signaling receptor inhibitor activity 4/1661 44/18639 0.0909090909090909 1.02014120737781 0.559748038413787 0.964150415380891 GO:0043014 alpha-tubulin binding 4/1661 44/18639 0.0909090909090909 1.02014120737781 0.559748038413787 0.964150415380891 GO:0030170 pyridoxal phosphate binding 5/1661 56/18639 0.0892857142857143 1.00192440010321 0.566234831541558 0.964150415380891 GO:0003689 DNA clamp loader activity 14/1661 160/18639 0.0875 0.981885912101144 0.569356242421848 0.964150415380891 GO:0005248 voltage-gated sodium channel activity 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:0019200 carbohydrate kinase activity 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:0036122 BMP binding 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:0061891 calcium ion sensor activity 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:1904047 S-adenosyl-L-methionine binding 2/1661 21/18639 0.0952380952380952 1.06871936011009 0.569923954066373 0.964150415380891 GO:0032934 sterol binding 6/1661 68/18639 0.0882352941176471 0.990137054219641 0.572075973213267 0.964150415380891 GO:0019239 deaminase activity 3/1661 33/18639 0.0909090909090909 1.02014120737781 0.573646462199962 0.964150415380891 GO:0140311 protein sequestering activity 3/1661 33/18639 0.0909090909090909 1.02014120737781 0.573646462199962 0.964150415380891 GO:0042605 peptide antigen binding 4/1661 45/18639 0.0888888888888889 0.997471402769416 0.577959787164901 0.964150415380891 GO:0004866 endopeptidase inhibitor activity 14/1661 161/18639 0.0869565217391304 0.975787241839646 0.578996781282719 0.964150415380891 GO:0061135 endopeptidase regulator activity 16/1661 184/18639 0.0869565217391304 0.975787241839646 0.579101385889257 0.964150415380891 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1661 57/18639 0.087719298245614 0.984346779048766 0.582360688600393 0.964150415380891 GO:0070279 vitamin B6 binding 5/1661 57/18639 0.087719298245614 0.984346779048766 0.582360688600393 0.964150415380891 GO:0016279 protein-lysine N-methyltransferase activity 6/1661 69/18639 0.0869565217391304 0.975787241839646 0.586688770291599 0.964150415380891 GO:0045296 cadherin binding 29/1661 334/18639 0.0868263473053892 0.974326482495575 0.587302738875448 0.964150415380891 GO:0001618 virus receptor activity 7/1661 81/18639 0.0864197530864197 0.969763863803599 0.590890971750865 0.964150415380891 GO:0000510 H3-H4 histone complex chaperone activity 13/1661 151/18639 0.0860927152317881 0.966093991092895 0.593910030099157 0.964150415380891 GO:0140584 chromatin extrusion motor activity 13/1661 151/18639 0.0860927152317881 0.966093991092895 0.593910030099157 0.964150415380891 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 13/1661 151/18639 0.0860927152317881 0.966093991092895 0.593910030099157 0.964150415380891 GO:0140849 ATP-dependent H2AZ histone chaperone activity 13/1661 151/18639 0.0860927152317881 0.966093991092895 0.593910030099157 0.964150415380891 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/1661 34/18639 0.0882352941176471 0.990137054219641 0.594359762950717 0.964150415380891 GO:0019825 oxygen binding 3/1661 34/18639 0.0882352941176471 0.990137054219641 0.594359762950717 0.964150415380891 GO:0051427 hormone receptor binding 3/1661 34/18639 0.0882352941176471 0.990137054219641 0.594359762950717 0.964150415380891 GO:0005243 gap junction channel activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0032931 histone H3K56 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0034062 5'-3' RNA polymerase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0043992 histone H3K9 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0043993 histone H3K18 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0043994 histone H3K23 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0043999 histone H2AK5 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044012 histone H2AK9 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044014 histone H2BK5 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044015 histone H2BK12 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044016 histone H3K4 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044017 histone H3K27 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0044018 histone H3K36 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0046972 histone H4K16 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0061133 endopeptidase activator activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0097747 RNA polymerase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0140784 metal ion sensor activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0140908 histone H3K122 acetyltransferase activity 2/1661 22/18639 0.0909090909090909 1.02014120737781 0.595725909946307 0.964150415380891 GO:0051015 actin filament binding 18/1661 209/18639 0.0861244019138756 0.966449564884243 0.596315974798895 0.964150415380891 GO:0008408 3'-5' exonuclease activity 5/1661 58/18639 0.0862068965517241 0.96737528285827 0.59815801795436 0.964150415380891 GO:0016278 lysine N-methyltransferase activity 6/1661 70/18639 0.0857142857142857 0.96184742409908 0.601039122773779 0.964150415380891 GO:0097110 scaffold protein binding 6/1661 70/18639 0.0857142857142857 0.96184742409908 0.601039122773779 0.964150415380891 GO:1990782 protein tyrosine kinase binding 10/1661 117/18639 0.0854700854700855 0.959107118047515 0.602661741361291 0.964150415380891 GO:0015616 DNA translocase activity 13/1661 152/18639 0.0855263157894737 0.959738109572547 0.603660326095156 0.964150415380891 GO:0140674 ATP-dependent histone chaperone activity 13/1661 152/18639 0.0855263157894737 0.959738109572547 0.603660326095156 0.964150415380891 GO:0140272 exogenous protein binding 7/1661 82/18639 0.0853658536585366 0.957937475220628 0.604122166412975 0.964150415380891 GO:0001094 TFIID-class transcription factor complex binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0004382 GDP phosphatase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0004955 prostaglandin receptor activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0004983 neuropeptide Y receptor activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0008140 cAMP response element binding protein binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0008190 eukaryotic initiation factor 4E binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0008239 dipeptidyl-peptidase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0008519 ammonium channel activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0015203 polyamine transmembrane transporter activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0015643 toxic substance binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0016783 sulfurtransferase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0019911 structural constituent of myelin sheath 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0032395 MHC class II receptor activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0033204 ribonuclease P RNA binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0035256 G protein-coupled glutamate receptor binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0042166 acetylcholine binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0051378 serotonin binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0051880 G-quadruplex DNA binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0070097 delta-catenin binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0070739 protein-glutamic acid ligase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0070740 tubulin-glutamic acid ligase activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0097177 mitochondrial ribosome binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0099122 RNA polymerase II C-terminal domain binding 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0141109 transporter activator activity 1/1661 10/18639 0.1 1.12215532811559 0.606869631166741 0.964150415380891 GO:0140713 histone chaperone activity 14/1661 164/18639 0.0853658536585366 0.957937475220628 0.607373311068138 0.964150415380891 GO:0000149 SNARE binding 9/1661 106/18639 0.0849056603773585 0.952773391796258 0.610462097300734 0.964150415380891 GO:0061733 protein-lysine-acetyltransferase activity 4/1661 47/18639 0.0851063829787234 0.955025811162207 0.613052773537361 0.964150415380891 GO:0061775 cohesin loader activity 13/1661 153/18639 0.0849673202614379 0.953465311470765 0.613302683122119 0.964150415380891 GO:0004623 phospholipase A2 activity 3/1661 35/18639 0.0857142857142857 0.96184742409908 0.61440639434346 0.964150415380891 GO:0016229 steroid dehydrogenase activity 3/1661 35/18639 0.0857142857142857 0.96184742409908 0.61440639434346 0.964150415380891 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/1661 130/18639 0.0846153846153846 0.94951604686704 0.616741646386141 0.964150415380891 GO:0008276 protein methyltransferase activity 8/1661 95/18639 0.0842105263157895 0.944972907886815 0.619420642762877 0.964150415380891 GO:0000295 adenine nucleotide transmembrane transporter activity 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0008171 O-methyltransferase activity 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0017134 fibroblast growth factor binding 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0044013 histone H2B acetyltransferase activity 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0099186 structural constituent of postsynapse 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/1661 23/18639 0.0869565217391304 0.975787241839646 0.620347774989937 0.964150415380891 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1661 60/18639 0.0833333333333333 0.935129440096327 0.628714960698967 0.964150415380891 GO:0042379 chemokine receptor binding 6/1661 72/18639 0.0833333333333333 0.935129440096327 0.628909475564829 0.964150415380891 GO:0022843 voltage-gated monoatomic cation channel activity 12/1661 143/18639 0.0839160839160839 0.941668806810288 0.62963474863173 0.964150415380891 GO:0140098 catalytic activity, acting on RNA 33/1661 387/18639 0.0852713178294574 0.956876636377637 0.632073074149732 0.964150415380891 GO:0004386 helicase activity 13/1661 155/18639 0.0838709677419355 0.941162533258239 0.632247047934638 0.964150415380891 GO:0005496 steroid binding 9/1661 108/18639 0.0833333333333333 0.935129440096327 0.633117787671142 0.964150415380891 GO:0004033 aldo-keto reductase (NADPH) activity 3/1661 36/18639 0.0833333333333333 0.935129440096327 0.633773128029519 0.964150415380891 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0004954 prostanoid receptor activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0005225 volume-sensitive anion channel activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0005536 D-glucose binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0008046 axon guidance receptor activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0008172 S-methyltransferase activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0008199 ferric iron binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0008432 JUN kinase binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0015217 ADP transmembrane transporter activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0019206 nucleoside kinase activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0042608 T cell receptor binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0045294 alpha-catenin binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0048185 activin binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0140031 phosphorylation-dependent protein binding 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:1990948 ubiquitin ligase inhibitor activity 1/1661 11/18639 0.0909090909090909 1.02014120737781 0.641921944368311 0.964150415380891 GO:0019905 syntaxin binding 5/1661 61/18639 0.0819672131147541 0.919799449275076 0.643453090351719 0.964150415380891 GO:0004622 lysophospholipase activity 2/1661 24/18639 0.0833333333333333 0.935129440096327 0.643794854255894 0.964150415380891 GO:0043998 histone H2A acetyltransferase activity 2/1661 24/18639 0.0833333333333333 0.935129440096327 0.643794854255894 0.964150415380891 GO:0030551 cyclic nucleotide binding 3/1661 37/18639 0.0810810810810811 0.909855671445076 0.65245147985002 0.964150415380891 GO:0004725 protein tyrosine phosphatase activity 8/1661 98/18639 0.0816326530612245 0.916045165808647 0.654589569676508 0.964150415380891 GO:0042626 ATPase-coupled transmembrane transporter activity 8/1661 98/18639 0.0816326530612245 0.916045165808647 0.654589569676508 0.964150415380891 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/1661 86/18639 0.0813953488372093 0.913382243815018 0.654690084608154 0.964150415380891 GO:0004222 metalloendopeptidase activity 9/1661 110/18639 0.0818181818181818 0.918127086640031 0.655042115224373 0.964150415380891 GO:0035064 methylated histone binding 6/1661 74/18639 0.0810810810810811 0.909855671445076 0.655613433860007 0.964150415380891 GO:0140658 ATP-dependent chromatin remodeler activity 13/1661 158/18639 0.0822784810126582 0.923292358576121 0.659757175774048 0.964150415380891 GO:0000030 mannosyltransferase activity 2/1661 25/18639 0.08 0.897724262492475 0.66608087470412 0.964150415380891 GO:0005251 delayed rectifier potassium channel activity 2/1661 25/18639 0.08 0.897724262492475 0.66608087470412 0.964150415380891 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1661 25/18639 0.08 0.897724262492475 0.66608087470412 0.964150415380891 GO:0015645 fatty acid ligase activity 2/1661 25/18639 0.08 0.897724262492475 0.66608087470412 0.964150415380891 GO:0120515 fatty acid-CoA ligase activity 2/1661 25/18639 0.08 0.897724262492475 0.66608087470412 0.964150415380891 GO:0015085 calcium ion transmembrane transporter activity 12/1661 147/18639 0.0816326530612245 0.916045165808647 0.667578827244796 0.964150415380891 GO:0000340 RNA 7-methylguanosine cap binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0003720 telomerase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0004126 cytidine deaminase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0004526 ribonuclease P activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0004859 phospholipase inhibitor activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0005025 transforming growth factor beta receptor activity, type I 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0005026 transforming growth factor beta receptor activity, type II 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0005247 voltage-gated chloride channel activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0008179 adenylate cyclase binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0015269 calcium-activated potassium channel activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0016208 AMP binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0016361 activin receptor activity, type I 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0016362 activin receptor activity, type II 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0017002 activin receptor activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0031543 peptidyl-proline dioxygenase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0035197 siRNA binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0042301 phosphate ion binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0070008 serine-type exopeptidase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0097677 STAT family protein binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:1990459 transferrin receptor binding 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:1990817 poly(A) RNA polymerase activity 1/1661 12/18639 0.0833333333333333 0.935129440096327 0.673850635070707 0.964150415380891 GO:0015079 potassium ion transmembrane transporter activity 13/1661 160/18639 0.08125 0.911751204093919 0.677455464272595 0.964150415380891 GO:0016830 carbon-carbon lyase activity 4/1661 51/18639 0.0784313725490196 0.880121825973014 0.67755609384201 0.964150415380891 GO:0004197 cysteine-type endopeptidase activity 7/1661 88/18639 0.0795454545454545 0.892623556455585 0.67846529515063 0.964150415380891 GO:0140034 methylation-dependent protein binding 6/1661 76/18639 0.0789473684210526 0.885912101143889 0.681096352452536 0.964150415380891 GO:0004435 phosphatidylinositol phospholipase C activity 2/1661 26/18639 0.0769230769230769 0.863196406242764 0.687226443714657 0.964150415380891 GO:0005227 calcium-activated cation channel activity 2/1661 26/18639 0.0769230769230769 0.863196406242764 0.687226443714657 0.964150415380891 GO:0008157 protein phosphatase 1 binding 2/1661 26/18639 0.0769230769230769 0.863196406242764 0.687226443714657 0.964150415380891 GO:0043548 phosphatidylinositol 3-kinase binding 2/1661 26/18639 0.0769230769230769 0.863196406242764 0.687226443714657 0.964150415380891 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/1661 89/18639 0.0786516853932584 0.882594078293163 0.689957908205672 0.964150415380891 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/1661 89/18639 0.0786516853932584 0.882594078293163 0.689957908205672 0.964150415380891 GO:0030159 signaling receptor complex adaptor activity 4/1661 52/18639 0.0769230769230769 0.863196406242764 0.692453652925726 0.964150415380891 GO:0140793 histone H2AXY142 phosphatase activity 7/1661 90/18639 0.0777777777777778 0.872787477423239 0.701182503357713 0.964150415380891 GO:0003964 RNA-directed DNA polymerase activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0004465 lipoprotein lipase activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0004535 poly(A)-specific ribonuclease activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0004993 G protein-coupled serotonin receptor activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0005172 vascular endothelial growth factor receptor binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0008035 high-density lipoprotein particle binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0019855 calcium channel inhibitor activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0030955 potassium ion binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0035325 Toll-like receptor binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0035673 oligopeptide transmembrane transporter activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0045159 myosin II binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0046975 histone H3K36 methyltransferase activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0061459 L-arginine transmembrane transporter activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0070123 transforming growth factor beta receptor activity, type III 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0089720 caspase binding 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0140666 annealing activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1661 13/18639 0.0769230769230769 0.863196406242764 0.702933906405197 0.964150415380891 GO:0030331 nuclear estrogen receptor binding 3/1661 40/18639 0.075 0.841616496086695 0.704332645089903 0.964150415380891 GO:0050997 quaternary ammonium group binding 3/1661 40/18639 0.075 0.841616496086695 0.704332645089903 0.964150415380891 GO:0071949 FAD binding 3/1661 40/18639 0.075 0.841616496086695 0.704332645089903 0.964150415380891 GO:0004519 endonuclease activity 10/1661 127/18639 0.078740157480315 0.883586872531963 0.704830586911679 0.964150415380891 GO:0051018 protein kinase A binding 4/1661 53/18639 0.0754716981132075 0.846909681596674 0.706853903171882 0.964150415380891 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1661 53/18639 0.0754716981132075 0.846909681596674 0.706853903171882 0.964150415380891 GO:0008320 protein transmembrane transporter activity 2/1661 27/18639 0.0740740740740741 0.831226168974513 0.707257715196141 0.964150415380891 GO:0016405 CoA-ligase activity 2/1661 27/18639 0.0740740740740741 0.831226168974513 0.707257715196141 0.964150415380891 GO:0016835 carbon-oxygen lyase activity 6/1661 79/18639 0.0759493670886076 0.852269869454881 0.716954334445152 0.972297071898183 GO:0043177 organic acid binding 15/1661 189/18639 0.0793650793650794 0.890599466758407 0.718563477360472 0.972297071898183 GO:0140318 protein transporter activity 3/1661 41/18639 0.0731707317073171 0.821089264474824 0.720251217110823 0.972297071898183 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1661 54/18639 0.0740740740740741 0.831226168974513 0.720757311468568 0.972297071898183 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/1661 67/18639 0.0746268656716418 0.837429349339995 0.723899804878235 0.972297071898183 GO:0005242 inward rectifier potassium channel activity 2/1661 28/18639 0.0714285714285714 0.801539520082566 0.726205238560907 0.972297071898183 GO:0046875 ephrin receptor binding 2/1661 28/18639 0.0714285714285714 0.801539520082566 0.726205238560907 0.972297071898183 GO:0050698 proteoglycan sulfotransferase activity 2/1661 28/18639 0.0714285714285714 0.801539520082566 0.726205238560907 0.972297071898183 GO:0048306 calcium-dependent protein binding 6/1661 80/18639 0.075 0.841616496086695 0.728266215422922 0.972297071898183 GO:0005313 L-glutamate transmembrane transporter activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0008174 mRNA methyltransferase activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0031404 chloride ion binding 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0043176 amine binding 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0071933 Arp2/3 complex binding 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0098599 palmitoyl hydrolase activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0098821 BMP receptor activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:1901474 azole transmembrane transporter activity 1/1661 14/18639 0.0714285714285714 0.801539520082566 0.729425197152592 0.972297071898183 GO:0004175 endopeptidase activity 33/1661 405/18639 0.0814814814814815 0.914348785871965 0.732122398857208 0.974810422425174 GO:0003777 microtubule motor activity 5/1661 68/18639 0.0735294117647059 0.825114211849701 0.735949315327836 0.978820739433811 GO:0008017 microtubule binding 22/1661 276/18639 0.0797101449275362 0.894471638353009 0.739770258784155 0.982814248672312 GO:0005262 calcium channel activity 10/1661 131/18639 0.0763358778625954 0.856607120698926 0.740668180033042 0.982919872065949 GO:0004629 phospholipase C activity 2/1661 29/18639 0.0689655172413793 0.773900226286616 0.744102968597557 0.984215490402715 GO:0035250 UDP-galactosyltransferase activity 2/1661 29/18639 0.0689655172413793 0.773900226286616 0.744102968597557 0.984215490402715 GO:0099604 ligand-gated calcium channel activity 2/1661 29/18639 0.0689655172413793 0.773900226286616 0.744102968597557 0.984215490402715 GO:0008375 acetylglucosaminyltransferase activity 3/1661 43/18639 0.0697674418604651 0.782899066127158 0.750072446094253 0.984787831678166 GO:0005041 low-density lipoprotein particle receptor activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0008020 G protein-coupled photoreceptor activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0016846 carbon-sulfur lyase activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0031005 filamin binding 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0047372 monoacylglycerol lipase activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0061578 K63-linked deubiquitinase activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0141050 histone H3K deacetylase activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0141051 histone H4K deacetylase activity 1/1661 15/18639 0.0666666666666667 0.748103552077062 0.753555384939413 0.984787831678166 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1661 70/18639 0.0714285714285714 0.801539520082566 0.758885000996101 0.987822149118363 GO:0001540 amyloid-beta binding 6/1661 83/18639 0.072289156626506 0.811196622734164 0.760272703220855 0.987822149118363 GO:0030165 PDZ domain binding 6/1661 83/18639 0.072289156626506 0.811196622734164 0.760272703220855 0.987822149118363 GO:0001965 G-protein alpha-subunit binding 2/1661 30/18639 0.0666666666666667 0.748103552077062 0.760987416731598 0.987822149118363 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1661 30/18639 0.0666666666666667 0.748103552077062 0.760987416731598 0.987822149118363 GO:0098918 structural constituent of synapse 2/1661 30/18639 0.0666666666666667 0.748103552077062 0.760987416731598 0.987822149118363 GO:0016790 thiolester hydrolase activity 3/1661 44/18639 0.0681818181818182 0.765105905533359 0.763998622265994 0.987822149118363 GO:0017116 single-stranded DNA helicase activity 4/1661 58/18639 0.0689655172413793 0.773900226286616 0.771468198784528 0.987822149118363 GO:0005024 transforming growth factor beta receptor activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0015378 sodium:chloride symporter activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0015562 efflux transmembrane transporter activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0017070 U6 snRNA binding 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0022841 potassium ion leak channel activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0022858 alanine transmembrane transporter activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0055102 lipase inhibitor activity 1/1661 16/18639 0.0625 0.701347080072246 0.775534793531318 0.987822149118363 GO:0072349 modified amino acid transmembrane transporter activity 2/1661 31/18639 0.0645161290322581 0.723971179429415 0.776896926361088 0.987822149118363 GO:0046915 transition metal ion transmembrane transporter activity 3/1661 45/18639 0.0666666666666667 0.748103552077062 0.777287110487501 0.987822149118363 GO:0031267 small GTPase binding 22/1661 283/18639 0.0777385159010601 0.872346898181733 0.779707642167495 0.987822149118363 GO:0035403 histone H3T6 kinase activity 19/1661 247/18639 0.0769230769230769 0.863196406242764 0.78178326260672 0.987822149118363 GO:0050660 flavin adenine dinucleotide binding 6/1661 86/18639 0.0697674418604651 0.782899066127158 0.789414103266611 0.987822149118363 GO:0031406 carboxylic acid binding 14/1661 187/18639 0.0748663101604278 0.840116288428786 0.789597303220194 0.987822149118363 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1661 46/18639 0.0652173913043478 0.731840431379735 0.789953640380083 0.987822149118363 GO:0004549 tRNA-specific ribonuclease activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0004659 prenyltransferase activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0005092 GDP-dissociation inhibitor activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0008569 minus-end-directed microtubule motor activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0009881 photoreceptor activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0017110 nucleoside diphosphate phosphatase activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0019198 transmembrane receptor protein phosphatase activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0030169 low-density lipoprotein particle binding 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0031489 myosin V binding 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0032977 membrane insertase activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0038191 neuropilin binding 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0045125 bioactive lipid receptor activity 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0046965 nuclear retinoid X receptor binding 1/1661 17/18639 0.0588235294117647 0.660091369479761 0.795555021633368 0.987822149118363 GO:0048029 monosaccharide binding 5/1661 74/18639 0.0675675675675676 0.758213059537563 0.800196262757874 0.987822149118363 GO:0043495 protein-membrane adaptor activity 3/1661 47/18639 0.0638297872340425 0.716269358371655 0.80201506311936 0.987822149118363 GO:0099095 ligand-gated monoatomic anion channel activity 3/1661 47/18639 0.0638297872340425 0.716269358371655 0.80201506311936 0.987822149118363 GO:0140938 histone H3 methyltransferase activity 3/1661 47/18639 0.0638297872340425 0.716269358371655 0.80201506311936 0.987822149118363 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/1661 47/18639 0.0638297872340425 0.716269358371655 0.80201506311936 0.987822149118363 GO:0019956 chemokine binding 2/1661 33/18639 0.0606060606060606 0.680094138251875 0.805950063024886 0.987822149118363 GO:0030296 protein tyrosine kinase activator activity 2/1661 33/18639 0.0606060606060606 0.680094138251875 0.805950063024886 0.987822149118363 GO:0042923 neuropeptide binding 2/1661 33/18639 0.0606060606060606 0.680094138251875 0.805950063024886 0.987822149118363 GO:0019783 ubiquitin-like protein peptidase activity 9/1661 127/18639 0.0708661417322835 0.795228185278767 0.808397506441279 0.987822149118363 GO:0016741 transferase activity, transferring one-carbon groups 16/1661 215/18639 0.0744186046511628 0.835092337202302 0.809082069965951 0.987822149118363 GO:0003774 cytoskeletal motor activity 11/1661 153/18639 0.0718954248366013 0.806778340475263 0.812270161380421 0.987822149118363 GO:0038187 pattern recognition receptor activity 3/1661 48/18639 0.0625 0.701347080072246 0.813489128709512 0.987822149118363 GO:0043138 3'-5' DNA helicase activity 3/1661 48/18639 0.0625 0.701347080072246 0.813489128709512 0.987822149118363 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0008409 5'-3' exonuclease activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0015172 acidic amino acid transmembrane transporter activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0015373 monoatomic anion:sodium symporter activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0016854 racemase and epimerase activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0030228 lipoprotein particle receptor activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0035615 clathrin adaptor activity 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0050811 GABA receptor binding 1/1661 18/18639 0.0555555555555556 0.623419626730885 0.813790609060442 0.987822149118363 GO:0015179 L-amino acid transmembrane transporter activity 4/1661 62/18639 0.0645161290322581 0.723971179429415 0.814645283387958 0.987822149118363 GO:0001653 peptide receptor activity 9/1661 128/18639 0.0703125 0.789015465081276 0.815531304899251 0.987822149118363 GO:0008168 methyltransferase activity 15/1661 204/18639 0.0735294117647059 0.825114211849701 0.817071617228759 0.987822149118363 GO:0051020 GTPase binding 24/1661 315/18639 0.0761904761904762 0.854975488088071 0.818011723374499 0.987822149118363 GO:0015020 glucuronosyltransferase activity 2/1661 34/18639 0.0588235294117647 0.660091369479761 0.819174456779522 0.987822149118363 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1661 34/18639 0.0588235294117647 0.660091369479761 0.819174456779522 0.987822149118363 GO:0016831 carboxy-lyase activity 2/1661 34/18639 0.0588235294117647 0.660091369479761 0.819174456779522 0.987822149118363 GO:0090482 vitamin transmembrane transporter activity 2/1661 34/18639 0.0588235294117647 0.660091369479761 0.819174456779522 0.987822149118363 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 18/1661 243/18639 0.0740740740740741 0.831226168974513 0.826172853906701 0.987822149118363 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0022840 leak channel activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0022842 narrow pore channel activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0030506 ankyrin binding 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0031420 alkali metal ion binding 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0046624 sphingolipid transporter activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0099589 serotonin receptor activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:1990380 K48-linked deubiquitinase activity 1/1661 19/18639 0.0526315789473684 0.59060806742926 0.830400554732028 0.987822149118363 GO:0034061 DNA polymerase activity 2/1661 35/18639 0.0571428571428571 0.641231616066053 0.831584642381707 0.987822149118363 GO:0048020 CCR chemokine receptor binding 3/1661 50/18639 0.06 0.673293196869356 0.834749496665034 0.987822149118363 GO:0004676 3-phosphoinositide-dependent protein kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0004711 ribosomal protein S6 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0035175 histone H3S10 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0035979 histone H2AXS139 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0044022 histone H3S28 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0044023 histone H4S1 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0044024 histone H2AS1 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0044025 histone H2BS14 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0072354 histone H3T3 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0072371 histone H2AS121 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0072518 Rho-dependent protein serine/threonine kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0140823 histone H2BS36 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0140855 histone H3S57 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0140995 histone H2A kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0140997 histone H4 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0140998 histone H2B kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:1990244 histone H2AT120 kinase activity 18/1661 245/18639 0.073469387755102 0.824440649227783 0.835949058560195 0.987822149118363 GO:0052689 carboxylic ester hydrolase activity 6/1661 92/18639 0.0652173913043478 0.731840431379735 0.839452568162683 0.987822149118363 GO:0004677 DNA-dependent protein kinase activity 18/1661 246/18639 0.0731707317073171 0.821089264474824 0.84068140766254 0.987822149118363 GO:0140857 histone H3T45 kinase activity 18/1661 246/18639 0.0731707317073171 0.821089264474824 0.84068140766254 0.987822149118363 GO:0120013 lipid transfer activity 4/1661 65/18639 0.0615384615384615 0.690557124994211 0.842440036363831 0.987822149118363 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1661 36/18639 0.0555555555555556 0.623419626730885 0.843220613814189 0.987822149118363 GO:0005484 SNAP receptor activity 2/1661 36/18639 0.0555555555555556 0.623419626730885 0.843220613814189 0.987822149118363 GO:0016409 palmitoyltransferase activity 2/1661 36/18639 0.0555555555555556 0.623419626730885 0.843220613814189 0.987822149118363 GO:0016597 amino acid binding 3/1661 51/18639 0.0588235294117647 0.660091369479761 0.844574084341473 0.987822149118363 GO:0035402 histone H3T11 kinase activity 18/1661 247/18639 0.0728744939271255 0.817765016440513 0.845310956182211 0.987822149118363 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1661 20/18639 0.05 0.561077664057797 0.845529699661679 0.987822149118363 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/1661 20/18639 0.05 0.561077664057797 0.845529699661679 0.987822149118363 GO:0015095 magnesium ion transmembrane transporter activity 1/1661 20/18639 0.05 0.561077664057797 0.845529699661679 0.987822149118363 GO:0030627 pre-mRNA 5'-splice site binding 1/1661 20/18639 0.05 0.561077664057797 0.845529699661679 0.987822149118363 GO:0031418 L-ascorbic acid binding 1/1661 20/18639 0.05 0.561077664057797 0.845529699661679 0.987822149118363 GO:0008094 ATP-dependent activity, acting on DNA 15/1661 210/18639 0.0714285714285714 0.801539520082566 0.848499064720451 0.988344554005476 GO:0004679 AMP-activated protein kinase activity 18/1661 248/18639 0.0725806451612903 0.814467576858092 0.849838552328581 0.988344554005476 GO:0000049 tRNA binding 5/1661 80/18639 0.0625 0.701347080072246 0.851432744278464 0.988344554005476 GO:0017171 serine hydrolase activity 14/1661 198/18639 0.0707070707070707 0.793443161293854 0.851786084838885 0.988344554005476 GO:0019213 deacetylase activity 2/1661 37/18639 0.0540540540540541 0.60657044763005 0.85412170718357 0.988344554005476 GO:0140030 modification-dependent protein binding 12/1661 173/18639 0.069364161849711 0.778373637999255 0.854583004231874 0.988344554005476 GO:0004843 cysteine-type deubiquitinase activity 7/1661 108/18639 0.0648148148148148 0.727322897852699 0.857244278556819 0.988344554005476 GO:0008173 RNA methyltransferase activity 4/1661 67/18639 0.0597014925373134 0.669943479471996 0.858953219525178 0.988344554005476 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1661 21/18639 0.0476190476190476 0.534359680055044 0.859309986941445 0.988344554005476 GO:0015174 basic amino acid transmembrane transporter activity 1/1661 21/18639 0.0476190476190476 0.534359680055044 0.859309986941445 0.988344554005476 GO:0051010 microtubule plus-end binding 1/1661 21/18639 0.0476190476190476 0.534359680055044 0.859309986941445 0.988344554005476 GO:0051428 peptide hormone receptor binding 1/1661 21/18639 0.0476190476190476 0.534359680055044 0.859309986941445 0.988344554005476 GO:0140312 cargo adaptor activity 1/1661 21/18639 0.0476190476190476 0.534359680055044 0.859309986941445 0.988344554005476 GO:0008528 G protein-coupled peptide receptor activity 8/1661 122/18639 0.0655737704918033 0.735839559420061 0.861219429564111 0.988344554005476 GO:0005544 calcium-dependent phospholipid binding 3/1661 53/18639 0.0566037735849057 0.635182261197506 0.86270960076067 0.988344554005476 GO:0008146 sulfotransferase activity 3/1661 53/18639 0.0566037735849057 0.635182261197506 0.86270960076067 0.988344554005476 GO:0004620 phospholipase activity 7/1661 109/18639 0.0642201834862385 0.720650210716436 0.863505792130485 0.988344554005476 GO:0000146 microfilament motor activity 2/1661 38/18639 0.0526315789473684 0.59060806742926 0.864326400411635 0.988344554005476 GO:0042162 telomeric DNA binding 2/1661 38/18639 0.0526315789473684 0.59060806742926 0.864326400411635 0.988344554005476 GO:0019842 vitamin binding 10/1661 150/18639 0.0666666666666667 0.748103552077062 0.869896854925851 0.988344554005476 GO:0017069 snRNA binding 3/1661 54/18639 0.0555555555555556 0.623419626730885 0.871059735424911 0.988344554005476 GO:0004407 histone deacetylase activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0008649 rRNA methyltransferase activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0015377 chloride:monoatomic cation symporter activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0016881 acid-amino acid ligase activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0033038 bitter taste receptor activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0033558 protein lysine deacetylase activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0050321 tau-protein kinase activity 1/1661 22/18639 0.0454545454545455 0.510070603688906 0.871861609655499 0.988344554005476 GO:0005261 monoatomic cation channel activity 25/1661 341/18639 0.0733137829912024 0.82269452207888 0.872493558686461 0.988344554005476 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1661 39/18639 0.0512820512820513 0.575464270828509 0.873872153809745 0.988344554005476 GO:0003887 DNA-directed DNA polymerase activity 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0016917 GABA receptor activity 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0043274 phospholipase binding 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0070577 lysine-acetylated histone binding 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0140102 catalytic activity, acting on a rRNA 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0140103 catalytic activity, acting on a glycoprotein 1/1661 23/18639 0.0434782608695652 0.487893620919823 0.883294056685752 0.988344554005476 GO:0140299 molecular sensor activity 4/1661 71/18639 0.0563380281690141 0.632200184853855 0.88757718214274 0.988344554005476 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/1661 41/18639 0.0487804878048781 0.547392842983216 0.891130879116186 0.988344554005476 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1661 41/18639 0.0487804878048781 0.547392842983216 0.891130879116186 0.988344554005476 GO:0008236 serine-type peptidase activity 13/1661 194/18639 0.0670103092783505 0.751959755953748 0.891288226994073 0.988344554005476 GO:0031490 chromatin DNA binding 8/1661 128/18639 0.0625 0.701347080072246 0.893139666716027 0.988344554005476 GO:0004601 peroxidase activity 3/1661 57/18639 0.0526315789473684 0.59060806742926 0.893472337562854 0.988344554005476 GO:0004806 triacylglycerol lipase activity 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0005315 phosphate transmembrane transporter activity 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0015149 hexose transmembrane transporter activity 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0019957 C-C chemokine binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0030552 cAMP binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0050699 WW domain binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0055056 D-glucose transmembrane transporter activity 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0070300 phosphatidic acid binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0070840 dynein complex binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0140033 acetylation-dependent protein binding 1/1661 24/18639 0.0416666666666667 0.467564720048164 0.89370706548705 0.988344554005476 GO:0101005 deubiquitinase activity 7/1661 115/18639 0.0608695652173913 0.683051069287752 0.896495429181343 0.988364567186106 GO:0005537 D-mannose binding 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0015662 P-type ion transporter activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0017056 structural constituent of nuclear pore 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0019707 protein-cysteine S-acyltransferase activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0042974 nuclear retinoic acid receptor binding 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0047617 fatty acyl-CoA hydrolase activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0120020 cholesterol transfer activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0140358 P-type transmembrane transporter activity 1/1661 25/18639 0.04 0.448862131246237 0.903191490103005 0.988364567186106 GO:0003678 DNA helicase activity 4/1661 74/18639 0.0540540540540541 0.60657044763005 0.905582548378792 0.988364567186106 GO:0005253 monoatomic anion channel activity 6/1661 103/18639 0.058252427184466 0.653682715407142 0.905992785750176 0.988364567186106 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3/1661 59/18639 0.0508474576271186 0.57058745497403 0.906404531367489 0.988364567186106 GO:0031593 polyubiquitin modification-dependent protein binding 3/1661 59/18639 0.0508474576271186 0.57058745497403 0.906404531367489 0.988364567186106 GO:0008194 UDP-glycosyltransferase activity 9/1661 145/18639 0.0620689655172414 0.696510203657954 0.908008653026877 0.988364567186106 GO:0004529 DNA exonuclease activity 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0015145 monosaccharide transmembrane transporter activity 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0016289 acyl-CoA hydrolase activity 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0019865 immunoglobulin binding 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0030247 polysaccharide binding 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0050750 low-density lipoprotein particle receptor binding 1/1661 26/18639 0.0384615384615385 0.431598203121382 0.911830091958539 0.988364567186106 GO:0008234 cysteine-type peptidase activity 12/1661 187/18639 0.0641711229946524 0.720099675796103 0.914033948968178 0.989860029495746 GO:0022836 gated channel activity 22/1661 318/18639 0.0691823899371069 0.776333874796951 0.916806738189711 0.991362843698525 GO:0022804 active transmembrane transporter activity 33/1661 457/18639 0.0722100656455142 0.810309099076905 0.917589259050095 0.991362843698525 GO:0015026 coreceptor activity 3/1661 61/18639 0.0491803278688525 0.551879669565046 0.917897986838268 0.991362843698525 GO:0004497 monooxygenase activity 6/1661 106/18639 0.0566037735849057 0.635182261197506 0.919382214013701 0.991523887446105 GO:0005385 zinc ion transmembrane transporter activity 1/1661 27/18639 0.037037037037037 0.415613084487257 0.919698260295554 0.991523887446105 GO:0004252 serine-type endopeptidase activity 11/1661 176/18639 0.0625 0.701347080072246 0.922013863040208 0.991788840943286 GO:0030276 clathrin binding 2/1661 46/18639 0.0434782608695652 0.487893620919823 0.9251302726835 0.991788840943286 GO:0099094 ligand-gated monoatomic cation channel activity 8/1661 136/18639 0.0588235294117647 0.660091369479761 0.925926352826021 0.991788840943286 GO:0008527 taste receptor activity 1/1661 28/18639 0.0357142857142857 0.400769760041283 0.926864668507949 0.991788840943286 GO:0045499 chemorepellent activity 1/1661 28/18639 0.0357142857142857 0.400769760041283 0.926864668507949 0.991788840943286 GO:0051119 sugar transmembrane transporter activity 1/1661 28/18639 0.0357142857142857 0.400769760041283 0.926864668507949 0.991788840943286 GO:0051959 dynein light intermediate chain binding 1/1661 28/18639 0.0357142857142857 0.400769760041283 0.926864668507949 0.991788840943286 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1661 28/18639 0.0357142857142857 0.400769760041283 0.926864668507949 0.991788840943286 GO:1901682 sulfur compound transmembrane transporter activity 3/1661 63/18639 0.0476190476190476 0.534359680055044 0.928089071616861 0.991788840943286 GO:0061749 forked DNA-dependent helicase activity 2/1661 47/18639 0.0425531914893617 0.477512905581103 0.93060205977524 0.991788840943286 GO:0004536 DNA nuclease activity 3/1661 64/18639 0.046875 0.526010310054184 0.93273655403782 0.991788840943286 GO:0016417 S-acyltransferase activity 1/1661 29/18639 0.0344827586206897 0.386950113143308 0.933391872076177 0.991788840943286 GO:0051861 glycolipid binding 1/1661 29/18639 0.0344827586206897 0.386950113143308 0.933391872076177 0.991788840943286 GO:0004867 serine-type endopeptidase inhibitor activity 5/1661 95/18639 0.0526315789473684 0.59060806742926 0.933632103991561 0.991788840943286 GO:0008188 neuropeptide receptor activity 2/1661 48/18639 0.0416666666666667 0.467564720048164 0.935693926343315 0.991788840943286 GO:0009378 four-way junction helicase activity 2/1661 48/18639 0.0416666666666667 0.467564720048164 0.935693926343315 0.991788840943286 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1661 48/18639 0.0416666666666667 0.467564720048164 0.935693926343315 0.991788840943286 GO:0036121 double-stranded DNA helicase activity 2/1661 48/18639 0.0416666666666667 0.467564720048164 0.935693926343315 0.991788840943286 GO:0140101 catalytic activity, acting on a tRNA 8/1661 139/18639 0.0575539568345324 0.645844793160054 0.935757329031445 0.991788840943286 GO:0160215 deacylase activity 3/1661 65/18639 0.0461538461538462 0.517917843745658 0.937105740376884 0.991788840943286 GO:0004896 cytokine receptor activity 5/1661 96/18639 0.0520833333333333 0.584455900060205 0.937285873830665 0.991788840943286 GO:0048019 receptor antagonist activity 1/1661 30/18639 0.0333333333333333 0.374051776038531 0.939336853294956 0.99308412042891 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1661 31/18639 0.032258064516129 0.361985589714707 0.944751517526085 0.995304011007744 GO:0005452 solute:inorganic anion antiporter activity 1/1661 31/18639 0.032258064516129 0.361985589714707 0.944751517526085 0.995304011007744 GO:0008327 methyl-CpG binding 1/1661 31/18639 0.032258064516129 0.361985589714707 0.944751517526085 0.995304011007744 GO:0070325 lipoprotein particle receptor binding 1/1661 31/18639 0.032258064516129 0.361985589714707 0.944751517526085 0.995304011007744 GO:0005216 monoatomic ion channel activity 31/1661 448/18639 0.0691964285714286 0.776491410079986 0.947355650699082 0.996130530559471 GO:0016757 glycosyltransferase activity 17/1661 267/18639 0.0636704119850187 0.714480920523037 0.9484491521988 0.996130530559471 GO:0005272 sodium channel activity 2/1661 51/18639 0.0392156862745098 0.440060912986507 0.948925657547211 0.996130530559471 GO:0015106 bicarbonate transmembrane transporter activity 1/1661 32/18639 0.03125 0.350673540036123 0.949683145287756 0.996130530559471 GO:0120015 sterol transfer activity 1/1661 32/18639 0.03125 0.350673540036123 0.949683145287756 0.996130530559471 GO:0016298 lipase activity 7/1661 130/18639 0.0538461538461538 0.604237484369935 0.95077986057024 0.996410656670906 GO:0008175 tRNA methyltransferase activity 1/1661 34/18639 0.0294117647058824 0.33004568473988 0.958265723724499 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1661 34/18639 0.0294117647058824 0.33004568473988 0.958265723724499 1 GO:0008509 monoatomic anion transmembrane transporter activity 8/1661 149/18639 0.0536912751677852 0.602499505028506 0.960752154893342 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1661 36/18639 0.0277777777777778 0.311709813365443 0.965385095712139 1 GO:0003684 damaged DNA binding 3/1661 74/18639 0.0405405405405405 0.454927835722538 0.966129663255989 1 GO:0031491 nucleosome binding 3/1661 74/18639 0.0405405405405405 0.454927835722538 0.966129663255989 1 GO:0030280 structural constituent of skin epidermis 1/1661 37/18639 0.027027027027027 0.303285223815025 0.968475745393488 1 GO:0016758 hexosyltransferase activity 11/1661 197/18639 0.0558375634517767 0.626584193364037 0.96898790063229 1 GO:0140097 catalytic activity, acting on DNA 21/1661 336/18639 0.0625 0.701347080072246 0.971015216045261 1 GO:0042887 amide transmembrane transporter activity 1/1661 38/18639 0.0263157894736842 0.29530403371463 0.971290592555159 1 GO:0015276 ligand-gated monoatomic ion channel activity 10/1661 186/18639 0.0537634408602151 0.603309316191179 0.973544653467571 1 GO:0022834 ligand-gated channel activity 10/1661 188/18639 0.0531914893617021 0.596891131976379 0.976008026091284 1 GO:0015144 carbohydrate transmembrane transporter activity 1/1661 40/18639 0.025 0.280538832028898 0.976189080547536 1 GO:0071855 neuropeptide receptor binding 1/1661 40/18639 0.025 0.280538832028898 0.976189080547536 1 GO:0003730 mRNA 3'-UTR binding 15/1661 262/18639 0.0572519083969466 0.642455340524195 0.978888909349087 1 GO:0004520 DNA endonuclease activity 1/1661 42/18639 0.0238095238095238 0.267179840027522 0.980252189814748 1 GO:0019894 kinesin binding 1/1661 42/18639 0.0238095238095238 0.267179840027522 0.980252189814748 1 GO:0031492 nucleosomal DNA binding 1/1661 42/18639 0.0238095238095238 0.267179840027522 0.980252189814748 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1661 43/18639 0.0232558139534884 0.260966355375719 0.982015974979974 1 GO:0030246 carbohydrate binding 16/1661 280/18639 0.0571428571428571 0.641231616066053 0.982228872018449 1 GO:0038024 cargo receptor activity 2/1661 65/18639 0.0307692307692308 0.345278562497106 0.983070465227907 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 9/1661 181/18639 0.0497237569060773 0.557977787460792 0.983843833226365 1 GO:0015171 amino acid transmembrane transporter activity 4/1661 102/18639 0.0392156862745098 0.440060912986507 0.983994393791424 1 GO:0046873 metal ion transmembrane transporter activity 28/1661 450/18639 0.0622222222222222 0.698229981938591 0.986109541888292 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/1661 70/18639 0.0285714285714286 0.320615808033027 0.988694940965854 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1661 48/18639 0.0208333333333333 0.233782360024082 0.98873600872054 1 GO:0030594 neurotransmitter receptor activity 3/1661 97/18639 0.0309278350515464 0.34705834890173 0.993656761108615 1 GO:0015297 antiporter activity 5/1661 135/18639 0.037037037037037 0.415613084487257 0.994434273687926 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/1661 56/18639 0.0178571428571429 0.200384880020642 0.994673256649796 1 GO:0170055 lipid transmembrane transporter activity 1/1661 56/18639 0.0178571428571429 0.200384880020642 0.994673256649796 1 GO:0015101 organic cation transmembrane transporter activity 2/1661 81/18639 0.0246913580246914 0.277075389658171 0.995412543373372 1 GO:0140375 immune receptor activity 6/1661 156/18639 0.0384615384615385 0.431598203121382 0.99567893422729 1 GO:0005254 chloride channel activity 2/1661 83/18639 0.0240963855421687 0.270398874244721 0.99611316482402 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/1661 60/18639 0.0166666666666667 0.187025888019265 0.99633738337763 1 GO:0015103 inorganic anion transmembrane transporter activity 6/1661 165/18639 0.0363636363636364 0.408056482951125 0.997588577097422 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/1661 130/18639 0.0307692307692308 0.345278562497106 0.99775144995108 1 GO:0016874 ligase activity 6/1661 167/18639 0.0359281437125748 0.403169578963686 0.997885615259216 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1661 91/18639 0.021978021978022 0.24662754464079 0.998006197247256 1 GO:0051213 dioxygenase activity 2/1661 93/18639 0.021505376344086 0.241323726476472 0.998314460298388 1 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1661 69/18639 0.0144927536231884 0.162631206973274 0.998423663293281 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1661 73/18639 0.0136986301369863 0.15371990796104 0.998916424231707 1 GO:0015108 chloride transmembrane transporter activity 3/1661 121/18639 0.0247933884297521 0.278220329284858 0.999001284606662 1 GO:0015293 symporter activity 4/1661 146/18639 0.0273972602739726 0.30743981592208 0.999308729137802 1 GO:0008514 organic anion transmembrane transporter activity 11/1661 269/18639 0.0408921933085502 0.458873925995224 0.999312900799209 1 GO:0015370 solute:sodium symporter activity 1/1661 79/18639 0.0126582278481013 0.14204497824248 0.999382544340528 1 GO:0046943 carboxylic acid transmembrane transporter activity 6/1661 188/18639 0.0319148936170213 0.358134679185828 0.999487077815531 1 GO:0005342 organic acid transmembrane transporter activity 6/1661 189/18639 0.0317460317460317 0.356239786703363 0.999521261141846 1 GO:0003823 antigen binding 5/1661 174/18639 0.028735632183908 0.322458427619423 0.999632093262718 1 GO:0015294 solute:monoatomic cation symporter activity 2/1661 116/18639 0.0172413793103448 0.193475056571654 0.999761837051421 1 GO:0015291 secondary active transmembrane transporter activity 11/1661 287/18639 0.0383275261324042 0.43009437662967 0.999764868333704 1 GO:0015081 sodium ion transmembrane transporter activity 3/1661 164/18639 0.0182926829268293 0.205272316118706 0.999969074222237 1 GO:0005179 hormone activity 1/1661 132/18639 0.00757575757575758 0.0850117672814843 0.999995739790161 1 GO:0030371 translation repressor activity 4/1661 329/18639 0.0121580547112462 0.136432258737458 0.999999999778626 1 GO:0045182 translation regulator activity 4/1661 356/18639 0.0112359550561798 0.126084868327595 0.999999999978562 1 GO:0004984 olfactory receptor activity 1/1661 419/18639 0.00238663484486874 0.0267817500743578 1 1