category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	101/1060	222/9376	4.02420533741288	RPL13A/RPL10/RPS8/RPS26/RPL18A/RPS27/RPS28/RPL28/RPS11/RPL13/RPL37A/RPL36/RPL8/RPS15/RPS14/RPS2/RPL41/RPL11/RPL18/RPLP0/RPL7/RPL23/RPL35/RPS5/RPS18/RPL29/RPS27A/RPLP2/RPS9/RPL3/RPL19/RPL21/RPL35A/RPL27A/RPS16/RPS12/RPS20/RPL34/RPL5/RPS6/RPS3/RPL15/RPS4X/RPL31/UBA52/RPSA/RPL12/RPS3A/RPL10A/RPLP1/RACK1/RPS24/RPS29/RPS19/RPL6/RPS13/RPL7A/RPL37/RPL30/RPS25/RPS23/RPL22/RPL24/RPL9/MRPS10/MRPL22/RPL32/MRPL17/MRPS15/RPL36AL/RPL14/MRPL27/MRPS16/MRPL16/MRPL14/MRPS26/RPL39/RPL4/MRPL46/FAU/MRPL52/MRPL49/MRPL1/MRPL43/MRPS27/MRPS7/RPS15A/MRPL11/RPL26L1/MRPS12/MRPS33/RPS7/MRPL4/RPL38/MRPL36/MRPL21/MRPL40/MRPS18A/RPS4Y1/MRPL23/MRPL12	16.2803463254211
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	84/1060	238/9376	3.12186459489456	RPL13A/RPL10/RPS8/RPS26/RPL18A/RPS27/RPS28/RPL28/RPS11/RPL13/RPL37A/RPL36/RPL8/RPS15/RPS14/RPS2/RPL41/RPL11/RPL18/RPLP0/RPL7/RPL23/RPL35/RPS5/RPS18/RPL29/RPS27A/RPLP2/RPS9/RPL3/RPL19/RPL21/RPL35A/RPL27A/RPS16/RPS12/RPS20/RPL34/RPL5/RPS6/RPS3/RPL15/RPS4X/RPL31/UBA52/RPSA/RPL12/RPS3A/RPL10A/RPLP1/RPS24/RPS29/RPS19/RPL6/RPS13/EGFR/RPL7A/C1R/RPL37/RPL30/RPS25/RPS23/RPL22/RPL24/CFD/RPL9/NFKBIB/RPL32/RPL36AL/RPL14/C1QB/RPL39/RPL4/IRF3/FAU/FGG/IKBKG/RPS15A/RPL26L1/STAT1/VWF/RPS7/RPL38/RPS4Y1	11.837551963977
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	59/1060	235/9376	2.22073063026897	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/RPS6/COX4I1/ATP5ME/ATP5F1E/MT-ATP6/NDUFA5/PRKACA/COX6C/ACTG1/NDUFS4/MT-ND4/SMARCB1/UQCRFS1/NDUFB6/COA3/NDUFA9/COA5/NDUFV3/ATP5F1D/CREB1/SMARCC1/NDUFA10/SMARCD2/CPT2/SMARCC2/ARID1A/COX16/NDUFA2/MT-ND1/NDUFAB1/COX14/CREB3/COX17/BMP8B/TSC2/CREB3L1/PRKAG1/NDUFC1/SMARCD1/CNR1/COX18/NDUFAF1/SDHA/NDUFB4/COX7A2L/ATP5MC1/UQCRB/COX20/MAP3K5/UQCRQ/ATP5PB/NDUFA8/PRKACB/ATP5MC3	6.76609745904175
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	67/1060	308/9376	1.92413624111737	MT-CYB/MT-CO2/MT-CO3/MT-ND3/TGM2/COX7A1/POLR2L/COX4I1/ATP5F1E/MT-ATP6/NDUFA5/PSMA7/POLR2J/DCTN5/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/VDAC3/NDUFA9/NDUFV3/BECN1/ATP5F1D/CREB1/NDUFA10/ATG101/POLR2D/PSMB4/PSMB7/NDUFA2/MT-ND1/NDUFAB1/CREB3/TUBA3E/TRAF2/PSMD3/HDAC2/KLC1/CREB3L1/NDUFC1/CREBBP/WIPI2/SDHA/NDUFB4/COX7A2L/ATP5MC1/UQCRB/MAP3K5/HDAC1/PSMD2/ADRM1/UQCRQ/PSMB5/SLC25A6/PIK3R4/RCOR1/GPX8/ATP5PB/POLR2F/ATG14/HIP1/DCTN2/CLTB/NDUFA8/GPX3/ATP5MC3	5.88758154067911
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	37/1060	138/9376	2.37156138911676	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/ATP5ME/ATP5F1E/MT-ATP6/NDUFA5/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/NDUFA9/NDUFV3/ATP5F1D/NDUFA10/NDUFA2/MT-ND1/NDUFAB1/COX17/ATP6V0E2/NDUFC1/SDHA/NDUFB4/COX7A2L/ATP5MC1/UQCRB/ATP6V0D1/UQCRQ/ATP6V0B/ATP5PB/NDUFA8/ATP5MC3/ATP6V1E1	5.79491600634408
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	55/1060	268/9376	1.81526330611095	MT-CYB/MT-CO2/MT-CO3/MT-ND3/RPS27A/COX7A1/UBA52/COX4I1/ATP5F1E/MT-ATP6/NDUFA5/PSMA7/PRKACA/MFN2/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/MAOA/VDAC3/NDUFA9/NDUFV3/ATP5F1D/KEAP1/SLC39A7/NDUFA10/PSMB4/PSMB7/NDUFA2/MT-ND1/NDUFAB1/TUBA3E/PSMD3/ATF6/KLC1/MAOB/NDUFC1/SDHA/NDUFB4/COX7A2L/ATP5MC1/UQCRB/MAP3K5/PSMD2/ADRM1/UQCRQ/UBE2L3/PSMB5/SLC25A6/ATP5PB/NDUFA8/CALM2/PRKACB/ATP5MC3	4.83431685940867
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	45/1060	205/9376	1.94164749194662	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/GAPDH/COX4I1/ATP5F1E/MT-ATP6/NDUFA5/MMP2/GFPT1/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/VDAC3/COL1A1/NDUFA9/NDUFV3/ATP5F1D/NDUFA10/CPT2/PDHA1/NDUFA2/MT-ND1/NDUFAB1/NDUFC1/G6PD/AKT2/SDHA/NDUFB4/SLC2A1/COX7A2L/ATP5MC1/UQCRB/UQCRQ/PARP1/INSR/PTPA/SLC25A6/ATP5PB/NDUFA8/ATP5MC3	4.86674137989497
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	71/1060	388/9376	1.6185956039681	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/DKK1/GAPDH/COX4I1/ATP5F1E/MT-ATP6/WNT4/NDUFA5/PSMA7/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/VDAC3/NDUFA9/CAPN1/NDUFV3/BECN1/ATP5F1D/APH1A/WNT5A/SLC39A7/NDUFA10/ATG101/PSMB4/CSNK2A2/PPP3CB/PSMB7/NDUFA2/MT-ND1/NDUFAB1/TUBA3E/CSNK2B/IKBKG/TRAF2/PSMD3/ATF6/DVL2/KLC1/FADD/NDUFC1/BACE1/AKT2/WIPI2/SDHA/NDUFB4/COX7A2L/ATP5MC1/MAP2K2/UQCRB/MAP3K5/PSMD2/ADRM1/UQCRQ/INSR/PSMB5/SLC25A6/APH1B/PIK3R4/HSD17B10/WNT10B/ATP5PB/ATG14/NDUFA8/CALM2/ATP5MC3	4.4429608951585
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	54/1060	275/9376	1.73689193825043	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/CAV1/ATP5F1E/MT-ATP6/NDUFA5/PSMA7/PRKACA/COX6C/NDUFS4/MT-ND4/UQCRFS1/NOTCH1/NDUFB6/C1QB/VDAC3/NDUFA9/NDUFV3/ATP5F1D/CREB1/NDUFA10/PSMB4/CSNK2A2/PPP3CB/PSMB7/NDUFA2/MT-ND1/NDUFAB1/CREB3/TUBA3E/CSNK2B/PSMD3/KLC1/CREB3L1/NDUFC1/SDHA/NDUFB4/COX7A2L/ATP5MC1/UQCRB/PSMD2/ADRM1/UQCRQ/PSMB5/SLC25A6/CAV2/ATP5PB/NDUFA8/PRKACB/ATP5MC3	4.42799299856854
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	61/1060	333/9376	1.62030709955238	FN1/HLA-E/COL6A3/EGFR/WNT4/FOXO1/ITGA1/HLA-C/ITGB8/PRKACA/HLA-G/LAMA4/COL6A2/NOTCH1/TNXB/COL1A1/CREB1/WNT5A/CCND3/ITGB1/COL4A2/PPP2R5A/IRF3/TRADD/CREB3/IKBKG/COL4A1/MFNG/DVL2/HDAC2/FADD/TSC2/LAMB3/PRKCI/ATP6V0E2/CREB3L1/ITGB7/CREBBP/RFNG/STAT1/AKT2/VWF/MAP2K2/PKM/ATP6V0D1/CDK4/HDAC1/PPP2R5B/TADA3/VTN/ATP6V0B/THBS3/WNT10B/HLA-A/TCF7L2/ITGA3/PRKACB/PPP2R1A/TUBG1/LAMA3/ATP6V1E1	4.11484929194923
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1060	203/9376	1.7864857328748	FN1/FLT1/MYL9/COL6A3/CAV1/EGFR/KDR/ITGA1/ITGB8/LAMA4/ACTG1/COL6A2/ARHGAP5/PDPK1/TNXB/COL1A1/CCND3/ITGB1/COL4A2/FLNA/EMP2/CRKL/PIP5K1A/COL4A1/VEGFB/TLN1/LAMB3/PAK4/ITGB7/PARVA/AKT2/VWF/CRK/SHC1/VTN/PPP1R12C/CAV2/THBS3/VCL/ITGA3/LAMA3	4.04449684976423
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	65/1060	368/9376	1.56234618539787	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/ATP5F1E/MT-ATP6/NDUFA5/PSMA7/DCTN5/COX6C/ACTG1/NDUFS4/MT-ND4/UQCRFS1/POM121/NDUFB6/NDUFA9/NDUFV3/BECN1/ATP5F1D/NDUFA10/ATG101/GLE1/PSMB4/PPP3CB/PSMB7/NDUFA2/MT-ND1/NDUFAB1/TUBA3E/TRAF2/PSMD3/HDAC6/ATF6/WDR41/KLC1/RAE1/NDUFC1/VCP/UBQLN4/WIPI2/SDHA/NDUFB4/COX7A2L/VAPB/ATP5MC1/UQCRB/MAP3K5/OPTN/CCS/TOMM40/PSMD2/ADRM1/UQCRQ/PSMB5/PIK3R4/GPX8/ATP5PB/ATG14/DCTN2/NDUFA8/GPX3/ATP5MC3	3.92911558236179
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	44/1060	224/9376	1.73746630727763	HLA-DRB5/HLA-DRA/HLA-E/IL1R1/HLA-DPB1/IL1R2/HLA-C/RANBP3/CDC16/PRKACA/HLA-G/RELB/HLA-DRB1/VDAC3/CREB1/CCND3/NFATC2/MAP3K3/HLA-DMB/NFATC3/PPP3CB/KAT5/TRRAP/CREB3/IKBKG/TLN1/STAT5B/CREB3L1/HLA-DPA1/CREBBP/AKT2/SLC2A1/MAP2K2/CDK4/CD3D/FDPS/SLC25A6/SRF/HLA-A/CD3E/IL2RB/CD3G/PRKACB/NFATC4	3.98831560144167
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	27/1060	116/9376	2.05881587508133	GAPDH/TPI1/HK1/DLST/PGD/GOT2/PDHA1/ACAT1/SUCLG1/ALDH6A1/G6PD/ECHS1/ESD/IDH3G/PFKP/SDHA/PKM/TKT/ACADS/MDH2/PRPS2/SHMT2/OGDH/IDH2/ME3/ENO2/GCSH	4.09661617978316
NA	NA	hsa04518	Integrin signaling	33/1060	154/9376	1.89541778975741	FN1/FLT1/FERMT2/COL6A3/FBN1/EGFR/KDR/ITGA1/ITGB8/LAMA4/ACTG1/COL6A2/TNXB/COL1A1/CCND3/ITGB1/COL4A2/FLNA/LIMS2/FGG/COL4A1/VEGFB/TLN1/LAMB3/ITGB7/PARVA/AKT2/VWF/VTN/THBS3/VCL/ITGA3/LAMA3	3.99995265131531
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/1060	227/9376	1.67553819300141	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/ATP5F1E/EGFR/MT-ATP6/NDUFA5/SLC26A2/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/PDPK1/VDAC3/NDUFA9/NDUFV3/ATP5F1D/KEAP1/NDUFA10/GSTA1/NDUFA2/MT-ND1/NDUFAB1/IKBKG/PTPN11/NDUFC1/AKT2/SDHA/NDUFB4/COX7A2L/ATP5MC1/MAP2K2/UQCRB/MAP3K5/UQCRQ/SLC25A6/ATP5PB/NDUFA8/ATP5MC3	3.67838644151585
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1060	32/9376	3.04056603773585	BECN1/ATG10/ATG101/GABARAP/WIPI2/ATG9B/IGBP1/PIK3R4/GABARAPL2/ATG4D/ATG4B	4.12800827259028
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	78/1060	480/9376	1.43735849056604	MT-CYB/MT-CO2/MT-CO3/MT-ND3/RPS27A/COX7A1/DKK1/UBA52/COX4I1/ATP5F1E/MT-ATP6/WNT4/NDUFA5/PSMA7/DCTN5/MFN2/COX6C/NDUFS4/MT-ND4/UQCRFS1/NDUFB6/VDAC3/NDUFA9/CAPN1/NDUFV3/BECN1/ATP5F1D/WNT5A/NDUFA10/ATG101/PSMB4/CSNK2A2/PPP3CB/PSMB7/NDUFA2/MT-ND1/NDUFAB1/TUBA3E/CSNK2B/TRAF2/PSMD3/ATF6/DVL2/WDR41/KLC1/FADD/NDUFC1/VCP/WIPI2/SDHA/NDUFB4/COX7A2L/VAPB/ATP5MC1/MAP2K2/UQCRB/MAP3K5/OPTN/CCS/TOMM40/PSMD2/ADRM1/UQCRQ/UBE2L3/PSMB5/SLC25A6/PIK3R4/GPX8/HSD17B10/WNT10B/ATP5PB/ATG14/HIP1/DCTN2/NDUFA8/CALM2/GPX3/ATP5MC3	3.51189986298427
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1060	83/9376	2.13139349852239	DCAF7/UBE2D2/HCFC1/RING1/CBX4/EZH1/RBBP7/FOXK2/MBD6/L3MBTL2/CSNK2B/CBX6/HDAC2/CREBBP/HDAC1/PCGF1/YY1/BAP1/ASXL1/YAF2	3.69620531234271
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/1060	233/9376	1.63239128674387	FN1/DCN/FBLN1/MYL9/TPM1/TPM2/COL6A3/SPTBN1/FBN1/PDLIM1/ITGA1/ITGB8/INF2/NID1/SYNE2/ACTG1/COL6A2/PDLIM7/PDLIM2/COL1A1/DSP/PDLIM4/NID2/ITGB1/COL4A2/LMOD1/BGN/HSPG2/VCAN/COL5A1/FHL2/DTNA/COL4A1/SNTB2/TLN1/SUN1/ITGB7/SYNE3/LMNA/THBS3/VCL/ITGA3/ENO2	3.48980217199265
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/1060	44/9376	2.61337907375643	PRKACA/DCTN5/CREB1/DYNLL2/CREB3/DYNC1LI2/CREB3L1/RAB11A/DYNC1LI1/DYNC2LI1/DCTN2/RAB11B/PRKACB	3.82962917758912
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	31/1060	157/9376	1.74652085085927	MT-CYB/MT-CO2/MT-CO3/COX7A1/COX4I1/NDUFA5/COX6C/NDUFS4/UQCRFS1/NDUFB6/NDUFA9/NDUFV3/NDUFA10/NDUFA2/NDUFAB1/TRAF2/PRKAG1/NDUFC1/MAP3K11/AKT2/RXRA/SDHA/NDUFB4/COX7A2L/UQCRB/MAP3K5/MLXIP/BCL2L11/UQCRQ/INSR/NDUFA8	3.36768289913013
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1060	169/9376	1.67484648877973	RPS27A/UBA52/PRKACA/MTMR14/VPS41/PDPK1/BECN1/WDR45B/ATG10/ATG101/SNAP29/GABARAP/NBR1/VPS18/WDR41/TSC2/AKT2/WIPI2/MAP2K2/OPTN/RUBCN/ATG9B/IGBP1/PIK3R4/GABARAPL2/HMGB1/ATG4D/ATG14/RRAGA/YKT6/ATG4B/PRKACB	3.16060777288498
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1060	34/9376	2.6015538290788	POLR2L/POLR2J/POLR1D/CRCP/POLR2D/POLR3GL/POLR1A/POLR3D/POLR3A/POLR2F	3.33996870580748
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/1060	89/9376	1.88831884672461	FN1/COL6A3/ITGA1/ITGB8/LAMA4/COL6A2/TNXB/COL1A1/ITGB1/COL4A2/HSPG2/COL4A1/LAMB3/ITGB7/VWF/VTN/THBS3/ITGA3/LAMA3	3.00612812843156
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/1060	250/9376	1.48600754716981	HLA-E/CAV1/EGFR/EHD2/HLA-C/FOLR2/HLA-G/RAB4A/WASL/WASHC1/SNX12/SH3KBP1/RAB31/GBF1/WWP1/CBLB/ARPC5L/RNF41/VPS35/VPS37B/PIP5K1A/VPS4A/PRKCI/BIN1/VPS37C/RAB11A/VPS4B/VPS28/RUFY2/MVB12A/CAV2/WIPF2/EPN1/VPS25/CYTH2/HLA-A/ACAP1/RAB11B/CLTB/IL2RB/SH3GL1/VPS26B	2.78069986668454
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	23/1060	117/9376	1.7388163199484	SS18/ACTG1/SMARCB1/SMARCC1/CHRAC1/BCL7C/SMARCD2/RBBP7/SMARCC2/ARID1A/KAT5/TRRAP/HDAC2/BRD8/SMARCD1/PHF10/POLE3/HDAC1/YEATS4/YY1/SMARCA5/GATAD2B/INO80E	2.87097029800476
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1060	31/9376	2.56798539257456	SRP14/SEC62/SRPRB/BAG6/SRP68/SEC61A1/OXA1L/SPCS1/SEC11A	3.12186800654296
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1060	105/9376	1.76905660377358	RPS27A/UBA52/MFN2/FUNDC1/MON1B/BECN1/TFEB/CSNK2A2/HUWE1/GABARAP/TOMM70/NBR1/CSNK2B/TRAF2/MUL1/VCP/OPTN/TOMM40/ATG9B/GABARAPL2/SAMM50	2.82924785457253
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	19/1060	93/9376	1.80710083181173	HLA-DRB5/HLA-DRA/HLA-DPB1/NFKBIB/HLA-DRB1/NOTCH1/GATA3/NFATC2/HLA-DMB/NFATC3/PPP3CB/IKBKG/STAT5B/HLA-DPA1/STAT1/CD3D/CD3E/IL2RB/CD3G	2.79258515122591
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1060	63/9376	1.96561844863732	POLR2L/POLR2J/CUL4B/ERCC1/POLR2D/RPA2/CETN2/CDK7/POLE3/DDB1/UVSSA/DDB2/POLR2F/XPA	2.74544253777998
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/1060	39/9376	2.26802128688921	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/HLA-DMB/HLA-DPA1/HLA-A	2.83293427544437
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/1060	109/9376	1.70413709537822	HLA-DRB5/HLA-DRA/IL1R1/HLA-DPB1/NFKBIB/HLA-DRB1/GATA3/NFATC2/HLA-DMB/NFATC3/PPP3CB/IKBKG/STAT5B/HLA-DPA1/STAT1/RXRA/RXRB/CD3D/CD3E/IL2RB/CD3G	2.6398680656445
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	40/1060	250/9376	1.41524528301887	CD63/ACP5/SLC17A5/AP3B1/PSAP/VPS41/SLC29A3/TFEB/ACP2/AP3D1/GUSB/SNAP29/VPS35/GLB1/TTI1/VPS18/NAGLU/TELO2/SUMF1/ATP6V0E2/GGA3/LAMTOR5/AP5Z1/CTSW/OSBPL1A/CTSK/ATP6V0D1/AP3M2/NCOA7/LAMTOR1/SLC29A1/ARSA/ATP6V0B/TPCN1/FUCA2/RRAGA/CLTB/IDUA/VPS26B/ATP6V1E1	2.37583245333536
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1060	19/9376	2.79324726911619	DLST/PDHA1/LIAS/LIPT1/OGDH/GCSH	2.79337983925005
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1060	30/9376	2.35874213836478	DLST/PDHA1/SUCLG1/IDH3G/SDHA/MDH2/OGDH/IDH2	2.66113013990136
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/1060	48/9376	2.02704402515723	ACAT1/ALDH6A1/ACSF3/IVD/HADH/ECHS1/ALDH9A1/ACADS/HMGCL/HSD17B10/ACAA1	2.54681114033287
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	22/1060	122/9376	1.5950510361893	WNT4/FOXO1/PRKACA/ACTG1/NOTCH1/PDPK1/NCOA1/DIO2/MED4/HDAC2/TSC2/CREBBP/STAT1/AKT2/PFKP/RXRA/SLC2A1/MAP2K2/HDAC1/BMP4/RXRB/PRKACB	2.36184130806517
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/1060	88/9376	1.70874785591767	SERPINE2/CLU/SERPINE1/F2R/CD59/C1R/TFPI/CFD/PROCR/A2M/SERPING1/C1QB/SERPINB2/FGG/F10/VWF/VTN	2.38480745858555
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	13/1060	63/9376	1.82521713087751	DLST/PLOD1/NSD3/ACAT1/EZH1/SETD7/HADH/PLOD3/ECHS1/ALDH9A1/KMT2B/KMT5B/SETD1B	2.34625406879194
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1060	44/9376	2.01029159519726	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/HLA-DMB/HLA-DPA1/HLA-A	2.39809864512013
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1060	70/9376	1.76905660377358	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/CAV1/HLA-C/HLA-G/ACTG1/HLA-DRB1/HLA-DMB/DTNA/SNTB2/HLA-DPA1/HLA-A	2.30572300207252
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/1060	45/9376	1.96561844863732	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/HLA-DMB/HLA-DPA1/HLA-A	2.31808334827658
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/1060	46/9376	1.92288761279737	PSMA7/PSMB4/PSMB7/PSMF1/PSMD3/PSME1/PSMD2/ADRM1/PSMB5/PSMB8	2.24010430824709
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/1060	205/9376	1.38072710538426	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/RELB/NFKBIB/HLA-DRB1/CCND3/SNW1/IRF3/HLA-DMB/TRADD/IKBKG/TRAF2/PSMD3/HDAC2/FADD/HLA-DPA1/STAT1/AKT2/CDK4/HDAC1/PSMD2/DDB2/ADRM1/BCL2L11/CD3D/HLA-A/CD3E/CD3G	1.96772186414559
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/1060	138/9376	1.47421383647799	RPS6/FOXO1/PRKACA/HK1/EXOC7/PDPK1/CBLB/EIF4E2/FLOT2/INPPL1/CRKL/TSC2/PRKCI/PRKAG1/AKT2/MAP2K2/CRK/SHC1/PPP1R3D/INSR/CALM2/PRKACB/PHKG2	2.00357736317275
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1060	23/9376	2.30746513535685	PCYOX1/GGPS1/ICMT/ACAT1/FDPS/PDSS2	2.24129952046351
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1060	75/9376	1.65111949685535	GAPDH/TPI1/GOT2/PYCR2/IDH3G/PFKP/PKM/TKT/ASS1/PRPS2/SHMT2/IDH2/ENO2/ALDH18A1	2.02119325323324
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1060	42/9376	1.89541778975741	AOC1/DLST/MAOA/ACAT1/HADH/MAOB/ECHS1/ALDH9A1/KYAT3	2.07633677452247
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1060	62/9376	1.71199026171637	CTBP1/TLE3/NOTCH1/APH1A/SNW1/MFNG/DVL2/HDAC2/CREBBP/RFNG/HDAC1/APH1B	2.00808971618513
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/1060	90/9376	1.57249475890985	EGFR/NFKBIB/NFATC2/MAP3K3/NFATC3/CSNK2A2/PPP3CB/CSNK2B/IKBKG/PTPN11/STAT1/AKT2/MAP2K2/CD3D/CD3E/CD3G	1.9483176313193
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1060	49/9376	1.80515979976896	GALNT15/GALNT11/GALNT2/POGLUT1/MFNG/PLOD3/FUT11/RFNG/B3GLCT/EOGT	2.01739279447049
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/1060	142/9376	1.43268668615466	RPS27A/ELOB/UBA52/CDC16/UBE2D2/CUL4B/FBXW7/SAE1/KEAP1/WWP2/WWP1/RNF7/CBLB/PRPF19/HUWE1/UBE2M/MGRN1/DDB1/DDB2/UBE2L3/UBE2Q2/FBXW11/UBE2E3	1.85482994925566
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1060	50/9376	1.76905660377358	AOC1/MAOA/GOT2/PYCR2/MAOB/ALDH9A1/ALDH4A1/P4HA2/SMOX/ALDH18A1	1.94660095832211
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/1060	78/9376	1.58761490082245	CNOT7/MTREX/LSM2/EXOSC1/EXOSC8/TENT4B/XRN2/LSM3/PFKP/PARN/NUDT16/ENO2/CNOT6L/DIS3L	1.86048709130062
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/1060	100/9376	1.50369811320755	HLA-DRB5/CD59/HLA-DRA/IL1R1/HLA-DPB1/IL1R2/ITGA1/CSF1R/HLA-DRB1/HLA-DMB/CSF2RA/HLA-DPA1/CD3D/CD3E/ITGA3/CD3G/CD24	1.80788701115451
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	51/1060	362/9376	1.24615865735432	FN1/FLT1/PRL/PRLR/RPS6/F2R/COL6A3/EGFR/KDR/ITGA1/ITGB8/LAMA4/CSF1R/CDC37/COL6A2/PDPK1/TNXB/COL1A1/CREB1/CCND3/ITGB1/COL4A2/PPP2R5A/EIF4E2/CREB3/CSH1/IKBKG/COL4A1/VEGFB/YWHAE/GNG12/TSC2/LAMB3/CREB3L1/ITGB7/AKT2/RXRA/VWF/MAP2K2/CDK4/PPP2R5B/BCL2L11/VTN/THEM4/INSR/THBS3/YWHAQ/ITGA3/IL2RB/PPP2R1A/LAMA3	1.7052652942399
Human Diseases	Immune disease	hsa05310	Asthma	7/1060	32/9376	1.93490566037736	HLA-DRB5/PRG2/HLA-DRA/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DPA1	1.89128811749282
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1060	59/9376	1.64912056283978	GSTP1/GPX4/PGD/GSTA1/G6PD/GGCT/GCLC/LANCL1/GPX8/IDH2/GPX3	1.78564308180355
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/1060	155/9376	1.3695922093731	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/C1R/HLA-C/HLA-G/ACTG1/HLA-DRB1/ITGB1/HLA-DMB/TUBA3E/DYNC1LI2/ATP6V0E2/HLA-DPA1/DYNC1LI1/ATP6V0D1/SEC61A1/ATP6V0B/THBS3/HLA-A/MRC2/RILP/ATP6V1E1	1.65646009033168
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1060	82/9376	1.51017027151404	HLA-DRB5/CD74/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/CREB1/HLA-DMB/PSME1/HLA-DPA1/RFXANK/HLA-A	1.65654054708494
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/1060	54/9376	1.63801537386443	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/HLA-DMB/HLA-DPA1/HLA-A	1.67862932148885
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1060	15/9376	2.35874213836478	GLB1/ST6GALNAC4/ST3GAL2/ST3GAL5	1.8801949492082
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1060	77/9376	1.49335947071796	CTBP1/CRKL/IKBKG/PTPN11/HDAC2/STAT5B/AKT2/MAP2K2/CDK4/HDAC1/DDB2/CRK/SHC1	1.5519296793862
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/1060	56/9376	1.57951482479784	DDOST/FUT8/MAN1B1/MGAT4B/MAN2A1/SRD5A3/DHRSX/STT3A/DPAGT1/ALG3	1.55285869486656
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/1060	248/9376	1.24832623250152	MYL9/RPS3/GAPDH/AHNAK2/DCTN5/EXOC7/VPS41/ACTG1/CSE1L/WASL/FLNA/TRADD/DYNLL2/ARPC5L/TUBA3E/VPS18/IKBKG/TRAF2/KLC1/DYNC1LI2/FADD/AKT2/BRK1/MAP2K2/DYNC1LI1/FYCO1/NCKAP1/TNFSF10/PODXL/DYNC2LI1/CYTH2/STX10/TCF7L2/DCTN2/RILP	1.41495280638632
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1060	78/9376	1.47421383647799	FN1/CAV1/ACTG1/WASL/ITGB1/ARPC5L/CRKL/GAB1/CRK/SHC1/CAV2/VCL/CLTB	1.5014403481746
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1060	16/9376	2.21132075471698	MIF/MAOA/GOT2/MAOB	1.73126104031646
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1060	108/9376	1.39231306778477	EEF1A1/IPO8/XPO6/CSE1L/POM121/CASC3/GLE1/SNUPN/IPO5/XPO7/RAE1/PHAX/KPNB1/UPF1/RANGAP1/IPO13/UPF3A	1.46397267337978
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1060	93/9376	1.42665855143031	MYL9/EGFR/ACTG1/WASL/TJP1/CSNK2A2/CCM2/WAS/CSNK2B/NECTIN2/CREBBP/KRIT1/INSR/VCL/TCF7L2	1.47624719044495
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/1060	93/9376	1.42665855143031	FN1/LAMA4/ITGB1/COL4A2/IKBKG/TRAF2/COL4A1/LAMB3/AKT2/RXRA/CDK4/RXRB/DDB2/ITGA3/LAMA3	1.47624719044495
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1060	57/9376	1.55180403839788	HACD2/CPT2/ACAT1/FADS1/ACSF3/HADH/ECHS1/ACADS/ACAA1/ELOVL1	1.49182876566178
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1060	109/9376	1.37953955340142	FOXO1/GFPT1/PDPK1/CREB1/NR1H2/CREB3/PTPN11/CREB3L1/PRKAG1/AKT2/SLC2A1/MLXIP/OGA/SLC27A1/PPP1R3D/INSR/PTPA	1.4229250997424
Genetic Information Processing	Transcription	hsa03040	Spliceosome	34/1060	243/9376	1.23761161580868	SNRNP27/CRNKL1/RBMX2/DHX8/CDC5L/CTNNBL1/SNRPE/LSM2/DDX42/SF3B4/SNRNP70/SF3B3/SF3A1/SNIP1/DHX38/SNW1/CASC3/SNRPD1/PRPF19/SLU7/U2SURP/LSM3/SNRPB/SNRPA/RBMX/GPKOW/SART1/PPIE/SNRPC/XAB2/DDX46/SNRPG/ISY1/RP9	1.33981675981155
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/1060	110/9376	1.36699828473413	FLT1/TIMP1/RPS6/SERPINE1/ELOB/GAPDH/EGFR/HK1/PDHA1/EIF4E2/CREBBP/AKT2/PFKP/SLC2A1/MAP2K2/INSR/ENO2	1.38227852090535
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/1060	180/9376	1.27765199161426	HLA-DRB5/CD74/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/HLA-G/HLA-DRB1/EIF2B5/HCFC1/EIF2B3/IRF3/HLA-DMB/TRADD/POU2F1/IKBKG/TRAF2/NECTIN2/PTPN11/FADD/TSC2/HLA-DPA1/STAT1/AKT2/HCFC2/HLA-A	1.34282338191528
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	29/1060	204/9376	1.25741768405475	TIMP3/LUM/FN1/DCN/RPS6/CD63/CAV1/EGFR/KDR/WNT4/MMP2/PRKACA/ACTG1/PDPK1/COL1A1/WNT5A/ITGB1/FLNA/HSPG2/PTPN11/AKT2/MAP2K2/TIAM1/GAB1/VTN/PPP1R12C/CAV2/WNT10B/PRKACB	1.32709731315201
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	23/1060	157/9376	1.29580579257301	MFGE8/BSG/VPS41/UQCRFS1/C1QB/RAB14/CREB1/NR1H2/DUSP16/NFATC2/NFATC3/CRKL/VPS18/PTPN11/RXRA/SLC2A1/GAS6/MAP2K2/ATP8A2/CRK/ATP11C/CD24/NFATC4	1.33443038860216
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1060	51/9376	1.56093229744728	PRKACA/ACTG1/TJP1/ATP6V0E2/ATP6V0D1/SEC61A1/ATP6V0B/PRKACB/ATP6V1E1	1.43401087515005
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	35/1060	253/9376	1.22365575359833	MYL9/RPS27A/UBA52/IL1R1/EGFR/FOXO1/UBE2V1/HK1/UBE2D2/NFKBIB/ACTG1/WASL/RBCK1/CAPN1/BECN1/UBE2V2/ITGB1/IRF3/TRADD/ARPC5L/CRKL/IKBKG/TRAF2/TLN1/AKT2/WIPI2/SHARPIN/CRK/CAPNS1/PIK3R4/CYTH2/VCL/ATG14/RRAGA/FBXW11	1.2875165748513
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/1060	205/9376	1.25128393925449	HLA-E/HLA-C/PRKACA/HLA-G/VDAC3/CREB1/CCND3/SNW1/IRF3/TRADD/CREB3/IKBKG/TRAF2/HDAC6/HDAC2/YWHAE/STAT5B/CREB3L1/CREBBP/GTF2E2/PKM/ATP6V0D1/CDK4/DDB1/HDAC1/SRF/HLA-A/YWHAQ/PRKACB	1.29871736051112
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	21/1060	144/9376	1.28993710691824	PSMA7/VDAC3/BECN1/ATG101/PSMB4/PSMB7/AFG3L2/KAT5/TRAF2/PSMD3/AKT2/WIPI2/MAP3K5/PSMD2/ADRM1/PSMB5/SLC25A6/NOP56/CIC/PIK3R4/ATG14	1.25175253536201
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/1060	137/9376	1.29128219253546	ACTG1/PDPK1/CAPN1/TRADD/TUBA3E/IKBKG/TRAF2/FADD/CTSW/AKT2/CTSK/MAP2K2/MAP3K5/BCL2L11/TNFSF10/PARP1/LMNA/PARP3/NOL3/PTPN13	1.22614848390261
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/1060	106/9376	1.33513705945176	GSTP1/IL1R2/EGFR/ZEB1/FOXO1/FOLR2/PDPK1/CREB1/SPINT1/CREB3/IKBKG/CREB3L1/CREBBP/AKT2/MAP2K2/TCF7L2	1.23884465335743
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/1060	122/9376	1.30504175688215	NFKBIB/PDPK1/NFATC2/PPP2R5A/CBLB/NFATC3/PPP3CB/IKBKG/PTPN11/PAK4/AKT2/MAP2K2/CDK4/PPP2R5B/CD3D/CD3E/CD3G/PPP2R1A	1.2107536635897
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1060	107/9376	1.32265914300829	FOXO1/PRKACA/CREB1/PDHA1/PPP3CB/CREB3/CREB3L1/PRKAG1/CREBBP/AKT2/PFKP/SLC2A1/PKM/CALM2/PRKACB/PHKG2	1.19839711332996
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1060	69/9376	1.41011758271807	PRKACA/MAOA/CREB1/PPP3CB/CREB3/HDAC2/MAOB/CREB3L1/HDAC1/CALM2/PRKACB	1.22070130213783
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1060	47/9376	1.50558008831794	GLO1/PDHA1/ACAT1/ALDH9A1/PKM/MDH2/ME3/HAGH	1.24051686905482
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/1060	85/9376	1.35280799112098	GUK1/NME1/HDDC2/CANT1/AK3/AK2/NME6/ENTPD6/ADK/GMPS/NUDT16/GMPR2/UCK1	1.16653554542056
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1060	19/9376	1.86216484607746	GUSB/GLB1/NAGLU/IDUA	1.34301272368861
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1060	33/9376	1.6082332761578	DLST/GOT2/PDHA1/IDH3G/OGDH/IDH2	1.24958355912908
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1060	33/9376	1.6082332761578	STX8/STX16/SNAP29/VAMP5/BET1L/YKT6	1.24958355912908
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/1060	173/9376	1.22709128585451	HLA-DRB5/HLA-DRA/HLA-DPB1/NFKBIB/ACTG1/HLA-DRB1/CCND3/IRF3/HLA-DMB/TRADD/IKBKG/FADD/RAE1/HLA-DPA1/CREBBP/STAT1/AKT2/RAB11A/MAP2K2/CDK4/FDPS/TNFSF10/SLC25A6/RAB11B	1.07631685285403
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/1060	157/9376	1.23946641028723	IGFBP3/SERPINE1/HLA-E/FOXO1/HLA-C/HLA-G/VDAC3/CAPN1/CCND3/NFATC2/NFATC3/PPP3CB/TSC2/AKT2/MAP2K2/CDK4/HIPK2/SLC25A6/HLA-A/FBXW11/CALM2/NFATC4	1.08027382478617
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	29/1060	214/9376	1.19865984835126	HLA-E/ELOB/HLA-C/HLA-G/APOBEC3C/CUL4B/NFATC2/IRF3/RNF7/TRADD/NFATC3/PPP3CB/CRKL/IKBKG/TRAF2/GNG12/FADD/PAK4/AKT2/MAP2K2/DDB1/CRK/CD3D/HLA-A/CD3E/FBXW11/CALM2/CD3G/NFATC4	1.04955009691514
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/1060	95/9376	1.30351539225422	HLA-DRB5/FLT1/HLA-DRA/HLA-DPB1/ACP5/HLA-DRB1/HLA-DMB/ATP6V0E2/HLA-DPA1/CTSK/ATP6V0D1/LTB/ATP6V0B/ATP6V1E1	1.06151581103883
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1060	27/9376	1.63801537386443	ACAT1/HADH/ECHS1/ACADS/HMGCL	1.185254946507
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1060	20/9376	1.76905660377358	CYB5R1/CMAS/GMPPB/UAP1	1.22916313799598
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/1060	136/9376	1.23573806881243	RACK1/NFKBIB/CCND3/IRF3/TRADD/CBLB/CSNK2A2/CSNK2B/IKBKG/EIF3H/STAT5B/FADD/STAT1/AKT2/CDK4/CD3D/CD3E/IL2RB/CD3G	0.988654438661225
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1060	65/9376	1.36081277213353	KCNK3/CYP11A1/PRKACA/ORAI1/CREB1/CREB3/CREB3L1/HSD3B1/STAR/PRKACB	1.04212963934373
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1060	28/9376	1.57951482479784	HACD2/HADH/ECHS1/THEM4/ELOVL1	1.09639120889762
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1060	178/9376	1.19262242951028	NOTUM/DKK1/WNT4/PRKACA/CTBP1/TLE3/APCDD1/WNT5A/CCND3/NFATC2/NFATC3/CSNK2A2/PPP3CB/CSNK2B/SFRP1/DVL2/CREBBP/LGR4/NKD2/WNT10B/TCF7L2/FBXW11/PRKACB/NFATC4	0.926299618681936
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1060	43/9376	1.4399297937692	CPT2/ACAT1/HADH/ECHS1/ALDH9A1/ACADS/ACAA1	1.03225810252021
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1060	43/9376	1.4399297937692	APOA1/AGPAT2/PLPP1/GOT2/ACAT1/AGPAT1/SLC27A1	1.03225810252021
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1060	21/9376	1.6848158131177	CHPF/B3GALT6/B3GAT3/CHPF2	1.12161255510034
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/1060	170/9376	1.19671476137625	GSTP1/EGFR/WNT4/ACTG1/SMARCB1/SMARCC1/WNT5A/KEAP1/SMARCD2/GSTA1/SMARCC2/ARID1A/DVL2/SMARCD1/PHF10/AKT2/MAP2K2/CDK4/DDB2/GAB1/SHC1/WNT10B/TCF7L2	0.924075075169988
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/1060	196/9376	1.17335386984983	RPS27A/HLA-E/UBA52/HLA-C/HLA-G/BECN1/CREB1/NFATC2/IRF3/TRADD/NFATC3/PPP3CB/IKBKG/TRAF2/GNG12/FADD/CREBBP/STAT1/AKT2/MAP2K2/CDK4/HLA-A/ATG14/TCF7L2/CALM2/NFATC4	0.875631883308306
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1060	44/9376	1.40720411663808	DDOST/FUT8/MAN1B1/MGAT4B/MAN2A1/STT3A/ALG3	0.966568112651135
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1060	44/9376	1.40720411663808	TAF15/GTF2F1/TAF10/TAF3/TAF2/CDK7/GTF2E2	0.966568112651135
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1060	44/9376	1.40720411663808	TDG/SMUG1/POLE3/APEX1/PARP1/PARP3/HMGB1	0.966568112651135
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1060	29/9376	1.52504879635654	RASSF2/LATS2/TEAD1/RASSF1/WWTR1	1.01098305232279
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1060	22/9376	1.6082332761578	AOC1/MAOA/MAOB/ALDH9A1	1.01968061866596
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1060	37/9376	1.43437021927588	CCDC6/RXRA/MAP2K2/RXRB/DDB2/TCF7L2	0.945131084400832
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1060	15/9376	1.76905660377358	AK2/NFS1/THTPA	1.06420217732447
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	23/1060	174/9376	1.16920407720668	CRYAB/SSR4/SEC62/BCAP29/UBE2D2/DDOST/CAPN1/MAN1B1/DNAJB12/SSR1/RNF185/TRAF2/ATF6/UBXN2A/BAG1/SEC31A/VCP/UBQLN4/STT3A/MAP3K5/DNAJC5/UBXN4/SEC61A1	0.804314066261031
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/1060	158/9376	1.1756388822546	CDKN1C/CDC16/CCND3/SMC1A/PPP2R5A/ORC3/PDS5B/CDK7/HDAC2/YWHAE/MCM5/CREBBP/SMC3/CDK4/HDAC1/PPP2R5B/MAU2/TFDP2/YWHAQ/CDKN2D/PPP2R1A	0.794899432129816
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1060	86/9376	1.23422553751645	GJA1/ITGA1/ITGB8/ACTG1/DSP/ITGB1/DTNA/SNTB2/ITGB7/LMNA/TCF7L2/ITGA3	0.779034952599604
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/1060	62/9376	1.28399269628728	CRYAB/FOXO1/PRKACA/HDAC2/PRKAG1/AKT2/HDAC1/INSR/PRKACB	0.800969962020841
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1060	70/9376	1.26361185983827	NFKBIB/TRADD/IKBKG/TRAF2/PTPN11/PRKAG1/AKT2/RXRA/SLC2A1/RXRB	0.790339652329639
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/1060	70/9376	1.26361185983827	ELOB/CRKL/PTPN11/PAK4/CREBBP/AKT2/SLC2A1/MAP2K2/GAB1/CRK	0.790339652329639
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1060	31/9376	1.42665855143031	PGD/G6PD/PFKP/TKT/PRPS2	0.849479649323271
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1060	31/9376	1.42665855143031	ALDH6A1/ECHS1/ALDH9A1/ACADS/SMOX	0.849479649323271
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/1060	103/9376	1.20227147829273	SSU72/CPSF2/GSPT1/CASC3/GLE1/PPP2R5A/CSTF3/WDR82/FIP1L1/UPF1/PPP2R5B/HBS1L/UPF3A/PPP2R1A	0.736926987596358
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/1060	87/9376	1.22003903708523	MT-CYB/MT-CO2/MT-CO3/COX7A1/TPM1/TPM2/COX4I1/COX6C/UQCRFS1/COX7A2L/UQCRB/UQCRQ	0.736132871250206
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1060	71/9376	1.24581450969971	EGFR/TJP1/IKBKG/PTPN11/ATP6V0E2/ATP6V0D1/JAM2/ATP6V0B/CSK/ATP6V1E1	0.742266448979017
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1060	71/9376	1.24581450969971	EGFR/HK1/PDHA1/G6PD/AKT2/PFKP/SLC2A1/MAP2K2/PKM/IDH2	0.742266448979017
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/1060	112/9376	1.18463611859838	HLA-DRB5/HLA-DRA/HLA-DPB1/LAMA4/NFKBIB/HLA-DRB1/PDPK1/ITGB1/HLA-DMB/IKBKG/LAMB3/HLA-DPA1/STAT1/AKT2/LAMA3	0.701790896813569
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1060	32/9376	1.38207547169811	HK1/GALM/GLB1/PFKP/GANC	0.772928039944087
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1060	48/9376	1.28993710691824	CD81/CD63/EGFR/CLDN5/HSPG2/VPS4A/VPS4B	0.718971179236653
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/1060	105/9376	1.17937106918239	RELB/BCL3/NFATC2/CBLB/NFATC3/PPP3CB/IKBKG/PTPN11/LSP1/STAT1/AKT2/KSR1/CALM2/NFATC4	0.659880183287607
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	16/1060	122/9376	1.16003711722858	EEF2/FOXO1/PDPK1/RAB14/CREB1/PPP2R5A/CREB3/TSC2/CREB3L1/PRKAG1/AKT2/PFKP/PPP2R5B/INSR/RAB11B/PPP2R1A	0.635209841351968
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/1060	73/9376	1.21168260532437	MAP1B/APOBEC3C/SMARCB1/MAP1A/FURIN/VPS4A/NELFB/CREBBP/SUPT4H1/VPS4B	0.648211038032872
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1060	73/9376	1.21168260532437	EGFR/PDPK1/STAT5B/AKT2/RXRA/MAP2K2/CDK4/RXRB/DDB2/RASSF1	0.648211038032872
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1060	49/9376	1.26361185983827	PRKACA/MAOA/CREB1/CREB3/MAOB/CREB3L1/PRKACB	0.660500768576996
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/1060	90/9376	1.17937106918239	FOXO1/PRKACA/CREB1/ATG101/EIF4E2/CREB3/TSC2/CREB3L1/PRKAG1/AKT2/INSR/PRKACB	0.610436709153651
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/1060	157/9376	1.12678764571566	SERPINE1/WNT4/ACTG1/WNT5A/CCND3/BMP8B/DVL2/YWHAE/PRKCI/BMP4/LATS2/TEAD1/RASSF1/WWTR1/NKD2/WNT10B/TCF7L2/YWHAQ/FBXW11/PPP2R1A	0.571960697154173
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/1060	149/9376	1.12792199569457	MT-ND3/NDUFA5/PRKACA/NDUFS4/MT-ND4/NDUFB6/NDUFA9/NDUFV3/NDUFA10/NDUFA2/MT-ND1/NDUFAB1/GNG12/NDUFC1/CNR1/NDUFB4/NDUFA8/ABHD6/PRKACB	0.561939331604763
NA	NA	hsa04382	Cornified envelope formation	27/1060	217/9376	1.10056516824624	S100A6/KRT18/KRT8/KRT7/KRT19/S100A4/COL17A1/SPTLC2/S100A13/CLDN5/CAPN1/DSP/KDSR/TJP1/COL4A2/PPP2R5A/FURIN/S100A16/COL4A1/LAMB3/PRSS8/PPP2R5B/SLC27A1/TCHH/PPP2R1A/LAMA3/ELOVL1	0.535099755378321
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1060	91/9376	1.16641094754302	CD81/INPP5D/NFKBIB/NFATC2/NFATC3/PPP3CB/INPPL1/IKBKG/AKT2/MAP2K2/CD72/LILRA6	0.569499000361615
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1060	133/9376	1.13060008511846	EGFR/FOXO1/DEPP1/PDPK1/SETD7/GABARAP/CCNG2/PRKAG1/CREBBP/AKT2/MAP2K2/BCL2L11/TNFSF10/FBXO25/INSR/GABARAPL2/CDKN2D	0.541556950985919
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1060	18/9376	1.47421383647799	GLB1/MAN2B2/FUCA2	0.718952642304618
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1060	50/9376	1.23833962264151	HLA-DRB5/HLA-DRA/HLA-DPB1/HLA-DRB1/HLA-DMB/HLA-DPA1/ITGB7	0.603274369615431
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1060	83/9376	1.17226642418732	POLR2L/NFKBIB/POLR1D/IRF3/POLR3GL/IKBKG/DDX41/FADD/POLR3D/POLR3A/POLR2F	0.562785691318727
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1060	34/9376	1.3007769145394	RORB/CREB1/PRKAG1/FBXW11/NR1D1	0.627256770113533
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/1060	75/9376	1.17937106918239	IGFBP3/SERPINE1/CD82/CCND3/CCNG2/AIFM2/TSC2/CDK4/DDB2/PERP	0.556800397788153
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/1060	227/9376	1.09104812567534	HLA-E/IL1R1/EGFR/HLA-C/PRKACA/HLA-G/CREB1/NFATC2/IRF3/TRADD/NFATC3/PPP3CB/CRKL/CREB3/IKBKG/TRAF2/GNG12/FADD/TSC2/CREB3L1/AKT2/MAP2K2/CDK4/CRK/HLA-A/CALM2/PRKACB/NFATC4	0.495767958761284
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/1060	67/9376	1.18817234581808	GAPDH/TPI1/HK1/GALM/PDHA1/ALDH9A1/PFKP/PKM/ENO2	0.551852501742296
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1060	101/9376	1.13850177470577	WNT4/PRKACA/CREB1/WNT5A/CREB3/DVL2/CREB3L1/CREBBP/MAP2K2/WNT10B/TCF7L2/CALM2/PRKACB	0.499620668989543
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1060	35/9376	1.26361185983827	TPI1/HK1/HSD17B14/PFKP/GMPPB	0.557806552801675
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1060	27/9376	1.31041229909154	HACD2/FADS1/ACAA1/ELOVL1	0.576659635529476
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/1060	170/9376	1.0926526082131	MYL9/MYL6/PRKACA/ACTG1/CLDN5/TJP1/ITGB1/ARPC5L/TUBA3E/WAS/PRKCI/PRKAG1/TIAM1/MAP3K5/CDK4/JAM2/PRKACB/MYL6B/PPP2R1A/RAB13/SYNPO	0.435239151857315
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	16/1060	128/9376	1.10566037735849	ATIC/GUK1/NME1/HDDC2/CANT1/AK3/AK2/NME6/ENTPD6/ADK/GMPS/NUDT2/PRPS2/NUDT16/GMPR2/PDE4A	0.429709111187823
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1060	103/9376	1.11639494412896	FN1/HSPB1/IL1R1/IL1R2/PRKACA/LAMA4/COL1A1/COL4A2/COL4A1/LAMB3/VCL/PRKACB/LAMA3	0.424056699799607
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1060	36/9376	1.22851153039832	GALNT15/GALNT11/GALNT2/ST6GALNAC4/ST3GAL2	0.490418970902921
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1060	36/9376	1.22851153039832	RPA2/MCM5/SSBP1/POLE3/RNASEH1	0.490418970902921
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1060	78/9376	1.13401064344461	HLA-DRB5/HLA-DRA/HLA-DPB1/EEF1A1/NFKBIB/HLA-DRB1/ITGB1/HLA-DMB/HLA-DPA1/STAT1	0.424300118796536
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1060	155/9376	1.08426049908704	EGFR/WNT4/KCNK3/CYP11A1/PRKACA/ORAI1/CREB1/WNT5A/CREB3/DVL2/CREB3L1/HSD3B1/MAP2K2/CDK4/ARMC5/STAR/WNT10B/TCF7L2/PRKACB	0.377643658035568
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/1060	138/9376	1.08963631391851	FN1/ACTG1/WASL/NFATC2/ITGB1/IRF3/NFATC3/ARPC5L/CRKL/WAS/IKBKG/TRAF2/PIP5K1A/AKT2/MAP2K2/CRK/WIPF2	0.378717944670758
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/1060	130/9376	1.08865021770682	EGFR/MMP2/PRKACA/RXFP1/COL1A1/CREB1/COL4A2/CREB3/COL4A1/VEGFB/GNG12/CREB3L1/AKT2/MAP2K2/SHC1/PRKACB	0.363375689278329
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/1060	122/9376	1.08753479740179	IGFBP3/PRKACA/CREB1/CRKL/CREB3/CSH1/STAT5B/CREB3L1/CREBBP/STAT1/AKT2/MAP2K2/CRK/SHC1/PRKACB	0.347437930233102
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1060	105/9376	1.09513027852651	TPM1/TPM2/ITGA1/ITGB8/PRKACA/ACTG1/ITGB1/DTNA/SNTB2/ITGB7/LMNA/ITGA3/PRKACB	0.349970515961189
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1060	37/9376	1.19530851606323	HK1/GFPT1/CMAS/GMPPB/UAP1	0.424965021513875
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/1060	80/9376	1.10566037735849	RPS6/EGFR/KDR/EIF4E2/AKT2/GAS6/MAP2K2/BCL2L11/GAB1/SHC1	0.338836684765768
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/1060	158/9376	1.06367327442083	RPS6/WNT4/PDPK1/WNT5A/EIF4E2/TTI1/TELO2/DVL2/TSC2/LAMTOR5/AKT2/MAP2K2/WDR59/LPIN1/LAMTOR1/INSR/WNT10B/RRAGA/ATP6V1E1	0.288169960029656
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1060	98/9376	1.08309587986138	ATP2B4/KCNK3/CYP11A1/PRKACA/ORAI1/CREB1/CREB3/CREB3L1/HSD3B1/STAR/CALM2/PRKACB	0.295220611164316
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1060	55/9376	1.12576329331046	SPTLC2/PSAP/PLPP1/KDSR/GLB1/SMPD4/ARSA	0.333952979682359
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1060	38/9376	1.16385302879841	HK1/GFPT1/AMDHD2/GMPPB/UAP1	0.361327210018751
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1060	38/9376	1.16385302879841	SIRT2/NMNAT1/QPRT/NMRK1/NNMT	0.361327210018751
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1060	38/9376	1.16385302879841	ORAI1/IKBKG/RFXANK/CD3D/CD3E	0.361327210018751
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1060	30/9376	1.17937106918239	FOLR2/ATIC/IKBKG/SHMT2	0.351302682790163
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/1060	99/9376	1.07215551743854	HLA-DRB5/KRT18/KRT19/HLA-DRA/HLA-DPB1/C1R/CFD/HLA-DRB1/C1QB/HLA-DMB/FGG/HLA-DPA1	0.25767049687803
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1060	99/9376	1.07215551743854	TPM1/TPM2/ITGA1/ITGB8/ACTG1/ITGB1/DTNA/SNTB2/PRKAG1/ITGB7/LMNA/ITGA3	0.25767049687803
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/1060	160/9376	1.05037735849057	HLA-DRB5/HLA-DRA/HLA-E/HLA-DPB1/HLA-C/ITGB8/HLA-G/HLA-DRB1/CLDN5/ITGB1/HLA-DMB/VCAN/NECTIN2/HLA-DPA1/ITGB7/ALCAM/JAM2/JAML/HLA-A	0.229459202881131
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1060	65/9376	1.08865021770682	AGPAT2/PLPP1/DGKZ/GPAT4/ALDH9A1/AGPAT1/LPIN1/AGPAT5	0.256046976553158
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1060	31/9376	1.14132684114425	ACAT1/MDH2/SHMT2/GCSH	0.28138256001835
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/1060	101/9376	1.05092471511302	FN1/SERPINE1/MMP2/FOXO1/COL1A1/COL4A2/COL4A1/VEGFB/STAT5B/STAT1/AKT2/CDK4	0.183701907696991
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1060	66/9376	1.07215551743854	HLA-DRB5/HLA-DRA/HLA-DPB1/HLA-DRB1/GATA3/HLA-DMB/HLA-DPA1/STAT1	0.21001388223882
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/1060	154/9376	1.03386424895859	NME1/AK3/DHRS3/AK2/NME6/GUSB/ALAD/PPCS/FLAD1/GCLC/NMNAT1/LIAS/QPRT/NFS1/GMPPB/LIPT1/SHMT2/COQ6	0.151276190797377
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/1060	75/9376	1.06143396226415	GSTP1/PDPK1/ERCC1/GSTA1/FADD/AKT2/MAP3K5/REV3L/XPA	0.190702183926882
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	19/1060	163/9376	1.03104525986804	VDAC3/CREB1/NFATC2/IRF3/NFATC3/CREB3/HSPG2/IKBKG/STAT5B/FADD/CREB3L1/CREBBP/STAT1/AKT2/MAP2K2/DDB1/DDB2/YWHAQ/NFATC4	0.142747955444511
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1060	14/9376	1.26361185983827	FUT8/ST3GAL2	0.352391946946599
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1060	181/9376	1.0262483060565	HLA-DRB5/CD74/HLA-DRA/HLA-DPB1/HLA-DRB1/CREB1/HLA-DMB/TRADD/PPP3CB/LSP1/FADD/HLA-DPA1/RFXANK/CREBBP/STAT1/AKT2/KSR1/ATP6V0D1/ATP6V0B/MRC2/CALM2	0.127305167442059
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/1060	120/9376	1.03194968553459	NFKBIB/PDPK1/MAP3K3/PRDM4/CRKL/PTPN11/YWHAE/AKT2/MAP2K2/MAP3K5/GAB1/CRK/SHC1/CALM2	0.125755465315636
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1060	32/9376	1.10566037735849	SUCLG1/ALDH6A1/ECHS1/ACADS	0.213748001169723
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1060	41/9376	1.07869305108145	EGFR/MMP2/MAP2K2/CDK4/RASSF1	0.180282047497301
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	21/1060	183/9376	1.01503247757501	TCOF1/EMG1/GNL2/CSNK2A2/POP4/HEATR1/CSNK2B/XRN2/POP5/UTP14C/GAR1/WDR43/WDR3/EIF6/UTP4/FCF1/NOP56/DKC1/RRP7A/POP7/IMP3	0.0733176961871717
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1060	59/9376	1.04944035817077	NME1/HDDC2/CANT1/NME6/ENTPD6/NUDT2/UCK1	0.136003754284575
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1060	201/9376	1.01214681310429	IGFBP3/FLT1/HPGD/IL1R2/ZEB1/FOXO1/SS18/TAF15/CSF1R/FUT8/FLI1/WT1/SPINT1/KLF3/HDAC2/ITGB7/RXRA/HDAC1/RXRB/DDB2/NUPR1/IL2RB/SUPT3H	0.062149647830048
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1060	139/9376	1.01816207411429	KRT18/KRT19/EGFR/MMP2/PRKACA/NCOA1/CREB1/GREB1/EBAG9/CREB3/CREB3L1/AKT2/MAP2K2/SHC1/CALM2/PRKACB	0.0770173732283352
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/1060	86/9376	1.02852128126371	EGFR/CBLB/CRKL/STAT5B/PAK4/AKT2/MAP2K2/GAB1/CRK/SHC1	0.0948618807024622
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/1060	60/9376	1.03194968553459	HSPB1/KDR/MAPKAPK3/NFATC2/PPP3CB/AKT2/MAP2K2	0.088635725478573
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1060	52/9376	1.02060957910015	CYP11A1/PRKACA/HSD3B1/STAR/INSR/PRKACB	0.053204821730471
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1060	142/9376	0.996651607759766	IL1R1/ACP5/TYROBP/TNFRSF11B/RELB/CSF1R/CREB1/NFATC2/PPP3CB/FHL2/IKBKG/TRAF2/STAT1/AKT2/CTSK/LILRA6	-0.014353800123217
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/1060	142/9376	0.996651607759766	IL1R1/GSTP1/CAV1/IL1R2/KDR/MMP2/ACTG1/KEAP1/GSTA1/IKBKG/AKT2/MAP3K5/BMP4/ASS1/CAV2/CALM2	-0.014353800123217
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1060	16/9376	1.10566037735849	GBGT1/ST3GAL2	0.151013424077448
Organismal Systems	Immune system	hsa04611	Platelet activation	14/1060	126/9376	0.982809224318658	F2R/RASGRP2/PRKACA/ACTG1/ORAI1/COL1A1/ITGB1/FGG/TLN1/PRKCI/AKT2/VWF/TBXAS1/PRKACB	-0.0693571453813166
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/1060	99/9376	0.982809224318658	EGFR/PDPK1/PLPP1/SLC44A2/DGKZ/WAS/PIP5K1A/PCYT1A/TSC2/AKT2/MAP2K2	-0.0613890090290502
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/1060	63/9376	0.982809224318658	WNT4/WNT5A/DVL2/BMP4/DDB2/WNT10B/TCF7L2	-0.048876745136335
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/1060	154/9376	0.976427346238667	MYL9/MYL6/EEF2/EGFR/PRKACA/ACTG1/NFATC2/NFATC3/PPP3CB/PRKAG1/MAP2K2/PPP1R12C/CALM2/PRKACB/MYL6B/NFATC4/OXT	-0.105302239903818
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1060	54/9376	0.982809224318658	GOT2/DNMT1/GCLC/MDH2/ADI1/KYAT3	-0.0452292237772461
NA	NA	hsa04517	IgSF CAM signaling	33/1060	299/9376	0.976235249574052	MYL9/MYL6/SPTBN1/KDR/FOXO1/CLMP/INPP5D/ACTG1/WASL/PDPK1/EPB41L1/TJP1/ITGB1/DYNLL2/ARPC5L/TUBA3E/FGG/RASA1/NECTIN2/PTPN11/PRKCI/PAK4/AKT2/CASK/MAP2K2/EPB41L2/KCNQ3/JAM2/JAML/CSK/VCL/MYL6B/PPFIA1	-0.149100470770147
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1060	17/9376	1.04062153163152	SEPHS1/KYAT3	0.0598476858373611
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/1060	200/9376	0.972981132075472	RPS3/F2R/IL1R1/GAPDH/NFKBIB/ACTG1/WASL/CLDN5/TJP1/ITGB1/TRADD/ARPC5L/TUBA3E/IKBKG/TRAF2/PTPN11/FADD/BRK1/NCKAP1/TNFSF10/WIPF2/CYTH2	-0.13789127086458
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/1060	300/9376	0.972981132075472	FLT1/HSPB1/IL1R1/RASGRP2/EGFR/KDR/PRKACA/RELB/CSF1R/MAPKAPK3/MAP4K4/DUSP16/MAP3K3/FLNA/TRADD/NFATC3/PPP3CB/CRKL/MAP3K4/IKBKG/TRAF2/RASA1/VEGFB/GNG12/MAP3K11/AKT2/MAP2K2/MAP3K5/CRK/INSR/SRF/TAOK2/PRKACB	-0.16980945285131
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/1060	83/9376	0.959127074335076	PRDX5/MPV17/ABCD1/PEX19/PEX6/HMGCL/ACAA1/ECH1/IDH2	-0.133529780019935
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/1060	184/9376	0.961443806398687	MYL9/SEMA3B/WNT4/PDPK1/WNT5A/NFATC2/ITGB1/NFATC3/PPP3CB/SEMA5A/RASA1/ABLIM1/PTPN11/DPYSL2/PAK4/EPHB2/EFNB1/RHOD/SEMA3A/NFATC4	-0.188572946239885
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/1060	166/9376	0.959127074335076	MYL9/ATP2B4/ADRA2C/VDAC3/CREB1/NFATC2/NFATC3/PPP3CB/CREB3/MEF2D/CREB3L1/AKT2/MAP2K2/INSR/SLC25A6/SRF/CALM2/NFATC4	-0.189688623418844
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1060	37/9376	0.956246812850586	GFPT1/GOT2/ALDH4A1/ASS1	-0.0952010413730822
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1060	37/9376	0.956246812850586	MIF/MAOA/GOT2/MAOB	-0.0952010413730822
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1060	37/9376	0.956246812850586	HBB/APOA1/LAMA4/HBA2	-0.0952010413730822
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1060	56/9376	0.947708894878706	PRKACA/CSNK1G2/MGRN1/MOSMO/FBXW11/PRKACB	-0.140118412467029
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1060	18/9376	0.982809224318658	HCFC1/TCN2	-0.0260628278819535
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/1060	149/9376	0.949829049005952	F2R/EGFR/AGPAT2/PLPP1/DGKZ/PIP5K1A/PTPN11/TSC2/AGPAT1/AKT2/MAP2K2/GAB1/SHC1/AGPAT5/INSR/CYTH2	-0.220392361098601
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1060	28/9376	0.947708894878706	ATP6V0E2/ATP6V0D1/ATP6V1E1	-0.0989301835005292
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/1060	232/9376	0.953155497722837	FN1/MYL9/F2R/RGCC/EGFR/ITGA1/ITGB8/ACTG1/WASL/ITGB1/ARPC5L/CRKL/PIP5K1A/GNG12/PAK4/ITGB7/AKT2/BRK1/MAP2K2/TIAM1/CRK/NCKAP1/PPP1R12C/VCL/ITGA3	-0.257938305933694
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1060	76/9376	0.931082423038729	APOA1/PDPK1/CPT2/RXRA/RXRB/SLC27A1/ACAA1/ME3	-0.215365757161419
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/1060	133/9376	0.931082423038729	PRKACA/MAOA/CREB1/PPP2R5A/PPP3CB/CREB3/GNG12/MAOB/CREB3L1/AKT2/PPP2R5B/CALM2/PRKACB/PPP2R1A	-0.28577923831084
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/1060	115/9376	0.92298605414274	EGFR/PRKACA/CREB1/GATA3/NACA/CREB3/MEF2D/CREB3L1/RXRA/RXRB/PDE4A/PRKACB	-0.296667986392904
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1060	78/9376	0.907208514755685	TPI1/MTMR14/INPP5D/INPP1/ALDH6A1/INPPL1/PIP5K1A/ITPK1	-0.293793367455508
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/1060	59/9376	0.899520307003518	EGFR/PDPK1/AKT2/MAP2K2/DDB2/TCF7L2	-0.27640607759517
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1060	30/9376	0.884528301886792	PIGP/PIGS/PGAP2	-0.226154181487637
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/1060	98/9376	0.902579899884482	INPP5D/PLPP1/ARPC5L/INPPL1/CRKL/WAS/PIP5K1A/BIN1/AKT2/CRK	-0.346111281856219
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/1060	238/9376	0.929126367528143	FLT1/RASGRP2/EGFR/KDR/PRKACA/CSF1R/RGL2/IKBKG/RASA1/RASAL3/PTPN11/VEGFB/GNG12/PAK4/AKT2/MAP2K2/KSR1/TIAM1/RASSF1/GAB1/SHC1/SYNGAP1/INSR/CALM2/PRKACB	-0.395392952632351
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1060	99/9376	0.89346293119878	EGFR/MMP2/PRKACA/NOTCH1/CARM1/AKT2/MAP2K2/CDK4/SHC1/PRKACB	-0.380448514936131
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1060	41/9376	0.862954440865163	MAOA/MAOB/SHMT2/GCSH	-0.313964875699978
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1060	41/9376	0.862954440865163	BABAM1/RPA2/SSBP1/RBBP8	-0.313964875699978
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1060	31/9376	0.855995130858186	HSD17B14/GUSB/ALDH9A1	-0.286714529286571
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/1060	156/9376	0.907208514755685	CD81/EGFR/CLDN5/IRF3/TRADD/IKBKG/TRAF2/YWHAE/FADD/STAT1/AKT2/RXRA/MAP2K2/CDK4/YWHAQ/PPP2R1A	-0.417240344546418
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1060	194/9376	0.911884847305972	MYL9/MYL6/TPM1/TPM2/DCTN5/ACTG1/DYNLL2/TUBA3E/KLC1/DYNC1LI2/DYNC1LI1/KIF1C/KIF2A/KIF21A/HOOK3/MYO19/DYNC2LI1/DCTN2/MYL6B/TUBG1	-0.442755688203946
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1060	71/9376	0.872070156789795	PRL/PRLR/STAT5B/STAT1/AKT2/MAP2K2/SHC1	-0.386299533555134
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/1060	138/9376	0.897347552638775	CDC16/PRKACA/SMC1A/PPP2R5A/PPP3CB/YWHAE/SMC3/PPP2R5B/SLK/YWHAQ/FBXW11/CALM2/PRKACB/PPP2R1A	-0.43371176458024
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/1060	110/9376	0.884528301886792	DCN/FBN1/EMP3/LTBP1/BMP8B/HDAC2/CREBBP/HDAC1/BMP4/ID4/PPP2R1A	-0.434917695024061
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/1060	42/9376	0.84240790655885	SLC40A1/GPX4/VDAC3/GCLC	-0.365431938843309
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/1060	52/9376	0.850507982583454	LRPAP1/APOA1/VDAC3/VAPB/STAR	-0.385922298467501
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/1060	32/9376	0.829245283018868	BECN1/FADD/BCL2L11	-0.345432037604642
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1060	72/9376	0.859958071278826	NFKBIB/OTUD5/IRF3/TRADD/IKBKG/TRAF2/FADD	-0.425863884614831
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1060	82/9376	0.862954440865163	GSTP1/NME1/NME6/GSTA1/GUSB/GMPS/UCK1/CES2	-0.444991678623395
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1060	53/9376	0.834460662157351	ATP2B4/PRKACA/RAB11A/CLTB/PRKACB	-0.431462084057759
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1060	63/9376	0.84240790655885	PTGDS/HPGD/GPX4/PTGES/TBXAS1/PTGR2	-0.44806521412438
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1060	54/9376	0.819007686932215	ERCC1/CENPX/RPA2/TELO2/REV3L	-0.47619386009377
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1060	23/9376	0.76915504511895	GOT2/ASS1	-0.395721975817814
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1060	23/9376	0.76915504511895	POMGNT1/RXYLT1	-0.395721975817814
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1060	23/9376	0.76915504511895	RPA2/SSBP1	-0.395721975817814
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1060	23/9376	0.76915504511895	LNPEP/NLN	-0.395721975817814
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1060	104/9376	0.850507982583454	AGPAT2/PLPP1/DGKZ/PCYT1A/GPAT4/AGPAT1/LPIN1/PISD/AGPAT5/PEMT	-0.547304843403431
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1060	75/9376	0.825559748427673	PRKACA/CREB1/CREB3/CREB3L1/GPX8/PRKACB/GPX3	-0.54149424379566
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/1060	105/9376	0.84240790655885	IL1R1/RELB/CCL21/TRADD/CSNK2A2/CSNK2B/IKBKG/TRAF2/LTB/PARP1	-0.579758486018064
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1060	12/9376	0.737106918238994	COQ6	-0.325327224808272
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/1060	76/9376	0.814697120158888	EGFR/AKT2/MAP2K2/CDK4/DDB2/SHC1/CALM2	-0.579067007007504
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1060	24/9376	0.737106918238994	B3GALT6/B3GAT3	-0.460377255662936
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/1060	212/9376	0.876183695265219	FLT1/F2R/RASGRP2/EGFR/KDR/ACTG1/CSF1R/ITGB1/CRKL/SIPA1L2/VEGFB/TLN1/PRKCI/CNR1/AKT2/MAP2K2/TIAM1/CRK/KRIT1/INSR/CALM2	-0.651005352298074
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/1060	67/9376	0.792114897212053	PRKACA/PPP3CB/CREBBP/MAP2K2/CALM2/PRKACB	-0.609664047869146
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/1060	68/9376	0.780466148723641	CSF1R/IKBKG/STAT5B/AKT2/MAP2K2/TCF7L2	-0.648648018640474
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/1060	119/9376	0.817631203424766	BCL3/CREB1/TRADD/FRMD8/CREB3/IKBKG/TRAF2/FADD/CREB3L1/AKT2/MAP3K5	-0.71477641114465
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1060	79/9376	0.783759254836398	NAPA/ATP6V0E2/ATP6V0D1/ATP6V0B/SYT1/CLTB/ATP6V1E1	-0.689066267375851
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1060	69/9376	0.76915504511895	PRKACA/ORAI1/CREB1/PPP3CB/CALM2/PRKACB	-0.687102306484038
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1060	26/9376	0.680406386066764	APOA1/TCN2	-0.582586332413556
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1060	50/9376	0.707622641509434	CD81/HBB/HBA2/THBS3	-0.740052219091254
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1060	39/9376	0.680406386066764	ATIC/SHMT2/GCSH	-0.714016170300859
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1060	103/9376	0.772888807473896	COL6A3/COL17A1/COL6A2/COL1A1/COL4A2/COL5A1/COL14A1/COL4A1/COL18A1	-0.827424451387398
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/1060	103/9376	0.772888807473896	SERPINE1/C1QB/IKBKG/FADD/AKT2/CD3D/CD3E/CD3G/PPP2R1A	-0.827424451387398
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/1060	93/9376	0.760884560762832	EGFR/MMP2/PRKACA/MAP3K3/MAP3K4/MAP2K2/CALM2/PRKACB	-0.827344240921738
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/1060	144/9376	0.79853249475891	FOXO1/C1QB/IRF3/TRADD/IKBKG/FADD/PRKAG1/ALDH9A1/AKT2/MAP3K5/IL17RC/LPIN1/TCF7L2	-0.869800568678884
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/1060	125/9376	0.778384905660377	SPTLC2/PDPK1/PPP2R5A/TRADD/TRAF2/AKT2/MAP2K2/MAP3K5/PPP2R5B/ORMDL3/PPP2R1A	-0.890515193683514
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/1060	116/9376	0.762524398178269	MYL9/THY1/MMP2/ACTG1/ARHGAP5/CLDN5/ITGB1/PTPN11/JAM2/VCL	-0.918806013039727
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/1060	168/9376	0.789757412398922	RBCK1/VDAC3/CAPN1/TRADD/TRAF2/VPS4A/STAT5B/FADD/STAT1/VPS4B/SHARPIN/TNFSF10/PARP1/SLC25A6/HMGB1	-0.981689190904401
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1060	86/9376	0.719964896884599	PRKACA/CREB1/CREB3/CREB3L1/SLC2A1/TRPM4/PRKACB	-0.93139772714325
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/1060	148/9376	0.776950535441101	EGFR/WNT4/NOTCH1/NCOA1/WNT5A/DVL2/AKT2/MAP2K2/CDK4/DDB2/SHC1/WNT10B/TCF7L2	-0.97647151828363
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/1060	98/9376	0.722063919907586	MTMR14/INPP5D/INPP1/DGKZ/INPPL1/PIP5K1A/ITPK1/CALM2	-0.987443174876754
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/1060	150/9376	0.766591194968554	EGFR/WNT4/WNT5A/DVL2/AKT2/RXRA/MAP2K2/RXRB/DDB2/GAB1/SHC1/WNT10B/TCF7L2	-1.02881543232217
NA	NA	hsa04981	Folate transport and metabolism	2/1060	31/9376	0.570663420572124	FOLR2/SHMT2	-0.854811618591492
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/1060	140/9376	0.758167115902965	RPS6/SERPINE1/PRKACA/BECN1/MEF2D/GNG12/PRKAG1/AKT2/MAP2K2/PIK3R4/CALM2/PRKACB	-1.02924494220337
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1060	66/9376	0.670097198399085	HSD11B1/CYP11A1/HSD17B11/SRD5A3/HSD3B1	-0.960206101836762
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/1060	77/9376	0.689242832639059	EGFR/IKBKG/STAT1/AKT2/CDK4/DDB2	-0.977529164297991
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1060	18/9376	0.491404612159329	ACSF3	-0.771078298068525
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/1060	78/9376	0.680406386066764	C1R/SERPING1/C1QB/ITGB1/IRF3/CALM2	-1.01188685370755
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/1060	89/9376	0.695696417214331	GJA1/EGFR/PRKACA/TJP1/TUBA3E/MAP2K2/PRKACB	-1.02978290190222
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1060	45/9376	0.589685534591195	ABCD1/ABCB7/ABCB8	-0.985009276866461
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/1060	133/9376	0.731564760959001	HLA-E/HLA-C/TYROBP/HLA-G/NFATC2/PPP3CB/PTPN11/MAP2K2/SHC1/TNFSF10/HLA-A	-1.1131154276076
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/1060	154/9376	0.746679735358981	TPM1/TPM2/ATP2B4/PRKACA/CREB1/PPP2R5A/CREB3/CREB3L1/AKT2/PPP2R5B/CALM2/PRKACB/PPP2R1A	-1.1316159627086
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1060	46/9376	0.576866283839212	GUSB/ALAD/FXN	-1.02706293528342
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/1060	187/9376	0.756815659368378	MFN2/NFKBIB/RBCK1/VDAC3/TRPV2/IRF3/GPSM3/TRIP6/GABARAP/IKBKG/TRAF2/YWHAE/FADD/STAT1/SHARPIN/GABARAPL2	-1.19923311941202
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1060	47/9376	0.564592533119229	HK1/PKM/INSR	-1.0683377768595
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/1060	59/9376	0.599680204669012	PRKACA/AKT2/INSR/PRKACB	-1.10122574135466
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1060	21/9376	0.421203953279425	PPCS	-0.947970097081658
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1060	36/9376	0.491404612159329	HK1/GANC	-1.09151965450503
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/1060	73/9376	0.605841302662186	EGFR/AKT2/MAP2K2/CDK4/DDB2	-1.20698636507952
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/1060	193/9376	0.73328771140874	CXCL14/RASGRP2/PRKACA/NFKBIB/CCL21/CRKL/WAS/IKBKG/GNG12/STAT5B/STAT1/AKT2/TIAM1/CRK/SHC1/PRKACB	-1.336628505486
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/1060	109/9376	0.649195083953609	TOLLIP/IRF3/IKBKG/FADD/STAT1/AKT2/CTSK/MAP2K2	-1.31519657353733
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1060	51/9376	0.52031076581576	PAFAH1B2/PLPP1/PAFAH2	-1.22631480063287
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/1060	87/9376	0.610019518542615	EGFR/AKT2/MAP2K2/DDB2/BCL2L11/TCF7L2	-1.30466600540323
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/1060	38/9376	0.465541211519364	PDPK1/INSR	-1.1785836632248
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/1060	89/9376	0.596311214755141	PRKACA/GABARAP/TRAK2/GNG12/GABARAPL2/PRKACB	-1.3661088210967
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/1060	134/9376	0.660095747676711	CALD1/MYL9/RAMP1/MYL6/PRKACA/MAP2K2/PPP1R12C/CALM2/PRKACB/MYL6B	-1.41484005150204
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1060	191/9376	0.694655734466067	PRKACA/SLC29A3/MAOA/CREB1/CREB3/HDAC6/HDAC2/GNG12/MAOB/CREB3L1/HDAC1/SHC1/SLC29A1/CALM2/PRKACB	-1.52211758022257
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1060	26/9376	0.340203193033382	ACAA1	-1.20274181069574
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1060	115/9376	0.61532403609516	PRKACA/CREB1/CREB3/GNG12/CREB3L1/AKT2/KCNQ3/PRKACB	-1.48182309522114
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1060	68/9376	0.52031076581576	ALDH1A2/DHRS3/DHRS4L2/RETSAT	-1.41731887591715
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/1060	56/9376	0.473854447439353	EEF1A1/VCP/HBS1L	-1.40985124296722
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/1060	69/9376	0.5127700300793	INPP5D/PDPK1/AKT2/MAP2K2	-1.45022374993279
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	17/1060	216/9376	0.696156533892383	APOA1/PDPK1/NFATC2/IRF3/POU2F1/NFATC3/PPP3CB/IKBKG/TRAF2/ATF6/AKT2/RXRA/MAP3K5/RXRB/TNFSF10/CALM2/MIB2	-1.612910877823
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1060	28/9376	0.315902964959569	QDPR	-1.29425157589868
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/1060	143/9376	0.618551260060694	HLA-DRB5/HLA-DRA/HLA-DPB1/C1R/HLA-DRB1/C1QB/HLA-DMB/SNRPD1/SNRPB/HLA-DPA1	-1.6410209143885
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1060	29/9376	0.305009759271308	CALM2	-1.3382058196917
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1060	73/9376	0.484673042129749	GSTP1/MAOA/GSTA1/MAOB	-1.578025845702
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/1060	168/9376	0.631805929919137	PRL/PRLR/EGFR/CCND3/CSH1/PTPN11/STAT5B/CSF2RA/CREBBP/STAT1/AKT2/IL2RB	-1.71921465996848
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1060	48/9376	0.368553459119497	HK1/AKT2	-1.56582877213362
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/1060	226/9376	0.665353147436968	MYL9/FXYD1/F2R/ATP2B4/PRKACA/ORAI1/CREB1/CREB3/CREB3L1/CREBBP/AKT2/MAP2K2/TIAM1/CALM2/PDE4A/PRKACB/OXT	-1.8180748024021
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/1060	76/9376	0.465541211519364	PRKACA/ACTG1/CALM2/PRKACB	-1.67017075654576
NA	NA	hsa04519	Cadherin signaling	34/1060	404/9376	0.74440500653839	KRT18/KRT8/KRT7/KRT19/GJA1/EGFR/KDR/WNT4/CDH11/ACTG1/DSP/APH1A/WNT5A/TJP1/ARPC5L/LHFPL6/IKBKG/DVL2/YWHAE/CREBBP/BRK1/MAP2K2/RERE/LATS2/TEAD1/NCKAP1/WWTR1/APH1B/WNT10B/VCL/TAOK2/TCF7L2/YWHAQ/ATN1	-1.87490696884879
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/1060	254/9376	0.661655028970435	FLT1/F2R/ATP2B4/EGFR/KDR/PRKACA/ORAI1/VDAC3/TFEB/NFATC2/NFATC3/PPP3CB/VEGFB/SLC25A6/TPCN1/CALM2/PRKACB/NFATC4/PHKG2	-1.95169918432156
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/1060	93/9376	0.47555285047677	CST3/ATP2B4/PRKACA/CALM2/PRKACB	-1.81459771150746
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/1060	94/9376	0.470493777599358	TRADD/IKBKG/TRAF2/FADD/IL17RC	-1.84202509804703
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/1060	144/9376	0.552830188679245	WNT4/WNT5A/DVL2/AKT2/MAP2K2/BMP4/PCGF1/ID4/WNT10B	-1.93057712069933
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1060	36/9376	0.245702306079665	GUSB	-1.61883252964102
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/1060	97/9376	0.455942423652986	PRKACA/CREB1/GNG12/CALM2/PRKACB	-1.92292113476882
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1060	70/9376	0.379083557951482	GSTP1/HSD11B1/GSTA1	-1.86158120972041
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/1060	217/9376	0.611425093470133	EGFR/PRKACA/CREB1/CCND3/GSTA1/CREB3/PAQR7/STAT5B/CREB3L1/KPNB1/AKT2/RXRA/MAP2K2/RXRB/PRKACB	-2.06757807953114
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/1060	99/9376	0.44673146559939	IL1R1/PRKACA/TRPV2/CALM2/PRKACB	-1.97574604447153
NA	NA	hsa04081	Hormone signaling	15/1060	219/9376	0.605841302662186	PRL/RAMP1/PRLR/SLC40A1/NPR3/PRKACA/ADRA2C/TRH/DIO2/CSH1/GNG12/STAT5B/INSR/PRKACB/OXT	-2.10716184985161
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/1060	100/9376	0.442264150943396	CXCL14/CSF1R/CCL21/TNFSF10/IL2RB	-2.00184072706501
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1060	90/9376	0.393123689727463	PRKACA/RXRA/SLC2A1/PRKACB	-2.06532513517764
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/1060	60/9376	0.294842767295597	MAP2K2/PPP2R1A	-1.95626723241292
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/1060	91/9376	0.388803649181008	PRKACA/GNG12/PDE4A/PRKACB	-2.09166353509341
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/1060	61/9376	0.290009279307145	ATP2B4/SLC40A1	-1.98612917552825
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/1060	195/9376	0.544325108853411	ACTG1/VDAC3/CLCN3/FGG/HDAC6/HDAC2/AKT2/VWF/MAP2K2/HDAC1/SLC25A6/HMGB1	-2.29566620533858
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/1060	298/9376	0.623325313410156	IL1RL1/PRL/PRLR/CXCL14/IL1R1/IL1R2/TNFRSF11B/CSF1R/CCL21/INHA/CSH1/BMP8B/CSF2RA/ACVRL1/IL16/TNFRSF21/BMP4/LTB/IL17RC/TNFSF10/IL2RB	-2.35917853932786
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1060	79/9376	0.335896823501314	GSTP1/HSD11B1/GSTA1	-2.11621124703478
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/1060	65/9376	0.272162554426705	AKT2/MAP2K2	-2.10220101181856
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/1060	115/9376	0.384577522559475	PRKACA/MAOA/GNG12/MAOB/PRKACB	-2.37068942684232
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/1060	110/9376	0.321646655231561	CDC16/PRKACA/AKT2/PRKACB	-2.5549799469417
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/1060	116/9376	0.305009759271308	PRKACA/PPP3CB/GNG12/PRKACB	-2.68895502227133
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1060	86/9376	0.205704256252742	PRKACA/PRKACB	-2.6418304068861
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/1060	102/9376	0.173436921938587	ATP2B4/RAB11A	-2.99656617122366
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	17/1060	323/9376	0.465541211519364	TIMP3/TPM1/EGFR/ZEB1/NOTCH1/TNXB/DNMT1/CRKL/HDAC2/PAK4/CREBBP/MAP2K2/HDAC1/BCL2L11/RASSF1/CRK/SHC1	-3.48980012894556
NA	NA	hsa04082	Neuroactive ligand signaling	5/1060	199/9376	0.222243291931355	TAC3/PRKACA/ADRA2C/GNG12/PRKACB	-3.95914373029658
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1060	370/9376	0.310780214176441	PRL/NPW/PRLR/F2R/TAC3/RXFP1/PGRMC1/ADRA2C/TRH/CSH1/CNR1/PGRMC2/OXT	-4.82918627565984
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1060	449/9376	0.0590998865403202	PRKACA/CALM2/PRKACB	-7.29449539609201