category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	78/2076	142/9376	2.48082715948872	BIRC2/SIAH1/UBE2B/TRAF6/UBE2H/CUL2/CUL3/RCHY1/HERC4/UBE2L6/UBE2W/TRIP12/UBE2A/UBE2N/CUL5/VHL/CDC23/CUL1/CUL4B/UBE2Q1/MDM2/ANAPC10/BTRC/MAP3K1/UBA3/CDC26/UBE2D1/UBE2J1/UBE2S/KLHL9/UBE2E3/CDC16/UBE2J2/UBE4A/UBE2G1/UBE2D3/PML/FANCL/UBA6/NEDD4/UBE2Z/ANAPC7/UBE3A/CDC27/COP1/SKP1/SOCS1/UBE2E1/UBA2/PIAS1/RNF7/ANAPC16/UBE2R2/PIAS2/SKP2/UBE2D2/BIRC6/UBE2I/UBC/HUWE1/UBE4B/BIRC3/MID1/ANAPC1/HERC2/FBXO2/WWP1/UBB/ELOC/SMURF2/HERC3/SAE1/SMURF1/DDB2/ANAPC4/SOCS3/UBA7/UBE2M	9.48181529226779
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	105/2076	248/9376	1.91217602088383	HSP90AB1/HSP90AA1/RHOB/MLKL/NFKBIA/CASP7/FOS/BIRC2/DYNLL1/TRAF6/RIPK2/EXOC5/CASP3/JUN/LY96/HSP90B1/ARPC5L/PIK3CA/MYL12A/KPNA4/CASP4/CYCS/CDC42/WASL/MYL12B/NAIP/ARPC1B/RAB5A/DYNC1I1/DYNLT3/CASP1/ABI1/NCKAP1/ARF6/CTNNB1/M6PR/NFKB1/CYFIP1/ARPC1A/TNFRSF1A/TLR5/TNFRSF10B/KPNA3/ELMO1/ACBD3/ACTR10/WASF3/PLEKHM1/MYC/MAPK8/MAP2K3/RILP/PIK3C2B/MAP2K6/PIK3C3/IRAK4/ARL8B/EXOC2/ACTR3/EXOC4/DCTN6/MYO6/TNFSF10/PIK3C2A/IKBKB/SKP1/CYTH2/RIPK1/ACTR2/CXCL8/ARF1/AKT1/RAB5B/TRAF2/DYNLT1/RAB7A/MAPK1/TUBB2A/MAP3K7/BIRC3/PYCARD/MAPK9/DYNC1LI2/MAP2K2/BRK1/STX10/S100A10/MYD88/RELA/MAP2K4/RAB9A/FADD/RHOJ/VPS11/DYNC1H1/NOD1/MAP2K1/VPS16/ACTR3C/PODXL/SNX18/CASP8/MAPK12/PIK3CG/TAB3	7.76344639857855
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	80/2076	174/9376	2.07649547095431	HSPA1A/DNAJA1/HSPA1B/HSPH1/HSP90AB1/HSP90AA1/HSPA5/HSPA8/DDIT3/CALR/HERPUD1/DNAJB11/DNAJB1/MAN1A1/PPP1R15A/HSPA6/XBP1/HSPA4L/ERO1B/HSP90B1/PDIA6/DNAJC3/BCAP29/EIF2S1/DNAJA2/HYOU1/PDIA4/SEC24A/CUL1/STT3B/ATXN3/UBQLN2/SAR1B/UBE2D1/UBE2J1/TRAM1/MBTPS1/DNAJC10/DERL1/NGLY1/UBQLN1/UBE2J2/PDIA3/SEC23A/UBXN2A/UBE2G1/UBE2D3/MAPK8/RAD23B/ERO1A/DERL2/UFD1/TUSC3/DDOST/SKP1/EDEM3/EDEM2/SEC24B/CANX/ERN1/OSTC/RNF5/UBE2D2/EIF2AK3/TRAF2/YOD1/CAPN2/UGGT1/UBE4B/VCP/RPN1/MAPK9/UGGT2/DAD1/FBXO2/UBXN8/UBXN1/FBXO6/MAN1C1/SEC24C	7.64334740212411
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	73/2076	169/9376	1.95086135148385	CALCOCO2/TBK1/TRAF6/PIK3CA/MAP1LC3B/RAB8A/VMP1/RAB33B/NRBF2/EIF2S1/GABARAPL2/PTEN/ATG5/TANK/SUPT20H/ATG4C/STX7/MTMR4/ATG3/STX17/HIF1A/LAMP2/KRAS/ATG101/PPP2CB/PRKAA1/PLEKHM1/SH3GLB1/MAPK8/C9orf72/ZFYVE1/PIK3R4/PPP2CA/ATG12/CAMKK2/PIK3C3/WIPI2/PRKAA2/NRAS/RRAGB/ERN1/AKT1/ITPR1/EIF2AK3/ATG16L1/BIRC6/OPTN/RAB7A/PRKACB/MAPK1/DAPK1/ATG2B/UBC/STK11/MAP3K7/MAPK9/RAB1A/MAP2K2/PIK3R3/RHEB/UBB/DDIT4/IGF1R/ATG10/VPS11/MTMR3/MAP2K1/VPS16/MTOR/RRAGA/SMCR8/ATG9A/GORASP1	6.65180269845001
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	44/2076	83/9376	2.39422429602804	OGT/USP45/MGA/PHC3/UBE2D1/KDM2A/AUTS2/CBX4/MTF2/MAX/L3MBTL3/UBE2D3/ASXL2/E2F6/RNF2/PCGF5/MBD6/BCOR/PCGF3/SCML1/LCOR/EP300/FBRS/USP7/MBD5/SKP1/SUZ12/PHC2/EED/PHF1/AEBP2/HDAC1/EZH1/TFDP1/UBE2D2/ASXL1/SCML2/PHC1/RYBP/EZH2/L3MBTL4/BMI1/FOXK1/BAP1	6.80348774612091
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	87/2076	216/9376	1.8190965532006	HSPA1A/HSPA1B/HSP90AB1/HSP90AA1/HSPA5/HSPA8/CXCL2/HSPD1/DDIT3/HSPA4/VAV3/NFKBIA/CD36/CASP7/CXCL1/TBK1/IRF7/FOS/HSPA6/XBP1/SOD2/TRAF6/CAMK2D/CASP3/JUN/LY96/HSP90B1/PIK3CA/ABCG1/CYCS/PRKCA/EIF2S1/CDC42/NFATC1/PTK2/BID/PLCB1/TANK/PPP3R1/CASP1/CXCL3/NFKB1/PPP3CC/TNFRSF1A/TNFRSF10B/KRAS/PPP3CA/MAPK8/MAP2K3/PPARG/MAP2K6/IRAK4/ERO1A/STAT3/RAP1A/NRAS/TNFSF10/IKBKB/PLCB4/ERN1/APAF1/CXCL8/AKT1/ITPR1/EIF2AK3/TRAF2/CALM1/TICAM1/MAPK1/GSK3B/MAP3K7/PYCARD/MAPK9/MIB1/PPP3CB/MYD88/PIK3R3/RELA/MAP2K4/JAK2/IL12A/CASP6/CASP8/MAPK12/AGER/CALML4/RAP1B	6.49459568829637
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	97/2076	250/9376	1.75235452793834	HSPA1A/HSPA1B/HSPA8/SNX3/PARD6G/HSPA6/STAM2/VPS26A/SPART/TRAF6/CHMP5/SNX1/SNX2/ARF4/ARPC5L/TGFBR2/RAB8A/EPS15/CAPZA2/ARFGEF1/ZFYVE16/RUFY2/RUFY1/CDC42/WASL/ARPC1B/RAB5A/RAB10/MDM2/ARFGAP2/EPS15L1/ARF6/RAB11FIP3/CHMP7/ARPC1A/ZFYVE9/RAB22A/IST1/STAMBP/CHMP4B/PRKCZ/SNX4/EHD1/TSG101/PDCD6IP/SH3GLB1/PML/WASHC2A/VPS36/VPS37B/ARAP3/NEDD4/RAB35/ACTR3/ARRB1/CLTC/RAB4A/RAB11FIP5/CYTH2/RAB11A/WASHC4/VTA1/ARFGEF2/VPS37A/CHMP1B/ARFGAP3/ACTR2/ARF1/RAB5B/HLA-F/RAB7A/CHMP2B/STAM/GIT2/VPS29/VPS45/ACAP2/PIP5K1A/EHD3/WASHC5/WWP1/SPG21/SMURF2/IGF1R/SNX6/PRKCI/WASHC3/CLTA/SMAP1/SMURF1/ASAP2/LDLRAP1/ACTR3C/WASHC2C/MVB12A/VPS26B/AP2M1	6.42969236098756
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	75/2076	187/9376	1.81138141015734	HSP90AB1/HSP90AA1/OAS1/CARD6/CXCL2/OAS2/TXNIP/NFKBIA/CXCL1/TBK1/IRF7/BIRC2/TRAF6/RIPK2/JUN/SUGT1/MAP1LC3B/GBP4/CARD16/CASP4/OAS3/STAT1/GABARAPL2/TRPM7/ATG5/NAIP/CARD8/PLCB1/TANK/VDAC3/CASP1/GBP1/MFN1/ERBIN/ANTXR2/NEK7/GBP2/CXCL3/NFKB1/STAT2/TP53BP1/MAPK8/IFNAR1/ATG12/IRAK4/GBP3/VDAC2/IKBKB/IFI16/PLCB4/RIPK1/PKN2/RBCK1/VDAC1/GBP7/CXCL8/PANX1/ITPR1/TRAF2/ATG16L1/SHARPIN/TICAM1/MAPK1/MAP3K7/BIRC3/PYCARD/MAPK9/MYD88/RELA/FADD/NOD1/CASP8/MAPK12/TAB3/ITPR3	5.97653701280965
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	31/2076	56/9376	2.50013762730526	HSPA1A/HSPA1B/HSPA8/CXCL2/HSPD1/NFKBIA/CASP7/CXCL1/CLK4/HSPA6/HBS1L/CASP3/SEC22B/CLK1/CYCS/NAIP/CASP1/SAR1B/CXCL3/NFKB1/TLR5/APAF1/CXCL8/ARF1/VCP/PYCARD/RAB1A/MYD88/RELA/IL12A/CASP8	6.00419853867078
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	66/2076	163/9376	1.82871733040179	NFKBIA/DDX3X/TBK1/IRF7/FOS/SOS2/ATF2/TRAF6/CASP3/JUN/TGFBR2/PIK3CA/SOS1/CYCS/STAT1/PRKCA/SMAD4/NFATC1/CASP10/IFIH1/CDK2/RB1/BID/VDAC3/MAP3K1/EGR3/NFKB1/STAT2/CREB5/KRAS/ELK1/TGFB3/MYC/MAPK8/BRAF/MAP2K3/IFNAR1/MAP2K6/CREB1/IRAK4/YWHAQ/EP300/STAT3/NRAS/IKBKB/APAF1/CXCL8/AKT1/TICAM1/MAPK1/MAP3K7/TLR3/MAPK9/MAP2K2/PCNA/MYD88/PIK3R3/RELA/MAP2K4/JAK2/FADD/MAP2K1/DDB2/CASP8/MAPK12/CREB3L4	5.69164193338592
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	84/2076	224/9376	1.69364161849711	ZFP36/CALR/NFKBIA/NFYB/FOS/XPO1/ATF2/TBPL1/JUN/B2M/TGFBR2/PIK3CA/KAT2B/ELK4/ADCY4/SMAD4/NFATC1/CDKN2C/PTEN/CDK2/CDC23/RB1/PPP3R1/VDAC3/ANAPC10/BUB3/MAP3K1/NFKB1/PPP3CC/CDC26/TNFRSF1A/CREB5/KRAS/CDC16/PPP3CA/ELK1/TGFB3/RANBP3/MYC/DLG1/MAPK8/TRRAP/ATM/CREB1/ANAPC7/POLB/MSX1/ETS2/CCND3/EP300/VDAC2/CDC27/IL15RA/NRAS/IKBKB/ETS1/FOSL1/CANX/ATR/KAT2A/ANAPC16/VDAC1/AKT1/HLA-F/RAN/SLC25A5/PRKACB/MAPK1/RANBP1/MAPK9/ANAPC1/MAP2K2/CRTC3/PPP3CB/PIK3R3/RELA/CHEK1/MAP2K4/CRTC2/TBP/MAP2K1/ADCY6/ANAPC4/CREB3L4	5.60323747593256
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	75/2076	196/9376	1.72820573316032	ZFP36/CXCL2/NFKBIA/CLEC2B/CXCL1/TBK1/IRF7/FOS/EIF2AK2/CASP3/JUN/IFNGR1/GNB4/PIK3CA/MAP1LC3B/CYCS/STAT1/NFATC1/RB1/BID/PPP3R1/CTNNB1/ATG3/CXCL3/NFKB1/PPP3CC/STAT2/HIF1A/TNFRSF1A/KRAS/PPP3CA/GNG12/MICB/MYC/MAPK8/IFNAR1/MAP2K6/CREB1/PIK3C3/EP300/STAT3/NRAS/IKBKB/GNG5/GNG11/CXCL8/AKT1/ITPR1/TRAF2/HLA-F/CALM1/TICAM1/MAPK1/UBC/GSK3B/GNGT2/TLR3/MAPK9/MAP2K2/PPP3CB/PIK3R3/RELA/MAP2K4/GNG10/UBB/IL6ST/JAK2/FADD/MAP2K1/MTOR/CASP8/MAPK12/PIK3CG/CALML4/ITPR3	5.49412671460672
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	70/2076	180/9376	1.75636908584885	OAS1/OAS2/CALR/NFKBIA/TBK1/IRF7/SRSF7/BIRC2/SRSF1/TRAF6/EIF2AK2/PPP1CB/CASP3/SP100/B2M/IFNGR1/SRSF3/SRSF5/PIK3CA/SRSF2/ZC3HAV1/SRSF6/IFNGR2/OAS3/CYCS/STAT1/EIF2S1/IFIH1/SRSF9/PPP1CC/PILRB/BID/TAP1/BST2/NFKB1/STAT2/TNFRSF1A/CGAS/SRSF8/PDIA3/EIF2B2/TAP2/PML/IFNAR1/IRAK4/NXF1/SRPK1/IKBKB/APAF1/AKT1/TRAF2/HLA-F/EIF2B5/PTPN11/TICAM1/MAP3K7/BIRC3/TLR3/MYD88/PIK3R3/RELA/RHEB/HCFC2/JAK2/IL12A/FADD/MTOR/CASP8/SOCS3/SRSF4	5.46397148392871
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	79/2076	214/9376	1.66726090792862	CALR/NFKBIA/TBK1/FOS/TRIM5/TRAF6/CASP3/JUN/AP1G1/GNAI3/B2M/GNB4/PIK3CA/CFL2/CYCS/PRKCA/NFATC1/CUL5/PTK2/CUL1/CUL4B/BID/PPP3R1/TAP1/BST2/BTRC/NFKB1/PPP3CC/LIMK2/TNFRSF1A/CGAS/KRAS/PDIA3/PPP3CA/GNG12/TAP2/MAPK8/MAP2K3/MAP2K6/ATM/IRAK4/AP1S1/NRAS/IKBKB/SKP1/RIPK1/ATR/RNF7/WEE1/GNG5/GNG11/AKT1/ITPR1/TRAF2/HLA-F/CALM1/MAPK1/MAP3K7/GNGT2/MAPK9/MAP2K2/PPP3CB/MYD88/PIK3R3/RELA/CHEK1/GNG10/ELOC/SAMHD1/DCAF1/FADD/MAP2K1/MTOR/CASP8/MAPK12/GNAI2/CCNB1/CALML4/ITPR3	5.26556899535524
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	62/2076	157/9376	1.78353767043432	PPID/GADD45A/PPP1CB/TGFBR2/PIK3CA/SIRT1/NFATC1/TRPM7/PTEN/CDK2/PPP1CC/HUS1/RB1/PPP3R1/VDAC3/MDM2/HIPK3/BTRC/NBN/NFKB1/RBL2/PPP3CC/KRAS/PPP3CA/TGFB3/TRAF3IP2/MRE11/MYC/MAP2K3/MAP2K6/ATM/CCND3/VDAC2/HIPK1/NRAS/ETS1/RAD50/ATR/LIN9/VDAC1/CXCL8/AKT1/ITPR1/HLA-F/CALM1/SLC25A5/CAPN2/MAPK1/MAP2K2/LIN54/PPP3CB/PIK3R3/RELA/CHEK1/RHEB/MAP2K1/GADD45B/MTOR/MAPK12/CCNB1/CALML4/ITPR3	5.27965667860917
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	103/2076	300/9376	1.55062299293513	HSPA1A/HSPA1B/DUSP1/HSPA8/DDIT3/JUND/EFNA5/MKNK2/RASGRP3/FOS/CDC25B/SOS2/ATF2/IGF1/HSPA6/GADD45A/TRAF6/CASP3/HGF/JUN/STMN1/TGFBR2/SOS1/STK3/ELK4/DUSP5/PRKCA/RPS6KA3/PGF/LAMTOR3/DUSP8/CDC42/NFATC1/EFNA1/MAP3K12/FLT4/MAP3K8/PPP3R1/MAP4K2/PLA2G4C/MAP3K1/MAP4K3/NFKB1/PPP3CC/TNFRSF1A/PPM1A/DUSP6/MAX/KRAS/PPP3CA/GNG12/MAPK7/MAP3K4/ELK1/TGFB3/MEF2C/MYC/MAPK8/BRAF/MAP2K3/TEK/MAP2K6/IRAK4/PPM1B/DUSP10/ARRB1/RAP1A/NRAS/KDR/IKBKB/RASA2/NF1/AKT1/MAP3K13/TRAF2/PRKACB/MAPK1/MAPKAPK5/MAP2K5/RAPGEF2/MAP3K7/MAPK9/MAP2K2/EFNA4/ECSIT/CSF1/PPP3CB/MYD88/RELA/MAP2K4/IGF1R/MAP2K1/GADD45B/DUSP7/MAPK12/PLA2G4A/MAP3K6/MECOM/RASGRF2/RPS6KA4/KITLG/RASGRF1/RAP1B	5.16898901481782
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	62/2076	158/9376	1.77224945733031	CDKN1B/CDC25B/GADD45A/PPP2R5A/CDC14A/SMAD4/CDKN2C/STAG2/CDK2/CDC23/CUL1/RB1/STAG1/MDM2/ANAPC10/BUB3/RBL2/CDC26/ESCO1/CDC16/PPP2R5C/TGFB3/PPP2CB/MYC/YWHAG/PPP2CA/ATM/WAPL/ANAPC7/CCND3/YWHAQ/EP300/ORC4/CDC27/MCM3/CCNH/SKP1/PPP2R1B/ATR/WEE1/ANAPC16/HDAC1/SKP2/HDAC8/TFDP1/GSK3B/MAD2L1BP/ANAPC1/PPP2R5E/RAD21/TFDP2/PCNA/YWHAH/FBXO5/CHEK1/PPP2R5B/MCM6/GADD45B/ANAPC4/ORC5/ORC2/CCNB1	5.22042290016921
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	45/2076	103/9376	1.97317470116168	DDX39B/PPP2R5A/HBS1L/PPP1CB/PAPOLA/PELO/WDR33/ETF1/PPP1CC/CSTF2T/RNGTT/PAPOLG/PPP2R3C/PPP2R2D/PABPN1/CPSF6/EIF4A3/ACIN1/NXT1/PCF11/PPP2R5C/NCBP2/SMG7/PPP2CB/RNMT/PPP2CA/NUDT21/NXF1/PPP2R2A/SMG1/PPP2R1B/NCBP1/MAGOH/CSTF1/PPP2R5E/RNPS1/DAZAP1/PNN/MAGOHB/PYM1/SSU72/UPF3A/PPP2R5B/GSPT2/CSTF3	5.29586829088618
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	74/2076	200/9376	1.67105973025048	NFKBIA/CASP7/NCK1/FOS/TRAF6/CASP3/JUN/MYH10/ARPC5L/ARHGEF12/CASP4/CYCS/CDC42/SEC24A/WASL/NAIP/MYO5C/ARPC1B/CASP1/ABI1/NCKAP1/ARF6/NFKB1/CYFIP1/ARHGEF11/ARPC1A/TNFRSF1A/TLR5/TNFRSF10B/CLDN5/MYO1D/MYO1B/WASF3/MAPK8/ARHGEF2/IRAK4/ACTR3/MYO6/TNFSF10/IKBKB/NCK2/CYTH2/SEC24B/RIPK1/GNA13/ACTR2/CXCL8/ARF1/TRAF2/BAIAP2/PTPN11/MAPK1/TUBB2A/OCLN/MAP3K7/PYCARD/MAPK9/RAB1A/BRK1/FYN/MYD88/RELA/CLDN14/FADD/BAIAP2L1/ACTR3C/CASP8/CLDN12/WASF1/MAPK12/TJP1/SEC24C/TAB3/TMBIM6	5.11549136668555
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	61/2076	156/9376	1.76601946544143	IFIT1/MX1/OAS1/OAS2/RSAD2/NFKBIA/MX2/TBK1/IRF7/SOS2/TRAF6/EIF2AK2/CASP3/PIK3CA/SOS1/OAS3/CYCS/STAT1/EIF2S1/CDK2/RB1/BID/CTNNB1/PPP2R2D/NFKB1/STAT2/TNFRSF1A/CLDN5/KRAS/PPP2CB/MYC/YWHAG/BRAF/IFNAR1/PPP2CA/YWHAQ/STAT3/NRAS/PPP2R2A/IKBKB/PIAS1/RIPK1/PPP2R1B/APAF1/AKT1/TRAF2/TICAM1/MAPK1/GSK3B/OCLN/TLR3/MAP2K2/YWHAH/PIK3R3/RELA/CLDN14/FADD/MAP2K1/CASP8/CLDN12/SOCS3	5.14487143987122
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	61/2076	157/9376	1.75477093381442	CALR/CD36/CASP7/CAMK2D/CASP3/ADAM17/CD47/GAS6/SIRT1/DUSP5/ANO6/DUSP8/ITGAV/NFATC1/DOCK1/ARG2/PTK2/TMEM30A/RAB5A/ATP11B/CASP1/ATP2A2/HIF1A/ELMO1/SCARF1/SIRPA/PROS1/PECAM1/S1PR1/PPARG/TGFBRAP1/CREB1/NR1H2/ADAM10/ATP11A/LIPA/BCAR1/CPT1A/VPS8/PANX1/RAB5B/UQCRFS1/PTPN11/RAB7A/MAPK1/PPARD/MAP2K2/ATP8A1/DNMT3A/JAK2/PLA2G15/VPS11/MERTK/MAP2K1/STAB2/VPS16/ODC1/DUSP7/MAPK12/AGER/XKR6	5.08581980407459
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	88/2076	253/9376	1.57091396498283	PPID/NFKBIA/CALCOCO2/FNBP1L/TIFA/TBK1/TRAF6/RIPK2/JUN/ARPC5L/PIK3CA/MYL12A/MAP1LC3B/CASP4/CYCS/UBE2N/CDC42/TECPR1/DOCK1/BCL10/ATG5/PTK2/CUL1/WASL/MYL12B/NAIP/ARPC1B/PLCB1/CASP1/MDM2/BTRC/ARF6/NFKB1/UBE2D1/ARPC1A/TNFRSF1A/TLR5/CGAS/ELMO1/UBE2D3/MAPK8/ARHGEF2/PIK3R4/ATG12/ATM/PIK3C3/WIPI2/ACTR3/IKBKB/SKP1/CYTH2/PLCB4/BCAR1/RIPK1/RRAGB/RBCK1/VDAC1/ACTR2/PLCE1/CXCL8/ARF1/UBE2D2/AKT1/ITPR1/TRAF2/ATG16L1/SHARPIN/CAPN2/MAPK1/UBC/GSK3B/MAP3K7/PYCARD/MAPK9/MYD88/PIK3R3/RELA/HK1/MALT1/UBB/NOD1/ACTR3C/MTOR/WASF1/MAPK12/RRAGA/TAB3/ITPR3	4.90907844715692
Human Diseases	Infectious disease: viral	hsa05162	Measles	54/2076	136/9376	1.79326759605576	HSPA1A/HSPA1B/MX1/OAS1/HSPA8/OAS2/NFKBIA/MX2/CDKN1B/TBK1/IRF7/FOS/HSPA6/TRAF6/EIF2AK2/CASP3/JUN/BBC3/PIK3CA/RCHY1/OAS3/CYCS/STAT1/EIF2S1/CD46/IFIH1/CDK2/BID/NFKB1/STAT2/ADAR/CSNK2A2/MAPK8/IFNAR1/IRAK4/CCND3/STAT3/CLEC4M/IKBKB/MSN/APAF1/AKT1/CSNK2A1/GSK3B/MAP3K7/MAPK9/MYD88/PIK3R3/RELA/RAB9A/EIF3H/IL12A/FADD/CASP8	4.9692525080953
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	53/2076	133/9376	1.79975951439292	KLF2/CDKN1B/SOS2/IGF1/GADD45A/SOD2/DEPP1/TGFBR2/PIK3CA/SOS1/SIRT1/PLK2/HOMER3/BCL2L11/SMAD4/GABARAPL2/PTEN/CDK2/PLK3/SGK3/MDM2/RBL2/KRAS/TGFB3/S1PR1/PRKAA1/MAPK8/BRAF/ATG12/ATM/EP300/STAT3/PRKAA2/CCNG2/USP7/NRAS/TNFSF10/IKBKB/SKP2/AKT1/MAPK1/STK11/MAPK9/MAP2K2/PIK3R3/CSNK1E/IGF1R/CAT/MAP2K1/GADD45B/RAG1/MAPK12/CCNB1	4.95355103878438
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	54/2076	137/9376	1.78017805155901	DDIT3/NFKBIA/CASP7/FOS/BIRC2/PARP4/GADD45A/CASP3/JUN/BBC3/PMAIP1/MCL1/PIK3CA/BCL2L11/CYCS/EIF2S1/CASP10/BID/NFKB1/TNFRSF1A/TNFRSF10B/KRAS/MAPK8/CASP2/ATM/SPTAN1/NRAS/TNFSF10/IKBKB/RIPK1/ERN1/APAF1/AKT1/ITPR1/EIF2AK3/TRAF2/CTSH/CAPN2/MAPK1/BIRC3/MAPK9/AIFM1/MAP2K2/PARP2/HTRA2/PIK3R3/RELA/IL3RA/FADD/CASP6/MAP2K1/GADD45B/CASP8/ITPR3	4.90545629872584
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	45/2076	108/9376	1.88182402055234	IPO11/DDX39B/XPO1/SUMO1/KPNA4/NUP54/AHCTF1/NMD3/THOC1/NUP58/NUP153/THOC7/EIF4A3/KPNA3/ACIN1/NXT1/NUP50/NCBP2/TNPO1/TMEM33/NUP98/SUMO2/IPO5/NXF1/SUMO4/XPO4/IPO7/NCBP1/SENP2/MAGOH/RAN/NUP205/THOC3/UBE2I/NUP155/RNPS1/NUP107/POM121C/PNN/XPOT/MAGOHB/NUP35/PYM1/UPF3A/XPO5	4.91517146332985
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	39/2076	90/9376	1.95709698137444	NFKBIA/FOS/TRAF6/JUN/IFNGR1/PIK3CA/IFNGR2/STAT1/NFATC1/PTEN/PPP3R1/NFKB1/PPP3CC/CSNK2A2/HIF1A/KRAS/PPP3CA/MAP2K3/MAP2K6/NFKBIE/BATF3/STAT3/NRAS/IKBKB/AKT1/CSNK2A1/PTPN11/TICAM1/MAPK1/MAP2K2/PPP3CB/MYD88/PIK3R3/RELA/JAK2/CD274/MAP2K1/MTOR/MAPK12	4.86520051762149
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	48/2076	119/9376	1.82173216107252	CXCL2/MLKL/NFKBIA/CASP7/CXCL1/FOS/ATF2/BIRC2/LIF/CASP3/JUN/ADAM17/JUNB/CYLD/PIK3CA/CASP10/MAP3K8/CXCL3/NFKB1/TNFRSF1A/CREB5/FRMD8/BAG4/MAPK8/MAP2K3/MAP2K6/CREB1/IKBKB/RIPK1/AKT1/TRAF2/MAPK1/MAP3K7/BIRC3/MAPK9/CSF1/PIK3R3/RELA/MAP2K4/FADD/MAP2K1/CASP8/MAPK12/JAG1/TAB3/SOCS3/RPS6KA4/CREB3L4	4.81068052251278
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	53/2076	138/9376	1.7345508363352	VAV3/NFKBIA/TBK1/FOS/ARHGEF7/TRAF6/JUN/ARPC5L/PIK3CA/ARHGEF12/SKAP2/RPS6KA3/CDC42/NFATC1/DOCK1/PTK2/WASL/ARPC1B/CASP1/ARF6/NFKB1/ARPC1A/ELMO1/MAPK8/MAP2K3/MAP2K6/IRAK4/ACTR3/IKBKB/BCAR1/PKN2/ACTR2/CXCL8/AKT1/TRAF2/BAIAP2/ARHGEF28/TICAM1/MAPK1/GSK3B/MAP3K7/GIT2/PYCARD/MAPK9/MAP2K2/PIP5K1A/MYD88/PIK3R3/RELA/MAP2K4/MAP2K1/ACTR3C/MAPK12	4.63564643504214
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	23/2076	44/9376	2.3608337712384	TBPL1/TAF13/TAF7/GTF2H2/GTF2A2/GTF2B/GTF2A1/GTF2F1/GTF2I/MNAT1/TAF11/CCNH/GTF2H1/TAF15/GTF2E1/TAF8/TAF12/TAF9/ERCC3/GTF2H5/TAF4/TBP/TAF5	4.82482909466397
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	48/2076	122/9376	1.77693546858713	FOS/SOS2/ATF2/IGF1/GNAI3/JUNB/PIK3CA/SOS1/ADCY4/STAT1/PRKCA/GNAS/SOCS2/PTK2/PLCB1/MAP3K1/CREB5/KRAS/MAPK8/MAP2K3/MAP2K6/CREB1/EP300/STAT3/NRAS/SOCS1/PLCB4/BCAR1/SHC1/AKT1/ITPR1/PRKACB/MAPK1/GSK3B/MAPK9/MAP2K2/PIK3R3/MAP2K4/JAK2/MAP2K1/ADCY6/MTOR/MAPK12/GNAI2/SHC2/SOCS3/CREB3L4/ITPR3	4.60614917303952
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	39/2076	93/9376	1.89396482068494	YES1/TGFBR2/SNAI1/MYL12A/SMAD4/FER/CDC42/NECTIN3/RADIL/WASL/MYL12B/AFDN/CTNNB1/ACP1/CSNK2A2/PDCD10/ARHGAP29/CTNND1/SNAI2/WASF3/EP300/CDH5/RAP1A/FARP2/CTNNA1/BAIAP2/CSNK2A1/MAPK1/PTPRM/MAP3K7/FYN/SMURF2/IGF1R/SSX2IP/SMURF1/WASF1/HEG1/TJP1/RAP1B	4.62014505054875
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	37/2076	87/9376	1.92075831063274	FOS/SOS2/GADD45A/CASP3/JUN/BBC3/POLK/PMAIP1/TGFBR2/PIK3CA/SOS1/BCL2L11/CYCS/SMAD4/RALB/MSH6/CTNNB1/KRAS/TGFB3/MYC/MAPK8/BRAF/NRAS/APC/MSH2/MSH3/AKT1/MAPK1/GSK3B/MAPK9/MAP2K2/PIK3R3/MLH1/MAP2K1/GADD45B/DDB2/MTOR	4.60106824573495
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	32/2076	72/9376	2.00727895525583	NFKBIA/DDX3X/TBK1/IRF7/TRAF6/AZI2/ISG15/RNF125/CYLD/TRIM25/CASP10/IFIH1/ATG5/TANK/MAP3K1/NFKB1/ADAR/MAPK8/ATG12/IKBKB/RIPK1/CXCL8/TRAF2/OTUD5/MAP3K7/DHX58/MAPK9/RELA/IL12A/FADD/CASP8/MAPK12	4.57529436127561
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	144/2076	480/9376	1.35491329479769	PPID/HSPA5/DDIT3/CASP7/PSMA2/TBK1/XBP1/SDHD/CAMK2D/CASP3/PSMD12/MAP1LC3B/RAB8A/NDUFB5/UBE2L6/NRBF2/CYCS/PRKCA/EIF2S1/FZD6/RAB5A/BID/NDUFC2/PLCB1/NDUFB3/TANK/PPP3R1/VDAC3/IFT57/SNCAIP/ATXN3/CTNNB1/MFN1/ATP2A2/NFKB1/PSMC6/PPP3CC/CSNK2A2/UBE2J1/TNFRSF1A/APP/DERL1/KRAS/UBE2J2/NDUFV2/PPP3CA/FRAT2/ATG101/VAPB/UBE2G1/MT-ND6/ACTR10/MAPK8/C9orf72/PSMB2/BRAF/MAP2K3/ZFYVE1/PIK3R4/MAP2K6/PSMD11/PIK3C3/WIPI2/PSMA3/VDAC2/NDUFA5/PSEN1/DCTN6/ATXN2/UQCRC2/NRAS/PSMA5/SOD1/PSMC2/CSNK1A1/ATP5F1C/APC/PLCB4/SNCA/ERN1/NDUFA8/PSMA1/ATXN2L/VDAC1/APAF1/GRIN2B/NDUFS4/ITPR1/EIF2AK3/TRAF2/NDUFA7/UQCRFS1/CSNK2A1/NDUFC1/CALM1/SLC25A5/OPTN/NDUFB8/LRP6/CAPN2/ALS2/MAPK1/CHMP2B/TUBB2A/NDUFB4/HSD17B10/ATG2B/UBC/GSK3B/VCP/ATXN1L/MAPK9/RAB1A/COX7A2L/MAP2K2/UQCRH/NDUFB6/SDHB/NDUFA6/PINK1/HTRA2/CSF1/PPP3CB/RELA/CSNK1E/PSMB5/UBB/HIP1/NDUFA9/SDHC/FADD/CAT/FZD9/MAP2K1/PARK7/MTOR/CASP8/MAPK12/COX7B/SMCR8/AGER/CALML4/UBA7/ITPR3	4.25680133686969
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	62/2076	173/9376	1.61858620958491	MX1/OAS1/OAS2/RSAD2/NFKBIA/MX2/DNAJB1/CALCOCO2/TBK1/IRF7/XPO1/EIF2AK2/CASP3/IFNGR1/PIK3CA/DNAJC3/IFNGR2/OAS3/CYCS/STAT1/PRKCA/EIF2S1/TRIM25/IFIH1/BID/CASP1/NFKB1/STAT2/ADAR/PABPN1/TNFRSF1A/TNFRSF10B/NXT1/PML/IFNAR1/NUP98/IRAK4/CCND3/EP300/NXF1/TNFSF10/IKBKB/RAB11A/VDAC1/APAF1/CXCL8/AKT1/SLC25A5/TICAM1/MAPK1/TLR3/PYCARD/MAP2K2/MYD88/PIK3R3/RELA/JAK2/IL12A/FADD/MAP2K1/CASP8/SOCS3	4.37921691073203
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	77/2076	227/9376	1.5319871321501	CALR/NFKBIA/TBK1/SOS2/ATF2/CASP3/GNAI3/B2M/GNB4/PIK3CA/SOS1/ARHGEF12/ADCY4/CYCS/PRKCA/GNAS/ITGAV/NFATC1/PTK2/RB1/BID/PLCB1/PPP3R1/TAP1/MDM2/CTNNB1/NFKB1/PPP3CC/ARHGEF11/TNFRSF1A/CGAS/CREB5/SP1/KRAS/PDIA3/PPP3CA/GNG12/ELK1/TAP2/MYC/MAP2K6/CREB1/STAT3/NRAS/IKBKB/PLCB4/BCAR1/RIPK1/GNA13/GNG5/GNG11/CXCL8/AKT1/ITPR1/TRAF2/HLA-F/CALM1/PRKACB/MAPK1/GSK3B/GNGT2/MAP2K2/PPP3CB/PIK3R3/RELA/RHEB/GNG10/FADD/MAP2K1/ADCY6/MTOR/CASP8/MAPK12/GNAI2/CALML4/CREB3L4/ITPR3	4.32678310387939
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	47/2076	122/9376	1.73991597965823	VAV3/NFKBIA/NCK1/FOS/SOS2/PPP2R5A/JUN/PIK3CA/SOS1/CDC42/NFATC1/BCL10/MAP3K8/PPP3R1/PPP2R3C/PPP2R2D/NFKB1/PPP3CC/KRAS/PPP3CA/PPP2R5C/PPP2CB/DLG1/MAPK8/PPP2CA/NFKBIE/NRAS/PPP2R2A/IKBKB/NCK2/PPP2R1B/AKT1/PTPN11/MAPK1/GSK3B/MAP3K7/MAPK9/PPP2R5E/MAP2K2/PPP3CB/FYN/PIK3R3/RELA/MALT1/PPP2R5B/MAP2K1/MAPK12	4.38667497574707
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/2076	78/9376	1.91077515933007	HSPD1/C1D/BTG2/DDX6/XRN1/TOB1/DCP2/BTG3/PATL1/CNOT2/LSM6/LSM8/PNPT1/CNOT7/HSPA9/CNOT6L/LSM1/CNOT4/CNOT10/EXOSC10/CNOT6/CNOT8/LSM2/CNOT9/PAN3/DCP1A/EXOSC8/BTG1/DCPS/XRN2/DIS3/EDC4/PAN2	4.30726498131269
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	32/2076	75/9376	1.9269877970456	IGF1/SIAH1/GADD45A/CASP3/BBC3/PMAIP1/RCHY1/CYCS/PTEN/CDK2/BID/CCNG1/MDM2/TNFRSF10B/PPM1D/ATM/SESN1/CCND3/CCNG2/EI24/COP1/ATR/APAF1/MDM4/RRM2B/CHEK1/GADD45B/DDB2/CASP8/SESN2/GORAB/CCNB1	4.29811181391163
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	28/2076	63/9376	2.00727895525583	ALDH2/NSD1/ALDH9A1/ALDH3A2/NSD3/DLST/PHYKPL/SMYD2/SETD2/HADH/PLOD2/KMT5A/EHMT1/KMT5B/ACAT2/EZH1/TMLHE/DLD/SETDB2/EZH2/AASS/CAMKMT/SETDB1/ECHS1/NSD2/DOT1L/SUV39H2/MECOM	4.27772750771945
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	56/2076	157/9376	1.61093725071487	DDIT3/CASP7/FOS/XBP1/SDHD/CASP3/JUN/PIK3CA/NDUFB5/BCL2L11/CYCS/EIF2S1/CDC42/BID/NDUFC2/NDUFB3/NFKB1/TNFRSF1A/ADIPOR2/NDUFV2/PRKAA1/MAPK8/ADIPOR1/PPARG/MLXIP/NDUFA5/PRKAA2/UQCRC2/IKBKB/ERN1/NDUFA8/CXCL8/NDUFS4/AKT1/EIF2AK3/TRAF2/NDUFA7/UQCRFS1/NDUFC1/NDUFB8/NDUFB4/GSK3B/MAPK9/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/PIK3R3/RELA/NDUFA9/SDHC/CASP8/MAPK12/COX7B/SOCS3	4.11663543140172
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	30/2076	70/9376	1.93559042113955	SOS2/HGF/JUN/CUL2/GAB1/PIK3CA/SOS1/CDC42/VHL/HIF1A/KRAS/TGFB3/BRAF/EP300/RAP1A/NRAS/ETS1/PRCC/FLCN/AKT1/PTPN11/MAPK1/FH/MAP2K2/PIK3R3/ELOC/EGLN1/MAP2K1/EGLN3/RAP1B	4.18977928649007
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	52/2076	144/9376	1.63091415114537	PSMA2/TBPL1/XBP1/PSMD12/PIK3CA/OPA1/NRBF2/CYCS/PRKCA/GTF2B/PLCB1/VDAC3/ATXN3/ATP2A2/PSMC6/SP1/RELN/NFYA/ATG101/MAPK8/PSMB2/PIK3R4/PSMD11/PIK3C3/WIPI2/OMA1/PSMA3/VDAC2/ATXN2/PSMA5/PSMC2/PLCB4/ERN1/PSMA1/ATXN2L/VDAC1/GRIN2B/AKT1/ITPR1/TRAF2/SLC25A5/ATXN10/ATG2B/ATXN1L/MAPK9/PUM2/PIK3R3/PSMB5/TBP/MTOR/CIC/ITPR3	4.06856725485048
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	45/2076	120/9376	1.69364161849711	NFKBIA/SOS2/TRAF6/RIPK2/CAMK2D/JUN/GAB1/PIK3CA/SOS1/RPS6KA3/CDC42/MAP3K1/NFKB1/IRAK3/KIDINS220/KRAS/MAPK7/MAPK8/BRAF/NFKBIE/IRAK4/PSEN1/RAP1A/NRAS/IKBKB/IRAK2/SHC1/ZNF274/AKT1/CALM1/PTPN11/MAPK1/MAP2K5/GSK3B/MAPK9/MAP2K2/PIK3R3/RELA/MAP2K1/MAPK12/SHC2/SH2B3/CALML4/RAP1B/FRS2	4.07804464243751
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	32/2076	77/9376	1.87693616595351	NFKBIA/CDKN1B/SOS2/GADD45A/POLK/TGFBR2/PIK3CA/SOS1/SMAD4/RB1/MDM2/NFKB1/KRAS/TGFB3/MYC/BRAF/NRAS/IKBKB/SHC1/HDAC1/AKT1/PTPN11/MAPK1/MAP2K2/PIK3R3/RELA/MAP2K1/GADD45B/DDB2/CTBP1/MECOM/SHC2	4.12034045887492
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	17/2076	32/9376	2.39932562620424	CASP7/BIRC2/CASP3/BBC3/PMAIP1/BCL2L11/CYCS/BID/TNFRSF1A/MAPK8/APAF1/BIRC6/BIRC3/MAPK9/HTRA2/FADD/CASP8	4.22829465896174
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	38/2076	98/9376	1.75124847626912	PIK3CA/MTMR2/PRKCA/IMPA1/MTMR6/PTEN/PPIP5K2/IPMK/PLCB1/MTMR4/PIP4K2A/CDS2/SYNJ1/PIK3C2B/PIK3C3/PIP4P2/PI4KB/PIK3C2A/DGKE/PLCB4/IP6K1/SACM1L/PLCE1/MTM1/ITPR1/CALM1/IPPK/PIKFYVE/PIP5K1A/PIK3R3/DGKZ/PIP4P1/SYNJ2/CDIPT/INPP1/MTMR3/CALML4/ITPR3	3.98664294377229
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	40/2076	105/9376	1.72052481879071	CALCOCO2/TBK1/SIAH1/JUN/MAP1LC3B/OPA1/MTX2/EIF2S1/GABARAPL2/RHOT1/RAB5A/MFN1/USP15/TBC1D15/CSNK2A2/HIF1A/SP1/KRAS/MAPK8/NRAS/ARIH1/CCZ1B/RAB5B/EIF2AK3/TRAF2/CSNK2A1/OPTN/RAB7A/UBC/HUWE1/VCP/MAPK9/PINK1/RELA/UBB/SMURF2/CCZ1/MTX3/SMURF1/ATG9A	3.95929796409051
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	48/2076	133/9376	1.62997088095962	FOS/ATF2/PPP2R5A/CAMK2D/PPP1CB/GNAI3/GNB4/PRKCA/GNAS/PPP1CC/PLCB1/PPP2R3C/PPP2R2D/PPP3CC/CREB5/PPP3CA/GNG12/PPP2R5C/PPP2CB/MAPK8/PPP2CA/CREB1/ARRB1/PPP2R2A/PLCB4/PPP2R1B/GNG5/GNG11/GRIN2B/AKT1/ITPR1/CALM1/PRKACB/GSK3B/GNGT2/MAPK9/PPP2R5E/CLOCK/LRTOMT/PPP3CB/GNG10/COMT/PPP2R5B/MAPK12/GNAI2/CALML4/CREB3L4/ITPR3	3.90191408244794
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	33/2076	83/9376	1.79566822202103	HSD17B4/SOD2/ACSL3/PEX13/FAR1/SCP2/AGPS/ABCD4/IDH1/PEX2/PHYH/CROT/NUDT7/SOD1/FAR2/ABCD3/DHRS4/ECI2/GNPAT/PEX1/ACSL4/PECR/MPV17L2/PRDX1/GSTK1/CAT/PEX14/HACL1/ACOT8/EPHX2/NUDT12/NUDT19/PXMP2	3.88267441179997
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	45/2076	125/9376	1.62589595375723	PPP2R5A/GNAI3/PIK3CA/PRKCA/PTEN/CERS2/ORMDL1/BID/DEGS1/PLCB1/PPP2R3C/PPP2R2D/NFKB1/TNFRSF1A/SPTLC2/KRAS/PRKCZ/PPP2R5C/PPP2CB/S1PR1/MAPK8/PPP2CA/SPTLC1/NRAS/PPP2R2A/PLCB4/GNA13/PPP2R1B/AKT1/TRAF2/MAPK1/SGMS1/MAPK9/PPP2R5E/MAP2K2/NSMAF/FYN/PIK3R3/RELA/ABCC1/PPP2R5B/MAP2K1/MAPK12/GNAI2/FCER1A	3.75664963820181
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	67/2076	205/9376	1.47608440246252	OAS1/OAS2/CALR/NFKBIA/CDKN1B/TBK1/IRF7/GADD45A/TRAF6/EIF2AK2/HES1/CASP3/JUN/ISG15/B2M/POLK/PSMD12/PIK3CA/SAP30L/SAP30/BCL2L11/OAS3/CYCS/STAT1/SIN3A/CDK2/RB1/BID/TAP1/MDM2/NFKB1/PSMC6/STAT2/PDIA3/TAP2/MYC/MAPK8/MAP2K3/IFNAR1/MAP2K6/PSMD11/NFKBIE/IRAK4/NEDD4/CCND3/STAT3/USP7/IKBKB/PSMC2/RIPK1/HDAC1/SKP2/APAF1/AKT1/TRAF2/HLA-F/MAP3K7/MAPK9/MYD88/PIK3R3/RELA/MAP2K4/FADD/GADD45B/DDB2/CASP8/MAPK12	3.67527990324245
Genetic Information Processing	Transcription	hsa03040	Spliceosome	77/2076	243/9376	1.4311155514324	HSPA1A/HSPA1B/HSPA8/DDX5/TRA2A/DDX39B/SRSF7/HSPA6/SRSF1/HNRNPA3/SRSF3/SRSF5/SRSF2/SRSF10/SF3B1/SRSF6/BCAS2/PHF5A/SNRPA1/SRSF9/RBMXL1/CRNKL1/PRPF38A/THOC1/USP39/PRPF3/PRPF8/LSM6/PRPF18/WBP11/LSM8/HNRNPU/THOC7/DHX15/EIF4A3/DHX8/SF3B3/SNRNP40/ACIN1/SRSF8/BUD31/NCBP2/TRA2B/AQR/ISY1/RBM22/SMNDC1/SF3B6/CWC15/DDX23/NCBP1/LSM2/HNRNPA1/MAGOH/PPIH/SF1/THOC3/CDC40/CHERP/HNRNPK/PLRG1/SNRPB2/YJU2/PRPF31/BUD13/SNRPE/SNRPF/SNIP1/MAGOHB/PPIL1/SNRPG/RBM17/RBMX2/HNRNPC/SF3B5/DHX16/SRSF4	3.63101447263727
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	31/2076	78/9376	1.79497060421916	PIK3CA/MTMR2/IMPA1/MTMR6/PTEN/PPIP5K2/IPMK/PLCB1/MTMR4/PIP4K2A/SYNJ1/PIK3C2B/PIK3C3/PI4KB/PIK3C2A/PLCB4/MINPP1/IP6K1/SACM1L/PLCE1/MTM1/IPPK/PIKFYVE/PIP5K1A/ALDH6A1/SYNJ2/CDIPT/INPP1/INPP5K/MTMR3/PIK3CG	3.75959863381082
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	37/2076	99/9376	1.68793912146513	CDKN1B/FOS/SOS2/IGF1/JUN/DLL4/PIK3CA/SOS1/ADCY4/GNAS/CDKN2C/PTK2/RB1/MDM2/NOTCH1/SP1/KRAS/MAPK8/BRAF/NRAS/HBEGF/SHC1/NCOA3/AKT1/PRKACB/MAPK1/MAPK9/MAP2K2/PIK3R3/IGF1R/MAP2K1/ADCY6/MTOR/MAPK12/JAG1/SHC2/ESR2	3.66945620854063
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	48/2076	138/9376	1.57091396498283	IGF1/PPP2R5A/CAMK2D/PPP1CB/ADCY4/RPS6KA3/CDK2/CDC23/PPP1CC/CUL1/PPP3R1/CPEB2/ANAPC10/BTRC/PPP3CC/CDC26/CDC16/PPP3CA/PPP2R5C/PPP2CB/YWHAG/PPP2CA/ANAPC7/YWHAQ/CDC27/SKP1/PPP2R1B/ANAPC16/ITPR1/CALM1/PRKACB/MAPK1/ANAPC1/PPP2R5E/YWHAH/PPP3CB/FBXO5/SPDYA/IGF1R/PPP2R5B/MAP2K1/ADCY6/SLK/MAPK12/ANAPC4/CCNB1/CALML4/ITPR3	3.60295728433516
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	38/2076	103/9376	1.66623641431431	CALR/NFKBIA/FOS/TRAF6/JUN/GNAI3/IFNGR1/TGFBR2/PIK3CA/IFNGR2/GNAS/PLCB1/PPP2R2D/NFKB1/TNFRSF1A/TGFB3/PPP2CB/MAPK8/PPP2CA/IRAK4/PPP2R2A/IKBKB/PLCB4/PPP2R1B/CXCL8/AKT1/TICAM1/MAPK1/MAPK9/MYD88/PIK3R3/RELA/MAP2K4/IL12A/FADD/CASP8/MAPK12/GNAI2	3.62555694942451
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	16/2076	32/9376	2.25818882466281	GABARAPL2/ATG5/ATG4C/ATG3/ATG101/PPP2CB/PIK3R4/PPP2CA/ATG12/PIK3C3/WIPI2/ATG16L1/ATG2B/ATG10/MTOR/ATG9A	3.80182638526955
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	34/2076	90/9376	1.70618711196746	ATF2/IGF1/SOD2/PIK3CA/SIRT1/ADCY4/ATG5/NFKB1/CREB5/KRAS/ADIPOR2/ATG101/PRKAA1/ADIPOR1/PPARG/CAMKK2/CREB1/EIF4E/SESN1/PRKAA2/NRAS/EHMT1/AKT1/PRKACB/STK11/PIK3R3/RELA/RHEB/IGF1R/CAT/ADCY6/MTOR/SESN2/CREB3L4	3.58975314888969
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	53/2076	158/9376	1.51498743933075	SOS2/IGF1/PIK3CA/SOS1/PRKCA/RPS6KA3/LAMTOR3/PTEN/RNF152/FZD6/RICTOR/ATP6V1C1/PRR5/TNFRSF1A/KRAS/FNIP1/FNIP2/PRKAA1/BRAF/EIF4E/LPIN2/PRKAA2/NRAS/IKBKB/RRAGB/FLCN/SKP2/AKT1/PRR5L/LRP6/MAPK1/TTI1/STK11/GSK3B/EIF4B/MAP2K2/ATP6V1G1/CASTOR1/PIK3R3/RHEB/DDIT4/IGF1R/FZD9/SLC38A9/ATP6V1E2/MAP2K1/LAMTOR5/MTOR/WDR59/RRAGA/SESN2/NPRL2/WDR24	3.48132613893418
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	108/2076	368/9376	1.32545865795426	HSPA5/DDIT3/HNRNPA2B1/PSMA2/TBK1/SRSF7/XBP1/SDHD/CASP3/HNRNPA3/SRSF3/PSMD12/MAP1LC3B/RAB8A/NDUFB5/NUP54/NRBF2/CYCS/EIF2S1/RAB5A/BID/NUP58/NDUFC2/NDUFB3/TANK/PPP3R1/SETX/CASP1/UBQLN2/PSMC6/PPP3CC/NUP153/TNFRSF1A/ANXA7/DERL1/UBQLN1/NDUFV2/PPP3CA/NXT1/ATG101/NUP50/VAPB/MT-ND6/ACTR10/C9orf72/PSMB2/MAP2K3/PIK3R4/MAP2K6/NUP98/PSMD11/PIK3C3/WIPI2/PSMA3/NXF1/NDUFA5/DCTN6/ATXN2/UQCRC2/PSMA5/SOD1/PSMC2/ATP5F1C/ERN1/NDUFA8/PSMA1/NCBP1/ATXN2L/HNRNPA1/VDAC1/APAF1/GRIN2B/NDUFS4/EIF2AK3/TRAF2/NDUFA7/UQCRFS1/NDUFC1/OPTN/NDUFB8/ALS2/NUP205/CHMP2B/TUBB2A/NDUFB4/ATG2B/VCP/NUP155/RAB1A/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/PINK1/NUP107/PPP3CB/PSMB5/POM121C/NDUFA9/SDHC/NUP35/CAT/MTOR/MAPK12/COX7B/SMCR8/ITPR3	3.3965923926668
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	113/2076	388/9376	1.31533678962318	PPID/DDIT3/CASP7/PSMA2/XBP1/SDHD/EIF2AK2/CASP3/ADAM17/PSMD12/PIK3CA/NDUFB5/NRBF2/CYCS/EIF2S1/SLC39A1/NAE1/FZD6/BID/NDUFC2/PLCB1/NDUFB3/PPP3R1/VDAC3/SLC39A14/CTNNB1/ATP2A2/NFKB1/PSMC6/PPP3CC/CSNK2A2/RTN3/TNFRSF1A/APP/KRAS/NDUFV2/PPP3CA/FRAT2/ATG101/MT-ND6/MAPK8/PSMB2/BRAF/PIK3R4/PSMD11/PIK3C3/WIPI2/PSMA3/VDAC2/NDUFA5/PSEN1/ADAM10/UQCRC2/NRAS/PSMA5/IKBKB/PSMC2/CSNK1A1/ATP5F1C/APC/PLCB4/SNCA/ERN1/NDUFA8/PSMA1/IDE/VDAC1/APAF1/GRIN2B/NDUFS4/AKT1/ITPR1/EIF2AK3/TRAF2/NDUFA7/UQCRFS1/CSNK2A1/NDUFC1/CALM1/SLC25A5/NDUFB8/LRP6/CAPN2/MAPK1/TUBB2A/NDUFB4/HSD17B10/ATG2B/GSK3B/MAPK9/COX7A2L/MAP2K2/UQCRH/NDUFB6/SDHB/NDUFA6/CSF1/PPP3CB/PIK3R3/RELA/CSNK1E/PSMB5/NDUFA9/SDHC/FADD/FZD9/MAP2K1/MTOR/CASP8/COX7B/AGER/CALML4/ITPR3	3.38295994364307
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	21/2076	48/9376	1.97591522157996	HMGCS1/ALDH2/HIBCH/ACADM/ALDH9A1/PCCA/ALDH3A2/HADHB/HADH/HIBADH/DBT/ACAT2/DLD/HSD17B10/ALDH6A1/MCCC1/ECHS1/ACAA2/AUH/ACAD8/MCEE	3.61473383758344
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2076	105/9376	1.63449857785118	NFKBIA/JUN/CYLD/PIK3CA/ARHGEF12/STAT1/NFATC1/BCL10/PLK3/PPP3R1/CASP1/MDM2/EGR3/NFKB1/PPP3CC/STAT2/KRAS/PPP3CA/MAPK8/NRAS/CLEC4M/IKBKB/AKT1/ITPR1/CALM1/PTPN11/MAPK1/PYCARD/MAPK9/PPP3CB/PIK3R3/RELA/MALT1/IL12A/CASP8/MAPK12/CALML4/ITPR3	3.48658208848485
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	45/2076	130/9376	1.56336149399733	NFKBIA/FOS/SOS2/ATF2/JUN/GNAI3/GNB4/TGFBR2/PIK3CA/SOS1/EDNRB/ADCY4/PRKCA/GNAS/PLCB1/NFKB1/COL4A1/CREB5/KRAS/PRKCZ/GNG12/MAPK8/CREB1/ARRB1/NRAS/PLCB4/SHC1/GNG5/GNG11/AKT1/PRKACB/MAPK1/GNGT2/MAPK9/MAP2K2/PIK3R3/RELA/MAP2K4/GNG10/MAP2K1/ADCY6/MAPK12/GNAI2/SHC2/CREB3L4	3.44921108993206
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/2076	71/9376	1.78110667860729	FOS/SOS2/PIK3CA/SOS1/STAT1/SOCS2/SOCS4/NFKB1/KRAS/MAPK8/STAT3/NRAS/SOCS1/SHC1/SOCS6/AKT1/MAPK1/GSK3B/MAPK9/MAP2K2/PIK3R3/RELA/JAK2/MAP2K1/MAPK12/SHC2/ESR2/SOCS3	3.52305334733937
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	71/2076	227/9376	1.41261151146308	NFKBIA/GSTM3/FOS/SOS2/SDHD/SOD2/PRKD3/MGST2/HGF/JUN/PIK3CA/SOS1/NDUFB5/EPHX4/PTEN/AHR/PTK2/NDUFC2/NDUFB3/VDAC3/ACP1/NFKB1/HIF1A/KRAS/EPHX1/NDUFV2/MT-ND6/MAPK8/BRAF/VDAC2/NDUFA5/UQCRC2/NRAS/SOD1/IKBKB/ATP5F1C/NDUFA8/VDAC1/NDUFS4/AKT1/NQO1/NDUFA7/UQCRFS1/NDUFC1/SLC25A5/PTPN11/NDUFB8/MAPK1/NDUFB4/GSTA4/MAPK9/COX7A2L/MAP2K2/UQCRH/NDUFB6/SDHB/NDUFA6/AKR1C3/PIK3R3/RELA/GSTO1/MAP2K4/NDUFA9/SDHC/CAT/MAP2K1/MAPK12/COX7B/EPHX2/CBR1/MGST3	3.35587161488123
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	34/2076	93/9376	1.65114881803302	SOS2/CAMK2D/JUN/SOS1/ADCY4/PRKCA/GNAS/CDC42/PLCB1/PLA2G4C/MAP3K1/KRAS/MAPK7/MAP3K4/ELK1/MAPK8/MAP2K3/MAP2K6/NRAS/HBEGF/PLCB4/ITPR1/CALM1/PRKACB/MAPK1/MAPK9/MAP2K2/MAP2K4/MAP2K1/ADCY6/MAPK12/PLA2G4A/CALML4/ITPR3	3.3652353193283
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	42/2076	122/9376	1.55481853501374	TBC1D4/PIK3CA/KAT2B/STAT1/PRKCA/SIN3A/ITGAV/MED13/PLCB1/MDM2/CTNNB1/NOTCH1/ATP2A2/MED30/HIF1A/KRAS/MED4/MYC/EP300/NRAS/PLCB4/MED17/KAT2A/THRA/HDAC1/PLCE1/NCOA1/NCOA3/AKT1/PRKACB/MAPK1/GSK3B/MED13L/ATP1A1/MAP2K2/MED14/MED12/PIK3R3/RHEB/MAP2K1/SLC16A2/MTOR	3.28930398928484
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	73/2076	238/9376	1.38527549748223	EFNA5/TBK1/RASGRP3/SOS2/IGF1/HGF/GNB4/GAB1/PIK3CA/RAPGEF5/SOS1/PRKCA/PGF/CDC42/SHOC2/EFNA1/RALB/RAB5A/AFDN/FLT4/RALGAPA1/PLA2G4C/ARF6/RALGAPA2/NFKB1/KRAS/GNG12/ELK1/BRAP/MAPK8/TEK/EXOC2/ETS2/RAP1A/NRAS/RGL2/KDR/IKBKB/RASA2/ETS1/RASSF1/SHC1/RGL1/GNG5/GNG11/NF1/GRIN2B/PLCE1/AKT1/RAB5B/CALM1/PTPN11/REL/PRKACB/MAPK1/GNGT2/MAPK9/MAP2K2/EFNA4/CSF1/PIK3R3/RELA/GNG10/IGF1R/RALBP1/MAP2K1/PLA2G4A/SHC2/RASGRF2/KITLG/CALML4/RASGRF1/RAP1B	3.21049630405497
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	48/2076	144/9376	1.50545921644188	CXCL2/NFKBIA/CXCL1/TRA2A/TBK1/ALDH2/TRAF6/CASP3/LY96/SIRT1/CTNNB1/CXCL3/NFKB1/ACADM/TNFRSF1A/ALDH9A1/ADIPOR2/ALDH3A2/TRA2B/PRKAA1/MAPK8/ADIPOR1/MAP2K3/MAP2K6/CAMKK2/IRAK4/ACADVL/LPIN2/PRKAA2/IKBKB/RIPK1/CPT1A/CXCL8/AKT1/TICAM1/GSK3B/MAP3K7/MAPK9/MYD88/RELA/MAP2K4/IL12A/ACACB/FADD/ACACA/CASP8/MAPK12/TAB3	3.25954777356701
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	34/2076	94/9376	1.63358340507523	HSP90AB1/HSP90AA1/CXCL2/JUND/NFKBIA/CXCL1/TBK1/FOS/SRSF1/TRAF6/CASP3/JUN/HSP90B1/CXCL3/USP25/NFKB1/ELAVL1/MAPK7/TRAF3IP2/MAPK8/FOSB/IKBKB/FOSL1/CXCL8/TRAF2/MAPK1/GSK3B/MAP3K7/MAPK9/RELA/FADD/CASP8/MAPK12/TAB3	3.29218946697791
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	39/2076	112/9376	1.57266721717589	HSPA1A/HSPA1B/HSPA8/NFKBIA/BIRC2/HSPA6/TRAF6/CASP3/GNAI3/IFNGR1/LY96/IFNGR2/CYCS/STAT1/NFKB1/TNFRSF1A/TGFB3/LAMB1/MAPK8/MAP2K3/MAP2K6/IRAK4/STAT3/IKBKB/SOCS1/AKT1/MAPK1/MAP3K7/BIRC3/MAPK9/MYD88/RELA/JAK2/IL12A/CASP8/MAPK12/LAMC2/PIK3CG/GNAI2	3.25124684029433
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	97/2076	333/9376	1.31558147743119	MX1/MX2/CDKN1B/TBK1/SOS2/PARD6G/TBPL1/PPP2R5A/HEY1/ITGA2/EIF2AK2/HES1/CASP3/ISG15/MAML2/PIK3CA/SOS1/HES4/STAT1/GNAS/ITGAV/CDC42/PTEN/CDK2/PTK2/RB1/FZD6/ATP6V1C1/MDM2/PPP2R3C/CTNNB1/PPP2R2D/ITGA9/NOTCH1/NFKB1/RBL2/STAT2/TNFRSF1A/COL4A1/CREB5/OASL/KRAS/RELN/PRKCZ/PPP2R5C/LAMB1/PPP2CB/DLG1/IFNAR1/PPP2CA/ATM/CREB1/CCND3/EP300/UBE3A/PSEN1/NRAS/PPP2R2A/IKBKB/CSNK1A1/ATP6V0A1/APC/PPP2R1B/ATR/COL9A3/HDAC1/AKT1/HLA-F/TICAM1/PRKACB/MAPK1/GSK3B/MAML1/TLR3/PPP2R5E/MAP2K2/ITGA1/ATP6V1G1/DLG2/PIK3R3/RELA/RHEB/HES6/PRKCI/FADD/TBP/MFNG/PPP2R5B/FZD9/ATP6V1E2/MAP2K1/MTOR/CASP8/LLGL1/JAG1/LAMC2/CREB3L4	3.12690897557513
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	26/2076	67/9376	1.75262416242487	CAMK2D/PPP1CB/PRKCA/RPS6KA3/PPP1CC/PLCB1/PPP3R1/PPP3CC/KRAS/PPP3CA/BRAF/EP300/RAP1A/NRAS/PLCB4/GRIN2B/ITPR1/CALM1/PRKACB/MAPK1/MAP2K2/PPP3CB/MAP2K1/CALML4/RAP1B/ITPR3	3.2968707831178
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/2076	23/9376	2.35637094747424	MSH6/PMS2/MSH2/MSH3/RPA3/MLH3/PCNA/RFC4/RFC5/MLH1/RPA2/POLD4	3.473000233285
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	47/2076	142/9376	1.49485739097397	KLF2/HSP90AB1/HSP90AA1/DUSP1/GSTM3/FOS/MGST2/JUN/SDC4/HSP90B1/SUMO1/PIK3CA/ITGAV/PTK2/CTNNB1/NFKB1/TNFRSF1A/PRKCZ/MAPK7/PECAM1/MEF2C/PRKAA1/MAPK8/ARHGEF2/MAP2K6/SUMO2/CDH5/PRKAA2/KDR/IKBKB/SUMO4/AKT1/NQO1/CALM1/MAP2K5/GSTA4/MAP3K7/MAPK9/THBD/PIK3R3/RELA/GSTO1/MAP2K4/MAPK12/MGST3/CALML4/ACVR1	3.16859827101551
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	54/2076	170/9376	1.43461407684461	HSPA4/MPDZ/YBX3/PARD6G/JUN/MYH10/ARPC5L/MYL12A/RAB8A/WHAMM/CDC42/RAP2C/MYL12B/ARPC1B/ARHGAP17/AFDN/AMOT/MAP3K1/PPP2R2D/F11R/ARPC1A/RAB8B/CLDN5/PRKCZ/RAB13/PPP2CB/PRKAA1/DLG1/MAPK8/ARHGEF2/PPP2CA/NEDD4/ACTR3/PRKAA2/RAP1A/PPP2R2A/PPP2R1B/MSN/ACTR2/PRKACB/STK11/OCLN/RAPGEF2/MAPK9/DLG2/PCNA/CGNL1/TJP2/CLDN14/PRKCI/ACTR3C/CLDN12/LLGL1/TJP1	3.04951410774634
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	33/2076	93/9376	1.60258561750264	NFKBIA/CDKN1B/CKS2/BIRC2/GADD45A/ITGA2/TRAF6/CASP3/POLK/PIK3CA/CYCS/ITGAV/PTEN/CDK2/PTK2/RB1/NFKB1/COL4A1/MAX/LAMB1/MYC/IKBKB/SKP2/APAF1/AKT1/TRAF2/BIRC3/PIK3R3/RELA/RARB/GADD45B/DDB2/LAMC2	3.11425337308421
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	15/2076	33/9376	2.05289893151165	SEC22B/STX11/VAMP4/SNAP23/BET1/STX6/GOSR1/STX7/STX5/STX17/VTI1A/VAMP3/GOSR2/STX4/BNIP1	3.2310104541218
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/2076	30/9376	2.10764290301863	SDHD/SUCLA2/IDH1/ACO1/DLST/ACLY/PDHB/IDH3A/MDH1/DLD/FH/SDHB/SUCLG2/SDHC	3.24030126944827
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	23/2076	59/9376	1.76062179549982	SOS2/GADD45A/POLK/PIK3CA/SOS1/PTEN/CTNNB1/KRAS/ELK1/MYC/BRAF/NRAS/APC/CTNNA1/AKT1/MAPK1/GSK3B/MAP2K2/PIK3R3/MLH1/MAP2K1/GADD45B/DDB2	3.12532083147136
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	50/2076	157/9376	1.43833683099542	SAV1/ID1/PARD6G/BIRC2/PPP1CB/BBC3/SMAD1/TP53BP2/TGFBR2/STK3/SMAD4/BMP2/TEAD2/PPP1CC/FZD6/MOB1A/AMOT/BTRC/CTNNB1/PPP2R2D/YAP1/PRKCZ/TGFB3/SNAI2/PPP2CB/WWTR1/MYC/DLG1/YWHAG/PPP2CA/CCND3/YWHAQ/TEAD4/PPP2R2A/APC/RASSF1/PPP2R1B/LATS1/CTNNA1/CSNK1D/GSK3B/BIRC3/DLG2/ID2/YWHAH/CSNK1E/PRKCI/MOB1B/FZD9/LLGL1	2.95361418419428
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/2076	63/9376	1.72052481879071	GTF2H2/POLR2K/CUL4B/POLR2M/POLR2C/RAD23B/POLR2H/MNAT1/CCNH/POLR2F/GTF2H1/POLR2B/POLE3/RPA3/POLE4/ERCC3/PCNA/RFC4/GTF2H5/RFC5/POLR2D/RPA2/DDB2/POLD4	3.05993570227304
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	37/2076	109/9376	1.53308232133072	NFKBIA/TBK1/IRF7/FOS/TRAF6/JUN/LY96/PIK3CA/STAT1/MAP3K8/NFKB1/STAT2/TLR5/MAPK8/MAP2K3/IFNAR1/MAP2K6/IRAK4/IKBKB/RIPK1/CXCL8/AKT1/TICAM1/MAPK1/MAP3K7/TLR3/MAPK9/MAP2K2/MYD88/PIK3R3/RELA/MAP2K4/IL12A/FADD/MAP2K1/CASP8/MAPK12	2.98521647931521
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	26/2076	70/9376	1.67751169832095	NFKBIA/CD36/ACSL3/NFKB1/TNFRSF1A/ADIPOR2/PRKAA1/MAPK8/ADIPOR1/CAMKK2/NFKBIE/STAT3/PRKAA2/IKBKB/CPT1A/AKT1/TRAF2/ACSL4/PTPN11/STK11/MAPK9/RELA/JAK2/ACACB/MTOR/SOCS3	3.03404611231735
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	28/2076	77/9376	1.64231914520932	GADD45A/POLK/TGFBR2/PIK3CA/STAT1/SMAD4/CDC42/RALB/RB1/NFKB1/KRAS/TGFB3/MAPK8/BRAF/BRCA2/STAT3/IKBKB/AKT1/ARHGEF6/MAPK1/MAPK9/PIK3R3/RELA/RALBP1/MAP2K1/GADD45B/DDB2/MTOR	3.01797743583565
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	45/2076	139/9376	1.46213664906225	HSPA1A/HSPA1B/HSP90AB1/HSP90AA1/FKBP4/HSPA8/FOS/SOS2/ATF2/HSPA6/JUN/GNAI3/HSP90B1/PIK3CA/SOS1/ADCY4/GNAS/PLCB1/CREB5/SP1/KRAS/CREB1/NRAS/HBEGF/PLCB4/SHC1/NCOA1/NCOA3/AKT1/ITPR1/CALM1/PRKACB/MAPK1/FKBP5/MAP2K2/PIK3R3/MAP2K1/ADCY6/RARA/GNAI2/SHC2/ESR2/CALML4/CREB3L4/ITPR3	2.92718534383114
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	70/2076	235/9376	1.34530398065019	SOS2/ATF2/SDHD/ACSL3/KDM3A/SOS1/NDUFB5/ADCY4/KDM1A/RPS6KA3/GNAS/SMARCE1/NDUFC2/NDUFB3/COA5/CREB5/KRAS/NDUFV2/ARID1B/MT-ND6/PRKAA1/COX11/KDM3B/ACTL6A/MAP2K3/PPARG/CREB1/COA3/NDUFA5/PRKAA2/UQCRC2/NRAS/COA6/ATP5F1C/CPT1A/NDUFA8/SMARCC1/COX14/NDUFAF7/NDUFS4/NDUFA7/UQCRFS1/NDUFC1/ACSL4/NDUFB8/PRKACB/NDUFB4/SIRT6/COX10/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/NDUFAF1/RHEB/NDUFA9/NDUFAF4/SDHC/COX17/ADCY6/COX15/MTOR/MAPK12/COX7B/SMARCB1/COA4/ATP5MG/FRS2/CREB3L4	2.85875241371136
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/2076	34/9376	1.99251955117307	NFIL3/PER1/CUL1/BTRC/NR1D2/PRKAA1/CREB1/PRKAA2/FBXL3/SKP1/BHLHE40/CSNK1D/NPAS2/CLOCK/CSNK1E	3.09169383711247
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/2076	71/9376	1.65388477299248	CXCL2/NFKBIA/CXCL1/CASP3/JUN/ADAM17/CDC42/ATP6V1C1/F11R/CXCL3/NFKB1/MAPK8/ADAM10/IKBKB/ATP6V0A1/HBEGF/CXCL8/PTPN11/MAPK9/ATP6V1G1/RELA/MAP2K4/ATP6V1E2/NOD1/MAPK12/TJP1	2.94923984310677
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	18/2076	44/9376	1.84760903836048	DYNLL1/GNAS/RAB5A/DYNC1I1/CREB5/NSF/CREB1/DCTN6/RAB11A/RAB5B/PRKACB/DYNC1LI2/AVPR2/STX4/DYNC1H1/ADCY6/AQP3/CREB3L4	3.0051934597862
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	62/2076	205/9376	1.36592885003995	NFKBIA/CDKN1B/DDX3X/IRF7/ATF2/TBPL1/EIF2AK2/CASP3/JUN/SP100/PMAIP1/GTF2H2/PIK3CA/KAT2B/GTF2A2/CDC42/CDK2/RB1/GTF2B/VDAC3/GTF2A1/MDM2/EGR3/NFKB1/RBL2/CREB5/KRAS/DLG1/YWHAG/CREB1/POLB/CCND3/YWHAQ/EP300/UBE3A/STAT3/USP7/NRAS/RASA2/GTF2H1/KAT2A/HDAC1/SKP2/HDAC8/GTF2E1/TRAF2/HLA-F/REL/PRKACB/MAPK1/RANBP1/HNRNPK/YWHAH/DNAJA3/PIK3R3/RELA/CHEK1/IL6ST/HDAC5/TBP/CASP8/CREB3L4	2.82490025216548
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	45/2076	142/9376	1.43124643816657	JUND/NFKBIA/FOS/TRAF6/JUN/JUNB/IFNGR1/CYLD/TGFBR2/PIK3CA/IFNGR2/STAT1/NFATC1/PPP3R1/ATP2A2/NFKB1/PPP3CC/STAT2/TNFRSF1A/SIRPA/PPP3CA/MAPK8/PPARG/IFNAR1/MAP2K6/FOSB/CREB1/IKBKB/SOCS1/FOSL1/AKT1/ITPR1/TRAF2/MAPK1/MAP3K7/MAPK9/CSF1/PPP3CB/FYN/PIK3R3/RELA/MAP2K1/MAPK12/SOCS3/ITPR3	2.76129394706374
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/2076	76/9376	1.60450258594463	SOS2/IGF1/GADD45A/CAMK2D/POLK/PIK3CA/SOS1/PRKCA/PTEN/RB1/MDM2/KRAS/BRAF/NRAS/SHC1/AKT1/CALM1/MAPK1/MAP2K2/PIK3R3/IGF1R/MAP2K1/GADD45B/DDB2/MTOR/SHC2/CALML4	2.82163846858629
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	23/2076	62/9376	1.67543041829822	HSPA1A/HSPA1B/HSPA8/IGF1/HSPA6/SOD2/PIK3CA/SIRT1/ADCY4/ATG5/KRAS/PRKAA1/PRKAA2/NRAS/SOD1/HDAC1/AKT1/PRKACB/PIK3R3/IGF1R/CAT/ADCY6/MTOR	2.84541899288709
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	28/2076	80/9376	1.58073217726397	SOS2/IGF1/HGF/GAB1/GAS6/PIK3CA/SOS1/BCL2L11/PRKCA/PTEN/KRAS/BRAF/EIF4E/STAT3/NRAS/KDR/SHC1/NF1/AKT1/MAPK1/GSK3B/MAP2K2/PIK3R3/JAK2/IGF1R/MAP2K1/MTOR/SHC2	2.78170267937417
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	52/2076	170/9376	1.38148022214666	GSTM3/SOS2/GADD45A/MGST2/HGF/POLK/GAB1/TGFBR2/PIK3CA/SOS1/PRKCA/SMAD4/SMARCE1/PTEN/RB1/FZD6/ARID2/PHF10/CTNNB1/KRAS/ARID1B/FRAT2/ELK1/TGFB3/MYC/ACTL6A/BRAF/TXNRD1/BRD7/NRAS/CSNK1A1/APC/SHC1/SMARCC1/AKT1/NQO1/LRP6/MAPK1/GSK3B/GSTA4/MAP2K2/PIK3R3/GSTO1/IGF1R/FZD9/MAP2K1/GADD45B/DDB2/MTOR/SMARCB1/SHC2/MGST3	2.67669498353222
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	60/2076	201/9376	1.34817243263452	DDIT3/DDX5/CDKN1B/LMO2/BIRC2/IGF1/GADD45A/POLK/SMAD1/HHEX/NFKBIZ/TGFBR2/ELK4/SIN3A/CCNT2/CDKN2C/PTK2/KDM6A/MDM2/NFKB1/DUSP6/MAX/ETV6/SP1/MLF1/KLF3/ERG/MEF2C/MYC/PML/ATF1/PPARG/ATM/AFF1/MAF/EWSR1/JMJD1C/SLC45A3/PRCC/BMP2K/HDAC1/MYCN/TAF15/CXCL8/SS18L1/REL/BIRC3/TSPAN7/RUNX1T1/CDK9/ID2/RELA/BMI1/IGF1R/NSD2/DOT1L/GADD45B/DDB2/RARA/CCNT1	2.66089205531158
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	35/2076	106/9376	1.49125677100374	HSP90AB1/HSP90AA1/NFKBIA/CDKN1B/SOS2/IGF1/HSP90B1/PIK3CA/SOS1/PTEN/CDK2/RB1/MDM2/CTNNB1/NFKB1/CREB5/KRAS/ERG/NKX3-1/BRAF/CREB1/EP300/NRAS/IKBKB/AKT1/MAPK1/GSK3B/MAP2K2/PIK3R3/RELA/IGF1R/MAP2K1/FOLH1/MTOR/CREB3L4	2.7124359863617
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/2076	56/9376	1.69364161849711	MAN1A1/MGAT5/ALG13/STT3B/MGAT2/ALG6/TUSC3/DDOST/MAN2A1/ST6GAL1/OSTC/B4GALT1/SRD5A3/MGAT4C/RPN1/ALG10/DPM1/DAD1/ALG8/MAN1C1/ALG11	2.77625326925695
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	15/2076	36/9376	1.88182402055234	PRIM2/MCM3/POLE3/RPA3/POLE4/PRIM1/PCNA/RFC4/RFC5/RPA2/DNA2/MCM6/RNASEH1/POLA1/POLD4	2.82681651339399
Organismal Systems	Nervous system	hsa04730	Long-term depression	22/2076	60/9376	1.65600513808606	IGF1/GNAI3/PRKCA/GNAS/PLCB1/PLA2G4C/KRAS/PPP2CB/BRAF/PPP2CA/NRAS/PLCB4/GNA13/PPP2R1B/ITPR1/MAPK1/MAP2K2/IGF1R/MAP2K1/PLA2G4A/GNAI2/ITPR3	2.71835397800508
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	27/2076	78/9376	1.56336149399733	CASP7/FOS/TRAF6/CASP3/JUN/GNAI3/LY96/CFL2/IRF8/CASP1/NFKB1/MAPK8/IRAK4/CXCL8/CALM1/TICAM1/MAPK1/PYCARD/MAPK9/MYD88/RELA/IL12A/NOD1/C1R/MAPK12/GNAI2/CALML4	2.66426593880709
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	51/2076	168/9376	1.37104321497385	HSP90AB1/HSP90AA1/PPID/MLKL/BIRC2/EIF2AK2/CAMK2D/CHMP5/IFNGR1/CYLD/IFNGR2/STAT1/TRPM7/GLUD1/BID/VDAC3/CASP1/PLA2G4C/STAT2/CHMP7/TNFRSF1A/TNFRSF10B/CHMP4B/SPATA2/MAPK8/IFNAR1/VDAC2/STAT3/TNFSF10/SPATA2L/RIPK1/RBCK1/CHMP1B/VDAC1/TRAF2/SHARPIN/SLC25A5/TICAM1/CAPN2/CHMP2B/BIRC3/TLR3/PYCARD/MAPK9/AIFM1/JAK2/FADD/CASP8/PLA2G4A/USP21/PPIA	2.58782177344243
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	21/2076	57/9376	1.66392860764628	HSD17B4/ACSL3/SCP2/ELOVL5/ACADM/ACADVL/HADHB/ELOVL1/HADH/HACD2/CPT1A/ACAT2/ACSL4/HSD17B12/HACD3/CBR4/ECHS1/ACAA2/PPT2/ACACA/MCAT	2.68109397571943
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/2076	75/9376	1.56567758509955	GSTM3/BIRC2/MGST2/CASP3/BBC3/PMAIP1/PIK3CA/CYCS/TOP2B/MSH6/BID/MDM2/ATM/MSH2/MSH3/APAF1/AKT1/MAPK1/GSTA4/BIRC3/PIK3R3/GSTO1/FADD/MLH1/CASP8/MGST3	2.62284521881552
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	29/2076	86/9376	1.52296455616794	CDKN1B/NCK1/SOS2/CAMK2D/JUN/GAB1/PIK3CA/SOS1/PRKCA/PTK2/KRAS/ELK1/MYC/MAPK8/BRAF/NRAS/NCK2/HBEGF/SHC1/AKT1/MAPK1/GSK3B/MAPK9/MAP2K2/PIK3R3/MAP2K4/MAP2K1/MTOR/SHC2	2.59807394148644
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	15/2076	37/9376	1.83096391188877	GADD45A/POLK/CTNNB1/KRAS/TFG/MYC/BRAF/PPARG/CCDC6/NRAS/MAPK1/MAP2K2/MAP2K1/GADD45B/DDB2	2.70066502533466
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	86/2076	308/9376	1.26106648650001	PSMA2/TBPL1/SDHD/SOD2/CASP3/BBC3/PSMD12/POLR2K/NDUFB5/NRBF2/CYCS/SIN3A/NDUFC2/PLCB1/NDUFB3/VDAC3/IFT57/PSMC6/CREB5/SP1/NDUFV2/POLR2C/ATG101/MT-ND6/ACTR10/MAPK8/PSMB2/PPARG/PIK3R4/PSMD11/CREB1/PIK3C3/POLR2H/WIPI2/PSMA3/EP300/VDAC2/NDUFA5/CLTC/DCTN6/UQCRC2/PSMA5/SOD1/PSMC2/ATP5F1C/POLR2F/PLCB4/POLR2B/ERN1/NDUFA8/PSMA1/HDAC1/VDAC1/APAF1/GRIN2B/NDUFS4/ITPR1/TRAF2/NDUFA7/UQCRFS1/NDUFC1/SLC25A5/NDUFB8/TUBB2A/NDUFB4/ATG2B/MAPK9/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/TFAM/PSMB5/HIP1/NDUFA9/TAF4/SDHC/POLR2D/TBP/CLTA/MTOR/CASP8/COX7B/AP2M1/CREB3L4	2.48432614339484
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	54/2076	181/9376	1.34742758598665	HSPD1/NFYB/TRAF6/RIPK2/CAMK2D/CASP3/IFNGR1/ARHGEF12/MRC1/IFNGR2/CYCS/STAT1/CASP10/BCL10/RAB5A/PLK3/BID/PPP3R1/CEBPG/NFKB1/PPP3CC/TNFRSF1A/LAMP2/PPP3CA/NFYA/TGFB3/MAPK8/CREB1/PIK3C3/HSPA9/IRAK4/EP300/CLEC4M/IRAK2/ATP6V0A1/APAF1/AKT1/RAB5B/NFYC/CALM1/RAB7A/MAPK1/MAPK9/PPP3CB/MYD88/RELA/MALT1/JAK2/IL12A/FADD/CASP8/MAPK12/RFX5/CALML4	2.51689792164127
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	76/2076	268/9376	1.28076381100279	HSPA5/DUSP1/DDIT3/PSMA2/XBP1/SDHD/CAMK2D/CASP3/GNAI3/PSMD12/NDUFB5/UBE2L6/CYCS/EIF2S1/GNAS/SLC39A1/NDUFC2/NDUFB3/VDAC3/SNCAIP/SLC39A14/MFN1/PSMC6/UBE2J1/UBE2J2/NDUFV2/UBE2G1/MT-ND6/MAPK8/PSMB2/PSMD11/PSMA3/VDAC2/NDUFA5/UQCRC2/PSMA5/SOD1/PSMC2/ATP5F1C/SNCA/ERN1/NDUFA8/PSMA1/VDAC1/APAF1/NDUFS4/ITPR1/EIF2AK3/NDUFA7/UQCRFS1/NDUFC1/CALM1/SLC25A5/NDUFB8/PRKACB/TUBB2A/NDUFB4/UBC/MAPK9/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/PINK1/HTRA2/PSMB5/UBB/NDUFA9/SDHC/PARK7/COX7B/GNAI2/CALML4/UBA7/ITPR3	2.48676586620195
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	35/2076	109/9376	1.45021300666419	NFKBIA/CD36/TBC1D4/PPP1CB/PIK3CA/RPS6KA3/OGT/PTEN/PPP1CC/NFKB1/TNFRSF1A/CREB5/PRKCZ/PRKAA1/MAPK8/MLXIP/CREB1/NR1H2/STAT3/PRKAA2/IKBKB/CPT1A/AKT1/PTPN11/GSK3B/SLC27A3/MAPK9/PPP1R3D/PIK3R3/RELA/ACACB/CRTC2/MTOR/SOCS3/CREB3L4	2.52115523797723
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	37/2076	117/9376	1.42825617970127	PHF6/SMARCE1/BRD8/ARID2/EPC2/PHF10/MBD2/EPC1/CDK2AP2/CDK2AP1/MORF4L2/YEATS4/BCL7C/ING3/ARID1B/TRRAP/ACTL6A/ACTR6/UCHL5/MTA2/MEAF6/BRD7/INO80D/POLE3/SMARCC1/HDAC1/CHRAC1/SS18L1/SMARCA5/DPF2/MTA3/BCL7B/INO80C/MORF4L1/BICRA/SMARCB1/ACTR5	2.48572116430962
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	25/2076	73/9376	1.54670467442658	MX1/MX2/XPO1/TRIM5/KAT2B/CCNT2/MDFIC/BST2/NUP153/CPSF6/CHMP4B/TSG101/PDCD6IP/EP300/AFF4/KAT2A/RAN/SERINC3/SERINC5/NELFCD/CDK9/SAMHD1/SMARCB1/CCNT1/PPIA	2.50057905692843
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	38/2076	122/9376	1.40674057929815	CD36/IGF1/PPP2R5A/PIK3CA/RAB8A/SIRT1/RAB10/PPP2R3C/PPP2R2D/ELAVL1/CREB5/HMGCR/ADIPOR2/PPP2R5C/PPP2CB/PRKAA1/ADIPOR1/PPARG/PPP2CA/CAMKK2/CREB1/PRKAA2/PPP2R2A/CPT1A/PPP2R1B/AKT1/STK11/MAP3K7/PPP2R5E/PIK3R3/RHEB/IGF1R/ACACB/CRTC2/PPP2R5B/ACACA/MTOR/CREB3L4	2.41140720011505
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	42/2076	138/9376	1.37454971935997	MKNK2/SOS2/PPP1CB/PIK3CA/SOS1/SOCS2/SOCS4/PPP1CC/KRAS/PRKCZ/PRKAR1A/ELK1/PRKAA1/MAPK8/BRAF/EIF4E/PRKAA2/NRAS/IKBKB/SOCS1/SHC1/PRKAR1B/AKT1/CALM1/PRKACB/MAPK1/GSK3B/MAPK9/MAP2K2/PPP1R3D/PIK3R3/RHEB/HK1/PRKCI/ACACB/FLOT1/MAP2K1/ACACA/MTOR/SHC2/SOCS3/CALML4	2.3637303034868
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	13/2076	32/9376	1.83477842003854	SUCLA2/HIBCH/ECHDC1/PCCA/DBT/DLD/SUCLG2/ALDH6A1/ECHS1/ACSS2/ACACB/ACACA/MCEE	2.52242156419301
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	12/2076	29/9376	1.86884592385888	SAV1/STK3/TEAD2/MOB1A/YAP1/FAT4/WWTR1/TEAD4/RASSF1/LATS1/CSNK1E/MOB1B	2.49886922399772
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	70/2076	250/9376	1.26458574181118	VPS26A/VPS13C/AP1G1/LAPTM4B/LAMTOR3/SCARB2/AP3M1/VPS13A/ATP6V1C1/OSTM1/OSBP/NCOA7/DTNBP1/M6PR/STX17/GALC/NPC1/LAMP2/HYAL2/CLN8/CLN5/SLC15A3/AP4M1/BLOC1S2/PLEKHM1/LAMP3/AP3S1/AP1S1/ARL8B/CLTC/SNAPIN/ATP6V0A1/LIPA/NEU1/CD164/RRAGB/ROGDI/CTBS/CTSH/GNPTG/RAB7A/SLC36A4/GNPTAB/TTI1/TLR3/VPS29/ATP6V1G1/BLOC1S6/AP5M1/PIKFYVE/LAPTM4A/AP4S1/PLA2G15/GGA2/VPS11/BLOC1S4/CLTA/PPT2/SLC38A9/GLA/ATP6V1E2/LAMTOR5/VPS16/BLOC1S3/MTOR/RRAGA/AP4B1/VPS26B/AP2M1/OSBPL3	2.26117456568157
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	33/2076	105/9376	1.41943297550234	CXCL2/NFKBIA/CXCL1/BIRC2/GADD45A/TRAF6/LY96/CYLD/TRIM25/BCL10/CXCL3/NFKB1/CSNK2A2/TNFRSF1A/CARD10/ATM/IRAK4/IKBKB/RIPK1/CXCL8/TRAF2/CSNK2A1/TICAM1/UBE2I/MAP3K7/BIRC3/ERC1/MYD88/RELA/MALT1/GADD45B/TAB3/CCL21	2.30479239947069
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	76/2076	275/9376	1.24816255035908	HSPA1A/HSPA1B/HSPA5/HSPA8/DDIT3/STIP1/PSMA2/ATF2/HSPA6/SDHD/CASP3/PSMD12/PIK3CA/NDUFB5/CYCS/EIF2S1/NDUFC2/NDUFB3/PPP3R1/VDAC3/NOTCH1/PSMC6/PPP3CC/CSNK2A2/CREB5/NDUFV2/PPP3CA/MT-ND6/MAPK8/PSMB2/PSMD11/CREB1/PSMA3/NCAM1/VDAC2/NDUFA5/UQCRC2/PSMA5/SOD1/PSMC2/ATP5F1C/NDUFA8/PSMA1/VDAC1/APAF1/GRIN2B/NDUFS4/ITPR1/EIF2AK3/NDUFA7/UQCRFS1/CSNK2A1/NDUFC1/SLC25A5/NDUFB8/PRKACB/MAPK1/TUBB2A/NDUFB4/GSK3B/MAPK9/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/PPP3CB/FYN/PIK3R3/PSMB5/NDUFA9/SDHC/MAPK12/COX7B/CREB3L4/ITPR3	2.22738820824374
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	23/2076	68/9376	1.52759832256602	SOS2/PIK3CA/SOS1/NFKB1/DUSP6/KRAS/MYC/PML/BRAF/STAT3/NRAS/IKBKB/AKT1/MAPK1/PPARD/RUNX1T1/MAP2K2/PIK3R3/RELA/PIM2/MAP2K1/MTOR/RARA	2.32845343842827
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	10/2076	23/9376	1.96364245622853	HMGCS1/IDI1/GGPS1/NUS1/FNTA/HMGCR/PDSS2/ACAT2/ZMPSTE24/FNTB	2.46741533465983
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	44/2076	148/9376	1.34270686871843	FOS/SOS2/IGF1/GADD45A/HEY1/HES1/JUN/POLK/DLL4/PIK3CA/SOS1/PTEN/RB1/FZD6/FLT4/CTNNB1/NOTCH1/SP1/KRAS/FRAT2/MYC/BRAF/BRCA2/NRAS/CSNK1A1/APC/SHC1/NCOA1/NCOA3/AKT1/LRP6/MAPK1/GSK3B/MAP2K2/PIK3R3/IGF1R/FZD9/MAP2K1/GADD45B/DDB2/MTOR/JAG1/SHC2/ESR2	2.24097884294528
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	27/2076	83/9376	1.46918309074448	MLKL/NFKBIA/CASP7/TBK1/IRF7/CASP3/POLR1D/POLR2K/POLR3K/CASP1/G3BP1/NFKB1/ADAR/CGAS/ZCCHC3/POLR2H/IKBKB/IFI16/POLR2F/RIPK1/PYCARD/POLR3F/RELA/SAMHD1/FADD/CASP8/POLR3A	2.28950350217036
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	34/2076	110/9376	1.39597127342792	ID1/SMAD9/ID3/SMAD1/TGFBR2/LEMD3/SKIL/ZFYVE16/SMAD4/SIN3A/BMP2/TGIF1/SMAD5/CUL1/ZFYVE9/SP1/TGFB3/PPP2CB/MYC/PPP2CA/EP300/SKP1/PPP2R1B/HDAC1/TFDP1/MAPK1/ACVR1B/ID2/NEO1/SMURF2/HFE/SMURF1/TGIF2/ACVR1	2.22767462353511
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	34/2076	110/9376	1.39597127342792	HSP90AB1/HSP90AA1/CDC25B/IGF1/GNAI3/PIK3CA/ADCY4/RPS6KA3/CDK2/CDC23/CPEB2/ANAPC10/CDC26/KRAS/CDC16/MAPK8/BRAF/ANAPC7/CDC27/ANAPC16/AKT1/PRKACB/MAPK1/MAPK9/ANAPC1/PIK3R3/SPDYA/IGF1R/MAP2K1/ADCY6/MAPK12/ANAPC4/GNAI2/CCNB1	2.22767462353511
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	58/2076	205/9376	1.27780440810188	CD36/TBC1D4/SDHD/CAMK2D/PPP1CB/TGFBR2/PIK3CA/NDUFB5/PRKCA/PTEN/PPP1CC/MPC2/NDUFC2/PLCB1/NDUFB3/VDAC3/ATP2A2/NFKB1/SP1/PRKCZ/NDUFV2/TGFB3/MT-ND6/MAPK8/VDAC2/NDUFA5/MPC1/UQCRC2/PDHB/ATP5F1C/PLCB4/NDUFA8/VDAC1/NDUFS4/AKT1/NDUFA7/UQCRFS1/NDUFC1/PDK4/SLC25A5/NDUFB8/NDUFB4/GSK3B/MAPK9/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/GSR/PIK3R3/RELA/NDUFA9/SDHC/MTOR/MAPK12/COX7B/AGER	2.14459653130391
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/2076	62/9376	1.52974081670707	DTX3L/HEY1/HES1/NUMB/ADAM17/MAML2/DLL4/KAT2B/TLE4/NRARP/TLE1/NOTCH1/EP300/PSEN1/KAT2A/HDAC1/MAML1/ATXN1L/MFNG/CTBP1/JAG1	2.23166523202141
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	51/2076	178/9376	1.29401831525622	CACYBP/SIAH1/CAMK2D/JUN/CBY1/SIRT1/RYK/PRKCA/SMAD4/TLE4/NFATC1/CUL1/FZD6/PLCB1/PPP3R1/TLE1/BTRC/CTNNB1/PPP3CC/CSNK2A2/TBL1XR1/PPP3CA/FRAT2/MYC/MAPK8/SFRP1/CCND3/EP300/PSEN1/SKP1/CSNK1A1/APC/PLCB4/FOSL1/CCDC88C/CHD8/SENP2/CSNK2A1/LRP6/PRKACB/GSK3B/MAP3K7/PPARD/MAPK9/INVS/PPP3CB/CSNK1E/CCAR2/FZD9/CTBP1/LZTS2	2.11191077506359
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	15/2076	41/9376	1.65233328633864	UIMC1/NBN/BARD1/MRE11/TOPBP1/ATM/BRCA2/RAD50/RPA3/RAD51C/RAD51B/BABAM1/RPA2/RAD52/POLD4	2.23224669995101
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	31/2076	101/9376	1.38621492207024	CDKN1B/CASP3/JUN/TGFBR2/PIK3CA/STAT1/PRKCA/SMAD4/CDC42/NFATC1/PLCB1/NFKB1/COL4A1/KRAS/PRKCZ/TGFB3/MAPK8/STAT3/NRAS/PLCB4/PLCE1/CXCL8/AKT1/MAPK1/MAPK9/THBD/PIK3R3/RELA/JAK2/MAPK12/AGER	2.08099319456757
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/2076	56/9376	1.53234241673548	EFCAB7/SPOP/CUL3/EVC2/CUL1/CSNK1G3/EVC/BTRC/ARRB1/MOSMO/CSNK1A1/CSNK1D/PRKACB/GSK3B/CSNK1E/SMURF2/SPOPL/SMURF1/CSNK1G2	2.13066421537418
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	59/2076	212/9376	1.25691642127458	ID1/EFNA5/VAV3/RASGRP3/PARD6G/IGF1/PRKD3/HGF/GNAI3/PIK3CA/RAPGEF5/ADCY4/PRKCA/GNAS/PGF/CDC42/EFNA1/RALB/AFDN/FLT4/PLCB1/CTNNB1/KRAS/PRKCZ/CTNND1/BRAF/MAP2K3/TEK/MAP2K6/ARAP3/RAP1A/NRAS/FARP2/KDR/PLCB4/BCAR1/GRIN2B/PLCE1/AKT1/SIPA1/CALM1/MAPK1/RAPGEF2/MAP2K2/EFNA4/CSF1/PIK3R3/DOCK4/IGF1R/PRKCI/MAP2K1/ADCY6/MAPK12/RAPGEF4/GNAI2/KITLG/CALML4/SIPA1L3/RAP1B	2.01769322997738
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	20/2076	60/9376	1.50545921644188	PIK3CA/PRKCA/CDC42/PTK2/PPP3R1/PLA2G4C/PPP3CC/KRAS/PPP3CA/NRAS/KDR/AKT1/MAPK1/MAP2K2/PPP3CB/PIK3R3/MAP2K1/MAPK12/PLA2G4A/SHC2	2.09452181387311
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/2076	28/9376	1.77429121937792	ELOVL5/HADHB/ELOVL1/HADH/HACD2/HSD17B12/HACD3/ECHS1/ACAA2/PPT2/ACOT2	2.18807337134906
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	18/2076	54/9376	1.50545921644188	HES1/WDR48/POLK/FANCL/BRCA2/PMS2/ATR/RPA3/RAD51C/RMI1/FANCA/FANCF/FAN1/FANCC/UBE2T/MLH1/RPA2/FANCM	1.98639829205693
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	22/2076	69/9376	1.44000446790092	VAV3/SOS2/PIK3CA/SOS1/PRKCA/PLA2G4C/KRAS/MAPK8/MAP2K3/MAP2K6/NRAS/AKT1/MAPK1/MAPK9/MAP2K2/FYN/PIK3R3/MAP2K4/MAP2K1/MAPK12/PLA2G4A/FCER1A	1.95620631956198
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	22/2076	69/9376	1.44000446790092	FOS/ATF2/CAMK2D/PPP1CB/JUN/SIRT1/PRKCA/GNAS/PPP1CC/PPP3R1/PPP3CC/CREB5/PPP3CA/FOSB/CREB1/HDAC1/GRIN2B/CALM1/PRKACB/PPP3CB/CALML4/CREB3L4	1.95620631956198
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/2076	85/9376	1.38148022214666	CMPK2/NTPCR/NT5C3A/PNP/GMPR2/NT5C2/DCK/NT5E/CMPK1/AK6/GMPS/DTYMK/NME7/DCTPP1/LACC1/DUT/NT5C3B/HPRT1/RRM2B/CANT1/DGUOK/AK2/AK1/CTPS2/ADSL/TYMS	1.88403142504513
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	41/2076	144/9376	1.28591308071077	KLF4/ID1/IGF1/LIF/SMAD9/ID3/SMAD1/HOXD1/PIK3CA/SMARCAD1/SKIL/SMAD4/SMAD5/FZD6/KAT6A/CTNNB1/KRAS/MYC/PCGF5/PCGF3/STAT3/NRAS/APC/AKT1/MAPK1/GSK3B/MAP2K2/ACVR1B/ID2/PIK3R3/BMI1/SETDB1/IL6ST/JAK2/HOXA1/IGF1R/ZFHX3/FZD9/MAP2K1/MAPK12/ACVR1	1.84376368132094
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	42/2076	149/9376	1.27307289444078	SOS2/GAB1/PIK3CA/SOS1/ADCY4/PRKCA/GNAS/RALB/PLCB1/LPAR6/PLA2G4C/ARF6/AGPAT5/KRAS/NRAS/DGKE/CYTH2/PLCB4/SHC1/GNA13/CXCL8/ARF1/AKT1/PTPN11/MAPK1/MAP2K2/AGPAT4/PIP5K1A/FYN/PIK3R3/RHEB/DGKZ/AVPR2/MAP2K1/ADCY6/MTOR/PLA2G4A/RAPGEF4/PIK3CG/SHC2/FCER1A/KITLG	1.79175799202984
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/2076	10/9376	2.25818882466281	SQOR/MPST/ETHE1/BPNT1/PAPSS1	2.12278802692842
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	43/2076	154/9376	1.26106648650001	GCH1/CMPK2/ALDH2/SPR/RFK/MOCS2/NADK2/DHODH/CPOX/PTS/CMPK1/AK6/ALAS1/NMNAT1/ALDH3A2/RDH11/MTHFD2L/NME7/AFMID/PANK3/MAT2B/LIPT1/NQO1/PNPO/DLD/MAT2A/COX10/COQ2/GCLM/UGP2/ALAD/NFS1/NADK/DHFR/COQ5/COX15/AK2/PHOSPHO2/AK1/CTPS2/TPK1/IDO1/ADSL	1.74195450623555
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	55/2076	203/9376	1.22364911681236	VAV3/SOS2/BIRC2/IGF1/ITGA2/PPP1CB/HGF/JUN/PIK3CA/MYL12A/SOS1/PRKCA/PGF/ITGAV/CDC42/DOCK1/PTEN/PTK2/PPP1CC/MYL12B/FLT4/CTNNB1/EMP2/ITGA9/COL4A1/RELN/ELK1/LAMB1/MAPK8/BRAF/CCND3/RAP1A/KDR/BCAR1/SHC1/COL9A3/AKT1/ARHGAP5/CAPN2/MAPK1/GSK3B/BIRC3/MAPK9/ITGA1/PARVB/PIP5K1A/FYN/PIK3R3/IGF1R/MAP2K1/LAMC2/SHC2/RASGRF1/RAP1B/MYLK	1.71789807256273
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/2076	34/9376	1.59401564093846	POLR1D/POLR2K/CRCP/POLR2M/POLR3K/POLR2C/POLR2H/POLR2F/POLR2B/POLR3F/POLR2D/POLR3A	1.85035598952911
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	27/2076	91/9376	1.340024137712	VAV3/NFKBIA/RASGRP3/FOS/SOS2/JUN/PIK3CA/SOS1/NFATC1/BCL10/PPP3R1/NFKB1/PPP3CC/KRAS/PPP3CA/NFKBIE/NRAS/IKBKB/AKT1/MAPK1/GSK3B/MAP2K2/PPP3CB/PIK3R3/RELA/MALT1/MAP2K1	1.73811045844063
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	29/2076	99/9376	1.32297931141862	FOS/SOS2/JUN/PIK3CA/SOS1/PRKCA/PLA2G4C/CHKA/HIF1A/SP1/CHPT1/KRAS/WASF3/MAPK8/LYPLA1/NRAS/DGKE/AKT1/MAPK1/MAPK9/MAP2K2/PIP5K1A/PIK3R3/RHEB/DGKZ/MAP2K1/MTOR/WASF1/PLA2G4A	1.72276645205341
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	31/2076	107/9376	1.30848324419714	ATF2/CAMK2D/SIRT1/GNAS/PPP4R3B/PLCB1/PPP3R1/PPP3CC/CREB5/SIK1/PPP3CA/PPP4R3A/PRKAA1/CREB1/EP300/PRKAA2/PDHB/PLCB4/CPT1A/PPP4C/AKT1/ITPR1/CALM1/PRKACB/PPP3CB/ACACB/CRTC2/ACACA/CALML4/CREB3L4/ITPR3	1.71137392254922
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2076	38/9376	1.54507656424298	SIRT1/PNP/NT5C2/NADK2/NT5E/NMNAT1/SIRT2/NNT/SIRT6/SIRT5/NADK/NNMT/NUDT12	1.79539601137034
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/2076	31/9376	1.60258561750264	ACO1/PCCA/AFMID/MDH1/ACAT2/DLD/ACSS2/PGP/CAT/MCEE/GLYCTK	1.79204057450163
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	39/2076	140/9376	1.25813377374071	KLF2/GNAI3/GNB4/MAP1LC3B/ADCY4/SMAD4/PLCB1/KRAS/GNG12/MEF2C/PRKAA1/PIK3R4/PIK3C3/PRKAA2/NRAS/PLCB4/GNA13/GNG5/GNG11/AKT1/ITPR1/CALM1/PRKACB/MAPK1/GNGT2/MAP2K2/TFAM/GNG10/HDAC5/MAP2K1/ADCY6/MEF2D/MTOR/JAG1/PIK3CG/GNAI2/CALML4/ITPR3/MYLK	1.6409855960015
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/2076	116/9376	1.28483157265298	SDHD/SUCLA2/IDH1/GLUD1/HIBCH/ACO1/RPE/PCCA/DLST/GOT2/PDHB/IDH3A/MDH1/ME2/PSPH/ACAT2/ESD/DLD/FH/PRPS1/RPIA/SDHB/SUCLG2/ALDH6A1/HK1/ECHS1/ACSS2/SDHC/PGP/ADPGK/CAT/MCEE/GLYCTK	1.64607459333679
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	27/2076	93/9376	1.31120641432034	NFKBIA/FOS/JUN/MAML2/IFNGR1/DLL4/IFNGR2/STAT1/NFATC1/PPP3R1/NOTCH1/NFKB1/PPP3CC/PPP3CA/MAPK8/NFKBIE/MAF/IKBKB/MAPK1/MAML1/MAPK9/PPP3CB/RELA/JAK2/IL12A/MAPK12/JAG1	1.60836169561966
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/2076	43/9376	1.47044853698974	ALDH2/ACSL3/ACADM/ALDH9A1/ALDH3A2/ACADVL/HADHB/HADH/CPT1A/ECI2/ACAT2/ACSL4/ECHS1/ACAA2	1.64882134075311
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	15/2076	47/9376	1.4413971221252	ALDH2/ACYP1/ALDH9A1/ALDH3A2/GLO1/PDHB/MDH1/ME2/ACAT2/HAGH/DLD/FH/ACSS2/ACACB/ACACA	1.61770289399471
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/2076	78/9376	1.33175238377551	ARPC5L/GAB1/PIK3CA/CDC42/DOCK1/PTK2/WASL/ARPC1B/CTNNB1/ARPC1A/ELMO1/CD2AP/ACTR3/CLTC/BCAR1/SHC1/CTNNA1/ACTR2/PIK3R3/CLTA/ACTR3C/WASF1/SHC2	1.56893324380335
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/2076	18/9376	1.75636908584885	LMBRD1/MMADHC/ABCD4/ZNF143/THAP11/PRDX1/MMAA	1.7128383770716
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	49/2076	184/9376	1.20273100443998	EFNA5/NCK1/PARD6G/SEMA6A/CAMK2D/GNAI3/SRGAP2/PIK3CA/MYL12A/CFL2/RYK/ARHGEF12/PRKCA/CDC42/EFNA1/PTK2/MYL12B/PPP3R1/PPP3CC/LIMK2/SSH2/KRAS/PRKCZ/PPP3CA/NRAS/EPHB4/SEMA3D/NCK2/SEMA3A/TRPC6/SEMA4D/SEMA6C/EFNB2/NTN1/PTPN11/MAPK1/GSK3B/LRIG2/EFNA4/NEO1/PPP3CB/FYN/PIK3R3/SSH1/SEMA4F/SEMA3F/SEMA3G/EPHB1/GNAI2	1.48102353002491
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	32/2076	115/9376	1.25673117198626	FOS/CAMK2D/GNAI3/GNB4/PIK3CA/ADCY4/PRKCA/PLCB1/CREB5/KRAS/GNG12/CREB1/NRAS/PLCB4/GNG5/GNG11/AKT1/ITPR1/PRKACB/MAPK1/GNGT2/ACHE/FYN/PIK3R3/GNG10/JAK2/MAP2K1/ADCY6/PIK3CG/GNAI2/CREB3L4/ITPR3	1.47719035782002
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	32/2076	115/9376	1.25673117198626	JUND/FOS/ATF2/GNAI3/ADCY4/PRKCA/GNAS/PLCB1/ARHGEF11/PDE4B/MMP16/CREB5/SP1/MEF2C/BRAF/CREB1/ARRB1/HBEGF/PLCB4/GNA13/ITPR1/LRP6/PRKACB/MAPK1/STK39/WNK3/MAP2K1/ADCY6/MEF2D/GNAI2/CREB3L4/ITPR3	1.47719035782002
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/2076	44/9376	1.43702925205815	MAN1A1/ALG13/STT3B/MGAT2/TUSC3/DDOST/MAN2A1/OSTC/B4GALT1/MGAT4C/RPN1/DAD1/MAN1C1/ALG11	1.54948495188398
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	91/2076	362/9376	1.13533250300727	HSP90AB1/HSP90AA1/EFNA5/CDKN1B/IL7/SOS2/ATF2/IGF1/PPP2R5A/ITGA2/HGF/MCL1/HSP90B1/GNB4/PIK3CA/SOS1/BCL2L11/PRKCA/PGF/ITGAV/PTEN/EFNA1/CDK2/PTK2/FLT4/SGK3/LPAR6/MDM2/PPP2R3C/PPP2R2D/ITGA9/NFKB1/RBL2/COL4A1/CREB5/KRAS/RELN/GNG12/PPP2R5C/LAMB1/PPP2CB/PRKAA1/MYC/YWHAG/IFNAR1/TEK/PPP2CA/CREB1/EIF4E/CCND3/YWHAQ/PRKAA2/NRAS/PPP2R2A/KDR/IKBKB/PKN2/PPP2R1B/GNG5/COL9A3/GNG11/AKT1/MAPK1/STK11/GSK3B/GNGT2/EIF4B/PPP2R5E/MAP2K2/CDC37/ITGA1/EFNA4/CSF1/YWHAH/PIK3R3/RELA/RHEB/GNG10/DDIT4/JAK2/IGF1R/IL3RA/CRTC2/PPP2R5B/MAP2K1/PHLPP1/MTOR/LAMC2/PIK3CG/KITLG/CREB3L4	1.40034648431866
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/2076	15/9376	1.80655105973025	NTPCR/ACP1/NFS1/AK2/AK1/TPK1	1.66707161075129
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	32/2076	116/9376	1.24589728257259	VAV3/GNAI3/PIK3CA/MYL12A/PRKCA/CDC42/PTK2/MYL12B/AFDN/CTNNB1/F11R/CLDN5/CTNND1/CD99/PECAM1/CDH5/RAP1A/BCAR1/CTNNA1/MSN/SIPA1/PTPN11/ARHGAP5/OCLN/PIK3R3/CLDN14/CLDN12/MAPK12/RAPGEF4/ESAM/GNAI2/RAP1B	1.42106882900384
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	32/2076	116/9376	1.24589728257259	GLS/GNAI3/GNB4/HOMER3/ADCY4/PRKCA/GNAS/PLCB1/PPP3R1/SLC38A2/PLA2G4C/PPP3CC/PPP3CA/GNG12/SHANK3/SLC38A1/PLCB4/GNG5/GNG11/GRIN2B/ITPR1/PRKACB/MAPK1/GNGT2/SLC17A7/PPP3CB/GRIK1/GNG10/ADCY6/PLA2G4A/GNAI2/ITPR3	1.42106882900384
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/2076	41/9376	1.43202218149349	RB1/MDM2/KRAS/MYC/BRAF/NRAS/HBEGF/RASSF1/CXCL8/MAPK1/DAPK1/MAP2K2/MAP2K1	1.47835486727539
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/2076	12/9376	1.88182402055234	CD46/NPC1/ASGR1/NCAM1/CLEC4M	1.62997043809558
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	30/2076	109/9376	1.24303971999788	HSP90AB1/HSP90AA1/NFKBIA/FOS/JUN/IFNGR1/TGFBR2/IFNGR2/STAT1/SMAD4/NFATC1/AHR/PPP3R1/NFKB1/PPP3CC/HIF1A/PPP3CA/MAPK8/NFKBIE/STAT3/IKBKB/MAPK1/MAPK9/PPP3CB/RELA/IL6ST/JAK2/MTOR/MAPK12/RARA	1.36100213463225
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	21/2076	73/9376	1.29923192651833	SOS2/GADD45A/HGF/POLK/PIK3CA/SOS1/PRKCA/RB1/KRAS/BRAF/STAT3/NRAS/RASSF1/AKT1/MAPK1/MAP2K2/PIK3R3/RARB/MAP2K1/GADD45B/DDB2	1.36866049188421
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	50/2076	193/9376	1.17004602314135	CXCL2/VAV3/NFKBIA/CXCL1/SOS2/GNAI3/GNB4/PIK3CA/SOS1/ADCY4/STAT1/CDC42/PTK2/PLCB1/CXCL3/NFKB1/STAT2/ELMO1/KRAS/PRKCZ/GNG12/BRAF/STAT3/ARRB1/RAP1A/NRAS/IKBKB/PLCB4/BCAR1/SHC1/GNG5/GNG11/CXCL8/AKT1/PRKACB/MAPK1/GSK3B/GNGT2/FGR/PIK3R3/RELA/GNG10/JAK2/MAP2K1/ADCY6/PIK3CG/GNAI2/SHC2/CCL21/RAP1B	1.27288956039825
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/2076	20/9376	1.58073217726397	LBR/HSD17B7/MSMO1/LIPA/SC5D/EBP/CYP51A1	1.3863844038172
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	14/2076	47/9376	1.34530398065019	PIK3CA/SOCS2/SOCS4/PRKCZ/MAPK8/IKBKB/SOCS1/MAFA/MAPK1/MAPK9/PIK3R3/HK1/MTOR/SOCS3	1.26552535303403
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	21/2076	75/9376	1.26458574181118	HSPA5/ATF2/HSP90B1/ADCY4/PRKCA/GNAS/PDIA4/PLCB1/SLC26A4/CREB5/ASGR1/CREB1/PLCB4/CANX/ITPR1/PRKACB/ATP1A1/GSR/ADCY6/CREB3L4/ITPR3	1.22678972290208
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	17/2076	59/9376	1.30132915319552	CMPK2/NT5C3A/NT5C2/DHODH/DCK/NT5E/CMPK1/CDADC1/DTYMK/NME7/DCTPP1/DUT/NT5C3B/RRM2B/CANT1/CTPS2/TYMS	1.23813212451102
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	52/2076	204/9376	1.15123351845555	DDX5/VAV3/SOS2/IGF1/ITGA2/CAMK2D/PPP1CB/CASP3/HGF/SDC4/GAB1/PIK3CA/SOS1/ARHGEF12/PRKCA/ITGAV/CDC42/PTK2/PPP1CC/FZD6/MDM2/CTNNB1/ANK2/HIF1A/KRAS/ELK1/MYC/BRAF/STAT3/NRAS/KDR/HBEGF/HPSE/MSN/PLCE1/AKT1/ITPR1/PTPN11/PRKACB/MAPK1/EIF4B/MAP2K2/PIK3R3/IGF1R/FZD9/PDCD4/MAP2K1/HOXD10/MTOR/MAPK12/FRS2/ITPR3	1.16457912078259
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2076	44/9376	1.33438430548257	PARP4/POLB/PARG/TDG/POLE3/POLE4/PARP2/PCNA/RFC4/RFC5/POLG/SMUG1/POLD4	1.18555782490842
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	26/2076	97/9376	1.21057545239656	FOS/CAMK2D/GNAI3/GNB4/ADCY4/PRKCA/RASD1/GNAS/PER1/PLCB1/GNG12/CREB1/PLCB4/GNG5/GNG11/GRIN2B/ITPR1/CALM1/PRKACB/MAPK1/GNGT2/GNG10/ADCY6/GNAI2/CALML4/ITPR3	1.11168284761903
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	29/2076	110/9376	1.19068138027676	CDKN1B/MKNK2/IGF1/CAMK2D/IFNGR1/CUL2/PIK3CA/IFNGR2/PRKCA/VHL/NFKB1/HIF1A/TEK/EIF4E/EP300/STAT3/PDHB/AKT1/MAPK1/MAP2K2/PIK3R3/RELA/HK1/ELOC/EGLN1/IGF1R/MAP2K1/MTOR/EGLN3	1.07274466742472
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	26/2076	98/9376	1.19822264165782	VAV3/ARPC5L/PIK3CA/CFL2/MARCKSL1/PRKCA/CDC42/DOCK1/ARPC1B/PLA2G4C/ARF6/LIMK2/ARPC1A/WASF3/ACTR3/ACTR2/AKT1/MAPK1/PIP5K1A/PIK3R3/MARCKS/ASAP2/MAP2K1/ACTR3C/WASF1/PLA2G4A	1.05190615438661
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	14/2076	49/9376	1.29039361409304	ATF2/JUN/GNAI3/GNAS/NFKB1/CREB5/FOSB/CREB1/GRIN2B/PRKACB/RELA/GNAI2/RGS9/CREB3L4	1.08680592177713
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	54/2076	217/9376	1.12389121227458	HSP90AB1/HSP90AA1/PTGES3/KLF4/GSTM3/FOS/SOS2/ATF2/MGST2/JUN/GNAI3/DLL4/HSP90B1/PIK3CA/SOS1/KPNA4/ADCY4/PRKCA/RPS6KA3/GNAS/EPHX4/AHR/RB1/NFKB1/CREB5/KPNA3/KRAS/EPHX1/MYC/CREB1/ADRB2/CCND3/STAT3/ARRB1/NRAS/PAQR8/AKT1/PRKACB/MAPK1/GSTA4/MAP2K2/PIK3R3/RELA/GSTO1/JAK2/MAP2K1/ADCY6/MTOR/EPHX2/JAG1/GNAI2/ESR2/MGST3/CREB3L4	0.984655299550701
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2076	18/9376	1.50545921644188	ACSL3/ACSL4/CBR4/ACACB/ACACA/MCAT	1.14463951550128
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/2076	154/9376	1.14375797612792	FOS/CAMK2D/PPP1CB/JUN/GNAI3/ADCY4/PRKCA/GNAS/NFATC1/PPP1CC/PLCB1/PPP3R1/PLA2G4C/PPP3CC/KRAS/PPP3CA/MAPK7/ELK1/MEF2C/PRKAA1/CAMKK2/PRKAA2/NRAS/PLCB4/ITPR1/CALM1/PRKACB/MAPK1/MAP2K5/MAP2K2/PPP3CB/MAP2K1/ADCY6/PLA2G4A/PIK3CG/GNAI2/CALML4/ITPR3/MYLK	0.959218694366267
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	38/2076	150/9376	1.14414900449583	CDKN1B/SOS2/GADD45A/HGF/POLK/GAB1/TGFBR2/PIK3CA/SOS1/SMAD4/CDK2/RB1/FZD6/CTNNB1/KRAS/FRAT2/TGFB3/MYC/BRAF/NRAS/CSNK1A1/APC/SHC1/CTNNA1/AKT1/LRP6/MAPK1/GSK3B/MAP2K2/PIK3R3/RARB/MLH1/FZD9/MAP2K1/GADD45B/DDB2/MTOR/SHC2	0.949048560057927
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2076	54/9376	1.2545493470349	BHMT2/AMD1/CISD1/MPST/APIP/GOT2/ADI1/MDH1/MAT2B/LACC1/MAT2A/MRI1/GCLM/DNMT3A/ENOPH1	1.00035051641495
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/2076	46/9376	1.27636759654855	PSMA2/PSMD12/PSMC6/PSMB9/PSMB2/PSMD11/PSMA3/PSME4/PSMA5/PSMC2/PSMA1/PSMB8/PSMB5	1.00198933355503
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/2076	104/9376	1.172521120498	ETNK1/PLA2G4C/CHKA/AGPAT5/CHPT1/CEPT1/CDS2/LYPLA1/PGS1/LPIN2/SAMD8/GPAT3/LPGAT1/DGKE/GNPAT/SGMS1/AGPAT4/ACHE/DGKZ/SELENOI/PLA2G15/LYPLA2/GPD1L/CDIPT/MBOAT1/PLA2G4A/LPCAT3	0.943430931622099
Organismal Systems	Immune system	hsa04611	Platelet activation	32/2076	126/9376	1.14701654586048	ITGA2/PPP1CB/GNAI3/PIK3CA/MYL12A/ARHGEF12/SNAP23/ADCY4/GNAS/PPP1CC/MYL12B/PLCB1/PLA2G4C/PRKCZ/RAP1A/PLCB4/GNA13/AKT1/ITPR1/PRKACB/MAPK1/FYN/PIK3R3/PRKCI/ADCY6/MAPK12/PLA2G4A/PIK3CG/GNAI2/RAP1B/ITPR3/MYLK	0.88596895415597
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/2076	59/9376	1.22478037947814	GSTM3/MGST2/GGT5/LAP3/TXNDC12/IDH1/GGCT/LANCL1/GSTA4/GCLM/RRM2B/GSR/GSTO1/GSTK1/ODC1/MGST3	0.923600673350968
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	58/2076	238/9376	1.10062984731465	MX1/OAS1/OAS2/NFKBIA/MX2/TBK1/FOS/RPL26/TRAF6/EIF2AK2/JUN/ISG15/ADAM17/RPL37/PIK3CA/RPS21/RPL36A/OAS3/STAT1/PRKCA/RPS10/IFIH1/RPL22L1/CASP1/NFKB1/STAT2/ADAR/TNFRSF1A/CGAS/RSL24D1/MAPK8/IFNAR1/IRAK4/STAT3/IKBKB/HBEGF/CXCL8/RPS15A/RPS23/RPS7/MAPK1/MAP3K7/RPS13/RPL30/TLR3/MAPK9/MYD88/PIK3R3/RELA/IL6ST/RPL39/IL12A/RPL26L1/C1R/MAPK12/CFB/RPL14/RPL32	0.838547364139595
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	26/2076	101/9376	1.16263187012343	CAMK2D/GNAI3/EDNRB/ADCY4/PRKCA/GNAS/FZD6/PLCB1/CTNNB1/KRAS/CREB1/EP300/NRAS/PLCB4/CALM1/PRKACB/MAPK1/GSK3B/MAP2K2/FZD9/MAP2K1/ADCY6/GNAI2/KITLG/CALML4/CREB3L4	0.876288811246653
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/2076	51/9376	1.23978994295213	PRKCA/GNAS/PDIA4/ATP6V1C1/ERO1A/ATP6V0A1/ARF1/PRKACB/ATP6V1G1/TJP2/KDELR1/ATP6V1E2/TJP1/SLC12A2	0.915650031966756
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	23/2076	89/9376	1.16715377454482	SOS2/GNAI3/SOS1/ADCY4/PRKCA/GNAS/PLCB1/KRAS/MAPK7/NRAS/PLCB4/ITPR1/CSNK1D/PRKACB/MAPK1/TUBB2A/MAP2K5/MAP2K2/MAP2K1/ADCY6/TJP1/GNAI2/ITPR3	0.844911752814914
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2076	27/9376	1.33818597017056	HSD17B4/SCP2/ELOVL5/ELOVL1/HACD2/HSD17B12/HACD3/ACOT2	0.938410312219376
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/2076	149/9376	1.12151659748354	GABRE/GNAI3/GNB4/NDUFB5/ADCY4/PRKCA/NDUFC2/PLCB1/NDUFB3/NDUFV2/GNG12/MT-ND6/MAPK8/NDUFA5/PLCB4/NDUFA8/GNG5/GNG11/NDUFS4/ITPR1/NDUFA7/NDUFC1/NDUFB8/PRKACB/MAPK1/NDUFB4/GNGT2/MAPK9/NDUFB6/NDUFA6/SLC17A7/GNG10/NDUFA9/ADCY6/MAPK12/GNAI2/ITPR3	0.797326791263173
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/2076	73/9376	1.1754955525642	IGF1/GADD45A/HGF/POLK/PIK3CA/PTEN/RB1/MDM2/KRAS/BRAF/NRAS/AKT1/MAPK1/MAP2K2/PIK3R3/IGF1R/MAP2K1/GADD45B/DDB2	0.802701209362097
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	38/2076	154/9376	1.11443084853489	ATF2/PPP2R5A/CAMK2D/PPP1CB/GNAI3/ADCY4/PRKCA/GNAS/PPP1CC/PLCB1/PPP2R3C/PPP2R2D/ATP2A2/SCN1B/CREB5/PPP2R5C/PPP2CB/PPP2CA/CREB1/ADRB2/PPP2R2A/PLCB4/PPP2R1B/AKT1/CALM1/PRKACB/MAPK1/ATP1A1/PPP2R5E/TPM4/PPP2R5B/ADCY6/MAPK12/RAPGEF4/PIK3CG/GNAI2/CALML4/CREB3L4	0.763534741398945
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/2076	69/9376	1.17818547373712	GNAI3/PDE1A/GNAS/PLCB1/PPP3R1/PPP3CC/PPP3CA/CREB1/ADRB2/PLCB4/ITPR1/CALM1/PRKACB/PPP3CB/ADCY6/GNAI2/CALML4/ITPR3	0.792190932609317
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	26/2076	103/9376	1.14005649400453	CXCL2/CXCL1/CASP3/PIK3CA/PRKCA/GNAS/ARG2/PTK2/RAB5A/PLCB1/CXCL3/NFKB1/COL4A1/TGFB3/LAMB1/SERPINB9/PLCB4/CXCL8/RAB5B/RAB7A/PRKACB/PIK3R3/RELA/PRDX1/IL12A/LAMC2	0.762166078347362
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/2076	65/9376	1.18120646213132	PIK3CA/PRKCA/PLCB1/KCNN3/KRAS/ARRB1/NRAS/PLCB4/AKT1/ITPR1/MAPK1/MAP2K2/KCNN2/PIK3R3/MAP2K1/ESR2/ITPR3	0.781753940505934
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	34/2076	138/9376	1.11273072519617	SDHD/NDUFB5/CYCS/NDUFC2/NDUFB3/ATP6V1C1/NDUFV2/MT-ND6/COX11/NDUFA5/UQCRC2/ATP5F1C/ATP6V0A1/NDUFA8/NDUFS4/NDUFA7/UQCRFS1/NDUFC1/NDUFB8/NDUFB4/COX10/COX7A2L/UQCRH/NDUFB6/SDHB/NDUFA6/ATP6V1G1/NDUFA9/SDHC/COX17/ATP6V1E2/COX15/COX7B/ATP5MG	0.71142766235564
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/2076	28/9376	1.29039361409304	GCH1/SPR/MOCS2/PCBD1/PTS/AKR1C3/DHFR/CBR1	0.820624744675884
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/2076	20/9376	1.35491329479769	CMAS/CYB5RL/GMDS/NANP/UGP2/TGDS	0.8472860225054
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/2076	49/9376	1.19822264165782	C1GALT1C1/OGT/GXYLT1/GALNT7/GALNT18/ST6GAL1/B4GALT1/POGLUT1/B3GLCT/FUT10/XXYLT1/MFNG/GALNT1	0.741853575041098
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	40/2076	166/9376	1.08828377092184	ATF2/PPP1CB/GNAI3/EDNRB/ADCY4/NFATC1/PPP1CC/PLCB1/PPP3R1/VDAC3/ATP2A2/PPP3CC/CREB5/GTF2I/PPP3CA/MEF2C/CREB1/ADRB2/VDAC2/PLCB4/GNA13/TRPC6/VDAC1/AKT1/ITPR1/CALM1/SLC25A5/MAPK1/ATP1A1/MAP2K2/PPP3CB/MAP2K1/ADCY6/MEF2D/PIK3CG/GNAI2/CALML4/CREB3L4/ITPR3/MYLK	0.611988113229117
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/2076	33/9376	1.23173935890699	IDH1/ACO1/DLST/GOT2/PDHB/IDH3A/DBT/DLD/NAGS	0.711134059358366
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/2076	50/9376	1.17425818882466	ALDH2/AMD1/CNDP2/LAP3/ARG2/SAT2/ALDH9A1/ALDH3A2/P4HA1/GOT2/AZIN2/ODC1/L3HYPDH	0.658822427874859
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/2076	21/9376	1.29039361409304	CSGALNACT1/CHST15/DSEL/CHST12/CSGALNACT2/CHST7	0.71041593764382
NA	NA	hsa04517	IgSF CAM signaling	70/2076	299/9376	1.05734593796921	VAV3/MPDZ/NCK1/PARD6G/DYNLL1/TRAF6/MYH10/SRGAP2/ARPC5L/PIK3CA/MYL12A/PRKCA/CDC42/NECTIN3/PTK2/WASL/MYL12B/ARPC1B/AFDN/NRP2/MTSS1/ARF6/CTNNB1/F11R/ANK2/ARPC1A/APP/CASK/CD2AP/MAPK8/SPTAN1/NCAM1/ACTR3/RAP1A/CLEC4M/KDR/NCK2/BCAR1/EPB41L2/TRPC6/MSN/ACTR2/AKT1/BAIAP2/NTN1/PTPN11/MAPK1/TUBB2A/GSK3B/RAPGEF2/MAPK9/MAP2K2/ERC1/FYN/PMP22/TJP2/PIK3R3/TRIO/PRKCI/SSX2IP/MAP2K1/ACTR3C/MAPK12/ESAM/TJP1/CADM4/RAP1B/SPTBN1/MAP2/MYLK	0.537409042651698
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/2076	42/9376	1.18286081291862	ALDH2/ALDH9A1/ALDH3A2/DLST/HADH/AFMID/ACAT2/DLD/ECHS1/CAT/IDO1	0.63335802222451
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/2076	42/9376	1.18286081291862	ACSL3/MAP1LC3B/ATG5/VDAC3/SLC39A14/SAT2/VDAC2/ACSL4/GCLM/CP/LPCAT3	0.63335802222451
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2076	17/9376	1.32834636744871	SEPHS2/TXNRD1/SEPHS1/SEPSECS/PAPSS1	0.722569849247497
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/2076	17/9376	1.32834636744871	MYH10/NRP2/PCDH9/LAMP2/CLEC4M	0.722569849247497
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2076	13/9376	1.38965466133096	MRE11/RAD50/DCLRE1C/LIG4	0.749690354295044
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/2076	30/9376	1.2043673731535	PIGK/PIGA/PIGF/PIGH/PIGG/PIGP/PIGN/PIGC	0.597856815457752
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/2076	30/9376	1.2043673731535	ABCC5/NFKB1/IKBKB/GART/RELA/ABCC1/DHFR/TYMS	0.597856815457752
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/2076	99/9376	1.09487943013955	IGF1/CAMK2D/PPP1CB/PIK3CA/ADCY4/PRKCA/GNAS/PPP1CC/PLCB1/PLA2G4C/MAPK8/MAP2K3/MAP2K6/PLCB4/ITPR1/CALM1/PRKACB/MAPK9/PIK3R3/ADCY6/MAPK12/PLA2G4A/CALML4/ITPR3	0.506085354248892
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/2076	82/9376	1.10155552422576	HSPA1A/HSPA1B/HSP90AB1/HSP90AA1/HSPA5/HSPA8/CALR/HSPA4/NFYB/HSPA6/B2M/TAP1/PDIA3/NFYA/TAP2/CREB1/CANX/HLA-F/NFYC/RFX5	0.492546261619166
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/2076	78/9376	1.10014327355368	NFKBIA/FOS/TRAF6/JUN/IFNGR1/MARCKSL1/IFNGR2/STAT1/NFKB1/ELK1/TGFB3/IRAK4/MAPK1/MAP3K7/MYD88/RELA/JAK2/IL12A/MAPK12	0.473600548799611
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/2076	52/9376	1.12909441233141	CD36/MYLIP/STARD3NL/STARD3/VDAC3/NPC1/VAPB/VAPA/VDAC2/LIPA/VDAC1/LDLRAP1/LIPC	0.497789655067118
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/2076	31/9376	1.16551681272919	ALDH2/CNDP2/HIBCH/ALDH9A1/ALDH3A2/CSAD/ALDH6A1/ECHS1	0.492233527581006
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/2076	31/9376	1.16551681272919	HSPA5/SRP9/SRP54/SPCS3/SRPRA/SPCS2/SEC11A/IMMP2L	0.492233527581006
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	30/2076	128/9376	1.05852601156069	NTPCR/NUDT9/PDE1A/ADCY4/PNP/GMPR2/NT5C2/PDE6D/DCK/NT5E/PDE4B/AK6/GMPS/PGM2/NME7/LACC1/GART/HPRT1/PRPS1/ENPP4/RRM2B/CANT1/DGUOK/PPAT/PAPSS1/ADCY6/AK2/AK1/ADSL/PRUNE1	0.355523150462751
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/2076	71/9376	1.08138619772585	GLS/PIK3CA/IDH1/PTEN/HIF1A/KRAS/MYC/NRAS/PDHB/AKT1/MAPK1/SIRT6/MAP2K2/PIK3R3/HK1/MAP2K1/MTOR	0.367079074060062
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	36/2076	155/9376	1.04896513145627	CDKN1B/ATF2/CAMK2D/GNAI3/ADCY4/RASD1/GNAS/CDKN2C/CDK2/AHR/RB1/FZD6/PLCB1/CTNNB1/CREB5/SP1/BRAF/CREB1/RAP1A/APC/PLCB4/ITPR1/PRKACB/MAPK1/FH/GSK3B/MAP2K2/ASH2L/FZD9/MAP2K1/ADCY6/ARMC5/GNAI2/RAP1B/CREB3L4/ITPR3	0.327794487349242
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/2076	19/9376	1.18852043403306	DLST/PDHB/DBT/LIPT1/DLD	0.438636532220033
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	53/2076	232/9376	1.03175868713042	VAV3/SOS2/ARHGEF7/ITGA2/PPP1CB/MYH10/ARPC5L/PIK3CA/MYL12A/SOS1/CFL2/ARHGEF12/ITGAV/CDC42/DOCK1/PTK2/PPP1CC/WASL/MYL12B/ARPC1B/NCKAP1/ITGA9/CYFIP1/LIMK2/ARPC1A/PIP4K2A/SSH2/KRAS/GNG12/BRAF/ACTR3/NRAS/ABI2/APC/BCAR1/GNA13/MSN/ACTR2/AKT1/BAIAP2/ARHGEF6/MAPK1/MAP2K2/BRK1/ITGA1/PIKFYVE/PIP5K1A/PIK3R3/SSH1/MAP2K1/ACTR3C/WASF1/MYLK	0.261201885350687
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2076	15/9376	1.2043673731535	ST8SIA1/ST6GALNAC3/ST3GAL2/ST6GALNAC4	0.422409767909747
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/2076	37/9376	1.09857834713326	CMAS/GALK2/PGM2/GMDS/GNPNAT1/NANP/UGP2/HK1/TGDS	0.320383461362318
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2076	16/9376	1.12909441233141	ST8SIA1/A4GALT/ST3GAL2/GLA	0.275592500046496
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	30/2076	133/9376	1.01873180059977	VAV3/SOS2/CASP3/IFNGR1/PIK3CA/SOS1/IFNGR2/PRKCA/NFATC1/BID/PPP3R1/PPP3CC/TNFRSF10B/KRAS/SH3BP2/PPP3CA/MICB/BRAF/IFNAR1/NRAS/TNFSF10/SHC1/PTPN11/MAPK1/MAP2K2/PPP3CB/FYN/PIK3R3/MAP2K1/SHC2	0.116021039636776
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	26/2076	115/9376	1.02109407723884	DUSP1/CASP3/GNAI3/GNB4/PRKCA/GNAS/PLCB1/PLA2G4C/APP/KRAS/GNG12/BRAF/NRAS/PLCB4/GNG5/GNG11/ITPR1/PRKACB/MAPK1/GNGT2/KCNN2/GNG10/MAP2K1/PLA2G4A/GNAI2/ITPR3	0.12137196766269
NA	NA	hsa03272	Virion - Hepatitis viruses	11/2076	48/9376	1.03500321130379	CHMP7/LAMP2/IST1/CLDN5/CHMP4B/TSG101/PDCD6IP/CHMP1B/OCLN/CLDN14/CLDN12	0.129649880979465
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2076	39/9376	1.04224099599822	BHMT2/MTHFS/MTHFD2L/MAT2B/GART/DLD/MAT2A/DHFR/TYMS	0.140961546798132
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/2076	21/9376	1.0753280117442	ALDH2/ALDH3A2/CSAD/PANK3/AASDHPPT	0.184281669764795
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2076	12/9376	1.12909441233141	NQO1/COQ2/COQ5	0.238619124586461
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/2076	17/9376	1.06267709395897	HSD17B4/SCP2/CYP39A1/ACOT8	0.13792928085394
NA	NA	hsa04981	Folate transport and metabolism	7/2076	31/9376	1.01982721113804	BHMT2/MTHFS/ABCC5/ABCC1/DHFR/FOLH1/TYMS	0.0589645119407966
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2076	22/9376	1.02644946575582	ALDH2/CNDP2/ALDH9A1/ALDH3A2/CARNMT1	0.0662319351937745
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/2076	37/9376	0.976514086340676	GLS/ASRGL1/GLUD1/RIMKLB/GOT2/PPAT/FOLH1/ADSL	-0.0763301326330722
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/2076	23/9376	0.981821228114267	GLS/ARG2/GLUD1/GOT2/NAGS	-0.0465469119030847
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2076	28/9376	0.967795210569777	GCNT2/B3GNT5/ST3GAL6/ST8SIA1/A4GALT/B4GALT1	-0.0910076731062355
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/2076	168/9376	0.967795210569777	IL7/SOS2/LIF/STAM2/IFNGR1/MCL1/PIK3CA/SOS1/IFNGR2/STAT1/SOCS2/FHL1/SOCS4/STAT2/MYC/IFNAR1/CCND3/EP300/STAT3/IL15RA/SOCS1/PIAS1/SOCS6/PIAS2/AKT1/PTPN11/STAM/PIK3R3/IL6ST/JAK2/IL3RA/IL12A/TSLP/MTOR/SOCS3/IL13RA1	-0.224610643540626
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/2076	52/9376	0.955387579665036	IGF1/ADCY4/GNAS/PLA2G4C/HSD17B7/PRKACB/AKR1C3/IGF1R/ADCY6/ACOT2/PLA2G4A	-0.172026046125376
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/2076	38/9376	0.950816347226448	IGF1/PIK3CA/PRKCA/KRAS/NR3C2/MAPK1/ATP1A1/PIK3R3	-0.162003174979464
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/2076	76/9376	0.950816347226448	CAMK2D/GNAI3/ADCY4/PRKCA/GNAS/PLCB1/PLCB4/ITPR1/CALM1/PRKACB/ATP1A1/ADCY6/GNAI2/CALML4/ITPR3/MYLK	-0.229574678286253
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/2076	86/9376	0.945288345207689	ATF2/CAMK2D/PCLO/ADCY4/PRKCA/GNAS/PLCB1/KCNN3/CREB5/CREB1/PLCB4/PRKACB/ATP1A1/KCNN2/ADCY6/RAPGEF4/CREB3L4/ITPR3	-0.271806039118751
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/2076	53/9376	0.937361398916639	PRKCA/GNAS/PLCB1/CLTC/RAB11A/PLCB4/PRKACB/ATP1A1/CLTA/ADCY6/AP2M1	-0.243859694512284
Genetic Information Processing	Translation	hsa03010	Ribosome	47/2076	222/9376	0.956170042875245	MRPL18/RPL26/RPL37/MRPL44/RPS21/RPL36A/MRPL42/RPS10/RPL22L1/MRPL50/MRPL32/MRPL9/MRPS18C/MRPS22/MRPL19/RSL24D1/MRPL15/MRPL43/MRPL13/MRPS30/MRPS35/MRPL35/MRPL30/MRPL47/MRPL11/MRPL49/MRPS10/MRPS28/RPS15A/RPS23/MRPL45/RPS7/MRPL52/MRPL34/RPS13/RPL30/MRPS5/MRPS27/MRPL10/MRPS14/MRPS31/RPL39/RPL26L1/MRPS7/RPL14/MRPL53/RPL32	-0.352435755075428
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/2076	45/9376	0.903275529865125	ABCG1/ABCD4/TAP1/ABCC5/TAP2/ABCD3/ABCA6/ABCC1/ABCC10	-0.346829798984568
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	32/2076	155/9376	0.932413450183355	CALR/CD36/ITGA2/SEC22B/STX12/MRC1/ITGAV/RAB5A/ATP6V1C1/DYNC1I1/TAP1/STX7/M6PR/LAMP2/COLEC12/VAMP3/TAP2/RILP/PIK3C3/CLEC4M/ATP6V0A1/CANX/RAB5B/HLA-F/RAB7A/TUBB2A/DYNC1LI2/ATP6V1G1/PIKFYVE/DYNC1H1/ATP6V1E2/C1R	-0.452454589418083
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/2076	65/9376	0.903275529865125	ALDH2/AGPAT5/ALDH9A1/ALDH3A2/LPIN2/GPAT3/DGKE/AGPAT4/DGKZ/GLA/MBOAT1/LIPC/GLYCTK	-0.417284984111052
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/2076	65/9376	0.903275529865125	ATF2/ADCY4/GNAS/PLCB1/CREB5/SP1/CREB1/PLCB4/ITPR1/PRKACB/ADCY6/CREB3L4/ITPR3	-0.417284984111052
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	18/2076	89/9376	0.913424693122037	GLS/GABRE/GNAI3/GNB4/ADCY4/PRKCA/GABARAPL2/SLC38A2/GNG12/NSF/SLC38A1/GNG5/GNG11/PRKACB/GNGT2/GNG10/ADCY6/GNAI2	-0.437611980249558
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/2076	31/9376	0.874137609546895	DERA/RPE/PGM2/PRPS1/RPIA/GLYCTK	-0.374304503699413
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2076	26/9376	0.868534163331851	LMBRD1/ABCD4/CUBN/ABCC1/FOLH1	-0.357957660457317
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/2076	36/9376	0.878184542924427	C1GALT1C1/ST6GALNAC3/GALNT7/GALNT18/ST3GAL2/GALNT1/ST6GALNAC4	-0.390497352784943
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/2076	27/9376	0.836366231356597	HMGCS1/HADH/ACAT2/ECHS1/ACSM2A	-0.454056730516782
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2076	17/9376	0.797007820469228	GGT5/CSAD/FMO5	-0.446711287539616
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/2076	28/9376	0.806496008808148	ATP6V1C1/ATP6V0A1/ATP6V1G1/ATP6V1E2/SLC12A7	-0.546823881997295
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/2076	98/9376	0.87562423813456	ATF2/PRKD3/CAMK2D/ADCY4/PRKCA/GNAS/PLCB1/CREB5/ATF1/CREB1/PLCB4/ITPR1/CALM1/PRKACB/ATP1A1/ADCY6/CALML4/CREB3L4/ITPR3	-0.660023639421709
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/2076	23/9376	0.785456982491413	GLS/GLUD1/MDH1/ATP1A1	-0.549339361215668
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/2076	59/9376	0.842036510891218	GNAI3/PIK3CA/ADCY4/GNAS/ADRB2/ABHD5/AKT1/PRKACB/PIK3R3/ADCY6/GNAI2	-0.649056582449315
NA	NA	hsa04519	Cadherin signaling	83/2076	404/9376	0.927869665579275	SAV1/VAV3/NFKBIA/MPDZ/PPP1CB/GABRE/ARPC5L/RYK/PCDHGB7/PCDHGA10/STK3/MYO7A/TEAD2/CDC42/SHOC2/DSP/PTK2/PPP1CC/FZD6/ARPC1B/AFDN/FLT4/MOB1A/NCKAP1/CTNNB1/ERBIN/NFKB1/CYFIP1/PCDH9/PCDHGA12/SCN1B/ARPC1A/PCDHGB5/YAP1/KRAS/MYO1D/MYO1B/CTNND1/FAT4/WWTR1/MAPK8/YWHAG/MAP2K3/CDH26/PCDH12/YWHAQ/EP300/ACTR3/CDH5/PSEN1/TEAD4/ADAM10/NRAS/KDR/IKBKB/CSNK1A1/ABI2/APC/LATS1/PCDHGC3/CTNNA1/ACTR2/CDH22/LRP6/MAPK1/GSK3B/MAPK9/PCDHGB6/MAP2K2/BRK1/YWHAH/RELA/IGF1R/MOB1B/PCDHGA8/FZD9/MAP2K1/ACTR3C/PCDHGA9/WASF1/MAPK12/TJP1/TMC7	-0.790318009411023
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/2076	134/9376	0.876312081212435	CALCRL/PPP1CB/MYH10/ARHGEF12/ADCY4/PRKCA/GNAS/PPP1CC/PLCB1/PLA2G4C/ARHGEF11/BRAF/RAMP2/PLCB4/GNA13/ITPR1/CALM1/PRKACB/MAPK1/MAP2K2/MAP2K1/ADCY6/PLA2G4A/CALML4/ITPR3/MYLK	-0.769014594187938
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/2076	91/9376	0.84371890152237	GABRE/GNAI3/GNB4/PDE1A/ADCY4/PRKCA/GNAS/PDE4B/GNG12/ARRB1/GNG5/GNG11/PRKACB/GNGT2/GNG10/ADCY6/GNAI2	-0.798866261520038
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/2076	66/9376	0.821159572604659	JUN/IFNGR1/IFNGR2/STAT1/NFATC1/NFKB1/TLR5/TGFB3/MAF/STAT3/RELA/IL12A	-0.777500557468294
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2076	46/9376	0.785456982491413	CPOX/ALAS1/HCCS/HEPH/COX10/ALAD/COX15/CP	-0.777840158603948
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/2076	36/9376	0.752729608220938	PGM2/PGM2L1/GYG1/UGP2/HK1/GBE1	-0.79266158605731
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/2076	14/9376	0.645196807046518	B4GALT1/ST3GAL2	-0.708443306993784
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/2076	37/9376	0.732385564755507	PRKCA/PLCB1/PLCB4/MYD88/IL12A/IDO1	-0.869757320623852
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	4/2076	26/9376	0.694827330665481	HES1/HHEX/NR5A2/MAFA	-0.830929901783108
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/2076	32/9376	0.705684007707129	PGM2/B4GALT1/UGP2/HK1/GLA	-0.889324625344448
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/2076	38/9376	0.713112260419836	GNPDA2/GALK2/PGM2/GNPNAT1/UGP2/HK1	-0.944962849519386
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/2076	70/9376	0.774236168455822	CASP3/EIF4G2/SGCE/CYCS/BID/SGCB/SGCD/HLA-F/FYN/SNTB2/CASP8/CD55	-1.01101999728719
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/2076	76/9376	0.772538282121489	CD36/HMGCS1/ACSL3/SCP2/FABP5/ACADM/PPARG/PLIN5/CPT1A/DBI/ACSL4/UBC/PPARD	-1.0617237183424
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/2076	55/9376	0.739043615344193	CERS2/DEGS1/GALC/SPTLC2/SPTLC1/SAMD8/NEU1/SGMS1/GLA	-1.0350370605361
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	43/2076	226/9376	0.859310791685849	VAV3/NFKBIA/FOS/CAMK2D/PPP1CB/JUN/GNAI3/PIK3CA/ADCY4/GNAS/NFATC1/PPP1CC/AFDN/ATP2A2/NFKB1/PDE4B/CREB5/MAPK8/BRAF/ARAP3/CREB1/ADRB2/EP300/RAP1A/GRIN2B/PLCE1/AKT1/CALM1/PRKACB/MAPK1/MAPK9/ATP1A1/MAP2K2/PIK3R3/RELA/MAP2K1/ADCY6/RAPGEF4/GNAI2/VIP/CALML4/RAP1B/CREB3L4	-1.14167460547363
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/2076	82/9376	0.771088866958034	GSTM3/MGST2/CMPK1/GMPS/CDADC1/NME7/TPMT/DUT/HPRT1/GSTA4/RRM2B/GSTO1/NAT1/MGST3	-1.11022343375611
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2076	29/9376	0.622948641286293	SLC24A1/CALM1/CALML4/RGS9	-1.08442936806508
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/2076	63/9376	0.716885341162798	GADD45A/POLK/BMP2/FZD6/CTNNB1/APC/GSK3B/FZD9/GADD45B/DDB2	-1.2023356167894
Human Diseases	Substance dependence	hsa05034	Alcoholism	35/2076	191/9376	0.827608469771712	SOS2/ATF2/PPP1CB/GNAI3/GNB4/SOS1/HAT1/GNAS/PPP1CC/CREB5/KRAS/GNG12/BRAF/FOSB/CAMKK2/CREB1/NRAS/SHC1/GNG5/HDAC1/GNG11/HDAC8/GRIN2B/CALM1/PRKACB/MAPK1/GNGT2/PKIA/GNG10/HDAC5/MAP2K1/GNAI2/SHC2/CALML4/CREB3L4	-1.28360355348912
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/2076	17/9376	0.531338546979485	GLUD1/CA5B	-1.03135185593317
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/2076	75/9376	0.7226204238921	IDH1/ARG2/ACO1/RPE/GOT2/IDH3A/MAT2B/PSPH/MAT2A/PRPS1/RPIA/NAGS	-1.28611016974209
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/2076	48/9376	0.658638407193321	PIK3CA/PLCB1/PLCB4/AKT1/ATP1A1/PIK3R3/HK1	-1.26438370166212
NA	NA	hsa04518	Integrin signaling	27/2076	154/9376	0.791832445011636	IGF1/ITGA2/HGF/PIK3CA/PGF/ITGAV/CDC42/PTK2/FLT4/CTNNB1/ITGA9/COL4A1/RELN/LAMB1/CCND3/KDR/NCK2/COL9A3/AKT1/ARHGEF6/GSK3B/ITGA1/PARVB/PIK3R3/IGF1R/MTOR/LAMC2	-1.3889887412416
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/2076	93/9376	0.728448007955746	ADCY4/PRKCA/GNAS/PLCB1/ADRB2/PLCB4/ITPR1/CALM1/PRKACB/ATP1A1/PRH1/ADCY6/SLC12A2/CALML4/ITPR3	-1.40342165930943
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/2076	19/9376	0.475408173613224	HYAL2/HPSE	-1.22058460525779
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/2076	38/9376	0.59426021701653	TAP1/TAP2/DCLRE1C/RAG1/RFX5	-1.33644268678935
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/2076	50/9376	0.632292870905588	CD36/HGF/TGFB3/PECAM1/CXCL8/MYD88/IL12A	-1.39019982458689
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/2076	67/9376	0.674086216317258	ALDH2/ALDH9A1/ALDH3A2/PGM2/PDHB/MINPP1/DLD/HK1/ACSS2/ADPGK	-1.42766560639922
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/2076	105/9376	0.731223047986054	IGF1/ITGA2/ADCY4/SGCE/GNAS/ITGAV/ITGA9/ATP2A2/TGFB3/SGCB/SGCD/PRKACB/ITGA1/TTN/TPM4/SNTB2/ADCY6	-1.4769346053746
NA	NA	hsa04081	Hormone signaling	39/2076	219/9376	0.804286430701824	IGF1/SMAD9/GNAI3/SMAD1/GNB4/PIK3CA/ADCY4/SMAD4/GNAS/ITGAV/SMAD5/PLCB1/ADIPOR2/GNG12/ADIPOR1/ADRB2/STAT3/RAMP2/PLCB4/GNA13/GNG5/THRA/GNG11/HEPH/PRKACB/STK11/GNGT2/PIK3R3/GNG10/JAK2/AVPR2/IGF1R/ADCY6/SLC16A2/RAPGEF4/GNAI2/VIP/ESR2/ACVR1	-1.56280312311407
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/2076	51/9376	0.619894971476066	AGPS/PLA2G4C/PAFAH1B1/CHPT1/CEPT1/SELENOI/PLA2G4A	-1.45145028700449
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/2076	63/9376	0.645196807046518	PTGES3/GGT5/PLA2G4C/LTA4H/PTGR1/AKR1C3/EPHX2/PLA2G4A/CBR1	-1.506783568151
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/2076	70/9376	0.645196807046518	GSTM3/MGST2/EPHX1/SULT1A3/GSTA4/GSTO1/GSTK1/NAT1/CBR1/MGST3	-1.58888658437355
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/2076	35/9376	0.516157445637214	ENOSF1/GMDS/HK1/KHK	-1.52925278869856
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/2076	99/9376	0.684299643837216	IGF1/ITGA2/SGCE/ITGAV/ITGA9/ATP2A2/TGFB3/SGCB/PRKAA1/PRKAA2/SGCD/ITGA1/TTN/TPM4/SNTB2	-1.68394062179924
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/2076	89/9376	0.659695611699249	SV2B/CD36/ITGA2/SDC4/CD47/ITGAV/ITGA9/COL4A1/RELN/LAMB1/COL9A3/ITGA1/LAMC2	-1.72013571331403
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2076	37/9376	0.488257043170338	FAHD1/GOT2/LRTOMT/COMT	-1.66318450861463
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/2076	102/9376	0.664173183724357	RAB8A/ADCY4/PRKCA/GNAS/PLCB1/ATP2A2/RAP1A/RAB11A/PLCB4/ITPR1/ATP1A1/ADCY6/SLC12A2/RAP1B/ITPR3	-1.81852717417026
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/2076	31/9376	0.437068804773448	ALDH2/ALDH9A1/ALDH3A2	-1.67411155062004
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/2076	86/9376	0.630192230138459	ITGA2/SGCE/ITGAV/DSP/CTNNB1/ITGA9/ATP2A2/SGCB/CTNNA1/SGCD/ITGA1/SNTB2	-1.83719511944885
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/2076	24/9376	0.376364804110469	HS6ST1/HS2ST1	-1.63125506008081
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2076	16/9376	0.282273603082852	GOT2	-1.53221203384059
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/2076	95/9376	0.618030625697191	CXCL2/CXCL1/FOS/JUN/ATP6V1C1/CXCL3/TGFB3/TEK/ATP6V0A1/CXCL8/ATP6V1G1/CSF1/ATP6V1E2	-1.99540401759743
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	29/2076	183/9376	0.715710119292039	XPO1/RIOK2/NMD3/XRN1/HEATR1/BMS1/CSNK2A2/NOP10/AK6/NXT1/RPP30/GNL3L/RPP38/NVL/NXF1/UTP18/WDR75/CSNK2A1/RAN/NOB1/POP7/XRN2/WDR36/PWP2/LSG1/NOP58/SBDS/REXO2/RPP25	-2.07107677629183
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	56/2076	323/9376	0.783025227127663	GLS/EFNA5/CDKN1B/CDC25B/SOS2/CASP3/MCL1/STMN1/PIK3CA/SOS1/SIRT1/BCL2L11/PRKCA/PTEN/EFNA1/CCNG1/MDM2/NOTCH1/NFKB1/MMP16/KRAS/MAPK7/RECK/MYC/ATM/ZFPM2/EP300/STAT3/NRAS/SLC45A3/IKBKB/SOCS1/APC/RASSF1/SHC1/HDAC1/MDM4/MAPK1/UBE2I/HNRNPK/SPRY2/BCL2L2/MAP2K2/DNMT3A/EFNA4/EZH2/PIK3R3/BMI1/DDIT4/ABCC1/HDAC5/MARCKS/PDCD4/MAP2K1/HOXD10/MTOR	-2.11617766391342
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2076	26/9376	0.34741366533274	PLA2G4C/PLA2G4A	-1.77687438443469
Cellular Processes	Cell motility	hsa04814	Motor proteins	31/2076	194/9376	0.721689212005641	DYNLL1/MYH10/MYL12A/CAPZA2/MYO7A/KIF2A/MYL12B/MYO5C/DYNC1I1/DYNLT3/KIF3C/MYO18A/MYO1D/MYO1B/ACTR10/TUBE1/DCTN6/MYO6/KIF9/DYNLT1/KIF1B/KIF13B/TUBB2A/MYO9A/DYNC1LI2/KIF6/TUBD1/TPM4/STARD9/DYNC1H1/KIF27	-2.08881580270952
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/2076	41/9376	0.440622209690305	ALAS1/PSPH/DLD/GLYCTK	-1.91415837976492
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/2076	18/9376	0.250909869406979	NEU1	-1.69635479235027
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/2076	79/9376	0.571693373332358	ATP6V1C1/NSF/CLTC/ATP6V0A1/ATP6V1G1/SLC17A7/UNC13B/CLTA/ATP6V1E2/AP2M1	-2.03861308131069
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/2076	61/9376	0.51827284500458	TRPM7/HEPH/MT1E/SLC30A1/ATP1A1/MT1X/MT2A	-2.01285503745893
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/2076	88/9376	0.564547206165703	CFI/CD46/F8/PROS1/PROCR/CFH/THBD/SERPINA5/C1R/CFB/CD55	-2.18856372567467
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/2076	44/9376	0.41057978630233	HSPD1/PTPRN2/HLA-F/IL12A	-2.08978631787157
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2076	30/9376	0.301091843288375	PLA2G4C/PLA2G4A	-2.04458763853277
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/2076	66/9376	0.479009750686051	HSD17B11/HSD17B7/SRD5A3/LRTOMT/HSD17B12/AKR1C3/COMT	-2.26498121916082
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/2076	79/9376	0.514524035999122	GSTM3/MGST2/EPHX1/GSTA4/GSTO1/GSTK1/AKR7A2/CBR1/MGST3	-2.31072224722335
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/2076	23/9376	0.196364245622853	B4GALT1	-2.05771670915342
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/2076	100/9376	0.541965317919075	CXCL2/CXCL1/ACKR3/TNFRSF10D/CXCL3/TNFRSF1A/TNFRSF10B/TNFSF10/CXCL8/CSF1/IL6ST/CCL21	-2.4555901151535
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2076	41/9376	0.330466657267729	GABRE/GRIN2B/SLC17A7	-2.29110429610273
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/2076	43/9376	0.31509611506923	CD36/GOT2/ACAT2	-2.40044139379096
Organismal Systems	Sensory system	hsa04742	Taste transduction	9/2076	86/9376	0.472644172603845	SCN9A/PDE1A/ADCY4/PLCB1/SCN3A/PLCB4/PRKACB/ADCY6/ITPR3	-2.6198896596139
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/2076	73/9376	0.433077308839444	GSTM3/MGST2/FMO5/GSTA4/GSTO1/GSTK1/MGST3	-2.59305448577056
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/2076	36/9376	0.250909869406979	RPE/UGP2	-2.40131851914678
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/2076	87/9376	0.46721148096472	ATP2A2/ASPH/UQCRC2/UQCRFS1/ATP1A1/COX7A2L/UQCRH/TPM4/COX7B	-2.66236677781469
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/2076	39/9376	0.231609110221827	HLA-F/IL12A	-2.56418121327643
Human Diseases	Immune disease	hsa05310	Asthma	1/2076	32/9376	0.141136801541426	FCER1A	-2.59519772011318
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	25/2076	195/9376	0.579022775554567	PIK3CA/HAT1/CASP4/PRKCA/PLCB1/VDAC3/CASP1/NFKB1/VDAC2/PLCB4/HDAC1/VDAC1/HDAC8/AKT1/SLC25A5/MAPK1/MAP3K7/MAP2K2/PIK3R3/RELA/HDAC5/MAP2K1/MTOR/MAPK12/AGER	-3.16788053312104
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/2076	90/9376	0.401455791051167	ADCY4/GNAS/HMGCR/EPHX1/PRKACB/ATP1A1/KCNN2/ADCY6	-3.04257316851567
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/2076	160/9376	0.508092485549133	SDC4/ITGAV/NECTIN3/F11R/ITGA9/CLDN5/CD99/PECAM1/NCAM1/CDH5/HLA-F/PTPRM/OCLN/NEO1/CLDN14/CD274/CLDN12/ESAM	-3.34664847968816
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	30/2076	233/9376	0.581507851844501	CSRP2/ITGA2/SDC4/MYH10/TMOD2/CAPZA2/PDLIM3/SGCE/LBR/ITGAV/DSP/TMOD3/FHL1/SUN1/ITGA9/ANK2/COL4A1/SGCB/ELN/SPTAN1/TMEM43/COL9A3/FLNC/SGCD/ATP1A1/ITGA1/TTN/TPM4/SNTB2/SPTBN1	-3.44952103369185
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/2076	254/9376	0.586773474124983	CAMK2D/HGF/PDE1A/EDNRB/ADCY4/PRKCA/GNAS/NFATC1/FLT4/PLCB1/PPP3R1/VDAC3/ATP2A2/PPP3CC/ASPH/PPP3CA/STIM2/ADRB2/VDAC2/KDR/ORAI3/PLCB4/VDAC1/GRIN2B/PLCE1/ITPR1/CALM1/SLC25A5/PRKACB/PPP3CB/CALML4/ITPR3/MYLK	-3.56039267690613
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/2076	68/9376	0.265669273489743	ALDH1A1/DHRS4L2/RDH11/DHRS4	-3.24082703062874
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/2076	100/9376	0.36131021194605	CD36/IL7/ITGA2/ITGA1/CSF1/IL3RA/KITLG/CD55	-3.42410824234848
NA	NA	hsa04382	Cornified envelope formation	26/2076	217/9376	0.541132805909983	PPP2R5A/PCSK6/DSP/PPP2R3C/PPP2R2D/SPTLC2/COL4A1/CLDN5/PPP2R5C/PPP2CB/PPP2CA/SPTLC1/ELOVL1/PPP2R2A/ABHD5/PPP2R1B/OCLN/PPP2R5E/BLMH/S100A10/CLDN14/PPP2R5B/CLDN12/EPHX2/LAMC2/TJP1	-3.64695773134671
NA	NA	hsa04082	Neuroactive ligand signaling	23/2076	199/9376	0.521993396655726	GABRE/GNAI3/GNB4/ADCY4/PRKCA/GNAS/PLCB1/OGFR/GNG12/ADRB2/PLCB4/GNG5/GNG11/GRIN2B/PRKACB/GNGT2/ACHE/SLC17A7/GRIK1/GNG10/OGFRL1/ADCY6/GNAI2	-3.63452743311258
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/2076	103/9376	0.350786613539854	SLC38A2/COL4A1/ELN/COL9A3/SLC36A4/ATP1A1/COL8A1/COL8A2	-3.53292022826836
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/2076	45/9376	0.100363947762792	HLA-F	-3.22587025518581
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/2076	50/9376	0.0903275529865125	IL15RA	-3.43922207704863
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/2076	54/9376	0.0836366231356597	HLA-F	-3.60120576991432
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	32/2076	298/9376	0.484980150263154	CXCL2/CXCL1/IL7/ACKR3/LIF/IFNGR1/TGFBR2/TNFRSF10D/IFNGR2/BMP2/CXCL3/TNFRSF1A/TNFRSF10B/TGFB3/IFNAR1/TNFSF12/IL15RA/TNFSF10/CXCL8/RELL1/RELT/ACVR1B/CSF1/IL6ST/IL3RA/IL12A/TSLP/GDF3/TNFSF9/IL13RA1/CCL21/ACVR1	-4.81808983564157
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/2076	99/9376	0.182479905023258	CFI/CFH/C1R/CFB	-4.36063903696917
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/2076	143/9376	0.126332241939178	TRIM21/GRIN2B/SSB/C1R	-5.6141083803348
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/2076	370/9376	0.183096391188877	CALCRL/GABRE/PGRMC1/EDNRB/LPAR6/OGFR/NR3C1/S1PR1/ADRB2/THRA/GRIN2B/GRIK1/AVPR2/OGFRL1/VIP	-8.54955652710366
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/2076	449/9376	0.0704112328402659	CAMK2D/PDE1A/NCALD/ARRB1/CALM1/PRKACB/CALML4	-10.7646311433953