category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	72/830	308/9376	2.64071350336411	MT-CO2/MT-CYB/MT-CO3/MT-ND3/TGM2/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/CLTC/DCTN4/COX7A1/PSMD2/PSMD14/POLR2G/PSMC5/NDUFC1/AP2A1/PSMB7/PSMC1/POLR2E/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/WIPI1/AP2M1/RB1CC1/PSMD3/ADRM1/ATG2A/CREB3/SDHC/NDUFS2/PSMD7/CREBBP/ATG14/KLC1/NDUFB7/TUBB4B/AP2S1/GPX3/ATG13/MT-ND4L/NDUFV1/CREB1/WIPI2/AP2B1/ACTR1A/MAP2K7/NDUFS6/TUBB6/DCTN5/SP1/CLTA/NDUFB1/HIP1/PSMB4/CREB3L2/NDUFA1/MT-ND6/NDUFS1/POLR2I/AMBRA1/ATP5PD/PSMC3/UQCRC1/GPX7/NDUFS7	9.12421678164473
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	62/830	275/9376	2.54682146768894	MT-CO2/MT-CYB/C1QB/C1QA/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/C1QC/NDUFA5/MT-CO1/CAV1/COX7A1/PSMD2/PSMD14/PSMC5/NDUFC1/PSMB7/PSMC1/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/PRNP/PPP3CB/ITPR2/PSMD3/EGR1/ADRM1/CREB3/MAPK14/SDHC/NDUFS2/PSMD7/KLC1/NDUFB7/TUBB4B/MT-ND4L/CYBA/NDUFV1/CREB1/NDUFS6/TUBB6/PRKACA/NDUFB1/PSMB4/CREB3L2/NDUFA1/MT-ND6/MAPK3/NDUFS1/CAV2/ITPR3/ATP5PD/PSMC3/UQCRC1/NDUFS7/TNF/CYBB	8.11344358451011
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	70/830	368/9376	2.14876898899948	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/DCTN4/COX7A1/PSMD2/PSMD14/RAB1A/SEC13/PSMC5/NDUFC1/PSMB7/PSMC1/VCP/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/WIPI1/PPP3CB/RB1CC1/PSMD3/ADRM1/ATG2A/MAPK14/SDHC/NDUFS2/PSMD7/TPR/ATG14/KLC1/NDUFB7/TUBB4B/GPX3/ATG13/MT-ND4L/NDUFV1/NUP62/WIPI2/DAXX/ACTR1A/NDUFS6/TUBB6/DCTN5/VAPB/SIGMAR1/NDUFB1/PSMB4/NDUFA1/ACTB/ANXA11/MT-ND6/NDUFS1/AMBRA1/ITPR3/ATP5PD/PSMC3/UQCRC1/GPX7/POM121/NDUFS7/TNF	7.00625054971866
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	56/830	268/9376	2.36043877000539	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/COX7A1/PSMD2/PSMD14/PSMC5/NDUFC1/PSMB7/PSMC1/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/UBE2G2/ITPR2/PSMD3/ADRM1/SLC39A7/SLC39A4/SDHC/NDUFS2/PSMD7/KLC1/NDUFB7/TUBB4B/MT-ND4L/MAOA/NDUFV1/SLC39A8/DAXX/NDUFS6/TUBB6/PRKACA/NFE2L2/KEAP1/NDUFB1/PSMB4/NDUFA1/UBA52/MT-ND6/NDUFS1/SLC39A6/ITPR3/ATP5PD/PSMC3/UQCRC1/NDUFS7	7.04170984996637
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	72/830	388/9376	2.0962364923612	MT-CO2/MT-CYB/MT-CO3/APOE/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/DKK1/MT-ND4/NDUFA5/MT-CO1/COX7A1/PSMD2/PSMD14/PSMC5/NDUFC1/ADAM17/PSMB7/PSMC1/APH1A/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/WIPI1/AKT2/WNT5A/PPP3CB/ITPR2/RB1CC1/PSMD3/ADRM1/SLC39A7/ATG2A/SLC39A4/SDHC/WNT4/NDUFS2/PSMD7/ATG14/KLC1/NDUFB7/TUBB4B/ATG13/MT-ND4L/NDUFV1/SLC39A8/WIPI2/MAP2K7/NDUFS6/TUBB6/CSNK1E/NDUFB1/PSMB4/NDUFA1/LRP1/MT-ND6/MAPK3/INSR/NDUFS1/GAPDH/SLC39A6/AMBRA1/ITPR3/ATP5PD/PSMC3/UQCRC1/NDUFS7/TNF/CYBB	6.87277025101863
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	38/830	155/9376	2.76943645549942	HLA-DRA/CTSL/HLA-DRB1/CD14/HLA-DRB5/HGS/DYNC1LI1/HLA-DQA1/STX7/ATP6V1E1/RAB7A/FCGR3A/HLA-DPA1/ATP6V0D1/RAB5C/SEC61A1/C1R/HLA-G/TUBB4B/MRC1/DYNC1H1/HLA-DPB1/CYBA/VAMP3/TUBB6/EEA1/ATP6V0A2/ATP6V1C1/HLA-DQB1/RAB5B/ACTB/ATP6V0B/FCGR2A/CTSS/CANX/DYNC2H1/DYNC1I2/CYBB	6.92237383170732
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	50/830	250/9376	2.25927710843373	PSAP/CTSL/CTSB/CD68/HEXB/CLTC/AP2A1/VPS35/GGA1/VPS26B/ATP6V1E1/RAB7A/BORCS5/ATP6V0D1/AP3D1/AP2M1/KXD1/AP1S2/SNAP29/ASAH1/OSBPL2/AP2S1/CLN8/NPC2/AP1G2/SCARB2/AP2B1/CTSH/ATP6V0A2/GALNS/ATP6V1C1/LAMTOR1/VPS16/HEXA/CLTA/LGMN/PPT1/ATP6V0B/ACP5/LAMTOR4/BORCS7/VPS18/AP5Z1/ARSG/CTSZ/CTSS/ROGDI/OSBPL1A/NPC1/RRAGA	6.28918429049059
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/830	138/9376	2.70130958617077	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/COX7A1/NDUFC1/ATP6V1E1/NDUFA3/MT-ATP8/MT-ND5/ATP6V0D1/SDHC/NDUFS2/NDUFB7/MT-ND4L/NDUFV1/NDUFS6/ATP6V0A2/ATP6V1C1/NDUFB1/NDUFA1/ATP6V0B/MT-ND6/NDUFS1/ATP5PD/UQCRC1/NDUFS7	6.27447153600227
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	77/830	480/9376	1.81212851405623	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/DKK1/MT-ND4/NDUFA5/MT-CO1/DCTN4/COX7A1/PSMD2/PSMD14/RAB1A/PSMC5/NDUFC1/PSMB7/PSMC1/VCP/NDUFA3/MT-ATP8/MT-ND5/PSMB6/PSMD1/WIPI1/UBE2G2/WNT5A/PRNP/PPP3CB/ITPR2/RB1CC1/PSMD3/ADRM1/ATG2A/MAPK14/SDHC/WNT4/NDUFS2/PSMD7/ATG14/KLC1/NDUFB7/TUBB4B/GPX3/ATG13/MT-ND4L/NDUFV1/ZFYVE1/WIPI2/DAXX/ACTR1A/MAP2K7/NDUFS6/TUBB6/CSNK1E/DCTN5/VAPB/SIGMAR1/NDUFB1/HIP1/PSMB4/NDUFA1/UBA52/MT-ND6/MAPK3/NDUFS1/AMBRA1/ITPR3/ATP5PD/PSMC3/UQCRC1/GPX7/NDUFS7/TNF/CYBB	5.69234522110073
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/830	227/9376	2.1896077702882	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/COX7A1/NDUFC1/EGFR/NDUFA3/MT-ATP8/MT-ND5/AKT2/PRKD2/JUN/PTPN1/MAPK14/SDHC/NDUFS2/PDPK1/NDUFB7/MT-ND4L/CYBA/NDUFV1/GSTO1/MAP2K7/NDUFS6/NFE2L2/KEAP1/NFKBIA/NDUFB1/NDUFA1/MGST3/MT-ND6/MAPK3/NDUFS1/FOXO3/ATP5PD/UQCRC1/NDUFS7	5.65422579040678
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	45/830	235/9376	2.16313765701102	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/COX7A1/NDUFC1/MGLL/RHEB/NDUFA3/MT-ATP8/MT-ND5/SMARCD2/COX16/CREB3/ACSL4/MAPK14/SDHC/NDUFS2/NDUFB7/PRKAG2/MT-ND4L/SMARCA4/NDUFV1/CREB1/TSC2/NDUFS6/PRKACA/NDUFB1/CREB3L2/NDUFA1/ACTB/RPS6KA2/MT-ND6/NDUFS1/ATP5PD/UQCRC1/NDUFS7/FRS2/CNR1	5.62744725602602
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/830	205/9376	2.20417278871584	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/NDUFA5/MT-CO1/COX7A1/G6PD/NDUFC1/MMP2/NDUFA3/MT-ATP8/MT-ND5/AKT2/MAPK14/SDHC/NDUFS2/TBC1D4/NDUFB7/TGFBR1/MT-ND4L/CYBA/NDUFV1/NDUFS6/SP1/NDUFB1/NDUFA1/MT-ND6/INSR/NDUFS1/GAPDH/PPP1CA/ATP5PD/UQCRC1/NDUFS7/CYBB	5.43251123260781
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/830	44/9376	3.59430449069003	DCTN4/DYNC1LI1/RAB11A/DYNLL2/RAB5C/CREB3/DYNC1H1/CREB1/PRKACA/DCTN5/CREB3L2/RAB5B/DYNC2H1/DYNC1I2	5.37530560850421
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	33/830	174/9376	2.14241794765268	CRYAB/SEL1L/KRTCAP2/SSR1/SEC13/SELENOS/BAG1/OS9/VCP/SEC63/STUB1/UBE2G2/RPN1/UBXN2A/SEC61A1/GANAB/BCAP31/LMAN2/ERLEC1/PRKCSH/MAP2K7/NFE2L2/NPLOC4/STT3A/MAN1A1/MAN1A2/DNAJC1/NSFL1C/SSR3/CKAP4/AMFR/PPP1R15A/CANX	4.7402556787759
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/830	95/9376	2.61600507292327	FLT1/HLA-DRA/CTSL/HLA-DRB1/HLA-DRB5/ITGAL/CCL2/HLA-DQA1/ATP6V1E1/HLA-DPA1/ATP6V0D1/JUN/HLA-DPB1/ATP6V0A2/ATP6V1C1/HLA-DQB1/CXCL3/ATP6V0B/ACP5/ICAM1/CCL3L1/TNF	4.93344596948845
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	41/830	238/9376	1.94601599676015	RPL13A/C1QB/C1QA/RPS26/RPS20/RPS11/CFD/PLCG2/C1QC/RPL8/RPLP0/RPS16/RPL7/RPS8/RPL28/CCL2/ADAM17/RPL10/RPL18A/EGFR/RPS28/JUN/IFNAR1/C1R/MAPK14/IFIH1/C5AR1/RPL26L1/RPL37A/NFKBIA/IL6ST/UBA52/IFNAR2/C1S/MAPK3/FCGR2A/RPS4Y1/MAVS/RPS17/TNF/CYBB	4.60685583703649
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/830	169/9376	2.13896057603194	CTSL/CTSB/RAB1A/WDR45B/STX7/RAB7A/RHEB/WIPI1/AKT2/RB1CC1/ATG2A/RUBCN/SNAP29/ATG14/PDPK1/ATG13/ZFYVE1/WIPI2/TSC2/GABARAPL1/PRKACA/VPS16/UVRAG/EIF2AK4/ATG10/UBA52/MAPK3/CAMKK2/VPS18/ATG16L2/AMBRA1/RRAGA	4.65624916867465
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	29/830	149/9376	2.19862537397914	MT-ND3/MT-ND1/MT-ND2/MT-ND4/NDUFA5/NDUFC1/MGLL/NDUFA3/MT-ND5/ITPR2/GNB5/GNB1/MAPK14/NDUFS2/NDUFB7/MT-ND4L/NDUFV1/NDUFS6/PRKACA/NDUFB1/NDUFA1/GNG11/GNB2/MT-ND6/MAPK3/NDUFS1/ITPR3/NDUFS7/CNR1	4.59610118392912
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	36/830	205/9376	1.98375550984425	HLA-DRA/HLA-DRB1/PLCG2/HLA-DRB5/PSMD2/PSMD14/PSMC5/ITGAL/HLA-DQA1/PSMC1/PSMD1/CDK4/HLA-DPA1/AKT2/JUN/PSMD3/IFNAR1/ADRM1/MAPK14/HLA-G/PSMD7/VIM/HLA-DPB1/RELB/NFKB2/MAP2K7/NFKBIA/RBPJ/HLA-DQB1/IFNAR2/ICAM1/LYN/MAVS/PSMC3/CCND1/TNF	4.4381196016462
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/830	46/9376	3.19245678365636	PSMD2/PSMD14/PSMC5/PSMB7/PSMC1/PSMB6/PSMD1/PSME3/PSMD3/ADRM1/PSMD7/PSMB4/PSMC3	4.64528512280574
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	21/830	99/9376	2.39620299379336	HLA-DRA/C1QB/C1QA/KRT18/KRT19/HLA-DRB1/CFD/C1QC/HLA-DRB5/ITGAL/SELPLG/HLA-DQA1/FCGR3A/HLA-DPA1/C1R/C5AR1/HLA-DPB1/HLA-DQB1/C1S/ICAM1/FCGR2A	4.35216772581055
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	37/830	224/9376	1.86592082616179	HLA-DRA/HLA-DRB1/IL1R1/HLA-DRB5/ITGAL/IL1R2/HLA-DQA1/CDK4/XIAP/RANBP3/HLA-DPA1/AKT2/PPP3CB/JUN/EGR1/CREB3/HLA-G/CREBBP/TGFBR1/HLA-DPB1/SRF/RELB/CREB1/NFKB2/ANAPC15/PRKACA/NFKBIA/HLA-DQB1/CD4/CREB3L2/ANAPC11/MAPK3/ICAM1/CANX/CCND1/TNF/STAT5B	4.08777919090347
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/830	82/9376	2.47969438730532	CD74/HLA-DRA/CTSL/HLA-DRB1/CTSB/HLA-DRB5/HLA-DQA1/PSME3/HLA-DPA1/HLA-G/HLA-DPB1/CREB1/LGMN/HLA-DQB1/CD4/CTSS/CANX/TNF	4.19392692199676
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	26/830	142/9376	2.06835228236891	PLCG2/IL1R1/FCGR3A/AKT2/PPP3CB/ITPR2/JUN/IFNAR1/MAPK14/TGFBR1/CYBA/RELB/CREB1/NFKB2/MAP2K7/NFKBIA/ACP5/LILRB1/IFNAR2/FHL2/MAPK3/TNFRSF11B/FCGR2A/CSF1R/ITPR3/TNF	3.99767016843367
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	39/830	248/9376	1.77644772638943	MYL9/CD14/DCTN4/DYNC1LI1/RAB7A/DYNLRB1/TCF7L2/PIK3C2A/DYNLL2/AKT2/TAB3/JUN/RAB5C/ANXA2/RHOG/RALA/MAPK14/PKN1/SNX9/KLC1/TUBB4B/DYNC1H1/ACTR1A/MAP2K7/EXOC7/TUBB6/DCTN5/NFKBIA/VPS16/PLEKHM2/RAB5B/ACTB/AHNAK2/MAPK3/GAPDH/VPS18/DYNC2H1/TNF/DYNC1I2	3.86183298305706
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	39/830	250/9376	1.76223614457831	RAB31/CLTC/CAV1/CHMP4B/EHD1/HGS/USP8/RAB11A/AP2A1/VPS35/EGFR/VPS26B/RAB7A/DAB2/AP2M1/SH3GLB2/CHMP1A/VPS4A/RAB5C/HLA-G/WIPF2/SPG21/WWP1/AP2S1/CAPZB/TGFBR1/AGAP3/CHMP6/AP2B1/WASHC3/EEA1/EHD2/CLTA/RAB5B/FOLR2/EHD4/ARFGAP1/CAV2/CHMP3	3.80682182977862
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	25/830	144/9376	1.96117804551539	PSMD2/PSMD14/PSMC5/PSMB7/PSMC1/PSMB6/PSMD1/WIPI1/AKT2/ITPR2/RB1CC1/PSMD3/ADRM1/ATG2A/PSMD7/ATG14/ATG13/WIPI2/SP1/CIC/RBPJ/PSMB4/AMBRA1/ITPR3/PSMC3	3.62226676136102
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/830	56/9376	2.6223752151463	KRTCAP2/MAN2A1/MGAT1/RPN1/DPM3/GANAB/DPM2/STT3A/DHRSX/MAN1A1/MAN1A2/ALG3/ALG1	3.79472755166603
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/830	196/9376	1.78667322350627	PLCG2/MAPKAPK2/CDK4/TCF7L2/AKT2/PPP3CB/ITPR2/JUN/IFNAR1/GNB5/GNB1/MAPK14/HLA-G/CREBBP/ATG14/CREB1/MAP2K7/NFKBIA/CXCL3/IL6ST/GNG11/UBA52/GNB2/IFNAR2/PIK3R5/MAPK3/ICAM1/MICA/LYN/ITPR3/CCND1	3.46852080057947
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/830	78/9376	2.31720729070127	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/FCGR3A/HLA-DPA1/JUN/MAPK14/HLA-DPB1/CYBA/NFKBIA/HLA-DQB1/MAPK3/FCGR2A/TNF/CYBB	3.64040662813804
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/830	93/9376	2.18639720171007	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/PPP3CB/JUN/MAPK14/MAF/STAT6/HLA-DPB1/NFKBIA/RBPJ/HLA-DQB1/CD4/IL12RB1/MAPK3/STAT5B	3.58319672810141
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/830	101/9376	2.1250626267446	FN1/SERPINE1/PLCG2/CCL2/MMP2/CDK4/AKT2/JUN/EGR1/MAPK14/VEGFB/TGFBR1/MAPK3/ICAM1/F3/CCND1/TNF/CYBB/STAT5B	3.54261262543613
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/830	44/9376	2.82409638554217	HEXB/KRTCAP2/MAN2A1/MGAT1/RPN1/HEXA/STT3A/MAN1A1/MAN1A2/ALG3/ALG1	3.77946211281049
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	20/830	109/9376	2.07273129214104	HLA-DRA/HLA-DRB1/EBI3/IL1R1/HLA-DRB5/HLA-DQA1/HLA-DPA1/PPP3CB/JUN/MAPK14/STAT6/TGFBR1/HLA-DPB1/NFKBIA/HLA-DQB1/CD4/IL6ST/IL12RB1/MAPK3/STAT5B	3.51057177689446
Human Diseases	Immune disease	hsa05310	Asthma	9/830	32/9376	3.17710843373494	HLA-DRA/HLA-DRB1/PRG2/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-DPB1/HLA-DQB1/TNF	3.84442926527229
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/830	181/9376	1.7475071556946	CD74/HLA-DRA/HLA-DRB1/CD14/HLA-DRB5/HLA-DQA1/RAB7A/FCGR3A/HLA-DPA1/ATP6V0D1/AKT2/PPP3CB/RAB5C/MAPK14/CREBBP/MRC1/HLA-DPB1/CREB1/EEA1/ATP6V0A2/HLA-DQB1/RAB5B/ATP6V0B/MAPK3/IRAK2/FCGR2A/CTSS/TNF	3.16462325545257
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	25/830	157/9376	1.79878750671476	MT-CO2/MT-CYB/MT-CO3/NDUFA5/MT-CO1/COX7A1/NDUFC1/NDUFA3/AKT2/JUN/MAPK14/SDHC/NDUFS2/NDUFB7/PRKAG2/NDUFV1/NDUFS6/NDUFB1/MAP3K11/NDUFA1/INSR/NDUFS1/UQCRC1/NDUFS7/TNF	3.14544736782721
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/830	70/9376	2.25927710843373	HLA-DRA/HLA-DRB1/HLA-DRB5/CAV1/ITGAL/EIF4G1/HLA-DQA1/HLA-DPA1/HLA-G/HLA-DPB1/HLA-DQB1/ACTB/ICAM1/CCND1	3.2955814126428
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/830	71/9376	2.2274563040896	PLCG2/ADAM17/EGFR/ATP6V1E1/ATP6V0D1/JUN/MAPK14/ATP6V0A2/ATP6V1C1/NFKBIA/CXCL3/ATP6V0B/JAM2/LYN	3.23534252800238
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/830	203/9376	1.6694165825865	FN1/FLT1/SPP1/MYL9/CAV1/EGFR/ITGB8/ILK/COL6A3/XIAP/VCL/ARHGAP5/AKT2/JUN/ITGA1/PDPK1/CRK/VEGFB/ZYX/LAMA3/ACTB/KDR/MAPK3/PPP1R12C/EMP1/CAV2/PPP1CA/LAMA4/COL6A2/CCND1	3.00491387280495
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/830	204/9376	1.66123316796598	TIMP3/FN1/LUM/DCN/CTSL/PLCG2/CAV1/EGFR/MMP2/AKT2/WNT5A/ITPR2/MAPK14/WNT4/PDPK1/PLAUR/PRKACA/DROSHA/ACTB/KDR/SLC9A1/MAPK3/PPP1R12C/CAV2/PPP1CA/HSPG2/ITPR3/CCND1/FRS2/TNF	2.97564371874492
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/830	88/9376	2.0538882803943	SERPINE2/C1QB/C1QA/SERPINE1/CFD/SERPING1/C1QC/F2R/TFPI/CLU/C1R/A2M/PLAUR/C5AR1/C1S/F3	3.09540904921933
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/830	51/9376	2.43647531301677	PLCG2/ATP6V1E1/ATP6V0D1/SEC61A1/KDELR2/PRKACA/ATP6V0A2/ATP6V1C1/KDELR1/ACTB/ATP6V0B	3.20554645173223
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/830	31/9376	2.91519626894675	SRP68/SEC11C/SEC63/TMEM208/OXA1L/SEC61A1/BAG6/SGTA	3.32849356150301
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/830	39/9376	2.60685820203893	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-G/HLA-DPB1/HLA-DQB1/TNF	3.13364227988944
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/830	205/9376	1.59802527181898	UBR4/PSMC1/MAPKAPK2/SND1/CDK4/YWHAG/ATP6V0D1/JUN/YWHAQ/CREB3/HLA-G/YWHAH/CREBBP/HDAC7/SRF/MRPS18B/CREB1/NFKB2/DDB1/PRKACA/NFKBIA/RBPJ/CREB3L2/IL6ST/MAPK3/GTF2E2/LYN/CCND1/STAT5B	2.6979342474634
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/830	10/9376	4.51855421686747	PAPSS2/TST/ETHE1/SQOR	3.4692085720605
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/830	63/9376	2.1516924842226	POLE3/POLR2G/XPC/POLR2E/CUL4A/ERCC6/POLE4/DDB1/POLD2/LIG1/POLR2I/UVSSA	2.85828313036017
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/830	42/9376	2.42065404475043	FTH1/FTL/SAT1/SLC40A1/PRNP/ACSL4/GPX4/SLC39A8/CYBB	2.87555924135743
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/830	105/9376	1.82893861158921	USP8/RAB7A/VCP/JUN/RAB5C/TBC1D15/MUL1/RABGEF1/GABARAPL1/SP1/RAB5B/UBA52/FOXO3/AMFR/RHOT2/MTX1/AMBRA1	2.66193207000019
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/830	66/9376	2.0538882803943	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/JUN/MAF/STAT6/HLA-DPB1/HLA-DQB1/IL12RB1/TNF	2.67753368027259
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/830	44/9376	2.31062431544359	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-G/HLA-DPB1/HLA-DQB1/TNF	2.71556644901467
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/830	30/9376	2.63582329317269	IDH3B/IDH3G/SDHC/OGDH/ACO2/IDH1/ACO1	2.79658077100157
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/830	233/9376	1.50295258286364	FN1/DCN/MYL9/FBLN1/TPM1/VCAN/ITGB8/COL6A3/PDLIM1/VCL/ENO2/TTN/FBN1/PDLIM4/ITGA1/BGN/VIM/TPM2/DIAPH2/DSP/CAPZB/ZYX/DAAM1/ACTB/NID1/FHL2/SYNE1/PDLIM7/HSPG2/SYNE2/COL6A2	2.42272367646527
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/830	45/9376	2.25927710843373	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-G/HLA-DPB1/HLA-DQB1/TNF	2.63880143147029
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/830	38/9376	2.37818642993025	HEXB/PMM1/HEXA/GPI/NAGK/GNPNAT1/GALK2/GALK1	2.65287063841827
NA	NA	hsa04518	Integrin signaling	22/830	154/9376	1.61376936316695	FN1/FLT1/SPP1/FERMT2/ITGAL/EGFR/ITGB8/ILK/COL6A3/VCL/AKT2/FBN1/ITGA1/VEGFB/LAMA3/ACTB/KDR/ICAM1/LIMS2/LAMA4/COL6A2/CCND1	2.3932950803252
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/830	119/9376	1.70869697276501	CCL2/ADAM17/XIAP/AKT2/TAB3/JUN/CREB3/MAPK14/CREB1/MAP2K7/NFKBIA/CXCL3/CREB3L2/RHBDF2/MAPK3/ICAM1/MMP14/TNF	2.42461153311506
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/830	227/9376	1.49291438883286	IL1R1/CCL2/EGFR/RHEB/CDK4/AKT2/PPP3CB/ITPR2/GNB5/CREB3/GNB1/MAPK14/HLA-G/CRK/CREB1/TSC2/CCL4L2/PRKACA/NFKBIA/SP1/CREB3L2/PTGER4/GNG11/GNB2/MAPK3/CCL3L1/EIF4EBP1/ITPR3/CCND1/TNF	2.34283040125585
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/830	103/9376	1.75477833664756	FN1/HSPB1/CD14/IL1R1/PRDX1/IL1R2/RAB7A/VCL/RAB5C/PRKACA/CXCL3/LAMA3/RAB5B/SERPINB6/LAMA4/TNF	2.40033108456822
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	41/830	333/9376	1.3908462679547	FN1/SPP1/UBR4/EGFR/ITGB8/ATP6V1E1/NFX1/PSMC1/RHEB/COL6A3/CDK4/TCF7L2/ATP6V0D1/AKT2/WNT5A/IFNAR1/CREB3/HLA-G/WNT4/ITGA1/CREBBP/BCAP31/PPP2R1A/CREB1/TSC2/PRKACA/ATP6V0A2/ATP6V1C1/RBPJ/CREB3L2/LAMA3/ATP6V0B/PTGER4/IFNAR2/MAPK3/EIF4EBP1/LAMA4/RFNG/COL6A2/CCND1/TNF	2.26315896952914
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/830	112/9376	1.71462994836489	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/XIAP/HLA-DPA1/AKT2/MAPK14/PDPK1/HLA-DPB1/NFKBIA/HLA-DQB1/LAMA3/PIK3R5/MAPK3/LAMA4/TNF	2.37101439526268
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/830	130/9376	1.65101019462465	EGFR/MMP2/AKT2/JUN/GNB5/CREB3/GNB1/MAPK14/VEGFB/TGFBR1/CREB1/MAP2K7/PRKACA/NFKBIA/CREB3L2/GNG11/GNB2/RXFP1/MAPK3	2.32930179463479
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/830	194/9376	1.51394857781642	MYL9/TPM1/DCTN4/DYNC1LI1/DYNLRB1/MYO9B/DYNLL2/MYL6/MYO1G/KIF21A/TPM2/KLC1/TUBB4B/KIF20B/CAPZB/DYNC1H1/ACTR1A/TUBB6/DCTN5/ACTB/MYO10/MYO5A/MYO18A/KIF1B/DYNC2H1/DYNC1I2	2.25421393172838
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/830	142/9376	1.59104021720686	CTSL/IL1R1/CAV1/CCL2/IL1R2/MMP2/AKT2/JUN/MAPK14/CYBA/GSTO1/MAP2K7/NFE2L2/KEAP1/ACTB/MGST3/KDR/ICAM1/CAV2/TNF	2.21161491735037
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/830	90/9376	1.75721552878179	RHEB/AKT2/RB1CC1/CREB3/PRKAG2/ATG13/CREB1/TSC2/PRKACA/CREB3L2/CAMKK2/INSR/FOXO3/EIF4EBP1	2.24941541498141
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/830	65/9376	1.91169601482855	ITPR2/CREB3/NR4A1/CYP11A1/CREB1/PRKACA/SP1/HSD3B1/CREB3L2/KCNK3/ITPR3	2.29853865398759
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/830	180/9376	1.50618473895582	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/CCL2/HLA-DQA1/RHEB/HLA-DPA1/AKT2/IFNAR1/HLA-G/IFIH1/POU2F1/HLA-DPB1/DAXX/TSC2/EIF2B4/NFKBIA/HLA-DQB1/IFNAR2/PPP1CA/MAVS/EIF4EBP1/TNF	2.13692391198131
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/830	362/9376	1.34183585169407	FN1/FLT1/SPP1/PRL/PRLR/F2R/EGFR/ITGB8/RHEB/COL6A3/CDK4/YWHAG/AKT2/CSH1/IFNAR1/YWHAQ/GNB5/CREB3/GNB1/PKN1/ITGA1/YWHAH/NR4A1/PDPK1/VEGFB/PPP2R1A/CREB1/TSC2/CREB3L2/LAMA3/KDR/GNG11/GNB2/IFNAR2/PIK3R5/MAPK3/INSR/FOXO3/CSF1R/EIF4EBP1/LAMA4/COL6A2/CCND1	2.06707558816935
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/830	28/9376	2.42065404475043	HADHA/HSD17B12/ELOVL1/PPT1/TECR/MECR	2.34612547964927
Genetic Information Processing	Translation	hsa03010	Ribosome	28/830	222/9376	1.42476934766091	RPL13A/RPS26/RPS20/RPS11/RPL8/RPLP0/RPS16/RPL7/RPS8/RPL28/RPL10/RPL18A/RPS28/MRPL41/MRPL55/MRPL20/MRPL28/MRPS21/MRPL12/MRPS18B/RPL26L1/RPL37A/UBA52/MRPL23/MRPL37/RPS4Y1/MRPL24/RPS17	1.99603173942236
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/830	52/9376	1.95514365152919	APOE/APOC1/PLTP/LRPAP1/APOA1/NPC2/VAPB/LRP1/NPC1	2.15234791024379
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/830	122/9376	1.57408650997432	PLCG2/RHEB/AKT2/DIO2/MED13L/WNT4/CREBBP/TBC1D4/PDPK1/TSC2/PRKACA/MED12/ACTB/SLC9A1/MED16/MAPK3/CCND1	1.98900442691452
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/830	78/9376	1.73790546802595	C1QB/C1QA/SERPING1/C1QC/CD14/JUN/C1R/MAPK14/C1S/MAPK3/CFL2/TNF	2.03937222007846
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/830	53/9376	1.91825414867015	CLTC/RAB11A/AP2A1/AP2M1/AP2S1/ATP2B1/AP2B1/PRKACA/CLTA	2.08913368668123
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/830	79/9376	1.71590666463322	CLTC/AP2A1/ATP6V1E1/NAPA/ATP6V0D1/AP2M1/AP2S1/AP2B1/ATP6V0A2/ATP6V1C1/CLTA/ATP6V0B	1.99132330185014
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/830	30/9376	2.25927710843373	MTR/FPGS/ABCC4/MTHFR/FOLR2/TNF	2.15284264596694
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/830	173/9376	1.43653457761683	HLA-DRA/HLA-DRB1/HLA-DRB5/RAB11A/CCL2/HLA-DQA1/CDK4/HLA-DPA1/AKT2/IFNAR1/CREBBP/IFIH1/HLA-DPB1/NFKBIA/HLA-DQB1/KPNA6/ACTB/IFNAR2/MAPK3/ICAM1/MAVS/TNF	1.80601033093551
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/830	99/9376	1.5974686625289	EGFR/PLPP3/RHEB/AKT2/PCYT1A/JUN/DGKA/PDPK1/TSC2/RALGDS/SP1/CHPT1/MAPK3/EIF4EBP1	1.86239668715847
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/830	73/9376	1.70219508169665	CHMP4B/AFF4/MAP1B/HGS/PIN1/VPS4A/CREBBP/CHMP6/SUPT5H/SERINC3/CD4	1.87694239085738
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/830	155/9376	1.45759813447338	USP8/EGFR/CDK4/TCF7L2/WNT5A/ITPR2/CREB3/ARMC5/WNT4/NR4A1/CYP11A1/CREB1/PRKACA/SP1/HSD3B1/CREB3L2/KCNK3/MAPK3/ITPR3/CCND1	1.79021142108352
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/830	109/9376	1.55454846910578	AKT2/PTPN1/CREB3/TBC1D4/PDPK1/PRKAG2/CREB1/NFKBIA/CREB3L2/RPS6KA2/PYGB/PTPRF/INSR/PPP1CA/TNF	1.81479017049763
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/830	100/9376	1.58149397590361	HLA-DRA/HLA-DRB1/CD14/IL1R1/HLA-DRB5/IL1R2/HLA-DQA1/HLA-DPA1/ITGA1/HLA-DPB1/HLA-DQB1/CD4/CSF1R/TNF	1.8218310100914
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/830	17/9376	2.65797306874557	MTR/PAPSS2/KYAT3/SCLY	2.13221232306776
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/830	137/9376	1.48419664057691	CTSL/CTSB/XIAP/AKT2/ITPR2/JUN/PDPK1/CSF2RB/DAXX/CTSH/NFKBIA/ACTB/MAPK3/CTSZ/CTSS/ITPR3/TNF/ENDOG	1.77915101240425
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/830	32/9376	2.11807228915663	WIPI1/ATG2A/ATG13/WIPI2/GABARAPL1/ATG10	1.97433888111383
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/830	214/9376	1.37245805652517	PLCG2/CUL4A/AKT2/PPP3CB/ITPR2/JUN/GNB5/GNB1/MAPK14/HLA-G/AP1S2/CRK/AP1G2/ELOB/DDB1/MAP2K7/NFKBIA/CD4/FBXW11/GNG11/GNB2/MAPK3/CFL2/ITPR3/LIMK2/TNF	1.71764083296092
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/830	138/9376	1.47344159245678	RHEB/AKT2/PTPN1/PHKG1/PDPK1/CRK/PRKAG2/PRKAR2A/INPPL1/TSC2/EXOC7/PRKACA/PYGB/PTPRF/MAPK3/INSR/PPP1CA/EIF4EBP1	1.74606422016099
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/830	57/9376	1.78363982244769	HADHA/HSD17B12/ACAA1/ELOVL1/ACSL4/PPT1/TECR/ACSF3/MECR	1.84932188713545
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/830	157/9376	1.43903000537181	IGFBP3/SERPINE1/NBN/RHEB/MAPKAPK2/CDK4/AKT2/PPP3CB/ITPR2/MAPK14/HLA-G/TGFBR1/TSC2/FBXW11/MAPK3/FOXO3/PPP1CA/EIF4EBP1/ITPR3/CCND1	1.72880242014982
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/830	120/9376	1.50618473895582	PLCG2/MAPKAPK2/AKT2/JUN/MAPK14/PDPK1/SH2B3/CRK/MAP2K7/NFKBIA/RPS6KA2/MAPK3/BEX3/IRAK2/FOXO3/FRS2	1.73912675984125
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/830	75/9376	1.65680321285141	IDH3B/MTR/ENO2/PYCR2/IDH3G/ACO2/IDH1/PRPS2/ALDH18A1/GAPDH/ACO1	1.77968982798244
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/830	93/9376	1.57906464567949	MYL9/EGFR/KRIT1/TCF7L2/VCL/PTPN1/CREBBP/TGFBR1/ACTB/PTPRF/MAPK3/INSR/AFDN	1.7489105172932
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/830	33/9376	2.0538882803943	IDH3B/IDH3G/OGDH/ACO2/IDH1/ACO1	1.88995563966577
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/830	103/9376	1.53543104456662	C1QB/C1QA/SERPINE1/C1QC/CCL2/AKT2/JUN/MAPK14/TGFBR1/PPP2R1A/NFKBIA/MAPK3/CCL3L1/TNF	1.70276718012934
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/830	34/9376	1.99347980155918	POLR2G/POLR2E/POLR3D/POLR1A/POLR1C/POLR2I	1.80851372528864
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/830	34/9376	1.99347980155918	RORB/FBXL3/PRKAG2/CREB1/CSNK1E/FBXW11	1.80851372528864
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/830	142/9376	1.43193619548617	MGRN1/STUB1/XIAP/UBE2G2/CUL4A/UBE2K/SAE1/WWP1/UBE2R2/ELOB/ANAPC15/DDB1/KEAP1/FBXW11/UBA52/ANAPC11/CDC34/UBE3C	1.61626316698927
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/830	133/9376	1.44389890388622	AKT2/PPP3CB/ITPR2/GNB5/CREB3/GNB1/COMT/MAPK14/PPP2R1A/MAOA/CREB1/PRKACA/CREB3L2/GNG11/GNB2/PPP1CA/ITPR3	1.60674388873126
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	34/830	300/9376	1.28025702811245	FLT1/HSPB1/CD14/IL1R1/EGFR/MAP4K4/MAPKAPK2/AKT2/PPP3CB/JUN/MAP3K2/MAPK14/NR4A1/CRK/VEGFB/TGFBR1/SRF/RELB/NFKB2/DAXX/MAP2K7/PRKACA/MAP3K13/MAP3K11/MAPK8IP3/RASA1/RPS6KA2/KDR/PPP5C/MAPK3/INSR/RASGRP2/CSF1R/TNF	1.53749296143113
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/830	163/9376	1.38605957572622	AKT2/JUN/IFNAR1/YWHAQ/CREB3/MAPK14/STAT6/CREBBP/IFIH1/TGFBR1/CREB1/DDB1/MAP2K7/NFKBIA/CREB3L2/MAPK3/MAVS/HSPG2/TNF/STAT5B	1.54949734284039
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/830	61/9376	1.66667983409046	FTH1/FTL/SLC40A1/SLC39A4/SLC31A1/MT1X/HMOX2/ATP2B1/CYBRD1	1.62792370318056
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/830	116/9376	1.46073950976319	G6PD/IDH3B/ENO2/IDH3G/SDHC/OGDH/ACO2/ACSS1/IDH1/PRPS2/GPI/GCSH/GAPDH/PGLS/ACO1	1.55604516084295
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/830	116/9376	1.46073950976319	MYL9/THY1/PLCG2/ITGAL/MMP2/VCL/ARHGAP5/MAPK14/CLDN5/CYBA/ACTB/JAM2/ICAM1/AFDN/CYBB	1.55604516084295
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/830	98/9376	1.49850012294074	PLCG2/MARCKS/PLPP3/FCGR3A/AKT2/CRK/INPPL1/MYO10/MAPK3/FCGR2A/LYN/CFL2/LIMK2	1.54594615571789
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/830	98/9376	1.49850012294074	ATF1/PRKD2/ITPR2/CREB3/NR4A1/CYP11A1/CREB1/ATP2B1/PRKACA/HSD3B1/CREB3L2/KCNK3/ITPR3	1.54594615571789
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/830	157/9376	1.36707850510322	C1QB/C1QA/C1QC/ADAM17/RAB7A/MAPKAPK2/RAB5C/MAPK14/CRK/CREB1/AXL/VPS16/MFGE8/RAB5B/PTGER4/TGFBRAP1/LRP1/MAPK3/VPS18	1.44547343061434
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/830	109/9376	1.45091190449873	SPP1/CD14/AKT2/JUN/IFNAR1/MAPK14/MAP2K7/CCL4L2/NFKBIA/IFNAR2/TOLLIP/MAPK3/CCL3L1/TNF	1.47563384921826
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/830	54/9376	1.6735385988398	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-G/HLA-DPB1/HLA-DQB1	1.54684949503109
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/830	138/9376	1.39158372620918	YWHAG/SMC1A/PPP3CB/ITPR2/YWHAQ/MAPK14/YWHAH/PPP2R1A/ANAPC15/PRKACA/FBXW11/RPS6KA2/ANAPC11/MAPK3/AURKA/PPP1CA/ITPR3	1.4441703991049
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/830	138/9376	1.39158372620918	FN1/CCL2/AKT2/JUN/RHOG/MAPK14/PKN1/WIPF2/CRK/MAP2K7/NFKBIA/CD4/ACTB/RPS6KA2/MAPK3/FCGR2A/TNF	1.4441703991049
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/830	37/9376	1.83184630413546	PMM1/GPI/NAGK/GNPNAT1/GALK2/GALK1	1.57992694503101
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/830	158/9376	1.3584261095013	SEC13/ATP6V1E1/RHEB/MAPKAP1/AKT2/WNT5A/CLIP1/WNT4/PDPK1/TSC2/ATP6V1C1/LAMTOR1/RPS6KA2/MAPK3/INSR/LAMTOR4/EIF4EBP1/TNF/RRAGA	1.4159667979513
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/830	110/9376	1.43772179627601	FLT1/TIMP1/SERPINE1/PLCG2/EGFR/ENO2/AKT2/CREBBP/ELOB/MAPK3/INSR/GAPDH/EIF4EBP1/CYBB	1.43910210208974
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/830	140/9376	1.37170395869191	SERPINE1/SPP1/AKT2/ITPR2/EGR1/GNB5/GNB1/PRKAG2/TGFBR1/PRKACA/GNG11/GNB2/SLC9A1/PIK3R5/MAPK3/ITPR3/CCND1	1.38090080336519
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/830	93/9376	1.45759813447338	EGFR/MMP2/ITPR2/JUN/EGR1/MAP3K2/MAPK14/MAP2K7/PRKACA/MAPK3/MMP14/ITPR3	1.38205327513156
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/830	56/9376	1.61376936316695	CD14/RAB1A/VCP/RAB1B/NFKB2/NFKBIA/CXCL3/TNF	1.43560348496086
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/830	122/9376	1.38889986174205	IGFBP3/PLCG2/AKT2/CSH1/ITPR2/CREB3/MAPK14/CREBBP/CRK/CREB1/PRKACA/CREB3L2/MAPK3/ITPR3/STAT5B	1.3473989254093
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/830	30/9376	1.88273092369478	MPPE1/PIGF/DPM2/PIGX/PIGP	1.5091045209323
NA	NA	hsa03272	Virion - Hepatitis viruses	7/830	48/9376	1.64738955823293	CHMP4B/CD81/EGFR/CHMP1A/VPS4A/CLDN5/HSPG2	1.40131341791144
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/830	31/9376	1.82199766809172	GRHPR/ACO2/ACSS1/GCSH/ACO1	1.42858149327872
NA	NA	hsa04981	Folate transport and metabolism	5/830	31/9376	1.82199766809172	MTR/FPGS/ABCC4/MTHFR/FOLR2	1.42858149327872
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/830	144/9376	1.33360107095047	C1QB/C1QA/C1QC/CD14/TCF7L2/AKT2/TAB3/MAPK14/C5AR1/PRKAG2/MAP2K7/NFKBIA/CXCL3/CAMKK2/FOXO3/CCND1/TNF	1.25719899294034
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/830	105/9376	1.39860011474469	PLCG2/CD14/IL1R1/XIAP/TAB3/RELB/NFKB2/CCL4L2/NFKBIA/CXCL3/ICAM1/LYN/TNF	1.28000603869863
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/830	105/9376	1.39860011474469	PLCG2/MAPKAPK2/AKT2/PPP3CB/ITPR2/JUN/MAPK14/RELB/NFKB2/NFKBIA/MAPK3/ITPR3/TNF	1.28000603869863
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/830	77/9376	1.4670630574245	CDK4/CTBP1/AKT2/CRK/TGFBR1/NFKBIA/MAPK3/BCR/CCND1/STAT5B	1.28246640344679
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/830	106/9376	1.38540577403955	IL1R2/EGFR/TCF7L2/AKT2/CREB3/CREBBP/PDPK1/CREB1/NFKBIA/CREB3L2/FOLR2/MAPK3/CCND1	1.24358227274745
Organismal Systems	Immune system	hsa04611	Platelet activation	15/830	126/9376	1.34480780263913	PLCG2/F2R/APBB1IP/AKT2/ITPR2/MAPK14/PRKACA/ACTB/PIK3R5/MAPK3/FCGR2A/LYN/RASGRP2/PPP1CA/ITPR3	1.2143244269499
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/830	59/9376	1.53171329385338	G6PD/GPX3/GPX4/IDH1/GSTO1/RRM1/MGST3/GPX7	1.27675837953648
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/830	59/9376	1.53171329385338	EGFR/ILK/TCF7L2/AKT2/PDPK1/MAPK3/FOXO3/CCND1	1.27675837953648
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/830	78/9376	1.44825455668829	FN1/CLTC/CAV1/ILK/VCL/RHOG/CRK/CLTA/ACTB/CAV2	1.23885501604866
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/830	50/9376	1.58149397590361	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-DPB1/HLA-DQB1	1.28477109344821
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/830	50/9376	1.58149397590361	ITGAL/CCL2/CD81/HBB/LRP1/ICAM1/TNF	1.28477109344821
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/830	187/9376	1.26857805553766	CTSB/CCL2/XIAP/ITPR2/TAB3/JUN/IFNAR1/MAPK14/PKN1/CYBA/GABARAPL1/NFKBIA/CXCL3/GBP1/IFNAR2/MAPK3/GBP5/MAVS/ITPR3/TNF/CYBB	1.15611342129684
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	13/830	108/9376	1.35975011155734	UPF2/SEC13/KPNB1/UPF1/AHCTF1/RANGAP1/TPR/THOC2/XPO7/NUP62/KPNA6/DDX19B/POM121	1.17182576494538
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/830	60/9376	1.50618473895582	HSPB1/PLCG2/MAPKAPK2/AKT2/PPP3CB/MAPK14/KDR/MAPK3	1.22578181131794
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/830	33/9376	1.71157356699525	STX7/SNAP29/VAMP3/STX11/VTI1B	1.27607688689413
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/830	160/9376	1.27084337349398	HLA-DRA/HLA-DRB1/HLA-DRB5/VCAN/ITGAL/SELPLG/HLA-DQA1/ITGB8/HLA-DPA1/VSIR/HLA-G/CLDN5/HLA-DPB1/HLA-DQB1/CD4/PTPRF/JAM2/ICAM1	1.07683760378567
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/830	71/9376	1.43193619548617	PRL/PRLR/AKT2/MAPK14/MAPK3/SOCS6/FOXO3/CCND1/STAT5B	1.13850206967363
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	27/830	253/9376	1.205543121101	MYL9/PLCG2/CD14/IL1R1/EGFR/TNIP1/ILK/WIPI1/VCL/AKT2/ITPR2/TAB3/JUN/CBX3/MAPK14/ATG14/CRK/WIPI2/NFKBIA/FBXW11/ACTB/UBA52/MAPK3/FOXO3/ITPR3/TNF/RRAGA	1.03285084737609
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/830	91/9376	1.36549715344896	PLCG2/CD81/AKT2/PPP3CB/JUN/INPPL1/NFKBIA/LILRB1/IFITM1/MAPK3/LYN	1.09183492264204
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/830	193/9376	1.22914039578001	PLCG2/CXCL14/CCL2/AKT2/GNB5/GNB1/CRK/CCL18/CCL4L2/PRKACA/NFKBIA/CXCL3/GNG11/GNB2/PIK3R5/MAPK3/CCL3L1/FOXO3/LYN/RASGRP2/STAT5B	1.00237738859848
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/830	122/9376	1.29630653762591	RHEB/AKT2/CREB3/PDPK1/PRKAG2/PPP2R1A/CREB1/TSC2/CREB3L2/CAMKK2/INSR/FOXO3/EIF4EBP1/CCND1	1.0265961746567
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/830	44/9376	1.54041621029573	POLE3/PNKP/POLE4/POLD2/LIG1/XRCC1	1.11972295332094
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/830	73/9376	1.39270506684271	PLCG2/EGFR/CDK4/AKT2/PDPK1/MAPK3/FOXO3/CCND1/STAT5B	1.04968662736945
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/830	133/9376	1.27402844460549	EGFR/AKT2/DEPP1/MAPK14/CREBBP/PDPK1/PRKAG2/TGFBR1/GABARAPL1/CSNK1E/MAPK3/INSR/FOXO3/FBXO25/CCND1	0.991877936290775
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/830	18/9376	1.88273092369478	ACSL4/ACSF3/MECR	1.16819760966477
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/830	18/9376	1.88273092369478	HEXB/HEXA/ENGASE	1.16819760966477
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/830	18/9376	1.88273092369478	PRDX1/MTR/MTRR	1.16819760966477
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/830	36/9376	1.56894243641232	POLE3/RNASEH2C/POLE4/POLD2/LIG1	1.0658335351149
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/830	55/9376	1.43772179627601	PSAP/HEXB/PLPP3/ASAH1/HEXA/CERS4/SMPD4	1.01459216368366
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/830	27/9376	1.6735385988398	HSD17B12/ACAA1/ELOVL1/TECR	1.09220719072232
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/830	115/9376	1.27698271346255	AKT2/ITPR2/GNB5/CREB3/GNB1/CREB1/PRKACA/CREB3L2/GNG11/GNB2/PIK3R5/MAPK3/ITPR3	0.93135635815975
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/830	115/9376	1.27698271346255	EGFR/PDE4A/ITPR2/EGR1/CREB3/WNK1/CREB1/PRKACA/SP1/CREB3L2/MAPK3/MMP14/ITPR3	0.93135635815975
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/830	75/9376	1.35556626506024	ITPR2/CREB3/GPX3/CREB1/PRKACA/CREB3L2/ITPR3/CANX/GPX7	0.963450928253274
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/830	156/9376	1.23101637318505	CD81/EGFR/CDK4/YWHAG/PSME3/AKT2/IFNAR1/YWHAQ/YWHAH/CLDN5/PPP2R1A/NFKBIA/IFNAR2/MAPK3/MAVS/CCND1/TNF	0.906740136878691
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/830	56/9376	1.41204819277108	MGRN1/SPOP/PRKACA/CSNK1E/FBXW11/IQCE/CCND1	0.963778671619826
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/830	157/9376	1.22317550456603	SERPINE1/YWHAG/TCF7L2/WNT5A/YWHAQ/WNT4/YWHAH/TGFBR1/PPP2R1A/CSNK1E/FBXW11/NF2/TEAD1/ACTB/LATS2/PPP1CA/CCND1	0.878815451543386
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/830	37/9376	1.52653858677955	HBB/APOA1/ICAM1/LAMA4/TNF	1.0000555351582
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/830	37/9376	1.52653858677955	TCF7L2/CCDC6/TPR/MAPK3/CCND1	1.0000555351582
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/830	28/9376	1.61376936316695	ATP6V1E1/ATP6V0D1/ATP6V0A2/ATP6V1C1	1.01360352076924
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/830	19/9376	1.78363982244769	HEXB/GALNS/HEXA	1.06553623588998
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/830	117/9376	1.25515394912985	POLE3/BAZ2B/ZNHIT1/SMARCD2/BAZ1A/BAZ2A/INO80E/BRD8/SMARCA4/RSF1/ACTB/MTA3/MORF4L1	0.86547877849501
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/830	107/9376	1.26688435986938	AKT2/PPP3CB/ITPR2/CREB3/PHKG1/CREBBP/PRKAG2/CREB1/PRKACA/CREB3L2/PYGB/ITPR3	0.865250405774836
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/830	67/9376	1.3488221542888	PPP3CB/ITPR2/CREBBP/PRKACA/RPS6KA2/MAPK3/PPP1CA/ITPR3	0.892962428464968
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/830	77/9376	1.32035675168205	EGFR/CDK4/AKT2/RALA/TGFBR1/RALGDS/RALBP1/MAPK3/CCND1	0.879638765298811
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/830	68/9376	1.32898653437279	CD14/TCF7L2/AKT2/MAPK3/CSF1R/EIF4EBP1/CCND1/STAT5B	0.848491764825622
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/830	29/9376	1.5581221437474	CSNK1E/NF2/TEAD1/LATS2	0.938070268343373
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/830	49/9376	1.38323088271453	JUN/CREB3/MAOA/CREB1/PRKACA/CREB3L2	0.838167450306757
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/830	69/9376	1.30972585996159	PLCG2/AKT2/MAPK14/PDPK1/MAP2K7/MAPK3/LYN/TNF	0.804711848728997
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/830	69/9376	1.30972585996159	PPP3CB/JUN/CREB3/MAOA/CREB1/PRKACA/CREB3L2/PPP1CA	0.804711848728997
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/830	50/9376	1.35556626506024	AOC1/SAT1/PYCR2/MAOA/ALDH18A1/GAMT	0.785599297817082
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/830	143/9376	1.18493554638133	HLA-DRA/C1QB/C1QA/HLA-DRB1/C1QC/HLA-DRB5/HLA-DQA1/FCGR3A/HLA-DPA1/C1R/HLA-DPB1/HLA-DQB1/C1S/FCGR2A/TNF	0.694480787754412
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/830	21/9376	1.61376936316695	B3GAT3/B3GALT6/CHSY1	0.877477921885915
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/830	154/9376	1.1736504459396	MYL9/EGFR/PPP3CB/ITPR2/JUN/MYL6/PRKAG2/PRKACA/ACTB/PIK3R5/MAPK3/CAMKK2/PPP1R12C/PPP1CA/ITPR3/CCND1	0.677122031342708
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/830	12/9376	1.88273092369478	COQ4/VKORC1	0.953523721227514
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/830	31/9376	1.45759813447338	G6PD/PRPS2/GPI/PGLS	0.795277470537288
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/830	51/9376	1.32898653437279	PAFAH1B2/PLPP3/ENPP2/CHPT1/PAFAH1B3/LPCAT1	0.734145312745831
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/830	41/9376	1.3776079929474	EGFR/MMP2/CDK4/MAPK3/CCND1	0.755125586300822
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/830	62/9376	1.27539836766421	CRYAB/AKT2/PRKAG2/PRKACA/EIF4EBP2/INSR/FOXO3	0.678004115238848
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/830	62/9376	1.27539836766421	ADAM17/SPEN/APH1A/CTBP1/CREBBP/RBPJ/RFNG	0.678004115238848
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/830	94/9376	1.2017431427839	S100A9/CCL2/TAB3/JUN/MAPK14/NFKBIA/CXCL3/MAPK6/MAPK3/TNF	0.612611530736054
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/830	212/9376	1.11898158672426	FLT1/F2R/ITGAL/EGFR/APBB1IP/KRIT1/AKT2/PRKD2/RALA/MAPK14/CRK/VEGFB/RALGDS/ACTB/KDR/MAPK3/INSR/RASGRP2/CSF1R/AFDN/CNR1	0.546070086462483
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/830	170/9376	1.12963855421687	PLCG2/EGFR/CDK4/TCF7L2/AKT2/WNT5A/SMARCD2/WNT4/TGFBR1/SMARCA4/GSTO1/NFE2L2/KEAP1/ACTB/MGST3/MAPK3/CCND1	0.531577260301888
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/830	75/9376	1.20494779116466	IGFBP3/SERPINE1/CDK4/SIVA1/SHISA5/EI24/TSC2/CCND1	0.55533147838869
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/830	139/9376	1.13776545029037	KRT18/KRT19/EGFR/MMP2/AKT2/ITPR2/JUN/CREB3/CREB1/PRKACA/SP1/CREB3L2/MAPK3/ITPR3	0.509947520550638
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/830	44/9376	1.28368017524644	TAF2/TAF10/TAF3/TAF5/GTF2E2	0.587775121423031
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/830	86/9376	1.18217988231998	PLCG2/EGFR/AKT2/JUN/CRK/MAP2K7/MAPK3/EIF4EBP1/STAT5B	0.528913955329768
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/830	24/9376	1.41204819277108	B3GAT3/B3GALT6/EXT1	0.629860865488967
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/830	216/9376	1.09825970548862	CD14/CCL2/AKT2/PPP3CB/JUN/MAPK14/PDPK1/APOA1/POU2F1/CYBA/MIB2/MAP2K7/NFE2L2/NFKBIA/CXCL3/MAPK3/ICAM1/CCL3L1/LYN/TNF/CYBB	0.455300195710606
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/830	87/9376	1.16859160781055	MT-CO2/MT-CYB/MT-CO3/TPM1/MT-CO1/COX7A1/TPM2/SLC9A1/UQCRC1	0.492327774957654
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/830	87/9376	1.16859160781055	EGFR/TCF7L2/AKT2/JUN/RALA/TGFBR1/RALGDS/MAPK3/CCND1	0.492327774957654
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/830	99/9376	1.1410490446635	EGFR/MMP2/CDK4/AKT2/JUN/MAPK14/PRKACA/SP1/MAPK3/CCND1	0.439670379357288
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/830	110/9376	1.12963855421687	DCN/EMP3/FBN1/LTBP1/CREBBP/TGFBR1/PPP2R1A/SP1/MAPK3/TGIF2/TNF	0.426213904522425
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/830	78/9376	1.15860364535063	ENO2/CNOT6L/PARN/PATL1/PABPC4/EXOSC10/DHX36/EDC3	0.438337812018872
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/830	15/9376	1.50618473895582	HEXB/HEXA	0.611415992921569
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/830	89/9376	1.14233112224178	FN1/SPP1/ITGB8/COL6A3/ITGA1/LAMA3/HSPG2/LAMA4/COL6A2	0.42043648285513
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/830	89/9376	1.14233112224178	EGFR/ITPR2/MAP3K2/GJA1/TUBB4B/TUBB6/PRKACA/MAPK3/ITPR3	0.42043648285513
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	12/830	122/9376	1.11111988939364	CDK4/AKT2/PPP3CB/JUN/MAPK14/PDPK1/PPP2R1A/MAP2K7/NFKBIA/CD4/MAPK3/TNF	0.384990673151486
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/830	200/9376	1.07315662650602	IL1R1/F2R/RAB1A/TAB3/JUN/MAPK14/MYO1G/WIPF2/CLDN5/TUBB4B/TUBB6/NFKBIA/ACTB/MYO10/MYO5A/MAPK3/GAPDH/FCGR2A/TNF	0.325900634533592
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/830	69/9376	1.14601012746639	CTSB/PPP3CB/ITPR2/CREB1/PRKACA/PTGER4/ITPR3	0.379355083948127
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/830	80/9376	1.12963855421687	PLCG2/EGFR/AKT2/AXL/KDR/MAPK3/FOXO3/EIF4EBP1	0.36288946052234
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/830	16/9376	1.41204819277108	HEXB/HEXA	0.514059418696516
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/830	49/9376	1.15269240226211	GALNT15/PLOD3/GALNT10/COLGALT1/RFNG	0.333954822687345
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/830	238/9376	1.04420370557862	FLT1/PLCG2/EGFR/AKT2/RAB5C/GNB5/GNB1/RALA/VEGFB/PRKACA/RALGDS/RALBP1/RAB5B/RASA1/KDR/GNG11/GNB2/MAPK3/INSR/RASGRP2/CSF1R/AFDN	0.215260735295076
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/830	149/9376	1.06140535295545	PLCG2/F2R/EGFR/PLPP3/RHEB/AKT2/DGKA/RALA/AGPAT1/TSC2/RALGDS/PIK3R5/MAPK3/INSR	0.235457401073692
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/830	83/9376	1.08880824502831	CBX3/PHC2/CREBBP/USP16/CBX6/MBD6/CBX7/PHF19	0.253254753498797
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/830	72/9376	1.09825970548862	ZNFX1/PIN1/MAPK14/IFIH1/NFKBIA/MAVS/TNF	0.260825528233022
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/830	39/9376	1.15860364535063	AHCYL1/MTR/MTHFR/GCSH	0.309303638730965
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/830	298/9376	1.02349801892132	PRL/IL1RL1/PRLR/EBI3/CXCL14/IL1R1/CCL2/IL1R2/RELL1/CSH1/IFNAR1/TGFBR1/CCL18/CSF2RB/CCL4L2/TNFSF12/CD4/CXCL3/IL6ST/IFNAR2/IL12RB1/TNFRSF11B/CCL3L1/CSF1R/GDF15/TNF/INHA	0.12846580189894
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/830	41/9376	1.10208639435792	GRHPR/MAOA/GAMT/GCSH	0.20414834916802
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/830	154/9376	1.02694414019715	TPM1/AKT2/CREB3/MAPK14/TPM2/PPP2R1A/CREB1/ATP2B1/PRKACA/CREB3L2/SLC9A1/PIK3R5/MAPK3/PPP1CA	0.105064348348544
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/830	75/9376	1.05432931726908	XIAP/AKT2/SLC31A1/PDPK1/GSTO1/MGST3/MAPK3	0.147212028524107
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/830	98/9376	1.0374231620359	PLCG2/ITPK1/PIK3C2A/ITPR2/DGKA/PI4KA/SYNJ2/INPPL1/ITPR3	0.116056528016308
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/830	166/9376	1.02075772971404	MYL9/AKT2/PPP3CB/ITPR2/CREB3/SRF/CREB1/ATP2B1/ADRA2C/CREB3L2/PIK3R5/MAPK3/INSR/PPP1CA/ITPR3	0.0840905749312054
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/830	19/9376	1.18909321496512	OGDH/GCSH	0.257115152567076
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/830	178/9376	1.01540544199269	NOTUM/DKK1/CTBP1/TCF7L2/WNT5A/PPP3CB/JUN/WNT4/CREBBP/SFRP1/DAAM1/PRKACA/CSNK1E/FBXW11/APCDD1/CCND1	0.0646667003941678
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/830	42/9376	1.0758462421113	AOC1/HADHA/MAOA/KYAT3	0.153521093493035
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/830	133/9376	1.01922275568439	PLCG2/ITGAL/FCGR3A/PPP3CB/IFNAR1/HLA-G/SH3BP2/IFNAR2/MAPK3/ICAM1/MICA/TNF	0.0695790076300506
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/830	168/9376	1.00860585197935	FTH1/FTL/CHMP4B/XIAP/CHMP1A/VPS4A/IFNAR1/STAT6/CHMP6/PYGB/IFNAR2/CHMP3/TNF/CYBB/STAT5B	0.0350759221615539
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/830	168/9376	1.00860585197935	PRL/PRLR/EGFR/AKT2/CSH1/IFNAR1/STAT6/CREBBP/CSF2RB/IL6ST/IFNAR2/IL12RB1/SOCS6/CCND1/STAT5B	0.0350759221615539
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/830	54/9376	1.04596162427488	AHCYL1/MTR/TST/CISD1/KYAT3	0.105555517416326
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/830	100/9376	1.01667469879518	CXCL14/CCL2/CCL18/CCL4L2/CXCL3/IL6ST/CCL3L1/CSF1R/TNF	0.0522421290810234
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/830	43/9376	1.0508265620622	HADHA/ACAA1/ACSL4/ECI1	0.104101639622124
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/830	89/9376	1.01540544199269	TRAK2/GNB5/GNB1/GABARAPL1/PRKACA/GNG11/GNB2/SLC38A5	0.0455066309196441
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/830	101/9376	1.0066086126685	TCF7L2/WNT5A/CREB3/WNT4/CREBBP/CREB1/PRKACA/CREB3L2/MAPK3	0.0208092901848252
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/830	170/9376	0.996739900779589	MYL9/CDK4/JUN/MYL6/CLDN5/PRKAG2/PPP2R1A/MAP2K7/PRKACA/NF2/ACTB/SYMPK/JAM2/AFDN/CCND1	-0.0133678952404804
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/830	90/9376	1.00412315930388	EGFR/AKT2/PPP3CB/JUN/MAPK14/NFKBIA/CD4/MAPK3	0.0122484256384674
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/830	45/9376	1.00412315930388	ABCC4/ABCB10/ABCA7/ABCB8	0.00864003530310886
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/830	93/9376	0.971732089648918	FN1/CDK4/XIAP/AKT2/NFKBIA/LAMA3/LAMA4/CCND1	-0.0853756935150065
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/830	46/9376	0.982294394971189	FTH1/FTL/UROS/HMOX2	-0.0375138904646711
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/830	22/9376	1.02694414019715	AOC1/MAOA	0.0394294053482271
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/830	70/9376	0.968261617900172	AKT2/ACSL4/PRKAG2/NFKBIA/CAMKK2/TNF	-0.0830606872903797
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/830	70/9376	0.968261617900172	AKT2/JUN/CREBBP/CRK/ELOB/MAPK3	-0.0830606872903797
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/830	83/9376	0.952707214399768	PRDX1/ACAA1/ACSL4/IDH1/HMGCL/PEX19/PEX26	-0.134864986416979
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/830	83/9376	0.952707214399768	POLR2E/POLR3D/POLR1C/CCL4L2/NFKBIA/DDX41/MAVS	-0.134864986416979
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/830	23/9376	0.982294394971189	B3GALNT2/RXYLT1	-0.0264936907623329
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/830	23/9376	0.982294394971189	POLD2/LIG1	-0.0264936907623329
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/830	60/9376	0.941365461847389	ITPR2/PPP2R1A/MAPK3/LYN/ITPR3	-0.141989959102204
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/830	48/9376	0.941365461847389	HADHA/ACAA1/HMGCL/ACSF3	-0.126917964649548
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/830	36/9376	0.941365461847389	AGL/GPI/PYGB	-0.109843550207135
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/830	97/9376	0.931660663271643	GNB5/GNB1/CREB1/PRKACA/GNG11/GNB2/MAPK3/ITPR3	-0.210838190046174
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/830	134/9376	0.927315231073548	CALD1/MYL9/RAMP1/ADM/ITPR2/MYL6/PRKACA/MAPK3/PPP1R12C/PPP1CA/ITPR3	-0.264092502157954
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/830	217/9376	0.937027372161457	KPNB1/EGFR/XIAP/AKT2/JUN/CREB3/GSTO1/CREB1/PRKACA/KPNA6/CREB3L2/RPS6KA2/MGST3/MAPK3/EIF4EBP1/CCND1/KLF4/STAT5B	-0.292483178906526
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/830	158/9376	0.929449443342992	CDKN1C/CDK4/YWHAG/SMC1A/YWHAQ/YWHAH/CREBBP/PPP2R1A/ANAPC15/ORC3/MAU2/ANAPC11/CCND1	-0.278710850451992
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/830	99/9376	0.912839235730802	PLCG2/IL1R1/ITPR2/MAPK14/PRKACA/PTGER4/PPP1CA/ITPR3	-0.271692774543304
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/830	99/9376	0.912839235730802	TPM1/ITGB8/TTN/ITGA1/TPM2/PRKAG2/ACTB/TNF	-0.271692774543304
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/830	38/9376	0.891819911223843	PDPK1/MAPK3/INSR	-0.208235819874002
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/830	63/9376	0.896538535092752	HADHA/KMT5B/DOT1L/PLOD3/COLGALT1	-0.256771806569833
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/830	12/9376	0.941365461847389	NPC1	-0.0633368804819005
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/830	76/9376	0.891819911223843	PLTP/ILK/ACAA1/ACSL4/PDPK1/APOA1	-0.295090953379822
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/830	76/9376	0.891819911223843	PLCG2/EGFR/CDK4/AKT2/MAPK3/CCND1	-0.295090953379822
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/830	26/9376	0.868952734012975	APOA1/SLC5A6	-0.208522092064252
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/830	52/9376	0.868952734012975	CYP11A1/PRKACA/HSD3B1/INSR	-0.295305641867332
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/830	65/9376	0.868952734012975	SPP1/AKT2/ITPR2/MAPK3/ITPR3	-0.330392149873791
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/830	115/9376	0.88406495547407	ITPR2/GNB5/GNB1/MAOA/PRKACA/GNG11/GNB2/MAPK3/ITPR3	-0.389832417709199
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/830	78/9376	0.868952734012975	PLCG2/ITPK1/PIK3C2A/PI4KA/SYNJ2/INPPL1	-0.362179392010919
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/830	13/9376	0.868952734012975	POLM	-0.147344988560945
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/830	103/9376	0.87738916832378	UPF2/UPF1/CPSF2/PPP2R1A/PABPC4/SYMPK/DDX19B/PPP1CA	-0.389924533187305
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/830	27/9376	0.836769299419902	HADHA/HMGCL	-0.264694176736601
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/830	66/9376	0.855786783497627	HSD11B1/HSD17B12/COMT/CYP11A1/HSD3B1	-0.366391534576204
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/830	116/9376	0.876443705857914	PPP3CB/ITPR2/GNB5/GNB1/PRKACA/GNG11/GNB2/MAPK3/ITPR3	-0.417283887136783
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/830	41/9376	0.82656479576844	BABAM2/NBN/POLD2	-0.346828887964782
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/830	226/9376	0.899712122827593	MYL9/F2R/FXYD1/PDE4A/AKT2/JUN/CREB3/CREBBP/CREB1/ATP2B1/PRKACA/ABCC4/NFKBIA/CREB3L2/SLC9A1/MAPK3/PPP1CA/AFDN	-0.475592887636633
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/830	105/9376	0.860676993689042	TPM1/ITGB8/TTN/ITGA1/TPM2/PRKACA/ACTB/TNF	-0.447401500428315
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/830	28/9376	0.806884681583477	FPGS/PCBD2	-0.318918438110792
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/830	14/9376	0.806884681583477	CHST2	-0.225340712993353
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/830	93/9376	0.850265578442803	CST3/LYZ/ITPR2/ATP2B1/PRKACA/SLC9A1/ITPR3	-0.452232935676648
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/830	43/9376	0.788119921546652	PLPP3/APOA1/AGPAT1	-0.433967254036659
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/830	232/9376	0.876443705857914	FN1/MYL9/F2R/ITGAL/EGFR/ITGB8/VCL/AKT2/ITGA1/DIAPH2/CRK/ACTB/SLC9A1/MAPK3/PPP1R12C/PPP1CA/CFL2/LIMK2	-0.593859895888006
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/830	184/9376	0.859507595599791	MYL9/PLCG2/ILK/WNT5A/PPP3CB/WNT4/PDPK1/SEMA3B/PLXNA3/RASA1/MAPK3/SEMA5A/CFL2/LIMK2	-0.599791060972442
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/830	71/9376	0.795520108603428	G6PD/EGFR/AKT2/IDH1/MAPK3	-0.538970296989364
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/830	110/9376	0.821555312157722	AKT2/MAPK14/ANAPC15/PRKACA/RPS6KA2/ANAPC11/MAPK3/AURKA	-0.586674293044892
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/830	148/9376	0.839596222728753	EGFR/CDK4/TCF7L2/AKT2/WNT5A/JUN/WNT4/NFKB2/SP1/MAPK3/CCND1	-0.612963897348939
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/830	16/9376	0.706024096385542	MAOA	-0.366755842578801
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/830	136/9376	0.830616583982991	CDK4/AKT2/JUN/IFNAR1/IFIH1/NFKBIA/IFNAR2/MAVS/CCND1/STAT5B	-0.620079817293691
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/830	59/9376	0.76585664692669	MGLL/AKT2/PRKACA/INSR	-0.562228726467673
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/830	86/9376	0.788119921546652	ITGB8/TCF7L2/ITGA1/GJA1/DSP/ACTB	-0.61514108431309
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/830	73/9376	0.773725037134841	EGFR/CDK4/AKT2/MAPK3/CCND1	-0.604824899606419
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/830	125/9376	0.813339759036145	AKT2/SPTSSA/MAPK14/ASAH1/PDPK1/PPP2R1A/MAPK3/CERS4/TNF	-0.65472018182598
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/830	32/9376	0.706024096385542	HADHA/ACSS1	-0.519114964430791
NA	NA	hsa04517	IgSF CAM signaling	23/830	299/9376	0.868952734012975	MYL9/PLCG2/ITGAL/VCL/DYNLL2/AKT2/MAPK14/MYL6/PDPK1/TUBB4B/TUBB6/PMP22/PLXNA3/ACTB/RASA1/KDR/PTPRF/JAM2/MAPK3/ICAM1/CLMP/LYN/AFDN	-0.717687911805429
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/830	201/9376	0.843013846430498	IGFBP3/FLT1/NUPR1/CD14/ATF1/IL1R2/HPGD/PBX3/AFF1/DOT1L/MAF/NR4A3/SP1/CSF1R/WT1	-0.701131664285423
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/830	47/9376	0.721045885670341	MAPK3/INSR/TNF	-0.59745801802323
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/830	154/9376	0.806884681583477	COQ4/UROS/AK3/PMM1/FLAD1/PDXK/FPGS/RDH13/COASY/PNPO/VKORC1	-0.753022176142702
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/830	76/9376	0.743183259353202	ITPR2/PRKACA/ACTB/SLC9A1/ITPR3	-0.700538312537092
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/830	63/9376	0.717230828074201	PTGDS/HPGD/GPX4/PTGES	-0.70177965470269
NA	NA	hsa04519	Cadherin signaling	31/830	404/9376	0.866801860908982	KRT18/KRT8/KRT19/KRT7/EGFR/APH1A/YWHAG/TCF7L2/VCL/WNT5A/YWHAQ/MAPK14/WNT4/MYO1G/YWHAH/VIM/CREBBP/CDH11/GJA1/DSP/DAAM1/NFKBIA/NF2/TEAD1/ACTB/KDR/LATS2/MAPK3/PPP1CA/AFDN/LHFPL6	-0.852879051983032
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/830	91/9376	0.744816629153979	PDE4A/GNB5/GNB1/PRKACA/GNG11/GNB2	-0.762299003803617
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/830	35/9376	0.645507745266781	PMM1/ENOSF1	-0.654767820207422
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/830	195/9376	0.811022551745443	PLCG2/ITGAL/SELPLG/FCGR3A/AKT2/MAPK14/HDAC7/C5AR1/CYBA/CLCN3/ACTB/MAPK3/FCGR2A/CYBB	-0.83104689764741
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/830	65/9376	0.69516218721038	PLPP3/MGLL/DGKA/AGPAT1	-0.768547283850688
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/830	36/9376	0.627576974564926	GALNT15/GALNT10	-0.697682092868151
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/830	37/9376	0.61061543471182	COMT/MAOA	-0.73955869446022
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/830	67/9376	0.674411077144398	ENO2/ACSS1/GPI/GAPDH	-0.833486840384922
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/830	21/9376	0.537923121055651	COASY	-0.660610131133778
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/830	38/9376	0.594546607482562	NMRK1/NNMT	-0.780457111532456
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/830	191/9376	0.768863937425093	GNB5/CREB3/GNB1/HDAC7/MAOA/CREB1/PRKACA/CREB3L2/GNG11/GNB2/MAPK3/CAMKK2/PPP1CA	-1.00574539837992
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/830	243/9376	0.790282116118796	SLU7/ISY1/TXNL4A/CTNNBL1/SNRNP200/RBMX2/SF1/SART1/DDX46/THOC2/PUF60/TCERG1/XAB2/PRPF4/HNRNPM/PQBP1/PRPF6	-1.03222676298711
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/830	23/9376	0.491147197485594	DHDDS	-0.761419266465386
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/830	23/9376	0.491147197485594	ATP6AP2	-0.761419266465386
NA	NA	hsa04081	Hormone signaling	15/830	219/9376	0.773725037134841	PRL/RAMP1/PRLR/SLC40A1/CSH1/DIO2/GNB5/GNB1/PRKACA/ADRA2C/NPR3/GNG11/GNB2/INSR/STAT5B	-1.05590584215672
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/830	86/9376	0.656766601288876	CREB3/CREB1/PRKACA/CREB3L2/ITPR3	-0.996492764194042
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/830	144/9376	0.706024096385542	KAT6A/AKT2/WNT5A/MAPK14/WNT4/RIF1/IL6ST/MAPK3/KLF4	-1.10786877548033
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/830	104/9376	0.651714550509731	PLPP3/PCYT1A/DGKA/AGPAT1/CHPT1/LPCAT1	-1.11303425221315
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/830	26/9376	0.434476367006488	ACAA1	-0.899859834353655
NA	NA	hsa04382	Cornified envelope formation	14/830	217/9376	0.728799067236689	S100A6/KRT18/KRT8/KRT19/KRT7/S100A9/ELOVL1/CLDN5/DSP/PPP2R1A/S100A13/COL17A1/LAMA3/PRSS8	-1.25962205579864
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/830	63/9376	0.537923121055651	TCF7L2/WNT5A/WNT4	-1.14678750283555
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/830	47/9376	0.480697257113561	GRHPR/ACSS1	-1.11223162370103
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/830	29/9376	0.389530535936851	GNB1	-1.02605363428893
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/830	183/9376	0.679017710185002	WDR43/LSG1/RRP7A/TCOF1/UTP4/FCF1/IMP4/REXO1/DROSHA/GNL2/FBL	-1.36653646762362
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/830	82/9376	0.55104319717896	GSTO1/RRM1/UCKL1/MGST3	-1.27248710160596
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/830	31/9376	0.364399533618344	HADHA	-1.10463459768701
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/830	32/9376	0.353012048192771	GALK1	-1.14247842581694
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/830	32/9376	0.353012048192771	XIAP	-1.14247842581694
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/830	70/9376	0.484130808950086	HSD11B1/GSTO1/MGST3	-1.35005147476532
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/830	102/9376	0.553744389321994	RAB11A/ITPR2/ATP2B1/SLC9A1/ITPR3	-1.41219109859189
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/830	150/9376	0.602473895582329	EGFR/TCF7L2/AKT2/WNT5A/WNT4/TGFBR1/MAPK3/CCND1	-1.52949406943648
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/830	73/9376	0.464235022280904	MAOA/GSTO1/MGST3	-1.43208066309435
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/830	36/9376	0.313788487282463	FGGY	-1.28552063552917
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/830	38/9376	0.297273303741281	CD4	-1.35267840319091
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/830	59/9376	0.382928323463345	RRM1/UCKL1	-1.48172227946975
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/830	79/9376	0.428976666158304	HSD11B1/GSTO1/MGST3	-1.58832446567834
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/830	85/9376	0.398695960311836	AK3/RRM1/UCKL1	-1.73546394122405
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/830	103/9376	0.43869458416189	COL6A3/SLC7A8/COL17A1/COL6A2	-1.78505234206507
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/830	68/9376	0.332246633593196	ALDH1A2/RDH13	-1.72220797246597
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/830	48/9376	0.235341365461847	AKT2	-1.65514934721054
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/830	90/9376	0.376546184738956	PRKACA/ABCC4/SLC9A1	-1.85205739881398
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/830	128/9376	0.441265060240964	PDE4A/AK3/PAPSS2/PRPS2/RRM1	-1.98349059104238
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/830	54/9376	0.209192324854975	CENPX	-1.81616978607002
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/830	254/9376	0.533687505929229	FLT1/PLCG2/F2R/EGFR/PPP3CB/ITPR2/PHKG1/VEGFB/ATP2B1/PRKACA/KDR/ITPR3	-2.34796768975753
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/830	86/9376	0.262706640515551	PRKACA/ITPR3	-2.1405478038369
NA	NA	hsa04082	Neuroactive ligand signaling	7/830	199/9376	0.397360295453169	TAC3/GNB5/GNB1/PRKACA/ADRA2C/GNG11/GNB2	-2.67779393761397
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/830	323/9376	0.384706628371069	TIMP3/TPM1/PLCG2/MARCKS/DICER1/EGFR/VIM/CREBBP/CRK/MAPK3/CCND1	-3.5069572974508
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/830	370/9376	0.396900032562683	PRL/NPW/PRLR/F2R/TAC3/ADM/CSH1/PGRMC1/C5AR1/ADRA2C/PTGER4/RXFP1/CNR1	-3.68864988982195
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/830	449/9376	0.0503179756889473	GNB1/PRKACA	-6.42675672939882