category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	63/867	308/9376	2.21201635734508	MT-CO2/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/AP2B1/MT-CO3/ATP5F1E/PSMA7/POLR2I/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/PSMC1/PSMC3/POLR2L/COX4I1/MT-ND6/MT-ND4L/AP2S1/UQCRQ/NDUFB1/NDUFB10/GPX7/RCOR1/NDUFA1/TUBA4A/UQCRB/GPX3/HIP1/CREB3L1/NDUFS7/CLTB/AMBRA1/NDUFS6/ULK1/UQCR10/NDUFS8/DCTN4/SP1/MAP2K7/PSMD3/TUBB4B/POLR2G/DNAL1/NDUFB2/HDAC2/SLC25A4/DNALI1/ITPR1/ADRM1/UQCRC1/NDUFB11/KLC1/ATG13/TUBA3E/AP2A2/NDUFA13/PSMD1	6.90373334845103
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	52/867	238/9376	2.36278871410156	RPL13A/RPS26/RPS28/RPS27/C1QB/RPL37A/RPL36/RPS8/RPS20/C1QA/RPL10/RPS11/RPL28/RPL31/RPS15/RPL18A/RPS17/PLCG2/RPL27A/RPL7/RPL23/RPL8/RPS14/RPL35/RPS29/RPLP2/RPL11/VWF/C1QC/CYBB/RPLP0/RPL21/RPS5/EGFR/PIK3R1/RPL41/RPS9/C5AR1/UBA52/RPS2/OAS3/IL1B/RPS16/IKBKB/F13A1/FCGR2A/RPL13/FGA/TRAF3/RELA/TYK2/NFKBIB	6.79747086937641
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/867	205/9376	2.42662390637747	MT-CO2/MT-ND3/COX7A1/MT-ND1/CTSD/GAPDH/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/TGFBR1/ATP5F1E/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/CYBA/CYBB/COX4I1/MT-ND6/TGFB1/MT-ND4L/PIK3R1/RAC1/UQCRQ/NDUFB1/NDUFB10/NDUFA1/UQCRB/NDUFS7/NCF1/NDUFS6/UQCR10/NDUFS8/SLC2A1/SP1/RELA/NDUFB2/SLC25A4/PARP1/UQCRC1/NDUFB11/CPT2/PPARA/NDUFA13	6.59225512112747
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	56/867	275/9376	2.20218517353465	MT-CO2/MT-ND3/C1QB/COX7A1/C1QA/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/CCL5/ATP5F1E/PSMA7/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/CYBA/PSMC1/PSMC3/C1QC/CYBB/COX4I1/MT-ND6/MT-ND4L/PIK3R1/RAC1/UQCRQ/NDUFB1/NDUFB10/PPP3CA/NDUFA1/TUBA4A/UQCRB/CREB3L1/IL1B/NDUFS7/ATF4/NCF1/NDUFS6/UQCR10/NDUFS8/PRKACB/PSMD3/TUBB4B/NDUFB2/SLC25A4/ITPR1/ADRM1/UQCRC1/NDUFB11/KLC1/TUBA3E/NDUFA13/PSMD1	6.45875903953931
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/867	155/9376	2.58147858763999	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/DYNC1I2/HLA-DPA1/CD14/CYBA/HLA-G/HLA-DQA1/HLA-DPB1/CYBB/HLA-DMB/CTSL/ITGB2/RAC1/FCGR3A/HLA-DMA/TCIRG1/MRC2/TUBA4A/HLA-C/MSR1/MRC1/NCF1/RAB5B/FCGR2A/HLA-DOA/TUBB4B/SEC61A2/ITGAM/FCGR2B/TUBA3E/OLR1/ATP6V1E1/HLA-DQB1	6.33718053186735
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	27/867	100/9376	2.9198615916955	HLA-DRA/HLA-DRB1/HLA-DRB5/CD59/HLA-DPA1/IL1R2/CD14/HLA-DQA1/HLA-DPB1/CSF1R/HLA-DMB/CD34/IL7R/HLA-DMA/IL1B/CD3D/CD3E/CD3G/CD2/HLA-DOA/CD37/CSF2RA/FLT3LG/CD9/ITGAM/CD7/HLA-DQB1	6.16091866573407
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/867	227/9376	2.19144449694882	MT-CO2/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/GSTA1/ATP5F1E/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/CYBA/COX4I1/MT-ND6/VEGFA/MT-ND4L/EGFR/PIK3R1/RAC1/HMOX1/UQCRQ/NDUFB1/NDUFB10/NFE2L2/NDUFA1/UQCRB/NDUFS7/NCF1/AKR1A1/NDUFS6/IKBKB/UQCR10/NDUFS8/MAP2K7/SLC26A2/HRAS/RELA/NDUFB2/SLC25A4/UQCRC1/NDUFB11/NDUFA13	5.80037210921343
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/867	138/9376	2.5860287849155	MT-CO2/ATP5ME/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/COX4I1/MT-ND6/MT-ND4L/UQCRQ/NDUFB1/NDUFB10/NDUFA1/TCIRG1/UQCRB/NDUFS7/NDUFS6/UQCR10/NDUFS8/NDUFB2/UQCRC1/NDUFB11/ATP6V1E1/NDUFA13	5.99125155115661
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	23/867	78/9376	3.18883269748322	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CYBA/HLA-DQA1/HLA-DPB1/CYBB/TGFB1/HLA-DMB/ITGB2/FCGR3A/HLA-DMA/IL1B/NCF1/FCGR2A/RELA/HLA-DOA/PTPN6/NFKBIB/ITGAM/JAK2/HLA-DQB1	6.19613716501815
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	64/867	368/9376	1.88074820721127	MT-CO2/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/PSMA7/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/PSMC1/PSMC3/MAP1LC3A/COX4I1/TNFRSF1B/MT-ND6/MT-ND4L/RAC1/UQCRQ/NDUFB1/NDUFB10/CHCHD10/GPX7/PPP3CA/NDUFA1/POM121C/TUBA4A/UQCRB/GPX3/ANXA11/NDUFS7/AMBRA1/ATF4/CCS/TARDBP/NDUFS6/NUP214/ULK1/UQCR10/NDUFS8/DCTN4/PSMD3/FIG4/TUBB4B/DNAL1/NDUFB2/VAPB/NUP93/NUP88/DNALI1/ADRM1/UQCRC1/POM121/NDUFB11/KLC1/ATG13/TUBA3E/NDUFA13/PSMD1	5.50195980797732
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/867	39/9376	4.15934699671724	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-C/HLA-DOA/CD86/HLA-DQB1	6.31076309418662
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/867	44/9376	3.93247352416903	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA/IL1B/HLA-C/HLA-DOA/CD86/HLA-DQB1	6.22341837872751
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	50/867	268/9376	2.01759369243747	MT-CO2/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/PSMA7/MT-ND5/MAOA/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/PSMC1/PSMC3/COX4I1/MT-ND6/MT-ND4L/UQCRQ/NDUFB1/NDUFB10/NFE2L2/UBA1/NDUFA1/UBA52/TUBA4A/UQCRB/NDUFS7/TRAP1/ATF4/NDUFS6/UQCR10/NDUFS8/PRKACB/LRRK2/PSMD3/TUBB4B/NDUFB2/SLC25A4/ITPR1/ADRM1/UQCRC1/NDUFB11/KLC1/TUBA3E/NDUFA13/PSMD1	5.39493501196976
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/867	45/9376	3.84508522363194	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA/IL1B/HLA-C/HLA-DOA/CD86/HLA-DQB1	6.10651414411138
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	41/867	205/9376	2.16286043829296	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/NCOR2/PLCG2/TAPBP/HLA-G/HLA-DQA1/PSMC1/HLA-DPB1/PSMC3/LYN/HLA-DMB/PIK3R1/RAC1/HLA-DMA/RUNX3/OAS3/CD3D/HLA-C/CDKN1A/CD3E/IKBKB/CD3G/ITGAL/MAP2K7/RBPJ/PSMD3/TRAF3/RELA/TYK2/HLA-DOA/CCND1/NFKBIB/HDAC2/ADRM1/HLA-DQB1/PSMD1	5.37343629615653
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	76/867	480/9376	1.7122645136486	MT-CO2/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/PSMA7/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/PSMC1/PSMC3/MAP1LC3A/CYBB/COX4I1/TNFRSF1B/MT-ND6/MT-ND4L/ATXN3/RAC1/UQCRQ/NDUFB1/NDUFB10/UBA1/GPX7/PPP3CA/WNT10B/NDUFA1/UBA52/TUBA4A/UQCRB/GPX3/HIP1/IL1B/WNT3/NDUFS7/TRAP1/AMBRA1/CDK5/ATF4/CCS/TARDBP/NDUFS6/APC/ULK1/UQCR10/NDUFS8/WNT5B/DCTN4/MAP2K7/LRRK2/HRAS/PSMD3/RELA/FIG4/TUBB4B/DNAL1/NDUFB2/VAPB/SLC25A4/DNALI1/ITPR1/ADRM1/UQCRC1/NDUFB11/ZFYVE1/KLC1/ATG13/TUBA3E/NDUFA13/PSMD1	5.11352594953371
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/867	224/9376	2.07595979568298	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFBR1/IL1R2/HLA-G/HLA-DQA1/TLN1/HLA-DPB1/TGFB1/HLA-DMB/RANBP3/ITGB2/PIK3R1/SPI1/PPP3CA/FDPS/HLA-DMA/CREB3L1/CD3D/IL2RG/HLA-C/DLG1/CDKN1A/CD3E/ATF4/IKBKB/CD3G/ITGAL/PRKACB/SLC2A1/CDKN2C/HRAS/RELA/HLA-DOA/CCND1/SLC25A4/ANAPC11/CRTC1/HLA-DQB1	5.20257047953306
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	20/867	70/9376	3.08980062613281	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/ITGB2/RAC1/HLA-DMA/HLA-C/ITGAL/DTNA/HLA-DOA/CCND1/CD86/HLA-DQB1	5.60180872914228
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	24/867	95/9376	2.73203423784374	HLA-DRA/FLT1/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL5/ACP5/HLA-DQA1/CCL3/HLA-DPB1/VEGFA/TGFB1/HLA-DMB/CTSL/ITGB2/LTB/HLA-DMA/TCIRG1/IL1B/ITGAL/HLA-DOA/CD86/ATP6V1E1/HLA-DQB1	5.41597703366549
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/867	109/9376	2.57955832089987	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFBR1/HLA-DQA1/HLA-DPB1/TGFB1/HLA-DMB/GATA3/PPP3CA/EBI3/HLA-DMA/IL1B/CD3D/IL2RG/CD3E/IKBKB/CD3G/RELA/TYK2/HLA-DOA/NFKBIB/RXRB/JAK2/HLA-DQB1	5.29462563755412
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	63/867	388/9376	1.7559305104698	MT-CO2/MT-ND3/COX7A1/MT-ND1/GAPDH/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/PSMA7/MT-ND5/MT-ND4/ATP5F1D/IRS2/MT-ATP8/NDUFA3/PSMC1/PSMC3/CYBB/COX4I1/APOE/MT-ND6/MT-ND4L/PIK3R1/UQCRQ/NDUFB1/NDUFB10/PPP3CA/WNT10B/NDUFA1/TUBA4A/UQCRB/IL1B/WNT3/NDUFS7/AMBRA1/CDK5/ATF4/APH1A/NDUFS6/IKBKB/APC/ULK1/UQCR10/NDUFS8/WNT5B/MAP2K7/HRAS/PSMD3/RELA/TUBB4B/NDUFB2/SLC25A4/ITPR1/ADRM1/UQCRC1/NDUFB11/KLC1/ATG13/TUBA3E/NDUFA13/PSMD1	4.85424990173129
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/867	99/9376	2.62164901611268	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DRB5/HLA-DPA1/KRT18/HLA-DQA1/KRT19/HLA-DPB1/C1QC/HLA-DMB/ITGB2/FCGR3A/HLA-DMA/C5AR1/ITGAL/FCGR2A/HLA-DOA/FPR3/PTAFR/ITGAM/FCGR2B/HLA-DQB1	5.17757748467625
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/867	93/9376	2.67450484305044	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/HLA-DPB1/HLA-DMB/GATA3/PPP3CA/HLA-DMA/RUNX3/CD3D/IL2RG/CD3E/IKBKB/CD3G/RBPJ/RELA/TYK2/HLA-DOA/NFKBIB/JAK2/HLA-DQB1	5.18011775296763
Human Diseases	Immune disease	hsa05310	Asthma	12/867	32/9376	4.05536332179931	HLA-DRA/PRG2/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/FCER1G/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-DOA/HLA-DQB1	5.52620969214298
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	42/867	235/9376	1.93276890230435	MT-CO2/ATP5ME/MT-ND3/COX7A1/MT-ND1/MT-ND2/MT-CYB/MT-ATP6/MT-CO3/ATP5F1E/BMP8B/MT-ND5/MT-ND4/ATP5F1D/MT-ATP8/NDUFA3/PNPLA2/COX4I1/MT-ND6/MT-ND4L/UQCRQ/NDUFB1/NDUFB10/NDUFA1/UQCRB/CREB3L1/NDUFS7/NDUFS6/RPS6KA2/UQCR10/NDUFS8/PRKACB/HRAS/SMARCD2/NDUFAF2/CPT1A/NDUFB2/UQCRC1/NDUFB11/CPT2/ARID1A/NDUFA13	4.62239506073058
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	29/867	142/9376	2.20855467290479	TYROBP/TGFBR1/TNFRSF11B/PLCG2/CYBA/ACP5/TGFB1/CSF1R/PIK3R1/SPI1/RAC1/FCGR3A/PPP3CA/IL1B/NCF1/IKBKB/LILRB4/LILRB5/MAP2K7/FOSL2/FCGR2A/RELA/TYK2/LILRB2/ITPR1/LILRB3/FCGR2B/LILRB1/TREM2	4.63203107304806
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	43/867	250/9376	1.86005997693195	PSAP/CTSD/CD68/AP2B1/CTSZ/TPP1/LAPTM5/ACP5/CTSA/VAMP8/CTSL/AP2S1/GGA1/CLN8/TCIRG1/OSBPL5/GALNS/VPS11/CLTB/AP5Z1/LAMTOR4/NPC2/SUMF1/VPS33A/TFE3/SLC29A1/GGA2/AP1S2/FIG4/HEXB/BLOC1S1/AGA/CTSF/PLA2G15/CTSO/PLEKHM1/CTSH/MCOLN1/NAGA/HGSNAT/ATP6V1E1/AP2A2/SLC11A1	4.39961258209799
Genetic Information Processing	Translation	hsa03010	Ribosome	39/867	222/9376	1.89980984444652	RPL13A/RPS26/RPS28/RPS27/RPL37A/RPL36/RPS8/RPS20/RPL10/RPS11/RPL28/RPL31/RPS15/RPL18A/RPS17/RPL27A/RPL7/MRPS18A/RPL23/RPL8/RPS14/RPL35/RPS29/RPLP2/RPL11/MRPS6/RPLP0/RPL21/RPS5/RPL41/RPS9/UBA52/RPS2/MRPL48/RPS16/RPL13/MRPS5/MRPL33/MRPL1	4.3308954381541
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	15/867	54/9376	3.00397283096245	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-C/HLA-DOA/CD86/HLA-DQB1	4.71400550083298
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/867	157/9376	2.0664271703436	MT-CO2/COX7A1/MT-CYB/MT-CO3/IRS2/NDUFA3/COX4I1/TGFB1/PIK3R1/RAC1/UQCRQ/NDUFB1/NDUFB10/NDUFA1/UQCRB/IL1B/NDUFS7/ATF4/NDUFS6/IKBKB/UQCR10/NDUFS8/ADIPOR2/GSK3A/RELA/NDUFB2/UQCRC1/NDUFB11/PPARA/NDUFA13	4.30125356210168
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/867	82/9376	2.50575294680282	CD74/HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/TAPBP/HLA-G/HLA-DQA1/HLA-DPB1/PSME1/HLA-DMB/CTSL/HLA-DMA/HLA-C/HLA-DOA/NFYC/HLA-DQB1	4.37134656316824
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/867	98/9376	2.3173504695996	PLCG2/PIP5K1C/MYO10/WASF2/LYN/PTPRC/PIK3R1/RAC1/FCGR3A/VASP/NCF1/SPHK2/PRKCE/FCGR2A/DOCK1/INPPL1/INPP5D/WAS/FCGR2B/ASAP2/DNM2	4.18449554144126
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/867	105/9376	2.26585379249739	MAP1LC3A/ATG9B/SAMM50/FIS1/UBA52/FKBP8/RABGEF1/GABARAPL1/AMBRA1/ATF4/RAB5B/BNIP3L/ULK1/TOMM70/TFE3/SMURF1/SP1/HRAS/RELA/FUNDC1/NBR1/RHOT2	4.16361755708417
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/867	181/9376	1.91192082943024	CD74/HLA-DRA/HLA-DRB1/CTSD/HLA-DRB5/HLA-DPA1/CD14/HLA-DQA1/FCER1G/HLA-DPB1/TGFB1/HLA-DMB/ITGB2/FCGR3A/LSP1/PPP3CA/HLA-DMA/TCIRG1/MRC2/IL1B/MRC1/CEBPG/RAB5B/SPHK2/FCGR2A/RELA/HLA-DOA/NFYC/ITGAM/FCGR2B/JAK2/HLA-DQB1	3.95436252225919
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/867	50/9376	2.81171856978085	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/HLA-DPB1/TGFB1/HLA-DMB/CXCR4/HLA-DMA/HLA-DOA/CD86/HLA-DQB1	4.10000095149617
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/867	91/9376	2.25793122678936	PLCG2/LYN/PIK3R1/RAC1/PPP3CA/IKBKB/LILRB4/LILRB5/HRAS/RELA/CD79B/INPPL1/PTPN6/NFKBIB/LILRB2/LILRB3/INPP5D/FCGR2B/LILRB1	3.84895262311674
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	28/867	160/9376	1.89250288350634	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/CLDN5/HLA-DQA1/HLA-DPB1/PECAM1/HLA-DMB/PTPRC/ITGB2/CD34/ICAM2/HLA-DMA/HLA-C/ITGAL/CD2/HLA-DOA/CD86/ITGAM/SIGLEC1/VSIR/HLA-DQB1/JAML/PDCD1LG2	3.63458065981683
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/867	66/9376	2.45779595260564	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/HLA-DPB1/TGFB1/HLA-DMB/GATA3/HLA-DMA/IL1B/IL2RG/RELA/HLA-DOA/HLA-DQB1	3.79358476502435
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	28/867	169/9376	1.7917187062782	CTSD/IRS2/MAP1LC3A/ATG9B/VAMP8/CTSL/PIK3R1/UBA52/GABARAPL1/VPS11/UVRAG/DAPK3/AMBRA1/VPS33A/ULK1/PRKACB/ATG12/HRAS/NBR1/ATG16L2/MTMR14/ATG7/PLEKHM1/ITPR1/ATG4B/ZFYVE1/ATG13/CAMKK2	3.31521052234107
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	37/867	250/9376	1.60051672433679	HLA-E/HLA-A/RAB11FIP1/AP2B1/TGFBR1/PIP5K1C/RAB31/HLA-G/EHD2/DAB2/ACAP1/EGFR/AP2S1/ARFGAP2/CXCR4/FOLR2/IL2RG/HLA-C/CLTB/RAB5B/CHMP3/RBSN/SMURF1/ZFYVE27/SH3GLB2/SH3KBP1/CHMP1A/HRAS/RAB35/CBL/SNX12/ASAP2/CHMP2A/AP2A2/DNM2/SNX5/SH3GL1	3.07192638538681
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/867	180/9376	1.68222478533897	CD74/HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL5/TAPBP/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/PIK3R1/HCFC2/HLA-DMA/OAS3/IL1B/HLA-C/IKBKB/BIRC2/TRAF3/RELA/TYK2/HLA-DOA/JAK2/POU2F2/HLA-DQB1	2.94998759487469
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	36/867	248/9376	1.56981806005135	MYL9/GAPDH/DYNC1I2/AHNAK2/TNFSF10/CD14/AHNAK/TCF7L2/FLNA/PTPRC/RAC1/CSE1L/TUBA4A/CYFIP1/IL1B/VPS11/RAB5B/NCKAP1L/IKBKB/VPS33A/SNX33/PODXL/DCTN4/MAP2K7/BIRC2/EXOC7/HRAS/RELA/TUBB4B/S100A10/PLEKHM1/KLC1/TUBA3E/RHOJ/ELMO1/DNM2	2.9028871949648
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/867	116/9376	1.86453486059738	MYL9/THY1/PLCG2/CYBA/CLDN5/EZR/CYBB/PECAM1/ITGB2/PIK3R1/RAC1/CXCR4/PTK2B/VASP/NCF1/ITGAL/ACTN4/PXN/CTNND1/ITGAM	2.99062484109176
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/867	142/9376	1.75161232678656	ELOB/PIAS1/UBE2K/UBA1/UBE2O/UBE4A/UBA52/UBR5/HERC3/FBXW11/PIAS4/SMURF1/BIRC2/STUB1/CBL/TRIM37/UBE3B/MID1/ANAPC11/BRCA1/DDB1/HERC1/FBXW7	2.88070679019712
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/867	88/9376	1.96623676208451	CLU/C1QB/C1QA/SERPINE2/CD59/VWF/C1QC/ITGB2/C5AR1/F2RL3/F13A1/A2M/FGA/F10/VSIG4/ITGAM	2.90683054248856
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/867	112/9376	1.83456912176635	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/HLA-DPB1/TGFB1/HLA-DMB/GNAO1/HLA-DMA/IKBKB/BIRC2/RELA/TYK2/HLA-DOA/NFKBIB/JAK2/LAMC2/HLA-DQB1	2.83614202704156
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/867	52/9376	2.28764084819448	APOA1/LRPAP1/APOE/APOC3/SOAT1/PLTP/OSBPL5/NPC2/APOC1/VAPB/APOA4	2.97201645740777
NA	NA	hsa04518	Integrin signaling	24/867	154/9376	1.68534579607244	FN1/FLT1/SPP1/KDR/LIMS2/VWF/TLN1/VEGFA/TGFB1/EGFR/FLNA/ITGB2/PIK3R1/RAC1/ICAM2/FERMT2/ITGAL/ITGB4/ACTN4/FGA/PXN/CCND1/ITGAM/LAMC2	2.73724379364018
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/867	157/9376	1.65314173627488	C1QB/C1QA/MFGE8/BSG/C1QC/PECAM1/TGFB1/RAC1/VPS11/ATP8A2/STAB1/RAB5B/VPS33A/SLC2A1/SPHK2/DOCK1/CPT1A/PTPN6/PLA2G15/TGFBRAP1/PTGER4/DUSP4/JAK2/ELMO1	2.6343366878063
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/867	133/9376	1.70752139865234	HLA-E/HLA-A/TNFSF10/TYROBP/PLCG2/HLA-G/FCER1G/ITGB2/PIK3R1/RAC1/FCGR3A/PPP3CA/ICAM2/PTK2B/HCST/HLA-C/ITGAL/HRAS/PTPN6/SHC1/SH3BP2	2.62310000640815
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/867	193/9376	1.56891430757003	CXCL14/CCL21/RASGRP2/PLCG2/CCL5/CCL4/CCL3/LYN/PIK3R1/RAC1/CXCR4/PTK2B/CCL18/NCF1/IKBKB/PRKACB/GSK3A/HRAS/PXN/RELA/NFKBIB/SHC1/TIAM1/WAS/CXCL16/JAK2/GNB4/ELMO1	2.54911332628983
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/867	142/9376	1.67545526910018	KDR/GSTA1/IL1R2/CYBA/MEF2A/PECAM1/VEGFA/CTSL/PIK3R1/RAC1/HMOX1/NFE2L2/BMP4/IL1B/NCF1/PIAS4/IKBKB/MAP2K7/EDN1/RELA/GSTP1/ACVR2A	2.58881940972196
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/867	214/9376	1.51602367170068	HLA-E/HLA-A/ELOB/PLCG2/TAPBP/HLA-G/TNFRSF1B/PIK3R1/RAC1/CXCR4/GNAO1/PPP3CA/PTK2B/CD3D/HLA-C/FBXW11/CD3E/DCAF1/IKBKB/CD3G/MAP2K7/HRAS/PAK2/PXN/AP1S2/RELA/APOBEC3C/ITPR1/DDB1/GNB4	2.43745885076144
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/867	137/9376	1.65766675927563	CTSD/TNFSF10/CTSZ/CTSL/PIK3R1/TUBA4A/ATF4/IKBKB/CSF2RB/BIRC2/DFFA/CASP6/HRAS/RELA/NTRK1/CTSF/CTSO/CTSH/ITPR1/PARP1/TUBA3E	2.4751961270913
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/867	50/9376	2.16286043829296	HBB/HBA2/PECAM1/TGFB1/ITGB2/IL1B/HBA1/ITGAL/ACKR1/GYPC	2.63160569361229
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	31/867	227/9376	1.47684303055246	HLA-E/HLA-A/CCL5/CCL4/TAPBP/HLA-G/CCL3/VEGFA/EGFR/PIK3R1/AKAP13/RAC1/CXCR4/GNAO1/PPP3CA/PTK2B/CREB3L1/IL1B/HLA-C/CDKN1A/ATF4/IKBKB/PRKACB/SP1/HRAS/PXN/RELA/CCND1/PTGER4/ITPR1/GNB4	2.3214400855201
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/867	44/9376	2.21201635734508	APTX/NTHL1/RFC2/SMUG1/OGG1/NEIL2/TDG/PARP1/POLD3	2.57219197767766
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/867	37/9376	2.33822750085726	TCF7L2/TPM3/CDKN1A/HRAS/CCND1/NTRK1/RXRB/RET	2.60337392028574
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/867	76/9376	1.84981484854004	APOA1/APOC3/PLTP/SLC27A1/FADS2/FABP5/CPT1A/RXRB/ACOX3/CPT2/PPARA/EHHADH/OLR1	2.37435450454372
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/867	204/9376	1.4843159870638	FN1/KDR/TIMP3/IQGAP1/PLCG2/EZR/RDX/VEGFA/TGFB1/EGFR/FLNA/CTSL/PIK3R1/RAC1/WNT10B/WNT3/CDKN1A/WNT5B/PRKACB/HRAS/PXN/CCND1/PTPN6/CBL/DROSHA/ITPR1/TIAM1/ANK3	2.23237829320892
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/867	93/9376	1.74424228894594	MYL9/IQGAP1/TGFBR1/TCF7L2/WASF2/EGFR/RAC1/NLK/ARHGAP29/SMURF1/ACTN4/FARP2/CTNND1/PTPN6/WAS	2.30232997502414
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/867	110/9376	1.67130124777184	FLT1/GAPDH/ELOB/PLCG2/CYBB/VEGFA/EGFR/PIK3R1/HMOX1/EPAS1/ANGPT2/CDKN1A/SLC2A1/EDN1/RELA/EIF4E2/HK1	2.26059922397814
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/867	70/9376	1.85388037567968	IRS2/TNFRSF1B/IKBKB/ADIPOR2/SLC2A1/RELA/CPT1A/NFKBIB/RXRB/PPARA/JAK2/CAMKK2	2.28886645085241
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/867	173/9376	1.5002500150009	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/TNFSF10/CCL5/HLA-DQA1/HLA-DPB1/HLA-DMB/PIK3R1/FDPS/HLA-DMA/OAS3/IL1B/IKBKB/TRAF3/RELA/TYK2/HLA-DOA/NFKBIB/KPNA6/SLC25A4/JAK2/HLA-DQB1	2.11983166914076
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/867	149/9376	1.52416339611249	MT-ND3/MT-ND1/MT-ND2/MT-ND5/MT-ND4/NDUFA3/MT-ND6/MT-ND4L/NDUFB1/NDUFB10/GNAO1/NDUFA1/NDUFS7/NDUFS6/NDUFS8/PRKACB/NDUFB2/ITPR1/NDUFB11/GNB4/NDUFA13	2.0586640879572
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/867	205/9376	1.42432272765634	HLA-E/HLA-A/YWHAE/HLA-G/PSMC1/LYN/PIK3R1/CHD4/RAC1/PKM/CREB3L1/HLA-C/DLG1/CDKN1A/ATF4/YWHAH/PRKACB/ACTN4/RBPJ/HRAS/PXN/TRAF3/RELA/CCND1/HDAC2/YWHAZ/DDB1	1.96074358623791
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/867	196/9376	1.43455029070452	HLA-E/HLA-A/PLCG2/HLA-G/TCF7L2/MAP1LC3A/VEGFA/LYN/PIK3R1/RAC1/PPP3CA/UBA52/ANGPT2/HLA-C/CDKN1A/IKBKB/MAP2K7/HRAS/TRAF3/RELA/TYK2/CCND1/ITPR1/CD86/JAK2/GNB4	1.96246836651681
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/867	144/9376	1.50198641548123	C1QB/C1QA/CD14/TCF7L2/C1QC/C5AR1/ALDH7A1/LPIN1/IL1B/IKBKB/ADIPOR2/MAP2K7/TRAF3/RELA/IL17RC/CCND1/CPT1A/ACOX3/PPARA/CAMKK2	1.93767634687983
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/867	101/9376	1.60608448388091	FN1/TGFBR1/PLCG2/CYBB/VEGFA/TGFB1/PIK3R1/RAC1/IL1B/PRKCE/EDN1/HRAS/RELA/CCND1/JAK2	1.95475718813729
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/867	44/9376	1.96623676208451	DYNC1I2/ARHGDIB/ARHGDIA/CREB3L1/VAMP2/RAB5B/DCTN4/PRKACB	2.05058820609912
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/867	60/9376	1.80238369857747	HSPB1/KDR/PLCG2/VEGFA/PIK3R1/RAC1/PPP3CA/SPHK2/HRAS/PXN	1.99021001455906
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/867	77/9376	1.68534579607244	TGFBR1/TGFB1/PIK3R1/CTBP1/CDKN1A/IKBKB/HRAS/RELA/CCND1/SHC1/HDAC2/CBL	1.92749347697953
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/867	103/9376	1.57489837739779	C1QB/C1QA/TGFBR1/CCL5/CCL3/C1QC/TGFB1/PIK3R1/GNAO1/IL1B/CD3D/CD3E/IKBKB/CD3G/RELA	1.87264515138762
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/867	78/9376	1.6637387986869	FN1/WASF2/PIK3R1/RAC1/CLTB/CD2AP/DOCK1/PXN/SHC1/CBL/ELMO1/DNM2	1.87890862702169
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	21/867	157/9376	1.44649901924052	YWHAE/TGFBR1/BMP8B/TCF7L2/TGFB1/ITGB2/WNT10B/BMP4/LATS1/WNT3/DLG1/FBXW11/NKD2/YWHAH/APC/NKD1/WNT5B/BIRC2/CCND1/YWHAZ/DLG5	1.80087825065861
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/867	203/9376	1.38508303930091	FN1/FLT1/MYL9/SPP1/KDR/PIP5K1C/VWF/TLN1/VEGFA/EGFR/FLNA/PIK3R1/RAC1/MYLK3/VASP/ITGB4/ACTN4/BIRC2/EMP2/DOCK1/HRAS/PAK2/PXN/CCND1/SHC1/LAMC2	1.77052734315023
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/867	70/9376	1.69939034437304	ELOB/VEGFA/TGFB1/PIK3R1/RAC1/EPAS1/CDKN1A/TFE3/SLC2A1/HRAS/PAK2	1.87474866606618
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/867	46/9376	1.88074820721127	PSMA7/PSMC1/PSMC3/PSME1/PSMF1/PSMD3/ADRM1/PSMD1	1.91137449649518
NA	NA	hsa04517	IgSF CAM signaling	36/867	299/9376	1.30205645114627	MYL9/KDR/IQGAP1/PLCG2/EZR/RDX/LYN/ITGB2/PIK3R1/RAC1/CD84/ICAM2/PPFIA1/MYLK3/TUBA4A/ITGAL/CD2AP/ACTN4/RASA1/PAK2/FGA/PXN/MYL6/CD2/MAGI2/TUBB4B/PTPN6/LRFN4/ROBO4/CD86/INPP5D/ITGAM/TUBA3E/ANK3/JAML/MYL6B	1.69437083403849
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/867	106/9376	1.53032578181106	IL1R2/TCF7L2/ZEB1/EGFR/PIK3R1/FOLR2/CREB3L1/CDKN1A/ATF4/IKBKB/KLK3/HRAS/RELA/CCND1/GSTP1	1.75271672776149
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/867	216/9376	1.3517877739331	APOA1/TNFSF10/CCL5/CD14/CYBA/CCL3/CYBB/LYN/PIK3R1/RAC1/NFE2L2/PPP3CA/IL1B/ATF4/NCF1/IKBKB/MAP2K7/CASP6/HRAS/TRAF3/RELA/RXRB/ITPR1/OLR1/JAK2/APOA4/POU2F2	1.66961295437449
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/867	90/9376	1.56206587210047	IRS2/EHMT2/PIK3R1/CREB3L1/ATF4/ULK1/PRKACB/ADIPOR2/HRAS/RELA/EIF4E2/ATG13/CAMKK2	1.71021242158079
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/867	90/9376	1.56206587210047	EGFR/PIK3R1/PPP3CA/CD3D/EML4/CD3E/IKBKB/CD3G/HRAS/RELA/PTPN6/NFKBIB/JAK2	1.71021242158079
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/867	32/9376	2.02768166089965	ATG9B/GABARAPL1/ATG12/ATG7/ATG4B/ATG13	1.85875909237425
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	39/867	333/9376	1.26653989629768	FN1/HLA-E/HLA-A/SPP1/HLA-G/TCF7L2/VWF/PSMC1/VEGFA/EGFR/PIK3R1/CHD4/WNT10B/BCAP31/PKM/TCIRG1/CREB3L1/WNT3/HLA-C/DLG1/CDKN1A/IKBKB/APC/WNT5B/PRKACB/ITGB4/RBPJ/PPP2R3C/HRAS/PXN/TRAF3/RELA/TYK2/CCND1/HDAC2/PTGER4/LAMC2/ATP6V1E1/TUBG2	1.58082574763856
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/867	41/9376	1.84634427659155	RPA1/TOP3B/BRCC3/BRCA1/POLD3/RAD51D/RBBP8	1.73355551497084
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/867	298/9376	1.27013616342708	IL1RL1/PRLR/TNFSF10/PRL/TGFBR1/CXCL14/TNFRSF11B/CCL21/IL1R2/CCL5/BMP8B/CCL4/INHA/CCL3/TNFRSF1B/TGFB1/CSF1R/TNFRSF21/LTB/CXCR4/IL7R/EBI3/BMP4/CCL18/IL1B/IL2RG/INHBB/CSF2RB/TNFRSF10D/IL17RC/IL1RN/CSF2RA/ACVR2A/LIFR/CXCL16	1.5126961288962
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/867	42/9376	1.80238369857747	GPX4/MAP1LC3A/SLC40A1/CYBB/FTL/HMOX1/ATG7	1.66352284321201
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/867	103/9376	1.46990515223794	FN1/HSPB1/IL1R2/CD14/TGFB1/ITGB2/PIK3R1/IL1B/RAB5B/PRKACB/ACTN4/RELA/ITGAM/LAMC2	1.53064548370008
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/867	253/9376	1.2823283230986	MYL9/CBX3/PLCG2/CCL5/CAPNS1/CD14/CAST/TLN1/WASF2/MAP1LC3A/EGFR/PIK3R1/RAC1/UBA52/IL1B/FBXW11/IKBKB/ACTN4/GSK3A/ATG12/PRKCE/DOCK1/PXN/RELA/NFKBIB/SHARPIN/UBE2V1/ITPR1/ELMO1/HK1	1.45312105958499
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/867	68/9376	1.59033855756836	CD14/TCF7L2/CSF1R/PIK3R1/SPI1/IKBKB/HRAS/RELA/CCND1/ITGAM	1.55949269208364
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/867	122/9376	1.41826913986424	PLCG2/PIK3R1/NCOA3/BMP4/NCOA2/DIO2/PRKACB/SLC2A1/HRAS/CCND1/MED1/MED12/RXRB/HDAC2/SLC16A10/MED16	1.48431787031745
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/867	87/9376	1.49162788847791	MT-CO2/COX7A1/MT-CYB/MT-CO3/TPM1/TPM3/COX4I1/UQCRQ/UQCRB/UQCR10/SLC9A6/UQCRC1	1.47050864160573
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/867	170/9376	1.33588438835742	MYL9/CLDN5/SYNPO/EZR/RDX/RAC1/TUBA4A/DLG1/VASP/AMOTL2/PRKACB/ACTN4/MAP2K7/PRKCE/MYL6/CCND1/AMOTL1/TIAM1/WAS/TUBA3E/MYL6B	1.41070017157585
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/867	170/9376	1.33588438835742	TGFBR1/GSTA1/PLCG2/TCF7L2/TGFB1/EGFR/PIK3R1/HMOX1/NFE2L2/WNT10B/WNT3/CDKN1A/APC/BRD7/WNT5B/HRAS/SMARCD2/CCND1/GSTP1/SHC1/ARID1A	1.41070017157585
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/867	201/9376	1.29125996315998	FLT1/HPGD/NUPR1/IL1R2/CD14/IGFBP3/ZEB1/CSF1R/SPI1/ATF1/CCNT1/CDKN1A/TFE3/CDKN2C/SP1/BIRC2/AFF1/RELA/NTRK1/TAF15/RXRB/HDAC2/CD86/ITGAM	1.33239105256812
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/867	107/9376	1.41495542692063	PPP3CA/PKM/CREB3L1/ATF4/PHKB/PRKACB/SLC2A1/PPP4R3A/CPT1A/PHKG2/ITPR1/PPARA/PYGM/PYGB	1.37794797742527
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/867	71/9376	1.52314115372744	PRLR/PRL/PIK3R1/GALT/HRAS/RELA/CISH/CCND1/SHC1/JAK2	1.41236125962506
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/867	71/9376	1.52314115372744	SLC16A3/EGFR/PIK3R1/PKM/SLC2A1/HRAS/IDH1/NTRK1/RET/HK1	1.41236125962506
Organismal Systems	Immune system	hsa04611	Platelet activation	16/867	126/9376	1.37324472272569	RASGRP2/PLCG2/VWF/FCER1G/TLN1/VAMP8/LYN/PIK3R1/MYLK3/VASP/F2RL3/PRKACB/APBB1IP/FCGR2A/FGA/ITPR1	1.34636870173114
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/867	117/9376	1.38644899890575	BRD9/BRD8/CHD4/ZNHIT1/DMAP1/MBD3/BRD7/BAZ1A/ING3/RUVBL2/SMARCD2/SMARCA1/BPTF/HDAC2/ARID1A	1.3426382037111
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/867	108/9376	1.40185398778248	UPF2/SRRM1/CSE1L/POM121C/IPO9/NUP214/TNPO3/PHAX/DDX19B/KPNA6/NUP93/NUP88/POM121/DDX19A	1.34073538855522
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/867	21/9376	2.05986708408854	CHPF/CHSY1/CHPF2/CHST12	1.55201202265147
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/867	174/9376	1.30517440241817	SEC62/SIL1/RRBP1/SSR4/ATXN3/NFE2L2/BCAP31/MAN1B1/MAN1A2/ATF4/HSPBP1/GANAB/ERLEC1/SELENOS/PRKCSH/MAP2K7/DNAJC1/SVIP/STUB1/RNF185/SEC61A2	1.29699271763872
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/867	155/9376	1.32562413959891	KCNK3/CYP11A1/TCF7L2/EGFR/WNT10B/CREB3L1/WNT3/CDKN1A/ATF4/RBBP5/APC/WNT5B/PRKACB/CDKN2C/SP1/CCND1/ITPR1/ASH2L/HSD3B1	1.30481624873067
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/867	63/9376	1.5449003130664	POLR2I/POLR2L/RFC2/XPC/RPA1/ERCC6/POLR2G/DDB1/POLD3	1.38515526072886
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/867	109/9376	1.388992942023	SPP1/CCL5/CD14/CCL4/CCL3/PIK3R1/RAC1/IL1B/IKBKB/MAP2K7/TRAF3/RELA/TYK2/CD86	1.30389107917793
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/867	138/9376	1.33219664677465	FN1/PIP5K1C/FYB1/WASF2/PIK3R1/RAC1/PTK2B/IL1B/IKBKB/RPS6KA2/MAP2K7/FCGR2A/DOCK1/PXN/RELA/WAS/ELMO1	1.25487865933259
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/867	120/9376	1.3517877739331	YWHAE/PLCG2/ARHGDIB/ARHGDIA/PIK3R1/RAC1/ATF4/IKBKB/RPS6KA2/MAP2K7/HRAS/RELA/NTRK1/NFKBIB/SHC1	1.23798566825653
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/867	130/9376	1.33099103894952	TGFBR1/RXFP1/VEGFA/TGFB1/EGFR/PIK3R1/GNAO1/CREB3L1/ATF4/PRKACB/MAP2K7/EDN1/HRAS/RELA/SHC1/GNB4	1.21301701516749
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/867	57/9376	1.51779679880208	FADS1/FADS2/CPT1A/MECR/ACOX3/CPT2/EHHADH/TECR	1.25160721562883
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/867	122/9376	1.32962731862272	PTPRC/PIK3R1/PPP3CA/CD3D/DLG1/CD3E/IKBKB/CD3G/MAP2K7/PPP2R3C/HRAS/PAK2/RELA/PTPN6/NFKBIB	1.16975333091832
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/867	23/9376	1.88074820721127	RFC2/RPA1/MSH2/POLD3	1.34988304902268
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/867	49/9376	1.5449003130664	GALNT6/GALNT15/COLGALT1/POMT1/PLOD3/GALNT1/GALNT17	1.22067495519042
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/867	49/9376	1.5449003130664	MAOA/CREB3L1/CDK5/ATF4/PRKACB/GPSM1/RELA	1.22067495519042
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/867	300/9376	1.18957324106113	FLT1/HSPB1/KDR/TGFBR1/RASGRP2/CD14/VEGFA/TGFB1/EGFR/CSF1R/FLNA/RAC1/PPP3CA/IL1B/ANGPT2/NLK/ATF4/IKBKB/RPS6KA2/PRKACB/MAP2K7/RASA1/HRAS/PAK2/RELA/DUSP3/NTRK1/FLT3LG/RET/STMN1/DUSP4/RPS6KA4/TAOK3	1.0652372480749
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/867	143/9376	1.28561634443987	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/HLA-DPB1/C1QC/HLA-DMB/FCGR3A/HLA-DMA/ACTN4/FCGR2A/HLA-DOA/CD86/HLA-DQB1	1.09858985060749
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/867	105/9376	1.33891360465755	CCL21/PLCG2/CD14/CCL4/LYN/LTB/IL1B/PIAS4/IKBKB/BIRC2/TRAF3/RELA/PARP1	1.1147469344804
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/867	77/9376	1.40445483006037	TGFBR1/VEGFA/TGFB1/EGFR/PIK3R1/RAC1/CDKN1A/IKBKB/RELA/CCND1	1.13750467448964
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/867	41/9376	1.58258080850705	VEGFA/EGFR/DAPK3/CDKN1A/HRAS/CCND1	1.19329237691644
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	26/867	232/9376	1.2119476593883	FN1/MYL9/IQGAP1/PIP5K1C/EZR/RDX/WASF2/EGFR/ITGB2/PIK3R1/RAC1/CXCR4/MYLK3/CYFIP1/PIP4K2A/NCKAP1L/APC/ITGAL/ITGB4/ACTN4/DOCK1/HRAS/PAK2/PXN/TIAM1/ITGAM	1.04342306764227
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/867	87/9376	1.36732556443808	TGFBR1/TCF7L2/TGFB1/EGFR/PIK3R1/RAC1/CDKN1A/MSH2/APC/HRAS/CCND1	1.09870784275732
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/867	16/9376	2.02768166089965	MIF/MAOA/IL4I1	1.31321730981541
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/867	16/9376	2.02768166089965	HEXB/GBGT1/NAGA	1.31321730981541
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/867	78/9376	1.38644899890575	TPI1/PLCG2/PIP5K1C/PI4K2A/PIP4K2A/IP6K1/FIG4/INPPL1/MTMR14/INPP5D	1.09395798374961
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/867	157/9376	1.23985630220616	HLA-E/HLA-A/TGFBR1/IGFBP3/HLA-G/TGFB1/PIK3R1/RAD9A/PPP3CA/HIPK2/HLA-C/CDKN1A/FBXW11/HRAS/RELA/CCND1/SLC25A4/ITPR1	0.967419813510914
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/867	34/9376	1.59033855756836	POLR2I/POLR2L/POLR1A/POLR2G/POLR1E	1.10071935195536
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/867	43/9376	1.50897239880904	APOA1/PLA2G12A/AGPAT1/SLC27A1/APOA4/AGPAT2	1.06776025578693
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/867	138/9376	1.25383213814085	IRS2/PIK3R1/PHKB/IKBKB/PRKACB/EXOC7/HRAS/INPPL1/EIF4E2/SHC1/CBL/PHKG2/PRKAR2B/PYGM/PYGB/HK1	0.958855353593587
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/867	109/9376	1.28977916044993	IRS2/PIK3R1/CREB3L1/IKBKB/RPS6KA2/SLC2A1/PRKCE/RELA/SLC27A1/CPT1A/PPARA/PYGM/PYGB	0.971329865979914
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/867	71/9376	1.3708270383547	PLCG2/CCL5/EGFR/LYN/RAC1/TCIRG1/IKBKB/RELA/ATP6V1E1	1.00114804438907
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/867	178/9376	1.21509013387245	NOTUM/TCF7L2/RAC1/CTBP1/PPP3CA/WNT10B/SFRP1/WNT3/NLK/FBXW11/NKD2/APC/NKD1/WNT5B/PRKACB/TLE1/CCND1/TBL1X/CHD8/ANKRD6	0.924782735673813
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/867	100/9376	1.29771626297578	TNFSF10/CXCL14/CCL21/CCL5/CCL4/CCL3/TNFRSF1B/CSF1R/CXCR4/CCL18/IL2RG/TNFRSF10D	0.955384330617402
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/867	139/9376	1.24481176304631	CTSD/KRT18/KRT19/EGFR/PIK3R1/GNAO1/NCOA3/NCOA2/CREB3L1/EBAG9/ATF4/PRKACB/SP1/HRAS/SHC1/ITPR1	0.928175573337068
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/867	110/9376	1.27805389535493	EMP3/TGFBR1/BMP8B/TGFB1/BMP4/INHBB/LTBP1/SMURF1/SP1/HFE/HDAC2/HAMP/ACVR2A	0.936343291703668
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/867	53/9376	1.42830406302366	AP2B1/ATP2B4/AP2S1/CLTB/PRKACB/AP2A2/DNM2	0.998086570448125
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/867	26/9376	1.6637387986869	APOA1/TCN2/SLC5A6/APOA4	1.08176767189538
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/867	35/9376	1.5449003130664	TPI1/ENOSF1/PMM1/GMPPA/HK1	1.03088523320429
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/867	200/9376	1.18957324106113	GAPDH/TNFSF10/CLDN5/EZR/MYO10/WASF2/RAC1/NCL/TUBA4A/CYFIP1/IL1B/NCKAP1L/MYO1C/IKBKB/FCGR2A/PAK2/RELA/MYO1F/TUBB4B/PTPN6/NFKBIB/TUBA3E	0.865010253804629
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/867	73/9376	1.33327013319429	PLCG2/EGFR/PIK3R1/EML4/CDKN1A/HRAS/CCND1/RXRB/RET	0.912435638205107
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/867	27/9376	1.60211884317997	FADS1/FADS2/ACOX3/TECR	1.0000862260219
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/867	36/9376	1.50198641548123	RNASEH2C/RFC2/MCM3/RPA1/POLD3	0.96322046675151
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	23/867	212/9376	1.17324976605515	FLT1/KDR/RASGRP2/TLN1/FYB1/VEGFA/EGFR/CSF1R/ITGB2/PIK3R1/RAC1/GNAO1/ANGPT2/VASP/F2RL3/ITGAL/APBB1IP/FARP2/HRAS/MAGI2/CTNND1/TIAM1/ITGAM	0.814430392652436
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/867	65/9376	1.33099103894952	KCNK3/CYP11A1/CREB3L1/ATF4/PRKACB/SP1/ITPR1/HSD3B1	0.854733402385859
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/867	37/9376	1.46139218803579	HBB/APOA1/HBA2/IL1B/HBA1	0.897587584014286
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/867	19/9376	1.70752139865234	GALNS/HEXB/HGSNAT	0.985380560442473
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/867	134/9376	1.21055621546248	MYL9/CALD1/ADM/RAMP1/MYLK3/EDNRA/PLA2G12A/PRKACB/PRKCE/EDN1/MYL6/ITPR1/RAMP2/PRKCH/MYL6B	0.783598161185048
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/867	47/9376	1.38054921593168	PKM/ALDH7A1/AKR1A1/GRHPR/HAGH/ACSS2	0.834830176404923
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/867	47/9376	1.38054921593168	IRS2/PIK3R1/PKM/IKBKB/PRKCE/HK1	0.834830176404923
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/867	38/9376	1.42293449887695	GALT/PMM1/GMPPA/HEXB/HK1	0.833861457995091
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/867	38/9376	1.42293449887695	PTPRC/IL7R/CD3D/IL2RG/CD3E	0.833861457995091
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/867	20/9376	1.62214532871972	CYB5R3/GMPPA/NPL	0.889032547955343
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/867	48/9376	1.3517877739331	ALDH7A1/OXCT2/DBT/IL4I1/EHHADH/IVD	0.779943273574649
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/867	168/9376	1.1586752347998	PRLR/PRL/PIAS1/EGFR/PIK3R1/IL7R/IL2RG/CDKN1A/PIAS4/CSF2RB/HRAS/TYK2/CISH/CCND1/PTPN6/CSF2RA/LIFR/JAK2	0.66242552757219
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/867	98/9376	1.21385024598075	ATP2B4/KCNK3/CYP11A1/ATF1/CREB3L1/ATF4/PRKACB/PRKCE/ITPR1/NR4A2/HSD3B1	0.679284231108618
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/867	30/9376	1.44190695886198	FOLR2/IL1B/IKBKB/RELA	0.773810297355067
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/867	59/9376	1.28305280237718	GSTA1/GPX4/PGD/GPX7/GPX3/IDH1/GSTP1	0.696163648735448
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/867	59/9376	1.28305280237718	TCF7L2/EGFR/PIK3R1/CDKN1A/APC/HRAS/CCND1	0.696163648735448
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/867	69/9376	1.25383213814085	PLCG2/FCER1G/LYN/PIK3R1/RAC1/MAP2K7/HRAS/INPP5D	0.675495128834741
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/867	119/9376	1.18139435705078	CCL5/TNFRSF1B/PIK3R1/CREB3L1/IL1B/ATF4/IKBKB/MAP2K7/BIRC2/EDN1/TRAF3/RELA/RPS6KA4	0.635649992969343
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/867	79/9376	1.23200911042004	AP2B1/SYT1/AP2S1/TCIRG1/CLTB/VAMP2/ATP6V1E1/AP2A2/DNM2	0.661002487999365
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/867	99/9376	1.20158913238498	EGFR/PIK3R1/NCOA3/CDKN1A/PRKACB/CDKN2C/SP1/HRAS/CCND1/MED1/SHC1	0.643630861315409
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/867	80/9376	1.21660899653979	KDR/PLCG2/VEGFA/EGFR/PIK3R1/HRAS/EIF4E2/SHC1/JAK2	0.621053983217216
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/867	31/9376	1.39539383115675	SMOX/ALDH7A1/ACOX3/EHHADH	0.703844965377344
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/867	31/9376	1.39539383115675	SEC62/SRP14/OXA1L/SEC61A2	0.703844965377344
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/867	22/9376	1.47467757156338	AOC1/MAOA/ALDH7A1	0.711487533014345
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/867	32/9376	1.3517877739331	DBT/ACOX3/EHHADH/ACSS2	0.636275559118011
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/867	133/9376	1.13834759910156	TNFSF10/TGFBR1/IRS2/TGFB1/EGFR/PIK3R1/IL7R/GABARAPL1/NLK/CDKN1A/IKBKB/ATG12/HRAS/CCND1	0.512916766589804
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/867	362/9376	1.07545546655451	FN1/FLT1/SPP1/KDR/YWHAE/PRLR/PRL/VWF/VEGFA/EGFR/CSF1R/PIK3R1/RAC1/IL7R/CREB3L1/IL2RG/ANGPT2/CDKN1A/ATF4/YWHAH/IKBKB/ITGB4/PPP2R3C/HRAS/MAGI2/RELA/CCND1/NTRK1/EIF4E2/FLT3LG/RET/YWHAZ/BRCA1/JAK2/LAMC2/GNB4	0.46734988728011
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/867	42/9376	1.28741692755534	AOC1/MAOA/ALDH7A1/IL4I1/EHHADH	0.595880281917205
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/867	62/9376	1.22096960226216	NCOR2/CTBP1/APH1A/NUMBL/RBPJ/TLE1/HDAC2	0.557206516750003
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/867	144/9376	1.12648981161092	PSMA7/PSMC1/PSMC3/PIK3R1/ATXN3/AMBRA1/ULK1/SP1/RBPJ/PSMD3/SLC25A4/ITPR1/ADRM1/ATG13/PSMD1	0.488252885976612
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/867	93/9376	1.16282819263063	FN1/PIK3R1/CDKN1A/IKBKB/BIRC2/TRAF3/RELA/CCND1/RXRB/LAMC2	0.503712613809461
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/867	23/9376	1.41056115540845	POMT1/FKRP/FKTN	0.629248563590997
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/867	23/9376	1.41056115540845	PCYOX1/FDPS/DHDDS	0.629248563590997
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/867	83/9376	1.17263517738775	PRDX5/PEX6/SLC25A17/PEX12/PEX19/IDH1/ACOX3/PEX26/EHHADH	0.504250454222947
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/867	73/9376	1.18512900728382	MAP1B/SUPT5H/CXCR4/MAP1A/CCNT1/TNPO3/PIN1/APOBEC3C	0.506851010896944
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/867	63/9376	1.20158913238498	EHMT2/COLGALT1/ALDH7A1/AASS/PLOD3/SETD1A/EHHADH	0.512446479719299
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/867	63/9376	1.20158913238498	TCF7L2/WNT10B/BMP4/WNT3/CDKN1A/APC/WNT5B	0.512446479719299
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/867	33/9376	1.31082450805634	VAMP8/VAMP2/VTI1B/USE1	0.57093277595934
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/867	43/9376	1.25747699900754	ALDH7A1/CPT1A/ACOX3/CPT2/EHHADH	0.540154450345124
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/867	187/9376	1.09877936704723	YWHAE/CCL5/CYBA/MAP1LC3A/CYBB/OAS3/IL1B/GABARAPL1/IKBKB/BIRC2/ATG12/BRCC3/TRAF3/RELA/TYK2/NFKBIB/GPSM3/SHARPIN/ITPR1	0.435520740161997
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/867	156/9376	1.1091591991246	YWHAE/CLDN5/PIAS1/EGFR/PIK3R1/OAS3/CDKN1A/YWHAH/IKBKB/HRAS/TRAF3/RELA/TYK2/CCND1/YWHAZ/PPARA	0.438846970320865
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/867	115/9376	1.12844892432676	MEF2A/EGFR/AKAP13/GATA3/CREB3L1/CDKN1A/ATF4/PRKACB/SP1/RXRB/ITPR1/NR4A2	0.442391093488281
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/867	136/9376	1.11323699029785	PIK3R1/OAS3/IL1B/CD3D/IL2RG/CD3E/IKBKB/CD3G/TRAF3/RELA/TYK2/CCND1/NFKBIB/FCGR2B	0.424597772542786
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/867	75/9376	1.15352556708958	GSTA1/PIK3R1/CDKN1A/MSH2/BIRC2/GSTP1/ATP7A/BRCA1	0.426091082258165
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/867	65/9376	1.16461715908083	PNPLA2/ALDH7A1/LPIN1/AGPAT4/AKR1A1/AGPAT1/AGPAT2	0.425098470698205
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/867	86/9376	1.13172929910678	PLCG2/EGFR/PIK3R1/CDKN1A/MAP2K7/HRAS/PAK2/SHC1/CBL	0.391723543829425
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/867	15/9376	1.44190695886198	ST3GAL5/HEXB	0.546727944987397
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/867	56/9376	1.1586752347998	FBXW11/DISP1/SMURF1/PRKACB/KIF3A/CCND1	0.380146618840245
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/867	98/9376	1.10350022361886	PLCG2/PIP5K1C/PIK3R1/PI4K2A/PIP4K2A/IP6K1/INPPL1/MTMR14/ITPR1/INPP5D	0.328763100075354
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/867	67/9376	1.12985246776498	GAPDH/TPI1/PKM/ALDH7A1/AKR1A1/ACSS2/HK1	0.340480323446985
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/867	36/9376	1.20158913238498	AGL/PYGM/PYGB/HK1	0.386812814449866
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/867	36/9376	1.20158913238498	GALNT6/GALNT15/GALNT1/GALNT17	0.386812814449866
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/867	194/9376	1.0591326888548	MYL9/DYNC1I2/TPM1/MYO10/TPM3/TUBA4A/MYO1C/DCTN4/MYL6/KIF3A/MYO1F/TUBB4B/DNAL1/DNALI1/KLC1/TUBA3E/TUBG2/MYL6B/MYO19	0.265653641429738
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/867	99/9376	1.09235375671362	PLCG2/PIK3R1/HTR2A/IL1B/PRKACB/PRKCE/NTRK1/PTGER4/ITPR1/PRKCH	0.294865736441498
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/867	78/9376	1.1091591991246	C1QB/C1QA/CD14/C1QC/ITGB2/IL1B/RELA/ITGAM	0.309007340477523
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/867	26/9376	1.24780409901517	PLA2G12A/FADS2/ACOX3	0.403873427028979
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/867	163/9376	1.06152659548121	TGFBR1/TGFB1/PIK3R1/PTK2B/CREB3L1/CDKN1A/ATF4/IKBKB/MAP2K7/HRAS/TRAF3/RELA/TYK2/YWHAZ/JAK2/DDB1	0.252936832822791
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/867	195/9376	1.05370123916837	PLCG2/CYBA/VWF/CYBB/ITGB2/PIK3R1/RAC1/FCGR3A/C5AR1/NCF1/ITGAL/FCGR2A/FGA/RELA/HDAC2/ATG7/FPR3/SLC25A4/ITGAM	0.241887008985602
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/867	238/9376	1.04507962354492	FLT1/KDR/RASGRP2/PLCG2/VEGFA/EGFR/CSF1R/PIK3R1/RAC1/ANGPT2/RAB5B/IKBKB/PLA2G12A/PRKACB/RASA1/HRAS/PAK2/RELA/NTRK1/SHC1/FLT3LG/TIAM1/GNB4	0.224853218021448
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/867	37/9376	1.16911375042863	GALT/PMM1/GMPPA/HK1	0.328992138590467
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/867	38/9376	1.13834759910156	QPRT/SIRT2/NT5C/NADSYN1	0.272767369423111
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/867	50/9376	1.08143021914648	AOC1/MAOA/SMOX/ALDH7A1/PYCR1	0.18428026380582
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/867	61/9376	1.06370185489818	ATP2B4/ATOX1/SLC40A1/FTL/HMOX1/ATP7A	0.15932410645821
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/867	72/9376	1.05139049083686	IKBKB/ATG12/TRAF3/RELA/PIN1/NFKBIB/OTUD5	0.139723703401297
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/867	18/9376	1.20158913238498	HEXB/AGA	0.27325478327951
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/867	18/9376	1.20158913238498	CD320/TCN2	0.27325478327951
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/867	148/9376	1.02297453162505	TCF7L2/EGFR/PIK3R1/WNT10B/NCOA3/WNT3/CDKN1A/APC/WNT5B/SP1/HRAS/CCND1/SHC1/BRCA1	0.0899248363622823
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/867	105/9376	1.02993354204427	PLCG2/FCER1G/PIK3R1/LSP1/PPP3CA/IL1B/IKBKB/HRAS/RELA/ITPR1	0.0984567269458102
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/867	116/9376	1.02549417332856	GAPDH/TPI1/PGD/PKM/IDH1/H6PD/CS/ACOX3/SDSL/ACSS2/HK1	0.0881902067046887
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/867	51/9376	1.06022570504557	PLD3/LPCAT1/PLA2G12A/PAFAH1B2/GDPD3	0.137657058693144
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/867	51/9376	1.06022570504557	PLCG2/TCIRG1/PRKACB/SEC61A2/ATP6V1E1	0.137657058693144
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/867	62/9376	1.04654537336756	IRS2/PIK3R1/CLPB/PRKACB/HRAS/HDAC2	0.117370828835537
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	14/867	150/9376	1.00933487120338	TGFBR1/TCF7L2/TGFB1/EGFR/PIK3R1/WNT10B/WNT3/CDKN1A/APC/WNT5B/HRAS/CCND1/SHC1/RXRB	0.03678774434483
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/867	41/9376	1.05505387233803	MAOA/ALDH7A1/GRHPR/SDSL	0.112766100807643
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/867	30/9376	1.08143021914648	PIGU/PIGM/MPPE1	0.142590065233864
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/867	19/9376	1.13834759910156	LIAS/DBT	0.192679733783646
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	13/867	140/9376	1.00418520349316	SPP1/TGFBR1/MAP1LC3A/MEF2A/MYLK3/APLN/PRKACB/SPHK2/PRKCE/HRAS/CCND1/ITPR1/GNB4	0.0159255544013368
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/867	184/9376	0.999147485080989	MYL9/SEMA3B/DPYSL2/PLCG2/SEMA3A/PIK3R1/RAC1/CXCR4/PPP3CA/CDK5/WNT5B/RASA1/HRAS/PAK2/EPHB4/SEMA6B/SEMA6D	-0.00372787907842954
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/867	75/9376	1.00933487120338	GAPDH/TPI1/PKM/IDH1/CS/SDSL/PYCR1	0.0259077719053098
NA	NA	hsa04519	Cadherin signaling	37/867	404/9376	0.990418765059897	KDR/YWHAE/KRT8/KRT7/KRT18/TCF7L2/KRT19/DSP/EGFR/RAC1/WNT10B/PTK2B/LATS1/CYFIP1/ATN1/WNT3/VASP/LHFPL2/AMOTL2/APH1A/NCKAP1L/YWHAH/MYO1C/IKBKB/APC/WNT5B/ACTN4/HRAS/RELA/MYO1F/PCDH20/AMOTL1/CTNND1/YWHAZ/ANKRD6/DCHS1/TAOK3	-0.0628381607306228
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/867	31/9376	1.04654537336756	CS/GRHPR/ACSS2	0.0828559378645955
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/867	76/9376	0.996054149213865	PLCG2/EGFR/PIK3R1/CDKN1A/HRAS/CCND1/SHC1	-0.0110245762408274
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/867	20/9376	1.08143021914648	SOAT1/FDFT1	0.116362065045694
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/867	154/9376	0.983118381042256	MYL9/EEF2/EGFR/GNAO1/PPP3CA/MYLK3/CDKN1A/PRKACB/HRAS/MYL6/CCND1/ITPR1/CAMKK2/MYL6B	-0.0674245132654138
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/867	99/9376	0.983118381042256	PIP5K1C/WASF2/EGFR/SLC44A2/PIK3R1/RAC1/SP1/HRAS/WAS	-0.0538993884324124
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/867	254/9376	0.979247836235003	FLT1/KDR/PLCG2/ATP2B4/VEGFA/EGFR/CXCR4/PPP3CA/MYLK3/PTK2B/HTR2A/EDNRA/PHKB/PRKACB/SPHK2/NTRK1/RET/PTAFR/MCOLN1/SLC25A4/PHKG2/ITPR1/SLN	-0.107026453708887
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/867	144/9376	0.976291170062796	PIK3R1/WNT10B/BMP4/WNT3/INHBB/APC/WNT5B/JARID2/HRAS/ACVR2A/LIFR/JAK2/KAT6A	-0.0915164983846738
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/867	122/9376	0.975060033656664	PLCG2/IGFBP3/IRS2/PIK3R1/CREB3L1/ATF4/PRKACB/HRAS/SHC1/ITPR1/JAK2	-0.0885048266782112
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/867	55/9376	0.983118381042256	PSAP/CERK/SGMS1/SPHK2/HEXB	-0.0400792982887706
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/867	89/9376	0.972072107097961	EGFR/TUBA4A/HTR2A/PRKACB/HRAS/TUBB4B/ITPR1/TUBA3E	-0.0844989623892156
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/867	78/9376	0.970514299234022	PABPC4/CNOT10/DCPS/DHX36/TOB2/DIS3/CNOT1	-0.083467981158518
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/867	67/9376	0.968444972369984	PPP3CA/ATF4/RPS6KA2/PRKACB/HRAS/ITPR1	-0.0827390206652952
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/867	168/9376	0.965562695666502	TNFSF10/CYBB/FTL/IL1B/CHMP3/BIRC2/CHMP1A/TYK2/SHARPIN/SLC25A4/PARP1/JAK2/PYGM/PYGB/CHMP2A	-0.14376628791546
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/867	101/9376	0.963650690328548	TCF7L2/GNAO1/WNT10B/CREB3L1/WNT3/WNT5B/PRKACB/EDN1/HRAS	-0.117234603844535
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/867	33/9376	0.983118381042256	IDH1/CS/DBT	-0.0310087181815317
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/867	56/9376	0.965562695666502	MAN1B1/MAN1A2/GANAB/DHRSX/DPM3	-0.0825032641096688
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/867	56/9376	0.965562695666502	CD14/ITGB2/IL1B/RELA/ITGAM	-0.0825032641096688
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/867	158/9376	0.958229308104478	PIK3R1/WNT10B/LPIN1/WNT3/LAMTOR4/NPRL2/IKBKB/ULK1/RPS6KA2/WNT5B/HRAS/EIF4E2/ATP6V1E1/GRB10	-0.169019878715754
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/867	10/9376	1.08143021914648	MPST	0.0822364684849567
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/867	69/9376	0.940374103605637	PPP3CA/EDNRA/PRKACB/EDN1/PTGER4/ITPR1	-0.158675740833291
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/867	69/9376	0.940374103605637	MAOA/PPP3CA/CREB3L1/ATF4/PRKACB/HDAC2	-0.158675740833291
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/867	149/9376	0.943529721402971	PLCG2/PIP5K1C/FCER1G/EGFR/PIK3R1/PTK2B/AGPAT4/SPHK2/AGPAT1/HRAS/SHC1/DNM2/AGPAT2	-0.221788349676543
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/867	104/9376	0.935853074261379	PLD3/LPIN1/LPCAT1/SGMS1/AGPAT4/PLA2G12A/AGPAT1/PLA2G15/AGPAT2	-0.209972167211281
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/867	59/9376	0.916466287412273	NME4/NT5C3B/AK9/NT5C/ENTPD6	-0.2054497735373
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/867	83/9376	0.912049582412696	CBX3/LCOR/L3MBTL2/JARID2/HDAC2/KDM2A/SFMBT2	-0.256894560474687
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/867	83/9376	0.912049582412696	CCL5/CCL4/POLR2L/IL1B/IKBKB/RELA/NFKBIB	-0.256894560474687
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/867	36/9376	0.901191849288735	DCXR/FGGY/AKR1A1	-0.189594837851778
NA	NA	hsa03272	Virion - Hepatitis viruses	4/867	48/9376	0.901191849288735	CLDN5/EGFR/CHMP1A/CD9	-0.219066034217142
Genetic Information Processing	Transcription	hsa03040	Spliceosome	21/867	243/9376	0.934569325188318	RBM25/SYF2/HNRNPM/SNRPD2/CCDC12/RBMX2/SNRPA/U2AF2/PRPF3/PRPF6/RBM22/DDX42/EFTUD2/PRPF4/SART1/DHX16/TCERG1/CRNKL1/SF3A2/GPKOW/PQBP1	-0.329863097237706
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/867	37/9376	0.876835312821472	MIF/MAOA/IL4I1	-0.239603306833352
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/867	12/9376	0.901191849288735	VKORC1L1	-0.109322263914075
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/867	12/9376	0.901191849288735	FCGR2B	-0.109322263914075
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/867	122/9376	0.886418212415149	EEF2/IRS2/PIK3R1/CREB3L1/ULK1/ADIPOR2/PPP2R3C/CCND1/CPT1A/CAMKK2	-0.403069366077343
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/867	75/9376	0.865144175317186	GPX7/GPX3/CREB3L1/ATF4/PRKACB/ITPR1	-0.374275538447545
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/867	63/9376	0.858277951703557	HPGD/PTGDS/GPX4/PLA2G12A/PTGES2	-0.360262301290264
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/867	158/9376	0.889784357525587	YWHAE/TGFB1/MCM3/ORC3/CDKN1A/YWHAH/ORC2/CDKN2C/ATRX/CCND1/HDAC2/YWHAZ/ANAPC11	-0.445973807908154
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/867	27/9376	0.801059421589987	OXCT2/EHHADH	-0.330429340516777
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/867	125/9376	0.865144175317186	CTSD/FCER1G/PIK3R1/RAC1/SGMS1/SPHK2/PRKCE/PPP2R3C/HRAS/RELA	-0.484491654202842
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/867	28/9376	0.772450156533201	MECR/TECR	-0.384903739094147
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/867	28/9376	0.772450156533201	TCIRG1/ATP6V1E1	-0.384903739094147
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/867	103/9376	0.839945801278821	UPF2/SRRM1/PABPC4/TARDBP/DDX19B/PPP2R3C/CPSF1/DDX19A	-0.52135252242512
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/867	115/9376	0.846336693245073	PIK3R1/GNAO1/CREB3L1/ATF4/PRKACB/HRAS/ITPR1/JAK2/GNB4	-0.529231978084949
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/867	54/9376	0.801059421589987	DNMT1/MPST/IL4I1/SDSL	-0.467973899882314
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/867	54/9376	0.801059421589987	RPA1/TOP3B/CENPX/BRCA1	-0.467973899882314
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/867	29/9376	0.745813944238953	LATS1/DCHS1	-0.437593159947277
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/867	93/9376	0.813979734841438	EGFR/PTK2B/ATF4/PRKACB/MAP2K7/HRAS/ITPR1	-0.575457802919346
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/867	154/9376	0.84267289803622	DHRS3/QPRT/NME4/AKR1A1/SPR/LIAS/PMM1/GMPPA/AK9/FLAD1/VKORC1L1/NADSYN1	-0.628358174646532
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/867	166/9376	0.846903183668932	MYL9/ATP2B4/IRS2/MEF2A/PPP3CA/MYLK3/CREB3L1/EDNRA/VASP/ATF4/PRKCE/SLC25A4/ITPR1	-0.635252398697845
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/867	30/9376	0.720953479430988	IDH1/CS	-0.488630166887339
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/867	44/9376	0.737338785781692	MAN1B1/MAN1A2/HEXB	-0.557430651793628
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/867	31/9376	0.697696915578376	PGD/H6PD	-0.538133089648153
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/867	31/9376	0.697696915578376	ALDH7A1/AKR1A1	-0.538133089648153
NA	NA	hsa04981	Folate transport and metabolism	2/867	31/9376	0.697696915578376	FOLR2/SLCO2B1	-0.538133089648153
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/867	133/9376	0.813105427929686	MAOA/GNAO1/PPP3CA/CREB3L1/ATF4/PRKACB/GSK3A/PPP2R3C/ITPR1/GNB4	-0.692902227592106
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/867	59/9376	0.733173029929818	IRS2/PNPLA2/PIK3R1/PRKACB	-0.656256484673674
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/867	17/9376	0.636135423027342	PCDH20	-0.479297805193026
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/867	32/9376	0.675893886966551	GALT/HK1	-0.586207974138233
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/867	85/9376	0.763362507632811	GUK1/NME4/NT5C3B/AK9/NT5C/ENTPD6	-0.69954831108599
NA	NA	hsa04081	Hormone signaling	17/867	219/9376	0.83946638015937	NPR3/PRLR/TRH/PRL/IRS2/SLC40A1/RAMP1/PIK3R1/GNAO1/DIO2/PRKACB/ADIPOR2/HAMP/SLC16A10/JAK2/RAMP2/GNB4	-0.767303844260899
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/867	46/9376	0.705280577704227	BLVRB/FTL/HMOX1	-0.639591636730752
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/867	73/9376	0.740705629552385	EGFR/PIK3R1/CDKN1A/HRAS/CCND1	-0.709902871027546
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/867	60/9376	0.720953479430988	LYN/GNAO1/HRAS/ITPR1	-0.692139160789155
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/867	18/9376	0.60079456619249	MECR	-0.541124380111681
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/867	138/9376	0.783645086338031	CPEB4/YWHAE/PPP3CA/FBXW11/YWHAH/RPS6KA2/PRKACB/YWHAZ/ANAPC11/ITPR1	-0.817284480840421
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/867	75/9376	0.720953479430988	CD82/IGFBP3/CDKN1A/CCND1/SHISA5	-0.7744588488004
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/867	217/9376	0.797367903518144	GSTA1/VEGFA/EGFR/PIK3R1/CREB3L1/ATF4/RPS6KA2/PRKACB/HRAS/RELA/CCND1/KPNA6/RXRB/PPARA/JAK2/PAQR7	-0.963984387685075
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/867	65/9376	0.665495519474758	SPP1/PIK3R1/HRAS/ITPR1	-0.863806324364758
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/867	66/9376	0.655412254028171	CYP11A1/HSD17B11/CYP3A5/HSD3B1	-0.896711793578725
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/867	93/9376	0.697696915578376	LYZ/ATP2B4/CST2/VAMP2/PRKACB/ITPR1	-0.935181275162282
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/867	52/9376	0.623902049507586	CYP11A1/PRKACB/HSD3B1	-0.868075364359646
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/867	94/9376	0.69027460796584	S100A9/IL1B/IKBKB/TRAF3/RELA/IL17RC	-0.963331765443176
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/867	23/9376	0.470187051802818	CTSA	-0.812020407272369
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/867	24/9376	0.450595924644367	HS6ST1	-0.860203437019006
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/867	99/9376	0.655412254028171	TPM1/TPM3/TGFB1/ITGB4/EDN1/DTNA	-1.10019476305414
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/867	86/9376	0.628738499503769	CREB3L1/VAMP2/ATF4/PRKACB/SLC2A1	-1.10402068217126
NA	NA	hsa04382	Cornified envelope formation	15/867	217/9376	0.74753240954826	KRT8/KRT7/KRT18/CLDN5/COL17A1/PLEC/S100A9/KRT19/DSP/PRSS8/ITGB4/PPP2R3C/SLC27A1/S100A10/LAMC2	-1.20106745089981
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/867	73/9376	0.592564503641908	GSTA1/MAOA/CYP3A5/GSTP1	-1.11548749833571
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/867	115/9376	0.658261872523946	MAOA/GNAO1/HTR2A/PRKACB/HRAS/ITPR1/GNB4	-1.1769806924671
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/867	233/9376	0.742613026023335	FN1/MYL9/TPM1/PLEC/SYNE2/TLN1/DSP/TPM3/FBN2/PDLIM4/BGN/ITGB4/FBLN1/DTNA/ANKRD1/ANK3	-1.26991920118641
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/867	44/9376	0.491559190521128	TAF1/TAF15	-1.07903442337218
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/867	89/9376	0.607545066936226	FN1/SPP1/VWF/ITGB4/LAMC2	-1.18741627750933
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/867	323/9376	0.770058669980467	TIMP3/PLCG2/TPM1/IRS2/EZR/RDX/ZEB1/VEGFA/EGFR/PIK3R1/HMOX1/WNT3/DNMT1/CDKN1A/IKBKB/APC/PRKCE/HRAS/CCND1/SHC1/HDAC2/BRCA1/STMN1	-1.34238770307747
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/867	76/9376	0.56917379955078	EZR/MYLK3/PRKACB/ITPR1	-1.2037141166331
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/867	105/9376	0.617960125226561	TPM1/TPM3/TGFB1/PRKACB/ITGB4/DTNA	-1.25659688310031
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/867	91/9376	0.594192428102463	GNAO1/PDE10A/PRKACB/PDE7A/GNB4	-1.24166892837394
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/867	28/9376	0.386225078266601	SPR	-1.03820885454431
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/867	48/9376	0.450595924644367	PIK3R1/HK1	-1.21807534200893
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/867	30/9376	0.360476739715494	PLA2G12A	-1.11985039900854
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/867	32/9376	0.337946943483276	BIRC2	-1.19744974076635
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/867	128/9376	0.591407151095732	GUK1/NME4/PDE10A/AK9/PDE7A/NT5C/ENTPD6	-1.48568849703844
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/867	70/9376	0.463470093919921	GSTA1/CYP3A5/GSTP1	-1.43819361222369
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/867	34/9376	0.318067711513671	FBXW11	-1.27150100063249
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/867	226/9376	0.669912525134989	FXYD1/MYL9/ATP2B4/PIK3R1/RAC1/PDE10A/CREB3L1/EDNRA/PRKACB/EDN1/RELA/ACOX3/TIAM1/PPARA	-1.60335113305718
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/867	86/9376	0.502990799603015	TCF7L2/DSP/ITGB4/DTNA	-1.47795673867143
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/867	103/9376	0.524966125799263	SLC7A8/COL17A1/COL14A1/COL26A1/SLC16A10	-1.54735152548772
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/867	89/9376	0.486036053548981	GNAO1/GABARAPL1/PRKACB/GNB4	-1.55505538254937
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/867	191/9376	0.622813215215251	MAOA/GNAO1/CREB3L1/ATF4/PRKACB/SLC29A1/HRAS/SHC1/HDAC2/GNB4/CAMKK2	-1.68108431735168
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/867	37/9376	0.292278437607157	IL4I1	-1.37679419768099
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/867	38/9376	0.28458689977539	PIK3R1	-1.41051489629283
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/867	39/9376	0.277289799781149	ALDH7A1	-1.44360618319936
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/867	110/9376	0.491559190521128	CPEB4/PIK3R1/RPS6KA2/PRKACB/ANAPC11	-1.71216857284527
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/867	79/9376	0.410669703473348	GSTA1/CYP3A5/GSTP1	-1.67902368813129
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/867	97/9376	0.445950605833601	GNAO1/PRKACB/ITPR1/GNB4	-1.75081270395791
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/867	82/9376	0.395645202126762	GSTA1/NME4/GSTP1	-1.75450048045854
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/867	116/9376	0.466133715149346	GNAO1/PPP3CA/PRKACB/ITPR1/GNB4	-1.84676621622002
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/867	45/9376	0.240317826476996	ABCB8	-1.63053461425859
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/867	102/9376	0.424090282018228	ATP2B4/RAC1/PLA2G12A/ITPR1	-1.86671007798332
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/867	68/9376	0.318067711513671	DHRS3/CYP3A5	-1.80145512563299
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/867	154/9376	0.491559190521128	TPM1/ATP2B4/TPM3/CREB3L1/ATF4/PRKACB/PPP2R3C	-2.03069232809933
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/867	90/9376	0.240317826476996	PRKACB/SLC2A1	-2.31150467249911
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/867	370/9376	0.555329031453599	NPW/PRLR/TRH/PRL/RXFP1/ADM/LYNX1/C5AR1/PGRMC2/HTR2A/EDNRA/F2RL3/APLN/LYPD6/EDN1/FPR3/PTGER4/PTAFR/TAC3	-2.78566951944907
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/867	183/9376	0.35456728496606	MDN1/FCF1/GNL3L/GNL2/DROSHA/DKC1	-2.81451660095564
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/867	86/9376	0.125747699900754	PRKACB	-2.59976490817195
NA	NA	hsa04082	Neuroactive ligand signaling	5/867	199/9376	0.27171613546394	GNAO1/HTR2A/PRKACB/TAC3/GNB4	-3.3146126656329
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/867	449/9376	0.0240853055489194	PRKACB	-6.76453869636316