ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0031994 insulin-like growth factor I binding 6/114 13/18639 0.461538461538462 75.4615384615385 7.59514649844572e-11 2.17221189855548e-08 GO:0005520 insulin-like growth factor binding 6/114 19/18639 0.315789473684211 51.6315789473684 1.16554678502687e-09 1.66673190258842e-07 GO:0050840 extracellular matrix binding 8/114 67/18639 0.119402985074627 19.5223880597015 7.3786406374029e-09 7.0343040743241e-07 GO:0003735 structural constituent of ribosome 11/114 175/18639 0.0628571428571429 10.2771428571429 1.01621092790718e-08 7.26590813453634e-07 GO:0008191 metalloendopeptidase inhibitor activity 5/114 14/18639 0.357142857142857 58.3928571428571 1.50109631676226e-08 8.58627093188014e-07 GO:0004857 enzyme inhibitor activity 15/114 416/18639 0.0360576923076923 5.89543269230769 3.67597958118769e-08 1.75221693369947e-06 GO:0005201 extracellular matrix structural constituent 10/114 168/18639 0.0595238095238095 9.73214285714286 8.22141810528538e-08 3.35903654015945e-06 GO:0061134 peptidase regulator activity 11/114 226/18639 0.0486725663716814 7.95796460176991 1.40577280590356e-07 4.84026872458765e-06 GO:0019838 growth factor binding 9/114 136/18639 0.0661764705882353 10.8198529411765 1.52316148675835e-07 4.84026872458765e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 7/114 68/18639 0.102941176470588 16.8308823529412 1.89453101792706e-07 5.41835871127139e-06 GO:0004866 endopeptidase inhibitor activity 9/114 161/18639 0.0559006211180124 9.13975155279503 6.39338629134567e-07 1.66228043574988e-05 GO:0030414 peptidase inhibitor activity 9/114 169/18639 0.0532544378698225 8.70710059171598 9.60261612251627e-07 2.17419688891313e-05 GO:0001968 fibronectin binding 5/114 30/18639 0.166666666666667 27.25 9.88271313142333e-07 2.17419688891313e-05 GO:0061135 endopeptidase regulator activity 9/114 184/18639 0.0489130434782609 7.99728260869565 1.94748243441159e-06 3.97842840172653e-05 GO:0005518 collagen binding 6/114 72/18639 0.0833333333333333 13.625 5.15780632593893e-06 9.83421739479023e-05 GO:0009055 electron transfer activity 7/114 116/18639 0.0603448275862069 9.86637931034483 7.16026446468166e-06 0.000127989727306185 GO:0022853 active monoatomic ion transmembrane transporter activity 7/114 118/18639 0.0593220338983051 9.69915254237288 8.01536994227455e-06 0.000134846811970031 GO:0015078 proton transmembrane transporter activity 8/114 185/18639 0.0432432432432432 7.07027027027027 1.81784428262055e-05 0.000288835258238598 GO:0015399 primary active transmembrane transporter activity 7/114 166/18639 0.0421686746987952 6.89457831325301 7.24626224345357e-05 0.00109075315875143 GO:0004129 cytochrome-c oxidase activity 3/114 15/18639 0.2 32.7 9.60981434422512e-05 0.00137420345122419 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/114 16/18639 0.1875 30.65625 0.000117747923692132 0.00157607519552629 GO:0005539 glycosaminoglycan binding 8/114 242/18639 0.0330578512396694 5.40495867768595 0.000121236553502023 0.00157607519552629 GO:0030547 signaling receptor inhibitor activity 4/114 44/18639 0.0909090909090909 14.8636363636364 0.00014918962740965 0.0018551405843113 GO:0002020 protease binding 6/114 136/18639 0.0441176470588235 7.21323529411765 0.000188990554145838 0.00225213743690457 GO:0019955 cytokine binding 6/114 144/18639 0.0416666666666667 6.8125 0.000257609385142915 0.00294705136603495 GO:0004896 cytokine receptor activity 5/114 96/18639 0.0520833333333333 8.515625 0.000307604643182431 0.00333940189182123 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/114 22/18639 0.136363636363636 22.2954545454545 0.00031525822055655 0.00333940189182123 GO:0005178 integrin binding 6/114 161/18639 0.0372670807453416 6.09316770186335 0.000467974082621932 0.00478002098678117 GO:0008201 heparin binding 6/114 172/18639 0.0348837209302326 5.70348837209302 0.000663049729892909 0.00653904216377145 GO:0001540 amyloid-beta binding 4/114 83/18639 0.0481927710843374 7.87951807228916 0.00168204925526823 0.0160355362335572 GO:0003953 NAD+ nucleosidase activity 2/114 11/18639 0.181818181818182 29.7272727272727 0.00196726241771136 0.0163880785796309 GO:0008199 ferric iron binding 2/114 11/18639 0.181818181818182 29.7272727272727 0.00196726241771136 0.0163880785796309 GO:0042608 T cell receptor binding 2/114 11/18639 0.181818181818182 29.7272727272727 0.00196726241771136 0.0163880785796309 GO:1990948 ubiquitin ligase inhibitor activity 2/114 11/18639 0.181818181818182 29.7272727272727 0.00196726241771136 0.0163880785796309 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/114 41/18639 0.0731707317073171 11.9634146341463 0.00200553409191288 0.0163880785796309 GO:0008307 structural constituent of muscle 3/114 42/18639 0.0714285714285714 11.6785714285714 0.00215025414590481 0.0170825746035771 GO:0003954 NADH dehydrogenase activity 3/114 44/18639 0.0681818181818182 11.1477272727273 0.00245877494819438 0.0190056658157728 GO:0140375 immune receptor activity 5/114 156/18639 0.032051282051282 5.24038461538461 0.0027188733948813 0.0202054305554838 GO:0004867 serine-type endopeptidase inhibitor activity 4/114 95/18639 0.0421052631578947 6.88421052631579 0.0027552859848387 0.0202054305554838 GO:0005523 tropomyosin binding 2/114 15/18639 0.133333333333333 21.8 0.00369614731642247 0.0257828812804104 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/114 15/18639 0.133333333333333 21.8 0.00369614731642247 0.0257828812804104 GO:0033218 amide binding 6/114 247/18639 0.0242914979757085 3.97165991902834 0.00413388010362378 0.0279415583802207 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/114 16/18639 0.125 20.4375 0.00420734722966966 0.0279415583802207 GO:0042277 peptide binding 6/114 249/18639 0.0240963855421687 3.93975903614458 0.00429870128926472 0.0279415583802207 GO:0005200 structural constituent of cytoskeleton 4/114 112/18639 0.0357142857142857 5.83928571428571 0.00496627053887646 0.0315634083137481 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/114 58/18639 0.0517241379310345 8.45689655172414 0.0053846880028659 0.0334787123656445 GO:0051082 unfolded protein binding 4/114 121/18639 0.0330578512396694 5.40495867768595 0.00651494694672941 0.0396441452503109 GO:1901681 sulfur compound binding 6/114 275/18639 0.0218181818181818 3.56727272727273 0.00690983915369429 0.0411711249574285 GO:0005212 structural constituent of eye lens 2/114 23/18639 0.0869565217391304 14.2173913043478 0.00862661813911519 0.050351281383407 GO:0044183 protein folding chaperone 3/114 75/18639 0.04 6.54 0.0109342475579671 0.0602267916377574 GO:0008198 ferrous iron binding 2/114 26/18639 0.0769230769230769 12.5769230769231 0.0109503257523195 0.0602267916377574 GO:0050750 low-density lipoprotein particle receptor binding 2/114 26/18639 0.0769230769230769 12.5769230769231 0.0109503257523195 0.0602267916377574 GO:0070325 lipoprotein particle receptor binding 2/114 31/18639 0.0645161290322581 10.5483870967742 0.0153598122703713 0.082885024704268 GO:0016651 oxidoreductase activity, acting on NAD(P)H 3/114 88/18639 0.0340909090909091 5.57386363636364 0.0167853365393039 0.0889001157452024 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/114 36/18639 0.0555555555555556 9.08333333333333 0.0204025092561423 0.104198529415298 GO:0055106 ubiquitin-protein transferase regulator activity 2/114 36/18639 0.0555555555555556 9.08333333333333 0.0204025092561423 0.104198529415298 GO:0022804 active transmembrane transporter activity 7/114 457/18639 0.0153172866520788 2.50437636761488 0.0222402654712923 0.109491967641599 GO:0005501 retinoid binding 2/114 38/18639 0.0526315789473684 8.60526315789474 0.0225875038141759 0.109491967641599 GO:0019840 isoprenoid binding 2/114 38/18639 0.0526315789473684 8.60526315789474 0.0225875038141759 0.109491967641599 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/114 39/18639 0.0512820512820513 8.38461538461539 0.0237146827019198 0.113039987545818 GO:0042287 MHC protein binding 2/114 41/18639 0.0487804878048781 7.97560975609756 0.0260368159146084 0.122074251665213 GO:0008237 metallopeptidase activity 4/114 184/18639 0.0217391304347826 3.55434782608696 0.0265048327120191 0.122264228316733 GO:0042056 chemoattractant activity 2/114 42/18639 0.0476190476190476 7.78571428571429 0.0272311440030436 0.123620748966198 GO:0019888 protein phosphatase regulator activity 3/114 107/18639 0.0280373831775701 4.58411214953271 0.0279457329458809 0.124882494101905 GO:0001223 transcription coactivator binding 2/114 44/18639 0.0454545454545455 7.43181818181818 0.0296847794567307 0.129968239126245 GO:0004222 metalloendopeptidase activity 3/114 110/18639 0.0272727272727273 4.45909090909091 0.029992670567595 0.129968239126245 GO:0030291 protein serine/threonine kinase inhibitor activity 2/114 46/18639 0.0434782608695652 7.10869565217391 0.0322230293311233 0.137549050577631 GO:0005504 fatty acid binding 2/114 47/18639 0.0425531914893617 6.95744680851064 0.0335231361174025 0.140994366611428 GO:0019208 phosphatase regulator activity 3/114 117/18639 0.0256410256410256 4.19230769230769 0.0350684991008833 0.145356387577574 GO:0004864 protein phosphatase inhibitor activity 2/114 53/18639 0.0377358490566038 6.16981132075472 0.0417391426066329 0.168132320922493 GO:0017046 peptide hormone binding 2/114 53/18639 0.0377358490566038 6.16981132075472 0.0417391426066329 0.168132320922493 GO:0140463 chromatin-protein adaptor activity 2/114 54/18639 0.037037037037037 6.05555555555555 0.0431750455398548 0.171500875338868 GO:0019212 phosphatase inhibitor activity 2/114 56/18639 0.0357142857142857 5.83928571428571 0.0461014063923699 0.180616468879696 GO:0016504 peptidase activator activity 2/114 57/18639 0.0350877192982456 5.73684210526316 0.0475913211072625 0.18393402481996 GO:0005125 cytokine activity 4/114 234/18639 0.0170940170940171 2.7948717948718 0.0555860983640166 0.21196832176145 GO:0005507 copper ion binding 2/114 63/18639 0.0317460317460317 5.19047619047619 0.0568883830624263 0.214079967840183 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/114 10/18639 0.1 16.35 0.0595198609732176 0.220430555259791 GO:0019843 rRNA binding 2/114 65/18639 0.0307692307692308 5.03076923076923 0.0601174241617611 0.220430555259791 GO:0034713 type I transforming growth factor beta receptor binding 1/114 11/18639 0.0909090909090909 14.8636363636364 0.0652751208287684 0.227666884841802 GO:0048185 activin binding 1/114 11/18639 0.0909090909090909 14.8636363636364 0.0652751208287684 0.227666884841802 GO:0050786 RAGE receptor binding 1/114 11/18639 0.0909090909090909 14.8636363636364 0.0652751208287684 0.227666884841802 GO:0050998 nitric-oxide synthase binding 1/114 11/18639 0.0909090909090909 14.8636363636364 0.0652751208287684 0.227666884841802 GO:0097110 scaffold protein binding 2/114 70/18639 0.0285714285714286 4.67142857142857 0.0684555136564182 0.235882854285971 GO:0097371 MDM2/MDM4 family protein binding 1/114 12/18639 0.0833333333333333 13.625 0.0709954684895763 0.241722666524033 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/114 13/18639 0.0769230769230769 12.5769230769231 0.0766811138748871 0.25500928567695 GO:0039706 co-receptor binding 1/114 13/18639 0.0769230769230769 12.5769230769231 0.0766811138748871 0.25500928567695 GO:0017022 myosin binding 2/114 76/18639 0.0263157894736842 4.30263157894737 0.0789277639642292 0.258758549194996 GO:0005161 platelet-derived growth factor receptor binding 1/114 14/18639 0.0714285714285714 11.6785714285714 0.0823322656529533 0.258758549194996 GO:0032036 myosin heavy chain binding 1/114 14/18639 0.0714285714285714 11.6785714285714 0.0823322656529533 0.258758549194996 GO:0043176 amine binding 1/114 14/18639 0.0714285714285714 11.6785714285714 0.0823322656529533 0.258758549194996 GO:0044548 S100 protein binding 1/114 14/18639 0.0714285714285714 11.6785714285714 0.0823322656529533 0.258758549194996 GO:0033293 monocarboxylic acid binding 2/114 79/18639 0.0253164556962025 4.13924050632911 0.0843403063409454 0.262188343625113 GO:0048306 calcium-dependent protein binding 2/114 80/18639 0.025 4.0875 0.0861691505083978 0.263530662370555 GO:0033130 acetylcholine receptor binding 1/114 15/18639 0.0666666666666667 10.9 0.0879491312484196 0.263530662370555 GO:0120283 protein serine/threonine kinase binding 1/114 15/18639 0.0666666666666667 10.9 0.0879491312484196 0.263530662370555 GO:0005126 cytokine receptor binding 4/114 275/18639 0.0145454545454545 2.37818181818182 0.0884578447117946 0.263530662370555 GO:0005521 lamin binding 1/114 16/18639 0.0625 10.21875 0.0935319168496698 0.265051647904034 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/114 16/18639 0.0625 10.21875 0.0935319168496698 0.265051647904034 GO:0016722 oxidoreductase activity, acting on metal ions 1/114 16/18639 0.0625 10.21875 0.0935319168496698 0.265051647904034 GO:0019841 retinol binding 1/114 16/18639 0.0625 10.21875 0.0935319168496698 0.265051647904034 GO:0004860 protein kinase inhibitor activity 2/114 84/18639 0.0238095238095238 3.89285714285714 0.0936021553786974 0.265051647904034 GO:0030548 acetylcholine receptor regulator activity 1/114 17/18639 0.0588235294117647 9.61764705882353 0.099080827416127 0.269877301342974 GO:0048038 quinone binding 1/114 17/18639 0.0588235294117647 9.61764705882353 0.099080827416127 0.269877301342974 GO:0051787 misfolded protein binding 1/114 17/18639 0.0588235294117647 9.61764705882353 0.099080827416127 0.269877301342974 GO:0070492 oligosaccharide binding 1/114 17/18639 0.0588235294117647 9.61764705882353 0.099080827416127 0.269877301342974 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/114 18/18639 0.0555555555555556 9.08333333333333 0.104596066685516 0.275719441335396 GO:0098641 cadherin binding involved in cell-cell adhesion 1/114 18/18639 0.0555555555555556 9.08333333333333 0.104596066685516 0.275719441335396 GO:0099602 neurotransmitter receptor regulator activity 1/114 18/18639 0.0555555555555556 9.08333333333333 0.104596066685516 0.275719441335396 GO:0019210 kinase inhibitor activity 2/114 90/18639 0.0222222222222222 3.63333333333333 0.105081884984469 0.275719441335396 GO:0043178 alcohol binding 2/114 92/18639 0.0217391304347826 3.55434782608696 0.108990139472161 0.283374362627618 GO:0016918 retinal binding 1/114 19/18639 0.0526315789473684 8.60526315789474 0.110077837181078 0.283623976880975 GO:0016410 N-acyltransferase activity 2/114 94/18639 0.0212765957446809 3.47872340425532 0.112936666536972 0.285839704686495 GO:0042562 hormone binding 2/114 94/18639 0.0212765957446809 3.47872340425532 0.112936666536972 0.285839704686495 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/114 20/18639 0.05 8.175 0.115526340218745 0.287308985239661 GO:0042288 MHC class I protein binding 1/114 20/18639 0.05 8.175 0.115526340218745 0.287308985239661 GO:0036122 BMP binding 1/114 21/18639 0.0476190476190476 7.78571428571429 0.120941775914274 0.295635452234892 GO:0072542 protein phosphatase activator activity 1/114 21/18639 0.0476190476190476 7.78571428571429 0.120941775914274 0.295635452234892 GO:0031681 G-protein beta-subunit binding 1/114 23/18639 0.0434782608695652 7.10869565217391 0.131674239783576 0.319142648966973 GO:0005516 calmodulin binding 3/114 207/18639 0.0144927536231884 2.3695652173913 0.133693319584062 0.321313356311275 GO:0050431 transforming growth factor beta binding 1/114 24/18639 0.0416666666666667 6.8125 0.136991662251597 0.326496795032973 GO:0005496 steroid binding 2/114 108/18639 0.0185185185185185 3.02777777777778 0.14151226785233 0.333534151723493 GO:0019211 phosphatase activator activity 1/114 25/18639 0.04 6.54 0.142276805979951 0.333534151723493 GO:0005160 transforming growth factor beta receptor binding 1/114 26/18639 0.0384615384615385 6.28846153846154 0.147529865189056 0.340270495516694 GO:0019865 immunoglobulin binding 1/114 26/18639 0.0384615384615385 6.28846153846154 0.147529865189056 0.340270495516694 GO:0015252 proton channel activity 1/114 27/18639 0.037037037037037 6.05555555555555 0.152751032941082 0.343990515127161 GO:0023026 MHC class II protein complex binding 1/114 27/18639 0.037037037037037 6.05555555555555 0.152751032941082 0.343990515127161 GO:0035255 ionotropic glutamate receptor binding 1/114 27/18639 0.037037037037037 6.05555555555555 0.152751032941082 0.343990515127161 GO:0001221 transcription coregulator binding 2/114 115/18639 0.0173913043478261 2.84347826086957 0.156327704568753 0.349294714895808 GO:0004181 metallocarboxypeptidase activity 1/114 29/18639 0.0344827586206897 5.63793103448276 0.163098460572363 0.353379997906787 GO:0004629 phospholipase C activity 1/114 29/18639 0.0344827586206897 5.63793103448276 0.163098460572363 0.353379997906787 GO:0043236 laminin binding 1/114 29/18639 0.0344827586206897 5.63793103448276 0.163098460572363 0.353379997906787 GO:0051861 glycolipid binding 1/114 29/18639 0.0344827586206897 5.63793103448276 0.163098460572363 0.353379997906787 GO:0001965 G-protein alpha-subunit binding 1/114 30/18639 0.0333333333333333 5.45 0.168225100846127 0.359047603298451 GO:0048019 receptor antagonist activity 1/114 30/18639 0.0333333333333333 5.45 0.168225100846127 0.359047603298451 GO:0008528 G protein-coupled peptide receptor activity 2/114 122/18639 0.0163934426229508 2.68032786885246 0.171423029432609 0.363162862353527 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/114 32/18639 0.03125 5.109375 0.178385176802752 0.375133533570493 GO:0001653 peptide receptor activity 2/114 128/18639 0.015625 2.5546875 0.184547325643331 0.385259380540093 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/114 130/18639 0.0153846153846154 2.51538461538462 0.188954720420206 0.391601811885355 GO:0016229 steroid dehydrogenase activity 1/114 35/18639 0.0285714285714286 4.67142857142857 0.193395073125665 0.395078506528144 GO:0061631 ubiquitin conjugating enzyme activity 1/114 35/18639 0.0285714285714286 4.67142857142857 0.193395073125665 0.395078506528144 GO:0051087 protein-folding chaperone binding 2/114 134/18639 0.0149253731343284 2.44029850746269 0.19781228885878 0.401236273855398 GO:0023023 MHC protein complex binding 1/114 37/18639 0.027027027027027 4.41891891891892 0.203250339436954 0.40367775749284 GO:0030280 structural constituent of skin epidermis 1/114 37/18639 0.027027027027027 4.41891891891892 0.203250339436954 0.40367775749284 GO:0043394 proteoglycan binding 1/114 37/18639 0.027027027027027 4.41891891891892 0.203250339436954 0.40367775749284 GO:0019887 protein kinase regulator activity 3/114 255/18639 0.0117647058823529 1.92352941176471 0.205121941898017 0.404585347467813 GO:0000217 DNA secondary structure binding 1/114 39/18639 0.0256410256410256 4.19230769230769 0.212986235516958 0.417219612040068 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/114 41/18639 0.024390243902439 3.98780487804878 0.222604194575825 0.42728053455494 GO:0017080 sodium channel regulator activity 1/114 41/18639 0.024390243902439 3.98780487804878 0.222604194575825 0.42728053455494 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/114 41/18639 0.024390243902439 3.98780487804878 0.222604194575825 0.42728053455494 GO:0035198 miRNA binding 1/114 42/18639 0.0238095238095238 3.89285714285714 0.227369390931259 0.431974100566753 GO:0048156 tau protein binding 1/114 43/18639 0.0232558139534884 3.80232558139535 0.232105632767783 0.431974100566753 GO:0008009 chemokine activity 1/114 45/18639 0.0222222222222222 3.63333333333333 0.241491949392299 0.431974100566753 GO:0042605 peptide antigen binding 1/114 45/18639 0.0222222222222222 3.63333333333333 0.241491949392299 0.431974100566753 GO:0005506 iron ion binding 2/114 154/18639 0.012987012987013 2.12337662337662 0.242710929793648 0.431974100566753 GO:0030246 carbohydrate binding 3/114 280/18639 0.0107142857142857 1.75178571428571 0.245258327538875 0.431974100566753 GO:0004180 carboxypeptidase activity 1/114 46/18639 0.0217391304347826 3.55434782608696 0.246142369838103 0.431974100566753 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/114 48/18639 0.0208333333333333 3.40625 0.25535859141688 0.431974100566753 GO:0140693 molecular condensate scaffold activity 1/114 48/18639 0.0208333333333333 3.40625 0.25535859141688 0.431974100566753 GO:0019207 kinase regulator activity 3/114 287/18639 0.0104529616724739 1.70905923344948 0.256726291376392 0.431974100566753 GO:0005004 GPI-linked ephrin receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0005008 hepatocyte growth factor receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0005009 insulin receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0005011 macrophage colony-stimulating factor receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0005020 stem cell factor receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0008288 boss receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0035254 glutamate receptor binding 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0036332 placental growth factor receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0038062 protein tyrosine kinase collagen receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0060175 brain-derived neurotrophic factor receptor activity 1/114 49/18639 0.0204081632653061 3.33673469387755 0.259924732053665 0.431974100566753 GO:0008083 growth factor activity 2/114 162/18639 0.0123456790123457 2.01851851851852 0.260827576624164 0.431974100566753 GO:0005006 epidermal growth factor receptor activity 1/114 50/18639 0.02 3.27 0.264463117236338 0.431974100566753 GO:0005007 fibroblast growth factor receptor activity 1/114 50/18639 0.02 3.27 0.264463117236338 0.431974100566753 GO:0005017 platelet-derived growth factor receptor activity 1/114 50/18639 0.02 3.27 0.264463117236338 0.431974100566753 GO:0005019 platelet-derived growth factor beta-receptor activity 1/114 50/18639 0.02 3.27 0.264463117236338 0.431974100566753 GO:0005010 insulin-like growth factor receptor activity 1/114 51/18639 0.0196078431372549 3.20588235294118 0.268973914193412 0.431974100566753 GO:0005021 vascular endothelial growth factor receptor activity 1/114 51/18639 0.0196078431372549 3.20588235294118 0.268973914193412 0.431974100566753 GO:0005030 neurotrophin receptor activity 1/114 51/18639 0.0196078431372549 3.20588235294118 0.268973914193412 0.431974100566753 GO:0005080 protein kinase C binding 1/114 52/18639 0.0192307692307692 3.14423076923077 0.273457289154782 0.431974100566753 GO:0030159 signaling receptor complex adaptor activity 1/114 52/18639 0.0192307692307692 3.14423076923077 0.273457289154782 0.431974100566753 GO:0005003 ephrin receptor activity 1/114 53/18639 0.0188679245283019 3.08490566037736 0.277913407357631 0.431974100566753 GO:0005005 transmembrane-ephrin receptor activity 1/114 53/18639 0.0188679245283019 3.08490566037736 0.277913407357631 0.431974100566753 GO:0016860 intramolecular oxidoreductase activity 1/114 53/18639 0.0188679245283019 3.08490566037736 0.277913407357631 0.431974100566753 GO:0038064 collagen receptor activity 1/114 53/18639 0.0188679245283019 3.08490566037736 0.277913407357631 0.431974100566753 GO:0015485 cholesterol binding 1/114 54/18639 0.0185185185185185 3.02777777777778 0.282342433052306 0.434139440069675 GO:0050661 NADP binding 1/114 54/18639 0.0185185185185185 3.02777777777778 0.282342433052306 0.434139440069675 GO:0098632 cell-cell adhesion mediator activity 1/114 55/18639 0.0181818181818182 2.97272727272727 0.28674452950816 0.434289216217381 GO:0140313 molecular sequestering activity 1/114 55/18639 0.0181818181818182 2.97272727272727 0.28674452950816 0.434289216217381 GO:0003779 actin binding 4/114 443/18639 0.0090293453724605 1.47629796839729 0.286995321206591 0.434289216217381 GO:0061980 regulatory RNA binding 1/114 58/18639 0.0172413793103448 2.81896551724138 0.299790861543094 0.451264138954341 GO:0004879 nuclear receptor activity 1/114 59/18639 0.0169491525423729 2.77118644067797 0.304086854319806 0.452962710080544 GO:0070888 E-box binding 1/114 59/18639 0.0169491525423729 2.77118644067797 0.304086854319806 0.452962710080544 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/114 60/18639 0.0166666666666667 2.725 0.308356719691579 0.454587741400987 GO:0098531 ligand-modulated transcription factor activity 1/114 60/18639 0.0166666666666667 2.725 0.308356719691579 0.454587741400987 GO:0015026 coreceptor activity 1/114 61/18639 0.0163934426229508 2.68032786885246 0.312600615162549 0.458480902238405 GO:0031406 carboxylic acid binding 2/114 187/18639 0.0106951871657754 1.74866310160428 0.317358769469944 0.463084735042877 GO:0043177 organic acid binding 2/114 189/18639 0.0105820105820106 1.73015873015873 0.321851600984306 0.467256638992444 GO:0038024 cargo receptor activity 1/114 65/18639 0.0153846153846154 2.51538461538462 0.329319615300927 0.475683888768005 GO:0008235 metalloexopeptidase activity 1/114 66/18639 0.0151515151515152 2.47727272727273 0.333435991087278 0.4778852188851 GO:0045296 cadherin binding 3/114 334/18639 0.00898203592814371 1.4685628742515 0.335028226757658 0.4778852188851 GO:0016500 protein-hormone receptor activity 1/114 67/18639 0.0149253731343284 2.44029850746269 0.337527322429336 0.4778852188851 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/114 67/18639 0.0149253731343284 2.44029850746269 0.337527322429336 0.4778852188851 GO:0032934 sterol binding 1/114 68/18639 0.0147058823529412 2.40441176470588 0.341593760359719 0.481260174693988 GO:0008080 N-acetyltransferase activity 1/114 69/18639 0.0144927536231884 2.3695652173913 0.34563545500831 0.484567353590082 GO:0042379 chemokine receptor binding 1/114 72/18639 0.0138888888888889 2.27083333333333 0.357613567133305 0.498914537561587 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 3/114 349/18639 0.00859598853868195 1.4054441260745 0.360123852066633 0.499543588485236 GO:0043539 protein serine/threonine kinase activator activity 1/114 73/18639 0.0136986301369863 2.23972602739726 0.361557772085468 0.499543588485236 GO:0051015 actin filament binding 2/114 209/18639 0.00956937799043062 1.56459330143541 0.36631550639582 0.503683821294253 GO:0098631 cell adhesion mediator activity 1/114 76/18639 0.0131578947368421 2.15131578947368 0.373246929451207 0.510758956091125 GO:0019199 transmembrane receptor protein kinase activity 1/114 78/18639 0.0128205128205128 2.09615384615385 0.380921590572771 0.518778928113393 GO:0046332 SMAD binding 1/114 79/18639 0.0126582278481013 2.06962025316456 0.384723914729589 0.521474121387026 GO:0005254 chloride channel activity 1/114 83/18639 0.0120481927710843 1.96987951807229 0.399703104975627 0.539222113316176 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2/114 229/18639 0.00873362445414847 1.42794759825327 0.409646001981537 0.550041110641876 GO:0008081 phosphoric diester hydrolase activity 1/114 87/18639 0.0114942528735632 1.87931034482759 0.414320741226551 0.553718373788755 GO:0052689 carboxylic ester hydrolase activity 1/114 92/18639 0.0108695652173913 1.77717391304348 0.432097511618485 0.574790178245984 GO:0016407 acetyltransferase activity 1/114 96/18639 0.0104166666666667 1.703125 0.445932971193926 0.590448285932698 GO:0004175 endopeptidase activity 3/114 405/18639 0.00740740740740741 1.21111111111111 0.452002430477925 0.59572670560685 GO:0043130 ubiquitin binding 1/114 100/18639 0.01 1.635 0.459434251119861 0.602744017524221 GO:0008238 exopeptidase activity 1/114 102/18639 0.00980392156862745 1.60294117647059 0.466062081814319 0.608647284926462 GO:0005253 monoatomic anion channel activity 1/114 103/18639 0.00970873786407767 1.5873786407767 0.469345726561213 0.610149444529576 GO:0004620 phospholipase activity 1/114 109/18639 0.00917431192660551 1.5 0.488631427429176 0.63234655314364 GO:0035401 histone H3Y41 kinase activity 1/114 115/18639 0.00869565217391304 1.42173913043478 0.507222149323159 0.650518092853917 GO:0140801 histone H2AXY142 kinase activity 1/114 115/18639 0.00869565217391304 1.42173913043478 0.507222149323159 0.650518092853917 GO:0035091 phosphatidylinositol binding 2/114 284/18639 0.00704225352112676 1.15140845070423 0.520571469768234 0.663776092698794 GO:0032182 ubiquitin-like protein binding 1/114 120/18639 0.00833333333333333 1.3625 0.522201471528771 0.663776092698794 GO:0015108 chloride transmembrane transporter activity 1/114 121/18639 0.00826446280991736 1.35123966942149 0.525142722797507 0.664561144779147 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/114 122/18639 0.00819672131147541 1.34016393442623 0.528066026048457 0.665316667179994 GO:0001664 G protein-coupled receptor binding 2/114 297/18639 0.00673400673400673 1.1010101010101 0.544727295172565 0.679965588321241 GO:0035591 signaling adaptor activity 1/114 129/18639 0.00775193798449612 1.26744186046512 0.548035641708153 0.679965588321241 GO:0016298 lipase activity 1/114 130/18639 0.00769230769230769 1.25769230769231 0.550819214741393 0.679965588321241 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/114 130/18639 0.00769230769230769 1.25769230769231 0.550819214741393 0.679965588321241 GO:0031625 ubiquitin protein ligase binding 2/114 302/18639 0.00662251655629139 1.08278145695364 0.553792924254849 0.679965588321241 GO:0005179 hormone activity 1/114 132/18639 0.00757575757575758 1.23863636363636 0.556335481353743 0.679965588321241 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/114 132/18639 0.00757575757575758 1.23863636363636 0.556335481353743 0.679965588321241 GO:0044325 transmembrane transporter binding 1/114 136/18639 0.00735294117647059 1.20220588235294 0.567167354734813 0.690254738102794 GO:0030295 protein kinase activator activity 1/114 139/18639 0.00719424460431655 1.17625899280576 0.575118849685258 0.691350595659744 GO:0070851 growth factor receptor binding 1/114 139/18639 0.00719424460431655 1.17625899280576 0.575118849685258 0.691350595659744 GO:0140297 DNA-binding transcription factor binding 3/114 488/18639 0.00614754098360656 1.00512295081967 0.576990194809816 0.691350595659744 GO:0004713 protein tyrosine kinase activity 1/114 140/18639 0.00714285714285714 1.16785714285714 0.577737036233143 0.691350595659744 GO:0019903 protein phosphatase binding 1/114 144/18639 0.00694444444444444 1.13541666666667 0.588050817544401 0.698723651189302 GO:0044389 ubiquitin-like protein ligase binding 2/114 322/18639 0.0062111801242236 1.01552795031056 0.588784615163013 0.698723651189302 GO:0019209 kinase activator activity 1/114 148/18639 0.00675675675675676 1.10472972972973 0.598114840701284 0.706859633929736 GO:0008509 monoatomic anion transmembrane transporter activity 1/114 149/18639 0.00671140939597315 1.09731543624161 0.600592527584635 0.706859633929736 GO:0019842 vitamin binding 1/114 150/18639 0.00666666666666667 1.09 0.603055072303691 0.706859633929736 GO:0099106 ion channel regulator activity 1/114 160/18639 0.00625 1.021875 0.62686761015699 0.731771985734283 GO:0015103 inorganic anion transmembrane transporter activity 1/114 165/18639 0.00606060606060606 0.990909090909091 0.638237266410571 0.742015683713103 GO:0016874 ligase activity 1/114 167/18639 0.00598802395209581 0.979041916167665 0.642688366924053 0.743707845841143 GO:0016247 channel regulator activity 1/114 168/18639 0.00595238095238095 0.973214285714286 0.644893516673439 0.743707845841143 GO:0141108 transporter regulator activity 1/114 170/18639 0.00588235294117647 0.961764705882353 0.649263426656 0.745740321379983 GO:0003823 antigen binding 1/114 174/18639 0.00574712643678161 0.939655172413793 0.657843961936163 0.752573492454971 GO:0046982 protein heterodimerization activity 2/114 369/18639 0.00542005420054201 0.886178861788618 0.662952014391122 0.755395522373948 GO:0005319 lipid transporter activity 1/114 178/18639 0.00561797752808989 0.918539325842697 0.666216376798456 0.756102713350629 GO:0016853 isomerase activity 1/114 180/18639 0.00555555555555556 0.908333333333333 0.670326107626247 0.757759947751409 GO:1901981 phosphatidylinositol phosphate binding 1/114 185/18639 0.00540540540540541 0.883783783783784 0.680382297857722 0.766099752705938 GO:0140597 protein carrier chaperone 1/114 188/18639 0.00531914893617021 0.86968085106383 0.686269435342412 0.769698268658549 GO:0019902 phosphatase binding 1/114 190/18639 0.00526315789473684 0.860526315789474 0.690134348815436 0.771009467817245 GO:0003714 transcription corepressor activity 1/114 204/18639 0.00490196078431373 0.801470588235294 0.715898661726811 0.796681000987813 GO:0005216 monoatomic ion channel activity 2/114 448/18639 0.00446428571428571 0.729910714285714 0.763188616735216 0.846015288318883 GO:0042393 histone binding 1/114 247/18639 0.00404858299595142 0.661943319838057 0.78247953858064 0.863684567959754 GO:0140104 molecular carrier activity 1/114 249/18639 0.00401606425702811 0.656626506024096 0.785167789054322 0.863684567959754 GO:0003713 transcription coactivator activity 1/114 256/18639 0.00390625 0.638671875 0.794319914186347 0.867231481606742 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 2/114 484/18639 0.00413223140495868 0.675619834710744 0.799686043399348 0.867231481606742 GO:0001216 DNA-binding transcription activator activity 2/114 491/18639 0.00407331975560081 0.665987780040733 0.806182176067294 0.867231481606742 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/114 268/18639 0.00373134328358209 0.610074626865672 0.809118792278541 0.867231481606742 GO:0003712 transcription coregulator activity 2/114 495/18639 0.00404040404040404 0.660606060606061 0.809810452101407 0.867231481606742 GO:0016755 aminoacyltransferase activity 2/114 496/18639 0.00403225806451613 0.659274193548387 0.810708114922484 0.867231481606742 GO:0005543 phospholipid binding 2/114 497/18639 0.00402414486921529 0.6579476861167 0.811602038575051 0.867231481606742 GO:0005096 GTPase activator activity 1/114 271/18639 0.003690036900369 0.603321033210332 0.812650479267856 0.867231481606742 GO:0008017 microtubule binding 1/114 276/18639 0.0036231884057971 0.592391304347826 0.818393249782414 0.869271779339574 GO:0001217 DNA-binding transcription repressor activity 1/114 278/18639 0.00359712230215827 0.588129496402878 0.820641190285612 0.869271779339574 GO:0005261 monoatomic cation channel activity 1/114 341/18639 0.00293255131964809 0.479472140762463 0.878932559590164 0.923556131292022 GO:0061630 ubiquitin protein ligase activity 1/114 353/18639 0.0028328611898017 0.463172804532578 0.887682577271362 0.923556131292022 GO:0141003 histone H2AX kinase activity 1/114 354/18639 0.00282485875706215 0.461864406779661 0.88838279526278 0.923556131292022 GO:0045182 translation regulator activity 1/114 356/18639 0.00280898876404494 0.459269662921348 0.889770275860585 0.923556131292022 GO:0140996 histone H3 kinase activity 1/114 357/18639 0.00280112044817927 0.457983193277311 0.890457591320405 0.923556131292022 GO:0035173 histone kinase activity 1/114 360/18639 0.00277777777777778 0.454166666666667 0.892494152104879 0.923556131292022 GO:0042578 phosphoric ester hydrolase activity 1/114 363/18639 0.00275482093663912 0.450413223140496 0.894493176111503 0.923556131292022 GO:0061659 ubiquitin-like protein ligase activity 1/114 372/18639 0.00268817204301075 0.439516129032258 0.900271824048009 0.926178926898312 GO:0005525 GTP binding 1/114 378/18639 0.00264550264550265 0.432539682539683 0.903948819018521 0.926628538492104 GO:0015631 tubulin binding 1/114 385/18639 0.0025974025974026 0.424675324675325 0.90806909190752 0.927527715305538 GO:0019001 guanyl nucleotide binding 1/114 400/18639 0.0025 0.40875 0.916317549307002 0.92931496135391 GO:0032561 guanyl ribonucleotide binding 1/114 400/18639 0.0025 0.40875 0.916317549307002 0.92931496135391 GO:0004842 ubiquitin-protein transferase activity 1/114 449/18639 0.0022271714922049 0.364142538975501 0.938477984273117 0.948426514141737 GO:0019787 ubiquitin-like protein transferase activity 1/114 479/18639 0.00208768267223382 0.34133611691023 0.949060580343657 0.952470649697271 GO:0030695 GTPase regulator activity 1/114 489/18639 0.00204498977505112 0.334355828220859 0.952170231315451 0.952470649697271 GO:0060589 nucleoside-triphosphatase regulator activity 1/114 490/18639 0.00204081632653061 0.333673469387755 0.952470649697271 0.952470649697271