category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 8/37 138/9376 14.6901684292989 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 10.1975458824772 Genetic Information Processing Translation hsa03010 Ribosome 9/37 222/9376 10.2731921110299 RPL13A/RPS26/RPL10/RPS11/RPL18A/RPS20/RPL23/RPS2/RPL7 8.80109285081589 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 9/37 238/9376 9.58255734726323 RPL13A/RPS26/RPL10/RPS11/RPL18A/RPS20/RPL23/RPS2/RPL7 8.44142814825202 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 8/37 205/9376 9.88899143045484 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 8.09948459715929 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 9/37 308/9376 7.4047034047034 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/TGM2 7.19374332283778 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 8/37 227/9376 8.93058697463984 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 7.61320912948129 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 8/37 235/9376 8.62656699252444 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 7.45250847690848 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 8/37 268/9376 7.56434045986285 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 6.86251483427017 Human Diseases Neurodegenerative disease hsa05020 Prion disease 8/37 275/9376 7.37179361179361 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 6.75024914377058 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 8/37 368/9376 5.50881316098707 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 5.55403065189 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 8/37 388/9376 5.22485371969908 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 5.34973562071945 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 8/37 480/9376 4.22342342342342 MT-CO3/MT-CO2/MT-CYB/MT-ND3/MT-ND2/MT-ATP6/MT-ND1/MT-ND4 4.56327772955757 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 4/37 149/9376 6.8028296753129 MT-ND3/MT-ND2/MT-ND1/MT-ND4 4.49406148391699 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 3/37 87/9376 8.7381174277726 MT-CO3/MT-CO2/MT-CYB 4.56401195519273 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 4/37 204/9376 4.96873343932167 TIMP3/FN1/DCN/LUM 3.60720898149135 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 4/37 233/9376 4.350307388934 FN1/DCN/MYL9/FBLN1 3.25952689106077 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 3/37 157/9376 4.84214150456189 MT-CO3/MT-CO2/MT-CYB 3.05574835728374 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 2/37 75/9376 6.75747747747748 IGFBP3/SERPINE1 3.15089818308387 Organismal Systems Immune system hsa04612 Antigen processing and presentation 2/37 82/9376 6.18061964403428 HLA-DRB5/CD74 2.96567538550029 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 3/37 203/9376 3.7449074690454 FN1/FLT1/MYL9 2.48860714497444 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 2/37 88/9376 5.75921375921376 SERPINE2/SERPINE1 2.82326573141744 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/37 95/9376 5.3348506401138 HLA-DRB5/FLT1 2.67285172413401 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 2/37 99/9376 5.11930111930112 HLA-DRB5/KRT18 2.59342487090152 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 2/37 101/9376 5.01792881990902 FN1/SERPINE1 2.55530225941954 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 2/37 110/9376 4.60737100737101 FLT1/SERPINE1 2.39539598722278 Metabolism Amino acid metabolism hsa00340 Histidine metabolism 1/37 22/9376 11.5184275184275 AOC1 3.10885014778611 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 2/37 134/9376 3.78217022993142 CALD1/MYL9 2.04168824736139 Human Diseases Immune disease hsa05310 Asthma 1/37 32/9376 7.91891891891892 HLA-DRB5 2.467647537623 NA NA hsa04518 Integrin signaling 2/37 154/9376 3.29097929097929 FN1/FLT1 1.80428557687181 Cellular Processes Cell growth and death hsa04218 Cellular senescence 2/37 157/9376 3.22809433637459 IGFBP3/SERPINE1 1.77205748413116 Human Diseases Immune disease hsa05330 Allograft rejection 1/37 39/9376 6.4975744975745 HLA-DRB5 2.16538966596257 Metabolism Amino acid metabolism hsa00380 Tryptophan metabolism 1/37 42/9376 6.03346203346203 AOC1 2.05775590490856 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 2/37 180/9376 2.81561561561562 HLA-DRB5/CD74 1.54809280830385 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 2/37 181/9376 2.80005972823652 HLA-DRB5/CD74 1.53917020918955 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 1/37 44/9376 5.75921375921376 HLA-DRB5 1.99163842780188 Human Diseases Immune disease hsa05332 Graft-versus-host disease 1/37 45/9376 5.63123123123123 HLA-DRB5 1.96008515724605 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 3/37 362/9376 2.10004479617739 FN1/FLT1/PRL 1.3435139861409 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 1/37 50/9376 5.06810810810811 AOC1 1.81537393138287 Organismal Systems Immune system hsa04672 Intestinal immune network for IgA production 1/37 50/9376 5.06810810810811 HLA-DRB5 1.81537393138287 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 2/37 201/9376 2.52144681995428 IGFBP3/FLT1 1.37242329684815 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 1/37 54/9376 4.69269269269269 HLA-DRB5 1.71285977375012 NA NA hsa04382 Cornified envelope formation 2/37 217/9376 2.3355336903724 KRT18/KRT8 1.25284400165986 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 1/37 66/9376 3.83947583947584 HLA-DRB5 1.45704047955621 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 2/37 232/9376 2.18452935694315 FN1/MYL9 1.14989457451859 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 1/37 70/9376 3.62007722007722 HLA-DRB5 1.384898355838 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/37 71/9376 3.56909021697754 PRL 1.36768679399233 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 1/37 78/9376 3.24878724878725 FN1 1.25527018312332 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/37 78/9376 3.24878724878725 HLA-DRB5 1.25527018312332 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 1/37 89/9376 2.84725174612815 FN1 1.10209664123811 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 1/37 93/9376 2.72478930543447 MYL9 1.0521306254748 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/37 93/9376 2.72478930543447 HLA-DRB5 1.0521306254748 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/37 93/9376 2.72478930543447 FN1 1.0521306254748 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 1/37 100/9376 2.53405405405405 HLA-DRB5 0.970725873289877 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 1/37 103/9376 2.46024665442141 SERPINE1 0.937931269360952 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 1/37 103/9376 2.46024665442141 FN1 0.937931269360952 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/37 109/9376 2.32482023307711 HLA-DRB5 0.875662864142244 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 1/37 110/9376 2.3036855036855 DCN 0.865683906021256 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 1/37 112/9376 2.26254826254826 HLA-DRB5 0.84604612221734 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 1/37 116/9376 2.18452935694315 MYL9 0.807989361085098 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 1/37 122/9376 2.07709348692955 IGFBP3 0.753711045894372 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 1/37 138/9376 1.83627105366236 FN1 0.622922390177359 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/37 139/9376 1.82306047054249 KRT18 0.615332685873207 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 1/37 140/9376 1.81003861003861 SERPINE1 0.60780474755414 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 2/37 370/9376 1.36975894813733 PRL/NPW 0.456761926410465 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 1/37 143/9376 1.77206577206577 HLA-DRB5 0.585581317992095 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 1/37 154/9376 1.64548964548965 MYL9 0.508362367989468 Cellular Processes Transport and catabolism hsa04145 Phagosome 1/37 155/9376 1.63487358326068 HLA-DRB5 0.501649527244806 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 1/37 157/9376 1.6140471681873 SERPINE1 0.488366610978587 Cellular Processes Cell growth and death hsa04110 Cell cycle 1/37 158/9376 1.60383167978105 CDKN1C 0.481795121856226 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 1/37 160/9376 1.58378378378378 HLA-DRB5 0.468788660381233 NA NA hsa04519 Cadherin signaling 2/37 404/9376 1.25448220497725 KRT18/KRT8 0.329109017279183 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 1/37 166/9376 1.52653858677955 MYL9 0.430814929450174 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 1/37 168/9376 1.50836550836551 PRL 0.418489315945803 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 1/37 170/9376 1.4906200317965 MYL9 0.406322212109969 Human Diseases Infectious disease: viral hsa05164 Influenza A 1/37 173/9376 1.46477112951101 HLA-DRB5 0.388359377200748 Organismal Systems Development and regeneration hsa04360 Axon guidance 1/37 184/9376 1.37720329024677 MYL9 0.325248789217796 Cellular Processes Cell motility hsa04814 Motor proteins 1/37 194/9376 1.30621342992477 MYL9 0.271264378447668 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 1/37 205/9376 1.23612392880686 HLA-DRB5 0.2151517570193 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 1/37 212/9376 1.19530851606323 FLT1 0.181043477517976 NA NA hsa04081 Hormone signaling 1/37 219/9376 1.15710230778724 PRL 0.148069062823387 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 1/37 224/9376 1.13127413127413 HLA-DRB5 0.125164586497435 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 1/37 226/9376 1.12126285577613 MYL9 0.116146941193818 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 1/37 238/9376 1.06472859414036 FLT1 0.0636642150427856 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/37 248/9376 1.02179598953792 MYL9 0.0218953014078936 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 1/37 253/9376 1.00160239290674 MYL9 0.00162628534895355 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 1/37 254/9376 0.997659076399234 FLT1 -0.00238064904797394 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 1/37 298/9376 0.850353709414112 PRL -0.165240047610546 NA NA hsa04517 IgSF CAM signaling 1/37 299/9376 0.847509717074934 MYL9 -0.168671966845664 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 1/37 300/9376 0.844684684684685 FLT1 -0.172093306516249 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 1/37 323/9376 0.784536858840264 TIMP3 -0.248035760980927 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 1/37 333/9376 0.760977193409626 FN1 -0.279538419539241