category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	46/468	238/9376	3.87215398980105	RPL13A/RPS26/C1QA/C1QB/RPL28/RPS20/RPL37A/RPS11/RPS2/RPL8/RPL7/CFD/RPS8/RPS28/RPS16/RPL18A/RPS14/RPL23/EGFR/RPLP2/C1QC/RPL10/UBA52/RPLP0/RPL27A/STAT2/RPS15/RPL35/RPS5/RPL36/MAPK14/RPS9/RPL21/RPS27/RPL10A/NFKBIB/PLCG1/RPL11/C5AR1/RPL4/RELA/RPL18/CYBB/PLCG2/IRF3/RPL31	10.2870081286064
Genetic Information Processing	Translation	hsa03010	Ribosome	43/468	222/9376	3.88049588049588	RPL13A/RPS26/RPL28/RPS20/RPL37A/RPS11/RPS2/RPL8/RPL7/RPS8/RPS28/RPS16/RPL18A/RPS14/RPL23/RPLP2/RPL10/UBA52/RPLP0/RPL27A/RPS15/RPL35/RPS5/RPL36/RPS9/RPL21/RPS27/RPL10A/MRPS15/MRPS26/MRPL27/RPL11/RPL4/MRPL1/RPL18/MRPL40/MRPL16/RPL31/MRPS16/MRPL36/MRPS18B/MRPL4/MRPS6	9.95535502210658
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/468	70/9376	4.29304029304029	HLA-DRA/ACTB/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/HLA-G/CAV1/HLA-DQA1/HLA-A/CCND1/ITGB2/HLA-DPB1/HLA-DMA/HLA-DQB1	6.33844901268926
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/468	39/9376	5.65066841989919	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/HLA-G/HLA-DQA1/HLA-A/HLA-DPB1/HLA-DMA/HLA-DQB1	6.67056255530367
Human Diseases	Immune disease	hsa05310	Asthma	10/468	32/9376	6.26068376068376	HLA-DRA/HLA-DRB1/HLA-DPA1/PRG2/HLA-DRB5/HLA-DQA1/FCER1G/HLA-DPB1/HLA-DMA/HLA-DQB1	6.83233622736161
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/468	82/9376	3.90910986032937	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/CTSB/HLA-G/CTSL/HLA-DQA1/HLA-A/HLA-DPB1/PSME3/HLA-DMA/HLA-DQB1/CD4	6.06434883634203
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/468	44/9376	5.00854700854701	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/HLA-G/HLA-DQA1/HLA-A/HLA-DPB1/HLA-DMA/HLA-DQB1	6.10863835520997
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/468	45/9376	4.89724596391263	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/HLA-G/HLA-DQA1/HLA-A/HLA-DPB1/HLA-DMA/HLA-DQB1	6.0064579177917
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/468	93/9376	3.44674202738719	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DQA1/MAPK14/NFKBIB/PPP3CB/PLCG1/GATA3/HLA-DPB1/RELA/MAML1/HLA-DMA/HLA-DQB1/CD4	5.43505497726705
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/468	78/9376	3.59587990357221	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DQA1/MAPK14/NFKBIB/FCGR3A/ITGB2/HLA-DPB1/RELA/CYBB/HLA-DMA/HLA-DQB1	5.27661718152564
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/468	50/9376	4.40752136752137	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DQA1/IL15/CXCR4/LTBR/HLA-DPB1/HLA-DMA/HLA-DQB1	5.53725271821284
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/468	99/9376	3.2378485711819	HLA-DRA/C1QA/C1QB/HLA-DRB1/HLA-DPA1/KRT19/HLA-DRB5/CFD/C1QC/HLA-DQA1/FCGR3A/ITGB2/C5AR1/HLA-DPB1/HLA-DMA/HLA-DQB1	5.13053878747882
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	25/468	205/9376	2.44319366270586	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/CTSD/GAPDH/MAPK14/MT-ND5/SLC2A1/COL1A1/SDHA/RELA/NDUFA6/NDUFS2/CYBB/NDUFV3/NDUFS3/PTPA/AKT2/NDUFA13	4.78863414057619
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	37/468	368/9376	2.01430694908956	MT-CO2/MT-CYB/MT-ND3/MT-CO3/ACTB/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/PSMA7/TNFRSF1B/MAPK14/MT-ND5/ATG14/NUP214/PFN1/GPX3/NUP155/DCTN1/PPP3CB/ACTR1A/SDHA/POM121/NDUFA6/PSMD13/NDUFS2/DCTN2/ULK1/NDUFV3/EIF2AK3/NDUFS3/SEC13/PSMD14/NDUFA13/FIG4/CAT	4.54985526960597
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/468	54/9376	4.08103830326053	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/HLA-G/HLA-DQA1/HLA-A/HLA-DPB1/HLA-DMA/HLA-DQB1	5.20424685748782
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/468	227/9376	2.29466470876162	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/EGFR/MAPK14/MT-ND5/SDHA/ARNT/RELA/NDUFA6/NDUFS2/VEGFA/NDUFV3/PRKD2/NDUFS3/AKR1A1/AKT2/NDUFA13/CBR1/CAT	4.52586801857697
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/468	109/9376	2.94079824355054	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/EBI3/HLA-DQA1/MAPK14/NFKBIB/PPP3CB/PLCG1/GATA3/HLA-DPB1/RELA/HLA-DMA/HLA-DQB1/CD4	4.67135118918697
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	37/468	388/9376	1.91047669398185	MT-CO2/MT-CYB/MT-ND3/MT-CO3/APOE/MT-CO1/MT-ND1/MT-ND2/DKK1/MT-ND4/MT-ATP6/GAPDH/PSMA7/MT-ND5/ATG14/LRP5/PPP3CB/SDHA/WNT4/CSNK1E/RELA/NDUFA6/APH1A/PSMD13/NDUFS2/CYBB/ULK1/NDUFV3/EIF2AK3/NDUFS3/SLC39A7/AKT2/PSMD14/APH1B/NDUFA13/IRS2/CALM3	4.19828217328101
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/468	100/9376	3.0051282051282	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/IL1R2/CD14/CD44/HLA-DQA1/IL7R/HLA-DPB1/HLA-DMA/CD59/CSF1R/HLA-DQB1/CD4	4.62040703680555
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	31/468	308/9376	2.01642801642802	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/TGM2/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/PSMA7/POLR2L/MT-ND5/ATG14/GPX3/DCTN1/ACTR1A/SDHA/NDUFA6/AP2A2/PSMD13/NDUFS2/DCTN2/POLR2J/ULK1/NDUFV3/HIP1/NDUFS3/PSMD14/NDUFA13/CLTB	4.15733182934138
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/468	205/9376	2.24773816968939	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/STAT2/HLA-G/CD44/HLA-DQA1/HLA-A/MAPK14/NFKBIB/CCND1/CCNE2/HLA-DPB1/RELA/PSMD13/PLCG2/IRF3/AKT2/PSMD14/HLA-DMA/HLA-DQB1	4.14009689224393
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/468	95/9376	2.95240665766982	FLT1/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CTSL/HLA-DQA1/CTSK/IL15/ITGB2/HLA-DPB1/VEGFA/HLA-DMA/HLA-DQB1	4.38382447281916
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/468	250/9376	2.08355555555556	EGFR/HLA-C/HLA-G/CAV1/FOLR2/HLA-A/GBF1/CXCR4/ARRB1/AGAP3/ITCH/SPG21/CHMP3/GIT1/AP2A2/BIN1/SNX12/ZFYVE27/RAB11FIP2/PARD3/CHMP4A/GIT2/VPS25/EPN1/CLTB/LDLR	3.9801497818533
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/468	110/9376	2.73193473193473	FLT1/ELOB/EGFR/GAPDH/LTBR/HK1/PLCG1/SLC2A1/EIF4E2/ARNT/RELA/CYBB/VEGFA/PLCG2/AKT2	4.1879373558572
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	41/468	480/9376	1.71125356125356	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/MT-ND1/MT-ND2/DKK1/MT-ND4/MT-ATP6/UBA52/PSMA7/TNFRSF1B/MAPK14/MT-ND5/ATG14/LRP5/GPX3/DCTN1/PPP3CB/PLCG1/ACTR1A/SDHA/WNT4/CSNK1E/RELA/NDUFA6/PSMD13/NDUFS2/CYBB/DCTN2/ULK1/NDUFV3/EIF2AK3/HIP1/NDUFS3/PSMD14/NDUFA13/FIG4/CAT/CALM3	3.66662205183928
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/468	138/9376	2.46797968537099	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/ATP5ME/MT-ND5/SDHA/NDUFA6/NDUFS2/NDUFV3/NDUFS3/NDUFA13	3.98188827630074
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	27/468	275/9376	1.96699300699301	MT-CO2/MT-CYB/MT-ND3/MT-CO3/C1QA/C1QB/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/C1QC/CAV1/PSMA7/MAPK14/MT-ND5/PPP3CB/SDHA/NDUFA6/PSMD13/NDUFS2/CYBB/NDUFV3/EIF2AK3/NDUFS3/PSMD14/NDUFA13	3.73047027399549
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/468	224/9376	2.05708180708181	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/IL1R2/HLA-C/HLA-G/HLA-DQA1/HLA-A/IL15/LTBR/CCND1/PPP3CB/CCNE2/SLC2A1/ITGB2/GPS2/HLA-DPB1/RELA/AKT2/HLA-DMA/HLA-DQB1/CD4	3.67022815510132
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	18/468	157/9376	2.296913277805	MT-CO2/MT-CYB/MT-CO3/MT-CO1/MAPK14/ITCH/SDHA/RELA/NDUFA6/NR1H3/NDUFS2/NDUFV3/EIF2AK3/NDUFS3/AKT2/NDUFA13/IRS2/PRKAB2	3.75610146796625
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	26/468	268/9376	1.94361525704809	MT-CO2/MT-CYB/MT-ND3/MT-CO3/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/UBA52/PSMA7/MT-ND5/PLCG1/SDHA/NDUFA6/PSMD13/NDUFS2/NDUFV3/EIF2AK3/NDUFS3/TXN2/MAOA/SLC39A7/PSMD14/NDUFA13/CALM3	3.5922727250947
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/468	52/9376	3.46745562130178	APOE/PLTP/APOC1/APOA1/LRPAP1/ABCA1/CYP27A1/OSBPL5/LDLR	4.08948246461013
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/468	112/9376	2.5042735042735	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DQA1/MAPK14/NFKBIB/HLA-DPB1/RELA/AKT2/HLA-DMA/HLA-DQB1/LAMA3/LDLR	3.67075166765934
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/468	66/9376	3.03548303548304	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DQA1/GATA3/HLA-DPB1/RELA/HLA-DMA/HLA-DQB1	3.80349697322868
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/468	180/9376	2.11471984805318	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-C/STAT2/HLA-G/HLA-DQA1/HLA-A/HLA-DPB1/RELA/EIF2B1/IRF3/HCFC1/AKT2/HLA-DMA/POU2F1/HLA-DQB1	3.46115433991846
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/468	181/9376	2.10303631298106	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CD14/CTSD/HLA-DQA1/MAPK14/FCER1G/FCGR3A/PPP3CB/ITGB2/HLA-DPB1/RELA/AKT2/HLA-DMA/HLA-DQB1/CALM3	3.43456461514256
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/468	155/9376	2.19729804245933	HLA-DRA/ACTB/HLA-DRB1/HLA-DPA1/HLA-DRB5/CD14/HLA-C/HLA-G/CTSL/HLA-DQA1/HLA-A/FCGR3A/ITGB2/HLA-DPB1/CYBB/HLA-DMA/HLA-DQB1	3.44506619524542
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/468	160/9376	2.12863247863248	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/VCAN/HLA-C/HLA-G/HLA-DQA1/HLA-A/PTPRC/ITGB2/HLA-DPB1/JAM2/PTPRF/HLA-DMA/HLA-DQB1/CD4	3.30034820404736
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	20/468	204/9376	1.96413608178314	TIMP3/FN1/LUM/DCN/ACTB/EGFR/CAV1/CTSL/CD63/CD44/MAPK14/CCND1/PDCD4/PLCG1/COL1A1/WNT4/VEGFA/PLCG2/AKT2/ARHGEF1	3.19109591067285
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	21/468	235/9376	1.79028914348063	MT-CO2/MT-CYB/MT-ND3/MT-CO3/ACTB/MT-CO1/MT-ND1/MT-ND2/MT-ND4/MT-ATP6/MAPK14/ATP5ME/MT-ND5/SDHA/NDUFA6/NDUFS2/NDUFV3/NDUFS3/NDUFA13/SMARCB1/PRKAB2	2.81216988482218
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/468	83/9376	2.41375759448049	CCL4/POLR2L/DNASE2/NFKBIB/POLR3GL/CCL4L2/RELA/IRF3/GSDMD/SAMHD1	2.96520339756355
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/468	88/9376	2.27661227661228	SERPINE2/C1QA/C1QB/CFD/C1QC/ITGB2/C5AR1/F2R/CD59/SERPINB2	2.75776788493137
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/468	78/9376	2.31163708086785	C1QA/C1QB/C1QC/CD14/MAPK14/ITGB2/RELA/IRF3/CALM3	2.66615059784136
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/468	133/9376	1.95822890559733	EGFR/MAPK14/IL7R/CCND1/FBXO25/GABARAP/CSNK1E/SETD7/G6PC3/AKT2/IRS2/PRKAB2/CAT	2.5509801075829
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/468	196/9376	1.73765916623059	RCAN1/UBA52/HLA-C/STAT2/HLA-G/HLA-A/MAPK14/ATG14/CCND1/PPP3CB/PLCG1/RELA/VEGFA/PLCG2/IRF3/AKT2/CALM3	2.39210863627879
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/468	212/9376	1.70101596516691	FLT1/ACTB/EGFR/RASGRP2/MAPK14/PFN1/PLCG1/FYB1/ITGB2/F2R/VEGFA/PRKD2/PARD3/AKT2/MAGI3/CSF1R/APBB1IP/CALM3	2.36631065684265
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/468	70/9376	2.28962148962149	TNFRSF1B/NFKBIB/SLC2A1/RELA/G6PC3/AKT2/IRS2/PRKAB2	2.48226542350849
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/468	173/9376	1.7370683266637	HLA-DRA/ACTB/HLA-DRB1/HLA-DPA1/HLA-DRB5/STAT2/HLA-DQA1/NFKBIB/HLA-DPB1/RELA/IRF3/AKT2/HLA-DMA/HLA-DQB1/KPNA1	2.24276902902731
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/468	101/9376	1.98358297368198	FN1/MAPK14/CCND1/PLCG1/COL1A1/RELA/CYBB/VEGFA/PLCG2/AKT2	2.2778923211479
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/468	60/9376	2.33732193732194	MAPK14/PPP3CB/PLCG1/HSPB1/VEGFA/PLCG2/AKT2	2.38185497352572
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/468	214/9376	1.59150091860372	ELOB/HLA-C/HLA-G/TNFRSF1B/HLA-A/MAPK14/CXCR4/AP1S2/PPP3CB/PLCG1/RELA/PLCG2/IRF3/AKT2/SAMHD1/CD4/CALM3	2.00625266635443
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/468	298/9376	1.47903401594677	IL1RL1/PRL/PRLR/CXCL14/EBI3/IL1R2/CCL4/CCL18/TNFRSF1B/IL15/CXCR4/IL32/CSH1/LTBR/IL7R/CCL4L2/IL13RA1/INHA/OSMR/TNFRSF11B/CSF1R/CD4	1.92618438089158
NA	NA	hsa04518	Integrin signaling	13/468	154/9376	1.69119769119769	FN1/FLT1/ACTB/SPP1/EGFR/COL6A3/LIMS2/CCND1/COL1A1/ITGB2/VEGFA/AKT2/LAMA3	1.98229616528395
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/468	250/9376	1.52259829059829	PSAP/CTSB/CTSD/CTSL/CD63/LITAF/CTSK/DNASE2/AP1S2/DMXL1/AP2A2/VAMP8/LAMTOR2/OSBPL5/AP3B1/PPT1/CD68/CLTB/FIG4	1.91962420538302
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/468	109/9376	1.83799890221909	SPP1/CCL4/CD14/STAT2/CTSK/MAPK14/CCL4L2/RELA/IRF3/AKT2	2.01699851152847
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/468	109/9376	1.83799890221909	SLC2A1/RELA/NR1H3/OGA/G6PC3/PTPA/AKT2/PTPRF/IRS2/PRKAB2	2.01699851152847
Organismal Systems	Immune system	hsa04611	Platelet activation	11/468	126/9376	1.74901641568308	ACTB/RASGRP2/MAPK14/FCER1G/COL1A1/F2R/VAMP8/PLCG2/AKT2/ARHGEF1/APBB1IP	1.94010038873446
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/468	142/9376	1.69302997472012	ACTB/IL1R2/CAV1/CTSL/MAPK14/RELA/VEGFA/TXN2/AKT2/SUMO3/GSTP1/CALM3	1.90730310869775
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/468	143/9376	1.68119060426753	HLA-DRA/C1QA/C1QB/HLA-DRB1/HLA-DPA1/HLA-DRB5/C1QC/HLA-DQA1/FCGR3A/HLA-DPB1/HLA-DMA/HLA-DQB1	1.88141113731045
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/468	42/9376	2.38502238502238	FTL/FTH1/GPX4/NCOA4/CYBB	2.06189241066007
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/468	71/9376	1.97520163717347	PRL/PRLR/MAPK14/CCND1/SOCS5/RELA/AKT2	1.89053128201172
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/468	71/9376	1.97520163717347	EGFR/MAPK14/PLCG1/GIT1/RELA/PLCG2/JAM2	1.89053128201172
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/468	116/9376	1.72708517536104	ACTB/THY1/MYL9/MAPK14/CXCR4/PLCG1/ITGB2/CYBB/PLCG2/JAM2	1.80603952956987
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/468	44/9376	2.27661227661228	TAF6/GTF2E2/TAF12/TAF3/GTF2H5	1.94543376964721
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/468	73/9376	1.92108652382625	MAP1B/CXCR4/CHMP4A/CDK9/SMARCB1/SAMHD1/CD4	1.8107930061296
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/468	216/9376	1.48401392845837	CD14/MAPK14/APOA1/PPP3CB/PLCG1/ABCA1/RELA/CYBB/EIF2AK3/IRF3/AKT2/POU2F1/MIB2/ARHGEF1/LDLR/CALM3	1.64951192203192
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/468	233/9376	1.46172187373904	FN1/DCN/ACTB/FBLN1/MYL9/TPM1/VCAN/COL6A3/ANKRD1/NID2/PDLIM4/TPM2/COL1A1/ZYX/PDLIM1/FHL3/INF2	1.63580868857387
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/468	46/9376	2.17762913415087	PSMA7/PSMD13/PSME3/PSMD14/PSMF1	1.83512265177533
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/468	90/9376	1.78081671415005	EGFR/MAPK14/NFKBIB/PPP3CB/PLCG1/RELA/AKT2/CD4	1.7059821268861
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/468	122/9376	1.64214656017935	ACTB/RCAN1/DIO2/CCND1/PLCG1/SLC2A1/WNT4/PLCG2/NCOR1/AKT2	1.63631830523995
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/468	138/9376	1.59692803171064	FN1/ACTB/MAPK14/PLCG1/FYB1/RELA/IRF3/AKT2/GIT2/ARHGEF1/CD4	1.61916459399994
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/468	76/9376	1.84525416104363	EGFR/CCND1/PLCG1/PLCG2/AKT2/CAMK1/CALM3	1.69578621205484
NA	NA	hsa03272	Virion - Hepatitis viruses	5/468	48/9376	2.08689458689459	EGFR/CD81/CD63/CHMP4A/LDLR	1.7303431433648
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/468	142/9376	1.55194414349344	TYROBP/STAT2/CTSK/MAPK14/FCGR3A/PPP3CB/RELA/PLCG2/AKT2/TNFRSF11B/CSF1R	1.51901767472281
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	14/468	193/9376	1.45325716310172	CXCL14/CCL4/STAT2/CCL18/RASGRP2/CXCR4/ARRB1/NFKBIB/PLCG1/CCL4L2/RELA/PLCG2/PARD3/AKT2	1.45830880887397
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/468	227/9376	1.41210135923792	EGFR/CCL4/HLA-C/HLA-G/HLA-A/MAPK14/CXCR4/CCND1/PPP3CB/CCL4L2/RELA/VEGFA/IRF3/AKT2/ARHGEF1/CALM3	1.44061728844918
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/468	80/9376	1.75299145299145	EGFR/AXL/PLCG1/EIF4E2/VEGFA/PLCG2/AKT2	1.55026321884762
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/468	144/9376	1.5303893637227	C1QA/C1QB/C1QC/CD14/MAPK14/CCND1/C5AR1/RELA/IRF3/AKT2/PRKAB2	1.47009911101765
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/468	195/9376	1.43835196142888	ACTB/MAPK14/FCGR3A/PLCG1/ITGB2/C5AR1/RELA/CYBB/HDAC7/PLCG2/HDAC5/HDAC11/AKT2/GSDMD	1.41779593457174
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	17/468	248/9376	1.37331127653708	ACTB/MYL9/CD14/GAPDH/EXOC4/MAPK14/PFN1/AHNAK2/DCTN1/ACTR1A/PTPRC/RELA/DCTN2/TXN2/AKT2/GSDMD/KPNA1	1.36561284788779
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/468	98/9376	1.63544392115821	MYO10/PLPP1/FCGR3A/PLCG1/PTPRC/BIN1/PLCG2/AKT2	1.44937759574811
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/468	67/9376	1.79410639112132	TPI1/GAPDH/HK1/G6PC3/ADPGK/AKR1A1	1.49514405411916
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/468	68/9376	1.76772247360483	CD14/CCND1/RELA/RUNX1T1/AKT2/CSF1R	1.45629374291087
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/468	149/9376	1.47903401594677	MT-ND3/MT-ND1/MT-ND2/MT-ND4/MAPK14/MT-ND5/NDUFA6/NDUFS2/NDUFV3/NDUFS3/NDUFA13	1.35097616830662
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/468	100/9376	1.60273504273504	CXCL14/CCL4/CCL18/TNFRSF1B/CXCR4/LTBR/CCL4L2/CSF1R	1.38887938719321
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/468	133/9376	1.50632992738256	TYROBP/HLA-C/HLA-G/HLA-A/FCER1G/FCGR3A/PPP3CB/PLCG1/ITGB2/PLCG2	1.34794261066633
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/468	201/9376	1.39541608198325	IGFBP3/FLT1/HPGD/IL1R2/CD14/NUPR1/LYL1/RELA/NCOR1/RUNX1T1/PBX3/WT1/CDK9/CSF1R	1.29887626664838
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/468	168/9376	1.43101343101343	PRL/PRLR/EGFR/STAT2/IL15/CSH1/IL7R/CCND1/SOCS5/IL13RA1/OSMR/AKT2	1.29205573990417
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/468	203/9376	1.38166814028883	FN1/FLT1/ACTB/SPP1/MYL9/EGFR/COL6A3/CAV1/CCND1/COL1A1/ZYX/VEGFA/AKT2/LAMA3	1.26007585975392
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/468	169/9376	1.42254589591868	UBA52/CTSB/CTSD/CTSL/ATG14/GABARAP/VAMP8/WDR45B/ULK1/EIF2AK3/AKT2/IRS2	1.27050573319208
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/468	103/9376	1.55605343954858	FN1/IL1R2/CD14/COL1A1/ITGB2/HSPB1/RELA/LAMA3	1.30059917593629
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/468	205/9376	1.36818845111528	HLA-C/HLA-G/HLA-A/LTBR/CCND1/GTF2E2/CCNE2/RELA/HDAC7/SND1/HDAC5/IRF3/HDAC11/MRPS18B	1.22167927474876
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/468	56/9376	1.78876678876679	DPM2/GANAB/MAN1A2/MGAT1/ALG2	1.35691653321759
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/468	56/9376	1.78876678876679	ARRB1/CSNK1G1/CCND1/CSNK1E/GAS1	1.35691653321759
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/468	154/9376	1.43101343101343	ACTB/MYL9/MYL6/EGFR/RCAN1/EEF2/CCND1/PPP3CB/CAMK1/PRKAB2/CALM3	1.23610984580016
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/468	138/9376	1.45175275610058	PHKB/HK1/TRIP10/EIF4E2/G6PC3/AKT2/PTPRF/IRS2/PRKAB2/CALM3	1.22537731361647
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/468	105/9376	1.52641432641433	UBA52/TOMM70/GABARAP/RELA/ULK1/EIF2AK3/SAMM50/PHB2	1.24330454051419
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/468	105/9376	1.52641432641433	STAT2/MAPK14/FCER1G/PPP3CB/RELA/PLCG2/AKT2/CALM3	1.24330454051419
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/468	57/9376	1.75738491527965	FADS1/HADHA/PPT1/ACAA2/ACAA1	1.31458261216681
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/468	42/9376	1.90801790801791	AOC1/MAOA/HADHA/CAT	1.35177254427935
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/468	106/9376	1.51201419125947	EGFR/IL1R2/FOLR2/CCND1/CCNE2/RELA/AKT2/GSTP1	1.21510420669572
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/468	157/9376	1.40366922532528	IGFBP3/HLA-C/HLA-G/HLA-A/MAPK14/CCND1/PPP3CB/CCNE2/RELA/AKT2/CALM3	1.16910096902026
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/468	28/9376	2.14652014652015	HADHA/PPT1/ACAA2	1.39257891379565
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/468	28/9376	2.14652014652015	QDPR/CBR1/DHFR	1.39257891379565
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/468	90/9376	1.55821462488129	EIF4E2/RELA/ULK1/AKT2/IRS2/PRKAB2/CAT	1.21962575308155
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/468	108/9376	1.48401392845837	NUP214/NUP155/IPO8/POM121/SEC13/KPNA1/UPF2/SUMO3	1.15956523227743
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/468	76/9376	1.58164642375169	PLTP/APOA1/NR1H3/CYP27A1/PLIN2/ACAA1	1.16692473240389
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/468	30/9376	2.0034188034188	FOLR2/RELA/DHFR	1.26167772240403
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/468	16/9376	2.5042735042735	MIF/MAOA	1.38028043986115
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/468	62/9376	1.61566032533774	CRYAB/AKT2/IRS2/PRKAB2/CAT	1.11477534744323
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/468	62/9376	1.61566032533774	ITCH/APH1A/MAML1/CTBP2/APH1B	1.11477534744323
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/468	253/9376	1.26698422350596	ACTB/MYL9/EGFR/CD14/UBA52/CD44/MAPK14/ATG14/NFKBIB/HK1/PFN1/PLCG1/RELA/PLCG2/IRF3/AKT2	0.986723525358701
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/468	63/9376	1.59001492334826	PTGDS/HPGD/GPX4/PTGR1/CBR1	1.07697824412888
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/468	63/9376	1.59001492334826	POLR2L/CETN2/RPA2/POLR2J/GTF2H5	1.07697824412888
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/468	48/9376	1.66951566951567	BCAT1/HADHA/ACAA2/ACAA1	1.06587323378959
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/468	116/9376	1.38166814028883	TPI1/GAPDH/HK1/SDHA/TKT/ADPGK/IDH3G/CAT	0.948042639154024
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/468	50/9376	1.60273504273504	AOC1/P4HA2/SMOX/MAOA	0.979449838688595
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/468	50/9376	1.60273504273504	HBB/CD81/HBA2/ITGB2	0.979449838688595
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/468	34/9376	1.76772247360483	POLR2L/POLR3GL/POLR2J	1.02787958743927
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/468	34/9376	1.76772247360483	RORB/CSNK1E/PRKAB2	1.02787958743927
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/468	137/9376	1.31611454239191	ACTB/CTSB/CTSD/CTSL/CTSK/AIFM1/RELA/EIF2AK3/AKT2	0.854300648365065
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/468	156/9376	1.28424282270436	EGFR/CD81/STAT2/CCND1/RELA/NR1H3/PSME3/IRF3/AKT2/LDLR	0.820549540315292
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/468	35/9376	1.71721611721612	TPI1/HK1/PMM2	0.974329466648735
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/468	157/9376	1.27606293211389	C1QA/C1QB/MFGE8/C1QC/AXL/MAPK14/ABCA1/SLC2A1/ARNT/NR1H3	0.799529469170837
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/468	69/9376	1.45175275610058	MAPK14/FCER1G/PLCG1/PLCG2/AKT2	0.863254716397365
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/468	194/9376	1.23922812582606	ACTB/MYL9/MYL6/TPM1/TPM2/MYO10/DCTN1/MYO1E/ACTR1A/DCTN2/KIF3B/HOOK3	0.771725621561445
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/468	122/9376	1.31371724814348	MAPK14/NFKBIB/PPP3CB/PLCG1/PTPRC/RELA/AKT2/CD4	0.799414506967542
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/468	87/9376	1.38166814028883	MT-CO2/MT-CYB/MT-CO3/MT-CO1/TPM1/TPM2	0.819746392640531
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	21/468	362/9376	1.16220427822638	FN1/FLT1/SPP1/PRL/PRLR/EGFR/COL6A3/CSH1/IL7R/CCND1/CCNE2/EIF4E2/COL1A1/RELA/F2R/VEGFA/G6PC3/OSMR/AKT2/CSF1R/LAMA3	0.721400225497162
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/468	105/9376	1.33561253561254	CCL4/CD14/LTBR/PLCG1/CCL4L2/RELA/PLCG2	0.792661917510439
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/468	70/9376	1.43101343101343	ELOB/SLC2A1/ARNT/VEGFA/AKT2	0.829615313859588
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/468	71/9376	1.41085831226676	EGFR/SLC16A3/HK1/SLC2A1/AKT2	0.796492194236019
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/468	37/9376	1.62439362439362	HK1/PMM2/PGM3	0.872223120902131
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/468	37/9376	1.62439362439362	HBB/APOA1/HBA2	0.872223120902131
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/468	21/9376	1.90801790801791	BCAT1/PPCDC	0.954774091973747
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/468	89/9376	1.35061941803515	FN1/SPP1/COL6A3/CD44/COL1A1/LAMA3	0.76174867182119
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/468	107/9376	1.31064781532071	PHKB/PPP3CB/SLC2A1/G6PC3/AKT2/PRKAB2/CALM3	0.740733885090214
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/468	38/9376	1.58164642375169	HK1/PMM2/PGM3	0.823459769268513
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/468	38/9376	1.58164642375169	IL7R/PTPRC/CD4	0.823459769268513
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/468	73/9376	1.37220465987589	EGFR/CCND1/PLCG1/PLCG2/AKT2	0.731728863160799
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/468	22/9376	1.82128982128982	AOC1/MAOA	0.883949711858828
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/468	91/9376	1.32093547478163	CD81/NFKBIB/PPP3CB/RELA/PLCG2/AKT2	0.705124699107153
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	19/468	333/9376	1.14309180975848	FN1/SPP1/EGFR/COL6A3/HLA-C/STAT2/HLA-G/HLA-A/CCND1/CCNE2/COL1A1/WNT4/RELA/VEGFA/MAML1/IRF3/PARD3/AKT2/LAMA3	0.60939528313436
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/468	184/9376	1.19769602378298	MYL9/SEMA3B/CXCR4/RASA1/PPP3CB/PLCG1/WNT4/PLCG2/FES/PARD3/SEMA4A	0.620755103478801
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/468	93/9376	1.2925282602702	ACTB/MYL9/EGFR/RASIP1/PARD3/PTPRF	0.649805806732563
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/468	93/9376	1.2925282602702	FN1/CCND1/CCNE2/RELA/AKT2/LAMA3	0.649805806732563
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/468	75/9376	1.33561253561254	TPI1/GAPDH/BCAT1/TKT/IDH3G	0.66884031701399
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/468	130/9376	1.23287310979619	EGFR/MAPK14/ARRB1/RXFP1/COL1A1/RELA/VEGFA/AKT2	0.612819441871535
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/468	41/9376	1.46591619762351	EGFR/CCND1/VEGFA	0.685268922685272
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/468	77/9376	1.3009213009213	EGFR/CCND1/RELA/VEGFA/AKT2	0.607713144428984
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/468	59/9376	1.35825003621614	GPX4/GPX3/GSTK1/GSTP1	0.632692463995918
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/468	170/9376	1.17848164906988	ACTB/EGFR/LRP5/CCND1/PLCG1/WNT4/PLCG2/AKT2/SMARCB1/GSTP1	0.538271029238222
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/468	78/9376	1.28424282270436	FN1/ACTB/CAV1/MAD2L2/CLTB	0.577777330893943
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/468	154/9376	1.17082917082917	DHRS3/BCAT1/PMM2/QPRT/PNPO/AK9/AKR1A1/PPCDC/DHFR	0.489923526316364
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/468	43/9376	1.39773404889684	HADHA/ACAA2/ACAA1	0.599148983362804
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/468	43/9376	1.39773404889684	APOA1/PLPP1/ABCA1	0.599148983362804
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/468	98/9376	1.22658294086866	CYP11A1/KCNK3/PRKD2/CAMK1/LDLR/CALM3	0.516810732055117
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/468	117/9376	1.19862663452407	ACTB/BAZ1B/VPS72/GATAD2A/DMAP1/SMARCB1/EP400	0.495526441384914
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/468	155/9376	1.16327543424318	EGFR/CYP11A1/CCND1/CCNE2/KCNK3/WNT4/ARNT/AIP/LDLR	0.469803389864215
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/468	44/9376	1.36596736596737	MAN1A2/MGAT1/ALG2	0.557698907792963
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/468	63/9376	1.27201193867861	PRDM2/SETD7/HADHA/PLOD3	0.496514458376274
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/468	120/9376	1.16866096866097	MAPK14/NFKBIB/PLCG1/RELA/PLCG2/AKT2/CALM3	0.42619858241235
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/468	27/9376	1.48401392845837	FADS1/ACAA1	0.577265525763455
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/468	178/9376	1.12551618169596	NOTUM/DKK1/LRP5/CCND1/PPP3CB/WNT4/CSNK1E/APCDD1/VANGL1/CTBP2	0.387508718680943
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/468	83/9376	1.20687879724024	GSTK1/PEX26/SLC25A17/ACAA1/CAT	0.433905865372945
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/468	122/9376	1.14950259212554	EEF2/CCND1/ULK1/G6PC3/AKT2/IRS2/PRKAB2	0.380962607831339
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/468	122/9376	1.14950259212554	IGFBP3/MAPK14/CSH1/PLCG1/PLCG2/AKT2/IRS2	0.380962607831339
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/468	103/9376	1.16704007966144	COL6A3/SLC7A8/COL17A1/COL1A1/COL14A1/PRCP	0.390703796621363
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/468	103/9376	1.16704007966144	C1QA/C1QB/C1QC/MAPK14/RELA/AKT2	0.390703796621363
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/468	48/9376	1.25213675213675	HK1/G6PC3/AKT2	0.401403324214378
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/468	49/9376	1.22658294086866	GALNT15/C1GALT1/PLOD3	0.364479176774344
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/468	30/9376	1.33561253561254	SDHA/IDH3G	0.421992151332183
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/468	30/9376	1.33561253561254	DPM2/PIGS	0.421992151332183
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/468	187/9376	1.07134695369989	CTSB/STAT2/MAPK14/NFKBIB/GABARAP/RELA/CYBB/IRF3/TXN2/GSDMD	0.225881453069694
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/468	31/9376	1.2925282602702	SMOX/HADHA	0.373918956394442
NA	NA	hsa04981	Folate transport and metabolism	2/468	31/9376	1.2925282602702	FOLR2/DHFR	0.373918956394442
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/468	70/9376	1.14481074481074	HSD11B1/GSTK1/CBR1/GSTP1	0.278731943976621
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/468	149/9376	1.07566110250674	EGFR/FCER1G/PLPP1/AGPAT4/PLCG1/F2R/PLCG2/AKT2	0.213380142018493
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/468	51/9376	1.17848164906988	ACTB/PLCG1/PLCG2	0.292935967125439
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/468	32/9376	1.25213675213675	HK1/G6PC3	0.327463718451937
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/468	72/9376	1.11301044634378	MAPK14/NFKBIB/RELA/IRF3	0.22063197271409
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/468	232/9376	1.03625110521662	FN1/ACTB/MYL9/RGCC/EGFR/CXCR4/PFN1/ITGB2/GIT1/F2R/AKT2/ARHGEF1	0.128149110519777
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/468	33/9376	1.21419321419321	BCAT1/IDH3G	0.282512692355101
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/468	33/9376	1.21419321419321	STX8/VAMP8	0.282512692355101
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/468	115/9376	1.04526198439242	EGFR/ARRB1/LRP5/GATA3/OXSR1/ARHGEF1	0.111936578813696
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/468	136/9376	1.03117144293615	STAT2/NFKBIB/CCND1/CCNE2/RELA/IRF3/AKT2	0.0839283790603028
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/468	55/9376	1.09277389277389	PSAP/PLPP1/UGCG	0.158159153254323
NA	NA	hsa04382	Cornified envelope formation	11/468	217/9376	1.01555791878373	KRT19/S100A4/S100A9/KRT7/S100A6/S100A11/KRT8/COL17A1/S100A8/UGCG/LAMA3	0.0531466381570406
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/468	238/9376	1.01012712777419	FLT1/EGFR/RASGRP2/RASA1/PLCG1/RGL1/RELA/VEGFA/PLCG2/AKT2/CSF1R/CALM3	0.0362716783648879
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/468	56/9376	1.07326007326007	CD14/ITGB2/RELA	0.126029399370055
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/468	15/9376	1.33561253561254	ST3GAL5	0.298154344142554
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/468	77/9376	1.04073704073704	CCND1/RELA/CTBP2/AKT2	0.0822688026578521
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/468	36/9376	1.11301044634378	HK1/G6PC3	0.155709411403683
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/468	36/9376	1.11301044634378	GALNT15/C1GALT1	0.155709411403683
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/468	36/9376	1.11301044634378	MCM7/RPA2	0.155709411403683
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/468	119/9376	1.01012712777419	TNFRSF1B/MAPK14/IL15/ITCH/RELA/AKT2	0.0254825625494786
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/468	78/9376	1.02739425816349	TPI1/PLCG1/PLCG2/FIG4	0.0556840141570878
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/468	78/9376	1.02739425816349	MTREX/EXOSC9/TENT4B/MPHOSPH6	0.0556840141570878
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/468	99/9376	1.01182767849435	EGFR/MAPK14/CCND1/NCOR1/AKT2	0.0271163849344006
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/468	37/9376	1.08292908292908	MIF/MAOA	0.115844654237464
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/468	37/9376	1.08292908292908	CCND1/NCOA4	0.115844654237464
Genetic Information Processing	Transcription	hsa03040	Spliceosome	12/468	243/9376	0.989342618972249	SNRNP27/RBMX/ZMAT2/SNIP1/CTNNBL1/SF3A3/SF3A2/EFTUD2/GPKOW/XAB2/PQBP1/RBMX2	-0.0385802787951163
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/468	79/9376	1.01438926755382	HSD11B1/GSTK1/CBR1/GSTP1	0.0294373884426119
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/468	59/9376	1.0186875271621	EGFR/CCND1/AKT2	0.0330033675113116
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/468	17/9376	1.17848164906988	CYP27A1	0.168819172646774
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/468	144/9376	0.973884140550807	PSMA7/ATG14/PSMD13/ULK1/AKT2/PSMD14/CIC	-0.0723862588236086
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/468	125/9376	0.961641025641026	CTSD/MAPK14/FCER1G/RELA/AKT2/SPTSSA	-0.0989569071302799
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/468	18/9376	1.11301044634378	HCFC1	0.109997238659755
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/468	170/9376	0.942785319255907	ACTB/MYL9/MYL6/CCND1/JAM2/PARD3/SYMPK/PRKAB2	-0.172549980640309
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/468	85/9376	0.942785319255907	DCTD/GUK1/AK9/DGUOK	-0.121451860565852
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/468	86/9376	0.93182269926456	EGFR/PLCG1/PLCG2/AKT2	-0.145579301709583
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/468	65/9376	0.92465483234714	PLPP1/AGPAT4/AKR1A1	-0.139711571960678
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/468	65/9376	0.92465483234714	CYP11A1/KCNK3/LDLR	-0.139711571960678
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/468	65/9376	0.92465483234714	SPP1/ARRB1/AKT2	-0.139711571960678
NA	NA	hsa04517	IgSF CAM signaling	14/468	299/9376	0.938055627018838	ACTB/MYL9/MYL6/MAPK14/CLMP/RASA1/PLCG1/ITGB2/GIT1/PLCG2/JAM2/PARD3/AKT2/PTPRF	-0.249508156976959
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/468	20/9376	1.0017094017094	FDFT1	0.00175401169906951
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/468	20/9376	1.0017094017094	CYB5R1	0.00175401169906951
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/468	300/9376	0.934928774928775	FLT1/EGFR/CD14/RASGRP2/MAPK14/ARRB1/RASA1/PPP3CB/MAP4K4/HSPB1/RELA/VEGFA/AKT2/CSF1R	-0.262555322936983
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/468	174/9376	0.921112093525887	CRYAB/SSR4/NSFL1C/SSR1/GANAB/MAN1A2/EIF2AK3/SEC13	-0.24074784102083
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/468	44/9376	0.910644910644911	NTHL1/POLG2	-0.136168523134163
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/468	44/9376	0.910644910644911	DCTN1/DCTN2	-0.136168523134163
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/468	133/9376	0.903797956429535	MAPK14/ARRB1/PPP3CB/MAOA/AKT2/CALM3	-0.256107385222427
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/468	21/9376	0.954008954008954	CHPF	-0.0483592435647842
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/468	45/9376	0.890408357075024	ABCA1/ABCB7	-0.168903271044681
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/468	134/9376	0.897053195560658	MYL9/RAMP1/MYL6/CALD1/ARHGEF1/CALM3	-0.275106434274341
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/468	200/9376	0.901538461538461	ACTB/GAPDH/MAPK14/MYO10/NFKBIB/MYO1E/RELA/F2R/ARHGEF1	-0.322606692993539
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/468	46/9376	0.871051653660349	FTL/FTH1	-0.20094274539793
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/468	69/9376	0.871051653660349	CTSB/PPP3CB/CALM3	-0.246407501993325
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/468	69/9376	0.871051653660349	PPP3CB/MAOA/CALM3	-0.246407501993325
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/468	158/9376	0.887590609109597	CDKN1C/PDS5A/ORC3/CCND1/CCNE2/MCM7/MAD2L2	-0.326611330389149
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/468	158/9376	0.887590609109597	LRP5/EIF4E2/WNT4/LAMTOR2/ULK1/SEC13/AKT2	-0.326611330389149
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/468	47/9376	0.852518639752682	HK1/IRS2	-0.232320202471
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/468	23/9376	0.871051653660349	RPA2	-0.141913165805092
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/468	23/9376	0.871051653660349	PRCP	-0.141913165805092
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/468	138/9376	0.871051653660349	MAPK14/CPEB4/PPP3CB/CCNE2/MAD2L2/CALM3	-0.349771807917397
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/468	94/9376	0.852518639752682	S100A9/MAPK14/RELA/S100A8	-0.329381148737024
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/468	139/9376	0.864785095000922	KRT19/EGFR/CTSD/AKT2/GREB1/CALM3	-0.368116222039289
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/468	140/9376	0.858608058608059	SPP1/CCND1/HDAC5/AKT2/PRKAB2/CALM3	-0.386335995508823
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/468	49/9376	0.817721960579103	RELA/MAOA	-0.293210731123317
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/468	73/9376	0.823322795925536	GSTK1/MAOA/GSTP1	-0.347335279808004
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/468	73/9376	0.823322795925536	EGFR/CCND1/AKT2	-0.347335279808004
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/468	254/9376	0.867622316441214	FLT1/EGFR/PHKB/CXCR4/PPP3CB/PLCG1/F2R/VEGFA/PLCG2/CAMK1/CALM3	-0.490235844285304
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/468	75/9376	0.801367521367521	IGFBP3/CCND1/CCNE2	-0.395853539068042
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/468	51/9376	0.785654432713256	PLPP1/ENPP2	-0.351798217796653
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/468	99/9376	0.809462142795476	MAPK14/PLCG1/PLCG2/CALM3	-0.436831106206001
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/468	99/9376	0.809462142795476	EGFR/PLPP1/PLCG1/AKT2	-0.436831106206001
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/468	99/9376	0.809462142795476	ACTB/TPM1/TPM2/PRKAB2	-0.436831106206001
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/468	26/9376	0.770545693622617	ACAA1	-0.26853168810121
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/468	26/9376	0.770545693622617	APOA1	-0.26853168810121
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/468	52/9376	0.770545693622617	CYP11A1/LDLR	-0.380290269157723
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/468	168/9376	0.834757834757835	FTL/FTH1/STAT2/AIFM1/CHMP3/CYBB/CHMP4A	-0.495349037205944
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/468	27/9376	0.742006964229186	HADHA	-0.307698759645007
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/468	53/9376	0.756007095629737	AP2A2/CLTB	-0.408277784965558
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/468	54/9376	0.742006964229186	RPA2/CENPX	-0.435781484521994
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/468	79/9376	0.760791950665368	AP2A2/STXBP1/CLTB	-0.489368916139964
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/468	217/9376	0.830911024459412	EGFR/ARRB1/CCND1/ARNT/RELA/VEGFA/AIP/AKT2/KPNA1	-0.57761650027386
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/468	103/9376	0.778026719774292	SSU72/SMG6/SYMPK/UPF2	-0.519191582693564
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/468	150/9376	0.801367521367521	EGFR/LRP5/CCND1/CCNE2/WNT4/AKT2	-0.562092288231345
NA	NA	hsa04081	Hormone signaling	9/468	219/9376	0.823322795925536	PRL/PRLR/RAMP1/DIO2/CSH1/ADRA2C/NPR3/TRH/IRS2	-0.606379385794254
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/468	29/9376	0.690834070144415	CSNK1E	-0.382184409378429
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/468	29/9376	0.690834070144415	CALM3	-0.382184409378429
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/468	31/9376	0.646264130135098	TKT	-0.452156476017031
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/468	31/9376	0.646264130135098	AKR1A1	-0.452156476017031
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/468	31/9376	0.646264130135098	CAT	-0.452156476017031
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/468	31/9376	0.646264130135098	SRP19	-0.452156476017031
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/468	59/9376	0.679125018108069	DCTD/AK9	-0.566685728973295
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/468	59/9376	0.679125018108069	AKT2/IRS2	-0.566685728973295
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/468	157/9376	0.765637759268332	ACTB/CCND1/ITGB2/WNT4/CSNK1E/PARD3	-0.678756530226869
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/468	110/9376	0.728515928515929	DCN/EMP3/FMOD/NCOR1	-0.656467165606328
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/468	110/9376	0.728515928515929	MAPK14/CPEB4/AKT2/MAD2L2	-0.656467165606328
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/468	32/9376	0.626068376068376	HADHA	-0.485645345161771
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/468	32/9376	0.626068376068376	GABARAP	-0.485645345161771
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/468	61/9376	0.656858624071739	FTL/FTH1	-0.616261500173269
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/468	87/9376	0.690834070144415	EGFR/CCND1/AKT2	-0.664026228478701
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/468	163/9376	0.73745477426459	STAT2/MAPK14/CCNE2/RELA/IRF3/AKT2	-0.775025250990643
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/468	36/9376	0.55650522317189	AKR1A1	-0.611061303575798
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/468	166/9376	0.724127278344146	MYL9/PPP3CB/ADRA2C/AKT2/IRS2/CALM3	-0.821961448791111
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/468	142/9376	0.705429156133381	ELOB/UBA52/ITCH/UBE2F/UBE2E2	-0.810694929126872
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/468	66/9376	0.607096607096607	HSD11B1/CYP11A1	-0.734178000812815
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/468	93/9376	0.646264130135098	EGFR/MAPK14/CALM3	-0.785768944427783
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/468	67/9376	0.598035463707105	PPP3CB/CALM3	-0.756819102735656
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/468	38/9376	0.527215474583896	QPRT	-0.669339688709364
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/468	38/9376	0.527215474583896	SCNN1B	-0.669339688709364
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/468	68/9376	0.589240824534942	ALDH1A2/DHRS3	-0.779169605735547
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/468	39/9376	0.513697129081744	DHFR	-0.697515588813856
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/468	148/9376	0.676830676830677	EGFR/LRP5/CCND1/WNT4/AKT2	-0.908292344990857
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/468	98/9376	0.613291470434328	PLCG1/PLCG2/CALM3	-0.882039563484369
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/468	41/9376	0.488638732541172	MAOA	-0.752109470848757
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/468	41/9376	0.488638732541172	RPA2	-0.752109470848757
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/468	154/9376	0.65046065046065	TPM1/MAPK14/TPM2/AKT2/CALM3	-1.00244911265122
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/468	323/9376	0.744304199412559	TIMP3/TPM1/EGFR/CD44/CCND1/PDCD4/PLCG1/CCNE2/VEGFA/PLCG2/HDAC5/IRS2	-1.07188219516713
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/468	75/9376	0.534245014245014	AKT2/GSTP1	-0.928200467109058
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/468	76/9376	0.527215474583896	ACTB/CALM3	-0.948521186199911
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/468	105/9376	0.572405372405372	ACTB/TPM1/TPM2	-1.00990857450457
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/468	47/9376	0.426259319876341	AKR1A1	-0.90378574450802
NA	NA	hsa04519	Cadherin signaling	15/468	404/9376	0.743843615130744	ACTB/KRT19/EGFR/KRT7/CDH13/MAPK14/LRP5/KRT8/MYO1E/CDH11/WNT4/RELA/APH1A/VANGL1/APH1B	-1.20633991006253
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/468	54/9376	0.371003482114593	BCAT1	-1.06245130030086
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/468	90/9376	0.445204178537512	SLC2A1/LDLR	-1.21215611594121
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/468	93/9376	0.430842753423399	LYZ/CALM3	-1.26429386148123
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/468	128/9376	0.469551282051282	GUK1/AK9/DGUOK	-1.38497820451176
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/468	63/9376	0.318002984669651	WNT4	-1.24487689888156
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/468	101/9376	0.396716594736397	WNT4/CALM3	-1.39715171276464
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/468	191/9376	0.524455184141048	HDAC7/HDAC5/HDAC11/MAOA/CALM3	-1.52190314829371
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/468	104/9376	0.385272846811308	PLPP1/AGPAT4	-1.44487679258166
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/468	226/9376	0.53188109825278	MYL9/FXYD1/RELA/F2R/AKT2/CALM3	-1.63274480479287
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/468	144/9376	0.417378917378917	MAPK14/WNT4/AKT2	-1.61487162866487
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/468	75/9376	0.267122507122507	GPX3	-1.46054739515007
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/468	370/9376	0.595610995610996	NPW/PRL/PRLR/TAC3/CSH1/RXFP1/ADRA2C/CHRNB1/C5AR1/F2R/TRH	-1.81908373031195
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/468	82/9376	0.244319366270586	GSTP1	-1.57529663430597
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/468	83/9376	0.241375759448049	HCFC1	-1.59113216037954
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/468	86/9376	0.23295567481614	SCNN1B	-1.63787325159558
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/468	86/9376	0.23295567481614	SLC2A1	-1.63787325159558
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/468	86/9376	0.23295567481614	ACTB	-1.63787325159558
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/468	89/9376	0.225103236339191	EGFR	-1.68352507064508
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/468	89/9376	0.225103236339191	GABARAP	-1.68352507064508
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/468	91/9376	0.220155912463605	ARRB1	-1.71338904790363
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/468	97/9376	0.206538020971011	CALM3	-1.80044500990885
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/468	183/9376	0.328429312035869	GTPBP4/RPP25/UTP14A	-2.1028442515864
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/468	115/9376	0.17421033073207	AKT2	-2.04224520065514
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/468	115/9376	0.17421033073207	MAOA	-2.04224520065514
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/468	116/9376	0.172708517536104	PPP3CB	-2.05494647730142
NA	NA	hsa04082	Neuroactive ligand signaling	2/468	199/9376	0.201348623459176	TAC3/ADRA2C	-2.61006833237679
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/468	449/9376	0.0892391449184322	ARRB1/CALM3	-4.53307829096035