ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 97/2036 175/18639 0.554285714285714 5.07432781364019 1.33736101600361e-47 1.61018266326835e-44 GO:0019843 rRNA binding 30/2036 65/18639 0.461538461538462 4.22525313586217 7.47726693669783e-13 4.50131469589209e-10 GO:0005201 extracellular matrix structural constituent 48/2036 168/18639 0.285714285714286 2.61563289362896 2.20764940665026e-10 8.86003295202305e-08 GO:0005518 collagen binding 25/2036 72/18639 0.347222222222222 3.17872053045187 7.15032271287177e-08 2.1522471365744e-05 GO:0140104 molecular carrier activity 55/2036 249/18639 0.220883534136546 2.02212583141998 2.45445511544297e-07 5.15491785869614e-05 GO:0003713 transcription coactivator activity 56/2036 256/18639 0.21875 2.00259393418468 2.68834686597302e-07 5.15491785869614e-05 GO:0050840 extracellular matrix binding 23/2036 67/18639 0.343283582089552 3.14266340204674 2.9970452666838e-07 5.15491785869614e-05 GO:0045296 cadherin binding 67/2036 334/18639 0.20059880239521 1.8364248908862 5.80324367580439e-07 8.73388173208561e-05 GO:0019838 growth factor binding 35/2036 136/18639 0.257352941176471 2.35599286374668 9.42807872705915e-07 0.000126126742081991 GO:0031625 ubiquitin protein ligase binding 61/2036 302/18639 0.201986754966887 1.84913120129068 1.4431320637671e-06 0.000173753100477559 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 22/2036 68/18639 0.323529411764706 2.96181960013868 1.70256178652665e-06 0.000186353126452553 GO:0044389 ubiquitin-like protein ligase binding 62/2036 322/18639 0.192546583850932 1.76270912396735 6.10557057633607e-06 0.000612592247825719 GO:0032977 membrane insertase activity 9/2036 17/18639 0.529411764705882 4.84661389113602 2.33083587278814e-05 0.00215871260833609 GO:0001968 fibronectin binding 12/2036 30/18639 0.4 3.66188605108055 3.65897656697434e-05 0.00306201753088863 GO:0042608 T cell receptor binding 7/2036 11/18639 0.636363636363636 5.82572780853724 4.06912628689519e-05 0.00306201753088863 GO:1990948 ubiquitin ligase inhibitor activity 7/2036 11/18639 0.636363636363636 5.82572780853724 4.06912628689519e-05 0.00306201753088863 GO:0003712 transcription coregulator activity 83/2036 495/18639 0.167676767676768 1.53503304161457 4.54802854150164e-05 0.00322107433174587 GO:0008135 translation factor activity, RNA binding 22/2036 83/18639 0.265060240963855 2.42655099770398 5.82757968187379e-05 0.00370250645550527 GO:0140597 protein carrier chaperone 39/2036 188/18639 0.207446808510638 1.89911643606571 5.84282580187709e-05 0.00370250645550527 GO:0180051 translation factor activity 22/2036 84/18639 0.261904761904762 2.39766348582655 7.09061746177257e-05 0.00426855171198709 GO:0009055 electron transfer activity 27/2036 116/18639 0.232758620689655 2.13083886593049 0.000105615158611557 0.00605526909372924 GO:0019903 protein phosphatase binding 31/2036 144/18639 0.215277777777778 1.97080672888016 0.000159647716260125 0.00873708410805412 GO:0031994 insulin-like growth factor I binding 7/2036 13/18639 0.538461538461538 4.9294619918392 0.000173467350494329 0.00908063869544229 GO:0003743 translation initiation factor activity 15/2036 51/18639 0.294117647058824 2.69256327285335 0.000248794717867089 0.0124812016796656 GO:0008137 NADH dehydrogenase (ubiquinone) activity 13/2036 41/18639 0.317073170731707 2.9027145526858 0.000280561022201566 0.0135118188292274 GO:0023026 MHC class II protein complex binding 10/2036 27/18639 0.37037037037037 3.39063523248199 0.000345641595258793 0.0160058646419841 GO:0043130 ubiquitin binding 23/2036 100/18639 0.23 2.10558447937132 0.000399313532291252 0.0178064256621729 GO:0032182 ubiquitin-like protein binding 26/2036 120/18639 0.216666666666667 1.98352161100196 0.00046886705443131 0.0201612833405463 GO:0005520 insulin-like growth factor binding 8/2036 19/18639 0.421052631578947 3.85461689587426 0.000498047272078385 0.0206775488131854 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/2036 15/18639 0.466666666666667 4.27220039292731 0.00053368835256974 0.0214186925497989 GO:0003954 NADH dehydrogenase activity 13/2036 44/18639 0.295454545454545 2.70480219682086 0.000604718729532682 0.0231476980242161 GO:0048027 mRNA 5'-UTR binding 9/2036 24/18639 0.375 3.43301817288802 0.000615221209945942 0.0231476980242161 GO:0043236 laminin binding 10/2036 29/18639 0.344827586206897 3.15679831989703 0.000668937601490913 0.0244060870362139 GO:0019902 phosphatase binding 36/2036 190/18639 0.189473684210526 1.73457760314342 0.000690028060135723 0.0244351113059826 GO:0043021 ribonucleoprotein complex binding 34/2036 177/18639 0.192090395480226 1.75853284938896 0.000744399597623393 0.0256073461582447 GO:0022853 active monoatomic ion transmembrane transporter activity 25/2036 118/18639 0.211864406779661 1.93955828976724 0.000844167458098072 0.0282327116541688 GO:0019211 phosphatase activator activity 9/2036 25/18639 0.36 3.2956974459725 0.00086882099305253 0.0282719047468985 GO:0043022 ribosome binding 24/2036 112/18639 0.214285714285714 1.96172467022172 0.00089690638791488 0.0284177708170925 GO:0055106 ubiquitin-protein transferase regulator activity 11/2036 36/18639 0.305555555555556 2.79727406679764 0.00115420997956484 0.0356325337281041 GO:0140297 DNA-binding transcription factor binding 75/2036 488/18639 0.153688524590164 1.40697466101968 0.00142944988811167 0.0430264416321613 GO:0030515 snoRNA binding 10/2036 32/18639 0.3125 2.86084847740668 0.00158710815532153 0.0454971004525504 GO:0031369 translation initiation factor binding 10/2036 32/18639 0.3125 2.86084847740668 0.00158710815532153 0.0454971004525504 GO:0019208 phosphatase regulator activity 24/2036 117/18639 0.205128205128205 1.87789028260541 0.00169275461013457 0.0473971290837679 GO:0140098 catalytic activity, acting on RNA 61/2036 387/18639 0.157622739018088 1.44299127335861 0.00209422012674055 0.0573054780135369 GO:0031491 nucleosome binding 17/2036 74/18639 0.22972972972973 2.1031102320395 0.00220528197216083 0.0590035443218143 GO:0097177 mitochondrial ribosome binding 5/2036 10/18639 0.5 4.57735756385069 0.00243078440898284 0.0636231397481597 GO:0015078 proton transmembrane transporter activity 33/2036 185/18639 0.178378378378378 1.63300323899538 0.00313089073232514 0.0789974571806721 GO:0002020 protease binding 26/2036 136/18639 0.191176470588235 1.75016612735467 0.00314940028627264 0.0789974571806721 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 14/2036 58/18639 0.241379310344828 2.20975882392792 0.00323674780218199 0.0795315174250432 GO:0008201 heparin binding 31/2036 172/18639 0.180232558139535 1.64997772650432 0.00349251018080689 0.08409964515383 GO:0015399 primary active transmembrane transporter activity 30/2036 166/18639 0.180722891566265 1.65446658934362 0.00385516191427729 0.0910120577409777 GO:0043024 ribosomal small subunit binding 7/2036 20/18639 0.35 3.20415029469548 0.00393326559850312 0.0910702265499569 GO:0070990 snRNP binding 5/2036 11/18639 0.454545454545455 4.16123414895517 0.00405758221915099 0.092176018714298 GO:0042393 histone binding 41/2036 247/18639 0.165991902834008 1.51960858395043 0.0042216258295564 0.0941266203478871 GO:0003714 transcription corepressor activity 35/2036 204/18639 0.17156862745098 1.57066190916445 0.00459361007865793 0.100558300630984 GO:0042277 peptide binding 41/2036 249/18639 0.164658634538153 1.50740289251308 0.00487339860712019 0.104778070053084 GO:0005539 glycosaminoglycan binding 40/2036 242/18639 0.165289256198347 1.51317605416552 0.00502865780910114 0.106219368458908 GO:0023023 MHC protein complex binding 10/2036 37/18639 0.27027027027027 2.47424733181118 0.00516287438634112 0.107174151054391 GO:0019905 syntaxin binding 14/2036 61/18639 0.229508196721311 2.10108216045605 0.00526421170264566 0.107376741163291 GO:0072542 protein phosphatase activator activity 7/2036 21/18639 0.333333333333333 3.05157170923379 0.00535100039019724 0.107376741163291 GO:0019888 protein phosphatase regulator activity 21/2036 107/18639 0.196261682242991 1.79671979141803 0.00547351182351391 0.108034561237881 GO:0001221 transcription coregulator binding 22/2036 115/18639 0.191304347826087 1.75133680703852 0.00621510307554646 0.119182010061693 GO:0042162 telomeric DNA binding 10/2036 38/18639 0.263157894736842 2.40913555992141 0.0063341519108783 0.119182010061693 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2036 12/18639 0.416666666666667 3.81446463654224 0.0063352563487943 0.119182010061693 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/2036 22/18639 0.318181818181818 2.91286390426862 0.00711952136147124 0.131875441834021 GO:0097110 scaffold protein binding 15/2036 70/18639 0.214285714285714 1.96172467022172 0.00772718099283726 0.140962513869334 GO:0005178 integrin binding 28/2036 161/18639 0.173913043478261 1.59212437003502 0.00869861295597297 0.156315373119275 GO:0048487 beta-tubulin binding 10/2036 42/18639 0.238095238095238 2.17969407802414 0.0131870718125394 0.228702945406736 GO:0008191 metalloendopeptidase inhibitor activity 5/2036 14/18639 0.357142857142857 3.26954111703621 0.0132966828724846 0.228702945406736 GO:0016530 metallochaperone activity 5/2036 14/18639 0.357142857142857 3.26954111703621 0.0132966828724846 0.228702945406736 GO:0001222 transcription corepressor binding 11/2036 49/18639 0.224489795918367 2.05514013070847 0.0149039946104001 0.252738162125657 GO:0019213 deacetylase activity 9/2036 37/18639 0.243243243243243 2.22682259863006 0.0159118159312057 0.266080921960718 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/2036 20/18639 0.3 2.74641453831041 0.0169366173652779 0.275563341997225 GO:0031418 L-ascorbic acid binding 6/2036 20/18639 0.3 2.74641453831041 0.0169366173652779 0.275563341997225 GO:0004129 cytochrome-c oxidase activity 5/2036 15/18639 0.333333333333333 3.05157170923379 0.0181830343263173 0.282904145839288 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/2036 15/18639 0.333333333333333 3.05157170923379 0.0181830343263173 0.282904145839288 GO:0051371 muscle alpha-actinin binding 5/2036 15/18639 0.333333333333333 3.05157170923379 0.0181830343263173 0.282904145839288 GO:0003724 RNA helicase activity 15/2036 77/18639 0.194805194805195 1.78338606383793 0.0183276772221465 0.282904145839288 GO:0140142 nucleocytoplasmic carrier activity 8/2036 32/18639 0.25 2.28867878192534 0.0191292941392425 0.291540128400607 GO:0140713 histone chaperone activity 27/2036 164/18639 0.164634146341463 1.5071787100484 0.0195433289957912 0.294127101386657 GO:0019207 kinase regulator activity 43/2036 287/18639 0.149825783972125 1.37161237104933 0.0199775959283196 0.296950932070331 GO:0031490 chromatin DNA binding 22/2036 128/18639 0.171875 1.57346666257367 0.0209591086638767 0.307241084674489 GO:0042605 peptide antigen binding 10/2036 45/18639 0.222222222222222 2.03438113948919 0.0211802408870287 0.307241084674489 GO:0160215 deacylase activity 13/2036 65/18639 0.2 1.83094302554028 0.0219912986654099 0.313508223984762 GO:0016779 nucleotidyltransferase activity 23/2036 136/18639 0.169117647058824 1.54822388189067 0.0221330556799873 0.313508223984762 GO:0008186 ATP-dependent activity, acting on RNA 15/2036 79/18639 0.189873417721519 1.73823704956355 0.0227998565324666 0.319197991454533 GO:0031593 polyubiquitin modification-dependent protein binding 12/2036 59/18639 0.203389830508475 1.86197595817655 0.0239925504235806 0.325696601697807 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/2036 16/18639 0.3125 2.86084847740668 0.0241195992918636 0.325696601697807 GO:0017070 U6 snRNA binding 5/2036 16/18639 0.3125 2.86084847740668 0.0241195992918636 0.325696601697807 GO:1901681 sulfur compound binding 41/2036 275/18639 0.149090909090909 1.3648848008573 0.0243460914890387 0.325696601697807 GO:0051020 GTPase binding 46/2036 315/18639 0.146031746031746 1.33687903452147 0.0250131630804198 0.330943388448631 GO:0061775 cohesin loader activity 25/2036 153/18639 0.163398692810458 1.49586848491853 0.0260345053448811 0.340712439513444 GO:0034062 5'-3' RNA polymerase activity 6/2036 22/18639 0.272727272727273 2.4967404893731 0.0269901177029998 0.345703209727784 GO:0097747 RNA polymerase activity 6/2036 22/18639 0.272727272727273 2.4967404893731 0.0269901177029998 0.345703209727784 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 50/2036 349/18639 0.143266475644699 1.31156377187699 0.0276467895617811 0.347707765017903 GO:0016651 oxidoreductase activity, acting on NAD(P)H 16/2036 88/18639 0.181818181818182 1.66449365958207 0.0278783793284713 0.347707765017903 GO:0003684 damaged DNA binding 14/2036 74/18639 0.189189189189189 1.73197313226783 0.0280130010022729 0.347707765017903 GO:0004857 enzyme inhibitor activity 58/2036 416/18639 0.139423076923077 1.27637855145836 0.0307161742508478 0.375308157853278 GO:1990841 promoter-specific chromatin binding 13/2036 68/18639 0.191176470588235 1.75016612735467 0.0309692745436305 0.375308157853278 GO:1990226 histone methyltransferase binding 5/2036 17/18639 0.294117647058824 2.69256327285335 0.0311717739080796 0.375308157853278 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 10/2036 48/18639 0.208333333333333 1.90723231827112 0.0322174893467839 0.384057991817107 GO:0004602 glutathione peroxidase activity 6/2036 23/18639 0.260869565217391 2.38818655505253 0.0332385544230804 0.384800187744124 GO:0042171 lysophosphatidic acid acyltransferase activity 6/2036 23/18639 0.260869565217391 2.38818655505253 0.0332385544230804 0.384800187744124 GO:0071617 lysophospholipid acyltransferase activity 6/2036 23/18639 0.260869565217391 2.38818655505253 0.0332385544230804 0.384800187744124 GO:0003779 actin binding 61/2036 443/18639 0.137697516930023 1.26058154128619 0.034019718699669 0.388227278915961 GO:0005049 nuclear export signal receptor activity 4/2036 12/18639 0.333333333333333 3.05157170923379 0.0342390062421705 0.388227278915961 GO:0004402 histone acetyltransferase activity 9/2036 42/18639 0.214285714285714 1.96172467022172 0.034824373856249 0.388227278915961 GO:0031492 nucleosomal DNA binding 9/2036 42/18639 0.214285714285714 1.96172467022172 0.034824373856249 0.388227278915961 GO:0140658 ATP-dependent chromatin remodeler activity 25/2036 158/18639 0.158227848101266 1.44853087463629 0.0368020276754908 0.395193405159003 GO:0019212 phosphatase inhibitor activity 11/2036 56/18639 0.196428571428571 1.79824761436991 0.0377179967813941 0.395193405159003 GO:0000149 SNARE binding 18/2036 106/18639 0.169811320754717 1.55457426696816 0.0381698372666692 0.395193405159003 GO:0000510 H3-H4 histone complex chaperone activity 24/2036 151/18639 0.158940397350993 1.45505406003201 0.0383454081928625 0.395193405159003 GO:0140584 chromatin extrusion motor activity 24/2036 151/18639 0.158940397350993 1.45505406003201 0.0383454081928625 0.395193405159003 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 24/2036 151/18639 0.158940397350993 1.45505406003201 0.0383454081928625 0.395193405159003 GO:0140849 ATP-dependent H2AZ histone chaperone activity 24/2036 151/18639 0.158940397350993 1.45505406003201 0.0383454081928625 0.395193405159003 GO:0051721 protein phosphatase 2A binding 7/2036 30/18639 0.233333333333333 2.13610019646365 0.0393019301803576 0.395193405159003 GO:0003746 translation elongation factor activity 5/2036 18/18639 0.277777777777778 2.54297642436149 0.0393880470258143 0.395193405159003 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 5/2036 18/18639 0.277777777777778 2.54297642436149 0.0393880470258143 0.395193405159003 GO:0050811 GABA receptor binding 5/2036 18/18639 0.277777777777778 2.54297642436149 0.0393880470258143 0.395193405159003 GO:0070064 proline-rich region binding 5/2036 18/18639 0.277777777777778 2.54297642436149 0.0393880470258143 0.395193405159003 GO:0019955 cytokine binding 23/2036 144/18639 0.159722222222222 1.46221144400786 0.039934367055998 0.397363454011749 GO:0050431 transforming growth factor beta binding 6/2036 24/18639 0.25 2.28867878192534 0.0403520325037725 0.397874897961636 GO:0015616 DNA translocase activity 24/2036 152/18639 0.157894736842105 1.44548133595285 0.0409963026612351 0.397874897961636 GO:0140674 ATP-dependent histone chaperone activity 24/2036 152/18639 0.157894736842105 1.44548133595285 0.0409963026612351 0.397874897961636 GO:0000287 magnesium ion binding 34/2036 230/18639 0.147826086956522 1.35330571452977 0.0416515573446286 0.397874897961636 GO:0003689 DNA clamp loader activity 25/2036 160/18639 0.15625 1.43042423870334 0.0419330058948246 0.397874897961636 GO:0004601 peroxidase activity 11/2036 57/18639 0.192982456140351 1.76669941060904 0.0422989924743267 0.397874897961636 GO:0016504 peptidase activator activity 11/2036 57/18639 0.192982456140351 1.76669941060904 0.0422989924743267 0.397874897961636 GO:0019205 nucleobase-containing compound kinase activity 9/2036 44/18639 0.204545454545455 1.87255536702983 0.0455139078144543 0.420945138149502 GO:0030020 extracellular matrix structural constituent conferring tensile strength 9/2036 44/18639 0.204545454545455 1.87255536702983 0.0455139078144543 0.420945138149502 GO:0046332 SMAD binding 14/2036 79/18639 0.177215189873418 1.62235457959265 0.0459463729488698 0.420945138149502 GO:0070325 lipoprotein particle receptor binding 7/2036 31/18639 0.225806451612903 2.06719373851321 0.0461501314250285 0.420945138149502 GO:0003707 nuclear steroid receptor activity 6/2036 25/18639 0.24 2.19713163064833 0.0483575990820515 0.42810698010875 GO:0004709 MAP kinase kinase kinase activity 6/2036 25/18639 0.24 2.19713163064833 0.0483575990820515 0.42810698010875 GO:0042974 nuclear retinoic acid receptor binding 6/2036 25/18639 0.24 2.19713163064833 0.0483575990820515 0.42810698010875 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/2036 25/18639 0.24 2.19713163064833 0.0483575990820515 0.42810698010875 GO:0061134 peptidase regulator activity 33/2036 226/18639 0.146017699115044 1.33675043900064 0.0510820515839015 0.448925475233703 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/2036 59/18639 0.186440677966102 1.70681129499517 0.0525788862432292 0.458731732151072 GO:0034237 protein kinase A regulatory subunit binding 6/2036 26/18639 0.230769230769231 2.11262656793109 0.0572732214720659 0.48659915714169 GO:0050750 low-density lipoprotein particle receptor binding 6/2036 26/18639 0.230769230769231 2.11262656793109 0.0572732214720659 0.48659915714169 GO:0032036 myosin heavy chain binding 4/2036 14/18639 0.285714285714286 2.61563289362896 0.0580842300317526 0.48659915714169 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/2036 60/18639 0.183333333333333 1.67836444007859 0.0582968127875024 0.48659915714169 GO:0004864 protein phosphatase inhibitor activity 10/2036 53/18639 0.188679245283019 1.72730474107573 0.0586020579614162 0.48659915714169 GO:0016860 intramolecular oxidoreductase activity 10/2036 53/18639 0.188679245283019 1.72730474107573 0.0586020579614162 0.48659915714169 GO:0034212 protein N-acetyltransferase activity 10/2036 53/18639 0.188679245283019 1.72730474107573 0.0586020579614162 0.48659915714169 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 33/2036 229/18639 0.14410480349345 1.31923842451592 0.0593783458991357 0.486683300898651 GO:0000339 RNA cap binding 5/2036 20/18639 0.25 2.28867878192534 0.0594206355748352 0.486683300898651 GO:0140416 transcription regulator inhibitor activity 7/2036 33/18639 0.212121212121212 1.94190926951241 0.0620123574362374 0.504478907792094 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 8/2036 40/18639 0.2 1.83094302554028 0.0644113312149786 0.5138604814384 GO:0001540 amyloid-beta binding 14/2036 83/18639 0.168674698795181 1.54416881672071 0.0651480347154589 0.5138604814384 GO:0017069 snRNA binding 10/2036 54/18639 0.185185185185185 1.695317616241 0.0651895774990556 0.5138604814384 GO:0051287 NAD binding 10/2036 54/18639 0.185185185185185 1.695317616241 0.0651895774990556 0.5138604814384 GO:0061733 protein-lysine-acetyltransferase activity 9/2036 47/18639 0.191489361702128 1.75303055636835 0.0652995462292983 0.5138604814384 GO:0017022 myosin binding 13/2036 76/18639 0.171052631578947 1.56593811394892 0.0672643356459419 0.525884805959182 GO:0016922 nuclear receptor binding 21/2036 137/18639 0.153284671532847 1.40327750132649 0.068918267739416 0.535339318440367 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 19/2036 122/18639 0.155737704918033 1.42573432316661 0.0710026007666271 0.540372610649277 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/2036 34/18639 0.205882352941176 1.88479429099734 0.071046612299254 0.540372610649277 GO:0031386 protein tag activity 4/2036 15/18639 0.266666666666667 2.44125736738703 0.0725937557428202 0.540372610649277 GO:0141047 molecular tag activity 4/2036 15/18639 0.266666666666667 2.44125736738703 0.0725937557428202 0.540372610649277 GO:0141050 histone H3K deacetylase activity 4/2036 15/18639 0.266666666666667 2.44125736738703 0.0725937557428202 0.540372610649277 GO:0141051 histone H4K deacetylase activity 4/2036 15/18639 0.266666666666667 2.44125736738703 0.0725937557428202 0.540372610649277 GO:0140318 protein transporter activity 8/2036 41/18639 0.195121951219512 1.78628587857588 0.0727079426288894 0.540372610649277 GO:0052689 carboxylic ester hydrolase activity 15/2036 92/18639 0.16304347826087 1.49261659690783 0.0735180822660868 0.54304154017404 GO:0031267 small GTPase binding 39/2036 283/18639 0.137809187279152 1.26160385152068 0.0758650948262707 0.556960818114816 GO:0005507 copper ion binding 11/2036 63/18639 0.174603174603175 1.59844232388437 0.0778473261690149 0.558003237614047 GO:0036408 histone H3K14 acetyltransferase activity 6/2036 28/18639 0.214285714285714 1.96172467022172 0.0778609168763787 0.558003237614047 GO:0046966 nuclear thyroid hormone receptor binding 6/2036 28/18639 0.214285714285714 1.96172467022172 0.0778609168763787 0.558003237614047 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/2036 28/18639 0.214285714285714 1.96172467022172 0.0778609168763787 0.558003237614047 GO:0004386 helicase activity 23/2036 155/18639 0.148387096774194 1.3584415995944 0.0791460915339893 0.563857362171143 GO:0010485 histone H4 acetyltransferase activity 7/2036 35/18639 0.2 1.83094302554028 0.080820408691772 0.565684919246131 GO:0004407 histone deacetylase activity 5/2036 22/18639 0.227272727272727 2.08061707447759 0.0842659160376829 0.565684919246131 GO:0033558 protein lysine deacetylase activity 5/2036 22/18639 0.227272727272727 2.08061707447759 0.0842659160376829 0.565684919246131 GO:0070034 telomerase RNA binding 5/2036 22/18639 0.227272727272727 2.08061707447759 0.0842659160376829 0.565684919246131 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0016783 sulfurtransferase activity 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0032395 MHC class II receptor activity 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0033204 ribonuclease P RNA binding 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0042975 peroxisome proliferator activated receptor binding 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0098505 G-rich strand telomeric DNA binding 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2036 10/18639 0.3 2.74641453831041 0.0869200249672211 0.565684919246131 GO:0140030 modification-dependent protein binding 25/2036 173/18639 0.144508670520231 1.32293571209557 0.0886332461749701 0.56681013374247 GO:0097027 ubiquitin-protein transferase activator activity 4/2036 16/18639 0.25 2.28867878192534 0.0887518078931391 0.56681013374247 GO:0010484 histone H3 acetyltransferase activity 6/2036 29/18639 0.206896551724138 1.89407899193822 0.0895238718402906 0.56681013374247 GO:0016417 S-acyltransferase activity 6/2036 29/18639 0.206896551724138 1.89407899193822 0.0895238718402906 0.56681013374247 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/2036 43/18639 0.186046511627907 1.70320281445607 0.0911518048540737 0.56681013374247 GO:0016409 palmitoyltransferase activity 7/2036 36/18639 0.194444444444444 1.78008349705305 0.0913298720482053 0.56681013374247 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/2036 36/18639 0.194444444444444 1.78008349705305 0.0913298720482053 0.56681013374247 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/2036 36/18639 0.194444444444444 1.78008349705305 0.0913298720482053 0.56681013374247 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/2036 36/18639 0.194444444444444 1.78008349705305 0.0913298720482053 0.56681013374247 GO:0019887 protein kinase regulator activity 35/2036 255/18639 0.137254901960784 1.25652952733156 0.0924418929239361 0.570769431181636 GO:0008408 3'-5' exonuclease activity 10/2036 58/18639 0.172413793103448 1.57839915994851 0.0961289614054186 0.590506477204714 GO:0016407 acetyltransferase activity 15/2036 96/18639 0.15625 1.43042423870334 0.0980040734117427 0.597294937807281 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 24/2036 167/18639 0.143712574850299 1.31564768302295 0.0982262439251177 0.597294937807281 GO:0005048 signal sequence binding 9/2036 51/18639 0.176470588235294 1.61553796371201 0.0990060881374801 0.599011709133297 GO:0001223 transcription coactivator binding 8/2036 44/18639 0.181818181818182 1.66449365958207 0.101293559751767 0.605436187858865 GO:0043995 histone H4K5 acetyltransferase activity 6/2036 30/18639 0.2 1.83094302554028 0.102079357255274 0.605436187858865 GO:0043996 histone H4K8 acetyltransferase activity 6/2036 30/18639 0.2 1.83094302554028 0.102079357255274 0.605436187858865 GO:0043997 histone H4K12 acetyltransferase activity 6/2036 30/18639 0.2 1.83094302554028 0.102079357255274 0.605436187858865 GO:0061135 endopeptidase regulator activity 26/2036 184/18639 0.141304347826087 1.29360105065345 0.102600167745707 0.605542166499174 GO:0004549 tRNA-specific ribonuclease activity 4/2036 17/18639 0.235294117647059 2.15405061828268 0.106468741427004 0.605647051935377 GO:0004659 prenyltransferase activity 4/2036 17/18639 0.235294117647059 2.15405061828268 0.106468741427004 0.605647051935377 GO:0005092 GDP-dissociation inhibitor activity 4/2036 17/18639 0.235294117647059 2.15405061828268 0.106468741427004 0.605647051935377 GO:0051787 misfolded protein binding 4/2036 17/18639 0.235294117647059 2.15405061828268 0.106468741427004 0.605647051935377 GO:0003697 single-stranded DNA binding 18/2036 121/18639 0.148760330578512 1.36185844874896 0.108254890296492 0.605647051935377 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0019107 myristoyltransferase activity 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0019206 nucleoside kinase activity 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0048185 activin binding 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0048407 platelet-derived growth factor binding 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0050786 RAGE receptor binding 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0050998 nitric-oxide synthase binding 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0140537 transcription regulator activator activity 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2036 11/18639 0.272727272727273 2.4967404893731 0.110163375725787 0.605647051935377 GO:0001098 basal transcription machinery binding 10/2036 60/18639 0.166666666666667 1.5257858546169 0.114360715658517 0.62303303915319 GO:0001099 basal RNA polymerase II transcription machinery binding 10/2036 60/18639 0.166666666666667 1.5257858546169 0.114360715658517 0.62303303915319 GO:0005164 tumor necrosis factor receptor binding 6/2036 31/18639 0.193548387096774 1.77188034729704 0.115502371454533 0.626418266807466 GO:0140097 catalytic activity, acting on DNA 44/2036 336/18639 0.130952380952381 1.19883174291328 0.116721501228073 0.630191423670849 GO:0051018 protein kinase A binding 9/2036 53/18639 0.169811320754717 1.55457426696816 0.119004444802347 0.636806006853449 GO:1901505 carbohydrate derivative transmembrane transporter activity 9/2036 53/18639 0.169811320754717 1.55457426696816 0.119004444802347 0.636806006853449 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 8/2036 46/18639 0.173913043478261 1.59212437003502 0.12337536155975 0.649741665476038 GO:0004706 JUN kinase kinase kinase activity 4/2036 18/18639 0.222222222222222 2.03438113948919 0.125634654113057 0.649741665476038 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 7/2036 39/18639 0.179487179487179 1.64315399727973 0.127153892793117 0.649741665476038 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/2036 39/18639 0.179487179487179 1.64315399727973 0.127153892793117 0.649741665476038 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 19/2036 132/18639 0.143939393939394 1.31772414716914 0.128168966124035 0.649741665476038 GO:0051059 NF-kappaB binding 6/2036 32/18639 0.1875 1.71650908644401 0.129760772744414 0.649741665476038 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/2036 25/18639 0.2 1.83094302554028 0.13006877346301 0.649741665476038 GO:0019707 protein-cysteine S-acyltransferase activity 5/2036 25/18639 0.2 1.83094302554028 0.13006877346301 0.649741665476038 GO:0051540 metal cluster binding 12/2036 77/18639 0.155844155844156 1.42670885107034 0.130731764611343 0.649741665476038 GO:0043495 protein-membrane adaptor activity 8/2036 47/18639 0.170212765957447 1.55824938343853 0.135288349319843 0.649741665476038 GO:0140938 histone H3 methyltransferase activity 8/2036 47/18639 0.170212765957447 1.55824938343853 0.135288349319843 0.649741665476038 GO:0003995 acyl-CoA dehydrogenase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0004526 ribonuclease P activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0016273 arginine N-methyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0016274 protein-arginine N-methyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0031543 peptidyl-proline dioxygenase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0036009 protein-glutamine N-methyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0043047 single-stranded telomeric DNA binding 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0097371 MDM2/MDM4 family protein binding 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2036 12/18639 0.25 2.28867878192534 0.135471498886993 0.649741665476038 GO:1990782 protein tyrosine kinase binding 17/2036 117/18639 0.145299145299145 1.33017228351217 0.135533054559868 0.649741665476038 GO:0016741 transferase activity, transferring one-carbon groups 29/2036 215/18639 0.134883720930233 1.23482204048065 0.135992441611264 0.649741665476038 GO:0019199 transmembrane receptor protein kinase activity 12/2036 78/18639 0.153846153846154 1.40841771195406 0.140050363327259 0.66648473298822 GO:0140313 molecular sequestering activity 9/2036 55/18639 0.163636363636364 1.49804429362386 0.141024180947178 0.668476826222055 GO:0016209 antioxidant activity 13/2036 86/18639 0.151162790697674 1.38385228674556 0.141632806014547 0.668729013496136 GO:0019787 ubiquitin-like protein transferase activity 60/2036 479/18639 0.125260960334029 1.14672840848034 0.143826454712536 0.67150110037817 GO:0016874 ligase activity 23/2036 167/18639 0.137724550898204 1.26082902956366 0.144803367802193 0.67150110037817 GO:0140311 protein sequestering activity 6/2036 33/18639 0.181818181818182 1.66449365958207 0.144815976146231 0.67150110037817 GO:0031420 alkali metal ion binding 4/2036 19/18639 0.210526315789474 1.92730844793713 0.146123993603887 0.67150110037817 GO:0042800 histone H3K4 methyltransferase activity 4/2036 19/18639 0.210526315789474 1.92730844793713 0.146123993603887 0.67150110037817 GO:0070003 threonine-type peptidase activity 4/2036 19/18639 0.210526315789474 1.92730844793713 0.146123993603887 0.67150110037817 GO:0097001 ceramide binding 4/2036 19/18639 0.210526315789474 1.92730844793713 0.146123993603887 0.67150110037817 GO:0005112 Notch binding 5/2036 26/18639 0.192307692307692 1.76052213994257 0.147401047746568 0.67223811169268 GO:0008157 protein phosphatase 1 binding 5/2036 26/18639 0.192307692307692 1.76052213994257 0.147401047746568 0.67223811169268 GO:0008017 microtubule binding 36/2036 276/18639 0.130434782608696 1.19409327752627 0.149295147032839 0.677859154089632 GO:0004519 endonuclease activity 18/2036 127/18639 0.141732283464567 1.29751867951673 0.150322586496621 0.677859154089632 GO:0042826 histone deacetylase binding 18/2036 127/18639 0.141732283464567 1.29751867951673 0.150322586496621 0.677859154089632 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/2036 41/18639 0.170731707317073 1.56300014375389 0.154412475378556 0.693703807297693 GO:0048306 calcium-dependent protein binding 12/2036 80/18639 0.15 1.37320726915521 0.159720419525585 0.69637737023946 GO:0004866 endopeptidase inhibitor activity 22/2036 161/18639 0.136645962732919 1.25095486217037 0.159868253428428 0.69637737023946 GO:0008376 acetylgalactosaminyltransferase activity 6/2036 34/18639 0.176470588235294 1.61553796371201 0.160623696970583 0.69637737023946 GO:0004842 ubiquitin-protein transferase activity 56/2036 449/18639 0.124721603563474 1.14179075089371 0.161233668389199 0.69637737023946 GO:0002161 aminoacyl-tRNA editing activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0004535 poly(A)-specific ribonuclease activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0019104 DNA N-glycosylase activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0030955 potassium ion binding 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0089720 caspase binding 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2036 13/18639 0.230769230769231 2.11262656793109 0.162526612157216 0.69637737023946 GO:0008320 protein transmembrane transporter activity 5/2036 27/18639 0.185185185185185 1.695317616241 0.165649530176783 0.701519425531545 GO:0015252 proton channel activity 5/2036 27/18639 0.185185185185185 1.695317616241 0.165649530176783 0.701519425531545 GO:0035591 signaling adaptor activity 18/2036 129/18639 0.13953488372093 1.27740211084205 0.166108446997651 0.701519425531545 GO:0004674 protein serine/threonine kinase activity 54/2036 433/18639 0.124711316397229 1.14169657481726 0.166390864671086 0.701519425531545 GO:0004540 RNA nuclease activity 17/2036 121/18639 0.140495867768595 1.28619964604069 0.167390611308668 0.701519425531545 GO:0061608 nuclear import signal receptor activity 4/2036 20/18639 0.2 1.83094302554028 0.16779983311115 0.701519425531545 GO:0016859 cis-trans isomerase activity 7/2036 42/18639 0.166666666666667 1.5257858546169 0.168970625750954 0.701519425531545 GO:0042056 chemoattractant activity 7/2036 42/18639 0.166666666666667 1.5257858546169 0.168970625750954 0.701519425531545 GO:0051879 Hsp90 protein binding 7/2036 42/18639 0.166666666666667 1.5257858546169 0.168970625750954 0.701519425531545 GO:0030971 receptor tyrosine kinase binding 12/2036 81/18639 0.148148148148148 1.3562540929928 0.170054859806097 0.703371818818134 GO:0030246 carbohydrate binding 36/2036 280/18639 0.128571428571429 1.17703480213303 0.170585191939282 0.703371818818134 GO:0005006 epidermal growth factor receptor activity 8/2036 50/18639 0.16 1.46475442043222 0.174286507927776 0.713744746751843 GO:0032813 tumor necrosis factor receptor superfamily binding 8/2036 50/18639 0.16 1.46475442043222 0.174286507927776 0.713744746751843 GO:0016853 isomerase activity 24/2036 180/18639 0.133333333333333 1.22062868369352 0.176933063173941 0.716926354905337 GO:0000175 3'-5'-RNA exonuclease activity 6/2036 35/18639 0.171428571428571 1.56937973617738 0.177134722131716 0.716926354905337 GO:0016229 steroid dehydrogenase activity 6/2036 35/18639 0.171428571428571 1.56937973617738 0.177134722131716 0.716926354905337 GO:0016755 aminoacyltransferase activity 61/2036 496/18639 0.122983870967742 1.12588230401166 0.177445227376902 0.716926354905337 GO:0008170 N-methyltransferase activity 14/2036 98/18639 0.142857142857143 1.30781644681448 0.179680056707522 0.723527719986141 GO:0008200 ion channel inhibitor activity 7/2036 43/18639 0.162790697674419 1.49030246264906 0.184102063147569 0.731643913290031 GO:0008375 acetylglucosaminyltransferase activity 7/2036 43/18639 0.162790697674419 1.49030246264906 0.184102063147569 0.731643913290031 GO:0019789 SUMO transferase activity 5/2036 28/18639 0.178571428571429 1.6347705585181 0.184734011329044 0.731643913290031 GO:0046625 sphingolipid binding 5/2036 28/18639 0.178571428571429 1.6347705585181 0.184734011329044 0.731643913290031 GO:0051393 alpha-actinin binding 5/2036 28/18639 0.178571428571429 1.6347705585181 0.184734011329044 0.731643913290031 GO:0005010 insulin-like growth factor receptor activity 8/2036 51/18639 0.156862745098039 1.43603374552178 0.188292167423644 0.739476274670373 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/2036 21/18639 0.19047619047619 1.74375526241931 0.190517749338848 0.739476274670373 GO:0004879 nuclear receptor activity 9/2036 59/18639 0.152542372881356 1.39648196863241 0.190666075321723 0.739476274670373 GO:0031404 chloride ion binding 3/2036 14/18639 0.214285714285714 1.96172467022172 0.191010898191434 0.739476274670373 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/2036 14/18639 0.214285714285714 1.96172467022172 0.191010898191434 0.739476274670373 GO:0046030 inositol trisphosphate phosphatase activity 3/2036 14/18639 0.214285714285714 1.96172467022172 0.191010898191434 0.739476274670373 GO:0098847 sequence-specific single stranded DNA binding 3/2036 14/18639 0.214285714285714 1.96172467022172 0.191010898191434 0.739476274670373 GO:0008173 RNA methyltransferase activity 10/2036 67/18639 0.149253731343284 1.36637539219423 0.191798191708711 0.740144303901562 GO:0016757 glycosyltransferase activity 34/2036 267/18639 0.127340823970037 1.16576896757246 0.193882995343769 0.742641312211731 GO:0005484 SNAP receptor activity 6/2036 36/18639 0.166666666666667 1.5257858546169 0.194295692148418 0.742641312211731 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2036 36/18639 0.166666666666667 1.5257858546169 0.194295692148418 0.742641312211731 GO:0016248 channel inhibitor activity 7/2036 44/18639 0.159090909090909 1.45643195213431 0.199768536762991 0.753835200268018 GO:0016790 thiolester hydrolase activity 7/2036 44/18639 0.159090909090909 1.45643195213431 0.199768536762991 0.753835200268018 GO:0043178 alcohol binding 13/2036 92/18639 0.141304347826087 1.29360105065345 0.201519182968423 0.753835200268018 GO:0004518 nuclease activity 27/2036 209/18639 0.129186602870813 1.18266654759779 0.203757579490279 0.753835200268018 GO:0051536 iron-sulfur cluster binding 11/2036 76/18639 0.144736842105263 1.32502455795678 0.203947353760481 0.753835200268018 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/2036 60/18639 0.15 1.37320726915521 0.204131727026995 0.753835200268018 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/2036 60/18639 0.15 1.37320726915521 0.204131727026995 0.753835200268018 GO:0098531 ligand-modulated transcription factor activity 9/2036 60/18639 0.15 1.37320726915521 0.204131727026995 0.753835200268018 GO:0008094 ATP-dependent activity, acting on DNA 27/2036 210/18639 0.128571428571429 1.17703480213303 0.210948964964297 0.753835200268018 GO:0051213 dioxygenase activity 13/2036 93/18639 0.139784946236559 1.27969136193675 0.212479317334392 0.753835200268018 GO:0051219 phosphoprotein binding 13/2036 93/18639 0.139784946236559 1.27969136193675 0.212479317334392 0.753835200268018 GO:0008649 rRNA methyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0032931 histone H3K56 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0043992 histone H3K9 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0043993 histone H3K18 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0043994 histone H3K23 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0043999 histone H2AK5 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044012 histone H2AK9 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044014 histone H2BK5 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044015 histone H2BK12 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044016 histone H3K4 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044017 histone H3K27 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0044018 histone H3K36 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0046972 histone H4K16 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0061133 endopeptidase activator activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0140035 ubiquitin-like protein reader activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0140908 histone H3K122 acetyltransferase activity 4/2036 22/18639 0.181818181818182 1.66449365958207 0.214129267850218 0.753835200268018 GO:0141110 transporter inhibitor activity 7/2036 45/18639 0.155555555555556 1.42406679764244 0.215929297697843 0.757955902123041 GO:0008080 N-acetyltransferase activity 10/2036 69/18639 0.144927536231884 1.32677030836252 0.217379799707253 0.758916232284338 GO:0004559 alpha-mannosidase activity 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0005523 tropomyosin binding 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0033130 acetylcholine receptor binding 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0042809 nuclear vitamin D receptor binding 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0045504 dynein heavy chain binding 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0050780 dopamine receptor binding 3/2036 15/18639 0.2 1.83094302554028 0.220615183803587 0.758916232284338 GO:0030414 peptidase inhibitor activity 22/2036 169/18639 0.130177514792899 1.19173806396113 0.221541055610597 0.759930002721249 GO:0030695 GTPase regulator activity 59/2036 489/18639 0.120654396728016 1.10455663094965 0.225089366949433 0.769907948315675 GO:0050660 flavin adenine dinucleotide binding 12/2036 86/18639 0.13953488372093 1.27740211084205 0.226285549524946 0.771806803478854 GO:0008168 methyltransferase activity 26/2036 204/18639 0.127450980392157 1.16677741823645 0.229747031981349 0.771939679039959 GO:0060589 nucleoside-triphosphatase regulator activity 59/2036 490/18639 0.120408163265306 1.10230243374364 0.230024807600937 0.771939679039959 GO:0005109 frizzled binding 6/2036 38/18639 0.157894736842105 1.44548133595285 0.230337946316847 0.771939679039959 GO:0005501 retinoid binding 6/2036 38/18639 0.157894736842105 1.44548133595285 0.230337946316847 0.771939679039959 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/2036 38/18639 0.157894736842105 1.44548133595285 0.230337946316847 0.771939679039959 GO:0019840 isoprenoid binding 6/2036 38/18639 0.157894736842105 1.44548133595285 0.230337946316847 0.771939679039959 GO:0033218 amide binding 31/2036 247/18639 0.125506072874494 1.14897234396252 0.23109337759175 0.771939679039959 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/2036 128/18639 0.1328125 1.21586060289784 0.231453674529423 0.771939679039959 GO:0015485 cholesterol binding 8/2036 54/18639 0.148148148148148 1.3562540929928 0.232926656174906 0.772572159874895 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 8/2036 54/18639 0.148148148148148 1.3562540929928 0.232926656174906 0.772572159874895 GO:0004867 serine-type endopeptidase inhibitor activity 13/2036 95/18639 0.136842105263158 1.25275049115914 0.235140440828963 0.776042640575264 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0008171 O-methyltransferase activity 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0017134 fibroblast growth factor binding 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0044013 histone H2B acetyltransferase activity 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0140102 catalytic activity, acting on a rRNA 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0140103 catalytic activity, acting on a glycoprotein 4/2036 23/18639 0.173913043478261 1.59212437003502 0.238484864628611 0.776042640575264 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/2036 39/18639 0.153846153846154 1.40841771195406 0.249098683321161 0.793329168318651 GO:0003688 DNA replication origin binding 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0005024 transforming growth factor beta receptor activity 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0005159 insulin-like growth factor receptor binding 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0005521 lamin binding 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0015923 mannosidase activity 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0016722 oxidoreductase activity, acting on metal ions 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0043023 ribosomal large subunit binding 3/2036 16/18639 0.1875 1.71650908644401 0.251045193629075 0.793329168318651 GO:0000049 tRNA binding 11/2036 80/18639 0.1375 1.25877333005894 0.254434926768067 0.801936261331814 GO:0140101 catalytic activity, acting on a tRNA 18/2036 139/18639 0.129496402877698 1.18550267840737 0.256781779973622 0.802384549249629 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0030215 semaphorin receptor binding 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0043998 histone H2A acetyltransferase activity 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0070840 dynein complex binding 4/2036 24/18639 0.166666666666667 1.5257858546169 0.263436529836969 0.802384549249629 GO:0022884 macromolecule transmembrane transporter activity 5/2036 32/18639 0.15625 1.43042423870334 0.267688970527579 0.802384549249629 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/2036 32/18639 0.15625 1.43042423870334 0.267688970527579 0.802384549249629 GO:0004532 RNA exonuclease activity 6/2036 40/18639 0.15 1.37320726915521 0.268269700200191 0.802384549249629 GO:0030331 nuclear estrogen receptor binding 6/2036 40/18639 0.15 1.37320726915521 0.268269700200191 0.802384549249629 GO:0017124 SH3 domain binding 15/2036 115/18639 0.130434782608696 1.19409327752627 0.272037888042287 0.802384549249629 GO:0004521 RNA endonuclease activity 10/2036 73/18639 0.136986301369863 1.25407056543854 0.272181335975543 0.802384549249629 GO:0015932 nucleobase-containing compound transmembrane transporter activity 8/2036 57/18639 0.140350877192982 1.28487229862475 0.280795689364403 0.802384549249629 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0017110 nucleoside diphosphate phosphatase activity 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0031489 myosin V binding 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0032183 SUMO binding 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0038191 neuropilin binding 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0046965 nuclear retinoid X receptor binding 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0070403 NAD+ binding 3/2036 17/18639 0.176470588235294 1.61553796371201 0.28202586195809 0.802384549249629 GO:0005004 GPI-linked ephrin receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0005008 hepatocyte growth factor receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0005009 insulin receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0005011 macrophage colony-stimulating factor receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0005020 stem cell factor receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0008288 boss receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0016763 pentosyltransferase activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0036332 placental growth factor receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0038062 protein tyrosine kinase collagen receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0060175 brain-derived neurotrophic factor receptor activity 7/2036 49/18639 0.142857142857143 1.30781644681448 0.284637437329987 0.802384549249629 GO:0035064 methylated histone binding 10/2036 74/18639 0.135135135135135 1.23712366590559 0.286509351056446 0.802384549249629 GO:0004812 aminoacyl-tRNA ligase activity 6/2036 41/18639 0.146341463414634 1.33971440893191 0.287788081598185 0.802384549249629 GO:0016875 ligase activity, forming carbon-oxygen bonds 6/2036 41/18639 0.146341463414634 1.33971440893191 0.287788081598185 0.802384549249629 GO:0000030 mannosyltransferase activity 4/2036 25/18639 0.16 1.46475442043222 0.288839912003438 0.802384549249629 GO:0008139 nuclear localization sequence binding 4/2036 25/18639 0.16 1.46475442043222 0.288839912003438 0.802384549249629 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2036 33/18639 0.151515151515152 1.38707804965172 0.289630576667105 0.802384549249629 GO:0071889 14-3-3 protein binding 5/2036 33/18639 0.151515151515152 1.38707804965172 0.289630576667105 0.802384549249629 GO:0005085 guanyl-nucleotide exchange factor activity 28/2036 230/18639 0.121739130434783 1.11448705902452 0.299643918815027 0.802384549249629 GO:0001094 TFIID-class transcription factor complex binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0004090 carbonyl reductase (NADPH) activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0004382 GDP phosphatase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0005337 nucleoside transmembrane transporter activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0005345 purine nucleobase transmembrane transporter activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0005381 iron ion transmembrane transporter activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0015643 toxic substance binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0031434 mitogen-activated protein kinase kinase binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0031720 haptoglobin binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0035374 chondroitin sulfate binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0043121 neurotrophin binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0043208 glycosphingolipid binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0043295 glutathione binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0070513 death domain binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0099122 RNA polymerase II C-terminal domain binding 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0140940 histone H2A methyltransferase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0140999 histone H3K4 trimethyltransferase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:1990259 histone H2AQ104 methyltransferase activity 2/2036 10/18639 0.2 1.83094302554028 0.299801235036703 0.802384549249629 GO:0061630 ubiquitin protein ligase activity 42/2036 353/18639 0.118980169971671 1.08922956193614 0.30065550430997 0.802384549249629 GO:0005007 fibroblast growth factor receptor activity 7/2036 50/18639 0.14 1.28166011787819 0.302601542116394 0.802384549249629 GO:0005017 platelet-derived growth factor receptor activity 7/2036 50/18639 0.14 1.28166011787819 0.302601542116394 0.802384549249629 GO:0005019 platelet-derived growth factor beta-receptor activity 7/2036 50/18639 0.14 1.28166011787819 0.302601542116394 0.802384549249629 GO:0015605 organophosphate ester transmembrane transporter activity 7/2036 50/18639 0.14 1.28166011787819 0.302601542116394 0.802384549249629 GO:0042054 histone methyltransferase activity 9/2036 67/18639 0.134328358208955 1.22973785297481 0.307441522655124 0.802384549249629 GO:0008307 structural constituent of muscle 6/2036 42/18639 0.142857142857143 1.30781644681448 0.307590990906057 0.802384549249629 GO:0043175 RNA polymerase core enzyme binding 6/2036 42/18639 0.142857142857143 1.30781644681448 0.307590990906057 0.802384549249629 GO:0051117 ATPase binding 11/2036 84/18639 0.130952380952381 1.19883174291328 0.308694851649546 0.802384549249629 GO:0061659 ubiquitin-like protein ligase activity 44/2036 372/18639 0.118279569892473 1.08281576779264 0.309563861421773 0.802384549249629 GO:0000400 four-way junction DNA binding 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:0070628 proteasome binding 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:1990381 ubiquitin-specific protease binding 3/2036 18/18639 0.166666666666667 1.5257858546169 0.313304103527097 0.802384549249629 GO:0045309 protein phosphorylated amino acid binding 8/2036 59/18639 0.135593220338983 1.24131730545103 0.314034817276332 0.802384549249629 GO:0070063 RNA polymerase binding 8/2036 59/18639 0.135593220338983 1.24131730545103 0.314034817276332 0.802384549249629 GO:0030247 polysaccharide binding 4/2036 26/18639 0.153846153846154 1.40841771195406 0.314556069141051 0.802384549249629 GO:0030507 spectrin binding 4/2036 26/18639 0.153846153846154 1.40841771195406 0.314556069141051 0.802384549249629 GO:0070006 metalloaminopeptidase activity 4/2036 26/18639 0.153846153846154 1.40841771195406 0.314556069141051 0.802384549249629 GO:0070412 R-SMAD binding 4/2036 26/18639 0.153846153846154 1.40841771195406 0.314556069141051 0.802384549249629 GO:0120014 phospholipid transfer activity 4/2036 26/18639 0.153846153846154 1.40841771195406 0.314556069141051 0.802384549249629 GO:0140034 methylation-dependent protein binding 10/2036 76/18639 0.131578947368421 1.20456777996071 0.315752304515289 0.803556924620832 GO:0016758 hexosyltransferase activity 24/2036 197/18639 0.121827411167513 1.11529524398392 0.316350483613185 0.803556924620832 GO:0008194 UDP-glycosyltransferase activity 18/2036 145/18639 0.124137931034483 1.13644739516293 0.318719407334773 0.807869824065404 GO:0005021 vascular endothelial growth factor receptor activity 7/2036 51/18639 0.137254901960784 1.25652952733156 0.320787124453876 0.80888703793721 GO:0005030 neurotrophin receptor activity 7/2036 51/18639 0.137254901960784 1.25652952733156 0.320787124453876 0.80888703793721 GO:0140223 general transcription initiation factor activity 9/2036 68/18639 0.132352941176471 1.21165347278401 0.323156696394502 0.80888703793721 GO:0048156 tau protein binding 6/2036 43/18639 0.13953488372093 1.27740211084205 0.32761622243446 0.80888703793721 GO:0016410 N-acyltransferase activity 12/2036 94/18639 0.127659574468085 1.1686870375789 0.328600932181297 0.80888703793721 GO:0042562 hormone binding 12/2036 94/18639 0.127659574468085 1.1686870375789 0.328600932181297 0.80888703793721 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/2036 60/18639 0.133333333333333 1.22062868369352 0.330942985007 0.80888703793721 GO:0004722 protein serine/threonine phosphatase activity 13/2036 103/18639 0.12621359223301 1.15544948213707 0.333675020430805 0.80888703793721 GO:0034061 DNA polymerase activity 5/2036 35/18639 0.142857142857143 1.30781644681448 0.334329545465407 0.80888703793721 GO:0015631 tubulin binding 45/2036 385/18639 0.116883116883117 1.07003163830276 0.336938950828376 0.80888703793721 GO:0005200 structural constituent of cytoskeleton 14/2036 112/18639 0.125 1.14433939096267 0.338084924329712 0.80888703793721 GO:0016279 protein-lysine N-methyltransferase activity 9/2036 69/18639 0.130434782608696 1.19409327752627 0.339023230897589 0.80888703793721 GO:0004364 glutathione transferase activity 4/2036 27/18639 0.148148148148148 1.3562540929928 0.340452858526141 0.80888703793721 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2036 27/18639 0.148148148148148 1.3562540929928 0.340452858526141 0.80888703793721 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0003953 NAD+ nucleosidase activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0005536 D-glucose binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0008199 ferric iron binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0008432 JUN kinase binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0015205 nucleobase transmembrane transporter activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0032050 clathrin heavy chain binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0034511 U3 snoRNA binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0035252 UDP-xylosyltransferase activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0042285 xylosyltransferase activity 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:1900750 oligopeptide binding 2/2036 11/18639 0.181818181818182 1.66449365958207 0.34194298155024 0.80888703793721 GO:0051082 unfolded protein binding 15/2036 121/18639 0.12396694214876 1.13488204062414 0.341951810024388 0.80888703793721 GO:0008276 protein methyltransferase activity 12/2036 95/18639 0.126315789473684 1.15638506876228 0.342113292376815 0.80888703793721 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0008301 DNA binding, bending 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0015245 fatty acid transmembrane transporter activity 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0016918 retinal binding 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0050145 nucleoside monophosphate kinase activity 3/2036 19/18639 0.157894736842105 1.44548133595285 0.344650374137698 0.80888703793721 GO:0001046 core promoter sequence-specific DNA binding 6/2036 44/18639 0.136363636363636 1.24837024468655 0.347802699119429 0.811988161676224 GO:0030547 signaling receptor inhibitor activity 6/2036 44/18639 0.136363636363636 1.24837024468655 0.347802699119429 0.811988161676224 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 8/2036 61/18639 0.131147540983607 1.20061837740346 0.347994926432667 0.811988161676224 GO:0016278 lysine N-methyltransferase activity 9/2036 70/18639 0.128571428571429 1.17703480213303 0.355011582936958 0.821747058813644 GO:0106310 protein serine kinase activity 42/2036 361/18639 0.116343490304709 1.0650915107021 0.355423394280941 0.821747058813644 GO:0000993 RNA polymerase II complex binding 5/2036 36/18639 0.138888888888889 1.27148821218075 0.356915650839115 0.821747058813644 GO:0005003 ephrin receptor activity 7/2036 53/18639 0.132075471698113 1.20911331875301 0.357637424267732 0.821747058813644 GO:0005005 transmembrane-ephrin receptor activity 7/2036 53/18639 0.132075471698113 1.20911331875301 0.357637424267732 0.821747058813644 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/2036 53/18639 0.132075471698113 1.20911331875301 0.357637424267732 0.821747058813644 GO:0017046 peptide hormone binding 7/2036 53/18639 0.132075471698113 1.20911331875301 0.357637424267732 0.821747058813644 GO:0038064 collagen receptor activity 7/2036 53/18639 0.132075471698113 1.20911331875301 0.357637424267732 0.821747058813644 GO:0008237 metallopeptidase activity 22/2036 184/18639 0.119565217391304 1.09458550439908 0.35958579093651 0.824650080547729 GO:0045499 chemorepellent activity 4/2036 28/18639 0.142857142857143 1.30781644681448 0.366405999725657 0.832883903992417 GO:0051019 mitogen-activated protein kinase binding 4/2036 28/18639 0.142857142857143 1.30781644681448 0.366405999725657 0.832883903992417 GO:0051537 2 iron, 2 sulfur cluster binding 4/2036 28/18639 0.142857142857143 1.30781644681448 0.366405999725657 0.832883903992417 GO:0051959 dynein light intermediate chain binding 4/2036 28/18639 0.142857142857143 1.30781644681448 0.366405999725657 0.832883903992417 GO:0051539 4 iron, 4 sulfur cluster binding 6/2036 45/18639 0.133333333333333 1.22062868369352 0.36809091472275 0.832883903992417 GO:0035402 histone H3T11 kinase activity 29/2036 247/18639 0.117408906882591 1.07484509596494 0.368675199249956 0.832883903992417 GO:0019842 vitamin binding 18/2036 150/18639 0.12 1.09856581532416 0.373094838683045 0.832883903992417 GO:0016408 C-acyltransferase activity 3/2036 20/18639 0.15 1.37320726915521 0.375859293142383 0.832883903992417 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/2036 20/18639 0.15 1.37320726915521 0.375859293142383 0.832883903992417 GO:0052745 inositol phosphate phosphatase activity 3/2036 20/18639 0.15 1.37320726915521 0.375859293142383 0.832883903992417 GO:0140939 histone H4 methyltransferase activity 3/2036 20/18639 0.15 1.37320726915521 0.375859293142383 0.832883903992417 GO:0050661 NADP binding 7/2036 54/18639 0.12962962962963 1.1867223313687 0.376211368451771 0.832883903992417 GO:0042805 actinin binding 5/2036 37/18639 0.135135135135135 1.23712366590559 0.379550927704929 0.832883903992417 GO:0043394 proteoglycan binding 5/2036 37/18639 0.135135135135135 1.23712366590559 0.379550927704929 0.832883903992417 GO:0000340 RNA 7-methylguanosine cap binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0003720 telomerase activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0004000 adenosine deaminase activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0004300 enoyl-CoA hydratase activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0005078 MAP-kinase scaffold activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0005095 GTPase inhibitor activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0008179 adenylate cyclase binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0008504 monoamine transmembrane transporter activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0017166 vinculin binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0035497 cAMP response element binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:1990459 transferrin receptor binding 2/2036 12/18639 0.166666666666667 1.5257858546169 0.38323727808289 0.832883903992417 GO:0030276 clathrin binding 6/2036 46/18639 0.130434782608696 1.19409327752627 0.388423320534307 0.84111812576134 GO:0030291 protein serine/threonine kinase inhibitor activity 6/2036 46/18639 0.130434782608696 1.19409327752627 0.388423320534307 0.84111812576134 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2036 29/18639 0.137931034482759 1.26271932795881 0.392299846552823 0.844953515652235 GO:0051861 glycolipid binding 4/2036 29/18639 0.137931034482759 1.26271932795881 0.392299846552823 0.844953515652235 GO:0097472 cyclin-dependent protein kinase activity 4/2036 29/18639 0.137931034482759 1.26271932795881 0.392299846552823 0.844953515652235 GO:0043531 ADP binding 5/2036 38/18639 0.131578947368421 1.20456777996071 0.402158955187971 0.847741083047962 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0005123 death receptor binding 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0008373 sialyltransferase activity 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0035613 RNA stem-loop binding 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0051010 microtubule plus-end binding 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0061891 calcium ion sensor activity 3/2036 21/18639 0.142857142857143 1.30781644681448 0.406749550442973 0.847741083047962 GO:0001784 phosphotyrosine residue binding 6/2036 47/18639 0.127659574468085 1.1686870375789 0.408744657469416 0.847741083047962 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 28/2036 243/18639 0.11522633744856 1.05486429454995 0.411718050327881 0.847741083047962 GO:0120013 lipid transfer activity 8/2036 65/18639 0.123076923076923 1.12673416956325 0.41692935053584 0.847741083047962 GO:0016769 transferase activity, transferring nitrogenous groups 4/2036 30/18639 0.133333333333333 1.22062868369352 0.418027903404645 0.847741083047962 GO:0031624 ubiquitin conjugating enzyme binding 4/2036 30/18639 0.133333333333333 1.22062868369352 0.418027903404645 0.847741083047962 GO:0070566 adenylyltransferase activity 4/2036 30/18639 0.133333333333333 1.22062868369352 0.418027903404645 0.847741083047962 GO:0048029 monosaccharide binding 9/2036 74/18639 0.121621621621622 1.11341129931503 0.419603784400964 0.847741083047962 GO:0003964 RNA-directed DNA polymerase activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0008417 fucosyltransferase activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0019855 calcium channel inhibitor activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0035325 Toll-like receptor binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0035673 oligopeptide transmembrane transporter activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0039706 co-receptor binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0043560 insulin receptor substrate binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0045159 myosin II binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0051011 microtubule minus-end binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0070123 transforming growth factor beta receptor activity, type III 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0071837 HMG box domain binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0097157 pre-mRNA intronic binding 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0140333 glycerophospholipid flippase activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0140666 annealing activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0140852 histone ubiquitin ligase activity 2/2036 13/18639 0.153846153846154 1.40841771195406 0.423366490069376 0.847741083047962 GO:0000217 DNA secondary structure binding 5/2036 39/18639 0.128205128205128 1.17368142662838 0.424667818697796 0.847741083047962 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2036 48/18639 0.125 1.14433939096267 0.429002235189743 0.847741083047962 GO:0140693 molecular condensate scaffold activity 6/2036 48/18639 0.125 1.14433939096267 0.429002235189743 0.847741083047962 GO:0004676 3-phosphoinositide-dependent protein kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0004711 ribosomal protein S6 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0035175 histone H3S10 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0035979 histone H2AXS139 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0044022 histone H3S28 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0044023 histone H4S1 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0044024 histone H2AS1 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0044025 histone H2BS14 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0072354 histone H3T3 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0072371 histone H2AS121 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0072518 Rho-dependent protein serine/threonine kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0140823 histone H2BS36 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0140855 histone H3S57 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0140995 histone H2A kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0140997 histone H4 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0140998 histone H2B kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:1990244 histone H2AT120 kinase activity 28/2036 245/18639 0.114285714285714 1.04625315745159 0.429503372640579 0.847741083047962 GO:0016887 ATP hydrolysis activity 47/2036 417/18639 0.112709832134293 1.03182640528049 0.432479200081924 0.852217605398751 GO:0008235 metalloexopeptidase activity 8/2036 66/18639 0.121212121212121 1.10966243972138 0.434173765248193 0.854126733420054 GO:0044183 protein folding chaperone 9/2036 75/18639 0.12 1.09856581532416 0.435771419530496 0.854126733420054 GO:0004527 exonuclease activity 10/2036 84/18639 0.119047619047619 1.08984703901207 0.436966783152395 0.854126733420054 GO:0016881 acid-amino acid ligase activity 3/2036 22/18639 0.136363636363636 1.24837024468655 0.437163279273408 0.854126733420054 GO:0140784 metal ion sensor activity 3/2036 22/18639 0.136363636363636 1.24837024468655 0.437163279273408 0.854126733420054 GO:0004677 DNA-dependent protein kinase activity 28/2036 246/18639 0.113821138211382 1.04200009583593 0.43841388808438 0.854126733420054 GO:0140857 histone H3T45 kinase activity 28/2036 246/18639 0.113821138211382 1.04200009583593 0.43841388808438 0.854126733420054 GO:0016411 acylglycerol O-acyltransferase activity 4/2036 31/18639 0.129032258064516 1.18125356486469 0.443493120261042 0.862626359926163 GO:0004177 aminopeptidase activity 5/2036 40/18639 0.125 1.14433939096267 0.447010407054597 0.864503404740086 GO:0061791 GTPase motor activity 5/2036 40/18639 0.125 1.14433939096267 0.447010407054597 0.864503404740086 GO:1990606 membrane scission GTPase motor activity 5/2036 40/18639 0.125 1.14433939096267 0.447010407054597 0.864503404740086 GO:0035403 histone H3T6 kinase activity 28/2036 247/18639 0.11336032388664 1.03778147196615 0.447330250127138 0.864503404740086 GO:0016500 protein-hormone receptor activity 8/2036 67/18639 0.119402985074627 1.09310031375539 0.451357798142168 0.869279708194531 GO:0098631 cell adhesion mediator activity 9/2036 76/18639 0.118421052631579 1.08411100196464 0.451893390204181 0.869279708194531 GO:0016798 hydrolase activity, acting on glycosyl bonds 15/2036 130/18639 0.115384615384615 1.05631328396554 0.451967688812107 0.869279708194531 GO:0004679 AMP-activated protein kinase activity 28/2036 248/18639 0.112903225806452 1.03359686925661 0.45624795196885 0.870302066539207 GO:0005344 oxygen carrier activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0008174 mRNA methyltransferase activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0008195 phosphatidate phosphatase activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0008494 translation activator activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0032454 histone H3K9 demethylase activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0042043 neurexin family protein binding 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0044548 S100 protein binding 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0061665 SUMO ligase activity 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0070742 C2H2 zinc finger domain binding 2/2036 14/18639 0.142857142857143 1.30781644681448 0.462092422049032 0.870302066539207 GO:0031072 heat shock protein binding 15/2036 131/18639 0.114503816793893 1.0482498237826 0.464246967046918 0.870302066539207 GO:0003887 DNA-directed DNA polymerase activity 3/2036 23/18639 0.130434782608696 1.19409327752627 0.466965041470128 0.870302066539207 GO:0070577 lysine-acetylated histone binding 3/2036 23/18639 0.130434782608696 1.19409327752627 0.466965041470128 0.870302066539207 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/2036 23/18639 0.130434782608696 1.19409327752627 0.466965041470128 0.870302066539207 GO:0005548 phospholipid transporter activity 8/2036 68/18639 0.117647058823529 1.07702530914134 0.46845127837519 0.870302066539207 GO:0030145 manganese ion binding 8/2036 68/18639 0.117647058823529 1.07702530914134 0.46845127837519 0.870302066539207 GO:0032934 sterol binding 8/2036 68/18639 0.117647058823529 1.07702530914134 0.46845127837519 0.870302066539207 GO:0017080 sodium channel regulator activity 5/2036 41/18639 0.121951219512195 1.11642867410992 0.469124618923543 0.870302066539207 GO:0042169 SH2 domain binding 5/2036 41/18639 0.121951219512195 1.11642867410992 0.469124618923543 0.870302066539207 GO:0042287 MHC protein binding 5/2036 41/18639 0.121951219512195 1.11642867410992 0.469124618923543 0.870302066539207 GO:0002039 p53 binding 8/2036 69/18639 0.115942028985507 1.06141624669001 0.485425448536187 0.89915729236549 GO:0004520 DNA endonuclease activity 5/2036 42/18639 0.119047619047619 1.08984703901207 0.490953487574555 0.906607360490435 GO:0019894 kinesin binding 5/2036 42/18639 0.119047619047619 1.08984703901207 0.490953487574555 0.906607360490435 GO:0019956 chemokine binding 4/2036 33/18639 0.121212121212121 1.10966243972138 0.493294539777469 0.909535414842377 GO:0140033 acetylation-dependent protein binding 3/2036 24/18639 0.125 1.14433939096267 0.496040543132007 0.910739834452971 GO:0004197 cysteine-type endopeptidase activity 10/2036 88/18639 0.113636363636364 1.04030853723879 0.497488101663725 0.910739834452971 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2036 15/18639 0.133333333333333 1.22062868369352 0.499242766394486 0.910739834452971 GO:0015929 hexosaminidase activity 2/2036 15/18639 0.133333333333333 1.22062868369352 0.499242766394486 0.910739834452971 GO:0016846 carbon-sulfur lyase activity 2/2036 15/18639 0.133333333333333 1.22062868369352 0.499242766394486 0.910739834452971 GO:0047372 monoacylglycerol lipase activity 2/2036 15/18639 0.133333333333333 1.22062868369352 0.499242766394486 0.910739834452971 GO:0120283 protein serine/threonine kinase binding 2/2036 15/18639 0.133333333333333 1.22062868369352 0.499242766394486 0.910739834452971 GO:0051087 protein-folding chaperone binding 15/2036 134/18639 0.111940298507463 1.02478154414568 0.500848992622655 0.912287726350494 GO:0141003 histone H2AX kinase activity 39/2036 354/18639 0.110169491525424 1.00857031067896 0.502940420231488 0.914713392686875 GO:0015026 coreceptor activity 7/2036 61/18639 0.114754098360656 1.05054108022803 0.505112896115624 0.9172789244694 GO:0005080 protein kinase C binding 6/2036 52/18639 0.115384615384615 1.05631328396554 0.50844252093483 0.92054856421885 GO:0030159 signaling receptor complex adaptor activity 6/2036 52/18639 0.115384615384615 1.05631328396554 0.50844252093483 0.92054856421885 GO:0008175 tRNA methyltransferase activity 4/2036 34/18639 0.117647058823529 1.07702530914134 0.517484059463528 0.926299673747643 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/2036 34/18639 0.117647058823529 1.07702530914134 0.517484059463528 0.926299673747643 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/2036 34/18639 0.117647058823529 1.07702530914134 0.517484059463528 0.926299673747643 GO:0090482 vitamin transmembrane transporter activity 4/2036 34/18639 0.117647058823529 1.07702530914134 0.517484059463528 0.926299673747643 GO:0005496 steroid binding 12/2036 108/18639 0.111111111111111 1.0171905697446 0.520649954439676 0.926299673747643 GO:0008483 transaminase activity 3/2036 25/18639 0.12 1.09856581532416 0.524295174649539 0.926299673747643 GO:0015271 outward rectifier potassium channel activity 3/2036 25/18639 0.12 1.09856581532416 0.524295174649539 0.926299673747643 GO:0047617 fatty acyl-CoA hydrolase activity 3/2036 25/18639 0.12 1.09856581532416 0.524295174649539 0.926299673747643 GO:0140996 histone H3 kinase activity 39/2036 357/18639 0.109243697478992 1.00009492991696 0.525350136770883 0.926299673747643 GO:0019210 kinase inhibitor activity 10/2036 90/18639 0.111111111111111 1.0171905697446 0.527131852640832 0.926299673747643 GO:0033192 calmodulin-dependent protein phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0140791 histone H2AXS140 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:1990439 MAP kinase serine/threonine phosphatase activity 9/2036 81/18639 0.111111111111111 1.0171905697446 0.530973551584588 0.926299673747643 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0004708 MAP kinase kinase activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0005149 interleukin-1 receptor binding 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0008296 3'-5'-DNA exonuclease activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0015562 efflux transmembrane transporter activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0019841 retinol binding 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0022841 potassium ion leak channel activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0030275 LRR domain binding 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0140327 flippase activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:0140328 floppase activity 2/2036 16/18639 0.125 1.14433939096267 0.53469956250383 0.926299673747643 GO:1901682 sulfur compound transmembrane transporter activity 7/2036 63/18639 0.111111111111111 1.0171905697446 0.540493174990117 0.934454868536537 GO:0061631 ubiquitin conjugating enzyme activity 4/2036 35/18639 0.114285714285714 1.04625315745159 0.541116899979415 0.934454868536537 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/2036 91/18639 0.10989010989011 1.00601265139576 0.541735463653242 0.934454868536537 GO:0005525 GTP binding 41/2036 378/18639 0.108465608465608 0.99297174665544 0.544201660385649 0.937365950077714 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 9/2036 82/18639 0.109756097560976 1.00478580669893 0.546330331562384 0.937768178903448 GO:0033549 MAP kinase phosphatase activity 9/2036 82/18639 0.109756097560976 1.00478580669893 0.546330331562384 0.937768178903448 GO:0004721 phosphoprotein phosphatase activity 19/2036 175/18639 0.108571428571429 0.993940499579006 0.547398551223578 0.937768178903448 GO:0035173 histone kinase activity 39/2036 360/18639 0.108333333333333 0.991760805500982 0.547550689177013 0.937768178903448 GO:0016289 acyl-CoA hydrolase activity 3/2036 26/18639 0.115384615384615 1.05631328396554 0.551652449281081 0.939447735409366 GO:0043548 phosphatidylinositol 3-kinase binding 3/2036 26/18639 0.115384615384615 1.05631328396554 0.551652449281081 0.939447735409366 GO:0050681 nuclear androgen receptor binding 3/2036 26/18639 0.115384615384615 1.05631328396554 0.551652449281081 0.939447735409366 GO:0097602 cullin family protein binding 3/2036 26/18639 0.115384615384615 1.05631328396554 0.551652449281081 0.939447735409366 GO:0019209 kinase activator activity 16/2036 148/18639 0.108108108108108 0.989698932724473 0.556817544282751 0.946529494673427 GO:0004536 DNA nuclease activity 7/2036 64/18639 0.109375 1.00129696709234 0.5577889631855 0.946529494673427 GO:0030295 protein kinase activator activity 15/2036 139/18639 0.107913669064748 0.98791889867281 0.560440351584627 0.946529494673427 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/2036 83/18639 0.108433734939759 0.992679953606173 0.561488522751767 0.946529494673427 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/2036 36/18639 0.111111111111111 1.0171905697446 0.564142056121951 0.946529494673427 GO:0008238 exopeptidase activity 11/2036 102/18639 0.107843137254902 0.987273200046227 0.565131276465347 0.946529494673427 GO:0008374 O-acyltransferase activity 6/2036 55/18639 0.109090909090909 0.998696195749241 0.565217814820274 0.946529494673427 GO:0004550 nucleoside diphosphate kinase activity 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0008429 phosphatidylethanolamine binding 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0015278 intracellularly gated calcium channel activity 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0016018 cyclosporin A binding 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0016805 dipeptidase activity 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0048038 quinone binding 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0070402 NADPH binding 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0070492 oligosaccharide binding 2/2036 17/18639 0.117647058823529 1.07702530914134 0.568389389243262 0.946529494673427 GO:0004713 protein tyrosine kinase activity 15/2036 140/18639 0.107142857142857 0.980862335110862 0.57206070374525 0.951327468659228 GO:0004860 protein kinase inhibitor activity 9/2036 84/18639 0.107142857142857 0.980862335110862 0.576431131503691 0.955954658857362 GO:0017018 myosin phosphatase activity 9/2036 84/18639 0.107142857142857 0.980862335110862 0.576431131503691 0.955954658857362 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2036 27/18639 0.111111111111111 1.0171905697446 0.578052398125449 0.956739220297497 GO:0005319 lipid transporter activity 19/2036 178/18639 0.106741573033708 0.977188693406327 0.578493482040347 0.956739220297497 GO:0003725 double-stranded RNA binding 8/2036 75/18639 0.106666666666667 0.976502946954813 0.583349458774225 0.9634468427492 GO:0005516 calmodulin binding 22/2036 207/18639 0.106280193236715 0.97296489279918 0.58776014806332 0.969401668860599 GO:0005504 fatty acid binding 5/2036 47/18639 0.106382978723404 0.973905864649082 0.594184778087989 0.978657281556688 GO:0008308 voltage-gated monoatomic anion channel activity 2/2036 18/18639 0.111111111111111 1.0171905697446 0.600275049957783 0.983307700883225 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/2036 18/18639 0.111111111111111 1.0171905697446 0.600275049957783 0.983307700883225 GO:0017075 syntaxin-1 binding 2/2036 18/18639 0.111111111111111 1.0171905697446 0.600275049957783 0.983307700883225 GO:0032393 MHC class I receptor activity 2/2036 18/18639 0.111111111111111 1.0171905697446 0.600275049957783 0.983307700883225 GO:0046875 ephrin receptor binding 3/2036 28/18639 0.107142857142857 0.980862335110862 0.603449965933424 0.98582599590752 GO:0141052 histone H3 demethylase activity 3/2036 28/18639 0.107142857142857 0.980862335110862 0.603449965933424 0.98582599590752 GO:0051015 actin filament binding 22/2036 209/18639 0.105263157894737 0.963654223968566 0.606482851340812 0.989438147715904 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/2036 67/18639 0.104477611940299 0.956462774535965 0.607819165755616 0.989567419912619 GO:0042887 amide transmembrane transporter activity 4/2036 38/18639 0.105263157894737 0.963654223968566 0.608205889315065 0.989567419912619 GO:0101005 deubiquitinase activity 12/2036 115/18639 0.104347826086957 0.955274622021013 0.611302479487706 0.993263407966529 GO:0036121 double-stranded DNA helicase activity 5/2036 48/18639 0.104166666666667 0.95361615913556 0.613392050518018 0.995315402727349 GO:0106222 lncRNA binding 3/2036 29/18639 0.103448275862069 0.947039495969108 0.62781344124657 0.998771699699006 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0008574 plus-end-directed microtubule motor activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0022840 leak channel activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0022842 narrow pore channel activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0034987 immunoglobulin receptor binding 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0042577 lipid phosphatase activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0046527 glucosyltransferase activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0046624 sphingolipid transporter activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0140036 ubiquitin-modified protein reader activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0141147 intracellularly calcium-gated channel activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:1990380 K48-linked deubiquitinase activity 2/2036 19/18639 0.105263157894737 0.963654223968566 0.630348541230734 0.998771699699006 GO:0019001 guanyl nucleotide binding 42/2036 400/18639 0.105 0.961245088408644 0.632137153077852 0.998771699699006 GO:0032561 guanyl ribonucleotide binding 42/2036 400/18639 0.105 0.961245088408644 0.632137153077852 0.998771699699006 GO:0044325 transmembrane transporter binding 14/2036 136/18639 0.102941176470588 0.942397145498671 0.634095224784929 0.998771699699006 GO:0140789 histone phosphatase activity 14/2036 136/18639 0.102941176470588 0.942397145498671 0.634095224784929 0.998771699699006 GO:0001786 phosphatidylserine binding 6/2036 59/18639 0.101694915254237 0.930987979088275 0.635595417563295 0.998771699699006 GO:0016835 carbon-oxygen lyase activity 8/2036 79/18639 0.10126582278481 0.927059759767228 0.643403799012578 0.998771699699006 GO:0033293 monocarboxylic acid binding 8/2036 79/18639 0.10126582278481 0.927059759767228 0.643403799012578 0.998771699699006 GO:0015036 disulfide oxidoreductase activity 4/2036 40/18639 0.1 0.915471512770138 0.649422920120802 0.998771699699006 GO:0032451 demethylase activity 4/2036 40/18639 0.1 0.915471512770138 0.649422920120802 0.998771699699006 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/2036 40/18639 0.1 0.915471512770138 0.649422920120802 0.998771699699006 GO:0050997 quaternary ammonium group binding 4/2036 40/18639 0.1 0.915471512770138 0.649422920120802 0.998771699699006 GO:0071949 FAD binding 4/2036 40/18639 0.1 0.915471512770138 0.649422920120802 0.998771699699006 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2036 30/18639 0.1 0.915471512770138 0.651122945451229 0.998771699699006 GO:0032452 histone demethylase activity 3/2036 30/18639 0.1 0.915471512770138 0.651122945451229 0.998771699699006 GO:0048019 receptor antagonist activity 3/2036 30/18639 0.1 0.915471512770138 0.651122945451229 0.998771699699006 GO:0001972 retinoic acid binding 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0005326 neurotransmitter transmembrane transporter activity 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0015095 magnesium ion transmembrane transporter activity 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0016004 phospholipase activator activity 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0016505 peptidase activator activity involved in apoptotic process 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0042288 MHC class I protein binding 2/2036 20/18639 0.1 0.915471512770138 0.658625124351662 0.998771699699006 GO:0031406 carboxylic acid binding 19/2036 187/18639 0.101604278074866 0.930158221531156 0.666211539112482 0.998771699699006 GO:0004222 metalloendopeptidase activity 11/2036 110/18639 0.1 0.915471512770138 0.667335847553346 0.998771699699006 GO:0016836 hydro-lyase activity 6/2036 61/18639 0.0983606557377049 0.900463783052594 0.668131408986048 0.998771699699006 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/2036 41/18639 0.0975609756097561 0.893142939287939 0.668914628358343 0.998771699699006 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/2036 41/18639 0.0975609756097561 0.893142939287939 0.668914628358343 0.998771699699006 GO:0001618 virus receptor activity 8/2036 81/18639 0.0987654320987654 0.904169395328531 0.671501718659505 0.998771699699006 GO:0008327 methyl-CpG binding 3/2036 31/18639 0.0967741935483871 0.88594017364852 0.673368998150177 0.998771699699006 GO:0016878 acid-thiol ligase activity 3/2036 31/18639 0.0967741935483871 0.88594017364852 0.673368998150177 0.998771699699006 GO:0140457 protein demethylase activity 3/2036 31/18639 0.0967741935483871 0.88594017364852 0.673368998150177 0.998771699699006 GO:0072341 modified amino acid binding 9/2036 91/18639 0.0989010989010989 0.90541138625618 0.673833592357083 0.998771699699006 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 13/2036 130/18639 0.1 0.915471512770138 0.673982974044016 0.998771699699006 GO:0046982 protein heterodimerization activity 38/2036 369/18639 0.102981029810298 0.942761991470602 0.676003492824879 0.998771699699006 GO:0043177 organic acid binding 19/2036 189/18639 0.100529100529101 0.920315277387969 0.684334500580315 0.998771699699006 GO:0140272 exogenous protein binding 8/2036 82/18639 0.0975609756097561 0.893142939287939 0.685033760507842 0.998771699699006 GO:0005248 voltage-gated sodium channel activity 2/2036 21/18639 0.0952380952380952 0.871877631209655 0.68513834265784 0.998771699699006 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/2036 21/18639 0.0952380952380952 0.871877631209655 0.68513834265784 0.998771699699006 GO:0019200 carbohydrate kinase activity 2/2036 21/18639 0.0952380952380952 0.871877631209655 0.68513834265784 0.998771699699006 GO:0036122 BMP binding 2/2036 21/18639 0.0952380952380952 0.871877631209655 0.68513834265784 0.998771699699006 GO:0070182 DNA polymerase binding 2/2036 21/18639 0.0952380952380952 0.871877631209655 0.68513834265784 0.998771699699006 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0004935 adrenergic receptor activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0004955 prostaglandin receptor activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0005131 growth hormone receptor binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0005522 profilin binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0005528 FK506 binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0008140 cAMP response element binding protein binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0008190 eukaryotic initiation factor 4E binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0008239 dipeptidyl-peptidase activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0015203 polyamine transmembrane transporter activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0015279 store-operated calcium channel activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0019531 oxalate transmembrane transporter activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0030957 Tat protein binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0031419 cobalamin binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0031996 thioesterase binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0032356 oxidized DNA binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0045322 unmethylated CpG binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0047429 nucleoside triphosphate diphosphatase activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0050815 phosphoserine residue binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0051864 histone H3K36 demethylase activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0070097 delta-catenin binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0141109 transporter activator activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:1990757 ubiquitin ligase activator activity 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:1990763 arrestin family protein binding 1/2036 10/18639 0.1 0.915471512770138 0.685579414791337 0.998771699699006 GO:0022804 active transmembrane transporter activity 47/2036 457/18639 0.102844638949672 0.941513371995546 0.693322357581343 0.998771699699006 GO:0120015 sterol transfer activity 3/2036 32/18639 0.09375 0.858254543222004 0.694551170497327 0.998771699699006 GO:0043539 protein serine/threonine kinase activator activity 7/2036 73/18639 0.0958904109589041 0.877849395806981 0.698016466245685 0.998771699699006 GO:0030165 PDZ domain binding 8/2036 83/18639 0.0963855421686747 0.882382180983265 0.698211919201823 0.998771699699006 GO:0140296 general transcription initiation factor binding 5/2036 53/18639 0.0943396226415094 0.863652370537866 0.700974673928017 0.998771699699006 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/2036 43/18639 0.0930232558139535 0.851601407228035 0.705616830997443 0.998771699699006 GO:0008093 cytoskeletal anchor activity 2/2036 22/18639 0.0909090909090909 0.832246829791034 0.709935848996283 0.998771699699006 GO:0050321 tau-protein kinase activity 2/2036 22/18639 0.0909090909090909 0.832246829791034 0.709935848996283 0.998771699699006 GO:0019239 deaminase activity 3/2036 33/18639 0.0909090909090909 0.832246829791034 0.714676833569313 0.998771699699006 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/2036 54/18639 0.0925925925925926 0.847658808120498 0.716724171903135 0.998771699699006 GO:0005506 iron ion binding 15/2036 154/18639 0.0974025974025974 0.891693031918965 0.719231553993229 0.998771699699006 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0002162 dystroglycan binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0004954 prostanoid receptor activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0005114 type II transforming growth factor beta receptor binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0005225 volume-sensitive anion channel activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0008046 axon guidance receptor activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0008526 phosphatidylinositol transfer activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0010854 adenylate cyclase regulator activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0015217 ADP transmembrane transporter activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0032794 GTPase activating protein binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0034713 type I transforming growth factor beta receptor binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0043522 leucine zipper domain binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0045294 alpha-catenin binding 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0047676 arachidonate-CoA ligase activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0097493 structural molecule activity conferring elasticity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0180030 inositol phosphate kinase activity 1/2036 11/18639 0.0909090909090909 0.832246829791034 0.719943058115446 0.998771699699006 GO:0043014 alpha-tubulin binding 4/2036 44/18639 0.0909090909090909 0.832246829791034 0.722823189082154 0.998771699699006 GO:0005096 GTPase activator activity 27/2036 271/18639 0.0996309963099631 0.912093389106779 0.723298387694882 0.998771699699006 GO:0035401 histone H3Y41 kinase activity 11/2036 115/18639 0.0956521739130435 0.875668403519262 0.723620626340323 0.998771699699006 GO:0140801 histone H2AXY142 kinase activity 11/2036 115/18639 0.0956521739130435 0.875668403519262 0.723620626340323 0.998771699699006 GO:0038024 cargo receptor activity 6/2036 65/18639 0.0923076923076923 0.845050627172435 0.727436381251978 0.998771699699006 GO:0098632 cell-cell adhesion mediator activity 5/2036 55/18639 0.0909090909090909 0.832246829791034 0.731874807611421 0.998771699699006 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0005158 insulin receptor binding 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0005212 structural constituent of eye lens 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0031681 G-protein beta-subunit binding 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0043274 phospholipase binding 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0099186 structural constituent of postsynapse 2/2036 23/18639 0.0869565217391304 0.796062185017511 0.733075925903536 0.998771699699006 GO:0015020 glucuronosyltransferase activity 3/2036 34/18639 0.0882352941176471 0.807768981856004 0.733760005256969 0.998771699699006 GO:0015035 protein-disulfide reductase activity 3/2036 34/18639 0.0882352941176471 0.807768981856004 0.733760005256969 0.998771699699006 GO:0030332 cyclin binding 3/2036 34/18639 0.0882352941176471 0.807768981856004 0.733760005256969 0.998771699699006 GO:0004896 cytokine receptor activity 9/2036 96/18639 0.09375 0.858254543222004 0.73446187361005 0.998771699699006 GO:0016791 phosphatase activity 27/2036 273/18639 0.0989010989010989 0.90541138625618 0.737137428780404 0.998771699699006 GO:0046915 transition metal ion transmembrane transporter activity 4/2036 45/18639 0.0888888888888889 0.813752455795678 0.739270715619069 0.998771699699006 GO:0019783 ubiquitin-like protein peptidase activity 12/2036 127/18639 0.094488188976378 0.865012453011154 0.744370609209266 0.998771699699006 GO:0030170 pyridoxal phosphate binding 5/2036 56/18639 0.0892857142857143 0.817385279259051 0.746428087692493 0.998771699699006 GO:0170055 lipid transmembrane transporter activity 5/2036 56/18639 0.0892857142857143 0.817385279259051 0.746428087692493 0.998771699699006 GO:0008081 phosphoric diester hydrolase activity 8/2036 87/18639 0.0919540229885057 0.841812885305874 0.747299801291419 0.998771699699006 GO:0008234 cysteine-type peptidase activity 18/2036 187/18639 0.0962566844919786 0.881202525661095 0.749693547676371 0.998771699699006 GO:0004126 cytidine deaminase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005025 transforming growth factor beta receptor activity, type I 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005026 transforming growth factor beta receptor activity, type II 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005165 neurotrophin receptor binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005247 voltage-gated chloride channel activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005527 macrolide binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0010853 cyclase activator activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0015132 prostaglandin transmembrane transporter activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0016208 AMP binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0016361 activin receptor activity, type I 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0016362 activin receptor activity, type II 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0016423 tRNA (guanine) methyltransferase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0016840 carbon-nitrogen lyase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0017002 activin receptor activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0034452 dynactin binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0035251 UDP-glucosyltransferase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0035259 nuclear glucocorticoid receptor binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0045295 gamma-catenin binding 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:1990817 poly(A) RNA polymerase activity 1/2036 12/18639 0.0833333333333333 0.762892927308448 0.750552674482042 0.998771699699006 GO:0005154 epidermal growth factor receptor binding 3/2036 35/18639 0.0857142857142857 0.784689868088689 0.751820296376741 0.998771699699006 GO:0004622 lysophospholipase activity 2/2036 24/18639 0.0833333333333333 0.762892927308448 0.754624597064584 0.998771699699006 GO:0005540 hyaluronic acid binding 2/2036 24/18639 0.0833333333333333 0.762892927308448 0.754624597064584 0.998771699699006 GO:0035035 histone acetyltransferase binding 2/2036 24/18639 0.0833333333333333 0.762892927308448 0.754624597064584 0.998771699699006 GO:0060229 lipase activator activity 2/2036 24/18639 0.0833333333333333 0.762892927308448 0.754624597064584 0.998771699699006 GO:0004843 cysteine-type deubiquitinase activity 10/2036 108/18639 0.0925925925925926 0.847658808120498 0.75505655651854 0.998771699699006 GO:0070279 vitamin B6 binding 5/2036 57/18639 0.087719298245614 0.803045186640472 0.760387920652423 0.998771699699006 GO:0140767 enzyme-substrate adaptor activity 13/2036 139/18639 0.0935251798561151 0.856196378849769 0.762981455893202 0.998771699699006 GO:0004033 aldo-keto reductase (NADPH) activity 3/2036 36/18639 0.0833333333333333 0.762892927308448 0.768881954581721 0.998771699699006 GO:0003727 single-stranded RNA binding 8/2036 89/18639 0.0898876404494382 0.822895741815854 0.769642314789099 0.998771699699006 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/2036 89/18639 0.0898876404494382 0.822895741815854 0.769642314789099 0.998771699699006 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/2036 89/18639 0.0898876404494382 0.822895741815854 0.769642314789099 0.998771699699006 GO:0061749 forked DNA-dependent helicase activity 4/2036 47/18639 0.0851063829787234 0.779124691719266 0.769923758904471 0.998771699699006 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/2036 47/18639 0.0851063829787234 0.779124691719266 0.769923758904471 0.998771699699006 GO:0017116 single-stranded DNA helicase activity 5/2036 58/18639 0.0862068965517241 0.789199579974256 0.773760370896652 0.998771699699006 GO:0015645 fatty acid ligase activity 2/2036 25/18639 0.08 0.73237721021611 0.774653242491979 0.998771699699006 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/2036 25/18639 0.08 0.73237721021611 0.774653242491979 0.998771699699006 GO:0120020 cholesterol transfer activity 2/2036 25/18639 0.08 0.73237721021611 0.774653242491979 0.998771699699006 GO:0120515 fatty acid-CoA ligase activity 2/2036 25/18639 0.08 0.73237721021611 0.774653242491979 0.998771699699006 GO:0004175 endopeptidase activity 40/2036 405/18639 0.0987654320987654 0.904169395328531 0.774867296995801 0.998771699699006 GO:0005172 vascular endothelial growth factor receptor binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0005542 folic acid binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0008035 high-density lipoprotein particle binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0009982 pseudouridine synthase activity 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0031432 titin binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0032396 inhibitory MHC class I receptor activity 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0046975 histone H3K36 methyltransferase activity 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0061459 L-arginine transmembrane transporter activity 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0070700 BMP receptor binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0071714 icosanoid transmembrane transporter activity 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:1901338 catecholamine binding 1/2036 13/18639 0.0769230769230769 0.704208855977029 0.777818189849765 0.998771699699006 GO:0140793 histone H2AXY142 phosphatase activity 8/2036 90/18639 0.0888888888888889 0.813752455795678 0.780264107230426 0.998771699699006 GO:0009378 four-way junction helicase activity 4/2036 48/18639 0.0833333333333333 0.762892927308448 0.78415391421233 0.998771699699006 GO:0032266 phosphatidylinositol-3-phosphate binding 4/2036 48/18639 0.0833333333333333 0.762892927308448 0.78415391421233 0.998771699699006 GO:0043138 3'-5' DNA helicase activity 4/2036 48/18639 0.0833333333333333 0.762892927308448 0.78415391421233 0.998771699699006 GO:0022829 wide pore channel activity 3/2036 37/18639 0.0810810810810811 0.742274199543355 0.784973003072374 0.998771699699006 GO:0015459 potassium channel regulator activity 5/2036 59/18639 0.0847457627118644 0.775823315906896 0.786553422131222 0.998771699699006 GO:0036002 pre-mRNA binding 5/2036 59/18639 0.0847457627118644 0.775823315906896 0.786553422131222 0.998771699699006 GO:0070888 E-box binding 5/2036 59/18639 0.0847457627118644 0.775823315906896 0.786553422131222 0.998771699699006 GO:0008083 growth factor activity 15/2036 162/18639 0.0925925925925926 0.847658808120498 0.787391746630295 0.998771699699006 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 11/2036 122/18639 0.0901639344262295 0.825425134464878 0.791387604268204 0.998771699699006 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0004529 DNA exonuclease activity 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0005160 transforming growth factor beta receptor binding 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0005227 calcium-activated cation channel activity 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0008198 ferrous iron binding 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0015216 purine nucleotide transmembrane transporter activity 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0019865 immunoglobulin binding 2/2036 26/18639 0.0769230769230769 0.704208855977029 0.79323664192622 0.998771699699006 GO:0003823 antigen binding 16/2036 174/18639 0.0919540229885057 0.841812885305874 0.801865586837328 0.998771699699006 GO:0004065 arylsulfatase activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0005161 platelet-derived growth factor receptor binding 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0005347 ATP transmembrane transporter activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0008474 palmitoyl-(protein) hydrolase activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0015926 glucosidase activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0019992 diacylglycerol binding 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0030983 mismatched DNA binding 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0034236 protein kinase A catalytic subunit binding 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0098599 palmitoyl hydrolase activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0098821 BMP receptor activity 1/2036 14/18639 0.0714285714285714 0.653908223407241 0.802104787372898 0.998771699699006 GO:0005125 cytokine activity 22/2036 234/18639 0.094017094017094 0.860699712860813 0.802214674698289 0.998771699699006 GO:0042578 phosphoric ester hydrolase activity 35/2036 363/18639 0.0964187327823691 0.882686031596551 0.808040115210765 0.998771699699006 GO:0005126 cytokine receptor binding 26/2036 275/18639 0.0945454545454545 0.865536702982675 0.810313017271974 0.998771699699006 GO:0001671 ATPase activator activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0005044 scavenger receptor activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0005385 zinc ion transmembrane transporter activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0016405 CoA-ligase activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/2036 27/18639 0.0740740740740741 0.678127046496398 0.810451381430282 0.998771699699006 GO:0048020 CCR chemokine receptor binding 4/2036 50/18639 0.08 0.73237721021611 0.81050103269982 0.998771699699006 GO:0140375 immune receptor activity 14/2036 156/18639 0.0897435897435897 0.821576998639867 0.818023922541873 0.998771699699006 GO:0005272 sodium channel activity 4/2036 51/18639 0.0784313725490196 0.718016872760892 0.822655452252415 0.998771699699006 GO:0016830 carbon-carbon lyase activity 4/2036 51/18639 0.0784313725490196 0.718016872760892 0.822655452252415 0.998771699699006 GO:0030544 Hsp70 protein binding 4/2036 51/18639 0.0784313725490196 0.718016872760892 0.822655452252415 0.998771699699006 GO:0000774 adenyl-nucleotide exchange factor activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0004953 icosanoid receptor activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0008242 omega peptidase activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0015116 sulfate transmembrane transporter activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0017081 chloride channel regulator activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0031005 filamin binding 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0061578 K63-linked deubiquitinase activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0140776 protein-containing complex destabilizing activity 1/2036 15/18639 0.0666666666666667 0.610314341846758 0.823737788871356 0.998771699699006 GO:0097718 disordered domain specific binding 2/2036 28/18639 0.0714285714285714 0.653908223407241 0.826374567237733 0.999999999999999 GO:0003678 DNA helicase activity 6/2036 74/18639 0.0810810810810811 0.742274199543355 0.832418997771086 0.999999999999999 GO:0001530 lipopolysaccharide binding 3/2036 41/18639 0.0731707317073171 0.669857204465954 0.840282909420651 0.999999999999999 GO:0004629 phospholipase C activity 2/2036 29/18639 0.0689655172413793 0.631359663979405 0.841082798792634 0.999999999999999 GO:0035250 UDP-galactosyltransferase activity 2/2036 29/18639 0.0689655172413793 0.631359663979405 0.841082798792634 0.999999999999999 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/2036 29/18639 0.0689655172413793 0.631359663979405 0.841082798792634 0.999999999999999 GO:0099604 ligand-gated calcium channel activity 2/2036 29/18639 0.0689655172413793 0.631359663979405 0.841082798792634 0.999999999999999 GO:0019003 GDP binding 6/2036 75/18639 0.08 0.73237721021611 0.84177301842241 0.999999999999999 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2036 16/18639 0.0625 0.572169695481336 0.843007003962524 0.999999999999999 GO:0008142 oxysterol binding 1/2036 16/18639 0.0625 0.572169695481336 0.843007003962524 0.999999999999999 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2036 16/18639 0.0625 0.572169695481336 0.843007003962524 0.999999999999999 GO:0055102 lipase inhibitor activity 1/2036 16/18639 0.0625 0.572169695481336 0.843007003962524 0.999999999999999 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2036 16/18639 0.0625 0.572169695481336 0.843007003962524 0.999999999999999 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 16/2036 181/18639 0.0883977900552486 0.809256585874155 0.847490246970048 0.999999999999999 GO:0004725 protein tyrosine phosphatase activity 8/2036 98/18639 0.0816326530612245 0.74732368389399 0.852509542648496 0.999999999999999 GO:0042626 ATPase-coupled transmembrane transporter activity 8/2036 98/18639 0.0816326530612245 0.74732368389399 0.852509542648496 0.999999999999999 GO:0001965 G-protein alpha-subunit binding 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0015215 nucleotide transmembrane transporter activity 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0022839 monoatomic ion-gated channel activity 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0031210 phosphatidylcholine binding 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0033612 receptor serine/threonine kinase binding 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0098918 structural constituent of synapse 2/2036 30/18639 0.0666666666666667 0.610314341846758 0.854651359745591 0.999999999999999 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0008484 sulfuric ester hydrolase activity 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0030169 low-density lipoprotein particle binding 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0030548 acetylcholine receptor regulator activity 1/2036 17/18639 0.0588235294117647 0.538512654570669 0.860170604882478 0.999999999999999 GO:0003774 cytoskeletal motor activity 13/2036 153/18639 0.0849673202614379 0.777851612157633 0.865587614388016 0.999999999999999 GO:0005452 solute:inorganic anion antiporter activity 2/2036 31/18639 0.0645161290322581 0.590626782432347 0.867153591579758 0.999999999999999 GO:0017147 Wnt-protein binding 2/2036 31/18639 0.0645161290322581 0.590626782432347 0.867153591579758 0.999999999999999 GO:0072349 modified amino acid transmembrane transporter activity 2/2036 31/18639 0.0645161290322581 0.590626782432347 0.867153591579758 0.999999999999999 GO:1902936 phosphatidylinositol bisphosphate binding 9/2036 111/18639 0.0810810810810811 0.742274199543355 0.868438239625124 0.999999999999999 GO:0000900 mRNA regulatory element binding translation repressor activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0008409 5'-3' exonuclease activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0008525 phosphatidylcholine transporter activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0015280 ligand-gated sodium channel activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0016854 racemase and epimerase activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0017128 phospholipid scramblase activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0030228 lipoprotein particle receptor activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0031690 adrenergic receptor binding 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0035615 clathrin adaptor activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0099602 neurotransmitter receptor regulator activity 1/2036 18/18639 0.0555555555555556 0.508595284872299 0.875458578701578 0.999999999999999 GO:0004252 serine-type endopeptidase activity 15/2036 176/18639 0.0852272727272727 0.780231402929094 0.876967204256726 0.999999999999999 GO:0008378 galactosyltransferase activity 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0015106 bicarbonate transmembrane transporter activity 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0042910 xenobiotic transmembrane transporter activity 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0043425 bHLH transcription factor binding 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0071813 lipoprotein particle binding 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0071814 protein-lipid complex binding 2/2036 32/18639 0.0625 0.572169695481336 0.87866041965192 0.999999999999999 GO:0140303 intramembrane lipid transporter activity 3/2036 45/18639 0.0666666666666667 0.610314341846758 0.882832623340446 0.999999999999999 GO:0015297 antiporter activity 11/2036 135/18639 0.0814814814814815 0.745939751146038 0.883738498667185 0.999999999999999 GO:0003756 protein disulfide isomerase activity 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0030506 ankyrin binding 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0042834 peptidoglycan binding 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0043395 heparan sulfate proteoglycan binding 1/2036 19/18639 0.0526315789473684 0.481827111984283 0.889075803005514 0.999999999999999 GO:0030296 protein tyrosine kinase activator activity 2/2036 33/18639 0.0606060606060606 0.55483121986069 0.889240005850798 0.999999999999999 GO:0016247 channel regulator activity 14/2036 168/18639 0.0833333333333333 0.762892927308448 0.889440291130448 0.999999999999999 GO:0004180 carboxypeptidase activity 3/2036 46/18639 0.0652173913043478 0.597046638763133 0.891753463348002 0.999999999999999 GO:0016829 lyase activity 17/2036 200/18639 0.085 0.778150785854617 0.891772974436294 0.999999999999999 GO:0016782 transferase activity, transferring sulphur-containing groups 5/2036 70/18639 0.0714285714285714 0.653908223407241 0.892622369526417 0.999999999999999 GO:0141108 transporter regulator activity 14/2036 170/18639 0.0823529411764706 0.753917716398937 0.898789031634063 0.999999999999999 GO:0016831 carboxy-lyase activity 2/2036 34/18639 0.0588235294117647 0.538512654570669 0.898957505887912 0.999999999999999 GO:0019825 oxygen binding 2/2036 34/18639 0.0588235294117647 0.538512654570669 0.898957505887912 0.999999999999999 GO:0051427 hormone receptor binding 2/2036 34/18639 0.0588235294117647 0.538512654570669 0.898957505887912 0.999999999999999 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2036 20/18639 0.05 0.457735756385069 0.901204786092558 0.999999999999999 GO:0010851 cyclase regulator activity 1/2036 20/18639 0.05 0.457735756385069 0.901204786092558 0.999999999999999 GO:0030627 pre-mRNA 5'-splice site binding 1/2036 20/18639 0.05 0.457735756385069 0.901204786092558 0.999999999999999 GO:0030742 GTP-dependent protein binding 1/2036 20/18639 0.05 0.457735756385069 0.901204786092558 0.999999999999999 GO:0099106 ion channel regulator activity 13/2036 160/18639 0.08125 0.743820604125737 0.901769282432835 0.999999999999999 GO:0005543 phospholipid binding 46/2036 497/18639 0.0925553319919517 0.847317697936143 0.902188595090761 0.999999999999999 GO:0005254 chloride channel activity 6/2036 83/18639 0.072289156626506 0.661786635737449 0.902215614669168 0.999999999999999 GO:0008013 beta-catenin binding 8/2036 106/18639 0.0754716981132075 0.690921896430292 0.904357881219345 0.999999999999999 GO:0042379 chemokine receptor binding 5/2036 72/18639 0.0694444444444444 0.635744106090373 0.90601370208243 0.999999999999999 GO:0140566 histone reader activity 2/2036 35/18639 0.0571428571428571 0.523126578725793 0.907874912524953 0.999999999999999 GO:0010314 phosphatidylinositol-5-phosphate binding 1/2036 21/18639 0.0476190476190476 0.435938815604827 0.912008108264294 0.999999999999999 GO:0015174 basic amino acid transmembrane transporter activity 1/2036 21/18639 0.0476190476190476 0.435938815604827 0.912008108264294 0.999999999999999 GO:0051428 peptide hormone receptor binding 1/2036 21/18639 0.0476190476190476 0.435938815604827 0.912008108264294 0.999999999999999 GO:0140312 cargo adaptor activity 1/2036 21/18639 0.0476190476190476 0.435938815604827 0.912008108264294 0.999999999999999 GO:1904047 S-adenosyl-L-methionine binding 1/2036 21/18639 0.0476190476190476 0.435938815604827 0.912008108264294 0.999999999999999 GO:0046906 tetrapyrrole binding 12/2036 152/18639 0.0789473684210526 0.722740667976424 0.913883882042003 0.999999999999999 GO:0060590 ATPase regulator activity 3/2036 49/18639 0.0612244897959184 0.560492762920492 0.914968418218457 0.999999999999999 GO:0004190 aspartic-type endopeptidase activity 2/2036 36/18639 0.0555555555555556 0.508595284872299 0.916050968874554 0.999999999999999 GO:0045505 dynein intermediate chain binding 2/2036 36/18639 0.0555555555555556 0.508595284872299 0.916050968874554 0.999999999999999 GO:0003924 GTPase activity 29/2036 331/18639 0.0876132930513595 0.802074739285015 0.916724294718665 0.999999999999999 GO:0020037 heme binding 11/2036 142/18639 0.0774647887323944 0.709168073272642 0.917694721445031 0.999999999999999 GO:0005243 gap junction channel activity 1/2036 22/18639 0.0454545454545455 0.416123414895517 0.921630596800866 0.999999999999999 GO:0015377 chloride:monoatomic cation symporter activity 1/2036 22/18639 0.0454545454545455 0.416123414895517 0.921630596800866 0.999999999999999 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/2036 22/18639 0.0454545454545455 0.416123414895517 0.921630596800866 0.999999999999999 GO:0031683 G-protein beta/gamma-subunit complex binding 1/2036 22/18639 0.0454545454545455 0.416123414895517 0.921630596800866 0.999999999999999 GO:0140517 protein-RNA adaptor activity 1/2036 22/18639 0.0454545454545455 0.416123414895517 0.921630596800866 0.999999999999999 GO:0030551 cyclic nucleotide binding 2/2036 37/18639 0.0540540540540541 0.494849466362237 0.923541138348965 0.999999999999999 GO:0070001 aspartic-type peptidase activity 2/2036 37/18639 0.0540540540540541 0.494849466362237 0.923541138348965 0.999999999999999 GO:0016597 amino acid binding 3/2036 51/18639 0.0588235294117647 0.538512654570669 0.927822867768796 0.999999999999999 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2036 23/18639 0.0434782608695652 0.398031092508755 0.930201263659836 0.999999999999999 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/2036 23/18639 0.0434782608695652 0.398031092508755 0.930201263659836 0.999999999999999 GO:0000146 microfilament motor activity 2/2036 38/18639 0.0526315789473684 0.481827111984283 0.930397619925804 0.999999999999999 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/2036 52/18639 0.0576923076923077 0.528156641982772 0.933557464690686 0.999999999999999 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0004806 triacylglycerol lipase activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0005315 phosphate transmembrane transporter activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0015149 hexose transmembrane transporter activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0015295 solute:proton symporter activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0030552 cAMP binding 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0055056 D-glucose transmembrane transporter activity 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0070300 phosphatidic acid binding 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/2036 24/18639 0.0416666666666667 0.381446463654224 0.937835031772673 0.999999999999999 GO:0005544 calcium-dependent phospholipid binding 3/2036 53/18639 0.0566037735849057 0.518191422322719 0.938869120048882 0.999999999999999 GO:0001217 DNA-binding transcription repressor activity 23/2036 278/18639 0.0827338129496403 0.757404488982488 0.940877008204945 0.999999999999999 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 22/2036 268/18639 0.082089552238806 0.751506465706829 0.94219336571073 0.999999999999999 GO:0005253 monoatomic anion channel activity 7/2036 103/18639 0.0679611650485437 0.622165105766113 0.942195194783561 0.999999999999999 GO:0015144 carbohydrate transmembrane transporter activity 2/2036 40/18639 0.05 0.457735756385069 0.942402327213195 0.999999999999999 GO:0140662 ATP-dependent protein folding chaperone 2/2036 40/18639 0.05 0.457735756385069 0.942402327213195 0.999999999999999 GO:0003925 G protein activity 3/2036 54/18639 0.0555555555555556 0.508595284872299 0.943785284071394 0.999999999999999 GO:0140463 chromatin-protein adaptor activity 3/2036 54/18639 0.0555555555555556 0.508595284872299 0.943785284071394 0.999999999999999 GO:0001848 complement binding 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0005537 D-mannose binding 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0015662 P-type ion transporter activity 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0017025 TBP-class protein binding 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0017056 structural constituent of nuclear pore 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0140358 P-type transmembrane transporter activity 1/2036 25/18639 0.04 0.366188605108055 0.944634272992702 0.999999999999999 GO:0008236 serine-type peptidase activity 15/2036 194/18639 0.077319587628866 0.707838798533612 0.945047028516343 0.999999999999999 GO:0070851 growth factor receptor binding 10/2036 139/18639 0.0719424460431655 0.658612599115207 0.946736762310438 0.999999999999999 GO:0001727 lipid kinase activity 2/2036 41/18639 0.0487804878048781 0.44657146964397 0.947639220433326 0.999999999999999 GO:0003777 microtubule motor activity 4/2036 68/18639 0.0588235294117647 0.538512654570669 0.94811729805764 0.999999999999999 GO:0015101 organic cation transmembrane transporter activity 5/2036 81/18639 0.0617283950617284 0.565105872080332 0.949759090466316 0.999999999999999 GO:1901981 phosphatidylinositol phosphate binding 14/2036 185/18639 0.0756756756756757 0.692789252907131 0.950104384724575 0.999999999999999 GO:0004435 phosphatidylinositol phospholipase C activity 1/2036 26/18639 0.0384615384615385 0.352104427988514 0.950690178235361 0.999999999999999 GO:0008143 poly(A) binding 1/2036 26/18639 0.0384615384615385 0.352104427988514 0.950690178235361 0.999999999999999 GO:0015145 monosaccharide transmembrane transporter activity 1/2036 26/18639 0.0384615384615385 0.352104427988514 0.950690178235361 0.999999999999999 GO:0052742 phosphatidylinositol kinase activity 1/2036 26/18639 0.0384615384615385 0.352104427988514 0.950690178235361 0.999999999999999 GO:0035198 miRNA binding 2/2036 42/18639 0.0476190476190476 0.435938815604827 0.952419976255495 0.999999999999999 GO:0017171 serine hydrolase activity 15/2036 198/18639 0.0757575757575758 0.693539024825862 0.954712607155455 0.999999999999999 GO:0008395 steroid hydroxylase activity 1/2036 27/18639 0.037037037037037 0.339063523248199 0.956083978112479 0.999999999999999 GO:0005262 calcium channel activity 9/2036 131/18639 0.0687022900763359 0.62894989426956 0.956446322556558 0.999999999999999 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 42/2036 484/18639 0.0867768595041322 0.794417428436896 0.956940051487665 0.999999999999999 GO:0001664 G protein-coupled receptor binding 24/2036 297/18639 0.0808080808080808 0.739774959814253 0.957954545287197 0.999999999999999 GO:0061980 regulatory RNA binding 3/2036 58/18639 0.0517241379310345 0.473519747984554 0.959997509614053 0.999999999999999 GO:0015108 chloride transmembrane transporter activity 8/2036 121/18639 0.0661157024793388 0.605270421666207 0.960829940268136 0.999999999999999 GO:0005242 inward rectifier potassium channel activity 1/2036 28/18639 0.0357142857142857 0.326954111703621 0.9608880303671 0.999999999999999 GO:0016866 intramolecular transferase activity 1/2036 28/18639 0.0357142857142857 0.326954111703621 0.9608880303671 0.999999999999999 GO:0051119 sugar transmembrane transporter activity 1/2036 28/18639 0.0357142857142857 0.326954111703621 0.9608880303671 0.999999999999999 GO:0008009 chemokine activity 2/2036 45/18639 0.0444444444444444 0.406876227897839 0.964383311197128 0.999999999999999 GO:0003785 actin monomer binding 1/2036 29/18639 0.0344827586206897 0.315679831989703 0.965166788637616 0.999999999999999 GO:0004181 metallocarboxypeptidase activity 1/2036 29/18639 0.0344827586206897 0.315679831989703 0.965166788637616 0.999999999999999 GO:0001216 DNA-binding transcription activator activity 42/2036 491/18639 0.0855397148676171 0.783091721717837 0.965895966990074 0.999999999999999 GO:0015085 calcium ion transmembrane transporter activity 10/2036 147/18639 0.0680272108843537 0.622769736578325 0.966343803844416 0.999999999999999 GO:0099095 ligand-gated monoatomic anion channel activity 2/2036 47/18639 0.0425531914893617 0.389562345859633 0.970690207198078 0.999999999999999 GO:0140359 ABC-type transporter activity 2/2036 47/18639 0.0425531914893617 0.389562345859633 0.970690207198078 0.999999999999999 GO:0015179 L-amino acid transmembrane transporter activity 3/2036 62/18639 0.0483870967741935 0.44297008682426 0.971737408610224 0.999999999999999 GO:0005184 neuropeptide hormone activity 1/2036 31/18639 0.032258064516129 0.295313391216173 0.972371801293169 0.999999999999999 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/2036 31/18639 0.032258064516129 0.295313391216173 0.972371801293169 0.999999999999999 GO:0070717 poly-purine tract binding 1/2036 32/18639 0.03125 0.286084847740668 0.975394749088048 0.999999999999999 GO:0160041 neuropeptide activity 1/2036 32/18639 0.03125 0.286084847740668 0.975394749088048 0.999999999999999 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2036 34/18639 0.0294117647058824 0.269256327285335 0.980484950842281 0.999999999999999 GO:0043015 gamma-tubulin binding 1/2036 35/18639 0.0285714285714286 0.261563289362896 0.982620540204556 0.999999999999999 GO:0004620 phospholipase activity 6/2036 109/18639 0.055045871559633 0.503929273084479 0.983550897255684 0.999999999999999 GO:0005246 calcium channel regulator activity 2/2036 53/18639 0.0377358490566038 0.345460948215146 0.983791354327354 0.999999999999999 GO:0008509 monoatomic anion transmembrane transporter activity 9/2036 149/18639 0.0604026845637584 0.552969370129613 0.985903806105308 0.999999999999999 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/2036 70/18639 0.0428571428571429 0.392344934044345 0.986152107484693 0.999999999999999 GO:0030280 structural constituent of skin epidermis 1/2036 37/18639 0.027027027027027 0.247424733181118 0.986216455445949 0.999999999999999 GO:0140299 molecular sensor activity 3/2036 71/18639 0.0422535211267606 0.386818949057805 0.987353260124649 0.999999999999999 GO:0008514 organic anion transmembrane transporter activity 19/2036 269/18639 0.0706319702602231 0.646615566640618 0.987877451117446 0.999999999999999 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/2036 86/18639 0.0465116279069767 0.425800703614017 0.987933849759514 0.999999999999999 GO:0071855 neuropeptide receptor binding 1/2036 40/18639 0.025 0.228867878192534 0.990265215174476 0.999999999999999 GO:0016298 lipase activity 7/2036 130/18639 0.0538461538461538 0.49294619918392 0.990872255160463 0.999999999999999 GO:0008227 G protein-coupled amine receptor activity 1/2036 41/18639 0.024390243902439 0.223285734821985 0.991330865043005 0.999999999999999 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/2036 41/18639 0.024390243902439 0.223285734821985 0.991330865043005 0.999999999999999 GO:0005179 hormone activity 7/2036 132/18639 0.053030303030303 0.485477317378103 0.992117849890878 0.999999999999999 GO:0004497 monooxygenase activity 5/2036 106/18639 0.0471698113207547 0.431826185268933 0.992661192000529 0.999999999999999 GO:0005245 voltage-gated calcium channel activity 1/2036 43/18639 0.0232558139534884 0.212900351807009 0.993125106625217 0.999999999999999 GO:0008528 G protein-coupled peptide receptor activity 6/2036 122/18639 0.0491803278688525 0.450231891526297 0.993874544414421 0.999999999999999 GO:0035091 phosphatidylinositol binding 19/2036 284/18639 0.0669014084507042 0.61246333600819 0.994536319630259 0.999999999999999 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/2036 45/18639 0.0222222222222222 0.203438113948919 0.994548140120664 0.999999999999999 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2036 46/18639 0.0217391304347826 0.199015546254378 0.995145106169622 0.999999999999999 GO:0015103 inorganic anion transmembrane transporter activity 9/2036 165/18639 0.0545454545454545 0.49934809787462 0.995254006376605 0.999999999999999 GO:0005249 voltage-gated potassium channel activity 4/2036 98/18639 0.0408163265306122 0.373661841946995 0.995716117641712 0.999999999999999 GO:0001653 peptide receptor activity 6/2036 128/18639 0.046875 0.429127271611002 0.996183343171857 0.999999999999999 GO:0035254 glutamate receptor binding 1/2036 49/18639 0.0204081632653061 0.186830920973497 0.996571788103406 0.999999999999999 GO:0015171 amino acid transmembrane transporter activity 4/2036 102/18639 0.0392156862745098 0.359008436380446 0.99699367605918 0.999999999999999 GO:0022832 voltage-gated channel activity 9/2036 175/18639 0.0514285714285714 0.470813920853214 0.997679070425252 0.999999999999999 GO:0003730 mRNA 3'-UTR binding 15/2036 262/18639 0.0572519083969466 0.5241249118913 0.998848610051686 0.999999999999999 GO:0005244 voltage-gated monoatomic ion channel activity 8/2036 173/18639 0.046242774566474 0.423339427870584 0.999023206376022 0.999999999999999 GO:0046943 carboxylic acid transmembrane transporter activity 9/2036 188/18639 0.0478723404255319 0.438257639092087 0.999115887568268 0.999999999999999 GO:0005342 organic acid transmembrane transporter activity 9/2036 189/18639 0.0476190476190476 0.435938815604827 0.999180398320406 0.999999999999999 GO:0099094 ligand-gated monoatomic cation channel activity 5/2036 136/18639 0.0367647058823529 0.336570409106668 0.999431136131172 0.999999999999999 GO:0015291 secondary active transmembrane transporter activity 16/2036 287/18639 0.0557491289198606 0.510367393878822 0.999488147491356 0.999999999999999 GO:0005267 potassium channel activity 4/2036 124/18639 0.032258064516129 0.295313391216173 0.999598175457911 0.999999999999999 GO:0005261 monoatomic cation channel activity 20/2036 341/18639 0.0586510263929619 0.536933438574861 0.999608442147351 0.999999999999999 GO:0022843 voltage-gated monoatomic cation channel activity 5/2036 143/18639 0.034965034965035 0.320094934535013 0.999695529442513 0.999999999999999 GO:0015294 solute:monoatomic cation symporter activity 3/2036 116/18639 0.0258620689655172 0.236759873992277 0.999833441960797 0.999999999999999 GO:0015370 solute:sodium symporter activity 1/2036 79/18639 0.0126582278481013 0.115882469970903 0.99989467700434 0.999999999999999 GO:0015079 potassium ion transmembrane transporter activity 5/2036 160/18639 0.03125 0.286084847740668 0.9999355842631 0.999999999999999 GO:0005216 monoatomic ion channel activity 26/2036 448/18639 0.0580357142857143 0.531300431518383 0.999949526863725 0.999999999999999 GO:0015293 symporter activity 4/2036 146/18639 0.0273972602739726 0.250814113087709 0.99995073728217 0.999999999999999 GO:0015081 sodium ion transmembrane transporter activity 5/2036 164/18639 0.0304878048780488 0.279107168527481 0.999955592561401 0.999999999999999 GO:0015276 ligand-gated monoatomic ion channel activity 6/2036 186/18639 0.032258064516129 0.295313391216173 0.999973755024698 0.999999999999999 GO:0022834 ligand-gated channel activity 6/2036 188/18639 0.0319148936170213 0.292171759394725 0.999978120221015 0.999999999999999 GO:0022836 gated channel activity 13/2036 318/18639 0.0408805031446541 0.374249360566408 0.999997237194147 0.999999999999999 GO:0046873 metal ion transmembrane transporter activity 20/2036 450/18639 0.0444444444444444 0.406876227897839 0.999999796189654 0.999999999999999 GO:0045182 translation regulator activity 9/2036 356/18639 0.0252808988764045 0.231439427385709 0.999999999630842 0.999999999999999 GO:0030371 translation repressor activity 2/2036 329/18639 0.0060790273556231 0.0556517636942333 0.999999999999999 0.999999999999999