category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	85/336	238/9376	9.96598639455782	RPL10/RPL13/RPS12/RPL13A/RPS18/RPS8/RPL18A/RPLP1/RPS14/RPS28/RPL41/RPS15/RPL28/RPS2/RPLP2/RPL8/RPL19/RPS19/RPL36/RPL11/RPS6/RPL21/RPS4X/RPS27/RPS24/RPL3/RPL37A/RPL32/RPLP0/RPS11/RPL18/RPS23/RPS3A/RPL12/RPL9/RPL23/RPS27A/RPL34/RPL35A/RPL15/RPS3/RPS26/RPL29/RPS20/RPS16/RPL23A/RPL39/RPL27A/RPL7A/RPL7/RPL5/RPS13/RPL35/RPL10A/RPL37/C1QB/RPL14/RPL26/RPS5/RPS15A/RPS7/RPL22/RPL30/RPL6/RPL24/RPS29/RPSA/C1QA/UBA52/RPS25/RPL27/RPL31/RPS21/RPS9/RPL38/RPL4/C1QC/IL6ST/JUN/RPS27L/CCL2/CFD/FAU/PIK3R1/C1R	27.0104636295789
Genetic Information Processing	Translation	hsa03010	Ribosome	79/336	222/9376	9.93007293007293	RPL10/RPL13/RPS12/RPL13A/RPS18/RPS8/RPL18A/RPLP1/RPS14/RPS28/RPL41/RPS15/RPL28/RPS2/RPLP2/RPL8/RPL19/RPS19/RPL36/RPL11/RPS6/RPL21/RPS4X/RPS27/RPS24/RPL3/RPL37A/RPL32/RPLP0/RPS11/RPL18/RPS23/RPS3A/RPL12/RPL9/RPL23/RPS27A/RPL34/RPL35A/RPL15/RPS3/RPS26/RPL29/RPS20/RPS16/RPL23A/RPL39/RPL27A/RPL7A/RPL7/RPL5/RPS13/RPL35/RPL10A/RPL37/RPL14/RPL26/RPS5/RPS15A/RPS7/RPL22/RPL30/RPL6/RPL24/RPS29/RPSA/UBA52/RACK1/RPS25/RPL27/RPL31/RPS21/RPS9/RPL38/RPL4/RPS27L/FAU/MRPS6/MRPL41	25.9595464546676
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	52/336	275/9376	5.2765367965368	MT-CO1/C1QB/MT-CO3/C1QA/COX6C/MT-CO2/MT-CYB/MT-ATP6/C1QC/MT-ND4/NDUFS5/CAV1/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/HSPA8/MT-ND3/PSMB1/TUBB/UQCR10/PIK3R1/ATP5PO/COX5A/COX5B/TUBA1B/PSMD8/TUBA1C/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/TUBB4B/RAC1/NDUFAB1/ATP5PF/CYBA/PSMB4	13.876663739707
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	50/336	268/9376	5.20611229566453	MT-CO1/RPS27A/MT-CO3/UBA52/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/GNAS/UBB/NDUFS5/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/UBC/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/MT-ND3/PSMB1/TUBB/PARK7/UQCR10/ATP5PO/COX5A/COX5B/TUBA1B/PSMD8/TUBA1C/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/TUBB4B/NDUFAB1/ATP5PF/PSMB4	13.4681458581301
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	42/336	227/9376	5.16299559471366	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/JUN/NDUFS5/NDUFA4/COX7C/MT-ND5/MGST3/NDUFB11/NDUFB2/COX4I1/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/MT-ND3/MGST1/UQCR10/PIK3R1/ATP5PO/COX5A/COX5B/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/HMOX1/RAC1/NDUFAB1/ATP5PF/CYBA	12.2406118811051
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/336	205/9376	5.44483159117305	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/GAPDH/MT-ND4/NDUFS5/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/CTSD/ATP5PD/UQCRQ/MT-ND3/UQCR10/PIK3R1/ATP5PO/COX5A/COX5B/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/MMP2/RAC1/NDUFAB1/ATP5PF/CYBA	12.4049482322038
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/336	138/9376	6.67287784679089	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/NDUFS5/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/MT-ND3/UQCR10/ATP5PO/COX5A/COX5B/COX7B/ATP5MC3/COX7A1/NDUFA12/NDUFB10/NDUFAB1/ATP5PF	12.9427051625995
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/336	308/9376	4.34879406307978	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/TGM2/MT-ND4/POLR2L/NDUFS5/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/MT-ND3/PSMB1/TUBB/UQCR10/ATP5PO/COX5A/COX5B/AP2S1/TUBA1B/PSMD8/TUBA1C/COX7B/CLTB/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/TUBB4B/NDUFAB1/ATP5PF/PSMB4	11.5207063009983
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/336	235/9376	4.393515704154	RPS6/MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/GNAS/NDUFS5/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/ATP5F1D/ACTG1/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/MT-ND3/UQCR10/ATP5PO/COX5A/MGLL/COX5B/COX7B/ATP5MC3/COX7A1/NDUFA12/NDUFB10/NDUFAB1/ATP5PF	10.1568257466062
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	46/336	368/9376	3.48809523809524	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/NDUFS5/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/ATP5F1D/ACTG1/UQCRB/HNRNPA1/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/MT-ND3/PSMB1/TUBB/UQCR10/ATP5PO/COX5A/COX5B/TUBA1B/PSMD8/TUBA1C/COX7B/ATP5MC3/COX7A1/NDUFA12/NDUFB10/TUBB4B/RAC1/NDUFAB1/ATP5PF/PSMB4	9.38745314366646
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	47/336	388/9376	3.38021600392734	MT-CO1/MT-CO3/APOE/DKK1/COX6C/MT-CO2/MT-CYB/MT-ATP6/GAPDH/MT-ND4/NDUFS5/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/MT-ND3/PSMB1/TUBB/UQCR10/PIK3R1/ATP5PO/COX5A/COX5B/TUBA1B/PSMD8/TUBA1C/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/TUBB4B/NDUFAB1/ATP5PF/PSMB4	9.23148914866392
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	51/336	480/9376	2.96488095238095	MT-CO1/RPS27A/MT-CO3/UBA52/DKK1/COX6C/MT-CO2/MT-CYB/MT-ATP6/MT-ND4/UBB/NDUFS5/SEM1/NDUFA4/COX7C/MT-ND5/NDUFB11/NDUFB2/COX4I1/PSMA7/UBC/ATP5F1D/UQCRB/ATP5MC2/UQCRH/NDUFB7/ATP5PD/UQCRQ/SOD1/MT-ND3/PSMB1/TUBB/PARK7/UQCR10/ATP5PO/COX5A/COX5B/TUBA1B/PSMD8/TUBA1C/COX7B/ATP5MC3/COX7A1/SLC25A6/NDUFA12/NDUFB10/TUBB4B/RAC1/NDUFAB1/ATP5PF/PSMB4	8.51982228341417
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/336	157/9376	4.62117076129815	MT-CO1/MT-CO3/COX6C/MT-CO2/MT-CYB/JUN/NDUFS5/NDUFA4/COX7C/NDUFB11/NDUFB2/COX4I1/UQCRB/UQCRH/NDUFB7/UQCRQ/UQCR10/PIK3R1/COX5A/COX5B/COX7B/COX7A1/NDUFA12/NDUFB10/RAC1/NDUFAB1	8.82120643127821
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/336	87/9376	5.77339901477832	MT-CO1/MT-CO3/COX6C/MT-CO2/TPM1/MT-CYB/COX7C/COX4I1/UQCRB/UQCRH/UQCRQ/TPM2/UQCR10/COX5A/COX5B/COX7B/ATP1B3/COX7A1	8.62330894365336
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/336	82/9376	5.44483159117305	HLA-DRA/CD74/HSP90AB1/HLA-DRB1/HLA-DPA1/HSP90AA1/HLA-DPB1/CTSB/CTSL/PDIA3/CANX/HLA-DRB5/CALR/HSPA8/HLA-G/PSME2	7.79348967804966
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/336	155/9376	3.78064516129032	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB1/CTSL/ACTG1/CANX/HLA-DRB5/CALR/TUBB/HLA-G/SEC61G/TUBA1B/C1R/SEC61B/TUBA1C/ITGB2/TUBB4B/RAC1/CYBA	6.72966540231299
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/336	174/9376	3.52818828680898	HSP90AB1/SSR4/HSP90B1/HSP90AA1/CRYAB/PDIA3/RPN2/TMEM258/CANX/LMAN1/SSR3/CALR/HSPA8/SKP1/P4HB/SEC61G/SEC61B/BCAP31/PDIA6/RBX1/SELENOS/DNAJC1	6.48954108427377
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/336	88/9376	4.12229437229437	SERPINE2/C1QB/C1QA/SERPINE1/C1QC/CD59/SERPING1/CFD/F2R/TFPI/C1R/CLU/ITGB2	5.67316141738013
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/336	142/9376	3.14419852448021	GSTP1/HSP90AB1/HSP90B1/HSP90AA1/JUN/CTSL/CAV1/MGST3/CCL2/ACTG1/MGST1/PIK3R1/MMP2/HMOX1/RAC1/CYBA	4.9634687460429
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/336	99/9376	3.66426166426166	HLA-DRA/C1QB/KRT18/C1QA/HLA-DRB1/HLA-DPA1/KRT19/HLA-DPB1/C1QC/CFD/HLA-DRB5/C1R/ITGB2	5.13761736907554
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/336	95/9376	3.52481203007519	HLA-DRA/FLT1/HLA-DRB1/HLA-DPA1/HLA-DPB1/JUN/CTSL/CCL2/HLA-DRB5/CXCL2/ACP5/ITGB2	4.76831051118186
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/336	70/9376	3.98639455782313	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CAV1/ACTG1/HLA-DRB5/HLA-G/ITGB2/RAC1	4.83488048473192
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/336	78/9376	3.57753357753358	EEF1A1/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB1/JUN/HLA-DRB5/ITGB2/CYBA	4.40684650273269
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/336	248/9376	2.25038402457757	RPS3/S100A10/HSP90AB1/ANXA2/GAPDH/DYNLL1/HSP90B1/HSP90AA1/MYL9/JUN/ACTG1/AHNAK/SKP1/TUBB/MYL12B/RHOB/TUBA1B/TUBA1C/TUBB4B/RAC1	3.84726855322119
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/336	31/9376	5.40092165898618	SRP14/SEC11A/SEC61G/SEC61B/SPCS2/SPCS1	4.7315767975035
Human Diseases	Immune disease	hsa05310	Asthma	6/336	32/9376	5.23214285714286	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/PRG2/HLA-DRB5	4.62317097542055
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/336	109/9376	2.81607688947138	HLA-DRA/HSP90AB1/HLA-DRB1/HLA-DPA1/HSP90AA1/HLA-DPB1/IL6ST/JUN/EBI3/HLA-DRB5/GATA3	3.67662182532734
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/336	110/9376	2.79047619047619	RPS6/FLT1/SERPINE1/TIMP1/GAPDH/EPAS1/PIK3R1/ENO1/ELOB/RBX1/HMOX1	3.64157959172349
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/336	39/9376	4.29304029304029	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-G	3.97280025841298
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/336	116/9376	2.64614121510673	MYL9/ITGB1/THY1/CD99/ACTG1/PIK3R1/MYL12B/ITGB2/MMP2/RAC1/CYBA	3.4392334144382
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/336	44/9376	3.80519480519481	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-G	3.59561398406938
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/336	45/9376	3.72063492063492	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-G	3.52682160001396
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/336	46/9376	3.63975155279503	SEM1/PSMA7/PSMB1/PSMD8/PSME2/PSMB4	3.45996901549955
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/336	78/9376	2.86202686202686	C1QB/C1QA/C1QC/ITGB1/JUN/SERPING1/C1R/ITGB2	3.1835343044374
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/336	149/9376	2.24736337488015	MT-ND4/NDUFS5/NDUFA4/MT-ND5/NDUFB11/NDUFB2/NDUFB7/MT-ND3/MGLL/NDUFA12/NDUFB10/NDUFAB1	2.95887707973054
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/336	66/9376	2.95959595959596	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/JUN/HLA-DRB5/GATA3	3.07988658579659
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/336	51/9376	3.28291316526611	GNAS/KDELR2/ACTG1/KDELR1/SEC61G/SEC61B	3.15152765234084
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/336	233/9376	1.91620682607807	FN1/DCN/VIM/TPM1/FBLN1/MYL9/ITGB1/VCAN/LMNA/PDLIM1/ACTG1/TPM2/ENO1/ATP1B3/ITGB8/FBN1	2.73022340525313
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/336	137/9376	2.24052832811957	CTSB/JUN/CTSL/LMNA/CTSZ/ACTG1/CTSD/PIK3R1/TUBA1B/TUBA1C/CTSH	2.81984701851539
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/336	139/9376	2.20829051044878	KRT18/HSP90AB1/KRT19/HSP90B1/HSP90AA1/GNAS/JUN/CTSD/HSPA8/PIK3R1/MMP2	2.76684196884085
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/336	103/9376	2.43828016643551	C1QB/C1QA/SERPINE1/C1QC/GNAS/JUN/CCL2/CALR/PIK3R1	2.82958689744854
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/336	54/9376	3.1005291005291	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-G	2.98429736089521
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/336	105/9376	2.39183673469388	RPS27A/UBA52/JUN/UBB/CITED2/TOMM7/UBC/TOMM20/FIS1	2.76497185727522
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/336	205/9376	1.90569105691057	HLA-DRA/VIM/HLA-DRB1/HLA-DPA1/HLA-DPB1/JUN/SEM1/PDIA3/HLA-DRB5/CALR/PIK3R1/HLA-G/PSMD8/RAC1	2.52766622196826
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/336	78/9376	2.5042735042735	FN1/ITGB1/CAV1/ACTG1/PIK3R1/CLTB/RAC1	2.57187820528976
NA	NA	hsa04518	Integrin signaling	11/336	154/9376	1.99319727891156	FN1/FLT1/ITGB1/SPP1/FERMT2/ACTG1/PIK3R1/ITGB8/ITGB2/FBN1/RAC1	2.39582109306534
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/336	200/9376	1.81380952380952	RPS3/GAPDH/ITGB1/JUN/TMED10/NCL/ACTG1/F2R/TUBB/TUBA1B/TUBA1C/TUBB4B/RAC1	2.24275650515971
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/336	160/9376	1.91845238095238	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB1/VCAN/CD99/HLA-DRB5/HLA-G/ITGB8/ITGB2	2.2590012138443
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/336	224/9376	1.74404761904762	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/JUN/CANX/HLA-DRB5/CALR/PIK3R1/HLA-G/ANAPC11/SLC25A6/ITGB2/ANAPC16	2.17289027594076
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	13/336	203/9376	1.7870044569552	FN1/FLT1/MYL9/ITGB1/JUN/SPP1/CAV1/ACTG1/EMP1/PIK3R1/MYL12B/ITGB8/RAC1	2.18544849447647
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/336	103/9376	2.16736014794267	FN1/HSPB1/PRDX1/GNAS/PIK3R1/SERPINB6/CXCL2/ITGB2	2.29659495855274
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/336	204/9376	1.77824463118581	TIMP3/FN1/DCN/LUM/RPS6/CD63/ITGB1/CTSL/CAV1/ACTG1/PIK3R1/MMP2/RAC1	2.16655767990088
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/336	50/9376	2.79047619047619	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5	2.44724194917441
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/336	143/9376	1.95138195138195	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DPA1/HLA-DPB1/C1QC/HLA-DRB5/C1R/SSB	2.21015417866679
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/336	250/9376	1.67428571428571	CD63/HEXB/CTSB/PSAP/CTSL/NPC2/CTSZ/CTSD/CD68/AP2S1/VAMP8/CLTB/LAPTM4A/ACP5/CTSH	2.08326631848869
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/336	52/9376	2.68315018315018	APOE/NPC2/LRPAP1/APOC1/PLTP	2.34635904594071
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/336	70/9376	2.39183673469388	JUN/EPAS1/PIK3R1/ELOB/RBX1/RAC1	2.2533406541598
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/336	93/9376	2.10035842293907	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/JUN/HLA-DRB5/GATA3	2.05590258647296
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/336	94/9376	2.07801418439716	HSP90AB1/JUND/HSP90B1/HSP90AA1/JUN/CCL2/CXCL2	2.02506366670081
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/336	180/9376	1.70529100529101	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/PDIA3/CCL2/HLA-DRB5/CALR/PIK3R1/HLA-G	1.84194296428007
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/336	59/9376	2.36481033091203	GSTP1/GPX4/PRDX6/MGST3/MGST1	2.02736208845845
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/336	100/9376	1.95333333333333	IL6ST/CXCL14/CCL2/CCL4/CCL4L2/CXCL2/CCL21	1.84771706598813
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/336	100/9376	1.95333333333333	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CD59/CD9/HLA-DRB5	1.84771706598813
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/336	142/9376	1.76861167002012	RPS27A/UBA52/UBB/UBC/SKP1/ANAPC11/ELOB/RBX1/ANAPC16	1.77921025429001
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/336	101/9376	1.93399339933993	FN1/SERPINE1/JUN/CCL2/PIK3R1/MMP2/RAC1	1.81935980829441
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/336	232/9376	1.5636288998358	FN1/RGCC/MYL9/ITGB1/TMSB4X/ACTG1/F2R/PIK3R1/MYL12B/GSN/ITGB8/ITGB2/RAC1	1.67586950615931
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/336	105/9376	1.86031746031746	TPM1/ITGB1/GNAS/LMNA/ACTG1/TPM2/ITGB8	1.70907514279931
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/336	15/9376	3.72063492063492	HEXB/ST3GAL5	2.03294597109795
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/336	112/9376	1.74404761904762	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/ITGB1/HLA-DRB5/HSPA8	1.52714941832215
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/336	34/9376	2.46218487394958	RORB/SKP1/RBX1	1.64661806446303
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/336	53/9376	2.10601976639712	GNAS/AP2S1/ATP1B3/CLTB	1.55666099298772
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/336	253/9376	1.43384152079804	RPS27A/UBA52/MYL9/ITGB1/JUN/UBB/UBC/ACTG1/SKP1/PIK3R1/MYL12B/RBX1/RAC1	1.3486324295811
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/336	56/9376	1.99319727891156	EEF1A1/HSPA8/CXCL2/ITGB2	1.43711869832616
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/336	99/9376	1.69119769119769	TPM1/ITGB1/LMNA/ACTG1/TPM2/ITGB8	1.33286805549044
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/336	169/9376	1.48605240912933	RPS27A/UBA52/CTSB/UBB/CTSL/UBC/CTSD/PIK3R1/VAMP8	1.22924497733712
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/336	170/9376	1.47731092436975	MYL9/ITGB1/JUN/ACTG1/YBX3/MYL12B/TUBA1B/TUBA1C/RAC1	1.21076933021236
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/336	194/9376	1.43838978890525	TPM1/DYNLL1/MYL9/ACTG1/TPM2/TUBB/MYL12B/TUBA1B/TUBA1C/TUBB4B	1.18949798941803
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/336	196/9376	1.42371234207969	RPS27A/UBA52/IL6ST/JUN/UBB/UBC/PIK3R1/HLA-G/CXCL2/RAC1	1.15571000035179
Organismal Systems	Immune system	hsa04611	Platelet activation	7/336	126/9376	1.55026455026455	ITGB1/GNAS/ACTG1/F2R/PIK3R1/MYL12B/VAMP8	1.19882834542364
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/336	173/9376	1.45169281585467	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/CCL2/ACTG1/HLA-DRB5/PIK3R1/SLC25A6	1.15603926554314
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/336	106/9376	1.57951482479784	GSTP1/HSP90AB1/HSP90B1/HSP90AA1/PIK3R1/FOLR2	1.15677442295092
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/336	62/9376	1.80030721966206	CRYAB/SOD1/HSPA8/PIK3R1	1.21886476981886
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/336	42/9376	1.99319727891156	GPX4/SLC40A1/HMOX1	1.24364758144635
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/336	109/9376	1.53604193971166	JUN/SPP1/CCL4/PIK3R1/CCL4L2/RAC1	1.08520928065351
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/336	110/9376	1.52207792207792	DCN/EMP3/SKP1/RBX1/LTBP1/FBN1	1.06183389449191
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/336	44/9376	1.9025974025974	HEXB/RPN2/TMEM258	1.1569220920964
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/336	89/9376	1.56768325307651	GNAS/TUBB/TUBA1B/TUBA1C/TUBB4B	1.03737176848627
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/336	67/9376	1.66595593461265	GAPDH/PKM/ENO1/TPI1	1.05463563432833
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/336	138/9376	1.41545893719807	FN1/ITGB1/JUN/CCL2/ACTG1/PIK3R1/RAC1	0.947872081251205
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/336	362/9376	1.23335964219942	FN1/RPS6/FLT1/HSP90AB1/HSP90B1/HSP90AA1/ITGB1/SPP1/PRL/PRLR/F2R/PIK3R1/ITGB8/YWHAE/RAC1/CSH1	0.872955931599361
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/336	70/9376	1.59455782312925	GSTP1/HSD11B1/MGST3/MGST1	0.962570738873735
NA	NA	hsa03272	Virion - Hepatitis viruses	3/336	48/9376	1.74404761904762	CD81/CD63/CD9	0.996318381602662
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/336	216/9376	1.29188712522046	HSP90AB1/HSP90B1/HSP90AA1/JUN/CCL2/HSPA8/PIK3R1/CXCL2/RAC1/CYBA	0.836691081231955
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/336	144/9376	1.35648148148148	SEM1/PSMA7/PSMB1/PIK3R1/PSMD8/SLC25A6/PSMB4	0.831077230427961
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/336	50/9376	1.67428571428571	CD81/CCL2/ITGB2	0.921620904263556
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/336	75/9376	1.48825396825397	GAPDH/PKM/ENO1/TPI1	0.818432096595851
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/336	75/9376	1.48825396825397	GSTP1/MGST3/MGST1/PIK3R1	0.818432096595851
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/336	75/9376	1.48825396825397	HSP90B1/GNAS/CANX/ATP1B3	0.818432096595851
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/336	79/9376	1.41289933694997	GSTP1/HSD11B1/MGST3/MGST1	0.710489030838691
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/336	181/9376	1.23335964219942	HLA-DRA/CD74/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/CTSD/ITGB2	0.611167472967584
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/336	59/9376	1.41888619854722	GNAS/PIK3R1/MGLL	0.622235910059099
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/336	187/9376	1.19378660555131	HSP90AB1/HSP90AA1/CTSB/JUN/CCL2/CXCL2/YWHAE/CYBA	0.516037775765844
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/336	110/9376	1.26839826839827	HSP90AB1/HSP90AA1/PIK3R1/ANAPC11/ANAPC16	0.545884755045592
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/336	214/9376	1.17356475300401	JUN/PDIA3/CALR/SKP1/PIK3R1/HLA-G/ELOB/RBX1/RAC1	0.495158614669171
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/336	60/9376	1.3952380952381	HSPB1/PIK3R1/RAC1	0.592094115052768
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/336	86/9376	1.29789590254707	ITGB1/LMNA/ACTG1/ITGB8	0.535028553284778
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/336	61/9376	1.37236533957845	ATP1B3/SLC40A1/HMOX1	0.562488695647716
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/336	298/9376	1.12368168744008	IL6ST/CXCL14/PRL/EBI3/IL1RL1/PRLR/CCL2/CCL4/CCL4L2/CXCL2/CSH1/CCL21	0.418301581322214
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/336	37/9376	1.50836550836551	MIF/COMT	0.597307286657905
NA	NA	hsa04517	IgSF CAM signaling	12/336	299/9376	1.11992355470616	DYNLL1/MYL9/ITGB1/ACTG1/TUBB/PIK3R1/MYL12B/TUBA1B/TUBA1C/ITGB2/TUBB4B/RAC1	0.406293599937263
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/336	193/9376	1.15667406859117	CXCL14/CCL2/CCL4/PIK3R1/CCL4L2/CXCL2/RAC1/CCL21	0.423988957219852
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/336	63/9376	1.32879818594104	GPX4/HPGD/PTGDS	0.504807673205899
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/336	115/9376	1.21325051759834	JUND/NACA/GNAS/NR4A2/GATA3	0.443589373417479
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/336	89/9376	1.25414660246121	FN1/ITGB1/SPP1/ITGB8	0.464421856768123
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/336	38/9376	1.468671679198	PIK3R1/ATP1B3	0.558090507892493
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/336	142/9376	1.17907444668008	JUND/JUN/PIK3R1/ACP5/RAC1/CYBA	0.414528043538772
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/336	91/9376	1.22658294086866	CD81/JUN/PIK3R1/RAC1	0.418724153319075
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/336	227/9376	1.10635619886721	GNAS/PDIA3/CCL2/CCL4/CALR/PIK3R1/HLA-G/CCL4L2/RAC1	0.31272311532982
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/336	93/9376	1.20020481310804	MYL9/ACTG1/MYL12B/RAC1	0.374061382648175
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/336	93/9376	1.20020481310804	CST3/GNAS/LYZ/ATP1B3	0.374061382648175
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/336	41/9376	1.36120789779326	SEM1/SSBP1	0.446851341882859
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/336	16/9376	1.74404761904762	MIF	0.574240553897098
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/336	16/9376	1.74404761904762	HEXB	0.574240553897098
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/336	205/9376	1.08896631823461	IL6ST/JUN/PKM/PIK3R1/HLA-G/GSN/YWHAE/RAC1	0.248293450375441
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/336	71/9376	1.17907444668008	PRL/PRLR/PIK3R1	0.291995168327551
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/336	71/9376	1.17907444668008	JUN/CXCL2/RAC1	0.291995168327551
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/336	44/9376	1.26839826839827	DYNLL1/GNAS	0.34402479477207
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/336	99/9376	1.12746512746513	GNAS/JUN/PIK3R1/MMP2	0.245796823037556
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/336	18/9376	1.55026455026455	HEXB	0.450492255051778
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/336	18/9376	1.55026455026455	PRDX1	0.450492255051778
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/336	73/9376	1.146771037182	GSTP1/MGST3/MGST1	0.242695288020364
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/336	212/9376	1.05300988319856	FLT1/ITGB1/GNAS/ACTG1/F2R/PIK3R1/ITGB2/RAC1	0.15050582170551
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/336	157/9376	1.06642402183803	C1QB/C1QA/C1QC/MFGE8/CALR/RAC1	0.161809549246162
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/336	157/9376	1.06642402183803	IGFBP3/SERPINE1/ZFP36L2/PIK3R1/HLA-G/SLC25A6	0.161809549246162
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/336	19/9376	1.468671679198	HEXB	0.394228718469265
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/336	158/9376	1.05967450271248	CDKN1C/SKP1/ANAPC11/RBX1/YWHAE/ANAPC16	0.145837785748059
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/336	47/9376	1.18743667679838	PKM/PIK3R1	0.24834591446649
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/336	76/9376	1.1015037593985	GNAS/ACTG1/ATP1B3	0.17128467621399
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/336	48/9376	1.16269841269841	PIK3R1/ATP1B3	0.217861619443782
NA	NA	hsa04382	Cornified envelope formation	8/336	217/9376	1.02874698266403	KRT18/S100A10/KRT8/KRT19/KRT7/S100A4/S100A6/S100A13	0.0825979304968856
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/336	217/9376	1.02874698266403	HSP90AB1/HSP90B1/HSP90AA1/GNAS/JUN/MGST3/MGST1/PIK3R1	0.0825979304968856
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/336	133/9376	1.04905119942714	PIK3R1/HLA-G/ITGB2/RAC1/HCST	0.109834818595041
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/336	105/9376	1.06303854875283	CCL4/CCL4L2/CXCL2/CCL21	0.125230071085453
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/336	49/9376	1.13896987366375	GNAS/JUN	0.188026376177912
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/336	22/9376	1.26839826839827	AOC1	0.242976028359833
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/336	138/9376	1.01104209799862	SKP1/ANAPC11/RBX1/YWHAE/ANAPC16	0.0251926134551815
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/336	82/9376	1.02090592334495	GSTP1/MGST3/MGST1	0.0366560789665257
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/336	23/9376	1.21325051759834	SSBP1	0.197401117290106
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/336	23/9376	1.21325051759834	ATP1B3	0.197401117290106
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/336	170/9376	0.984873949579832	GSTP1/MGST3/ACTG1/MGST1/PIK3R1/HMOX1	-0.0383694506053215
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/336	83/9376	1.00860585197935	PRDX1/SOD1/PRDX5	0.015181895970213
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/336	83/9376	1.00860585197935	POLR2L/CCL4/CCL4L2	0.015181895970213
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/336	55/9376	1.01471861471861	HEXB/PSAP	0.0211051328171683
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/336	56/9376	0.996598639455782	RPN2/TMEM258	-0.00492163937782937
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/336	116/9376	0.962233169129721	GAPDH/PKM/ENO1/TPI1	-0.0789051057676596
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/336	87/9376	0.962233169129721	JUN/PIK3R1/RAC1	-0.068227074545589
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/336	178/9376	0.940609951845907	DKK1/NOTUM/JUN/SKP1/RBX1/RAC1	-0.154222606068283
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/336	119/9376	0.93797519007603	JUN/CCL2/PIK3R1/CXCL2	-0.13127283139068
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/336	27/9376	1.03350970017637	TECR	0.0336156029867109
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/336	120/9376	0.93015873015873	JUN/PIK3R1/YWHAE/RAC1	-0.148443825791118
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/336	28/9376	0.996598639455782	TECR	-0.00347490867330987
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/336	122/9376	0.914910226385636	IGFBP3/GNAS/PIK3R1/CSH1	-0.182374283051098
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/336	184/9376	0.909937888198758	MYL9/ITGB1/DPYSL2/PIK3R1/MYL12B/RAC1	-0.237857632323159
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/336	154/9376	0.90599876314162	MYL9/EEF2/GNAS/JUN/ACTG1	-0.226752681286384
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/336	93/9376	0.900153609831029	GNAS/JUN/MMP2	-0.186552351960087
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/336	93/9376	0.900153609831029	FN1/ITGB1/PIK3R1	-0.186552351960087
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/336	63/9376	0.885865457294029	POLR2L/RBX1	-0.175232088859979
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/336	30/9376	0.93015873015873	FOLR2	-0.0738636777286129
NA	NA	hsa04081	Hormone signaling	7/336	219/9376	0.89193302891933	GNAS/PRL/RAMP1/PRLR/PIK3R1/SLC40A1/CSH1	-0.311967599481439
NA	NA	hsa04981	Folate transport and metabolism	1/336	31/9376	0.900153609831029	FOLR2	-0.107348164690306
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/336	65/9376	0.858608058608059	SPP1/PIK3R1	-0.220523173803536
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/336	98/9376	0.854227405247813	PIK3R1/GSN/RAC1	-0.279661575334496
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/336	98/9376	0.854227405247813	GNAS/NR4A2/ATP1B3	-0.279661575334496
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/336	130/9376	0.858608058608059	GNAS/JUN/PIK3R1/MMP2	-0.312961165804151
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/336	66/9376	0.845598845598846	HSD11B1/COMT	-0.242671476200467
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/336	99/9376	0.845598845598846	JUN/PIK3R1/RAC1	-0.297738793188888
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/336	33/9376	0.845598845598846	VAMP8	-0.171291337401366
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/336	195/9376	0.858608058608059	ACTG1/PIK3R1/SLC25A6/ITGB2/RAC1/CYBA	-0.384652032219343
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/336	226/9376	0.864306784660767	MYL9/GNAS/JUN/F2R/PIK3R1/ATP1B3/RAC1	-0.398082299790111
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/336	34/9376	0.820728291316527	POLR2L	-0.20188420713723
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/336	134/9376	0.832977967306325	CALD1/MYL9/GNAS/RAMP1	-0.375417266855388
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/336	102/9376	0.820728291316527	GNAS/ATP1B3/RAC1	-0.350953323603474
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/336	69/9376	0.808833678398896	PIK3R1/RAC1	-0.307257246059351
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/336	69/9376	0.808833678398896	CTSB/GNAS	-0.307257246059351
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/336	69/9376	0.808833678398896	GNAS/JUN	-0.307257246059351
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/336	35/9376	0.797278911564626	TPI1	-0.231636677581946
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/336	136/9376	0.820728291316527	RACK1/JUN/HSPA8/PIK3R1	-0.405990889550887
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/336	168/9376	0.830498866213152	IL6ST/PRL/PRLR/PIK3R1/CSH1	-0.427381436766933
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/336	71/9376	0.786049631120054	PKM/PIK3R1	-0.348863141185352
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/336	36/9376	0.775132275132275	SSBP1	-0.260600953142732
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/336	38/9376	0.734335839598998	HEXB	-0.316350769179702
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/336	38/9376	0.734335839598998	NNMT	-0.316350769179702
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/336	75/9376	0.744126984126984	IGFBP3/SERPINE1	-0.428905246980661
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/336	76/9376	0.734335839598998	UBC/PLTP	-0.448300634041555
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/336	144/9376	0.775132275132275	C1QB/C1QA/C1QC/CXCL2	-0.524241666689252
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/336	77/9376	0.724799010513296	PIK3R1/RAC1	-0.467464129744991
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/336	78/9376	0.715506715506716	PABPC1/ENO1	-0.486402290448468
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/336	41/9376	0.680603948896632	MMP2	-0.395125784623106
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/336	79/9376	0.706449668474985	AP2S1/CLTB	-0.505121398567069
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/336	42/9376	0.664399092970521	AOC1	-0.420227949895114
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/336	80/9376	0.697619047619048	RPS6/PIK3R1	-0.523627477482571
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/336	117/9376	0.715506715506716	ACTG1/MORF4L1/MORF4L2	-0.596972011018456
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/336	250/9376	0.781333333333333	CAV1/HSPA8/HLA-G/AP2S1/CLTB/DAB2/FOLR2	-0.675590320233054
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/336	154/9376	0.724799010513296	TPM1/GNAS/TPM2/ATP1B3	-0.663848310345005
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/336	46/9376	0.606625258799172	HMOX1	-0.515603225839149
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/336	156/9376	0.715506715506716	CD81/EIF3E/PIK3R1/YWHAE	-0.69078026169403
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/336	122/9376	0.686182669789227	ACTG1/PIK3R1/ATP1B3	-0.67260974116093
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/336	86/9376	0.648947951273533	JUN/PIK3R1	-0.630498332309572
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/336	86/9376	0.648947951273533	GNAS/ATP1B3	-0.630498332309572
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/336	157/9376	0.710949347892023	SERPINE1/ACTG1/ITGB2/YWHAE	-0.704130138957043
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/336	47/9376	0.59371833839919	PKM	-0.538306549735472
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/336	125/9376	0.669714285714286	CTSD/PIK3R1/RAC1	-0.716673782669257
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/336	90/9376	0.62010582010582	GNAS/ATP1B3	-0.698136937855404
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/336	90/9376	0.62010582010582	JUN/PIK3R1	-0.698136937855404
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/336	50/9376	0.558095238095238	AOC1	-0.604000140647302
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/336	333/9376	0.754182754182754	FN1/ITGB1/GNAS/SPP1/PKM/PIK3R1/HLA-G/BCAP31/ITGB8	-0.880540349002817
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/336	52/9376	0.536630036630037	GNAS	-0.645950858131663
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/336	168/9376	0.664399092970521	HSP90AB1/PPIA/HSP90AA1/SLC25A6	-0.846186657411453
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/336	56/9376	0.498299319727891	GAS1	-0.725941808229822
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/336	99/9376	0.563732563732564	GNAS/PIK3R1	-0.841274409415331
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/336	57/9376	0.489557226399332	TECR	-0.745196649290678
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/336	140/9376	0.597959183673469	RPS6/SERPINE1/SPP1	-0.923981473753828
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/336	59/9376	0.472962066182405	PIK3R1	-0.782890268340253
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/336	60/9376	0.465079365079365	GNAS	-0.801348260131658
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/336	105/9376	0.531519274376417	JUN/PIK3R1	-0.930666643390454
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/336	107/9376	0.521584334668447	GNAS/PKM	-0.959515293507609
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/336	149/9376	0.561840843720038	GNAS/F2R/PIK3R1	-1.03935958911365
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/336	65/9376	0.429304029304029	MGLL	-0.890090945041214
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/336	65/9376	0.429304029304029	GNAS	-0.890090945041214
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/336	68/9376	0.410364145658263	DHRS3	-0.940765136729204
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/336	68/9376	0.410364145658263	PIK3R1	-0.940765136729204
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/336	73/9376	0.382257012393999	PPIA	-1.0214775011346
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/336	73/9376	0.382257012393999	PIK3R1	-1.0214775011346
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/336	73/9376	0.382257012393999	PIK3R1	-1.0214775011346
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/336	201/9376	0.555318644870884	IGFBP3/FLT1/HPGD/NUPR1	-1.22861262679531
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/336	122/9376	0.457455113192818	EEF2/PIK3R1	-1.16284519927076
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/336	122/9376	0.457455113192818	JUN/PIK3R1	-1.16284519927076
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/336	76/9376	0.367167919799499	PIK3R1	-1.0678859442971
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/336	77/9376	0.362399505256648	PIK3R1	-1.08304610734176
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/336	166/9376	0.504302925989673	MYL9/ATP1B3/SLC25A6	-1.24225755295903
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/336	78/9376	0.357753357753358	TPI1	-1.09805838959611
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/336	83/9376	0.336201950659782	SKP1	-1.17103024250244
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/336	133/9376	0.419620479770856	GNAS/COMT	-1.29957840104059
NA	NA	hsa04519	Cadherin signaling	9/336	404/9376	0.621640735502122	VIM/KRT18/KRT8/KRT19/KRT7/ACTG1/YWHAE/RAC1/CDH11	-1.49872338685494
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/336	138/9376	0.404416839199448	RPS6/PIK3R1	-1.35882658823885
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/336	300/9376	0.558095238095238	FLT1/HSPB1/JUND/JUN/HSPA8/RAC1	-1.49973016535199
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/336	90/9376	0.31005291005291	PIK3R1	-1.26792558072903
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/336	91/9376	0.306645735217164	GNAS	-1.28131524976391
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/336	144/9376	0.387566137566138	IL6ST/PIK3R1	-1.42778759810073
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/336	97/9376	0.287677957781051	GNAS	-1.3595109968359
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/336	148/9376	0.377091377091377	JUN/PIK3R1	-1.47255820281478
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/336	98/9376	0.284742468415938	PIK3R1	-1.37220612964126
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/336	101/9376	0.276284771334276	GNAS	-1.40975129012212
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/336	243/9376	0.45933764452283	HNRNPA1/SNRPD2/HSPA8/SNU13	-1.64624171297976
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/336	103/9376	0.270920018492834	PABPC1	-1.43434861371789
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/336	103/9376	0.270920018492834	ATP1B3	-1.43434861371789
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/336	158/9376	0.353224834237492	RPS6/PIK3R1	-1.58064590007745
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/336	108/9376	0.258377425044092	EEF1A1	-1.49442067768748
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/336	370/9376	0.527927927927928	NPW/PRL/PRLR/F2R/TAC3/PGRMC2/CSH1	-1.78613491713623
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/336	109/9376	0.256006989951944	PIK3R1	-1.50620326402032
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/336	163/9376	0.342389716622845	JUN/PIK3R1	-1.63279974596861
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/336	254/9376	0.439445069366329	FLT1/GNAS/F2R/SLC25A6	-1.74606763752039
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/336	115/9376	0.242650103519669	PIK3R1	-1.57538827957392
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/336	115/9376	0.242650103519669	GNAS	-1.57538827957392
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/336	116/9376	0.24055829228243	GNAS	-1.58667875728446
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/336	183/9376	0.304970075461879	REXO2/SNU13	-1.83050736258526
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/336	323/9376	0.431962258587646	TIMP3/VIM/TPM1/PIK3R1/HMOX1	-2.00287227391989
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/336	238/9376	0.351740696278511	FLT1/PIK3R1/RAC1	-1.95291221458171
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/336	133/9376	0.209810239885428	PIK3R1	-1.7693828075858
NA	NA	hsa04082	Neuroactive ligand signaling	2/336	199/9376	0.280449868389567	GNAS/TAC3	-1.97791803733544
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/336	150/9376	0.186031746031746	PIK3R1	-1.93739169226794
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/336	154/9376	0.181199752628324	DHRS3	-1.97513519752087
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/336	155/9376	0.180030721966206	GNAS	-1.98447430767577
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/336	191/9376	0.146098229867863	GNAS	-2.29856123875976