category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/189	238/9376	6.67004579609622	RPL13A/RPL37A/C1QB/RPS8/C1QA/RPS28/RPL10/RPS27/RPS26/RPS20/RPS11/RPL18A/RPL28/RPL36/RPL23/PLCG2/RPS14/RPL7/RPS16/RPS29/RPS9/RPLP2/RPL13/RPS15/EGFR/RPL27A/RPL31/RPL8/RPL21/RPS5/CCL2/CYBB	12.7080568913044
Genetic Information Processing	Translation	hsa03010	Ribosome	26/189	222/9376	5.81000047666714	RPL13A/RPL37A/RPS8/RPS28/RPL10/RPS27/RPS26/RPS20/RPS11/RPL18A/RPL28/RPL36/RPL23/RPS14/RPL7/RPS16/RPS29/RPS9/RPLP2/RPL13/RPS15/RPL27A/RPL31/RPL8/RPL21/RPS5	10.4026942631404
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/189	39/9376	12.7201193867861	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB	10.5193847979691
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/189	95/9376	7.31072124756335	FLT1/HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL3/ACP5/CTSL/CCL5/HLA-DPB1/HLA-DQA1/HLA-DMB/VEGFA/CCL2	8.86692623792562
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/189	82/9376	7.86475674280552	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/CTSL/HLA-DPB1/HLA-DQA1/HLA-DMB/TAPBP	8.9548935283417
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/189	44/9376	11.2746512746513	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB	9.79796189158734
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/189	155/9376	5.44092848608978	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/CD14/CYBA/HLA-G/CTSL/ITGB1/HLA-DPB1/HLA-DQA1/DYNC1I2/HLA-DMB/MRC2/CYBB	7.99613835147429
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/189	45/9376	11.0241034685479	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB	9.66757132905531
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/189	54/9376	9.18675289045659	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB	8.65333853605355
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/189	138/9376	5.3922245226593	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/ATP5ME/MT-CO1/MT-ATP8/MT-ND4L/MT-ND6/COX7A1	7.45529407129182
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	18/189	205/9376	4.35586527293844	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/CTSD/MT-CO1/MT-ATP8/MT-ND4L/CYBA/MT-ND6/COX7A1/GAPDH/CYBB	6.96791401694677
Human Diseases	Immune disease	hsa05310	Asthma	8/189	32/9376	12.4021164021164	HLA-DRA/PRG2/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DMB	9.26667062472936
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/189	70/9376	7.08692365835223	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB	7.33153703796181
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	19/189	275/9376	3.42749398749399	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/C1QB/C1QA/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/CYBA/MT-ND6/CCL5/COX7A1/CYBB	5.86016217258054
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/189	227/9376	3.71517143323311	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/CYBA/MT-ND6/EGFR/COX7A1/VEGFA	5.93954329825131
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/189	78/9376	6.36005969339303	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CYBA/ITGB1/HLA-DPB1/HLA-DQA1/HLA-DMB/CYBB	6.81791902421962
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/189	99/9376	5.51205173427396	HLA-DRA/C1QB/C1QA/KRT18/KRT19/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DMB	6.473178330695
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/189	100/9376	5.45693121693122	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CD14/HLA-DPB1/CD9/IL1R2/HLA-DQA1/HLA-DMB/CD59	6.42665880915486
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/189	180/9376	3.85843621399177	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/CCL5/HLA-DPB1/HLA-DQA1/HLA-DMB/CCL2/TAPBP	5.55386039308812
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/189	160/9376	4.03068783068783	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/ITGB1/CLDN5/HLA-DPB1/HLA-DQA1/HLA-DMB/GLG1	5.54574179731529
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/189	66/9376	6.01314734648068	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/GATA3/HLA-DQA1/HLA-DMB	5.8618847959871
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/189	50/9376	6.94518518518519	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DMB	6.0455019503122
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/189	235/9376	3.16649780479568	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/ATP5ME/MT-CO1/MT-ATP8/MT-ND4L/MT-ND6/COX7A1	4.82419675365905
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/189	308/9376	2.73812959527245	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/AP2B1/MT-ND6/COX7A1/GPX3/POLR2I	4.44868278192802
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/189	205/9376	3.14590269712221	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/PLCG2/NCOR2/HLA-G/HLA-DPB1/HLA-DQA1/HLA-DMB/TAPBP	4.4556215062797
NA	NA	hsa04518	Integrin signaling	11/189	154/9376	3.54346182917611	FN1/FLT1/COL6A3/ITGB1/EGFR/LIMS2/FLNA/FBN1/VEGFA/TLN1/KDR	4.56459981108543
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/189	109/9376	4.09611183923111	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/EBI3/HLA-DPB1/GATA3/HLA-DQA1/HLA-DMB	4.66326385943171
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/189	110/9376	4.05887445887446	FLT1/PLCG2/TIMP1/EGFR/GAPDH/EGLN3/ELOB/VEGFA/CYBB	4.62851344858649
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/189	93/9376	4.26739489105081	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/GATA3/HLA-DQA1/HLA-DMB	4.54180628330146
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/189	204/9376	2.91814503579209	FN1/TIMP3/IQGAP1/PLCG2/CTSL/ITGB1/EGFR/EZR/FLNA/VEGFA/KDR/RDX	3.97277697300769
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/189	268/9376	2.59148700939746	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/MT-ND6/COX7A1	3.7913044983716
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/189	181/9376	3.01487912537636	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CTSD/CD14/HLA-DPB1/HLA-DQA1/HLA-DMB/MRC2	3.92592591812282
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/189	112/9376	3.54346182917611	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/ITGB1/HLA-DPB1/HLA-DQA1/HLA-DMB	3.88386963995873
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/189	224/9376	2.65759637188209	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-A/HLA-E/HLA-G/HLA-DPB1/IL1R2/HLA-DQA1/HLA-DMB/TLN1	3.60142581305782
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/189	388/9376	2.17356679212349	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/APOE/MT-ATP8/MT-ND4L/MT-ND6/COX7A1/GAPDH/CYBB	3.38627188630159
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/189	116/9376	3.42127349023901	PLCG2/CYBA/ITGB1/CLDN5/THY1/EZR/MYL9/CYBB	3.76354428327684
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/189	143/9376	3.12221112221112	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-DMB	3.66787789428964
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/189	173/9376	2.86754136465119	HLA-DRA/TNFSF10/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL5/HLA-DPB1/HLA-DQA1/HLA-DMB/CCL2	3.55597134414997
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/189	233/9376	2.55494243477076	FN1/FBLN1/TPM1/PLEC/COL6A3/ITGB1/MYL9/DSP/FBN1/BGN/SYNE2/TLN1	3.44728824496975
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/189	203/9376	2.68814345661636	FN1/FLT1/COL6A3/ITGB1/EGFR/MYL9/PIP5K1C/FLNA/VEGFA/TLN1/KDR	3.48763762344725
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/189	368/9376	2.15688980906372	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/MT-ND6/COX7A1/FUS/GPX3	3.24736718752826
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/189	100/9376	3.47259259259259	TNFSF10/CCL4/CCL3/CCL5/CCL21/CXCL14/CCL2	3.56534758855388
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/189	87/9376	3.42127349023901	MT-CO2/MT-CO3/MT-CYB/MT-CO1/TPM1/COX7A1	3.25423321941731
NA	NA	hsa04382	Cornified envelope formation	10/189	217/9376	2.28610440592007	KRT8/KRT7/KRT18/KRT19/PLEC/CLDN5/COL17A1/S100A10/DSP/DST	2.74923424892172
NA	NA	hsa03272	Virion - Hepatitis viruses	4/189	48/9376	4.13403880070547	EGFR/CLDN5/CD9/CD81	3.12219771098699
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	10/189	227/9376	2.18539496072536	HLA-A/HLA-E/CCL4/CCL3/HLA-G/CCL5/EGFR/VEGFA/CCL2/TAPBP	2.59309766174632
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/189	480/9376	1.75696649029982	MT-CO2/MT-ND3/MT-CO3/MT-CYB/MT-ND1/MT-ATP6/MT-ND4/MT-ND2/MT-ND5/MT-CO1/MT-ATP8/MT-ND4L/MT-ND6/COX7A1/FUS/GPX3/CYBB	2.44190952034904
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/189	149/9376	2.33059905543127	MT-ND3/MT-ND1/MT-ND4/MT-ND2/MT-ND5/MT-ND4L/MT-ND6	2.34822532130891
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/189	88/9376	2.81866281866282	SERPINE2/CLU/C1QB/C1QA/CD59	2.45845409169452
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/189	60/9376	3.30723104056437	HSPB1/PLCG2/VEGFA/KDR	2.57147113247437
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/189	15/9376	6.61446208112875	HEXB/ST3GAL5	3.12120534564062
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/189	298/9376	1.83118497212457	TNFSF10/EBI3/CCL4/PRLR/CCL3/CCL5/CCL21/CXCL14/IL32/IL1R2/CCL2	2.09141590992662
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/189	133/9376	2.23797589211123	TNFSF10/HLA-A/HLA-E/TYROBP/PLCG2/HLA-G	2.0623445034346
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/189	101/9376	2.45586463408246	FN1/PLCG2/VEGFA/CCL2/CYBB	2.10986372870747
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/189	103/9376	2.40817794215852	C1QB/C1QA/CCL3/CCL5/CCL2	2.06108404670581
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	9/189	248/9376	1.80030721966206	TNFSF10/CD14/AHNAK2/AHNAK/S100A10/MYL9/FLNA/GAPDH/DYNC1I2	1.83199566442652
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/189	250/9376	1.78590476190476	PSAP/CTSD/HEXB/AP2B1/ACP5/TPP1/CTSL/CTSZ/CD68	1.80646426316031
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/189	250/9376	1.78590476190476	HLA-A/HLA-E/AP2B1/HLA-G/EGFR/EHD2/RAB11FIP1/PIP5K1C/FOLR2	1.80646426316031
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/189	142/9376	2.09613234965348	CYBA/CTSL/IL1R2/VEGFA/CCL2/KDR	1.88773885210943
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/189	216/9376	1.83735057809132	TNFSF10/APOA1/CD14/CYBA/CCL3/CCL5/CCL2/CYBB	1.78573144141901
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/189	78/9376	2.54402387735721	C1QB/C1QA/CD14/ITGB1	1.96397621844753
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/189	80/9376	2.48042328042328	PLCG2/EGFR/VEGFA/KDR	1.90727152112613
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/189	52/9376	2.86202686202686	APOE/APOA1/PLTP	1.93115068908602
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/189	193/9376	1.79927077336404	PLCG2/CCL4/CCL3/CCL5/CCL21/CXCL14/CCL2	1.60919982629863
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/189	232/9376	1.7106367451195	FN1/IQGAP1/ITGB1/EGFR/EZR/MYL9/PIP5K1C/RDX	1.57200247615495
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/189	212/9376	1.63801537386443	FLT1/ITGB1/EGFR/FYB1/VEGFA/TLN1/KDR	1.34767823968351
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/189	138/9376	1.79740817421977	FN1/ITGB1/FYB1/PIP5K1C/CCL2	1.35350831975704
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/189	103/9376	1.92654235372682	FN1/HSPB1/CD14/IL1R2	1.35613661220708
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/189	142/9376	1.74677695804456	FOSB/TYROBP/PLCG2/CYBA/ACP5	1.28608546039762
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/189	105/9376	1.88984630889393	CD14/PLCG2/CCL4/CCL21	1.31515228667846
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/189	70/9376	2.12607709750567	EGLN3/ELOB/VEGFA	1.35632979996964
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/189	71/9376	2.09613234965348	PLCG2/CCL5/EGFR	1.32973059958631
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/189	109/9376	1.82049415076938	CD14/CCL4/CCL3/CCL5	1.23580184400191
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/189	41/9376	2.41992515163247	EGFR/VEGFA	1.30686251559101
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/189	157/9376	1.57988743976005	MT-CO2/MT-CO3/MT-CYB/MT-CO1/COX7A1	1.0509481812376
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/189	201/9376	1.48084971965569	FLT1/HPGD/CD14/NUPR1/FUS/IL1R2	0.988402969560531
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/189	333/9376	1.34076934076934	FN1/HLA-A/HLA-E/HLA-G/COL6A3/ITGB1/EGFR/CHD4/VEGFA	0.908146780264261
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/189	253/9376	1.37256624213146	CD14/PLCG2/CCL5/ITGB1/EGFR/MYL9/TLN1	0.861637529009092
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/189	170/9376	1.45907251789605	ITGB1/CLDN5/EZR/MYL9/RDX	0.866363111295669
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	6/189	214/9376	1.39089155911586	HLA-A/HLA-E/PLCG2/HLA-G/ELOB/TAPBP	0.829655348850721
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/189	89/9376	1.67219546994828	FN1/COL6A3/ITGB1	0.913866050743378
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/189	50/9376	1.98433862433862	CD81/CCL2	1.0009479751843
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/189	16/9376	3.1005291005291	MIF	1.20609204123523
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/189	16/9376	3.1005291005291	HEXB	1.20609204123523
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/189	93/9376	1.60027308414405	IQGAP1/EGFR/MYL9	0.834402989589485
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/189	93/9376	1.60027308414405	LYZ/ATP2B4/CST3	0.834402989589485
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/189	53/9376	1.87201757013078	AP2B1/ATP2B4	0.913092993589011
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/189	137/9376	1.44842235353184	TNFSF10/CTSD/CTSL/CTSZ	0.758341347363872
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/189	55/9376	1.8039442039442	PSAP/HEXB	0.857641289952099
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/189	18/9376	2.75602586713698	HEXB	1.06956042025176
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	9/189	362/9376	1.23335964219942	FN1/FLT1/PRLR/COL6A3/ITGB1/EGFR/YWHAE/VEGFA/KDR	0.649457805494305
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/189	139/9376	1.42758174412851	KRT18/KRT19/CTSD/EGFR	0.728434933198909
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	5/189	184/9376	1.34805613066483	SEMA3B/PLCG2/ITGB1/DPYSL2/MYL9	0.68388467775546
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/189	19/9376	2.61097187412977	HEXB	1.00815225529295
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/189	187/9376	1.32642956172368	CYBA/CCL5/YWHAE/CCL2/CYBB	0.646704438338604
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/189	103/9376	1.44490676529511	COL6A3/COL17A1/COL14A1	0.651189177708352
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/189	21/9376	2.36230788611741	CHPF	0.896381127370945
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/189	61/9376	1.62650706913002	ATP2B4/ATOX1	0.704091571732042
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/189	106/9376	1.40401317759808	EGFR/IL1R2/FOLR2	0.599982078639393
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/189	196/9376	1.26552208184861	HLA-A/HLA-E/PLCG2/HLA-G/VEGFA	0.538811705079352
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/189	22/9376	2.25493025493026	AOC1	0.845204750771481
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/189	63/9376	1.57487192407827	HPGD/PTGDS	0.656638366215751
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/189	23/9376	2.15688980906372	PCYOX1	0.796728088424255
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/189	200/9376	1.24021164021164	TNFSF10/ITGB1/CLDN5/EZR/GAPDH	0.492506567551217
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/189	156/9376	1.27201193867861	EGFR/CLDN5/YWHAE/CD81	0.491376617586724
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/189	157/9376	1.26390995180804	C1QB/C1QA/MFGE8/BSG	0.478292276821738
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/189	205/9376	1.20996257581623	HLA-A/HLA-E/HLA-G/YWHAE/CHD4	0.435953489212386
NA	NA	hsa04517	IgSF CAM signaling	7/189	299/9376	1.16140220488047	IQGAP1/PLCG2/ITGB1/EZR/MYL9/KDR/RDX	0.406821195557477
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/189	300/9376	1.15753086419753	FLT1/HSPB1/CD14/EGFR/FLNA/VEGFA/KDR	0.397748656482349
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/189	254/9376	1.17185351831021	FLT1/PLCG2/EGFR/ATP2B4/VEGFA/KDR	0.39825380534845
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/189	26/9376	1.90801790801791	APOA1	0.664974458452586
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/189	117/9376	1.27201193867861	BRD9/CHD4/BPTF	0.424647465821951
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/189	71/9376	1.39742156643565	SLC16A3/EGFR	0.482116614834033
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/189	27/9376	1.83735057809132	TECR	0.624937101474998
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/189	73/9376	1.35913604406755	MAP1B/SUPT5H	0.44181310754135
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/189	73/9376	1.35913604406755	PLCG2/EGFR	0.44181310754135
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/189	28/9376	1.77173091458806	TECR	0.586563782416276
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/189	76/9376	1.30548593706488	APOA1/PLTP	0.383518419030689
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/189	76/9376	1.30548593706488	PLCG2/EGFR	0.383518419030689
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/189	30/9376	1.65361552028219	FOLR2	0.514280168120156
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/189	77/9376	1.28853157424586	EGFR/VEGFA	0.364628210561418
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/189	31/9376	1.60027308414405	H6PD	0.480142054514005
NA	NA	hsa04981	Folate transport and metabolism	1/189	31/9376	1.60027308414405	FOLR2	0.480142054514005
Organismal Systems	Immune system	hsa04611	Platelet activation	3/189	126/9376	1.1811539430587	PLCG2/ITGB1/TLN1	0.293624222475258
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/189	78/9376	1.27201193867861	PLCG2/PIP5K1C	0.345995283190168
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/189	78/9376	1.27201193867861	FN1/ITGB1	0.345995283190168
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/189	323/9376	1.07510606581814	TIMP3/TPM1/PLCG2/EGFR/EZR/VEGFA/RDX	0.197019719571757
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/189	130/9376	1.14481074481074	EGFR/VEGFA/RXFP1	0.238465304859673
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/189	34/9376	1.45907251789605	POLR2I	0.384618795890491
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/189	83/9376	1.195384713457	CCL4/CCL5	0.25643738645638
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/189	36/9376	1.37801293356849	GALNT6	0.325922357966529
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/189	86/9376	1.1536852467085	PLCG2/EGFR	0.205354029620153
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/189	86/9376	1.1536852467085	ITGB1/DSP	0.205354029620153
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/189	238/9376	1.04219465564003	FLT1/PLCG2/EGFR/VEGFA/KDR	0.0945692686912201
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/189	37/9376	1.34076934076934	MIF	0.297879674451658
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/189	37/9376	1.34076934076934	APOA1	0.297879674451658
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/189	38/9376	1.30548593706488	HEXB	0.270636125943322
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/189	38/9376	1.30548593706488	QPRT	0.270636125943322
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/189	91/9376	1.0902959474388	PLCG2/CD81	0.124144557107525
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/189	144/9376	1.03350970017637	C1QB/C1QA/CD14	0.0581210661599316
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/189	93/9376	1.0668487227627	FN1/ITGB1	0.0929223308470898
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/189	94/9376	1.05549926826523	FOSB/CCL2	0.0775639797001535
NA	NA	hsa04519	Cadherin signaling	8/189	404/9376	0.982345853632982	KRT8/KRT7/KRT18/KRT19/EGFR/YWHAE/DSP/KDR	-0.0520262418061953
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/189	42/9376	1.1811539430587	AOC1	0.16875949631361
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/189	42/9376	1.1811539430587	CYBB	0.16875949631361
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/189	149/9376	0.998828166613401	PLCG2/EGFR/PIP5K1C	-0.00206803756513541
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/189	43/9376	1.1536852467085	APOA1	0.144872333538142
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/189	98/9376	1.01241766547889	PLCG2/PIP5K1C	0.0177237449593365
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/189	98/9376	1.01241766547889	PLCG2/PIP5K1C	0.0177237449593365
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/189	98/9376	1.01241766547889	ATP2B4/CYP11A1	0.0177237449593365
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/189	44/9376	1.12746512746513	HEXB	0.121551420873117
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/189	44/9376	1.12746512746513	DYNC1I2	0.121551420873117
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/189	99/9376	1.00219122441345	EGFR/PIP5K1C	0.00314362228674563
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/189	99/9376	1.00219122441345	TPM1/ITGB1	0.00314362228674563
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/189	154/9376	0.966398680684395	EGFR/EEF2/MYL9	-0.0603022911690064
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	3/189	157/9376	0.947932463856031	HLA-A/HLA-E/HLA-G	-0.0943636275941238
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/189	103/9376	0.96327117686341	FUS/UPF2	-0.053758256790379
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/189	105/9376	0.944923154446964	TPM1/ITGB1	-0.0814010674069633
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/189	49/9376	1.01241766547889	GALNT6	0.0124996165355337
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/189	49/9376	1.01241766547889	FOSB	0.0124996165355337
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/189	50/9376	0.992169312169312	AOC1	-0.0079628198412856
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/189	51/9376	0.972715011930698	PLD3	-0.0280229671777067
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/189	51/9376	0.972715011930698	PLCG2	-0.0280229671777067
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/189	52/9376	0.954008954008954	CYP11A1	-0.0476983667468243
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/189	110/9376	0.901972101972102	EMP3/FBN1	-0.148330194801699
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/189	115/9376	0.862755923625489	EGFR/GATA3	-0.212394501272237
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/189	56/9376	0.885865457294029	CD14	-0.122866317658946
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/189	116/9376	0.855318372559752	GAPDH/H6PD	-0.224888148341386
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/189	174/9376	0.855318372559752	RRBP1/SIL1/SSR4	-0.276297259312232
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/189	57/9376	0.870323958043256	TECR	-0.14084524848573
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/189	119/9376	0.833755724512027	CCL5/CCL2	-0.261766900401084
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/189	59/9376	0.840821450990943	GPX3	-0.175914720143161
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/189	59/9376	0.840821450990943	EGFR	-0.175914720143161
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/189	120/9376	0.826807760141093	PLCG2/YWHAE	-0.273865333058715
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/189	62/9376	0.800136542072026	NCOR2	-0.226459637146592
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/189	63/9376	0.787435962039137	POLR2I	-0.242797911598549
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/189	65/9376	0.763207163207163	CYP11A1	-0.274762056034939
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/189	66/9376	0.751643418310085	CYP11A1	-0.290403925831836
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/189	67/9376	0.740424859827845	GAPDH	-0.305829000588254
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/189	68/9376	0.729536258948024	CD14	-0.321044328407113
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/189	133/9376	0.745991964037077	TNFSF10/EGFR	-0.423152082471477
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/189	194/9376	0.767141220749468	TPM1/MYL9/DYNC1I2	-0.470061323684603
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/189	69/9376	0.718963269687907	PLCG2	-0.336056619661835
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/189	69/9376	0.718963269687907	FOSB	-0.336056619661835
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/189	134/9376	0.740424859827845	ADM/MYL9	-0.434072423789575
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/189	195/9376	0.763207163207163	PLCG2/CYBA/CYBB	-0.479259305984602
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/189	370/9376	0.804461604461604	NPW/PRLR/ADM/TRH/TAC3/RXFP1	-0.550423059678509
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/189	71/9376	0.698710783217826	PRLR	-0.365497369918244
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/189	138/9376	0.718963269687907	CPEB4/YWHAE	-0.477027405703391
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/189	73/9376	0.679568022033775	EGFR	-0.394198940149406
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/189	75/9376	0.661446208112875	GAPDH	-0.422204807319228
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/189	75/9376	0.661446208112875	CD82	-0.422204807319228
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/189	75/9376	0.661446208112875	GPX3	-0.422204807319228
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/189	76/9376	0.652742968532442	EZR	-0.43595940613607
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/189	79/9376	0.627955260866653	AP2B1	-0.476285083251738
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/189	154/9376	0.64426578712293	TPM1/ATP2B4	-0.638415053950811
NA	NA	hsa04081	Hormone signaling	3/189	219/9376	0.679568022033775	NPR3/PRLR/TRH	-0.688194160238122
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/189	155/9376	0.640109233657621	EGFR/CYP11A1	-0.648003310142382
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/189	87/9376	0.570212248373168	EGFR	-0.577642131002992
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/189	89/9376	0.55739848998276	EGFR	-0.601727491623282
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/189	226/9376	0.658519454979632	FXYD1/ATP2B4/MYL9	-0.745314071114726
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/189	90/9376	0.551205173427396	EGFR	-0.613598711768371
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/189	93/9376	0.533424361381351	EGFR	-0.648558327895305
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/189	166/9376	0.597692356728501	ATP2B4/MYL9	-0.750087960317685
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/189	168/9376	0.590576971529352	TNFSF10/CYBB	-0.768022483628484
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/189	168/9376	0.590576971529352	PRLR/EGFR	-0.768022483628484
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/189	169/9376	0.587082433236279	CTSD/CTSL	-0.776921826146687
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/189	170/9376	0.583629007158419	PLCG2/EGFR	-0.785776657824641
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/189	99/9376	0.501095612206723	EGFR	-0.715749123091949
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/189	99/9376	0.501095612206723	PLCG2	-0.715749123091949
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/189	102/9376	0.486357505965349	ATP2B4	-0.748095716886199
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/189	178/9376	0.55739848998276	NOTUM/SFRP1	-0.855078273943142
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/189	104/9376	0.477004477004477	PLD3	-0.769232476271062
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/189	105/9376	0.472461577223482	PLCG2	-0.779677744449677
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/189	108/9376	0.45933764452283	UPF2	-0.810540424338208
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/189	110/9376	0.450986050986051	CPEB4	-0.83073642957144
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/189	122/9376	0.406626767282505	EEF2	-0.946177902475849
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/189	122/9376	0.406626767282505	PLCG2	-0.946177902475849
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/189	122/9376	0.406626767282505	PLCG2	-0.946177902475849
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/189	125/9376	0.396867724867725	CTSD	-0.973650110360586
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/189	217/9376	0.457220881184015	EGFR/VEGFA	-1.16026889899419
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/189	142/9376	0.349355391608913	ELOB	-1.12052810644962
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/189	148/9376	0.335192335192335	EGFR	-1.16923757843511
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/189	150/9376	0.330723104056437	EGFR	-1.1851529981309
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/189	154/9376	0.322132893561465	QPRT	-1.21652781673262
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/189	243/9376	0.408300128464738	RBM25/FUS	-1.34037884576775
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/189	157/9376	0.31597748795201	YWHAE	-1.23967543642585
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/189	158/9376	0.313977630433327	YWHAE	-1.24732076079151
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/189	191/9376	0.259730186431757	FOSB	-1.48250724916601
NA	NA	hsa04082	Neuroactive ligand signaling	1/189	199/9376	0.249288771901837	TAC3	-1.53524879768719