ID	Description	GeneRatio	BgRatio	RichFactor	FoldEnrichment	pvalue	p.adjust
GO:0019787	ubiquitin-like protein transferase activity	207/4447	479/18639	0.432150313152401	1.81129968222343	2.9529296832077e-21	3.91853768961662e-18
GO:0016755	aminoacyltransferase activity	209/4447	496/18639	0.421370967741935	1.76611951152281	7.00775549873617e-20	4.64964577341145e-17
GO:0003712	transcription coregulator activity	207/4447	495/18639	0.418181818181818	1.75275262178793	3.02244935206316e-19	1.33693009672927e-16
GO:0004842	ubiquitin-protein transferase activity	191/4447	449/18639	0.425389755011136	1.78296371568531	8.38539563068162e-19	2.78185500047863e-16
GO:0061659	ubiquitin-like protein ligase activity	148/4447	372/18639	0.397849462365591	1.66753229796093	4.26645389712172e-12	1.1323168642961e-09
GO:0140297	DNA-binding transcription factor binding	179/4447	488/18639	0.366803278688525	1.53740641139541	8.99805976330532e-11	1.82001500782163e-08
GO:0061630	ubiquitin protein ligase activity	138/4447	353/18639	0.390934844192635	1.63855060960344	9.6006820307094e-11	1.82001500782163e-08
GO:0003713	transcription coactivator activity	106/4447	256/18639	0.4140625	1.73548705588037	3.20999754397038e-10	5.32458342606087e-08
GO:0000287	magnesium ion binding	97/4447	230/18639	0.421739130434783	1.76766261573508	5.52940162553815e-10	7.70016380730127e-08
GO:0044389	ubiquitin-like protein ligase binding	126/4447	322/18639	0.391304347826087	1.64009933418719	5.80268561213358e-10	7.70016380730127e-08
GO:0043021	ribonucleoprotein complex binding	77/4447	177/18639	0.435028248587571	1.82336215997835	6.22447799995066e-09	7.05095034998463e-07
GO:0051082	unfolded protein binding	58/4447	121/18639	0.479338842975207	2.00908403287944	6.37614198943599e-09	7.05095034998463e-07
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	130/4447	349/18639	0.372492836676218	1.56125342541219	1.1540334132526e-08	1.17800179952785e-06
GO:0031625	ubiquitin protein ligase binding	115/4447	302/18639	0.380794701986755	1.59604957282013	1.96179628900624e-08	1.8595026253652e-06
GO:0106310	protein serine kinase activity	132/4447	361/18639	0.365650969529086	1.53257666315553	3.25705837203936e-08	2.88141097313082e-06
GO:0061650	ubiquitin-like protein conjugating enzyme activity	26/4447	41/18639	0.634146341463415	2.65793875838466	8.13406207135119e-08	6.7461877304269e-06
GO:0140098	catalytic activity, acting on RNA	138/4447	387/18639	0.356589147286822	1.49459525888893	9.21735526218778e-08	7.19495907819011e-06
GO:0003697	single-stranded DNA binding	55/4447	121/18639	0.454545454545455	1.90516589324775	1.50665236735669e-07	1.11073760637907e-05
GO:0004532	RNA exonuclease activity	25/4447	40/18639	0.625	2.61960310321565	2.18632021383854e-07	1.52697206513881e-05
GO:0004674	protein serine/threonine kinase activity	148/4447	433/18639	0.341801385681293	1.4326143529826	6.08823720928664e-07	4.03954538836169e-05
GO:0140662	ATP-dependent protein folding chaperone	24/4447	40/18639	0.6	2.51481897908702	1.12069324999979e-06	7.0817140130939e-05
GO:0016922	nuclear receptor binding	58/4447	137/18639	0.423357664233577	1.77444648159425	1.31118275564208e-06	7.90881598516835e-05
GO:0140994	RNA polymerase II CTD heptapeptide repeat modifying activity	55/4447	128/18639	0.4296875	1.80097713346076	1.39520372967622e-06	8.04971890991454e-05
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	23/4447	38/18639	0.605263157894737	2.53687879469305	1.51301271548742e-06	8.36569947271588e-05
GO:0005525	GTP binding	130/4447	378/18639	0.343915343915344	1.44147472346258	2.00319896369282e-06	0.000106329800992815
GO:0031072	heat shock protein binding	55/4447	131/18639	0.419847328244275	1.7597333823128	3.31246244394067e-06	0.000169062987042664
GO:0140030	modification-dependent protein binding	68/4447	173/18639	0.393063583815029	1.64747293427666	4.13237984514238e-06	0.000203098816833479
GO:0019003	GDP binding	36/4447	75/18639	0.48	2.01185518326962	4.37862490029886e-06	0.000207515544382021
GO:0000175	3'-5'-RNA exonuclease activity	21/4447	35/18639	0.6	2.51481897908702	5.28050283598882e-06	0.000233574242111905
GO:0061631	ubiquitin conjugating enzyme activity	21/4447	35/18639	0.6	2.51481897908702	5.28050283598882e-06	0.000233574242111905
GO:0003714	transcription corepressor activity	76/4447	204/18639	0.372549019607843	1.56148890858345	1.17691950329895e-05	0.0004952935107736
GO:0002039	p53 binding	33/4447	69/18639	0.478260869565217	2.00456585289546	1.19437772002677e-05	0.0004952935107736
GO:0019887	protein kinase regulator activity	91/4447	255/18639	0.356862745098039	1.49574200716941	1.29911882426808e-05	0.000519522704403759
GO:0140517	protein-RNA adaptor activity	15/4447	22/18639	0.681818181818182	2.85774883987162	1.33110564805786e-05	0.000519522704403759
GO:0035173	histone kinase activity	121/4447	360/18639	0.336111111111111	1.40876433550708	1.52881904257881e-05	0.000544248413506542
GO:0016887	ATP hydrolysis activity	137/4447	417/18639	0.328537170263789	1.37701918519154	1.59708294424683e-05	0.000544248413506542
GO:0140857	histone H3T45 kinase activity	88/4447	246/18639	0.357723577235772	1.49935006883237	1.60944953770076e-05	0.000544248413506542
GO:0140097	catalytic activity, acting on DNA	114/4447	336/18639	0.339285714285714	1.42207025603135	1.66408028448596e-05	0.000544248413506542
GO:0043022	ribosome binding	47/4447	112/18639	0.419642857142857	1.75887636930194	1.68669990840467e-05	0.000544248413506542
GO:0051087	protein-folding chaperone binding	54/4447	134/18639	0.402985074626866	1.6890575232674	1.69281345952822e-05	0.000544248413506542
GO:0035403	histone H3T6 kinase activity	88/4447	247/18639	0.356275303643725	1.49327982563872	1.92168605303683e-05	0.000544248413506542
GO:0042393	histone binding	88/4447	247/18639	0.356275303643725	1.49327982563872	1.92168605303683e-05	0.000544248413506542
GO:0008094	ATP-dependent activity, acting on DNA	77/4447	210/18639	0.366666666666667	1.53683382055318	1.98962817441014e-05	0.000544248413506542
GO:0004676	3-phosphoinositide-dependent protein kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0004711	ribosomal protein S6 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0035175	histone H3S10 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0035979	histone H2AXS139 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0044022	histone H3S28 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0044023	histone H4S1 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0044024	histone H2AS1 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0044025	histone H2BS14 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0072354	histone H3T3 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0072371	histone H2AS121 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0072518	Rho-dependent protein serine/threonine kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0140823	histone H2BS36 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0140855	histone H3S57 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0140995	histone H2A kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0140997	histone H4 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0140998	histone H2B kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:1990244	histone H2AT120 kinase activity	87/4447	245/18639	0.355102040816327	1.48836225292906	2.46080669256914e-05	0.000544248413506542
GO:0003727	single-stranded RNA binding	39/4447	89/18639	0.438202247191011	1.83666554652423	2.64789728758554e-05	0.000574960369271058
GO:0032182	ubiquitin-like protein binding	49/4447	120/18639	0.408333333333333	1.71147402743423	2.70358838425629e-05	0.000574960369271058
GO:0140996	histone H3 kinase activity	119/4447	357/18639	0.333333333333333	1.39712165504835	2.72965359940291e-05	0.000574960369271058
GO:0004677	DNA-dependent protein kinase activity	87/4447	246/18639	0.353658536585366	1.48231199986837	2.92664362636502e-05	0.000600961278118541
GO:0141003	histone H2AX kinase activity	118/4447	354/18639	0.333333333333333	1.39712165504835	2.94366865694839e-05	0.000600961278118541
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	86/4447	243/18639	0.353909465020576	1.48336373252047	3.14684795365997e-05	0.000632707156743452
GO:0019783	ubiquitin-like protein peptidase activity	51/4447	127/18639	0.401574803149606	1.68314656080628	3.2026972386008e-05	0.000634325259048248
GO:0060590	ATPase regulator activity	25/4447	49/18639	0.510204081632653	2.1384515128291	3.41201765366164e-05	0.000660079463278384
GO:0035402	histone H3T11 kinase activity	87/4447	247/18639	0.352226720647773	1.47631073671101	3.47308930686221e-05	0.000660079463278384
GO:0045296	cadherin binding	112/4447	334/18639	0.335329341317365	1.40548765298277	3.48195647547e-05	0.000660079463278384
GO:0004679	AMP-activated protein kinase activity	87/4447	248/18639	0.350806451612903	1.47035787083717	4.11268965626407e-05	0.000768667489276397
GO:0019001	guanyl nucleotide binding	130/4447	400/18639	0.325	1.36219361367214	4.56898402651323e-05	0.000830553671668911
GO:0032561	guanyl ribonucleotide binding	130/4447	400/18639	0.325	1.36219361367214	4.56898402651323e-05	0.000830553671668911
GO:0019207	kinase regulator activity	98/4447	287/18639	0.341463414634146	1.43119779297636	4.75351799007607e-05	0.000852421401733911
GO:0140597	protein carrier chaperone	69/4447	188/18639	0.367021276595745	1.53832012018621	5.04256332063406e-05	0.000892197536864185
GO:0140767	enzyme-substrate adaptor activity	54/4447	139/18639	0.388489208633094	1.62830005840167	5.62287233808716e-05	0.000981783104294955
GO:0070063	RNA polymerase binding	28/4447	59/18639	0.474576271186441	1.98912235634002	6.39440438105759e-05	0.00110199670307317
GO:0060589	nucleoside-triphosphatase regulator activity	154/4447	490/18639	0.314285714285714	1.31728613190273	6.65547558086726e-05	0.00113228411484755
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	62/4447	167/18639	0.37125748502994	1.55607561580235	8.06891634021513e-05	0.0013368196363025
GO:0004535	poly(A)-specific ribonuclease activity	10/4447	13/18639	0.769230769230769	3.22412689626542	8.17259782432082e-05	0.0013368196363025
GO:0140852	histone ubiquitin ligase activity	10/4447	13/18639	0.769230769230769	3.22412689626542	8.17259782432082e-05	0.0013368196363025
GO:0051059	NF-kappaB binding	18/4447	32/18639	0.5625	2.35764279289409	8.26067898845553e-05	0.0013368196363025
GO:0140537	transcription regulator activator activity	9/4447	11/18639	0.818181818181818	3.42929860784594	8.45692594987835e-05	0.00134918750774277
GO:0001221	transcription coregulator binding	46/4447	115/18639	0.4	1.67654598605802	8.5404484288163e-05	0.00134918750774277
GO:0030695	GTPase regulator activity	153/4447	489/18639	0.312883435582822	1.31140867007606	8.9515404052667e-05	0.00139749342562223
GO:0004527	exonuclease activity	36/4447	84/18639	0.428571428571429	1.79629927077645	9.35278383466274e-05	0.00144315629634854
GO:0003725	double-stranded RNA binding	33/4447	75/18639	0.44	1.84420058466382	9.74577328272401e-05	0.00146961831206531
GO:0044183	protein folding chaperone	33/4447	75/18639	0.44	1.84420058466382	9.74577328272401e-05	0.00146961831206531
GO:0004386	helicase activity	58/4447	155/18639	0.374193548387097	1.56838172889298	0.000104884684040817	0.00156384242384454
GO:0140674	ATP-dependent histone chaperone activity	57/4447	152/18639	0.375	1.57176186192939	0.000111891553624148	0.00164977879621383
GO:0017025	TBP-class protein binding	15/4447	25/18639	0.6	2.51481897908702	0.00012062933132053	0.00175906728200377
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	35/4447	82/18639	0.426829268292683	1.78899724122044	0.000128369455086829	0.00185158985761111
GO:0008170	N-methyltransferase activity	40/4447	98/18639	0.408163265306122	1.71076121026328	0.000143953469394873	0.0020350932935792
GO:0008168	methyltransferase activity	72/4447	204/18639	0.352941176470588	1.4793052818159	0.000146281092381279	0.0020350932935792
GO:0003689	DNA clamp loader activity	59/4447	160/18639	0.36875	1.54556583089723	0.000146835629414533	0.0020350932935792
GO:0140104	molecular carrier activity	85/4447	249/18639	0.34136546184739	1.43078723709771	0.000147226040831652	0.0020350932935792
GO:0046966	nuclear thyroid hormone receptor binding	16/4447	28/18639	0.571428571428571	2.3950656943686	0.000159972240517864	0.00218848621821861
GO:0000993	RNA polymerase II complex binding	19/4447	36/18639	0.527777777777778	2.21210928715988	0.000165865748953215	0.00224595764143792
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	35/4447	83/18639	0.421686746987952	1.76744305759128	0.000171512603901475	0.0022920395057335
GO:0140296	general transcription initiation factor binding	25/4447	53/18639	0.471698113207547	1.97705894582313	0.000175707744142378	0.0022920395057335
GO:0000510	H3-H4 histone complex chaperone activity	56/4447	151/18639	0.370860927152318	1.55441349700743	0.000179632335038647	0.0022920395057335
GO:0140584	chromatin extrusion motor activity	56/4447	151/18639	0.370860927152318	1.55441349700743	0.000179632335038647	0.0022920395057335
GO:0140665	ATP-dependent H3-H4 histone complex chaperone activity	56/4447	151/18639	0.370860927152318	1.55441349700743	0.000179632335038647	0.0022920395057335
GO:0140849	ATP-dependent H2AZ histone chaperone activity	56/4447	151/18639	0.370860927152318	1.55441349700743	0.000179632335038647	0.0022920395057335
GO:0140658	ATP-dependent chromatin remodeler activity	58/4447	158/18639	0.367088607594937	1.53860232897729	0.000191195757397973	0.00241635019111533
GO:0005085	guanyl-nucleotide exchange factor activity	79/4447	230/18639	0.343478260869565	1.43964274889764	0.000197868799334265	0.00247709336525065
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	47/4447	122/18639	0.385245901639344	1.61470617509686	0.000207933631154996	0.00257876568731476
GO:0019210	kinase inhibitor activity	37/4447	90/18639	0.411111111111111	1.72311670789296	0.000211406442275699	0.00259391625555955
GO:0015616	DNA translocase activity	56/4447	152/18639	0.368421052631579	1.54418709242186	0.000219147790863773	0.00259391625555955
GO:1990825	sequence-specific mRNA binding	10/4447	14/18639	0.714285714285714	2.99383211796074	0.000224541236387661	0.00259391625555955
GO:0016791	phosphatase activity	91/4447	273/18639	0.333333333333333	1.39712165504835	0.000226846219011919	0.00259391625555955
GO:0004860	protein kinase inhibitor activity	35/4447	84/18639	0.416666666666667	1.74640206881043	0.000227216007869226	0.00259391625555955
GO:0033192	calmodulin-dependent protein phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0140791	histone H2AXS140 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0180004	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0180005	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0180006	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0180007	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0180008	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:1990439	MAP kinase serine/threonine phosphatase activity	34/4447	81/18639	0.419753086419753	1.75933838043125	0.000234566654609756	0.00259391625555955
GO:0001098	basal transcription machinery binding	27/4447	60/18639	0.45	1.88611423431527	0.000260723251304341	0.00281284353236472
GO:0001099	basal RNA polymerase II transcription machinery binding	27/4447	60/18639	0.45	1.88611423431527	0.000260723251304341	0.00281284353236472
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	27/4447	60/18639	0.45	1.88611423431527	0.000260723251304341	0.00281284353236472
GO:0061775	cohesin loader activity	56/4447	153/18639	0.366013071895425	1.5340943663276	0.000266361519500765	0.00285049787401222
GO:0033549	MAP kinase phosphatase activity	34/4447	82/18639	0.414634146341463	1.73788303432843	0.000309789670938496	0.00328872714668307
GO:0140713	histone chaperone activity	59/4447	164/18639	0.359756097560976	1.50786910331437	0.000314243263300956	0.00330953024127277
GO:0008276	protein methyltransferase activity	38/4447	95/18639	0.4	1.67654598605802	0.000339135234997462	0.00354356265229632
GO:0008408	3'-5' exonuclease activity	26/4447	58/18639	0.448275862068966	1.87888774299605	0.000362799278829319	0.00376120814848833
GO:0010485	histone H4 acetyltransferase activity	18/4447	35/18639	0.514285714285714	2.15555912493174	0.000374144681584278	0.00384875963149099
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	13/4447	22/18639	0.590909090909091	2.47671566122207	0.000427194210529804	0.00436066705671577
GO:0008234	cysteine-type peptidase activity	65/4447	187/18639	0.347593582887701	1.45689156542475	0.000481726923785746	0.00487978341880676
GO:0140789	histone phosphatase activity	50/4447	136/18639	0.367647058823529	1.54094300189156	0.00048951697657568	0.00490516479533165
GO:0004722	protein serine/threonine phosphatase activity	40/4447	103/18639	0.388349514563107	1.62771454957089	0.000492186066165143	0.00490516479533165
GO:0016741	transferase activity, transferring one-carbon groups	73/4447	215/18639	0.33953488372093	1.4231146160725	0.000495321840674033	0.00490516479533165
GO:0017018	myosin phosphatase activity	34/4447	84/18639	0.404761904761905	1.69650486684442	0.000527131314257325	0.00518150558532941
GO:0044390	ubiquitin-like protein conjugating enzyme binding	18/4447	36/18639	0.5	2.09568248257252	0.000582423614215342	0.0056829127651747
GO:0003924	GTPase activity	105/4447	331/18639	0.317220543806647	1.32958707353544	0.000622932014597512	0.00603380133847371
GO:0004721	phosphoprotein phosphatase activity	61/4447	175/18639	0.348571428571429	1.46099007356484	0.000650022239394571	0.00623403873868789
GO:0004402	histone acetyltransferase activity	20/4447	42/18639	0.476190476190476	1.9958880786405	0.000657698133697291	0.00623403873868789
GO:0043175	RNA polymerase core enzyme binding	20/4447	42/18639	0.476190476190476	1.9958880786405	0.000657698133697291	0.00623403873868789
GO:0003925	G protein activity	24/4447	54/18639	0.444444444444444	1.8628288733978	0.00070243313310658	0.00656428709600304
GO:0140463	chromatin-protein adaptor activity	24/4447	54/18639	0.444444444444444	1.8628288733978	0.00070243313310658	0.00656428709600304
GO:0101005	deubiquitinase activity	43/4447	115/18639	0.373913043478261	1.56720603044554	0.000786066281326119	0.00729447521202629
GO:0051020	GTPase binding	100/4447	315/18639	0.317460317460317	1.330592052427	0.0008034120632189	0.00740366533257973
GO:0070990	snRNP binding	8/4447	11/18639	0.727272727272727	3.04826542919639	0.000846572858320082	0.00774760126200516
GO:0031267	small GTPase binding	91/4447	283/18639	0.321554770318021	1.34775339868621	0.000859518391068913	0.00781219797909896
GO:0035591	signaling adaptor activity	47/4447	129/18639	0.364341085271318	1.52708646016912	0.000889835985650157	0.00803273709495074
GO:0015036	disulfide oxidoreductase activity	19/4447	40/18639	0.475	1.99089835844389	0.00092668894465353	0.00830889344294077
GO:0004518	nuclease activity	70/4447	209/18639	0.334928229665072	1.40380644765623	0.000973105271553046	0.0086665147338986
GO:0001222	transcription corepressor binding	22/4447	49/18639	0.448979591836735	1.88183733128961	0.000979891303726461	0.00866877173363342
GO:0003724	RNA helicase activity	31/4447	77/18639	0.402597402597403	1.68743264830515	0.00101168514784903	0.00889076947811694
GO:0010484	histone H3 acetyltransferase activity	15/4447	29/18639	0.517241379310345	2.16794739576468	0.00106038821107564	0.00925746813221955
GO:0043130	ubiquitin binding	38/4447	100/18639	0.38	1.59271868675512	0.00108768295259022	0.00943369462802104
GO:0070717	poly-purine tract binding	16/4447	32/18639	0.5	2.09568248257252	0.00116735014167921	0.0100589197273267
GO:0004540	RNA nuclease activity	44/4447	121/18639	0.363636363636364	1.5241327145982	0.00133346383351508	0.0114161710133839
GO:0061733	protein-lysine-acetyltransferase activity	21/4447	47/18639	0.446808510638298	1.872737537618	0.0013680587228199	0.0116372687511667
GO:0004725	protein tyrosine phosphatase activity	37/4447	98/18639	0.377551020408163	1.58245411949354	0.00143928801005068	0.0121651922887723
GO:0008474	palmitoyl-(protein) hydrolase activity	9/4447	14/18639	0.642857142857143	2.69444890616467	0.0015029405313741	0.0123902930130596
GO:0098599	palmitoyl hydrolase activity	9/4447	14/18639	0.642857142857143	2.69444890616467	0.0015029405313741	0.0123902930130596
GO:0001671	ATPase activator activity	14/4447	27/18639	0.518518518518518	2.17330035229743	0.00150517680269072	0.0123902930130596
GO:0008080	N-acetyltransferase activity	28/4447	69/18639	0.405797101449275	1.7008437539719	0.00150617844753229	0.0123902930130596
GO:1990380	K48-linked deubiquitinase activity	11/4447	19/18639	0.578947368421053	2.42657971666292	0.00151260547710298	0.0123902930130596
GO:0031624	ubiquitin conjugating enzyme binding	15/4447	30/18639	0.5	2.09568248257252	0.00165642746267581	0.0130924797101034
GO:0043995	histone H4K5 acetyltransferase activity	15/4447	30/18639	0.5	2.09568248257252	0.00165642746267581	0.0130924797101034
GO:0043996	histone H4K8 acetyltransferase activity	15/4447	30/18639	0.5	2.09568248257252	0.00165642746267581	0.0130924797101034
GO:0043997	histone H4K12 acetyltransferase activity	15/4447	30/18639	0.5	2.09568248257252	0.00165642746267581	0.0130924797101034
GO:0008186	ATP-dependent activity, acting on RNA	31/4447	79/18639	0.392405063291139	1.644712834424	0.00165752569050292	0.0130924797101034
GO:0046332	SMAD binding	31/4447	79/18639	0.392405063291139	1.644712834424	0.00165752569050292	0.0130924797101034
GO:0016779	nucleotidyltransferase activity	48/4447	136/18639	0.352941176470588	1.4793052818159	0.00172083914221537	0.0135121511344367
GO:0140034	methylation-dependent protein binding	30/4447	76/18639	0.394736842105263	1.65448617045199	0.00175179370728769	0.0136742955857104
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	23/4447	54/18639	0.425925925925926	1.78521100367289	0.00181483497947647	0.0140835439635396
GO:0003743	translation initiation factor activity	22/4447	51/18639	0.431372549019608	1.8080397888861	0.00185870168168215	0.0142666464969547
GO:0046972	histone H4K16 acetyltransferase activity	12/4447	22/18639	0.545454545454545	2.2861990718973	0.00185993206026614	0.0142666464969547
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	21/4447	48/18639	0.4375	1.83372217225096	0.00189151336587311	0.0144139292906545
GO:0016407	acetyltransferase activity	36/4447	96/18639	0.375	1.57176186192939	0.00190085729153319	0.0144139292906545
GO:0016278	lysine N-methyltransferase activity	28/4447	70/18639	0.4	1.67654598605802	0.00194647908569453	0.0146760099245264
GO:0008135	translation factor activity, RNA binding	32/4447	83/18639	0.385542168674699	1.61594793836917	0.00197379453010668	0.0147978832850371
GO:0043047	single-stranded telomeric DNA binding	8/4447	12/18639	0.666666666666667	2.79424331009669	0.00200741342775055	0.0148817744057261
GO:1990247	N6-methyladenosine-containing RNA reader activity	8/4447	12/18639	0.666666666666667	2.79424331009669	0.00200741342775055	0.0148817744057261
GO:0000049	tRNA binding	31/4447	80/18639	0.3875	1.6241539239937	0.00209653240071497	0.0154525328255063
GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	10/4447	17/18639	0.588235294117647	2.46550880302649	0.00211933758420659	0.0154525328255063
GO:0004659	prenyltransferase activity	10/4447	17/18639	0.588235294117647	2.46550880302649	0.00211933758420659	0.0154525328255063
GO:0019211	phosphatase activator activity	13/4447	25/18639	0.52	2.17950978187542	0.00214052145240243	0.015521704739552
GO:0036408	histone H3K14 acetyltransferase activity	14/4447	28/18639	0.5	2.09568248257252	0.00235463400931446	0.0167090873281299
GO:0051537	2 iron, 2 sulfur cluster binding	14/4447	28/18639	0.5	2.09568248257252	0.00235463400931446	0.0167090873281299
GO:0097718	disordered domain specific binding	14/4447	28/18639	0.5	2.09568248257252	0.00235463400931446	0.0167090873281299
GO:0141052	histone H3 demethylase activity	14/4447	28/18639	0.5	2.09568248257252	0.00235463400931446	0.0167090873281299
GO:0180051	translation factor activity	32/4447	84/18639	0.380952380952381	1.5967104629124	0.0024698343929392	0.0174333523373953
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	7/4447	10/18639	0.7	2.93395547560153	0.00261759154196879	0.0181860941161915
GO:0016303	1-phosphatidylinositol-3-kinase activity	7/4447	10/18639	0.7	2.93395547560153	0.00261759154196879	0.0181860941161915
GO:0098505	G-rich strand telomeric DNA binding	7/4447	10/18639	0.7	2.93395547560153	0.00261759154196879	0.0181860941161915
GO:0004712	protein serine/threonine/tyrosine kinase activity	19/4447	43/18639	0.441860465116279	1.85199847297107	0.00266773609653537	0.0184379468755335
GO:0004843	cysteine-type deubiquitinase activity	39/4447	108/18639	0.361111111111111	1.51354845963571	0.00279735802479365	0.0192336481808351
GO:0000774	adenyl-nucleotide exchange factor activity	9/4447	15/18639	0.6	2.51481897908702	0.00296361039429807	0.0202717061506883
GO:0044013	histone H2B acetyltransferase activity	12/4447	23/18639	0.521739130434783	2.18679911224959	0.003050579211792	0.0207595826361435
GO:0034212	protein N-acetyltransferase activity	22/4447	53/18639	0.415094339622642	1.73981187232436	0.00333110456963427	0.0225529375709422
GO:0016279	protein-lysine N-methyltransferase activity	27/4447	69/18639	0.391304347826087	1.64009933418719	0.00335603882098762	0.0226064137840131
GO:0035091	phosphatidylinositol binding	88/4447	284/18639	0.309859154929577	1.29873280610128	0.00345244424201069	0.023138351056304
GO:0140566	histone reader activity	16/4447	35/18639	0.457142857142857	1.91605255549488	0.00375224348923807	0.0247858906833303
GO:0000900	mRNA regulatory element binding translation repressor activity	10/4447	18/18639	0.555555555555556	2.32853609174725	0.00375430597388801	0.0247858906833303
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	10/4447	18/18639	0.555555555555556	2.32853609174725	0.00375430597388801	0.0247858906833303
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	24/4447	60/18639	0.4	1.67654598605802	0.00396189034369557	0.0260268736934853
GO:0043539	protein serine/threonine kinase activator activity	28/4447	73/18639	0.383561643835616	1.60764683594604	0.00398309288072613	0.0260372623286876
GO:0140666	annealing activity	8/4447	13/18639	0.615384615384615	2.57930151701233	0.00412949505108177	0.0268619604548309
GO:0017069	snRNA binding	22/4447	54/18639	0.407407407407407	1.70759313394798	0.0043735399128678	0.0283106705579296
GO:0043998	histone H2A acetyltransferase activity	12/4447	24/18639	0.5	2.09568248257252	0.00478898097587993	0.0308494065776343
GO:0140101	catalytic activity, acting on a tRNA	47/4447	139/18639	0.338129496402878	1.41722412490516	0.00496407501513668	0.0315764716601411
GO:0031491	nucleosome binding	28/4447	74/18639	0.378378378378378	1.58592187870353	0.00497323479801769	0.0315764716601411
GO:0035064	methylated histone binding	28/4447	74/18639	0.378378378378378	1.58592187870353	0.00497323479801769	0.0315764716601411
GO:0051879	Hsp90 protein binding	18/4447	42/18639	0.428571428571429	1.79629927077645	0.00508690738397845	0.0321444099930448
GO:0015631	tubulin binding	114/4447	385/18639	0.296103896103896	1.24107949617282	0.00518778411449619	0.0326264906158125
GO:0032452	histone demethylase activity	14/4447	30/18639	0.466666666666667	1.95597031706769	0.0052304948845412	0.0327399373197461
GO:0140416	transcription regulator inhibitor activity	15/4447	33/18639	0.454545454545455	1.90516589324775	0.00529248972894595	0.0329724594850295
GO:0030145	manganese ion binding	26/4447	68/18639	0.382352941176471	1.60258072196722	0.00567284417251669	0.0351769355931292
GO:0032404	mismatch repair complex binding	7/4447	11/18639	0.636363636363636	2.66723225054684	0.00571687423835404	0.0352850796013758
GO:0005096	GTPase activator activity	83/4447	271/18639	0.306273062730627	1.28370218489682	0.00615596155486069	0.0378192638115747
GO:0050145	nucleoside monophosphate kinase activity	10/4447	19/18639	0.526315789473684	2.20598156060265	0.00624508430364914	0.0381749184456979
GO:0016763	pentosyltransferase activity	20/4447	49/18639	0.408163265306122	1.71076121026328	0.00627138826010711	0.0381749184456979
GO:0016853	isomerase activity	58/4447	180/18639	0.322222222222222	1.3505509332134	0.0064323832632698	0.0388847222418249
GO:0000149	SNARE binding	37/4447	106/18639	0.349056603773585	1.46302361990912	0.00668281448204142	0.0388847222418249
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	32/4447	89/18639	0.359550561797753	1.50700762791732	0.00685020333648503	0.0388847222418249
GO:0030946	protein tyrosine phosphatase activity, metal-dependent	32/4447	89/18639	0.359550561797753	1.50700762791732	0.00685020333648503	0.0388847222418249
GO:0032931	histone H3K56 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0043992	histone H3K9 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0043993	histone H3K18 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0043994	histone H3K23 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0043999	histone H2AK5 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044012	histone H2AK9 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044014	histone H2BK5 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044015	histone H2BK12 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044016	histone H3K4 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044017	histone H3K27 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0044018	histone H3K36 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0140908	histone H3K122 acetyltransferase activity	11/4447	22/18639	0.5	2.09568248257252	0.00685683873744313	0.0388847222418249
GO:0019208	phosphatase regulator activity	40/4447	117/18639	0.341880341880342	1.43294528722907	0.00735668507057953	0.0415417918666342
GO:0015035	protein-disulfide reductase activity	15/4447	34/18639	0.441176470588235	1.84913160226987	0.00741196400422479	0.0416649311450836
GO:0070273	phosphatidylinositol-4-phosphate binding	14/4447	31/18639	0.451612903225806	1.89287450038808	0.00747268546535787	0.0416649311450836
GO:0140457	protein demethylase activity	14/4447	31/18639	0.451612903225806	1.89287450038808	0.00747268546535787	0.0416649311450836
GO:0030983	mismatched DNA binding	8/4447	14/18639	0.571428571428571	2.3950656943686	0.00763156774402533	0.0421962099846734
GO:0098847	sequence-specific single stranded DNA binding	8/4447	14/18639	0.571428571428571	2.3950656943686	0.00763156774402533	0.0421962099846734
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	71/4447	229/18639	0.310043668122271	1.29950616823274	0.00784061889604628	0.0431722044608026
GO:0031490	chromatin DNA binding	43/4447	128/18639	0.3359375	1.40803666797841	0.00791829108701082	0.0434197201341461
GO:0140793	histone H2AXY142 phosphatase activity	32/4447	90/18639	0.355555555555556	1.49026309871824	0.00824465362365882	0.0450232730806389
GO:0032183	SUMO binding	9/4447	17/18639	0.529411764705882	2.21895792272385	0.00897972094442451	0.0486371007887809
GO:0051787	misfolded protein binding	9/4447	17/18639	0.529411764705882	2.21895792272385	0.00897972094442451	0.0486371007887809
GO:0001046	core promoter sequence-specific DNA binding	18/4447	44/18639	0.409090909090909	1.71464930392297	0.00902329658656044	0.0486744494730313
GO:0042162	telomeric DNA binding	16/4447	38/18639	0.421052631578947	1.76478524848212	0.00982341796927373	0.0527046437812357
GO:0043024	ribosomal small subunit binding	10/4447	20/18639	0.5	2.09568248257252	0.00984985053334323	0.0527046437812357
GO:0019903	protein phosphatase binding	47/4447	144/18639	0.326388888888889	1.36801495390151	0.0102337945852516	0.0545391382113612
GO:0003950	NAD+ poly-ADP-ribosyltransferase activity	11/4447	23/18639	0.478260869565217	2.00456585289546	0.01034590996929	0.0545410117144779
GO:1990404	NAD+-protein mono-ADP-ribosyltransferase activity	11/4447	23/18639	0.478260869565217	2.00456585289546	0.01034590996929	0.0545410117144779
GO:0030544	Hsp70 protein binding	20/4447	51/18639	0.392156862745098	1.643672535351	0.0104555059042832	0.0545410117144779
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	12/4447	26/18639	0.461538461538462	1.93447613775925	0.010559152715566	0.0545410117144779
GO:0008143	poly(A) binding	12/4447	26/18639	0.461538461538462	1.93447613775925	0.010559152715566	0.0545410117144779
GO:0052742	phosphatidylinositol kinase activity	12/4447	26/18639	0.461538461538462	1.93447613775925	0.010559152715566	0.0545410117144779
GO:0097602	cullin family protein binding	12/4447	26/18639	0.461538461538462	1.93447613775925	0.010559152715566	0.0545410117144779
GO:0106222	lncRNA binding	13/4447	29/18639	0.448275862068966	1.87888774299605	0.010562954039654	0.0545410117144779
GO:0004197	cysteine-type endopeptidase activity	31/4447	88/18639	0.352272727272727	1.476503567267	0.0106674996440141	0.0548398803342235
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0140822	NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0140844	NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0140867	NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	7/4447	12/18639	0.583333333333333	2.44496289633461	0.0109101193731989	0.0548398803342235
GO:0140223	general transcription initiation factor activity	25/4447	68/18639	0.367647058823529	1.54094300189156	0.0115560086711884	0.0577843068495226
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	22/4447	58/18639	0.379310344827586	1.58982809022743	0.0115829884114341	0.0577843068495226
GO:0042809	nuclear vitamin D receptor binding	8/4447	15/18639	0.533333333333333	2.23539464807736	0.0129663761437137	0.0639642421662008
GO:0050700	CARD domain binding	8/4447	15/18639	0.533333333333333	2.23539464807736	0.0129663761437137	0.0639642421662008
GO:0061578	K63-linked deubiquitinase activity	8/4447	15/18639	0.533333333333333	2.23539464807736	0.0129663761437137	0.0639642421662008
GO:0005484	SNAP receptor activity	15/4447	36/18639	0.416666666666667	1.74640206881043	0.0136415936144484	0.0670459063939742
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	80/4447	268/18639	0.298507462686567	1.25115372093882	0.0138111796432987	0.0676289128658943
GO:0051219	phosphoprotein binding	32/4447	93/18639	0.344086021505376	1.44219009553378	0.0138911569304893	0.0677704604660268
GO:0140311	protein sequestering activity	14/4447	33/18639	0.424242424242424	1.7781548336979	0.0141882574631752	0.0689663650316245
GO:0008187	poly-pyrimidine tract binding	13/4447	30/18639	0.433333333333333	1.81625815156285	0.0146407169229754	0.0709059538568917
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	10/4447	21/18639	0.476190476190476	1.9958880786405	0.0148420915646965	0.0713603460375082
GO:0035613	RNA stem-loop binding	10/4447	21/18639	0.476190476190476	1.9958880786405	0.0148420915646965	0.0713603460375082
GO:0008266	poly(U) RNA binding	12/4447	27/18639	0.444444444444444	1.8628288733978	0.0149498124662215	0.0713611551894817
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	12/4447	27/18639	0.444444444444444	1.8628288733978	0.0149498124662215	0.0713611551894817
GO:0035035	histone acetyltransferase binding	11/4447	24/18639	0.458333333333333	1.92104227569148	0.0150479268098677	0.0715720389845676
GO:0005528	FK506 binding	6/4447	10/18639	0.6	2.51481897908702	0.0156183880632389	0.0732353390809825
GO:0008641	ubiquitin-like modifier activating enzyme activity	6/4447	10/18639	0.6	2.51481897908702	0.0156183880632389	0.0732353390809825
GO:0099122	RNA polymerase II C-terminal domain binding	6/4447	10/18639	0.6	2.51481897908702	0.0156183880632389	0.0732353390809825
GO:1905394	retromer complex binding	6/4447	10/18639	0.6	2.51481897908702	0.0156183880632389	0.0732353390809825
GO:0048156	tau protein binding	17/4447	43/18639	0.395348837209302	1.6570512652899	0.0160410174700989	0.0749522189535958
GO:0016860	intramolecular oxidoreductase activity	20/4447	53/18639	0.377358490566038	1.58164715665851	0.0166186825857669	0.0773789185660096
GO:0032451	demethylase activity	16/4447	40/18639	0.4	1.67654598605802	0.0170138893617224	0.0781225992491542
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	16/4447	40/18639	0.4	1.67654598605802	0.0170138893617224	0.0781225992491542
GO:0061791	GTPase motor activity	16/4447	40/18639	0.4	1.67654598605802	0.0170138893617224	0.0781225992491542
GO:1990606	membrane scission GTPase motor activity	16/4447	40/18639	0.4	1.67654598605802	0.0170138893617224	0.0781225992491542
GO:0001217	DNA-binding transcription repressor activity	82/4447	278/18639	0.294964028776978	1.23630189619386	0.0173122490053111	0.0792184635518891
GO:0042054	histone methyltransferase activity	24/4447	67/18639	0.358208955223881	1.50138446512658	0.0184751291852547	0.084066901763879
GO:0046974	histone H3K9 methyltransferase activity	7/4447	13/18639	0.538461538461538	2.25688882738579	0.0188208477490022	0.084066901763879
GO:0046975	histone H3K36 methyltransferase activity	7/4447	13/18639	0.538461538461538	2.25688882738579	0.0188208477490022	0.084066901763879
GO:0097157	pre-mRNA intronic binding	7/4447	13/18639	0.538461538461538	2.25688882738579	0.0188208477490022	0.084066901763879
GO:0140806	NAD+-protein-aspartate ADP-ribosyltransferase activity	7/4447	13/18639	0.538461538461538	2.25688882738579	0.0188208477490022	0.084066901763879
GO:0042826	histone deacetylase binding	41/4447	127/18639	0.322834645669291	1.35311782339328	0.0188808989969222	0.084066901763879
GO:0008175	tRNA methyltransferase activity	14/4447	34/18639	0.411764705882353	1.72585616211855	0.0189316628844404	0.084066901763879
GO:0052866	phosphatidylinositol phosphate phosphatase activity	14/4447	34/18639	0.411764705882353	1.72585616211855	0.0189316628844404	0.084066901763879
GO:0003678	DNA helicase activity	26/4447	74/18639	0.351351351351351	1.47264174451042	0.0189419771118311	0.084066901763879
GO:0003954	NADH dehydrogenase activity	17/4447	44/18639	0.386363636363636	1.61939100926058	0.0204595824708453	0.0887259975824616
GO:0016790	thiolester hydrolase activity	17/4447	44/18639	0.386363636363636	1.61939100926058	0.0204595824708453	0.0887259975824616
GO:0004708	MAP kinase kinase activity	8/4447	16/18639	0.5	2.09568248257252	0.0205849990042946	0.0887259975824616
GO:0005159	insulin-like growth factor receptor binding	8/4447	16/18639	0.5	2.09568248257252	0.0205849990042946	0.0887259975824616
GO:0005521	lamin binding	8/4447	16/18639	0.5	2.09568248257252	0.0205849990042946	0.0887259975824616
GO:0070411	I-SMAD binding	8/4447	16/18639	0.5	2.09568248257252	0.0205849990042946	0.0887259975824616
GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	8/4447	16/18639	0.5	2.09568248257252	0.0205849990042946	0.0887259975824616
GO:0019789	SUMO transferase activity	12/4447	28/18639	0.428571428571429	1.79629927077645	0.0205935246837967	0.0887259975824616
GO:0046875	ephrin receptor binding	12/4447	28/18639	0.428571428571429	1.79629927077645	0.0205935246837967	0.0887259975824616
GO:0008139	nuclear localization sequence binding	11/4447	25/18639	0.44	1.84420058466382	0.0211876663547095	0.0906968814603211
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	11/4447	25/18639	0.44	1.84420058466382	0.0211876663547095	0.0906968814603211
GO:0003756	protein disulfide isomerase activity	9/4447	19/18639	0.473684210526316	1.98538340454239	0.0213691823651417	0.0908465422223673
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	9/4447	19/18639	0.473684210526316	1.98538340454239	0.0213691823651417	0.0908465422223673
GO:0050321	tau-protein kinase activity	10/4447	22/18639	0.454545454545455	1.90516589324775	0.021496468920741	0.0908465422223673
GO:0140035	ubiquitin-like protein reader activity	10/4447	22/18639	0.454545454545455	1.90516589324775	0.021496468920741	0.0908465422223673
GO:0005548	phospholipid transporter activity	24/4447	68/18639	0.352941176470588	1.4793052818159	0.0222491949201999	0.0937291481241438
GO:0032266	phosphatidylinositol-3-phosphate binding	18/4447	48/18639	0.375	1.57176186192939	0.0239248515923306	0.100469234376654
GO:0005154	epidermal growth factor receptor binding	14/4447	35/18639	0.4	1.67654598605802	0.0247816018804243	0.103738756136666
GO:0140313	molecular sequestering activity	20/4447	55/18639	0.363636363636364	1.5241327145982	0.0253044549459137	0.10559437645669
GO:0140303	intramembrane lipid transporter activity	17/4447	45/18639	0.377777777777778	1.58340454238813	0.0257488592010823	0.107112025579424
GO:0019209	kinase activator activity	46/4447	148/18639	0.310810810810811	1.30272154322076	0.0266914465953709	0.110460043498046
GO:0051536	iron-sulfur cluster binding	26/4447	76/18639	0.342105263157895	1.43388801439172	0.0267201763096254	0.110460043498046
GO:0019107	myristoyltransferase activity	6/4447	11/18639	0.545454545454545	2.2861990718973	0.0275002046531008	0.113331588741195
GO:0016410	N-acyltransferase activity	31/4447	94/18639	0.329787234042553	1.38225865871805	0.0280967390006173	0.11543149428427
GO:0031593	polyubiquitin modification-dependent protein binding	21/4447	59/18639	0.355932203389831	1.49184176725501	0.0283637558357823	0.116168839487911
GO:0050681	nuclear androgen receptor binding	11/4447	26/18639	0.423076923076923	1.77326979294598	0.0289819096900814	0.118335366642271
GO:0032454	histone H3K9 demethylase activity	7/4447	14/18639	0.5	2.09568248257252	0.0300101277539792	0.122157789967884
GO:0030742	GTP-dependent protein binding	9/4447	20/18639	0.45	1.88611423431527	0.0307940902275223	0.124636364401173
GO:0016805	dipeptidase activity	8/4447	17/18639	0.470588235294118	1.9724070424212	0.0309008017241792	0.124636364401173
GO:0032977	membrane insertase activity	8/4447	17/18639	0.470588235294118	1.9724070424212	0.0309008017241792	0.124636364401173
GO:0051540	metal cluster binding	26/4447	77/18639	0.337662337662338	1.4152660921269	0.0314296192961861	0.126385166078906
GO:0055106	ubiquitin-protein transferase regulator activity	14/4447	36/18639	0.388888888888889	1.62997526422307	0.0318706980496816	0.127771650489207
GO:0016251	RNA polymerase II general transcription initiation factor activity	19/4447	53/18639	0.358490566037736	1.50256479882558	0.0333780948816562	0.133411843096258
GO:0042578	phosphoric ester hydrolase activity	102/4447	363/18639	0.28099173553719	1.17773891582588	0.0336863880787773	0.134239750692305
GO:0098531	ligand-modulated transcription factor activity	21/4447	60/18639	0.35	1.46697773780076	0.0340932565293832	0.13545434555237
GO:0008173	RNA methyltransferase activity	23/4447	67/18639	0.343283582089552	1.43882677907964	0.034318698088827	0.135943021981712
GO:1901981	phosphatidylinositol phosphate binding	55/4447	185/18639	0.297297297297297	1.2460814761242	0.0385810720898575	0.152372269831074
GO:0140938	histone H3 methyltransferase activity	17/4447	47/18639	0.361702127659574	1.51602562569076	0.0393033409192322	0.154764194064751
GO:0051213	dioxygenase activity	30/4447	93/18639	0.32258064516129	1.35205321456292	0.0404871482116296	0.158953981292404
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	21/4447	61/18639	0.344262295081967	1.44292892242698	0.0406401339164762	0.159083946038832
GO:0140612	DNA damage sensor activity	10/4447	24/18639	0.416666666666667	1.74640206881043	0.040806604210641	0.159265775845649
GO:0001223	transcription coactivator binding	16/4447	44/18639	0.363636363636364	1.5241327145982	0.0426564005251801	0.165422695046938
GO:0043014	alpha-tubulin binding	16/4447	44/18639	0.363636363636364	1.5241327145982	0.0426564005251801	0.165422695046938
GO:0072542	protein phosphatase activator activity	9/4447	21/18639	0.428571428571429	1.79629927077645	0.0427580892246418	0.165422695046938
GO:0000995	RNA polymerase III general transcription initiation factor activity	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0004300	enoyl-CoA hydratase activity	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0005527	macrolide binding	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0016423	tRNA (guanine) methyltransferase activity	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0016801	hydrolase activity, acting on ether bonds	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0016803	ether hydrolase activity	6/4447	12/18639	0.5	2.09568248257252	0.0440902899330027	0.166845121338215
GO:0008409	5'-3' exonuclease activity	8/4447	18/18639	0.444444444444444	1.8628288733978	0.0442573343715537	0.166845121338215
GO:0017128	phospholipid scramblase activity	8/4447	18/18639	0.444444444444444	1.8628288733978	0.0442573343715537	0.166845121338215
GO:1990381	ubiquitin-specific protease binding	8/4447	18/18639	0.444444444444444	1.8628288733978	0.0442573343715537	0.166845121338215
GO:0031386	protein tag activity	7/4447	15/18639	0.466666666666667	1.95597031706769	0.0449234104129614	0.16792497357183
GO:0140776	protein-containing complex destabilizing activity	7/4447	15/18639	0.466666666666667	1.95597031706769	0.0449234104129614	0.16792497357183
GO:0141047	molecular tag activity	7/4447	15/18639	0.466666666666667	1.95597031706769	0.0449234104129614	0.16792497357183
GO:0008137	NADH dehydrogenase (ubiquinone) activity	15/4447	41/18639	0.365853658536585	1.53342620676038	0.0462974554408148	0.172575065645958
GO:0009055	electron transfer activity	36/4447	116/18639	0.310344827586207	1.30076843745881	0.0465819955017308	0.173149322215117
GO:0043531	ADP binding	14/4447	38/18639	0.368421052631579	1.54418709242186	0.0502473754806392	0.186252143192202
GO:0030295	protein kinase activator activity	42/4447	139/18639	0.302158273381295	1.26645560097908	0.0506109940633192	0.186656898250653
GO:0008017	microtubule binding	78/4447	276/18639	0.282608695652174	1.18451618580186	0.0506378925171327	0.186656898250653
GO:0004879	nuclear receptor activity	20/4447	59/18639	0.338983050847458	1.42080168310001	0.0524103162349479	0.192655095966138
GO:0043015	gamma-tubulin binding	13/4447	35/18639	0.371428571428571	1.55679270133959	0.0545257482793561	0.199877535819629
GO:0004713	protein tyrosine kinase activity	42/4447	140/18639	0.3	1.25740948954351	0.0561223821409875	0.205163639396943
GO:0005543	phospholipid binding	134/4447	497/18639	0.269617706237425	1.13006620790631	0.0571245910666158	0.207827987529612
GO:0004407	histone deacetylase activity	9/4447	22/18639	0.409090909090909	1.71464930392297	0.0574776725119575	0.207827987529612
GO:0033558	protein lysine deacetylase activity	9/4447	22/18639	0.409090909090909	1.71464930392297	0.0574776725119575	0.207827987529612
GO:0070034	telomerase RNA binding	9/4447	22/18639	0.409090909090909	1.71464930392297	0.0574776725119575	0.207827987529612
GO:0003684	damaged DNA binding	24/4447	74/18639	0.324324324324324	1.35936161031731	0.0585471195063735	0.211119640176515
GO:0140142	nucleocytoplasmic carrier activity	12/4447	32/18639	0.375	1.57176186192939	0.059148747448005	0.212711078220874
GO:0019888	protein phosphatase regulator activity	33/4447	107/18639	0.308411214953271	1.29266396121296	0.0593142972913661	0.212729925690927
GO:0019902	phosphatase binding	55/4447	190/18639	0.289473684210526	1.21328985833146	0.0605973049771059	0.216671930665766
GO:0097001	ceramide binding	8/4447	19/18639	0.421052631578947	1.76478524848212	0.0609032631034897	0.216671930665766
GO:0140036	ubiquitin-modified protein reader activity	8/4447	19/18639	0.421052631578947	1.76478524848212	0.0609032631034897	0.216671930665766
GO:0017124	SH3 domain binding	35/4447	115/18639	0.304347826086957	1.27563281547893	0.06333830005173	0.224732417563224
GO:0031435	mitogen-activated protein kinase kinase kinase binding	7/4447	16/18639	0.4375	1.83372217225096	0.0638532859530356	0.22511744960205
GO:0043023	ribosomal large subunit binding	7/4447	16/18639	0.4375	1.83372217225096	0.0638532859530356	0.22511744960205
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	11/4447	29/18639	0.379310344827586	1.58982809022743	0.0641253925769215	0.22511744960205
GO:0097472	cyclin-dependent protein kinase activity	11/4447	29/18639	0.379310344827586	1.58982809022743	0.0641253925769215	0.22511744960205
GO:0008140	cAMP response element binding protein binding	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0015924	mannosyl-oligosaccharide mannosidase activity	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0016783	sulfurtransferase activity	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0043422	protein kinase B binding	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0051864	histone H3K36 demethylase activity	5/4447	10/18639	0.5	2.09568248257252	0.065448726030942	0.225452197067801
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	6/4447	13/18639	0.461538461538462	1.93447613775925	0.0657498118050031	0.225452197067801
GO:0035673	oligopeptide transmembrane transporter activity	6/4447	13/18639	0.461538461538462	1.93447613775925	0.0657498118050031	0.225452197067801
GO:0140838	RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity	13/4447	36/18639	0.361111111111111	1.51354845963571	0.0673307766700416	0.229097283695244
GO:0140839	RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	13/4447	36/18639	0.361111111111111	1.51354845963571	0.0673307766700416	0.229097283695244
GO:0140840	RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	13/4447	36/18639	0.361111111111111	1.51354845963571	0.0673307766700416	0.229097283695244
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	22/4447	68/18639	0.323529411764706	1.35602984166457	0.0696421410020232	0.235752859973686
GO:1990841	promoter-specific chromatin binding	22/4447	68/18639	0.323529411764706	1.35602984166457	0.0696421410020232	0.235752859973686
GO:0016836	hydro-lyase activity	20/4447	61/18639	0.327868852459016	1.37421802135903	0.0717779739761463	0.242364812891466
GO:0071889	14-3-3 protein binding	12/4447	33/18639	0.363636363636364	1.5241327145982	0.0734665528896795	0.247048819663248
GO:0051287	NAD binding	18/4447	54/18639	0.333333333333333	1.39712165504835	0.0735375160263624	0.247048819663248
GO:0030331	nuclear estrogen receptor binding	14/4447	40/18639	0.35	1.46697773780076	0.0748657352123596	0.250875834916164
GO:0005158	insulin receptor binding	9/4447	23/18639	0.391304347826087	1.64009933418719	0.0750944335808682	0.251008345999527
GO:0160215	deacylase activity	21/4447	65/18639	0.323076923076923	1.35413329643148	0.0760323520528804	0.253504852196413
GO:0017116	single-stranded DNA helicase activity	19/4447	58/18639	0.327586206896552	1.37303335065096	0.0784641622785674	0.260304858359147
GO:0061980	regulatory RNA binding	19/4447	58/18639	0.327586206896552	1.37303335065096	0.0784641622785674	0.260304858359147
GO:0035925	mRNA 3'-UTR AU-rich region binding	11/4447	30/18639	0.366666666666667	1.53683382055318	0.0801985103894723	0.264668009218235
GO:0005048	signal sequence binding	17/4447	51/18639	0.333333333333333	1.39712165504835	0.0804776968903695	0.264668009218235
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	129/4447	484/18639	0.266528925619835	1.11712000104072	0.0808627876903223	0.264668009218235
GO:0000339	RNA cap binding	8/4447	20/18639	0.4	1.67654598605802	0.0809760450208013	0.264668009218235
GO:0052745	inositol phosphate phosphatase activity	8/4447	20/18639	0.4	1.67654598605802	0.0809760450208013	0.264668009218235
GO:0140664	ATP-dependent DNA damage sensor activity	8/4447	20/18639	0.4	1.67654598605802	0.0809760450208013	0.264668009218235
GO:0051117	ATPase binding	26/4447	84/18639	0.30952380952381	1.29732725111632	0.083360557600303	0.271792284854059
GO:0016651	oxidoreductase activity, acting on NAD(P)H	27/4447	88/18639	0.306818181818182	1.28598697794223	0.0863462373024923	0.280639593819618
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	7/4447	17/18639	0.411764705882353	1.72585616211855	0.086920024913235	0.280639593819618
GO:0046965	nuclear retinoid X receptor binding	7/4447	17/18639	0.411764705882353	1.72585616211855	0.086920024913235	0.280639593819618
GO:0070403	NAD+ binding	7/4447	17/18639	0.411764705882353	1.72585616211855	0.086920024913235	0.280639593819618
GO:0043138	3'-5' DNA helicase activity	16/4447	48/18639	0.333333333333333	1.39712165504835	0.0881648994632362	0.283280439679696
GO:0140693	molecular condensate scaffold activity	16/4447	48/18639	0.333333333333333	1.39712165504835	0.0881648994632362	0.283280439679696
GO:0001727	lipid kinase activity	14/4447	41/18639	0.341463414634146	1.43119779297636	0.0896789173161236	0.287449090044676
GO:0005545	1-phosphatidylinositol binding	6/4447	14/18639	0.428571428571429	1.79629927077645	0.0925545748432711	0.293827561763207
GO:0061665	SUMO ligase activity	6/4447	14/18639	0.428571428571429	1.79629927077645	0.0925545748432711	0.293827561763207
GO:0070742	C2H2 zinc finger domain binding	6/4447	14/18639	0.428571428571429	1.79629927077645	0.0925545748432711	0.293827561763207
GO:0071933	Arp2/3 complex binding	6/4447	14/18639	0.428571428571429	1.79629927077645	0.0925545748432711	0.293827561763207
GO:0001216	DNA-binding transcription activator activity	130/4447	491/18639	0.264765784114053	1.1097300315048	0.0935031382046764	0.295440312197898
GO:0035401	histone H3Y41 kinase activity	34/4447	115/18639	0.295652173913043	1.2391861636081	0.0937304984440956	0.295440312197898
GO:0140801	histone H2AXY142 kinase activity	34/4447	115/18639	0.295652173913043	1.2391861636081	0.0937304984440956	0.295440312197898
GO:0001091	RNA polymerase II general transcription initiation factor binding	9/4447	24/18639	0.375	1.57176186192939	0.0956671312030044	0.299411045062233
GO:0048027	mRNA 5'-UTR binding	9/4447	24/18639	0.375	1.57176186192939	0.0956671312030044	0.299411045062233
GO:0140033	acetylation-dependent protein binding	9/4447	24/18639	0.375	1.57176186192939	0.0956671312030044	0.299411045062233
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	5/4447	11/18639	0.454545454545455	1.90516589324775	0.0970724938458096	0.300970091900442
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5/4447	11/18639	0.454545454545455	1.90516589324775	0.0970724938458096	0.300970091900442
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	5/4447	11/18639	0.454545454545455	1.90516589324775	0.0970724938458096	0.300970091900442
GO:0140031	phosphorylation-dependent protein binding	5/4447	11/18639	0.454545454545455	1.90516589324775	0.0970724938458096	0.300970091900442
GO:0005123	death receptor binding	8/4447	21/18639	0.380952380952381	1.5967104629124	0.104494787049207	0.320982829662726
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	8/4447	21/18639	0.380952380952381	1.5967104629124	0.104494787049207	0.320982829662726
GO:0051010	microtubule plus-end binding	8/4447	21/18639	0.380952380952381	1.5967104629124	0.104494787049207	0.320982829662726
GO:0140312	cargo adaptor activity	8/4447	21/18639	0.380952380952381	1.5967104629124	0.104494787049207	0.320982829662726
GO:0004520	DNA endonuclease activity	14/4447	42/18639	0.333333333333333	1.39712165504835	0.106199468113622	0.323969411923623
GO:0016859	cis-trans isomerase activity	14/4447	42/18639	0.333333333333333	1.39712165504835	0.106199468113622	0.323969411923623
GO:0035198	miRNA binding	14/4447	42/18639	0.333333333333333	1.39712165504835	0.106199468113622	0.323969411923623
GO:0034061	DNA polymerase activity	12/4447	35/18639	0.342857142857143	1.43703941662116	0.108240460383147	0.327348516674857
GO:0045499	chemorepellent activity	10/4447	28/18639	0.357142857142857	1.49691605898037	0.108293895117002	0.327348516674857
GO:0046625	sphingolipid binding	10/4447	28/18639	0.357142857142857	1.49691605898037	0.108293895117002	0.327348516674857
GO:0051019	mitogen-activated protein kinase binding	10/4447	28/18639	0.357142857142857	1.49691605898037	0.108293895117002	0.327348516674857
GO:0004536	DNA nuclease activity	20/4447	64/18639	0.3125	1.30980155160783	0.109003880355104	0.328745793707325
GO:0016835	carbon-oxygen lyase activity	24/4447	79/18639	0.30379746835443	1.27332606536052	0.111042501900169	0.33413469392636
GO:0000400	four-way junction DNA binding	7/4447	18/18639	0.388888888888889	1.62997526422307	0.114069009803396	0.339232790532024
GO:0004706	JUN kinase kinase kinase activity	7/4447	18/18639	0.388888888888889	1.62997526422307	0.114069009803396	0.339232790532024
GO:0070064	proline-rich region binding	7/4447	18/18639	0.388888888888889	1.62997526422307	0.114069009803396	0.339232790532024
GO:0070628	proteasome binding	7/4447	18/18639	0.388888888888889	1.62997526422307	0.114069009803396	0.339232790532024
GO:0098641	cadherin binding involved in cell-cell adhesion	7/4447	18/18639	0.388888888888889	1.62997526422307	0.114069009803396	0.339232790532024
GO:0016504	peptidase activator activity	18/4447	57/18639	0.315789473684211	1.32358893636159	0.114270578272656	0.339232790532024
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	13/4447	39/18639	0.333333333333333	1.39712165504835	0.116807436253144	0.345219304917421
GO:0016776	phosphotransferase activity, phosphate group as acceptor	13/4447	39/18639	0.333333333333333	1.39712165504835	0.116807436253144	0.345219304917421
GO:0000030	mannosyltransferase activity	9/4447	25/18639	0.36	1.50889138745221	0.119169075940235	0.348426419071109
GO:0004709	MAP kinase kinase kinase activity	9/4447	25/18639	0.36	1.50889138745221	0.119169075940235	0.348426419071109
GO:0017056	structural constituent of nuclear pore	9/4447	25/18639	0.36	1.50889138745221	0.119169075940235	0.348426419071109
GO:0042974	nuclear retinoic acid receptor binding	9/4447	25/18639	0.36	1.50889138745221	0.119169075940235	0.348426419071109
GO:0031369	translation initiation factor binding	11/4447	32/18639	0.34375	1.44078170676861	0.119205421445579	0.348426419071109
GO:0019843	rRNA binding	20/4447	65/18639	0.307692307692308	1.28965075850617	0.12365789293387	0.358603531050075
GO:0004559	alpha-mannosidase activity	6/4447	15/18639	0.4	1.67654598605802	0.124308684463478	0.358603531050075
GO:0008252	nucleotidase activity	6/4447	15/18639	0.4	1.67654598605802	0.124308684463478	0.358603531050075
GO:0055105	ubiquitin-protein transferase inhibitor activity	6/4447	15/18639	0.4	1.67654598605802	0.124308684463478	0.358603531050075
GO:0141050	histone H3K deacetylase activity	6/4447	15/18639	0.4	1.67654598605802	0.124308684463478	0.358603531050075
GO:0141051	histone H4K deacetylase activity	6/4447	15/18639	0.4	1.67654598605802	0.124308684463478	0.358603531050075
GO:1990518	single-stranded 3'-5' DNA helicase activity	15/4447	47/18639	0.319148936170213	1.33766966972714	0.131220195714605	0.375683165290581
GO:0008093	cytoskeletal anchor activity	8/4447	22/18639	0.363636363636364	1.5241327145982	0.131361709641921	0.375683165290581
GO:0034062	5'-3' RNA polymerase activity	8/4447	22/18639	0.363636363636364	1.5241327145982	0.131361709641921	0.375683165290581
GO:0097747	RNA polymerase activity	8/4447	22/18639	0.363636363636364	1.5241327145982	0.131361709641921	0.375683165290581
GO:0000340	RNA 7-methylguanosine cap binding	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:0005049	nuclear export signal receptor activity	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:0035497	cAMP response element binding	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:0141221	histone deacetylase activity, hydrolytic mechanism	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:1990459	transferrin receptor binding	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:1990817	poly(A) RNA polymerase activity	5/4447	12/18639	0.416666666666667	1.74640206881043	0.1349169252121	0.380116262752563
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	13/4447	40/18639	0.325	1.36219361367214	0.137001588606114	0.385171839153206
GO:0004519	endonuclease activity	36/4447	127/18639	0.283464566929134	1.18810345468678	0.139231102478501	0.390612416467168
GO:0019205	nucleobase-containing compound kinase activity	14/4447	44/18639	0.318181818181818	1.33361612527342	0.144315492471802	0.402220527834054
GO:0046527	glucosyltransferase activity	7/4447	19/18639	0.368421052631579	1.54418709242186	0.145082362045008	0.402220527834054
GO:0005160	transforming growth factor beta receptor binding	9/4447	26/18639	0.346153846153846	1.45085710331944	0.145490469751579	0.402220527834054
GO:0030507	spectrin binding	9/4447	26/18639	0.346153846153846	1.45085710331944	0.145490469751579	0.402220527834054
GO:0034237	protein kinase A regulatory subunit binding	9/4447	26/18639	0.346153846153846	1.45085710331944	0.145490469751579	0.402220527834054
GO:0050750	low-density lipoprotein particle receptor binding	9/4447	26/18639	0.346153846153846	1.45085710331944	0.145490469751579	0.402220527834054
GO:0070412	R-SMAD binding	9/4447	26/18639	0.346153846153846	1.45085710331944	0.145490469751579	0.402220527834054
GO:0036002	pre-mRNA binding	18/4447	59/18639	0.305084745762712	1.27872151479001	0.147744125805917	0.40675613059015
GO:0045309	protein phosphorylated amino acid binding	18/4447	59/18639	0.305084745762712	1.27872151479001	0.147744125805917	0.40675613059015
GO:0009378	four-way junction helicase activity	15/4447	48/18639	0.3125	1.30980155160783	0.150790784919773	0.414284413226789
GO:0070566	adenylyltransferase activity	10/4447	30/18639	0.333333333333333	1.39712165504835	0.157211457907147	0.42999842477732
GO:0016877	ligase activity, forming carbon-sulfur bonds	13/4447	41/18639	0.317073170731707	1.32896937919233	0.158972828847895	0.42999842477732
GO:0140318	protein transporter activity	13/4447	41/18639	0.317073170731707	1.32896937919233	0.158972828847895	0.42999842477732
GO:0003688	DNA replication origin binding	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0004707	MAP kinase activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0015923	mannosidase activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0017070	U6 snRNA binding	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0034450	ubiquitin-ubiquitin ligase activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0097027	ubiquitin-protein transferase activator activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0140327	flippase activity	6/4447	16/18639	0.375	1.57176186192939	0.160581923569743	0.42999842477732
GO:0003887	DNA-directed DNA polymerase activity	8/4447	23/18639	0.347826086956522	1.45786607483306	0.16137092354115	0.42999842477732
GO:0042171	lysophosphatidic acid acyltransferase activity	8/4447	23/18639	0.347826086956522	1.45786607483306	0.16137092354115	0.42999842477732
GO:0070577	lysine-acetylated histone binding	8/4447	23/18639	0.347826086956522	1.45786607483306	0.16137092354115	0.42999842477732
GO:0071617	lysophospholipid acyltransferase activity	8/4447	23/18639	0.347826086956522	1.45786607483306	0.16137092354115	0.42999842477732
GO:0032934	sterol binding	20/4447	68/18639	0.294117647058824	1.23275440151325	0.174230251633107	0.462977011003422
GO:0140326	ATPase-coupled intramembrane lipid transporter activity	9/4447	27/18639	0.333333333333333	1.39712165504835	0.174444992842284	0.462977011003422
GO:0051018	protein kinase A binding	16/4447	53/18639	0.30188679245283	1.26531772532681	0.177144282850395	0.466400633219372
GO:0005338	nucleotide-sugar transmembrane transporter activity	5/4447	13/18639	0.384615384615385	1.61206344813271	0.178146371091536	0.466400633219372
GO:0008253	5'-nucleotidase activity	5/4447	13/18639	0.384615384615385	1.61206344813271	0.178146371091536	0.466400633219372
GO:0009982	pseudouridine synthase activity	5/4447	13/18639	0.384615384615385	1.61206344813271	0.178146371091536	0.466400633219372
GO:0019855	calcium channel inhibitor activity	5/4447	13/18639	0.384615384615385	1.61206344813271	0.178146371091536	0.466400633219372
GO:0051011	microtubule minus-end binding	5/4447	13/18639	0.384615384615385	1.61206344813271	0.178146371091536	0.466400633219372
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	7/4447	20/18639	0.35	1.46697773780076	0.179601148134966	0.466400633219372
GO:0015095	magnesium ion transmembrane transporter activity	7/4447	20/18639	0.35	1.46697773780076	0.179601148134966	0.466400633219372
GO:0016408	C-acyltransferase activity	7/4447	20/18639	0.35	1.46697773780076	0.179601148134966	0.466400633219372
GO:0016505	peptidase activator activity involved in apoptotic process	7/4447	20/18639	0.35	1.46697773780076	0.179601148134966	0.466400633219372
GO:0061608	nuclear import signal receptor activity	7/4447	20/18639	0.35	1.46697773780076	0.179601148134966	0.466400633219372
GO:0070325	lipoprotein particle receptor binding	10/4447	31/18639	0.32258064516129	1.35205321456292	0.185140276072973	0.479845988962568
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	14/4447	46/18639	0.304347826086957	1.27563281547893	0.188850161582693	0.486610028000453
GO:0030276	clathrin binding	14/4447	46/18639	0.304347826086957	1.27563281547893	0.188850161582693	0.486610028000453
GO:0030291	protein serine/threonine kinase inhibitor activity	14/4447	46/18639	0.304347826086957	1.27563281547893	0.188850161582693	0.486610028000453
GO:0120013	lipid transfer activity	19/4447	65/18639	0.292307692307692	1.22516822058086	0.189813830136195	0.488145256958781
GO:0004622	lysophospholipase activity	8/4447	24/18639	0.333333333333333	1.39712165504835	0.194222819710222	0.496596689316888
GO:0030215	semaphorin receptor binding	8/4447	24/18639	0.333333333333333	1.39712165504835	0.194222819710222	0.496596689316888
GO:0050431	transforming growth factor beta binding	8/4447	24/18639	0.333333333333333	1.39712165504835	0.194222819710222	0.496596689316888
GO:0005381	iron ion transmembrane transporter activity	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0030957	Tat protein binding	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0031996	thioesterase binding	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0033204	ribonuclease P RNA binding	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0097177	mitochondrial ribosome binding	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:1990757	ubiquitin ligase activator activity	4/4447	10/18639	0.4	1.67654598605802	0.198043632765844	0.498679128425569
GO:0015485	cholesterol binding	16/4447	54/18639	0.296296296296296	1.24188591559853	0.199018091457049	0.499831208502583
GO:0031489	myosin V binding	6/4447	17/18639	0.352941176470588	1.4793052818159	0.200761141018747	0.499831208502583
GO:0038191	neuropilin binding	6/4447	17/18639	0.352941176470588	1.4793052818159	0.200761141018747	0.499831208502583
GO:0048038	quinone binding	6/4447	17/18639	0.352941176470588	1.4793052818159	0.200761141018747	0.499831208502583
GO:0070402	NADPH binding	6/4447	17/18639	0.352941176470588	1.4793052818159	0.200761141018747	0.499831208502583
GO:1990226	histone methyltransferase binding	6/4447	17/18639	0.352941176470588	1.4793052818159	0.200761141018747	0.499831208502583
GO:0044325	transmembrane transporter binding	37/4447	136/18639	0.272058823529412	1.14029782139975	0.204957147227256	0.509322349008557
GO:0097110	scaffold protein binding	20/4447	70/18639	0.285714285714286	1.1975328471843	0.213104771793812	0.527091413112409
GO:0001784	phosphotyrosine residue binding	14/4447	47/18639	0.297872340425532	1.24849169174533	0.213299238011578	0.527091413112409
GO:0061749	forked DNA-dependent helicase activity	14/4447	47/18639	0.297872340425532	1.24849169174533	0.213299238011578	0.527091413112409
GO:0120015	sterol transfer activity	10/4447	32/18639	0.3125	1.30980155160783	0.21511066453997	0.530579650268661
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7/4447	21/18639	0.333333333333333	1.39712165504835	0.217154328677845	0.532650266461183
GO:0009931	calcium-dependent protein serine/threonine kinase activity	7/4447	21/18639	0.333333333333333	1.39712165504835	0.217154328677845	0.532650266461183
GO:0010314	phosphatidylinositol-5-phosphate binding	7/4447	21/18639	0.333333333333333	1.39712165504835	0.217154328677845	0.532650266461183
GO:0016209	antioxidant activity	24/4447	86/18639	0.27906976744186	1.16968324608699	0.222009530648865	0.543554699577572
GO:0004705	JUN kinase activity	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0005347	ATP transmembrane transporter activity	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0019992	diacylglycerol binding	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0034236	protein kinase A catalytic subunit binding	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0046030	inositol trisphosphate phosphatase activity	5/4447	14/18639	0.357142857142857	1.49691605898037	0.225697369007239	0.546533592468259
GO:0047617	fatty acyl-CoA hydrolase activity	8/4447	25/18639	0.32	1.34123678884641	0.229542228543157	0.554831579739107
GO:0005319	lipid transporter activity	47/4447	178/18639	0.264044943820225	1.10670872675178	0.235831326305453	0.568996672740612
GO:0036121	double-stranded DNA helicase activity	14/4447	48/18639	0.291666666666667	1.2224814481673	0.239038012814086	0.575003006858669
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	9/4447	29/18639	0.310344827586207	1.30076843745881	0.239187384917849	0.575003006858669
GO:0005080	protein kinase C binding	15/4447	52/18639	0.288461538461538	1.20904758609953	0.242912840241771	0.581850792420271
GO:0030159	signaling receptor complex adaptor activity	15/4447	52/18639	0.288461538461538	1.20904758609953	0.242912840241771	0.581850792420271
GO:0035615	clathrin adaptor activity	6/4447	18/18639	0.333333333333333	1.39712165504835	0.244107206626422	0.583658131879751
GO:0019213	deacetylase activity	11/4447	37/18639	0.297297297297297	1.2460814761242	0.25308088074334	0.598534167334206
GO:0005225	volume-sensitive anion channel activity	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0008432	JUN kinase binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0019215	intermediate filament binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0032129	histone H3K9 deacetylase activity, hydrolytic mechanism	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0034056	estrogen response element binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0034713	type I transforming growth factor beta receptor binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0048185	activin binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0140937	histone H4K12 deacetylase activity, hydrolytic mechanism	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0180030	inositol phosphate kinase activity	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:1900750	oligopeptide binding	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:1990948	ubiquitin ligase inhibitor activity	4/4447	11/18639	0.363636363636364	1.5241327145982	0.255741426434435	0.598534167334206
GO:0008649	rRNA methyltransferase activity	7/4447	22/18639	0.318181818181818	1.33361612527342	0.257190884227942	0.600866731286056
GO:0004715	non-membrane spanning protein tyrosine kinase activity	13/4447	45/18639	0.288888888888889	1.21083876770857	0.262398412133745	0.610881917371017
GO:0051539	4 iron, 4 sulfur cluster binding	13/4447	45/18639	0.288888888888889	1.21083876770857	0.262398412133745	0.610881917371017
GO:0004529	DNA exonuclease activity	8/4447	26/18639	0.307692307692308	1.28965075850617	0.266898565783859	0.615955472687271
GO:0008198	ferrous iron binding	8/4447	26/18639	0.307692307692308	1.28965075850617	0.266898565783859	0.615955472687271
GO:0016289	acyl-CoA hydrolase activity	8/4447	26/18639	0.307692307692308	1.28965075850617	0.266898565783859	0.615955472687271
GO:0051139	metal cation:proton antiporter activity	8/4447	26/18639	0.307692307692308	1.28965075850617	0.266898565783859	0.615955472687271
GO:0070006	metalloaminopeptidase activity	8/4447	26/18639	0.307692307692308	1.28965075850617	0.266898565783859	0.615955472687271
GO:0019905	syntaxin binding	17/4447	61/18639	0.278688524590164	1.16808531815518	0.273460458758838	0.629796782978621
GO:0015215	nucleotide transmembrane transporter activity	9/4447	30/18639	0.3	1.25740948954351	0.274319925065292	0.629796782978621
GO:0051721	protein phosphatase 2A binding	9/4447	30/18639	0.3	1.25740948954351	0.274319925065292	0.629796782978621
GO:0004698	calcium,diacylglycerol-dependent serine/threonine kinase activity	5/4447	15/18639	0.333333333333333	1.39712165504835	0.276391711279119	0.630192097710294
GO:0004699	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	5/4447	15/18639	0.333333333333333	1.39712165504835	0.276391711279119	0.630192097710294
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	5/4447	15/18639	0.333333333333333	1.39712165504835	0.276391711279119	0.630192097710294
GO:0120283	protein serine/threonine kinase binding	5/4447	15/18639	0.333333333333333	1.39712165504835	0.276391711279119	0.630192097710294
GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	6/4447	19/18639	0.315789473684211	1.32358893636159	0.289810981048613	0.655160429048568
GO:0005346	purine ribonucleotide transmembrane transporter activity	6/4447	19/18639	0.315789473684211	1.32358893636159	0.289810981048613	0.655160429048568
GO:0008301	DNA binding, bending	6/4447	19/18639	0.315789473684211	1.32358893636159	0.289810981048613	0.655160429048568
GO:0046624	sphingolipid transporter activity	6/4447	19/18639	0.315789473684211	1.32358893636159	0.289810981048613	0.655160429048568
GO:0120227	acyl-CoA binding	6/4447	19/18639	0.315789473684211	1.32358893636159	0.289810981048613	0.655160429048568
GO:0015605	organophosphate ester transmembrane transporter activity	14/4447	50/18639	0.28	1.17358219024061	0.293784068739691	0.661887027534075
GO:0032813	tumor necrosis factor receptor superfamily binding	14/4447	50/18639	0.28	1.17358219024061	0.293784068739691	0.661887027534075
GO:0050661	NADP binding	15/4447	54/18639	0.277777777777778	1.16426804587362	0.295741813449805	0.665168451606595
GO:0008171	O-methyltransferase activity	7/4447	23/18639	0.304347826086957	1.27563281547893	0.299112117028414	0.669345327650431
GO:0031681	G-protein beta-subunit binding	7/4447	23/18639	0.304347826086957	1.27563281547893	0.299112117028414	0.669345327650431
GO:0140102	catalytic activity, acting on a rRNA	7/4447	23/18639	0.304347826086957	1.27563281547893	0.299112117028414	0.669345327650431
GO:0070851	growth factor receptor binding	36/4447	139/18639	0.258992805755396	1.08553337226778	0.315636898733565	0.693447817255395
GO:0003720	telomerase activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0004526	ribonuclease P activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0005078	MAP-kinase scaffold activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0005095	GTPase inhibitor activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0017166	vinculin binding	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0031543	peptidyl-proline dioxygenase activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0035197	siRNA binding	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0035251	UDP-glucosyltransferase activity	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0035259	nuclear glucocorticoid receptor binding	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0070679	inositol 1,4,5 trisphosphate binding	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0097677	STAT family protein binding	4/4447	12/18639	0.333333333333333	1.39712165504835	0.316153677045602	0.693447817255395
GO:0000217	DNA secondary structure binding	11/4447	39/18639	0.282051282051282	1.18217986196399	0.317402542383679	0.695038240500235
GO:0008200	ion channel inhibitor activity	12/4447	43/18639	0.27906976744186	1.16968324608699	0.31957495099913	0.698642438180964
GO:0030165	PDZ domain binding	22/4447	83/18639	0.265060240963855	1.11096420762881	0.324265277902839	0.707730302264914
GO:0000062	fatty-acyl-CoA binding	5/4447	16/18639	0.3125	1.30980155160783	0.329032523874291	0.71227758430862
GO:0008142	oxysterol binding	5/4447	16/18639	0.3125	1.30980155160783	0.329032523874291	0.71227758430862
GO:0008296	3'-5'-DNA exonuclease activity	5/4447	16/18639	0.3125	1.30980155160783	0.329032523874291	0.71227758430862
GO:0030275	LRR domain binding	5/4447	16/18639	0.3125	1.30980155160783	0.329032523874291	0.71227758430862
GO:0140328	floppase activity	5/4447	16/18639	0.3125	1.30980155160783	0.329032523874291	0.71227758430862
GO:0002020	protease binding	35/4447	136/18639	0.257352941176471	1.07866010132409	0.334116871174488	0.722106006593723
GO:0016004	phospholipase activator activity	6/4447	20/18639	0.3	1.25740948954351	0.337043766583033	0.726066685480008
GO:0031418	L-ascorbic acid binding	6/4447	20/18639	0.3	1.25740948954351	0.337043766583033	0.726066685480008
GO:0005540	hyaluronic acid binding	7/4447	24/18639	0.291666666666667	1.2224814481673	0.342301827688846	0.735007322561649
GO:0060229	lipase activator activity	7/4447	24/18639	0.291666666666667	1.2224814481673	0.342301827688846	0.735007322561649
GO:0022884	macromolecule transmembrane transporter activity	9/4447	32/18639	0.28125	1.17882139644704	0.34824714343249	0.745297940833032
GO:0030515	snoRNA binding	9/4447	32/18639	0.28125	1.17882139644704	0.34824714343249	0.745297940833032
GO:0098631	cell adhesion mediator activity	20/4447	76/18639	0.263157894736842	1.10299078030133	0.348779217224802	0.745297940833032
GO:0004177	aminopeptidase activity	11/4447	40/18639	0.275	1.15262536541489	0.35088064727201	0.748030893099767
GO:0016248	channel inhibitor activity	12/4447	44/18639	0.272727272727273	1.14309953594865	0.35147885918223	0.748030893099767
GO:0038187	pattern recognition receptor activity	13/4447	48/18639	0.270833333333333	1.13516134472678	0.351749266988888	0.748030893099767
GO:1990782	protein tyrosine kinase binding	30/4447	117/18639	0.256410256410256	1.07470896542181	0.358947391292629	0.762117101192511
GO:0016874	ligase activity	42/4447	167/18639	0.251497005988024	1.05411573973708	0.375966516294162	0.788865467184569
GO:0002161	aminoacyl-tRNA editing activity	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0003964	RNA-directed DNA polymerase activity	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0043560	insulin receptor substrate binding	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0070123	transforming growth factor beta receptor activity, type III	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0070700	BMP receptor binding	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0086080	protein binding involved in heterotypic cell-cell adhesion	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0089720	caspase binding	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0140333	glycerophospholipid flippase activity	4/4447	13/18639	0.307692307692308	1.28965075850617	0.377490257469632	0.788865467184569
GO:0022853	active monoatomic ion transmembrane transporter activity	30/4447	118/18639	0.254237288135593	1.06560126232501	0.378769317933638	0.789635845279379
GO:0005544	calcium-dependent phospholipid binding	14/4447	53/18639	0.264150943396226	1.10715300966095	0.381520871860428	0.789635845279379
GO:0004549	tRNA-specific ribonuclease activity	5/4447	17/18639	0.294117647058824	1.23275440151325	0.382478933397434	0.789635845279379
GO:0005092	GDP-dissociation inhibitor activity	5/4447	17/18639	0.294117647058824	1.23275440151325	0.382478933397434	0.789635845279379
GO:0030169	low-density lipoprotein particle binding	5/4447	17/18639	0.294117647058824	1.23275440151325	0.382478933397434	0.789635845279379
GO:1901567	fatty acid derivative binding	5/4447	17/18639	0.294117647058824	1.23275440151325	0.382478933397434	0.789635845279379
GO:0035254	glutamate receptor binding	13/4447	49/18639	0.26530612244898	1.11199478667113	0.382743194650398	0.789635845279379
GO:0046915	transition metal ion transmembrane transporter activity	12/4447	45/18639	0.266666666666667	1.11769732403868	0.383871749018043	0.789635845279379
GO:0141110	transporter inhibitor activity	12/4447	45/18639	0.266666666666667	1.11769732403868	0.383871749018043	0.789635845279379
GO:0140828	metal cation:monoatomic cation antiporter activity	11/4447	41/18639	0.268292682926829	1.12451255162428	0.384871750702907	0.789635845279379
GO:0008373	sialyltransferase activity	6/4447	21/18639	0.285714285714286	1.1975328471843	0.384999541745108	0.789635845279379
GO:1904047	S-adenosyl-L-methionine binding	6/4447	21/18639	0.285714285714286	1.1975328471843	0.384999541745108	0.789635845279379
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	7/4447	25/18639	0.28	1.17358219024061	0.386152782912169	0.790778924266125
GO:0016757	glycosyltransferase activity	66/4447	267/18639	0.247191011235955	1.03606774419316	0.393074737155314	0.803713676741297
GO:0031492	nucleosomal DNA binding	11/4447	42/18639	0.261904761904762	1.09773844325227	0.419104814747814	0.842366509931443
GO:0031210	phosphatidylcholine binding	8/4447	30/18639	0.266666666666667	1.11769732403868	0.427260767524515	0.842366509931443
GO:0033612	receptor serine/threonine kinase binding	8/4447	30/18639	0.266666666666667	1.11769732403868	0.427260767524515	0.842366509931443
GO:0140299	molecular sensor activity	18/4447	71/18639	0.253521126760563	1.06259956862832	0.428648896209047	0.842366509931443
GO:0008157	protein phosphatase 1 binding	7/4447	26/18639	0.269230769230769	1.1284444136929	0.430088547117336	0.842366509931443
GO:0015216	purine nucleotide transmembrane transporter activity	7/4447	26/18639	0.269230769230769	1.1284444136929	0.430088547117336	0.842366509931443
GO:0120014	phospholipid transfer activity	7/4447	26/18639	0.269230769230769	1.1284444136929	0.430088547117336	0.842366509931443
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	17/4447	67/18639	0.253731343283582	1.063480662798	0.431692113882269	0.842366509931443
GO:0003746	translation elongation factor activity	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0008308	voltage-gated monoatomic anion channel activity	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0008525	phosphatidylcholine transporter activity	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0017075	syntaxin-1 binding	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0031690	adrenergic receptor binding	5/4447	18/18639	0.277777777777778	1.16426804587362	0.435698828309361	0.842366509931443
GO:0043178	alcohol binding	23/4447	92/18639	0.25	1.04784124128626	0.438162633072908	0.842366509931443
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	15/4447	59/18639	0.254237288135593	1.06560126232501	0.438177356760627	0.842366509931443
GO:0070888	E-box binding	15/4447	59/18639	0.254237288135593	1.06560126232501	0.438177356760627	0.842366509931443
GO:0008174	mRNA methyltransferase activity	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0008559	ABC-type xenobiotic transporter activity	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0015386	potassium:proton antiporter activity	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0032036	myosin heavy chain binding	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0052816	long-chain fatty acyl-CoA hydrolase activity	4/4447	14/18639	0.285714285714286	1.1975328471843	0.438207412854589	0.842366509931443
GO:0001164	RNA polymerase I core promoter sequence-specific DNA binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0004090	carbonyl reductase (NADPH) activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0004445	inositol-polyphosphate 5-phosphatase activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0004862	cAMP-dependent protein kinase inhibitor activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0008190	eukaryotic initiation factor 4E binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0015279	store-operated calcium channel activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0016427	tRNA (cytidine) methyltransferase activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0031078	histone H3K14 deacetylase activity, hydrolytic mechanism	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0031434	mitogen-activated protein kinase kinase binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0032356	oxidized DNA binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0034739	histone H4K16 deacetylase activity, hydrolytic mechanism	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0042975	peroxisome proliferator activated receptor binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0043225	ATPase-coupled inorganic anion transmembrane transporter activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0043295	glutathione binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0047429	nucleoside triphosphate diphosphatase activity	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0050815	phosphoserine residue binding	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0180032	histone H4K5 deacetylase activity, hydrolytic mechanism	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0180033	histone H4K8 deacetylase activity, hydrolytic mechanism	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:1990162	histone H3K4 deacetylase activity, hydrolytic mechanism	3/4447	10/18639	0.3	1.25740948954351	0.439909563965705	0.842366509931443
GO:0008374	O-acyltransferase activity	14/4447	55/18639	0.254545454545455	1.06689290021874	0.441653800294072	0.843272795669401
GO:0098632	cell-cell adhesion mediator activity	14/4447	55/18639	0.254545454545455	1.06689290021874	0.441653800294072	0.843272795669401
GO:0017022	myosin binding	19/4447	76/18639	0.25	1.04784124128626	0.451367463093894	0.860581355640226
GO:0008375	acetylglucosaminyltransferase activity	11/4447	43/18639	0.255813953488372	1.07220964224641	0.453318205411425	0.861824152694786
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	11/4447	43/18639	0.255813953488372	1.07220964224641	0.453318205411425	0.861824152694786
GO:0033218	amide binding	60/4447	247/18639	0.242914979757085	1.01814533566276	0.460884727263687	0.874955698253094
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	15/4447	60/18639	0.25	1.04784124128626	0.46715805931823	0.882970298771104
GO:0005164	tumor necrosis factor receptor binding	8/4447	31/18639	0.258064516129032	1.08164257165033	0.467767987969922	0.882970298771104
GO:0016411	acylglycerol O-acyltransferase activity	8/4447	31/18639	0.258064516129032	1.08164257165033	0.467767987969922	0.882970298771104
GO:0017147	Wnt-protein binding	8/4447	31/18639	0.258064516129032	1.08164257165033	0.467767987969922	0.882970298771104
GO:0019212	phosphatase inhibitor activity	14/4447	56/18639	0.25	1.04784124128626	0.471678302099066	0.886376675274594
GO:0008013	beta-catenin binding	26/4447	106/18639	0.245283018867925	1.02807065182803	0.473023082318342	0.886376675274594
GO:0004364	glutathione transferase activity	7/4447	27/18639	0.259259259259259	1.08665017614871	0.47358030351898	0.886376675274594
GO:0005044	scavenger receptor activity	7/4447	27/18639	0.259259259259259	1.08665017614871	0.47358030351898	0.886376675274594
GO:0008320	protein transmembrane transporter activity	7/4447	27/18639	0.259259259259259	1.08665017614871	0.47358030351898	0.886376675274594
GO:0035255	ionotropic glutamate receptor binding	7/4447	27/18639	0.259259259259259	1.08665017614871	0.47358030351898	0.886376675274594
GO:0000295	adenine nucleotide transmembrane transporter activity	6/4447	23/18639	0.260869565217391	1.09339955612479	0.480156848767797	0.897419913119531
GO:0022821	solute:potassium antiporter activity	5/4447	19/18639	0.263157894736842	1.10299078030133	0.487801630902486	0.909147140741009
GO:0070003	threonine-type peptidase activity	5/4447	19/18639	0.263157894736842	1.10299078030133	0.487801630902486	0.909147140741009
GO:0004129	cytochrome-c oxidase activity	4/4447	15/18639	0.266666666666667	1.11769732403868	0.49704948615476	0.916426948197407
GO:0005041	low-density lipoprotein particle receptor activity	4/4447	15/18639	0.266666666666667	1.11769732403868	0.49704948615476	0.916426948197407
GO:0016846	carbon-sulfur lyase activity	4/4447	15/18639	0.266666666666667	1.11769732403868	0.49704948615476	0.916426948197407
GO:0031005	filamin binding	4/4447	15/18639	0.266666666666667	1.11769732403868	0.49704948615476	0.916426948197407
GO:0016409	palmitoyltransferase activity	9/4447	36/18639	0.25	1.04784124128626	0.500090362892766	0.916426948197407
GO:0015399	primary active transmembrane transporter activity	40/4447	166/18639	0.240963855421687	1.00996746148073	0.501406781072128	0.916426948197407
GO:0004601	peroxidase activity	14/4447	57/18639	0.245614035087719	1.02945806161457	0.501452220534493	0.916426948197407
GO:1901505	carbohydrate derivative transmembrane transporter activity	13/4447	53/18639	0.245283018867925	1.02807065182803	0.507366914455591	0.916426948197407
GO:0043425	bHLH transcription factor binding	8/4447	32/18639	0.25	1.04784124128626	0.507608269482399	0.916426948197407
GO:0016829	lyase activity	48/4447	200/18639	0.24	1.00592759163481	0.508755834103119	0.916426948197407
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0002162	dystroglycan binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0005114	type II transforming growth factor beta receptor binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0008172	S-methyltransferase activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0008526	phosphatidylinositol transfer activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0015217	ADP transmembrane transporter activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0019206	nucleoside kinase activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0032050	clathrin heavy chain binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0034511	U3 snoRNA binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0035252	UDP-xylosyltransferase activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0042285	xylosyltransferase activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0045294	alpha-catenin binding	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0047676	arachidonate-CoA ligase activity	3/4447	11/18639	0.272727272727273	1.14309953594865	0.508972615539931	0.916426948197407
GO:0016866	intramolecular transferase activity	7/4447	28/18639	0.25	1.04784124128626	0.516158721018572	0.927125965291159
GO:0005496	steroid binding	26/4447	108/18639	0.240740740740741	1.00903230642381	0.516312048492966	0.927125965291159
GO:0008235	metalloexopeptidase activity	16/4447	66/18639	0.242424242424242	1.0160884763988	0.518377358803978	0.929576696125511
GO:0070696	transmembrane receptor protein serine/threonine kinase binding	6/4447	24/18639	0.25	1.04784124128626	0.526108522460782	0.940897586665037
GO:0070840	dynein complex binding	6/4447	24/18639	0.25	1.04784124128626	0.526108522460782	0.940897586665037
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	10/4447	41/18639	0.24390243902439	1.02228413784025	0.528362065128687	0.943656070559579
GO:0140939	histone H4 methyltransferase activity	5/4447	20/18639	0.25	1.04784124128626	0.538054252342303	0.959674721583651
GO:0005024	transforming growth factor beta receptor activity	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0005149	interleukin-1 receptor binding	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0005324	long-chain fatty acid transmembrane transporter activity	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0015385	sodium:proton antiporter activity	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0016675	oxidoreductase activity, acting on a heme group of donors	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0022858	alanine transmembrane transporter activity	4/4447	16/18639	0.25	1.04784124128626	0.553055140248249	0.977956226561939
GO:0004180	carboxypeptidase activity	11/4447	46/18639	0.239130434782609	1.00228292644773	0.553462792877178	0.977956226561939
GO:0016417	S-acyltransferase activity	7/4447	29/18639	0.241379310344828	1.01170878469018	0.557421232248069	0.981544393052232
GO:0048487	beta-tubulin binding	10/4447	42/18639	0.238095238095238	0.997944039320248	0.56250495587271	0.981544393052232
GO:0008238	exopeptidase activity	24/4447	102/18639	0.235294117647059	0.986203521210598	0.569465554272225	0.981544393052232
GO:0003707	nuclear steroid receptor activity	6/4447	25/18639	0.24	1.00592759163481	0.570305071791922	0.981544393052232
GO:0120020	cholesterol transfer activity	6/4447	25/18639	0.24	1.00592759163481	0.570305071791922	0.981544393052232
GO:0042887	amide transmembrane transporter activity	9/4447	38/18639	0.236842105263158	0.992691702271194	0.572582040652824	0.981544393052232
GO:0003995	acyl-CoA dehydrogenase activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0004000	adenosine deaminase activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0004859	phospholipase inhibitor activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0005025	transforming growth factor beta receptor activity, type I	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0005026	transforming growth factor beta receptor activity, type II	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0005165	neurotrophin receptor binding	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0008603	cAMP-dependent protein kinase regulator activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0015368	calcium:monoatomic cation antiporter activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0016273	arginine N-methyltransferase activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0016274	protein-arginine N-methyltransferase activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0016361	activin receptor activity, type I	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0016362	activin receptor activity, type II	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0017002	activin receptor activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0034452	dynactin binding	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0045295	gamma-catenin binding	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0070008	serine-type exopeptidase activity	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0070410	co-SMAD binding	3/4447	12/18639	0.25	1.04784124128626	0.57324559503804	0.981544393052232
GO:0004857	enzyme inhibitor activity	98/4447	416/18639	0.235576923076923	0.987388861981284	0.577081380174514	0.986838906561315
GO:0003735	structural constituent of ribosome	41/4447	175/18639	0.234285714285714	0.981976934691124	0.582584337719284	0.994204434985948
GO:0016831	carboxy-lyase activity	8/4447	34/18639	0.235294117647059	0.986203521210598	0.58396382219072	0.994204434985948
GO:0030332	cyclin binding	8/4447	34/18639	0.235294117647059	0.986203521210598	0.58396382219072	0.994204434985948
GO:0043495	protein-membrane adaptor activity	11/4447	47/18639	0.234042553191489	0.980957757799903	0.585323480963928	0.994204434985948
GO:0001846	opsonin binding	5/4447	21/18639	0.238095238095238	0.997944039320248	0.585883849403927	0.994204434985948
GO:0070182	DNA polymerase binding	5/4447	21/18639	0.238095238095238	0.997944039320248	0.585883849403927	0.994204434985948
GO:0003779	actin binding	104/4447	443/18639	0.234762979683973	0.983977328160461	0.594294092598146	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	7/4447	30/18639	0.233333333333333	0.977985158533843	0.597035286729151	1
GO:0004029	aldehyde dehydrogenase (NAD+) activity	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0004550	nucleoside diphosphate kinase activity	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0008429	phosphatidylethanolamine binding	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0015278	intracellularly gated calcium channel activity	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0016018	cyclosporin A binding	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0036041	long-chain fatty acid binding	4/4447	17/18639	0.235294117647059	0.986203521210598	0.605540126971576	1
GO:0038024	cargo receptor activity	15/4447	65/18639	0.230769230769231	0.967238068879625	0.606442398401992	1
GO:0015078	proton transmembrane transporter activity	43/4447	185/18639	0.232432432432432	0.974209154060739	0.606493678719396	1
GO:0048029	monosaccharide binding	17/4447	74/18639	0.22972972972973	0.962881140641428	0.615539447384003	1
GO:0016229	steroid dehydrogenase activity	8/4447	35/18639	0.228571428571429	0.958026277747438	0.619943953492499	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	13/4447	57/18639	0.228070175438596	0.955925342927817	0.624532431306329	1
GO:0008970	phospholipase A1 activity	5/4447	22/18639	0.227272727272727	0.952582946623873	0.630870926195069	1
GO:0052689	carboxylic ester hydrolase activity	21/4447	92/18639	0.228260869565217	0.956724611609194	0.631751333180443	1
GO:0005172	vascular endothelial growth factor receptor binding	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0005542	folic acid binding	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0019104	DNA N-glycosylase activity	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0035325	Toll-like receptor binding	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0039706	co-receptor binding	3/4447	13/18639	0.230769230769231	0.967238068879625	0.631972196308563	1
GO:0004864	protein phosphatase inhibitor activity	12/4447	53/18639	0.226415094339623	0.948988293995104	0.634694720062253	1
GO:0016878	acid-thiol ligase activity	7/4447	31/18639	0.225806451612903	0.946437250194042	0.634738248867259	1
GO:0050997	quaternary ammonium group binding	9/4447	40/18639	0.225	0.943057117157635	0.640034337992945	1
GO:0051015	actin filament binding	48/4447	209/18639	0.229665071770335	0.962610135535703	0.645737086782822	1
GO:0005385	zinc ion transmembrane transporter activity	6/4447	27/18639	0.222222222222222	0.931414436698898	0.652024236530103	1
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	4/4447	18/18639	0.222222222222222	0.931414436698898	0.654066212303638	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	4/4447	18/18639	0.222222222222222	0.931414436698898	0.654066212303638	1
GO:0030228	lipoprotein particle receptor activity	4/4447	18/18639	0.222222222222222	0.931414436698898	0.654066212303638	1
GO:0004033	aldo-keto reductase (NADPH) activity	8/4447	36/18639	0.222222222222222	0.931414436698898	0.654187836520993	1
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	7/4447	32/18639	0.21875	0.916861086125478	0.67033464309502	1
GO:0001530	lipopolysaccharide binding	9/4447	41/18639	0.219512195121951	0.920055724056229	0.671442164736018	1
GO:0017080	sodium channel regulator activity	9/4447	41/18639	0.219512195121951	0.920055724056229	0.671442164736018	1
GO:0004602	glutathione peroxidase activity	5/4447	23/18639	0.217391304347826	0.911166296770661	0.672735947702644	1
GO:0030971	receptor tyrosine kinase binding	18/4447	81/18639	0.222222222222222	0.931414436698898	0.676804107955916	1
GO:0008191	metalloendopeptidase inhibitor activity	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0016530	metallochaperone activity	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0042043	neurexin family protein binding	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0042813	Wnt receptor activity	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0044548	S100 protein binding	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0098821	BMP receptor activity	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:1901612	cardiolipin binding	3/4447	14/18639	0.214285714285714	0.898149635388223	0.684817137250556	1
GO:0042805	actinin binding	8/4447	37/18639	0.216216216216216	0.906241073544874	0.68655394160186	1
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	6/4447	28/18639	0.214285714285714	0.898149635388223	0.689078468033248	1
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	19/4447	86/18639	0.22093023255814	0.925999236485533	0.689708071244559	1
GO:0004521	RNA endonuclease activity	16/4447	73/18639	0.219178082191781	0.91865533482631	0.694774477186649	1
GO:0015245	fatty acid transmembrane transporter activity	4/4447	19/18639	0.210526315789474	0.882392624241061	0.698403434010612	1
GO:0016830	carbon-carbon lyase activity	11/4447	51/18639	0.215686274509804	0.904019894443048	0.701107431791809	1
GO:0019894	kinesin binding	9/4447	42/18639	0.214285714285714	0.898149635388223	0.701152312607829	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	7/4447	33/18639	0.212121212121212	0.889077416848948	0.703691427234963	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	27/4447	122/18639	0.221311475409836	0.927597164417345	0.706298005272036	1
GO:0005315	phosphate transmembrane transporter activity	5/4447	24/18639	0.208333333333333	0.873201034405217	0.711322112239976	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	5/4447	24/18639	0.208333333333333	0.873201034405217	0.711322112239976	1
GO:0030552	cAMP binding	5/4447	24/18639	0.208333333333333	0.873201034405217	0.711322112239976	1
GO:0050699	WW domain binding	5/4447	24/18639	0.208333333333333	0.873201034405217	0.711322112239976	1
GO:0070300	phosphatidic acid binding	5/4447	24/18639	0.208333333333333	0.873201034405217	0.711322112239976	1
GO:0003774	cytoskeletal motor activity	34/4447	153/18639	0.222222222222222	0.931414436698898	0.712526661088715	1
GO:0140359	ABC-type transporter activity	10/4447	47/18639	0.212765957446809	0.891779779818094	0.714446124862186	1
GO:0005109	frizzled binding	8/4447	38/18639	0.210526315789474	0.882392624241061	0.716946448521603	1
GO:0099604	ligand-gated calcium channel activity	6/4447	29/18639	0.206896551724138	0.867178958305871	0.723423833890251	1
GO:0016782	transferase activity, transferring sulphur-containing groups	15/4447	70/18639	0.214285714285714	0.898149635388223	0.726622128825684	1
GO:0000182	rDNA binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0001094	TFIID-class transcription factor complex binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0003680	minor groove of adenine-thymine-rich DNA binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0004382	GDP phosphatase activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0005131	growth hormone receptor binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0005522	profilin binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0015187	glycine transmembrane transporter activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0015643	toxic substance binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0016868	intramolecular phosphotransferase activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0019531	oxalate transmembrane transporter activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0031419	cobalamin binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0031956	medium-chain fatty acid-CoA ligase activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0031957	very long-chain fatty acid-CoA ligase activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0035256	G protein-coupled glutamate receptor binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0035374	chondroitin sulfate binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0045322	unmethylated CpG binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0051880	G-quadruplex DNA binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0070513	death domain binding	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0140135	mechanosensitive monoatomic cation channel activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0141109	transporter activator activity	2/4447	10/18639	0.2	0.838272993029008	0.729352890799509	1
GO:0004467	long-chain fatty acid-CoA ligase activity	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0005523	tropomyosin binding	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0033130	acetylcholine receptor binding	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0045504	dynein heavy chain binding	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0050780	dopamine receptor binding	3/4447	15/18639	0.2	0.838272993029008	0.731759050024505	1
GO:0042288	MHC class I protein binding	4/4447	20/18639	0.2	0.838272993029008	0.738490729427689	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	10/4447	48/18639	0.208333333333333	0.873201034405217	0.740316491069211	1
GO:0001848	complement binding	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0005537	D-mannose binding	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0015645	fatty acid ligase activity	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0019706	protein-cysteine S-palmitoyltransferase activity	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0019707	protein-cysteine S-acyltransferase activity	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0120515	fatty acid-CoA ligase activity	5/4447	25/18639	0.2	0.838272993029008	0.74657637235199	1
GO:0048306	calcium-dependent protein binding	17/4447	80/18639	0.2125	0.890665055093321	0.747703400818954	1
GO:0005246	calcium channel regulator activity	11/4447	53/18639	0.207547169811321	0.869905936162178	0.750746232179985	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	28/4447	130/18639	0.215384615384615	0.902755530954317	0.763449883670259	1
GO:0001618	virus receptor activity	17/4447	81/18639	0.209876543209877	0.879669190215626	0.766536025485699	1
GO:0005507	copper ion binding	13/4447	63/18639	0.206349206349206	0.864884834077548	0.769624849191999	1
GO:0071949	FAD binding	8/4447	40/18639	0.2	0.838272993029008	0.771630231120768	1
GO:0055102	lipase inhibitor activity	3/4447	16/18639	0.1875	0.785880930964695	0.772998413819026	1
GO:0009975	cyclase activity	4/4447	21/18639	0.19047619047619	0.798355231456198	0.774398230609751	1
GO:0051428	peptide hormone receptor binding	4/4447	21/18639	0.19047619047619	0.798355231456198	0.774398230609751	1
GO:0004016	adenylate cyclase activity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0004143	ATP-dependent diacylglycerol kinase activity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0005536	D-glucose binding	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0008271	secondary active sulfate transmembrane transporter activity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0010854	adenylate cyclase regulator activity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0032794	GTPase activating protein binding	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0043522	leucine zipper domain binding	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0050786	RAGE receptor binding	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0070697	activin receptor binding	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0097493	structural molecule activity conferring elasticity	2/4447	11/18639	0.181818181818182	0.762066357299098	0.778326285301638	1
GO:0005112	Notch binding	5/4447	26/18639	0.192307692307692	0.806031724066354	0.778530263580012	1
GO:0008327	methyl-CpG binding	6/4447	31/18639	0.193548387096774	0.81123192873775	0.78388882391571	1
GO:0072349	modified amino acid transmembrane transporter activity	6/4447	31/18639	0.193548387096774	0.81123192873775	0.78388882391571	1
GO:0140272	exogenous protein binding	17/4447	82/18639	0.207317073170732	0.868941517164216	0.784402218812759	1
GO:0005516	calmodulin binding	45/4447	207/18639	0.217391304347826	0.911166296770661	0.787094935731566	1
GO:0046982	protein heterodimerization activity	82/4447	369/18639	0.222222222222222	0.931414436698898	0.788998923016001	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	28/4447	132/18639	0.212121212121212	0.889077416848948	0.791744227330186	1
GO:0004812	aminoacyl-tRNA ligase activity	8/4447	41/18639	0.195121951219512	0.817827310272203	0.795918247214041	1
GO:0016875	ligase activity, forming carbon-oxygen bonds	8/4447	41/18639	0.195121951219512	0.817827310272203	0.795918247214041	1
GO:0001540	amyloid-beta binding	17/4447	83/18639	0.204819277108434	0.858472342258623	0.801300561900455	1
GO:0031683	G-protein beta/gamma-subunit complex binding	4/4447	22/18639	0.181818181818182	0.762066357299098	0.806293187146347	1
GO:0061133	endopeptidase activator activity	4/4447	22/18639	0.181818181818182	0.762066357299098	0.806293187146347	1
GO:0004683	calcium/calmodulin-dependent protein kinase activity	5/4447	27/18639	0.185185185185185	0.776178697249082	0.807281633364082	1
GO:0016405	CoA-ligase activity	5/4447	27/18639	0.185185185185185	0.776178697249082	0.807281633364082	1
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	3/4447	17/18639	0.176470588235294	0.739652640907949	0.808882332429193	1
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	3/4447	17/18639	0.176470588235294	0.739652640907949	0.808882332429193	1
GO:0017110	nucleoside diphosphate phosphatase activity	3/4447	17/18639	0.176470588235294	0.739652640907949	0.808882332429193	1
GO:0019198	transmembrane receptor protein phosphatase activity	3/4447	17/18639	0.176470588235294	0.739652640907949	0.808882332429193	1
GO:0071813	lipoprotein particle binding	6/4447	32/18639	0.1875	0.785880930964695	0.810093634874332	1
GO:0071814	protein-lipid complex binding	6/4447	32/18639	0.1875	0.785880930964695	0.810093634874332	1
GO:1902936	phosphatidylinositol bisphosphate binding	23/4447	111/18639	0.207207207207207	0.868481028813837	0.812116154265516	1
GO:0030551	cyclic nucleotide binding	7/4447	37/18639	0.189189189189189	0.792960939351765	0.813887593340837	1
GO:0004032	aldose reductase (NADPH) activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0005436	sodium:phosphate symporter activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0010853	cyclase activator activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0015269	calcium-activated potassium channel activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0016840	carbon-nitrogen lyase activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0042301	phosphate ion binding	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0097371	MDM2/MDM4 family protein binding	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0140829	bicarbonate:monoatomic anion antiporter activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0140900	chloride:bicarbonate antiporter activity	2/4447	12/18639	0.166666666666667	0.698560827524174	0.819342423354357	1
GO:0015297	antiporter activity	28/4447	135/18639	0.207407407407407	0.869320140918971	0.829725099044705	1
GO:0051393	alpha-actinin binding	5/4447	28/18639	0.178571428571429	0.748458029490186	0.832977973653394	1
GO:0051959	dynein light intermediate chain binding	5/4447	28/18639	0.178571428571429	0.748458029490186	0.832977973653394	1
GO:0019239	deaminase activity	6/4447	33/18639	0.181818181818182	0.762066357299098	0.833738569905302	1
GO:0017134	fibroblast growth factor binding	4/4447	23/18639	0.173913043478261	0.728933037416529	0.834410500713443	1
GO:0043274	phospholipase binding	4/4447	23/18639	0.173913043478261	0.728933037416529	0.834410500713443	1
GO:0140103	catalytic activity, acting on a glycoprotein	4/4447	23/18639	0.173913043478261	0.728933037416529	0.834410500713443	1
GO:0000146	microfilament motor activity	7/4447	38/18639	0.184210526315789	0.772093546210929	0.835777529267761	1
GO:0015172	acidic amino acid transmembrane transporter activity	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:0016854	racemase and epimerase activity	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:0034185	apolipoprotein binding	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:0050811	GABA receptor binding	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:1901611	phosphatidylglycerol binding	3/4447	18/18639	0.166666666666667	0.698560827524174	0.839845556454305	1
GO:0005506	iron ion binding	32/4447	154/18639	0.207792207792208	0.870932979770398	0.840235780312719	1
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	18/4447	91/18639	0.197802197802198	0.829061201896821	0.851014874080946	1
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0005035	death receptor activity	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0008035	high-density lipoprotein particle binding	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0031432	titin binding	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0031994	insulin-like growth factor I binding	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0045159	myosin II binding	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0061459	L-arginine transmembrane transporter activity	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0071837	HMG box domain binding	2/4447	13/18639	0.153846153846154	0.644825379253083	0.853409737362683	1
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	6/4447	34/18639	0.176470588235294	0.739652640907949	0.854954281149663	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6/4447	34/18639	0.176470588235294	0.739652640907949	0.854954281149663	1
GO:0004181	metallocarboxypeptidase activity	5/4447	29/18639	0.172413793103448	0.722649131921559	0.855801752770715	1
GO:0042625	ATPase-coupled ion transmembrane transporter activity	4/4447	24/18639	0.166666666666667	0.698560827524174	0.859028178408136	1
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4/4447	24/18639	0.166666666666667	0.698560827524174	0.859028178408136	1
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4/4447	24/18639	0.166666666666667	0.698560827524174	0.859028178408136	1
GO:0001786	phosphatidylserine binding	11/4447	59/18639	0.186440677966102	0.781440925705008	0.864605872957655	1
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0005520	insulin-like growth factor binding	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0008381	mechanosensitive monoatomic ion channel activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0022840	leak channel activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0022842	narrow pore channel activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0030506	ankyrin binding	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0031420	alkali metal ion binding	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0042577	lipid phosphatase activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0042800	histone H3K4 methyltransferase activity	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0042834	peptidoglycan binding	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0043395	heparan sulfate proteoglycan binding	3/4447	19/18639	0.157894736842105	0.661794468180796	0.866365954412497	1
GO:0015296	monoatomic anion:monoatomic cation symporter activity	4/4447	25/18639	0.16	0.670618394423207	0.880447570037878	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	37/4447	181/18639	0.204419889502762	0.856798363040699	0.88055934807509	1
GO:0005313	L-glutamate transmembrane transporter activity	2/4447	14/18639	0.142857142857143	0.598766423592149	0.881508504048037	1
GO:0030283	testosterone dehydrogenase [NAD(P)+] activity	2/4447	14/18639	0.142857142857143	0.598766423592149	0.881508504048037	1
GO:0031404	chloride ion binding	2/4447	14/18639	0.142857142857143	0.598766423592149	0.881508504048037	1
GO:0001972	retinoic acid binding	3/4447	20/18639	0.15	0.628704744771756	0.888932170586287	1
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	3/4447	20/18639	0.15	0.628704744771756	0.888932170586287	1
GO:0015175	neutral L-amino acid transmembrane transporter activity	7/4447	41/18639	0.170731707317073	0.715598896488178	0.88931818636647	1
GO:0042169	SH2 domain binding	7/4447	41/18639	0.170731707317073	0.715598896488178	0.88931818636647	1
GO:0005021	vascular endothelial growth factor receptor activity	9/4447	51/18639	0.176470588235294	0.739652640907949	0.889425393160908	1
GO:0030170	pyridoxal phosphate binding	10/4447	56/18639	0.178571428571429	0.748458029490186	0.890386979900288	1
GO:0045505	dynein intermediate chain binding	6/4447	36/18639	0.166666666666667	0.698560827524174	0.890709189593762	1
GO:0005452	solute:inorganic anion antiporter activity	5/4447	31/18639	0.161290322580645	0.676026607281458	0.893663502510492	1
GO:0047499	calcium-independent phospholipase A2 activity	5/4447	31/18639	0.161290322580645	0.676026607281458	0.893663502510492	1
GO:0016758	hexosyltransferase activity	40/4447	197/18639	0.203045685279188	0.851038571603054	0.897995565719121	1
GO:0005227	calcium-activated cation channel activity	4/4447	26/18639	0.153846153846154	0.644825379253083	0.898977989393853	1
GO:0050660	flavin adenine dinucleotide binding	16/4447	86/18639	0.186046511627907	0.779788830724659	0.90130503172693	1
GO:0070279	vitamin B6 binding	10/4447	57/18639	0.175438596491228	0.735327186867551	0.902740221174045	1
GO:0072341	modified amino acid binding	17/4447	91/18639	0.186813186813187	0.783002246235887	0.90346453022558	1
GO:0005402	carbohydrate:monoatomic cation symporter activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0008242	omega peptidase activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0015116	sulfate transmembrane transporter activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0015929	hexosaminidase activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0017081	chloride channel regulator activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0034483	heparan sulfate sulfotransferase activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0048531	beta-1,3-galactosyltransferase activity	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0051371	muscle alpha-actinin binding	2/4447	15/18639	0.133333333333333	0.558848662019339	0.904546881590119	1
GO:0005248	voltage-gated sodium channel activity	3/4447	21/18639	0.142857142857143	0.598766423592149	0.908021160582376	1
GO:0015174	basic amino acid transmembrane transporter activity	3/4447	21/18639	0.142857142857143	0.598766423592149	0.908021160582376	1
GO:0019200	carbohydrate kinase activity	3/4447	21/18639	0.142857142857143	0.598766423592149	0.908021160582376	1
GO:0047498	calcium-dependent phospholipase A2 activity	5/4447	32/18639	0.15625	0.654900775803913	0.909139403924595	1
GO:0042277	peptide binding	51/4447	249/18639	0.204819277108434	0.858472342258623	0.91059643972036	1
GO:0019955	cytokine binding	28/4447	144/18639	0.194444444444444	0.814987632111536	0.913332027078107	1
GO:0005003	ephrin receptor activity	9/4447	53/18639	0.169811320754717	0.711741220496328	0.914023283987552	1
GO:0005005	transmembrane-ephrin receptor activity	9/4447	53/18639	0.169811320754717	0.711741220496328	0.914023283987552	1
GO:0008146	sulfotransferase activity	9/4447	53/18639	0.169811320754717	0.711741220496328	0.914023283987552	1
GO:0038064	collagen receptor activity	9/4447	53/18639	0.169811320754717	0.711741220496328	0.914023283987552	1
GO:0023026	MHC class II protein complex binding	4/4447	27/18639	0.148148148148148	0.620942957799265	0.914925181746857	1
GO:0019199	transmembrane receptor protein kinase activity	14/4447	78/18639	0.179487179487179	0.752296275795264	0.916849811029249	1
GO:0005200	structural constituent of cytoskeleton	21/4447	112/18639	0.1875	0.785880930964695	0.919863592442868	1
GO:0042626	ATPase-coupled transmembrane transporter activity	18/4447	98/18639	0.183673469387755	0.769842544618477	0.922336911932094	1
GO:0030296	protein tyrosine kinase activator activity	5/4447	33/18639	0.151515151515152	0.635055297749249	0.922603838570898	1
GO:0015562	efflux transmembrane transporter activity	2/4447	16/18639	0.125	0.52392062064313	0.923339519843133	1
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	2/4447	16/18639	0.125	0.52392062064313	0.923339519843133	1
GO:0016722	oxidoreductase activity, acting on metal ions	2/4447	16/18639	0.125	0.52392062064313	0.923339519843133	1
GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	2/4447	16/18639	0.125	0.52392062064313	0.923339519843133	1
GO:0015377	chloride:monoatomic cation symporter activity	3/4447	22/18639	0.136363636363636	0.571549767974324	0.924083472177539	1
GO:0005004	GPI-linked ephrin receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0005008	hepatocyte growth factor receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0005009	insulin receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0005011	macrophage colony-stimulating factor receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0005018	platelet-derived growth factor alpha-receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0005020	stem cell factor receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0008288	boss receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0036332	placental growth factor receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0038062	protein tyrosine kinase collagen receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0060175	brain-derived neurotrophic factor receptor activity	8/4447	49/18639	0.163265306122449	0.684304484105313	0.925532589426619	1
GO:0042562	hormone binding	17/4447	94/18639	0.180851063829787	0.75801281284538	0.928516248990911	1
GO:0050698	proteoglycan sulfotransferase activity	4/4447	28/18639	0.142857142857143	0.598766423592149	0.928583049762434	1
GO:0004714	transmembrane receptor protein tyrosine kinase activity	10/4447	60/18639	0.166666666666667	0.698560827524174	0.933005649964029	1
GO:0008376	acetylgalactosaminyltransferase activity	5/4447	34/18639	0.147058823529412	0.616377200756624	0.934267555367662	1
GO:0051427	hormone receptor binding	5/4447	34/18639	0.147058823529412	0.616377200756624	0.934267555367662	1
GO:0004935	adrenergic receptor activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0004955	prostaglandin receptor activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0005031	tumor necrosis factor receptor activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0005345	purine nucleobase transmembrane transporter activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0008519	ammonium channel activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0015203	polyamine transmembrane transporter activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0015658	branched-chain amino acid transmembrane transporter activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0019911	structural constituent of myelin sheath	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0032052	bile acid binding	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0042166	acetylcholine binding	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0043121	neurotrophin binding	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0070097	delta-catenin binding	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0070739	protein-glutamic acid ligase activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0070740	tubulin-glutamic acid ligase activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0140940	histone H2A methyltransferase activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0140999	histone H3K4 trimethyltransferase activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:1990259	histone H2AQ104 methyltransferase activity	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:1990763	arrestin family protein binding	1/4447	10/18639	0.1	0.419136496514504	0.934554277704626	1
GO:0005006	epidermal growth factor receptor activity	8/4447	50/18639	0.16	0.670618394423207	0.935141910620107	1
GO:0005007	fibroblast growth factor receptor activity	8/4447	50/18639	0.16	0.670618394423207	0.935141910620107	1
GO:0005017	platelet-derived growth factor receptor activity	8/4447	50/18639	0.16	0.670618394423207	0.935141910620107	1
GO:0005019	platelet-derived growth factor beta-receptor activity	8/4447	50/18639	0.16	0.670618394423207	0.935141910620107	1
GO:0005212	structural constituent of eye lens	3/4447	23/18639	0.130434782608696	0.546699778062397	0.937534417897153	1
GO:0005283	amino acid:sodium symporter activity	3/4447	23/18639	0.130434782608696	0.546699778062397	0.937534417897153	1
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	2/4447	17/18639	0.117647058823529	0.493101760605299	0.938600478164991	1
GO:0045125	bioactive lipid receptor activity	2/4447	17/18639	0.117647058823529	0.493101760605299	0.938600478164991	1
GO:0003785	actin monomer binding	4/4447	29/18639	0.137931034482759	0.578119305537247	0.940228057281109	1
GO:0004629	phospholipase C activity	4/4447	29/18639	0.137931034482759	0.578119305537247	0.940228057281109	1
GO:0015026	coreceptor activity	10/4447	61/18639	0.163934426229508	0.687109010679515	0.941098612454438	1
GO:0005010	insulin-like growth factor receptor activity	8/4447	51/18639	0.156862745098039	0.657469014140399	0.943647309217167	1
GO:0005030	neurotrophin receptor activity	8/4447	51/18639	0.156862745098039	0.657469014140399	0.943647309217167	1
GO:0016597	amino acid binding	8/4447	51/18639	0.156862745098039	0.657469014140399	0.943647309217167	1
GO:0004623	phospholipase A2 activity	5/4447	35/18639	0.142857142857143	0.598766423592149	0.944330387068366	1
GO:0015295	solute:proton symporter activity	3/4447	24/18639	0.125	0.52392062064313	0.948749594967012	1
GO:0019838	growth factor binding	25/4447	136/18639	0.183823529411765	0.77047150094578	0.949174887269116	1
GO:0005217	intracellularly ligand-gated monoatomic ion channel activity	4/4447	30/18639	0.133333333333333	0.558848662019339	0.950115772372241	1
GO:0016769	transferase activity, transferring nitrogenous groups	4/4447	30/18639	0.133333333333333	0.558848662019339	0.950115772372241	1
GO:0022839	monoatomic ion-gated channel activity	4/4447	30/18639	0.133333333333333	0.558848662019339	0.950115772372241	1
GO:0000099	sulfur amino acid transmembrane transporter activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0001851	complement component C3b binding	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0004117	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0004523	RNA-DNA hybrid ribonuclease activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0004954	prostanoid receptor activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0008046	axon guidance receptor activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0008503	benzodiazepine receptor activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0015173	aromatic amino acid transmembrane transporter activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0015205	nucleobase transmembrane transporter activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0016594	glycine binding	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0042608	T cell receptor binding	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0048101	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0048407	platelet-derived growth factor binding	1/4447	11/18639	0.0909090909090909	0.381033178649549	0.950177076944925	1
GO:0004970	glutamate-gated receptor activity	2/4447	18/18639	0.111111111111111	0.465707218349449	0.950944843378827	1
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	2/4447	18/18639	0.111111111111111	0.465707218349449	0.950944843378827	1
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	8/4447	52/18639	0.153846153846154	0.644825379253083	0.951151523962555	1
GO:0004190	aspartic-type endopeptidase activity	5/4447	36/18639	0.138888888888889	0.582134022936811	0.952978967306205	1
GO:0004869	cysteine-type endopeptidase inhibitor activity	5/4447	36/18639	0.138888888888889	0.582134022936811	0.952978967306205	1
GO:0005504	fatty acid binding	7/4447	47/18639	0.148936170212766	0.624245845872666	0.953411391939727	1
GO:0003777	microtubule motor activity	11/4447	68/18639	0.161764705882353	0.678014920832286	0.953853235956263	1
GO:0008483	transaminase activity	3/4447	25/18639	0.12	0.502963795817405	0.958063507457349	1
GO:0015662	P-type ion transporter activity	3/4447	25/18639	0.12	0.502963795817405	0.958063507457349	1
GO:0140358	P-type transmembrane transporter activity	3/4447	25/18639	0.12	0.502963795817405	0.958063507457349	1
GO:0033293	monocarboxylic acid binding	13/4447	79/18639	0.164556962025316	0.689718285403614	0.958297993362013	1
GO:0022829	wide pore channel activity	5/4447	37/18639	0.135135135135135	0.566400670965546	0.960385386316126	1
GO:0043394	proteoglycan binding	5/4447	37/18639	0.135135135135135	0.566400670965546	0.960385386316126	1
GO:0070001	aspartic-type peptidase activity	5/4447	37/18639	0.135135135135135	0.566400670965546	0.960385386316126	1
GO:0005229	intracellularly calcium-gated chloride channel activity	2/4447	19/18639	0.105263157894737	0.441196312120531	0.960895300904277	1
GO:0141147	intracellularly calcium-gated channel activity	2/4447	19/18639	0.105263157894737	0.441196312120531	0.960895300904277	1
GO:0004126	cytidine deaminase activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0005247	voltage-gated chloride channel activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0008179	adenylate cyclase binding	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0008499	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0008504	monoamine transmembrane transporter activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0015132	prostaglandin transmembrane transporter activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0015166	polyol transmembrane transporter activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0016208	AMP binding	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0036009	protein-glutamine N-methyltransferase activity	1/4447	12/18639	0.0833333333333333	0.349280413762087	0.962071136362249	1
GO:0016247	channel regulator activity	31/4447	168/18639	0.18452380952381	0.773406630473192	0.962403800661392	1
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	8/4447	54/18639	0.148148148148148	0.620942957799265	0.963540763323575	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	23/4447	130/18639	0.176923076923077	0.741549186141046	0.964290972338522	1
GO:0008378	galactosyltransferase activity	4/4447	32/18639	0.125	0.52392062064313	0.965527595566222	1
GO:0042910	xenobiotic transmembrane transporter activity	4/4447	32/18639	0.125	0.52392062064313	0.965527595566222	1
GO:0004112	cyclic-nucleotide phosphodiesterase activity	3/4447	26/18639	0.115384615384615	0.483619034439813	0.965770314161283	1
GO:0004435	phosphatidylinositol phospholipase C activity	3/4447	26/18639	0.115384615384615	0.483619034439813	0.965770314161283	1
GO:0043548	phosphatidylinositol 3-kinase binding	3/4447	26/18639	0.115384615384615	0.483619034439813	0.965770314161283	1
GO:0019842	vitamin binding	27/4447	150/18639	0.18	0.754445693726107	0.966303375253988	1
GO:0099106	ion channel regulator activity	29/4447	160/18639	0.18125	0.759684899932539	0.967418448160752	1
GO:0141108	transporter regulator activity	31/4447	170/18639	0.182352941176471	0.764307728938213	0.968569758401688	1
GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	2/4447	20/18639	0.1	0.419136496514504	0.968891204272943	1
GO:0010851	cyclase regulator activity	2/4447	20/18639	0.1	0.419136496514504	0.968891204272943	1
GO:0004465	lipoprotein lipase activity	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0008417	fucosyltransferase activity	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0017154	semaphorin receptor activity	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0030955	potassium ion binding	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0071714	icosanoid transmembrane transporter activity	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0140410	monoatomic cation:bicarbonate symporter activity	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:1901338	catecholamine binding	1/4447	13/18639	0.0769230769230769	0.322412689626542	0.971126252945547	1
GO:0019956	chemokine binding	4/4447	33/18639	0.121212121212121	0.508044238199399	0.971448113772474	1
GO:0005126	cytokine receptor binding	53/4447	275/18639	0.192727272727273	0.807790338737044	0.971465625438791	1
GO:1901681	sulfur compound binding	53/4447	275/18639	0.192727272727273	0.807790338737044	0.971465625438791	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	5/4447	39/18639	0.128205128205128	0.537354482710903	0.972084338851848	1
GO:0005104	fibroblast growth factor receptor binding	3/4447	27/18639	0.111111111111111	0.465707218349449	0.972125955713087	1
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3/4447	27/18639	0.111111111111111	0.465707218349449	0.972125955713087	1
GO:0170055	lipid transmembrane transporter activity	8/4447	56/18639	0.142857142857143	0.598766423592149	0.973018030887291	1
GO:0042605	peptide antigen binding	6/4447	45/18639	0.133333333333333	0.558848662019339	0.973405809769157	1
GO:0016500	protein-hormone receptor activity	10/4447	67/18639	0.149253731343284	0.625576860469409	0.973944034392828	1
GO:0015179	L-amino acid transmembrane transporter activity	9/4447	62/18639	0.145161290322581	0.608423946553313	0.975258418944695	1
GO:0036122	BMP binding	2/4447	21/18639	0.0952380952380952	0.399177615728099	0.975298577293003	1
GO:0061891	calcium ion sensor activity	2/4447	21/18639	0.0952380952380952	0.399177615728099	0.975298577293003	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4/4447	34/18639	0.117647058823529	0.493101760605299	0.976405521559782	1
GO:0004065	arylsulfatase activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0005161	platelet-derived growth factor receptor binding	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0005344	oxygen carrier activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0008195	phosphatidate phosphatase activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0008494	translation activator activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0015926	glucosidase activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0019763	immunoglobulin receptor activity	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:0043176	amine binding	1/4447	14/18639	0.0714285714285714	0.299383211796074	0.978019925937663	1
GO:1901682	sulfur compound transmembrane transporter activity	9/4447	63/18639	0.142857142857143	0.598766423592149	0.97867494688775	1
GO:0008194	UDP-glycosyltransferase activity	25/4447	145/18639	0.172413793103448	0.722649131921559	0.978970895180479	1
GO:0016881	acid-amino acid ligase activity	2/4447	22/18639	0.0909090909090909	0.381033178649549	0.980420087804549	1
GO:0140784	metal ion sensor activity	2/4447	22/18639	0.0909090909090909	0.381033178649549	0.980420087804549	1
GO:0042287	MHC protein binding	5/4447	41/18639	0.121951219512195	0.511142068920127	0.980503284948442	1
GO:0005416	amino acid:monoatomic cation symporter activity	3/4447	29/18639	0.103448275862069	0.433589479152935	0.981634532944017	1
GO:0035250	UDP-galactosyltransferase activity	3/4447	29/18639	0.103448275862069	0.433589479152935	0.981634532944017	1
GO:0051861	glycolipid binding	3/4447	29/18639	0.103448275862069	0.433589479152935	0.981634532944017	1
GO:0017046	peptide hormone binding	7/4447	53/18639	0.132075471698113	0.553576504830477	0.981983653406426	1
GO:0015085	calcium ion transmembrane transporter activity	25/4447	147/18639	0.170068027210884	0.712817170943034	0.982936804824453	1
GO:0015459	potassium channel regulator activity	8/4447	59/18639	0.135593220338983	0.568320673240006	0.983074911845128	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	10/4447	70/18639	0.142857142857143	0.598766423592149	0.983105796063754	1
GO:0004089	carbonate dehydratase activity	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0004953	icosanoid receptor activity	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0010181	FMN binding	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0015250	water channel activity	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0015556	C4-dicarboxylate transmembrane transporter activity	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0047372	monoacylglycerol lipase activity	1/4447	15/18639	0.0666666666666667	0.279424331009669	0.983268000533916	1
GO:0008307	structural constituent of muscle	5/4447	42/18639	0.119047619047619	0.498972019660124	0.983757016675343	1
GO:0042056	chemoattractant activity	5/4447	42/18639	0.119047619047619	0.498972019660124	0.983757016675343	1
GO:0004022	alcohol dehydrogenase (NAD+) activity	2/4447	23/18639	0.0869565217391304	0.364466518708264	0.984504437319539	1
GO:0016849	phosphorus-oxygen lyase activity	2/4447	23/18639	0.0869565217391304	0.364466518708264	0.984504437319539	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	2/4447	23/18639	0.0869565217391304	0.364466518708264	0.984504437319539	1
GO:0001965	G-protein alpha-subunit binding	3/4447	30/18639	0.1	0.419136496514504	0.985136617451992	1
GO:0001968	fibronectin binding	3/4447	30/18639	0.1	0.419136496514504	0.985136617451992	1
GO:0098918	structural constituent of synapse	3/4447	30/18639	0.1	0.419136496514504	0.985136617451992	1
GO:0008237	metallopeptidase activity	32/4447	184/18639	0.173913043478261	0.728933037416529	0.986780069772299	1
GO:0023023	MHC protein complex binding	4/4447	37/18639	0.108108108108108	0.453120536772437	0.986851062986117	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	1/4447	16/18639	0.0625	0.261960310321565	0.987263232579968	1
GO:0015378	sodium:chloride symporter activity	1/4447	16/18639	0.0625	0.261960310321565	0.987263232579968	1
GO:0022841	potassium ion leak channel activity	1/4447	16/18639	0.0625	0.261960310321565	0.987263232579968	1
GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	1/4447	16/18639	0.0625	0.261960310321565	0.987263232579968	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	2/4447	24/18639	0.0833333333333333	0.349280413762087	0.987754877533405	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	2/4447	24/18639	0.0833333333333333	0.349280413762087	0.987754877533405	1
GO:0019957	C-C chemokine binding	2/4447	24/18639	0.0833333333333333	0.349280413762087	0.987754877533405	1
GO:0005310	dicarboxylic acid transmembrane transporter activity	3/4447	31/18639	0.0967741935483871	0.405615964368875	0.987992783077811	1
GO:0005262	calcium channel activity	21/4447	131/18639	0.16030534351145	0.671898200519434	0.989207140262979	1
GO:0031406	carboxylic acid binding	32/4447	187/18639	0.171122994652406	0.717238924516799	0.990203518590743	1
GO:0008484	sulfuric ester hydrolase activity	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0008569	minus-end-directed microtubule motor activity	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0015347	sodium-independent organic anion transmembrane transporter activity	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0030548	acetylcholine receptor regulator activity	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0045236	CXCR chemokine receptor binding	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0070492	oligosaccharide binding	1/4447	17/18639	0.0588235294117647	0.24655088030265	0.990304654730904	1
GO:0015106	bicarbonate transmembrane transporter activity	3/4447	32/18639	0.09375	0.392940465482348	0.990316767992803	1
GO:0043177	organic acid binding	32/4447	189/18639	0.169312169312169	0.709649094627732	0.992014546843863	1
GO:0008066	glutamate receptor activity	2/4447	26/18639	0.0769230769230769	0.322412689626542	0.992383937604189	1
GO:0030247	polysaccharide binding	2/4447	26/18639	0.0769230769230769	0.322412689626542	0.992383937604189	1
GO:0005372	water transmembrane transporter activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0015280	ligand-gated sodium channel activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0015373	monoatomic anion:sodium symporter activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0022851	GABA-gated chloride ion channel activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0032393	MHC class I receptor activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0099602	neurotransmitter receptor regulator activity	1/4447	18/18639	0.0555555555555556	0.232853609174725	0.992619937751615	1
GO:0022804	active transmembrane transporter activity	88/4447	457/18639	0.192560175054705	0.807089971406485	0.992690758276179	1
GO:0090482	vitamin transmembrane transporter activity	3/4447	34/18639	0.0882352941176471	0.369826320453974	0.993732482949196	1
GO:0015252	proton channel activity	2/4447	27/18639	0.0740740740740741	0.310471478899633	0.994004576155477	1
GO:0004890	GABA-A receptor activity	1/4447	19/18639	0.0526315789473684	0.220598156060265	0.994382417576467	1
GO:0008574	plus-end-directed microtubule motor activity	1/4447	19/18639	0.0526315789473684	0.220598156060265	0.994382417576467	1
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	1/4447	19/18639	0.0526315789473684	0.220598156060265	0.994382417576467	1
GO:0034987	immunoglobulin receptor binding	1/4447	19/18639	0.0526315789473684	0.220598156060265	0.994382417576467	1
GO:0005518	collagen binding	9/4447	72/18639	0.125	0.52392062064313	0.994817561260927	1
GO:0005343	organic acid:sodium symporter activity	3/4447	35/18639	0.0857142857142857	0.359259854155289	0.994968879920283	1
GO:0005242	inward rectifier potassium channel activity	2/4447	28/18639	0.0714285714285714	0.299383211796074	0.99528561244227	1
GO:0005326	neurotransmitter transmembrane transporter activity	1/4447	20/18639	0.05	0.209568248257252	0.995724060381915	1
GO:0030627	pre-mRNA 5'-splice site binding	1/4447	20/18639	0.05	0.209568248257252	0.995724060381915	1
GO:0015171	amino acid transmembrane transporter activity	14/4447	102/18639	0.137254901960784	0.575285387372849	0.99617437510516	1
GO:0043236	laminin binding	2/4447	29/18639	0.0689655172413793	0.289059652768624	0.996296803516215	1
GO:0005253	monoatomic anion channel activity	14/4447	103/18639	0.135922330097087	0.569700092349812	0.996694232253054	1
GO:0015125	bile acid transmembrane transporter activity	1/4447	21/18639	0.0476190476190476	0.19958880786405	0.996745334536361	1
GO:0030020	extracellular matrix structural constituent conferring tensile strength	4/4447	44/18639	0.0909090909090909	0.381033178649549	0.996840372069672	1
GO:0004620	phospholipase activity	15/4447	109/18639	0.137614678899083	0.576793343827299	0.996929000881557	1
GO:0048019	receptor antagonist activity	2/4447	30/18639	0.0666666666666667	0.279424331009669	0.997093959663659	1
GO:0004222	metalloendopeptidase activity	15/4447	110/18639	0.136363636363636	0.571549767974324	0.997342461675346	1
GO:0005501	retinoid binding	3/4447	38/18639	0.0789473684210526	0.330897234090398	0.997418482353857	1
GO:0019840	isoprenoid binding	3/4447	38/18639	0.0789473684210526	0.330897234090398	0.997418482353857	1
GO:0005243	gap junction channel activity	1/4447	22/18639	0.0454545454545455	0.190516589324775	0.997522727237876	1
GO:0016493	C-C chemokine receptor activity	1/4447	23/18639	0.0434782608695652	0.182233259354132	0.998114467688709	1
GO:0016917	GABA receptor activity	1/4447	23/18639	0.0434782608695652	0.182233259354132	0.998114467688709	1
GO:0099186	structural constituent of postsynapse	1/4447	23/18639	0.0434782608695652	0.182233259354132	0.998114467688709	1
GO:0005178	integrin binding	24/4447	161/18639	0.149068322981366	0.624799746357025	0.998157348881964	1
GO:0015144	carbohydrate transmembrane transporter activity	3/4447	40/18639	0.075	0.314352372385878	0.998355484519445	1
GO:0050840	extracellular matrix binding	7/4447	67/18639	0.104477611940299	0.437903802328586	0.998468543979307	1
GO:0004806	triacylglycerol lipase activity	1/4447	24/18639	0.0416666666666667	0.174640206881043	0.998564884651983	1
GO:0061134	peptidase regulator activity	36/4447	226/18639	0.15929203539823	0.667651056394785	0.998707047469506	1
GO:0015291	secondary active transmembrane transporter activity	48/4447	287/18639	0.167247386759582	0.700994837376174	0.998794611135184	1
GO:0008081	phosphoric diester hydrolase activity	10/4447	87/18639	0.114942528735632	0.481766087947706	0.998882442003396	1
GO:0008509	monoatomic anion transmembrane transporter activity	21/4447	149/18639	0.140939597315436	0.59072929038957	0.998908312611596	1
GO:0001637	G protein-coupled chemoattractant receptor activity	1/4447	26/18639	0.0384615384615385	0.161206344813271	0.999168675650776	1
GO:0004950	chemokine receptor activity	1/4447	26/18639	0.0384615384615385	0.161206344813271	0.999168675650776	1
GO:0019865	immunoglobulin binding	1/4447	26/18639	0.0384615384615385	0.161206344813271	0.999168675650776	1
GO:0004175	endopeptidase activity	71/4447	405/18639	0.175308641975309	0.734782500062464	0.999256528104041	1
GO:0005272	sodium channel activity	4/4447	51/18639	0.0784313725490196	0.328734507070199	0.999290454056499	1
GO:0030547	signaling receptor inhibitor activity	3/4447	44/18639	0.0681818181818182	0.285774883987162	0.999341078458561	1
GO:0008395	steroid hydroxylase activity	1/4447	27/18639	0.037037037037037	0.155235739449816	0.999367294862133	1
GO:0008009	chemokine activity	3/4447	45/18639	0.0666666666666667	0.279424331009669	0.999477011682198	1
GO:0030246	carbohydrate binding	45/4447	280/18639	0.160714285714286	0.673612226541167	0.999482924601442	1
GO:0051119	sugar transmembrane transporter activity	1/4447	28/18639	0.0357142857142857	0.149691605898037	0.999518468285091	1
GO:0046943	carboxylic acid transmembrane transporter activity	27/4447	188/18639	0.143617021276596	0.601951351377213	0.999558945840868	1
GO:0005342	organic acid transmembrane transporter activity	27/4447	189/18639	0.142857142857143	0.598766423592149	0.999613230300767	1
GO:0015101	organic cation transmembrane transporter activity	8/4447	81/18639	0.0987654320987654	0.413961971866177	0.999638375541051	1
GO:0046906	tetrapyrrole binding	20/4447	152/18639	0.131578947368421	0.551495390150663	0.999670377576674	1
GO:0099095	ligand-gated monoatomic anion channel activity	3/4447	47/18639	0.0638297872340425	0.267533933945428	0.999671394096921	1
GO:0008514	organic anion transmembrane transporter activity	42/4447	269/18639	0.156133828996283	0.654413860728966	0.999679607926911	1
GO:0016298	lipase activity	16/4447	130/18639	0.123076923076923	0.515860303402467	0.99969812258913	1
GO:0020037	heme binding	18/4447	142/18639	0.126760563380282	0.53129978431416	0.999725094854125	1
GO:0071855	neuropeptide receptor binding	2/4447	40/18639	0.05	0.209568248257252	0.99975358735815	1
GO:0005184	neuropeptide hormone activity	1/4447	31/18639	0.032258064516129	0.135205321456292	0.99978774812213	1
GO:0048020	CCR chemokine receptor binding	3/4447	50/18639	0.06	0.251481897908702	0.999837321630652	1
GO:0160041	neuropeptide activity	1/4447	32/18639	0.03125	0.130980155160783	0.999838472762117	1
GO:0015293	symporter activity	18/4447	146/18639	0.123287671232877	0.5167436258398	0.99985129738507	1
GO:0005245	voltage-gated calcium channel activity	2/4447	43/18639	0.0465116279069767	0.194947207681165	0.999883886968264	1
GO:0005539	glycosaminoglycan binding	35/4447	242/18639	0.144628099173554	0.606189147851556	0.999898735817961	1
GO:0015020	glucuronosyltransferase activity	1/4447	34/18639	0.0294117647058824	0.123275440151325	0.999906456798915	1
GO:0019825	oxygen binding	1/4447	34/18639	0.0294117647058824	0.123275440151325	0.999906456798915	1
GO:0008201	heparin binding	22/4447	172/18639	0.127906976744186	0.536104821123203	0.999910081369524	1
GO:0015294	solute:monoatomic cation symporter activity	12/4447	116/18639	0.103448275862069	0.433589479152935	0.99994150463619	1
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2/4447	46/18639	0.0434782608695652	0.182233259354132	0.999945525005814	1
GO:0015370	solute:sodium symporter activity	6/4447	79/18639	0.0759493670886076	0.31833151634013	0.999963118810571	1
GO:0042379	chemokine receptor binding	5/4447	72/18639	0.0694444444444444	0.291067011468406	0.999964864651033	1
GO:0008083	growth factor activity	19/4447	162/18639	0.117283950617284	0.491579841591085	0.99997041355686	1
GO:0015081	sodium ion transmembrane transporter activity	19/4447	164/18639	0.115853658536585	0.485584965474121	0.999978574841459	1
GO:0004896	cytokine receptor activity	8/4447	96/18639	0.0833333333333333	0.349280413762087	0.999980713721828	1
GO:0003730	mRNA 3'-UTR binding	36/4447	262/18639	0.137404580152672	0.575912743302372	0.999985219891519	1
GO:0008227	G protein-coupled amine receptor activity	1/4447	41/18639	0.024390243902439	0.102228413784025	0.999986181406214	1
GO:0001664	G protein-coupled receptor binding	42/4447	297/18639	0.141414141414141	0.592718277899299	0.999989590949409	1
GO:0004497	monooxygenase activity	9/4447	106/18639	0.0849056603773585	0.355870610248164	0.999989921563363	1
GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	2/4447	53/18639	0.0377358490566038	0.158164715665851	0.999990816106126	1
GO:0022824	transmitter-gated monoatomic ion channel activity	3/4447	63/18639	0.0476190476190476	0.19958880786405	0.999992777755573	1
GO:0022835	transmitter-gated channel activity	3/4447	63/18639	0.0476190476190476	0.19958880786405	0.999992777755573	1
GO:0015108	chloride transmembrane transporter activity	11/4447	121/18639	0.0909090909090909	0.381033178649549	0.999992846895531	1
GO:0015103	inorganic anion transmembrane transporter activity	18/4447	165/18639	0.109090909090909	0.457239814379459	0.999993221272563	1
GO:0004867	serine-type endopeptidase inhibitor activity	7/4447	95/18639	0.0736842105263158	0.308837418484371	0.999994373398576	1
GO:0061135	endopeptidase regulator activity	21/4447	184/18639	0.114130434782609	0.478362305804597	0.999994374509482	1
GO:0004866	endopeptidase inhibitor activity	17/4447	161/18639	0.105590062111801	0.442566487002893	0.999995238738442	1
GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	2/4447	56/18639	0.0357142857142857	0.149691605898037	0.999995740254561	1
GO:0030414	peptidase inhibitor activity	18/4447	169/18639	0.106508875739645	0.446417570252135	0.999996572994482	1
GO:0005254	chloride channel activity	5/4447	83/18639	0.0602409638554217	0.252491865370183	0.999996988686785	1
GO:0017171	serine hydrolase activity	22/4447	198/18639	0.111111111111111	0.465707218349449	0.999998506455302	1
GO:0008236	serine-type peptidase activity	21/4447	194/18639	0.108247422680412	0.453704454989927	0.999998930475928	1
GO:0005230	extracellular ligand-gated monoatomic ion channel activity	3/4447	73/18639	0.0410958904109589	0.172247875279933	0.999999378706118	1
GO:0005201	extracellular matrix structural constituent	16/4447	168/18639	0.0952380952380952	0.399177615728099	0.999999552144047	1
GO:0004252	serine-type endopeptidase activity	17/4447	176/18639	0.0965909090909091	0.404847752315146	0.999999668928559	1
GO:0015079	potassium ion transmembrane transporter activity	14/4447	160/18639	0.0875	0.366744434450191	0.999999823712364	1
GO:0098960	postsynaptic neurotransmitter receptor activity	2/4447	69/18639	0.0289855072463768	0.121488839569421	0.999999851688675	1
GO:0099094	ligand-gated monoatomic cation channel activity	10/4447	136/18639	0.0735294117647059	0.308188600378312	0.999999908748748	1
GO:0001653	peptide receptor activity	8/4447	128/18639	0.0625	0.261960310321565	0.999999977902603	1
GO:0046873	metal ion transmembrane transporter activity	60/4447	450/18639	0.133333333333333	0.558848662019339	0.999999993879661	1
GO:0008528	G protein-coupled peptide receptor activity	6/4447	122/18639	0.0491803278688525	0.206132703203855	0.999999997611148	1
GO:0030594	neurotransmitter receptor activity	3/4447	97/18639	0.0309278350515464	0.129629844282836	0.999999998494807	1
GO:0140375	immune receptor activity	10/4447	156/18639	0.0641025641025641	0.268677241355451	0.999999998703085	1
GO:0005267	potassium channel activity	5/4447	124/18639	0.0403225806451613	0.169006651820365	0.999999999808425	1
GO:0005244	voltage-gated monoatomic ion channel activity	11/4447	173/18639	0.0635838150289017	0.266502974662401	0.999999999836105	1
GO:0022832	voltage-gated channel activity	11/4447	175/18639	0.0628571428571429	0.263457226380546	0.999999999893846	1
GO:0005261	monoatomic cation channel activity	36/4447	341/18639	0.105571847507331	0.442490142947864	0.999999999921965	1
GO:0005249	voltage-gated potassium channel activity	2/4447	98/18639	0.0204081632653061	0.0855380605131641	0.999999999926198	1
GO:0005125	cytokine activity	19/4447	234/18639	0.0811965811965812	0.340324505716905	0.999999999934935	1
GO:0015276	ligand-gated monoatomic ion channel activity	11/4447	186/18639	0.0591397849462366	0.247876422669868	0.999999999990491	1
GO:0022834	ligand-gated channel activity	11/4447	188/18639	0.0585106382978723	0.245239439449976	0.999999999993893	1
GO:0003823	antigen binding	9/4447	174/18639	0.0517241379310345	0.216794739576468	0.999999999995869	1
GO:0022843	voltage-gated monoatomic cation channel activity	5/4447	143/18639	0.034965034965035	0.146551222557519	0.999999999998177	1
GO:0005216	monoatomic ion channel activity	48/4447	448/18639	0.107142857142857	0.449074817694112	0.999999999999774	1
GO:0005179	hormone activity	2/4447	132/18639	0.0151515151515152	0.0635055297749249	0.999999999999991	1
GO:0022836	gated channel activity	21/4447	318/18639	0.0660377358490566	0.276788252415239	1	1
GO:0030371	translation repressor activity	13/4447	329/18639	0.0395136778115502	0.16561624482336	1	1
GO:0045182	translation regulator activity	16/4447	356/18639	0.0449438202247191	0.188375953489665	1	1