category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	22/173	238/9376	5.00976344294943	RPL13A/RPS27/RPL37A/RPS8/RPS28/RPS20/RPS26/PLCG2/RPL36/RPS11/C1QB/RPL7/RPS15/RPL31/C1QA/RPL10/RPS17/RPL18A/RPL28/RPL23/FGG/RPL27A	8.59064222805726
Genetic Information Processing	Translation	hsa03010	Ribosome	19/173	222/9376	4.63844191011821	RPL13A/RPS27/RPL37A/RPS8/RPS28/RPS20/RPS26/RPL36/RPS11/RPL7/RPS15/RPL31/RPL10/RPS17/RPL18A/RPL28/RPL23/MRPS18A/RPL27A	7.52195026372008
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/173	138/9376	5.8909273686856	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/ATP5ME/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1	7.93570941125093
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/173	205/9376	4.49434653884111	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/CTSD/TGFBR1/MT-CO1/GAPDH	6.93551211794696
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/173	275/9376	3.54740935365213	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/C1QB/COX7A1/MT-ND4L/MT-ND6/C1QA/MT-CO1/CCL5/PSMC1	5.87847272662855
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/173	227/9376	3.82001986198467	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/GSTA1/MT-CO1/VEGFA	5.89687960108048
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/173	39/9376	9.72758262931673	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	7.48801269624843
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/173	235/9376	3.68997663264051	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/ATP5ME/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1/BMP8B	5.72571283480656
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/173	44/9376	8.62217551234892	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	6.94803338881744
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/173	45/9376	8.4305716120745	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	6.85028065708371
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/173	82/9376	5.94839983081912	CD74/HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/TAPBP/HLA-DPA1/HLA-G	6.17041471789203
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/173	268/9376	3.23561383832284	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1/PSMC1/UBA1	5.09092447235782
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/173	308/9376	2.9913670144884	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/AP2B1/MT-ND6/MT-CO1/PSMC1/POLR2I	4.87208537946898
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/173	54/9376	7.02547634339542	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	6.08804277383674
Human Diseases	Immune disease	hsa05310	Asthma	5/173	32/9376	8.46820809248555	HLA-DRA/PRG2/HLA-DRB5/HLA-DRB1/HLA-DPA1	5.8018829589441
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/173	70/9376	5.41965317919075	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	5.08861583687808
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/173	95/9376	4.56391846668695	FLT1/HLA-DRA/HLA-DRB5/HLA-DRB1/CCL5/ACP5/HLA-DPA1/VEGFA	4.78669939912832
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/173	99/9376	4.37951772055818	HLA-DRA/HLA-DRB5/C1QB/HLA-DRB1/C1QA/KRT18/HLA-DPA1/FGG	4.63460286500249
NA	NA	hsa04518	Integrin signaling	10/173	154/9376	3.51925531116283	FN1/FLT1/SPP1/KDR/LIMS2/FLNA/TLN1/VEGFA/ACTN4/FGG	4.32179301311979
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/173	388/9376	2.37459031047017	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1/IRS2/GAPDH/PSMC1	3.79141730429845
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/173	368/9376	2.35637094747424	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1/TNFRSF1B/PSMC1	3.6394200074316
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/173	205/9376	2.90810658395601	HLA-DRA/HLA-A/HLA-E/PLCG2/HLA-DRB5/NCOR2/HLA-DRB1/TAPBP/HLA-DPA1/HLA-G/PSMC1	3.78717342091384
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/173	180/9376	3.01091843288375	CD74/HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/CCL5/TAPBP/HLA-DPA1/HLA-G	3.73486755050846
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/173	155/9376	3.14689539436882	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/DYNC1I2/HLA-DRB1/HLA-DPA1/MRC2/HLA-G	3.69514683845812
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	10/173	203/9376	2.66977989122697	FN1/FLT1/SPP1/KDR/MYL9/PIP5K1C/FLNA/TLN1/VEGFA/ACTN4	3.2975814211838
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/173	87/9376	3.73769184771776	MT-CO2/MT-CYB/MT-CO3/COX7A1/MT-CO1/TPM1	3.51725362858069
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/173	88/9376	3.69521807672097	CLU/C1QB/SERPINE2/C1QA/FGG/CD59	3.48271649014349
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/173	66/9376	4.1057978630233	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/GATA3	3.4714770048878
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/173	480/9376	1.91946050096339	MT-CO2/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-CYB/MT-CO3/MT-ND4/MT-ND5/MT-ATP8/COX7A1/MT-ND4L/MT-ND6/MT-CO1/TNFRSF1B/PSMC1/UBA1	2.83530828851674
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/173	224/9376	2.41948802642444	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/TGFBR1/IL1R2/HLA-DPA1/TLN1/HLA-G	2.94809663958625
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/173	298/9376	2.18241067618419	TNFRSF11B/TGFBR1/TNFSF10/CXCL14/IL1R2/IL1RL1/CCL5/PRLR/PRL/BMP8B/CCL4/TNFRSF1B	2.84397231229444
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/173	100/9376	3.25179190751445	HLA-DRA/HLA-DRB5/HLA-DRB1/IL1R2/HLA-DPA1/CD59	3.10378666422584
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/173	233/9376	2.32603140737801	FN1/MYL9/TPM1/FBLN1/PLEC/SYNE2/TLN1/DSP/FBN2/SPTBN1	2.81016221443944
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/173	50/9376	4.3357225433526	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1	3.24243437781429
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/173	109/9376	2.98329532799491	HLA-DRA/HLA-DRB5/HLA-DRB1/TGFBR1/HLA-DPA1/GATA3	2.85545312391862
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/173	143/9376	2.65297708072275	HLA-DRA/HLA-DRB5/C1QB/HLA-DRB1/C1QA/HLA-DPA1/ACTN4	2.73091015016369
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/173	149/9376	2.54614578888156	MT-ND3/MT-ND1/MT-ND2/MT-ND4/MT-ND5/MT-ND4L/MT-ND6	2.60829851777466
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/173	60/9376	3.6131021194605	HSPB1/PLCG2/KDR/VEGFA	2.78394881515329
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/173	93/9376	2.91379203182299	IQGAP1/MYL9/TGFBR1/TCF7L2/ACTN4	2.54293945316955
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/173	93/9376	2.91379203182299	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/GATA3	2.54293945316955
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/173	160/9376	2.37109826589595	HLA-DRA/HLA-A/HLA-E/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-G	2.39828791257364
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/173	37/9376	4.39431338853304	HBB/APOA1/HBA2	2.83626359275316
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/173	133/9376	2.44495632143944	HLA-A/HLA-E/PLCG2/TNFSF10/TYROBP/HLA-G	2.30100754131899
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/173	100/9376	2.70982658959538	TNFSF10/CXCL14/CCL5/CCL4/TNFRSF1B	2.35676171906254
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/173	142/9376	2.28999430106651	PLCG2/TNFRSF11B/TGFBR1/ACP5/TYROBP/FOSB	2.12364054070621
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/173	181/9376	2.09599846709035	CD74/HLA-DRA/HLA-DRB5/CTSD/HLA-DRB1/HLA-DPA1/MRC2	2.04134940301712
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/173	110/9376	2.46347871781398	FLT1/PLCG2/ELOB/VEGFA/GAPDH	2.11680369348764
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/173	78/9376	2.77930932266192	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1	2.16345548387833
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/173	227/9376	1.91000993099234	HLA-A/HLA-E/AKAP13/CCL5/TAPBP/CCL4/VEGFA/HLA-G	1.90290113597736
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/173	157/9376	2.07120503663341	MT-CO2/MT-CYB/MT-CO3/COX7A1/MT-CO1/IRS2	1.85577151151991
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/173	204/9376	1.8596849144282	FN1/PLCG2/IQGAP1/KDR/TIMP3/FLNA/VEGFA	1.70202660858042
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/173	205/9376	1.85061328069928	HLA-A/HLA-E/YWHAE/CHD4/ACTN4/HLA-G/PSMC1	1.68828095622508
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/173	248/9376	1.74827521909379	AHNAK/DYNC1I2/AHNAK2/MYL9/TNFSF10/TCF7L2/FLNA/GAPDH	1.63735694494327
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	8/173	250/9376	1.73428901734104	HLA-A/HLA-E/RAB11FIP1/AP2B1/TGFBR1/PIP5K1C/EHD2/HLA-G	1.61339528507368
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/173	253/9376	1.71372432543581	CBX3/PLCG2/MYL9/CAPNS1/CCL5/CAST/TLN1/ACTN4	1.57785067775179
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/173	173/9376	1.87964850145344	HLA-DRA/HLA-DRB5/HLA-DRB1/TNFSF10/CCL5/HLA-DPA1	1.60107430028162
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/173	214/9376	1.77278375020258	HLA-A/HLA-E/PLCG2/ELOB/TAPBP/TNFRSF1B/HLA-G	1.5678831869914
NA	NA	hsa04382	Cornified envelope formation	7/173	217/9376	1.74827521909379	KRT8/KRT7/DST/KRT18/PLEC/DSP/COL17A1	1.52901300367213
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/173	101/9376	2.14639729868941	FN1/PLCG2/TGFBR1/VEGFA	1.58811833787125
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/173	103/9376	2.10471968123913	C1QB/C1QA/TGFBR1/CCL5	1.54562649047836
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/173	103/9376	2.10471968123913	FN1/HSPB1/IL1R2/ACTN4	1.54562649047836
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/173	36/9376	3.01091843288375	GALNT6/GALNT15	1.65735768367908
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/173	110/9376	1.97078297425118	EMP3/TGFBR1/BMP8B/LTBP1	1.40415911789913
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/173	112/9376	1.93559042113955	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1	1.36565023447452
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/173	196/9376	1.6590775038339	HLA-A/HLA-E/PLCG2/TCF7L2/VEGFA/HLA-G	1.27846005153714
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/173	333/9376	1.46477112951101	FN1/HLA-A/HLA-E/SPP1/CHD4/TCF7L2/VEGFA/HLA-G/PSMC1	1.18399255887306
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/173	116/9376	1.86884592385888	PLCG2/THY1/MYL9/ACTN4	1.29095245576156
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/173	250/9376	1.51750289017341	PSAP/AP2B1/CTSD/TPP1/CTSZ/CD68/ACP5	1.13706824329363
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/173	80/9376	2.03236994219653	PLCG2/KDR/VEGFA	1.27138260795728
Organismal Systems	Immune system	hsa04611	Platelet activation	4/173	126/9376	1.72052481879071	PLCG2/TLN1/RASGRP2/FGG	1.1163678730121
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/173	49/9376	2.2121033384452	GALNT6/GALNT15	1.16630107997309
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/173	50/9376	2.1678612716763	HBB/HBA2	1.13520039109586
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/173	15/9376	3.6131021194605	ST3GAL5	1.38862464212098
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/173	53/9376	2.04515214309085	AP2B1/ATP2B4	1.04612501443594
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/173	16/9376	3.38728323699422	MIF	1.31029774689875
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/173	142/9376	1.52666286737768	KDR/GSTA1/IL1R2/VEGFA	0.867013610465665
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/173	98/9376	1.6590775038339	PLCG2/PIP5K1C/MYO10	0.899220751636847
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/173	193/9376	1.40405522776962	PLCG2/CXCL14/CCL5/CCL4/RASGRP2	0.777626534315947
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/173	106/9376	1.53386410731814	ZEB1/IL1R2/TCF7L2	0.757857874893633
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/173	201/9376	1.34817243263452	FLT1/HPGD/ZEB1/NUPR1/IL1R2	0.684121678913575
NA	NA	hsa04517	IgSF CAM signaling	7/173	299/9376	1.26881512556305	PLCG2/IQGAP1/KDR/MYL9/ACTN4/FGG/SPTBN1	0.647682416643372
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/173	300/9376	1.26458574181118	FLT1/HSPB1/KDR/TGFBR1/FLNA/RASGRP2/VEGFA	0.638592479093753
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/173	21/9376	2.58078722818607	CHPF	0.994271861107208
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/173	63/9376	1.72052481879071	HPGD/PTGDS	0.786716750056775
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/173	109/9376	1.49164766399745	SPP1/CCL5/CCL4	0.707850635360558
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/173	157/9376	1.38080335775561	HLA-A/HLA-E/TGFBR1/HLA-G	0.659709391429815
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/173	157/9376	1.38080335775561	YWHAE/TGFBR1/TCF7L2/BMP8B	0.659709391429815
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/173	22/9376	2.46347871781398	AOC1	0.942199886527507
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/173	23/9376	2.35637094747424	PCYOX1	0.892916623851528
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/173	362/9376	1.19771340976591	FN1/FLT1/SPP1/YWHAE/KDR/PRLR/PRL/VEGFA	0.525987729897267
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/173	212/9376	1.27822008943178	FLT1/KDR/TLN1/RASGRP2/VEGFA	0.561769109827943
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/173	70/9376	1.54847233691164	IRS2/TNFRSF1B	0.631489600324057
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/173	70/9376	1.54847233691164	ELOB/VEGFA	0.631489600324057
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/173	71/9376	1.52666286737768	PRLR/PRL	0.610727763962538
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/173	71/9376	1.52666286737768	PLCG2/CCL5	0.610727763962538
NA	NA	hsa04081	Hormone signaling	5/173	219/9376	1.23736373954127	NPR3/TRH/IRS2/PRLR/PRL	0.487308295542272
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/173	170/9376	1.27521251275076	PLCG2/GSTA1/TGFBR1/TCF7L2	0.496479281472392
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/173	26/9376	2.08448199199644	APOA1	0.759184254401718
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/173	73/9376	1.48483648744952	MAP1B/SUPT5H	0.570150086462819
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/173	77/9376	1.40770212446513	TGFBR1/VEGFA	0.492509023662684
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/173	78/9376	1.38965466133096	PLCG2/PIP5K1C	0.473779630746866
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/173	78/9376	1.38965466133096	C1QB/C1QA	0.473779630746866
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/173	232/9376	1.1680287024118	FN1/IQGAP1/MYL9/PIP5K1C/ACTN4	0.355306650147442
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/173	31/9376	1.74827521909379	SEC62	0.572132390666277
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/173	184/9376	1.17818547373712	SEMA3B/PLCG2/DPYSL2/MYL9	0.334672616019515
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/173	133/9376	1.22247816071972	TGFBR1/TNFSF10/IRS2	0.354283321924141
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/173	238/9376	1.13858260067033	FLT1/PLCG2/KDR/RASGRP2/VEGFA	0.296903684801116
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/173	134/9376	1.21335518937106	CALD1/MYL9/ADM	0.341048863290155
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/173	83/9376	1.30594052510621	CCL5/CCL4	0.383832782317682
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/173	137/9376	1.186785367706	CTSD/TNFSF10/CTSZ	0.301949719477082
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/173	34/9376	1.59401564093846	POLR2I	0.475730927760697
NA	NA	hsa04519	Cadherin signaling	8/173	404/9376	1.0731986493447	YWHAE/KRT8/KDR/KRT7/KRT18/TCF7L2/DSP/ACTN4	0.206202105941329
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/173	86/9376	1.26038446027692	TCF7L2/DSP	0.332583277927827
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/173	87/9376	1.24589728257259	TGFBR1/TCF7L2	0.315916895507272
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/173	194/9376	1.11745426375067	DYNC1I2/MYL9/TPM1/MYO10	0.226644396629122
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/173	89/9376	1.21789959082938	FN1/SPP1	0.28317680278219
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/173	144/9376	1.12909441233141	C1QB/C1QA/TCF7L2	0.214034987547314
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/173	37/9376	1.46477112951101	MIF	0.388359377200748
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/173	37/9376	1.46477112951101	TCF7L2	0.388359377200748
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/173	254/9376	1.06686086204542	FLT1/PLCG2/KDR/ATP2B4/VEGFA	0.148111157096562
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/173	200/9376	1.08393063583815	NCL/TNFSF10/MYO10/GAPDH	0.16449503247008
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/173	38/9376	1.42622452083967	QPRT	0.360950188927153
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/173	93/9376	1.16551681272919	ATP2B4/LYZ	0.219929452235735
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/173	41/9376	1.32186662907091	VEGFA	0.28317486204739
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/173	98/9376	1.1060516692226	PLCG2/PIP5K1C	0.144692939989534
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/173	42/9376	1.29039361409304	AOC1	0.25859599081794
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/173	43/9376	1.26038446027692	APOA1	0.234629511085281
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/173	323/9376	1.00674672059271	PLCG2/ZEB1/IRS2/TPM1/TIMP3/VEGFA	0.016917715000931
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/173	157/9376	1.0356025183167	C1QB/MFGE8/C1QA	0.0616783313847656
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/173	44/9376	1.23173935890699	DYNC1I2	0.211243207478007
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/173	103/9376	1.05235984061956	UPF2/SRRM1	0.0732572779078644
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/173	46/9376	1.17818547373712	PSMC1	0.166094162358747
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/173	105/9376	1.03231489127443	PLCG2/CCL4	0.0456539161453905
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/173	47/9376	1.15311769770016	IRS2	0.144278211986709
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/173	166/9376	0.979455393829654	MYL9/ATP2B4/IRS2	-0.0366155892981557
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/173	108/9376	1.00363947762792	UPF2/SRRM1	0.00521557143425683
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/173	49/9376	1.1060516692226	FOSB	0.102044250208837
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/173	50/9376	1.08393063583815	AOC1	0.0815833977366457
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/173	170/9376	0.956409384563074	MYL9/SYNPO/ACTN4	-0.0786368221951579
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/173	51/9376	1.06267709395897	PLD3	0.0615337664210191
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/173	51/9376	1.06267709395897	PLCG2	0.0615337664210191
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/173	52/9376	1.04224099599822	APOA1	0.0418772995006131
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/173	174/9376	0.93442296192944	RRBP1/SEC62/SIL1	-0.119709684265088
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/173	115/9376	0.942548378989696	AKAP13/GATA3	-0.0849896897233784
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/173	117/9376	0.926436440887308	CHD4/BRD9	-0.109778577883137
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/173	55/9376	0.985391487125591	PSAP	-0.0148970431986743
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/173	119/9376	0.910866080536261	CCL5/TNFRSF1B	-0.134160704961332
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/173	120/9376	0.903275529865125	PLCG2/YWHAE	-0.146204011256895
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/173	122/9376	0.888467734293566	EEF2/IRS2	-0.170004207960586
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/173	122/9376	0.888467734293566	PLCG2/IRS2	-0.170004207960586
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/173	59/9376	0.918585284608602	GSTA1	-0.0860072072444867
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/173	59/9376	0.918585284608602	IRS2	-0.0860072072444867
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/173	59/9376	0.918585284608602	TCF7L2	-0.0860072072444867
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/173	125/9376	0.86714450867052	CTSD/NSMAF	-0.205014299973856
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/173	61/9376	0.888467734293566	ATP2B4	-0.119816875822073
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/173	62/9376	0.874137609546895	IRS2	-0.136322544135394
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/173	62/9376	0.874137609546895	NCOR2	-0.136322544135394
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/173	63/9376	0.860262409395357	POLR2I	-0.152574762553988
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/173	63/9376	0.860262409395357	TCF7L2	-0.152574762553988
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/173	130/9376	0.833792796798577	TGFBR1/VEGFA	-0.261630608902608
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/173	65/9376	0.833792796798577	SPP1	-0.184353902475747
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/173	67/9376	0.808903459580709	GAPDH	-0.215220031031796
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/173	68/9376	0.797007820469228	DHRS3	-0.230329494479563
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/173	68/9376	0.797007820469228	TCF7L2	-0.230329494479563
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/173	69/9376	0.785456982491413	PLCG2	-0.245232514812305
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/173	69/9376	0.785456982491413	FOSB	-0.245232514812305
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/173	138/9376	0.785456982491413	CPEB4/YWHAE	-0.348103930976716
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/173	138/9376	0.785456982491413	FN1/PIP5K1C	-0.348103930976716
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/173	70/9376	0.774236168455822	GSTA1	-0.259935646986747
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/173	139/9376	0.779806212833202	CTSD/KRT18	-0.358584050090634
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/173	140/9376	0.774236168455822	SPP1/TGFBR1	-0.368994932186806
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/173	71/9376	0.763331433688838	SLC16A3	-0.274445139873102
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/173	142/9376	0.763331433688838	ELOB/UBA1	-0.389613319774878
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/173	73/9376	0.74241824372476	GSTA1	-0.302906782829259
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/173	73/9376	0.74241824372476	PLCG2	-0.302906782829259
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/173	75/9376	0.7226204238921	GAPDH	-0.330661984891663
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/173	75/9376	0.7226204238921	GSTA1	-0.330661984891663
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/173	75/9376	0.7226204238921	CD82	-0.330661984891663
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/173	76/9376	0.713112260419836	APOA1	-0.344287527072947
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/173	76/9376	0.713112260419836	PLCG2	-0.344287527072947
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/173	77/9376	0.703851062232565	TGFBR1	-0.35775144510206
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/173	149/9376	0.727470225394732	PLCG2/PIP5K1C	-0.459749017372149
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/173	216/9376	0.752729608220938	APOA1/TNFSF10/CCL5	-0.504075087794017
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/173	78/9376	0.694827330665481	DHX36	-0.371058295818865
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/173	78/9376	0.694827330665481	FN1	-0.371058295818865
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/173	150/9376	0.7226204238921	TGFBR1/TCF7L2	-0.469523531749771
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/173	79/9376	0.686032047998829	GSTA1	-0.384212445949013
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/173	79/9376	0.686032047998829	AP2B1	-0.384212445949013
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/173	154/9376	0.703851062232565	DHRS3/QPRT	-0.508044740211495
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/173	154/9376	0.703851062232565	ATP2B4/TPM1	-0.508044740211495
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/173	154/9376	0.703851062232565	EEF2/MYL9	-0.508044740211495
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/173	82/9376	0.660933314535457	GSTA1	-0.422799720690912
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/173	83/9376	0.652970262553103	CBX3	-0.435383281194858
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/173	226/9376	0.719422988388153	FXYD1/MYL9/ATP2B4	-0.585382502054715
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/173	158/9376	0.686032047998829	YWHAE/ATRX	-0.545681826822061
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/173	86/9376	0.630192230138459	PLCG2	-0.472347236747265
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/173	90/9376	0.60218368657675	IRS2	-0.519916358610113
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/173	91/9376	0.595566283427555	PLCG2	-0.531521792380623
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/173	370/9376	0.732385564755507	NPW/TRH/PRLR/PRL/ADM	-0.720092695016142
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/173	168/9376	0.645196807046518	PRLR/PRL	-0.636214384094048
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/173	169/9376	0.641379074460444	CTSD/IRS2	-0.645006196008064
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/173	93/9376	0.582758406364597	FN1	-0.554407214742204
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/173	94/9376	0.57655884885008	FOSB	-0.565692192967855
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/173	98/9376	0.553025834611301	ATP2B4	-0.609834871657779
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/173	99/9376	0.547439715069773	PLCG2	-0.620632103913794
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/173	99/9376	0.547439715069773	PIP5K1C	-0.620632103913794
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/173	99/9376	0.547439715069773	TPM1	-0.620632103913794
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/173	178/9376	0.608949795414691	TCF7L2/NOTUM	-0.722170584467343
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/173	101/9376	0.536599324672352	TCF7L2	-0.641954679334208
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/173	102/9376	0.531338546979485	ATP2B4	-0.652483830229961
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/173	103/9376	0.526179920309782	COL17A1	-0.662927328377384
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/173	104/9376	0.521120497999111	PLD3	-0.673286931331841
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/173	105/9376	0.516157445637214	PLCG2	-0.68356434242221
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/173	105/9376	0.516157445637214	TPM1	-0.68356434242221
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/173	187/9376	0.579642051250348	YWHAE/CCL5	-0.79606754849661
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/173	109/9376	0.497215887999152	IRS2	-0.723884357011482
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/173	110/9376	0.492695743562796	CPEB4	-0.733774608866417
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/173	195/9376	0.555861864532385	PLCG2/FGG	-0.859279311831069
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/173	116/9376	0.46721148096472	GAPDH	-0.791630170738849
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/173	122/9376	0.444233867146783	PLCG2	-0.847132268214813
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/173	217/9376	0.499507205455369	GSTA1/VEGFA	-1.02269856274236
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/173	138/9376	0.392728491245707	IRS2	-0.985320341917305
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/173	144/9376	0.376364804110469	PSMC1	-1.03397001446986
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/173	148/9376	0.366192782377753	TCF7L2	-1.06556077251695
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/173	243/9376	0.446061990056852	RBM25/SYF2	-1.19950359295229
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/173	155/9376	0.349655043818758	TCF7L2	-1.11934662258978
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/173	156/9376	0.34741366533274	YWHAE	-1.12688291040978
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/173	163/9376	0.332494060073052	TGFBR1	-1.17867040777243
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/173	168/9376	0.322598403523259	TNFSF10	-1.21468083728119
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/173	191/9376	0.283751475350301	FOSB	-1.37114954050092