category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	27/205	238/9376	5.18860422217668	RPL13A/RPS26/C1QB/C1QA/RPS20/RPL28/RPS11/RPL37A/RPS28/RPL18A/RPS8/RPL10/RPL36/RPS15/RPS16/C1QC/RPLP2/RPL31/RPL7/RPS27/RPL27A/RPS2/UBA52/RPL23/MAPK1/RPS14/FGG	9.7855772525047
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/205	99/9376	7.85375708302538	HLA-DRA/C1QB/C1QA/HLA-DRB1/KRT19/HLA-DPA1/HLA-DRB5/KRT18/HLA-DPB1/C1QC/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMB/FCGR3A/HLA-DMA/FGG	10.2493600259022
Human Diseases	Immune disease	hsa05310	Asthma	11/205	32/9376	15.7219512195122	HLA-DRA/HLA-DRB1/PRG2/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/FCER1G/HLA-DMB/HLA-DMA	12.4717722260538
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/205	39/9376	12.9000625390869	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA	11.1335096500616
Genetic Information Processing	Translation	hsa03010	Ribosome	23/205	222/9376	4.73847506042628	RPL13A/RPS26/RPS20/RPL28/RPS11/RPL37A/RPS28/RPL18A/RPS8/RPL10/RPL36/RPS15/RPS16/RPLP2/RPL31/RPL7/RPS27/RPL27A/RPS2/UBA52/RPL23/MRPL24/RPS14	8.42790716205655
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/205	44/9376	11.4341463414634	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA	10.3717041155911
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/205	82/9376	7.80868530636526	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/CTSL/CTSB/HLA-DQA1/HLA-DMB/HLA-DMA	9.25812576186564
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/205	45/9376	11.180054200542	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA	10.2340250213497
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/205	54/9376	9.316711833785	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/HLA-DMA	9.16322195778487
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/205	70/9376	7.8405574912892	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMB/HLA-DMA	8.58841882466484
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/205	50/9376	9.14731707317073	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/CXCR4/HLA-DQA1/HLA-DMB/HLA-DMA	8.63587081216768
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/205	78/9376	7.03639774859287	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMB/MAPK1/FCGR3A/HLA-DMA	8.00358572366111
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/205	95/9376	6.25869062901155	HLA-DRA/FLT1/HLA-DRB1/HLA-DPA1/HLA-DRB5/ACP5/HLA-DPB1/HLA-DQB1/CTSL/HLA-DQA1/ITGB2/HLA-DMB/HLA-DMA	7.70187135252449
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/205	155/9376	4.72119590873328	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CD14/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/CTSL/HLA-DQA1/ITGB2/HLA-DMB/FCGR3A/HLA-DMA/MSR1	6.9841505894109
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/205	66/9376	6.92978566149298	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/SMAD3/HLA-DMB/HLA-DMA	7.22753735370434
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/205	100/9376	5.48839024390244	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CD14/HLA-DPB1/HLA-DQB1/HLA-DQA1/IL1R2/HLA-DMB/HLA-DMA/IL7R	6.74628154382565
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	18/205	224/9376	3.67526132404181	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/TP53/ITGB2/SMAD3/IL1R2/HLA-DMB/MAPK1/ATF6B/HLA-DMA/SLC25A4	6.05879748537502
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/205	181/9376	4.04301307101469	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CD14/CTSD/HLA-DPB1/HLA-DQB1/HLA-DQA1/FCER1G/ITGB2/HLA-DMB/MAPK1/FCGR3A/HLA-DMA	6.18046939930513
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/205	160/9376	4.28780487804878	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/ITGB2/HLA-DMB/PTPRC/HLA-DMA/CD276/ITGB8	6.2711763810725
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/205	205/9376	3.79279000594884	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/CTSD/MT-ND4/GAPDH/MT-CO1/MT-ND5/MT-ATP6/SMAD3/PARP1/NDUFV3/SLC25A4/COX4I1	6.04450982011598
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/205	109/9376	5.03522040724994	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/EBI3/HLA-DPB1/HLA-DQB1/HLA-DQA1/SMAD3/HLA-DMB/MAPK1/HLA-DMA	6.33527032237764
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	19/205	275/9376	3.1599822616408	MT-CO2/C1QB/C1QA/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/C1QC/MT-CO1/MT-ND5/MT-ATP6/PSMD13/NDUFV3/MAPK1/ATF6B/SLC25A4/COX4I1	5.43533349715458
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	13/205	138/9376	4.30851891127607	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/NDUFV3/ATP5ME/COX4I1	5.85380710769084
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/205	143/9376	4.15787139689579	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/C1QC/HLA-DQB1/HLA-DQA1/HLA-DMB/FCGR3A/HLA-DMA	5.68912220233816
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/205	235/9376	3.3086040477426	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/SMARCD3/NDUFV3/ATP5ME/COX4I1/RPS6KB1/CPT1C/SMARCD2	5.35846935650109
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/205	93/9376	4.9179124049305	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/MAPK1/HLA-DMA	5.67683462902492
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/205	180/9376	3.30319783197832	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/TP53/HLA-DMB/HLA-DMA	4.66468408253035
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/205	112/9376	4.08362369337979	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/MAPK1/HLA-DMA	4.90823484286534
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/205	268/9376	2.73054240990171	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/TP53/UBA52/PSMD13/NDUFV3/SLC25A4/COX4I1	4.29726716432724
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/205	173/9376	3.1724799097702	HLA-DRA/HLA-DRB1/HLA-DPA1/TNFSF10/HLA-DRB5/HLA-DPB1/HLA-DQB1/HLA-DQA1/HLA-DMB/MAPK1/HLA-DMA/SLC25A4	4.31189653708602
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	19/205	368/9376	2.36139978791092	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/TP53/PSMD13/NUP50/NDUFV3/PFN2/NUP62/POM121C/COX4I1/SIGMAR1	3.98336057997852
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/205	227/9376	2.82075856881917	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/NDUFV3/MAPK1/SLC25A4/COX4I1	4.15176438713855
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/205	205/9376	2.90036882807852	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-G/HLA-DPB1/HLA-DQB1/HLA-DQA1/TP53/PSMD13/HLA-DMB/HLA-DMA	4.11301888745493
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/205	250/9376	2.56124878048781	PSAP/CTSD/ACP5/CD68/CTSL/CTSB/HEXB/LIPA/NPC2/LAPTM5/AGA/VAMP8/SNAP29/GALNS	3.74072779183074
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/205	308/9376	2.37592651251188	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/TP53/PSMD13/TGM2/NDUFV3/SLC25A4/COX4I1	3.67087049802249
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/205	42/9376	5.44483159117305	FTL/SAT1/FTH1/TP53/GPX4	4.316187271841
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/205	88/9376	3.63813747228381	C1QB/C1QA/C1QC/CLU/ITGB2/F2R/FGG	3.71733651225075
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/205	15/9376	9.14731707317073	ST3GAL5/HEXB/ST3GAL1	4.72121031386082
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/205	388/9376	2.00392255468946	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/GAPDH/MT-CO1/MT-ND5/MT-ATP6/PSMD13/NDUFV3/MAPK1/DVL3/SLC25A4/COX4I1	3.01952593650856
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/205	204/9376	2.46618842659015	FN1/TIMP3/LUM/DCN/CTSL/TP53/NUDT16L1/MAPK1/ESR1/GPC1/RPS6KB1	3.16538886106745
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/205	78/9376	3.51819887429644	C1QB/C1QA/CD14/C1QC/ITGB2/MAPK1	3.33884899555478
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/205	133/9376	2.75107280396112	TNFSF10/TYROBP/HLA-E/HLA-G/FCER1G/ITGB2/MAPK1/FCGR3A	3.04072937045075
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/205	169/9376	2.43567614374369	CTSD/CTSL/CTSB/ATG12/UBA52/MAPK1/VAMP8/SNAP29/RPS6KB1	2.81575579518881
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	18/205	480/9376	1.71512195121951	MT-CO2/MT-CO3/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-ND4/MT-CO1/MT-ND5/MT-ATP6/UBA52/PSMD13/NDUFV3/MAPK1/DVL3/SLC25A4/COX4I1/SIGMAR1	2.40468150330313
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/205	157/9376	2.33052664284605	IGFBP3/HLA-E/HLA-G/TP53/SMAD3/MAPK1/RBL2/SLC25A4	2.5135395094025
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/205	52/9376	3.51819887429644	APOA1/LIPA/NPC2/LRPAP1	2.72235518497053
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/205	362/9376	1.76881821856893	FN1/FLT1/PRL/SPP1/PRLR/TP53/MAPK1/ATF6B/RBL2/F2R/CSH1/ITGB8/IL7R/RPS6KB1	2.23035193141868
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/205	298/9376	1.84174169258471	PRL/TNFSF10/EBI3/CCL18/PRLR/CCL4/CXCR4/IL1RL1/IL1R2/CCL4L2/CSH1/IL7R	2.20773073498793
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/205	137/9376	2.33690582161296	TNFSF10/CTSD/CTSL/CTSB/TP53/PARP1/MAPK1	2.35669204835335
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/205	108/9376	2.54092140921409	IPO7/NUP50/NUP62/POM121C/SNUPN/TMEM33	2.40798388625926
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/205	87/9376	2.62853938884216	MT-CO2/MT-CO3/MT-CYB/MT-CO1/COX4I1	2.28153761903026
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/205	36/9376	3.81138211382114	GALNT6/GALNT15/ST3GAL1	2.52668971051814
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/205	149/9376	2.14869864134883	MT-ND3/MT-ND2/MT-ND1/MT-ND4/MT-ND5/NDUFV3/MAPK1	2.11311534263542
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/205	37/9376	3.70837178642057	HBB/APOA1/HBA2	2.46781828277358
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/205	16/9376	5.71707317073171	HEXB/ST3GAL1	2.82324717332499
NA	NA	hsa04382	Cornified envelope formation	9/205	217/9376	1.89690907047319	KRT7/KRT8/KRT19/S100A9/KRT18/S100A6/S100A4/COL17A1/S100A10	1.99851989284206
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/205	38/9376	3.61078305519897	HEXB/PGM2/PMM2	2.41095925467104
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/205	18/9376	5.08184281842818	HEXB/AGA	2.59152397646973
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/205	227/9376	1.81334479424089	HLA-E/HLA-G/CCL4/CXCR4/TP53/CCL4L2/MAPK1/ATF6B/RPS6KB1	1.85462038131935
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/205	19/9376	4.81437740693196	HEXB/GALNS	2.48820620679416
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/205	100/9376	2.28682926829268	TNFSF10/CCL18/CCL4/CXCR4/CCL4L2	1.93417062042039
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/205	71/9376	2.57670903469598	PRL/PRLR/MAPK1/ESR1	1.99377783596563
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/205	20/9376	4.57365853658537	LIPA/MSMO1	2.39186776851765
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/205	133/9376	2.06330460297084	TNFSF10/ATG12/SMAD3/MAPK1/RBL2/IL7R	1.84642324903625
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/205	201/9376	1.82036160660114	FLT1/IGFBP3/HPGD/CD14/TP53/IL1R2/NUPR1/KDM6A	1.75773961684573
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/205	170/9376	1.88327116212339	TP53/SMAD3/SMARCD3/MAPK1/DVL3/RPS6KB1/SMARCD2	1.73754975218304
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/205	139/9376	1.97424109492894	KRT19/CTSD/KRT18/MAPK1/ESR1/ATF6B	1.73006569665831
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/205	77/9376	2.37592651251188	TP53/SMAD3/MAPK1/RPS6KB1	1.81249451018201
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/205	109/9376	2.09800850302081	SPP1/CD14/CCL4/CCL4L2/MAPK1	1.72386635198615
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/205	110/9376	2.07893569844789	DCN/EMP3/SMAD3/MAPK1/RPS6KB1	1.70176653618551
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/205	50/9376	2.74419512195122	HBB/ITGB2/HBA2	1.84878575475912
NA	NA	hsa04518	Integrin signaling	6/205	154/9376	1.78194488438391	FN1/FLT1/SPP1/ITGB2/ITGB8/FGG	1.46277714537858
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/205	87/9376	2.10283151107373	TP53/SMAD3/MAPK1/RPS6KB1	1.54503575240854
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/205	157/9376	1.74789498213453	C1QB/C1QA/C1QC/LIPA/MAPK1/CPT1C	1.41287181026148
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/205	157/9376	1.74789498213453	MT-CO2/MT-CO3/MT-CYB/MT-CO1/NDUFV3/COX4I1	1.41287181026148
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/205	232/9376	1.5771236333053	FN1/RGCC/CXCR4/ITGB2/MAPK1/F2R/PFN2/ITGB8	1.33075762983402
Organismal Systems	Immune system	hsa04611	Platelet activation	5/205	126/9376	1.81494386372435	FCER1G/MAPK1/F2R/VAMP8/FGG	1.37688073108574
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/205	63/9376	2.17793263646922	HPGD/PTGDS/GPX4	1.40249121639784
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/205	33/9376	2.77191426459719	VAMP8/SNAP29	1.5244413554452
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/205	205/9376	1.56173706127305	HLA-E/HLA-G/TP53/GTF2H1/MAPK1/ATF6B/RBL2	1.21578248846335
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/205	98/9376	1.8667994026879	PTPRC/MAPK1/FCGR3A/RPS6KB1	1.28961085228479
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/205	34/9376	2.69038737446198	PER1/RORB	1.47625026762012
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/205	99/9376	1.84794284306479	TP53/MAPK1/ESR1/RPS6KB1	1.26804486571062
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/205	248/9376	1.47537372147915	TNFSF10/CD14/GAPDH/AHNAK2/PTPRC/MAPK1/S100A10/PFN2	1.1342986549488
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/205	35/9376	2.61351916376307	TPI1/PMM2	1.42976837280865
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/205	67/9376	2.04790680742628	GAPDH/PGM2/TPI1	1.28695324666894
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/205	68/9376	2.01779053084649	CD14/MAPK1/RPS6KB1	1.25932810868978
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/205	103/9376	1.77617807246034	C1QB/C1QA/C1QC/MAPK1	1.18419732016315
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/205	103/9376	1.77617807246034	FN1/CD14/ITGB2/IL1R2	1.18419732016315
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/205	253/9376	1.44621613805071	CD14/TP53/ATG12/UBA52/MAPK1/UBE2V1/PFN2/RPS6KB1	1.07569937992149
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/205	37/9376	2.47224785761371	PGM2/PMM2	1.34148501989644
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/205	37/9376	2.47224785761371	TP53/MAPK1	1.34148501989644
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/205	333/9376	1.37347103200762	FN1/SPP1/HLA-E/HLA-G/TP53/MAPK1/DVL3/RBL2/ITGB8/RPS6KB1	1.03747345857533
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/205	105/9376	1.74234610917538	CD14/CCL4/CCL4L2/PARP1	1.14364705937832
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/205	38/9376	2.40718870346598	PTPRC/IL7R	1.29948546315783
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/205	106/9376	1.72590888173033	TP53/FOLR2/IL1R2/MAPK1	1.12369745623921
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/205	144/9376	1.58807588075881	C1QB/C1QA/CD14/C1QC/CPT1C	1.06321461506681
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/205	110/9376	1.66314855875831	FLT1/GAPDH/MAPK1/RPS6KB1	1.04596041028023
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/205	148/9376	1.54515491100857	TP53/MAPK1/DVL3/ESR1/RPS6KB1	0.999427316665167
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/205	75/9376	1.82946341463415	IGFBP3/CD82/TP53	1.07824453777436
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/205	41/9376	2.23105294467579	TP53/MAPK1	1.18104302888941
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/205	150/9376	1.52455284552846	TP53/SMAD3/MAPK1/DVL3/RPS6KB1	0.968238558422098
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/205	77/9376	1.78194488438391	TP53/SMAD3/MAPK1	1.03004833275826
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/205	44/9376	2.07893569844789	GTF2H1/TAF11	1.07247890319322
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/205	158/9376	1.44736029638777	CDKN1C/TP53/SMAD3/SMC1A/RBL2	0.847855518131532
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/205	14/9376	3.26689895470383	ST3GAL1	1.26901303667406
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/205	46/9376	1.98854718981972	FTL/FTH1	1.00482335745666
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/205	122/9376	1.49956017592963	TP53/THRA/MAPK1/ESR1	0.830342370657536
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/205	122/9376	1.49956017592963	IGFBP3/MAPK1/ATF6B/CSH1	0.830342370657536
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/205	49/9376	1.8667994026879	GALNT6/GALNT15	0.909494080997317
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/205	125/9376	1.46357073170732	CTSD/TP53/FCER1G/MAPK1	0.780065186638807
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/205	16/9376	2.85853658536585	MIF	1.11236522547758
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/205	50/9376	1.82946341463415	AOC1/SAT1	0.879202175129322
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/205	168/9376	1.36120789779326	TNFSF10/FTL/FTH1/PARP1/SLC25A4	0.706290630659675
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/205	168/9376	1.36120789779326	PRL/PRLR/STAM/CSH1/IL7R	0.706290630659675
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/205	89/9376	1.54168265278158	FN1/SPP1/ITGB8	0.767637938064026
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/205	90/9376	1.52455284552846	TP53/ATF6B/RPS6KB1	0.747567451602234
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/205	212/9376	1.29443166129775	FLT1/ITGB2/MAPK1/FYB1/F2R/PFN2	0.648282236381569
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/205	55/9376	1.66314855875831	PSAP/HEXB	0.73742039168218
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/205	56/9376	1.63344947735192	CD14/ITGB2	0.710807925408878
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/205	178/9376	1.28473554398465	NOTUM/TP53/SMAD3/DVL3/TLE4	0.573402001743349
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/205	140/9376	1.30675958188153	SPP1/SMAD3/MAPK1/RPS6KB1	0.546731900742471
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/205	59/9376	1.55039272426623	TP53/MAPK1	0.634037382400243
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/205	21/9376	2.17793263646922	PANK2	0.807908966646118
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/205	142/9376	1.28835451734799	TYROBP/ACP5/MAPK1/FCGR3A	0.517642848662926
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/205	142/9376	1.28835451734799	CTSL/TP53/IL1R2/GPC1	0.517642848662926
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/205	101/9376	1.35851243660951	FN1/SMAD3/MAPK1	0.541579448248056
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/205	22/9376	2.07893569844789	AOC1	0.757464776834608
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/205	144/9376	1.27046070460705	SMARCAD1/SMAD3/MAPK1/DVL3	0.488980730800312
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/205	61/9376	1.49956017592963	FTL/FTH1	0.585215095016623
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/205	62/9376	1.47537372147915	DVL3/TLE4	0.561457800945558
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/205	63/9376	1.45195509097948	TP53/DVL3	0.538114851121685
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/205	105/9376	1.30675958188153	TP53/UBA52/CCZ1	0.472589119035924
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/205	193/9376	1.18488563123973	CCL18/CCL4/CXCR4/CCL4L2/MAPK1	0.3880107380969
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/205	65/9376	1.40727954971857	SPP1/MAPK1	0.492612401379648
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/205	195/9376	1.17273295809881	ITGB2/MAPK1/FCGR3A/SLC25A4/FGG	0.364419614597157
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/205	66/9376	1.3859571322986	HSD11B1/STS	0.470425028805235
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/205	196/9376	1.16674962667994	HLA-E/HLA-G/TP53/UBA52/MAPK1	0.352716508956832
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/205	26/9376	1.75909943714822	APOA1	0.579473740174976
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/205	69/9376	1.32569812654648	FCER1G/MAPK1	0.405965540383638
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/205	69/9376	1.32569812654648	CTSB/EDNRA	0.405965540383638
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/205	203/9376	1.12651688093236	FN1/FLT1/SPP1/MAPK1/ITGB8	0.272455149575988
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/205	71/9376	1.28835451734799	TP53/MAPK1	0.364629638657359
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/205	250/9376	1.09767804878049	HLA-E/HLA-G/CXCR4/FOLR2/SMAD3/STAM	0.234035085433858
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/205	116/9376	1.18284272497897	THY1/CXCR4/ITGB2	0.296247987275814
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/205	117/9376	1.17273295809881	SMARCD3/UCHL5/SMARCD2	0.281086715835643
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/205	73/9376	1.25305713331106	TP53/MAPK1	0.324505995793847
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/205	73/9376	1.25305713331106	TP53/MAPK1	0.324505995793847
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/205	163/9376	1.12237019302708	TP53/SMAD3/MAPK1/ATF6B	0.235625958231634
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/205	254/9376	1.08039178029576	FLT1/SLN/CXCR4/EDNRA/F2R/SLC25A4	0.194194843001325
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/205	119/9376	1.15302316048371	MAPK1/ATF6B/BAG4	0.251159574317332
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/205	30/9376	1.52455284552846	ACLY	0.430220606618804
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/205	30/9376	1.52455284552846	FOLR2	0.430220606618804
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/205	75/9376	1.21964227642276	GAPDH/TPI1	0.285519627073161
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/205	75/9376	1.21964227642276	TP53/MAPK1	0.285519627073161
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/205	166/9376	1.10208639435792	EDNRA/MAPK1/ATF6B/SLC25A4	0.198402123427062
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/205	31/9376	1.47537372147915	PGM2	0.396351573302109
NA	NA	hsa04981	Folate transport and metabolism	1/205	31/9376	1.47537372147915	FOLR2	0.396351573302109
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/205	76/9376	1.20359435173299	APOA1/CPT1C	0.266431315542708
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/205	76/9376	1.20359435173299	TP53/MAPK1	0.266431315542708
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/205	214/9376	1.0686118076134	HLA-E/HLA-G/CXCR4/MAPK1/RPS6KB1	0.151797572373075
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/205	32/9376	1.42926829268293	PGM2	0.363656711694079
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/205	32/9376	1.42926829268293	ATG12	0.363656711694079
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/205	216/9376	1.05871725383921	TNFSF10/CD14/APOA1/TP53/MAPK1	0.130526621338046
NA	NA	hsa04081	Hormone signaling	5/205	219/9376	1.04421427775922	PRL/PRLR/THRA/ESR1/CSH1	0.0989833635646478
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/205	80/9376	1.14341463414634	MAPK1/RPS6KB1	0.192594831133054
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/205	83/9376	1.10208639435792	RYBP/CBX4	0.139663578232663
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/205	83/9376	1.10208639435792	CCL4/CCL4L2	0.139663578232663
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/205	36/9376	1.27046070460705	PGM2	0.243072713620311
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/205	37/9376	1.23612392880686	MIF	0.2151517570193
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/205	370/9376	0.988899143045485	PRL/NPW/TAC3/PRLR/EDNRA/THRA/F2R/CSH1	-0.032572089473463
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/205	86/9376	1.06364152013613	MAPK1/RPS6KB1	0.088641303780401
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/205	38/9376	1.20359435173299	MAPK1	0.188011671644619
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/205	138/9376	0.994273594909862	FN1/MAPK1/FYB1	-0.0101318057164246
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/205	90/9376	1.01636856368564	MAPK1/RPS6KB1	0.0233276886116837
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/205	91/9376	1.00519967837041	IFITM1/MAPK1	0.00745178721240757
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/205	42/9376	1.08896631823461	AOC1	0.0863914149524486
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/205	93/9376	0.9835824809861	SMAD3/MAPK1	-0.0237880613010884
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/205	93/9376	0.9835824809861	FN1/TP53	-0.0237880613010884
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/205	94/9376	0.973118837571354	S100A9/MAPK1	-0.0391602460475321
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/205	43/9376	1.06364152013613	CPT1C	0.062534309895372
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/205	43/9376	1.06364152013613	APOA1	0.062534309895372
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/205	243/9376	0.941082003412627	PRPF18/SNRNP27/U2AF2/SNRPA/PRPF31	-0.139122893274338
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/205	44/9376	1.03946784922395	HEXB	0.0392316573712276
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/205	44/9376	1.03946784922395	PARP1	0.0392316573712276
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/205	97/9376	0.943022378677395	PER1/MAPK1	-0.0843322750066573
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/205	149/9376	0.920870846292355	FCER1G/MAPK1/F2R	-0.145563877879266
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/205	46/9376	0.994273594909862	PSMD13	-0.00582068883315372
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/205	200/9376	0.914731707317073	TNFSF10/GAPDH/MAPK1/F2R	-0.182234283940821
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/205	99/9376	0.923971421532397	MAPK1/RPS6KB1	-0.113695928165
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/205	47/9376	0.973118837571354	MAPK1	-0.0276206344092885
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/205	101/9376	0.905674957739676	MAPK1/DVL3	-0.142490187582979
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/205	154/9376	0.890972442191954	PANK2/DHRS3/PMM2	-0.203956855480558
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/205	49/9376	0.933399701343952	ATF6B	-0.06988073276527
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/205	103/9376	0.888089036230168	SLC7A8/COL17A1	-0.170740024867016
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/205	155/9376	0.88522423288749	MAPK1/DVL3/ATF6B	-0.215417640239693
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/205	157/9376	0.873947491067267	ITGB2/SMAD3/DVL3	-0.238129738450037
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/205	105/9376	0.871173054587689	FCER1G/MAPK1	-0.198468821306469
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/205	158/9376	0.868416177832664	MAPK1/DVL3/RPS6KB1	-0.249383037838274
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/205	53/9376	0.862954440865163	ESR1	-0.1495819814319
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/205	217/9376	0.843070697988086	MAPK1/ESR1/ATF6B/RPS6KB1	-0.349674612695316
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/205	57/9376	0.802396234488661	CPT1C	-0.223718660400815
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/205	115/9376	0.79541887592789	MAPK1/ATF6B	-0.330019620533427
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/205	116/9376	0.788561816652649	GAPDH/TPI1	-0.342579319232474
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/205	59/9376	0.775196362133113	NT5C3A	-0.258967649503719
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/205	59/9376	0.775196362133113	GPX4	-0.258967649503719
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/205	60/9376	0.762276422764228	MAPK1	-0.276176908666086
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/205	60/9376	0.762276422764228	MAPK1	-0.276176908666086
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/205	120/9376	0.762276422764228	TP53/MAPK1	-0.39183698752636
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/205	62/9376	0.737686860739575	RPS6KB1	-0.309814681951752
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/205	122/9376	0.749780087964814	RPS6KB1/CPT1C	-0.415902237519999
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/205	122/9376	0.749780087964814	PTPRC/MAPK1	-0.415902237519999
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/205	63/9376	0.725977545489741	SETD1B	-0.32626151415447
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/205	63/9376	0.725977545489741	GTF2H1	-0.32626151415447
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/205	65/9376	0.703639774859287	ATF6B	-0.358453357849315
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/205	184/9376	0.745705196182397	CXCR4/SEMA3B/MAPK1	-0.520829544153826
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/205	67/9376	0.682635602475428	MAPK1	-0.389760939500445
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/205	68/9376	0.672596843615495	DHRS3	-0.405101035245288
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/205	187/9376	0.733742011216904	CTSB/ATG12/MAPK1	-0.549849135648348
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/205	130/9376	0.703639774859287	MAPK1/ATF6B	-0.508708353974976
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/205	69/9376	0.662849063273241	ATF6B	-0.42024086435632
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/205	70/9376	0.653379790940767	CPT1C	-0.435186683583086
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/205	70/9376	0.653379790940767	HSD11B1	-0.435186683583086
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/205	70/9376	0.653379790940767	MAPK1	-0.435186683583086
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/205	134/9376	0.682635602475428	EDNRA/MAPK1	-0.553199583368608
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/205	72/9376	0.635230352303523	ATG12	-0.464519888465275
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/205	73/9376	0.626528566655529	CXCR4	-0.478918407840457
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/205	138/9376	0.662849063273241	SMC1A/MAPK1	-0.596525697057151
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/205	138/9376	0.662849063273241	MAPK1/RPS6KB1	-0.596525697057151
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/205	75/9376	0.609821138211382	ATF6B	-0.507205283628041
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/205	142/9376	0.644177258673995	UBA52/UBA6	-0.638759188283368
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/205	78/9376	0.586366479049406	TPI1	-0.548431611200499
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/205	78/9376	0.586366479049406	FN1	-0.548431611200499
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/205	79/9376	0.57894411855511	HSD11B1	-0.561870318132068
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/205	144/9376	0.635230352303523	PSMD13/SLC25A4	-0.659487037732685
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/205	83/9376	0.55104319717896	FAR2	-0.614214205019752
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/205	85/9376	0.538077474892396	NT5C3A	-0.639589897675102
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/205	86/9376	0.531820760068066	ATF6B	-0.652090304281132
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/205	86/9376	0.531820760068066	ITGB8	-0.652090304281132
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/205	154/9376	0.59398162812797	MAPK1/ATF6B	-0.759534855766937
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/205	156/9376	0.586366479049406	TP53/MAPK1	-0.7788732482264
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/205	89/9376	0.513894217593861	MAPK1	-0.688877959393893
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/205	93/9376	0.49179124049305	MAPK1	-0.736365897591839
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/205	93/9376	0.49179124049305	LYZ	-0.736365897591839
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/205	226/9376	0.607122814590978	EDNRA/MAPK1/F2R	-0.893829541847206
NA	NA	hsa04519	Cadherin signaling	6/205	404/9376	0.679256218304757	KRT7/KRT8/KRT19/KRT18/MAPK1/DVL3	-0.985277391648664
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/205	98/9376	0.466699850671976	ATF6B	-0.793435779911521
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/205	233/9376	0.58888307338009	FN1/DCN/ITGB8	-0.950064697054084
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/205	99/9376	0.461985710766199	ITGB8	-0.804566325102811
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/205	300/9376	0.609821138211382	FLT1/CD14/TP53/MAPK1	-1.02690754142062
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/205	103/9376	0.444044518115084	WDR82	-0.848208697382102
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/205	105/9376	0.435586527293844	ITGB8	-0.869526761648862
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/205	107/9376	0.427444723045361	CPT1C	-0.890527000077505
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/205	109/9376	0.419601700604162	RPS6KB1	-0.911221631094697
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/205	110/9376	0.415787139689579	MAPK1	-0.921457967435588
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/205	115/9376	0.397709437963945	MAPK1	-0.971583784357067
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/205	115/9376	0.397709437963945	MAPK1	-0.971583784357067
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/205	116/9376	0.394280908326325	MAPK1	-0.981406625740762
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/205	191/9376	0.478917124249777	MAPK1/ATF6B	-1.08777262864184
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/205	128/9376	0.357317073170732	PGM2	-1.09454106259598
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/205	133/9376	0.34388410049514	ATF6B	-1.1393420545
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/205	136/9376	0.336298421807747	TP53	-1.16562952898176
NA	NA	hsa04517	IgSF CAM signaling	3/205	299/9376	0.458895505343013	ITGB2/MAPK1/FGG	-1.42167324333429
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/205	154/9376	0.296990814063985	MAPK1	-1.31511285605332
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/205	238/9376	0.384341053494568	FLT1/MAPK1	-1.43832595840096
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/205	323/9376	0.424798006493997	TIMP3/TP53/MAPK1	-1.57282210955871
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/205	170/9376	0.269038737446198	MICALL2	-1.43792938688554
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/205	174/9376	0.262853938884216	ATF6B	-1.46737555855003
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/205	183/9376	0.249926695988271	RRP7A	-1.53198617274191
NA	NA	hsa04082	Neuroactive ligand signaling	1/205	199/9376	0.229832087265596	TAC3	-1.6417832296045