category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	41/394	238/9376	4.09947532312417	RPS26/RPL13A/C1QB/C1QA/RPS20/RPS11/RPL10/RPL28/RPS28/RPL8/C1QC/RPS14/RPL18A/RPS27/RPS15/RPLP0/RPL37A/RPL7/UBA52/RPS16/RPLP2/RPL21/RPS8/RPS5/RPL23/RPS9/RPL13/RPS27A/RPS2/RPL27A/RPL31/RPL18/OAS3/RPL11/RPL36/RPL19/IRF3/CYBB/NFKBIB/MAPK14/RPS3A	10.1437446572811
Genetic Information Processing	Translation	hsa03010	Ribosome	37/394	222/9376	3.96615905245347	RPS26/RPL13A/RPS20/RPS11/RPL10/RPL28/RPS28/RPL8/RPS14/RPL18A/RPS27/RPS15/RPLP0/RPL37A/RPL7/UBA52/RPS16/RPLP2/RPL21/RPS8/RPS5/RPL23/RPS9/RPL13/DAP3/RPS27A/RPS2/RPL27A/RPL31/RPL18/MRPS5/RPL11/RPL36/RPL19/MRPS12/MRPL21/RPS3A	9.36726253129455
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/394	70/9376	4.75939086294416	HLA-DRA/HLA-DPA1/HLA-DRB1/ACTB/HLA-DRB5/HLA-G/RAC1/HLA-E/HLA-DQA1/CAV1/HLA-DPB1/HLA-DMA/HLA-DMB/EIF4G1	6.61199020002855
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/394	39/9376	6.10178315762072	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	6.68648452148343
Human Diseases	Immune disease	hsa05310	Asthma	9/394	32/9376	6.69289340101523	HLA-DRA/PRG2/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	6.75598769319385
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/394	44/9376	5.40839870789109	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	6.13856789051448
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/394	45/9376	5.28821206993796	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	6.03900849893855
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/394	155/9376	2.91704601277223	HLA-DRA/HLA-DPA1/HLA-DRB1/CD14/ACTB/HLA-DRB5/HLA-G/RAC1/HLA-E/HLA-DQA1/MRC2/ATP6V1H/HLA-DPB1/HLA-DMA/CTSL/HLA-DMB/CYBB/FCGR3A/STX7	5.04030246258046
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/394	82/9376	3.77268787916306	CD74/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/CTSL/HLA-DMB/RFXANK	5.28145762654823
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	14/394	99/9376	3.36522586268779	HLA-DRA/C1QB/C1QA/KRT18/HLA-DPA1/HLA-DRB1/HLA-DRB5/KRT19/C1QC/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/FCGR3A	4.9548859435579
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/394	54/9376	4.40684339161497	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	5.2582559799851
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/394	78/9376	3.66106989457243	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/CYBB/NFKBIB/FCGR3A/MAPK14	4.94260649883794
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	24/394	250/9376	2.2845076142132	LAPTM5/HEXB/GGA1/PSAP/PLEKHM1/VAMP8/NAGLU/VPS26B/ATP6V1H/MANBA/CTSZ/NPC2/STX17/CTSD/SLC36A4/CTSL/GLB1/GGA2/ACP5/OSBPL5/AP3M2/AP5Z1/AP5M1/AP2A1	4.31135395186043
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/394	250/9376	2.2845076142132	HLA-G/RAB31/HLA-E/PML/ACAP3/FOLR2/WASHC1/VPS36/VPS26B/ARAP1/CAV1/SH3GL1/ITCH/DNM2/SNX4/SH3KBP1/EPN2/CXCR4/RUFY2/ACAP2/CHMP1B/ASAP3/SMAP2/AP2A1	4.31135395186043
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/394	95/9376	3.25642532727758	FLT1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/CCL5/HLA-DQA1/ATP6V1H/HLA-DPB1/HLA-DMA/CTSL/HLA-DMB/ACP5	4.6294841963106
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/394	50/9376	4.28345177664975	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/CXCR4	4.87545511612489
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/394	181/9376	2.4980228286171	CD74/HLA-DRA/HLA-DPA1/HLA-DRB1/CD14/HLA-DRB5/HLA-DQA1/MRC2/ATP6V1H/TRADD/HLA-DPB1/HLA-DMA/CTSD/HLA-DMB/EP300/CREBBP/FCGR3A/RFXANK/MAPK14	4.26215339664913
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/394	169/9376	2.53458685008861	UBA52/RPS27A/PLEKHM1/VAMP8/ZFYVE1/GABARAP/STX17/NBR1/CTSD/CTSL/PDPK1/ATG12/IRS2/MTMR3/ATG14/MRAS/PRKAA1/STX7	4.2162172122172
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/394	173/9376	2.47598368592471	HLA-DRA/HLA-DPA1/HLA-DRB1/TNFSF10/ACTB/HLA-DRB5/PML/CCL5/HLA-DQA1/OAS3/TRADD/HLA-DPB1/HLA-DMA/IRF3/HLA-DMB/EP300/NFKBIB/CREBBP	4.10380882956928
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/394	100/9376	2.8556345177665	HLA-DRA/HLA-DPA1/HLA-DRB1/CD14/HLA-DRB5/HLA-DQA1/CD59/HLA-DPB1/HLA-DMA/CD9/HLA-DMB/EPOR	3.90714290756102
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/394	205/9376	2.20557137551071	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/RAC1/PSMD13/HLA-E/HLA-DQA1/OAS3/SIN3A/TRADD/HLA-DPB1/HLA-DMA/PSMD14/IRF3/HLA-DMB/NFKBIB/MAPK14	3.65517971872156
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/394	180/9376	2.24749012972363	CD74/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/PML/CCL5/HLA-DQA1/OAS3/TRADD/HLA-DPB1/HLA-DMA/IRF3/HLA-DMB/SRSF8	3.53933045522538
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/394	33/9376	4.32671896631287	VAMP8/STX16/STX17/GOSR1/STX4/STX7	4.00937920434328
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/394	142/9376	2.34617859440909	UBA52/CUL4B/PML/RPS27A/CUL4A/RCHY1/UBR5/ITCH/UBE2J2/UBE2E2/UBE2G2/UBE2E3/PRPF19/KLHL9	3.38531543530746
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/394	116/9376	2.46175389462629	ACTB/MYL9/CLDN12/RAC1/CLDN5/BCAR1/PXN/CYBB/THY1/CXCR4/EZR/MAPK14	3.31776013597745
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/394	93/9376	2.55881229190546	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/NFKBIB/MAPK14	3.16401362155352
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/394	109/9376	2.40152749965072	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/EBI3/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/NFKBIB/MAPK14	3.08242497447838
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/394	66/9376	2.88447931087525	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB	3.2176272022702
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/394	112/9376	2.33720087019579	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DMA/PDPK1/HLA-DMB/NFKBIB/MAPK14	2.98162905919064
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/394	78/9376	2.44071326304829	FN1/ACTB/RAC1/CAV1/BCAR1/PXN/SHC1/DNM2	2.67594577332537
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/394	248/9376	1.72719829703619	S100A10/TNFSF10/CD14/GAPDH/ACTB/MYL9/PAK3/RAC1/SNX18/DCTN4/PLEKHM1/FBXO22/TRADD/DNM2/PIK3C2A/ACTR1B/EXOC7/MAPK14	2.43073772697322
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/394	143/9376	1.99694721522133	HLA-DRA/C1QB/C1QA/HLA-DPA1/HLA-DRB1/HLA-DRB5/C1QC/HLA-DQA1/HLA-DPB1/HLA-DMA/HLA-DMB/FCGR3A	2.51603100893127
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/394	15/9376	4.75939086294416	HEXB/GLB1/ST3GAL5	3.05175181970846
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/394	204/9376	1.749776052553	FN1/ACTB/TIMP3/RAC1/PTCH1/CAV1/CTSL/PDPK1/PXN/ITPR3/WNT5B/HSPG2/MRAS/EZR/MAPK14	2.26757598867629
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/394	122/9376	1.95057002579679	ACTB/MED24/SIN3A/PDPK1/MED4/EP300/BMP4/CREBBP/NCOA2/NCOA3	2.21333171512166
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/394	122/9376	1.95057002579679	IGFBP3/CSH1/BCAR1/GNA11/SHC1/IRS2/EP300/ITPR3/CREBBP/MAPK14	2.21333171512166
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/394	73/9376	2.28189972880884	CPSF7/NELFCD/EP300/NELFB/CXCR4/CREBBP/MLLT3	2.30277337263966
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/394	160/9376	1.78477157360406	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/CLDN12/HLA-E/HLA-DQA1/CLDN5/HLA-DPB1/HLA-DMA/HLA-DMB	2.09690736683841
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/394	18/9376	3.96615905245347	HEXB/MANBA/GLB1	2.63807046112813
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/394	253/9376	1.5990048353765	CD14/ACTB/MYL9/UBA52/RAC1/RPS27A/CCL5/BCAR1/TRADD/PXN/PRKCE/IRF3/ATG12/ITPR3/NFKBIB/ATG14/MAPK14	2.02287466439723
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/394	144/9376	1.81782289904117	C1QB/C1QA/CD14/C1QC/TRADD/CPT1A/IRF3/LPIN2/ADIPOR2/PRKAA1/MAPK14	2.07128489721163
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/394	19/9376	3.75741383916644	HEXB/NAGLU/GLB1	2.51975119838922
NA	NA	hsa03272	Virion - Hepatitis viruses	5/394	48/9376	2.47884940778342	CLDN12/CLDN5/CD9/HSPG2/CHMP1B	2.15128290170373
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	10/394	133/9376	1.78924468531735	TNFSF10/CSNK1E/GABARAP/PDPK1/ATG12/IRS2/EP300/CREBBP/PRKAA1/MAPK14	1.91989834306359
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/394	214/9376	1.55681009535557	HLA-G/PAK3/RAC1/HLA-E/CUL4B/CUL4A/TRADD/DCAF1/GNA11/PXN/IRF3/ITPR3/CXCR4/MAPK14	1.72570305304357
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/394	70/9376	2.03973894126178	TRADD/CPT1A/IRS2/NFKBIB/ADIPOR2/PRKAA1	1.8286855346632
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/394	105/9376	1.81310128112159	UBA52/RPS27A/FUNDC1/GABARAP/CCZ1/NBR1/AMFR/MRAS	1.75478223105834
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/394	72/9376	1.98307952622673	TRADD/OTUD5/IRF3/ATG12/NFKBIB/MAPK14	1.75374833861113
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/394	224/9376	1.48730964467005	HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-G/HLA-E/HLA-DQA1/HLA-DPB1/HLA-DMA/TRRAP/HLA-DMB/EP300/CREBBP/VAC14	1.54603112891019
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/394	42/9376	2.26637660140198	FTL/FTH1/GPX4/CYBB	1.72266507193605
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/394	170/9376	1.53980292624664	ACTB/MYL9/MYL6/CLDN12/RAC1/TJAP1/MAGI1/CLDN5/PRKCE/PRKAA1/EZR	1.48754952522316
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/394	78/9376	1.83053494728622	PARN/TENT4A/EXOSC4/CNOT10/EXOSC7/PAN2	1.54261541056908
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/394	78/9376	1.83053494728622	C1QB/C1QA/CD14/C1QC/IRF3/MAPK14	1.54261541056908
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/394	44/9376	2.16335948315644	HEXB/ALG3/MAN1B1/ST3GAL3	1.61994448361635
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/394	44/9376	2.16335948315644	TDG/UNG/POLD2/FEN1	1.61994448361635
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/394	14/9376	3.39956490210297	B4GALT4/ST3GAL3	1.88173916551282
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	16/394	275/9376	1.38455006922012	C1QB/C1QA/C1QC/PSMA7/RAC1/PSMD13/NDUFV3/CCL5/CAV1/COX4I1/PSMD14/CYBB/ITPR3/NDUFA13/MAPK14/NDUFB6	1.35556987017563
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/394	62/9376	1.9191092189291	PSENEN/ITCH/EP300/CREBBP/DVL3	1.52069484567304
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/394	29/9376	2.46175389462629	STK3/CSNK1E/LATS1	1.65114175786988
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/394	137/9376	1.56330356812035	TNFSF10/ACTB/TRADD/CTSZ/CTSD/CTSL/PDPK1/ITPR3/CSF2RB	1.39103329759531
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/394	196/9376	1.45695638661556	HLA-G/UBA52/RAC1/HLA-E/RPS27A/TRADD/IRF3/EP300/ITPR3/ATG14/CREBBP/MAPK14	1.35403119627385
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/394	157/9376	1.51572957418604	RAC1/NDUFV3/COX4I1/ITCH/IRS2/NDUFA13/ADIPOR2/PRKAA1/MAPK14/NDUFB6	1.36482565964151
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/394	100/9376	1.66578680203046	TNFSF10/CCL4/CCL18/CCL5/CXCL14/CCL21/CXCR4	1.40185158046751
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/394	200/9376	1.42781725888325	TNFSF10/GAPDH/ACTB/PAK3/CLDN12/RAC1/CLDN5/SEC24C/TRADD/NFKBIB/EZR/MAPK14	1.28083686786099
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/394	122/9376	1.56045602063743	EEF2/PDPK1/CPT1A/IRS2/PPP2R3C/ADIPOR2/PRKAA1/PPP2R5D	1.30498022422694
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/394	203/9376	1.40671651121502	FN1/FLT1/SPP1/ACTB/MYL9/PAK3/RAC1/CAV1/BCAR1/PDPK1/PXN/SHC1	1.22696266959522
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/394	49/9376	1.94260851548741	GALNT15/GALNT6/C1GALT1/ST3GAL3	1.38549714188755
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/394	205/9376	1.39299244769097	GAPDH/RAC1/NDUFV3/COX4I1/CTSD/CYBB/MPC1/PDHB/NDUFA13/MAPK14/PTPA/NDUFB6	1.19151636609012
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/394	125/9376	1.52300507614213	RAC1/TRADD/CTSD/PDPK1/PRKCE/PPP2R3C/MAPK14/PPP2R5D	1.23286008978656
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/394	227/9376	1.36282117220868	HLA-G/CCL4/RAC1/HLA-E/CCL5/BCAR1/TRADD/GNA11/PXN/IRF3/ITPR3/CXCR4/MAPK14	1.15895336467978
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/394	88/9376	1.62251961236733	C1QB/SERPINE2/C1QA/C1QC/CD59/CLU	1.22879799712497
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/394	108/9376	1.54239518706524	POM121/IPO9/RANGAP1/NUP88/POM121C/SNUPN/NUP50	1.1873586380877
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/394	70/9376	1.69978245105149	PAK3/RAC1/FLCN/EP300/CREBBP	1.23077245149253
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/394	109/9376	1.52824477250501	SPP1/CD14/CCL4/RAC1/CCL5/IRF3/MAPK14	1.16178589418535
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/394	109/9376	1.52824477250501	PDPK1/PRKCE/NR1H2/CPT1A/IRS2/PRKAA1/PTPA	1.16178589418535
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/394	110/9376	1.51435163820951	SIN3A/EMP3/SMAD5/CHRD/EP300/BMP4/CREBBP	1.13646887446538
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/394	298/9376	1.27768882226689	TNFSF10/EBI3/CCL4/PRL/IL1RL1/CCL18/CCL5/CSH1/PRLR/TNFRSF8/CXCL14/CCL21/BMP4/EPOR/CXCR4/CSF2RB	1.02027833589484
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/394	19/9376	2.5049425594443	LIAS/PDHB	1.37523093697573
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/394	193/9376	1.35630309565766	CCL4/RAC1/CCL18/CCL5/CXCL14/CCL21/BCAR1/PXN/SHC1/NFKBIB/CXCR4	1.04749795005898
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/394	36/9376	1.98307952622673	GALNT15/GALNT6/C1GALT1	1.23769514543205
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/394	93/9376	1.53528737514328	ACTB/MYL9/RAC1/PDCD10/EP300/CREBBP	1.0865044849811
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/394	55/9376	1.73068758652515	HEXB/PSAP/ACER3/GLB1	1.13822742052913
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/394	56/9376	1.69978245105149	PTCH1/CSNK1E/MOSMO/SPOP	1.1000092274036
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/394	157/9376	1.36415661676744	C1QB/C1QA/C1QC/RAC1/BCAR1/NR1H2/CPT1A/EPOR/MAPK14	0.963703304152865
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/394	21/9376	2.26637660140198	CHST3/B3GALT6	1.21674018812793
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/394	21/9376	2.26637660140198	PANK3/PANK2	1.21674018812793
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/394	117/9376	1.42374940344484	ACTB/SS18/BAZ2A/SMARCD2/SMARCC1/TRRAP/DPF2	0.965977948500911
Genetic Information Processing	Transcription	hsa03040	Spliceosome	13/394	243/9376	1.27308809091099	U2AF2/DDX23/DHX8/PRPF3/PRPF8/SNRNP200/RBMX2/SART1/DDX42/DDX46/SRSF8/PRPF19/EFTUD2	0.903329915875047
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/394	201/9376	1.30232088289517	FLT1/HPGD/CD14/IGFBP3/PML/SS18/SIN3A/NUPR1/LDB1/ZBTB17/MLLT3	0.907424212494618
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/394	139/9376	1.36960888142278	KRT18/KRT19/FKBP5/CTSD/SHC1/ITPR3/NCOA2/NCOA3	0.919457268859287
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/394	120/9376	1.38815566835871	RAC1/PDPK1/SHC1/ARHGDIB/NFKBIB/IRAK3/MAPK14	0.89625606275398
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/394	205/9376	1.27690974371673	HLA-G/RAC1/HLA-E/TRADD/PXN/IRF3/EP300/DNAJA3/CREBBP/SND1/VAC14	0.839564458571347
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/394	60/9376	1.58646362098139	HSPB1/RAC1/PXN/MAPK14	0.954441218493367
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/394	23/9376	2.06930037519311	B4GAT1/ST3GAL3	1.0753142319425
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/394	23/9376	2.06930037519311	POLD2/MSH2	1.0753142319425
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/394	61/9376	1.56045602063743	FTL/FTH1/HMOX2/SLC31A1	0.919734019246817
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/394	144/9376	1.32205301748449	PSMA7/PSMD13/PUM2/PSMD14/ATXN10/ITPR3/ATXN3/ATG14	0.815657707798512
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/394	187/9376	1.27256440185673	CCL5/OAS3/GABARAP/IRF3/ATG12/CYBB/ITPR3/NFKBIB/CARD16/MAPK14	0.788502429204439
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/394	103/9376	1.38623034843034	C1QB/C1QA/C1QC/CCL5/GNA11/MAPK14	0.825471535324323
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/394	232/9376	1.23087694731315	FN1/ACTB/MYL9/RGCC/PAK3/RAC1/BCAR1/PXN/ABI2/CXCR4/MRAS/EZR	0.745767887714659
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/394	63/9376	1.51091773426799	PLOD1/KMT2B/PHYKPL/NSD3	0.852164963937169
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/394	63/9376	1.51091773426799	CUL4B/CUL4A/MNAT1/POLD2	0.852164963937169
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/394	63/9376	1.51091773426799	PTCH1/BMP4/WNT5B/DVL3	0.852164963937169
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/394	44/9376	1.62251961236733	DCTN4/ARHGDIB/STX4	0.866840582466664
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/394	480/9376	1.14027072758037	PSMA7/UBA52/RAC1/PSMD13/NDUFV3/RPS27A/CSNK1E/DCTN4/ZFYVE1/COX4I1/PSMD14/CYBB/ITPR3/ATXN3/UBE2J2/ACTR1B/ATG14/WNT5B/UBE2G2/NDUFA13/MAPK14/DVL3/NDUFB6	0.660750506916433
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	18/394	368/9376	1.16398146104613	ACTB/PSMA7/RAC1/PSMD13/NDUFV3/DCTN4/POM121/COX4I1/PSMD14/ITPR3/NUP88/POM121C/ACTR1B/ATG14/NDUFA13/MAPK14/NUP50/NDUFB6	0.672127548058986
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/394	107/9376	1.33440865316191	CPT1A/EP300/ITPR3/PDHB/CREBBP/PRKAA1	0.728618473536825
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/394	194/9376	1.22664712962478	ACTB/MYL9/TPM1/MYL6/MYO9A/DCTN4/TUBE1/ACTR1B/TUBG2/KIF1B	0.668081841552986
NA	NA	hsa04382	Cornified envelope formation	11/394	217/9376	1.20629722332686	KRT8/KRT18/KRT7/S100A10/S100A9/KRT19/CLDN12/CLDN5/COL17A1/PPP2R3C/PPP2R5D	0.643941542780942
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/394	46/9376	1.55197528139484	FTL/FTH1/HMOX2	0.785968149828044
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/394	46/9376	1.55197528139484	PSMA7/PSMD13/PSMD14	0.785968149828044
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	15/394	308/9376	1.15894258026238	PSMA7/PSMD13/NDUFV3/DCTN4/COX4I1/SIN3A/PSMD14/EP300/ACTR1B/ATG14/CREBBP/NDUFA13/RCOR1/AP2A1/NDUFB6	0.594028231189995
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/394	110/9376	1.29801568989386	FLT1/GAPDH/CYBB/EP300/PDHB/CREBBP	0.658470840776728
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	16/394	333/9376	1.14339720431091	FN1/SPP1/HLA-G/HLA-E/MAGI1/ATP6V1H/TRADD/PXN/IRF3/EP300/PPP2R3C/WNT5B/TUBG2/CREBBP/PPP2R5D/DVL3	0.558025132729048
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/394	133/9376	1.25247127972215	TNFSF10/TYROBP/HLA-G/RAC1/HLA-E/SHC1/FCGR3A	0.61415578796681
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/394	48/9376	1.48730964467005	IVD/PCCA/ACSF3	0.708889560286811
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/394	28/9376	1.69978245105149	B4GALT4/ST3GAL3	0.776658205037263
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/394	134/9376	1.24312447912721	MYL9/CALD1/MYL6/GNA11/PRKCE/PLA2G12A/ITPR3	0.593670308731573
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/394	71/9376	1.34067348251948	PRL/PRLR/SHC1/MAPK14	0.603471187172035
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/394	71/9376	1.34067348251948	RAC1/CCL5/ATP6V1H/MAPK14	0.603471187172035
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/394	138/9376	1.20709188552932	FN1/ACTB/RAC1/BCAR1/PXN/IRF3/MAPK14	0.513287715328959
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/394	30/9376	1.58646362098139	PIGS/DPM2	0.673807809609892
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/394	51/9376	1.3998208420424	CEPT1/LPCAT1/PLA2G12A	0.599616149245021
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/394	184/9376	1.16398146104613	MYL9/PAK3/RAC1/PTCH1/PDPK1/PLXNB2/WNT5B/CXCR4/ABLIM3	0.470485105284131
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/394	52/9376	1.37290121046466	APOE/NPC2/OSBPL5	0.564730906335674
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/394	142/9376	1.17308929720455	ACTB/RAC1/CAV1/CTSL/BMP4/PRKAA1/MAPK14	0.435277957877708
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/394	32/9376	1.48730964467005	GLB1/GANC	0.578310136911824
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/394	32/9376	1.48730964467005	GABARAP/ATG12	0.578310136911824
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/394	98/9376	1.21413032217963	PI4KA/PI4K2A/ITPR3/PIK3C2A/MTMR3	0.446283929072745
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/394	98/9376	1.21413032217963	RAC1/PRKCE/DNM2/FCGR3A/ASAP3	0.446283929072745
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/394	54/9376	1.32205301748449	CISD1/MTAP/SDSL	0.497069283908972
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/394	122/9376	1.17034201547807	PAK3/PDPK1/PPP2R3C/NFKBIB/MAPK14/PPP2R5D	0.396628733332228
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/394	78/9376	1.22035663152414	PI4KA/PI4K2A/PIK3C2A/MTMR3	0.409285047812797
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/394	101/9376	1.17806704528321	FN1/RAC1/PRKCE/CYBB/MAPK14	0.376820484721117
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/394	56/9376	1.27483683828861	ALG3/MAN1B1/DPM2	0.432024349415508
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/394	34/9376	1.3998208420424	CSNK1E/PRKAA1	0.489138874897522
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/394	13/9376	1.83053494728622	FEN1	0.627580295947336
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/394	57/9376	1.25247127972215	CPT1A/HSD17B12/ACSF3	0.400416510994282
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/394	35/9376	1.35982596084119	MPI/ENOSF1	0.446659991829213
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/394	103/9376	1.15519195702528	CPSF7/DAZAP1/PPP2R3C/PPP2R5D/WDR82	0.33168430071919
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/394	174/9376	1.09411284205613	DNAJC10/SEC24C/NPLOC4/AMFR/ATXN3/UBE2J2/MAN1B1/UBE2G2	0.262439754023524
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/394	36/9376	1.32205301748449	POLD2/FEN1	0.405464100999255
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/394	268/9376	1.06553526782332	PSMA7/UBA52/PSMD13/NDUFV3/RPS27A/COX4I1/PSMD14/ITPR3/UBE2J2/UBE2G2/NDUFA13/NDUFB6	0.227970256772627
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/394	83/9376	1.14684117179377	EP300/L3MBTL2/ASXL2/CREBBP	0.281420767341293
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/394	83/9376	1.14684117179377	CCL4/CCL5/IRF3/NFKBIB	0.281420767341293
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/394	388/9376	1.04265006018107	GAPDH/APOE/PSMA7/PSMD13/NDUFV3/CSNK1E/COX4I1/PSMD14/PSENEN/IRS2/CYBB/ITPR3/ATG14/WNT5B/NDUFA13/DVL3/NDUFB6	0.179701293412579
NA	NA	hsa04518	Integrin signaling	7/394	154/9376	1.08167974157822	FN1/FLT1/SPP1/ACTB/FERMT2/RAC1/PXN	0.214047115801973
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/394	154/9376	1.08167974157822	ACTB/MYL9/MYL6/CACNB2/EEF2/ITPR3/PRKAA1	0.214047115801973
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/394	178/9376	1.06952603661667	NOTUM/RAC1/CSNK1E/EP300/CBY1/WNT5B/CREBBP/DVL3	0.196136307575618
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/394	38/9376	1.25247127972215	HEXB/MPI	0.32660593221289
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/394	38/9376	1.25247127972215	UNG/RFXANK	0.32660593221289
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/394	62/9376	1.15146553135746	CLPB/IRS2/PRKAA1	0.250604441875567
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/394	157/9376	1.06101070193023	ACTB/STK3/CSNK1E/BMP4/WNT5B/LATS1/DVL3	0.161458593175571
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/394	16/9376	1.48730964467005	MIF	0.408577359675084
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/394	16/9376	1.48730964467005	HEXB	0.408577359675084
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/394	63/9376	1.13318830070099	HPGD/GPX4/PLA2G12A	0.222146141836956
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/394	158/9376	1.05429544432307	ORC3/WAPL/CDKN1C/EP300/CREBBP/ZBTB17/PPP2R5D	0.144152044662257
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/394	158/9376	1.05429544432307	FLCN/ATP6V1H/PDPK1/LPIN2/WNT5B/PRKAA1/DVL3	0.144152044662257
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/394	87/9376	1.09411284205613	TPM1/CACNB2/COX4I1/ASPH	0.184701855022994
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/394	65/9376	1.09832096837173	SPP1/GNA11/ITPR3	0.166591134601578
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/394	235/9376	1.01263635381791	ACTB/NDUFV3/SMARCD2/COX4I1/SMARCC1/CPT1A/NDUFA13/PRKAA1/MAPK14/NDUFB6	0.0410871557223403
NA	NA	hsa04519	Cadherin signaling	17/394	404/9376	1.00135698849073	KRT8/KRT18/KRT7/ACTB/KRT19/STK3/RAC1/PCDHGA10/PSENEN/EP300/ABI2/WNT5B/CREBBP/MRAS/LATS1/MAPK14/DVL3	0.00583941630348844
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/394	18/9376	1.32205301748449	ACSF3	0.286430544457913
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/394	67/9376	1.06553526782332	GAPDH/ADPGK/PDHB	0.112747829108039
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/394	67/9376	1.06553526782332	EP300/ITPR3/CREBBP	0.112747829108039
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/394	116/9376	1.02573078942762	GAPDH/ADPGK/PCCA/PDHB/SDSL	0.0584014776659902
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/394	142/9376	1.00550511188961	TYROBP/RAC1/ITPR3/ACP5/FCGR3A/MAPK14	0.0138440325306003
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/394	44/9376	1.08167974157822	TAF1/MNAT1	0.113736681316975
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/394	216/9376	0.991539763113367	TNFSF10/CD14/RAC1/CCL5/PDPK1/IRF3/CYBB/MAPK14/MIB2	-0.0263456480581223
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/394	69/9376	1.03465018759656	RAC1/PDPK1/MAPK14	0.0605023860506918
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/394	168/9376	0.991539763113367	PRL/CSH1/PRLR/EP300/EPOR/CREBBP/CSF2RB	-0.0231740389597091
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/394	45/9376	1.05764241398759	ABCD3/ABCB8	0.0811767287375404
NA	NA	hsa04081	Hormone signaling	9/394	219/9376	0.977957026632362	PRL/NPR3/CSH1/PRLR/SMAD5/GNA11/IRS2/EPOR/ADIPOR2	-0.0691294099513311
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/394	20/9376	1.18984771573604	SC5D	0.178001020039388
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/394	47/9376	1.01263635381791	PRKCE/IRS2	0.0181886465582988
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/394	99/9376	0.961493103625083	CARM1/SHC1/MAPK14/NCOA3	-0.0806676785452096
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/394	99/9376	0.961493103625083	ACTB/TPM1/CACNB2/PRKAA1	-0.0806676785452096
NA	NA	hsa04517	IgSF CAM signaling	12/394	299/9376	0.955061711627591	ACTB/MYL9/MYL6/PAK3/RAC1/MAGI1/BCAR1/PDPK1/PXN/LRFN4/EZR/MAPK14	-0.16539720909164
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/394	22/9376	1.08167974157822	AOC1	0.0803293469691219
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/394	75/9376	0.951878172588833	PDPK1/SLC31A1/MSH2	-0.0876304706913213
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/394	101/9376	0.942453636226567	EP300/WNT5B/CREBBP/DVL3	-0.121778000283849
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/394	76/9376	0.939353459791611	ACTB/ITPR3/EZR	-0.111177927941051
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/394	23/9376	1.03465018759656	LNPEP	0.0348450638627395
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/394	154/9376	0.927154064209902	PANK3/LIAS/MPI/PANK2/FLAD1/NME7	-0.19089754879837
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/394	103/9376	0.924153565620226	FN1/CD14/HSPB1/GNA11	-0.162102933885943
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/394	51/9376	0.933213894694934	ACTB/ATP6V1H	-0.100159929336174
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/394	104/9376	0.915267473643108	CEPT1/LPCAT1/PLA2G12A/LPIN2	-0.18198154059458
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/394	24/9376	0.991539763113367	B3GALT6	-0.00869126754262359
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/394	105/9376	0.906550640560793	CD14/CCL4/CCL21/TRADD	-0.201676321578915
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/394	79/9376	0.903681809419778	ATP6V1H/DNM2/AP2A1	-0.180051883699229
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/394	157/9376	0.909437744511623	HLA-G/IGFBP3/HLA-E/ITPR3/MRAS/MAPK14	-0.239663762313076
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/394	106/9376	0.8979982760272	FOLR2/PDPK1/EP300/CREBBP	-0.221191177881115
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/394	53/9376	0.8979982760272	DNM2/AP2A1	-0.155960575274072
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/394	212/9376	0.8979982760272	FLT1/ACTB/RAC1/MAGI1/RALB/BCAR1/MRAS/MAPK14	-0.314615507961624
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/394	26/9376	0.915267473643108	PLA2G12A	-0.0906104417432123
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/394	136/9376	0.8748880262765	OAS3/RCHY1/TRADD/IRF3/NFKBIB	-0.307807762352141
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/394	83/9376	0.860130878845331	DHRS4/PRDX5/ABCD3	-0.268058848358824
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/394	27/9376	0.881368678322993	HSD17B12	-0.129284331716508
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/394	138/9376	0.862208489663798	NDUFV3/COX4I1/ATP6V1H/NDUFA13/NDUFB6	-0.341523229417811
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/394	138/9376	0.862208489663798	PDPK1/SHC1/IRS2/PRKAA1/EXOC7	-0.341523229417811
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/394	28/9376	0.849891225525743	HSD17B12	-0.166599221184159
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/394	140/9376	0.849891225525743	SPP1/PRKCE/ITPR3/MRAS/PRKAA1	-0.374779095514001
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/394	87/9376	0.820584631542097	RAC1/RALB/MSH2	-0.352112959823749
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/394	168/9376	0.849891225525743	FTL/TNFSF10/FTH1/TRADD/CYBB/CHMP1B	-0.411173662685122
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/394	59/9376	0.806676417448163	NME7/UCKL1	-0.311975160231
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/394	59/9376	0.806676417448163	GPX4/LANCL1	-0.311975160231
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/394	60/9376	0.793231810490694	GNA11/ITPR3	-0.336505242065463
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/394	30/9376	0.793231810490694	PDHB	-0.237562938067884
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/394	30/9376	0.793231810490694	PLA2G12A	-0.237562938067884
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/394	30/9376	0.793231810490694	FOLR2	-0.237562938067884
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/394	170/9376	0.83989250522544	ACTB/SMARCD2/SMARCC1/SHC1/WNT5B/DVL3	-0.44121255416786
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/394	89/9376	0.802144527462499	FN1/SPP1/HSPG2	-0.392782899126626
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/394	144/9376	0.826283135927806	SMAD5/BMP4/WNT5B/MAPK14/DVL3	-0.439969481614609
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/394	90/9376	0.793231810490694	IRS2/ADIPOR2/PRKAA1	-0.412798265527771
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/394	31/9376	0.767643687571639	PCCA	-0.271389407752509
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/394	31/9376	0.767643687571639	OXA1L	-0.271389407752509
NA	NA	hsa04981	Folate transport and metabolism	1/394	31/9376	0.767643687571639	FOLR2	-0.271389407752509
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/394	119/9376	0.799897624024229	CCL5/TRADD/ITCH/MAPK14	-0.460084728414681
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/394	32/9376	0.743654822335025	PCCA	-0.304215228271324
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/394	93/9376	0.767643687571639	GNA11/ITPR3/MAPK14	-0.471627367448207
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/394	149/9376	0.798555513916806	NDUFV3/ITPR3/NDUFA13/MAPK14/NDUFB6	-0.519117275787116
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/394	33/9376	0.721119827718812	PDHB	-0.336107851180209
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/394	362/9376	0.854586757158482	FN1/FLT1/SPP1/PRL/RAC1/MAGI1/CSH1/PRLR/PDPK1/PPP2R3C/EPOR/PRKAA1/PPP2R5D	-0.590944495749339
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/394	94/9376	0.75947726536343	S100A9/TRADD/MAPK14	-0.490847407401841
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/394	65/9376	0.732213978914486	GNA11/ITPR3	-0.453725973430351
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/394	34/9376	0.6999104210212	POLR1E	-0.367128132391344
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/394	154/9376	0.772628386841585	TPM1/CACNB2/PPP2R3C/MAPK14/PPP2R5D	-0.595842213398712
Organismal Systems	Immune system	hsa04611	Platelet activation	4/394	126/9376	0.755458867133994	ACTB/VAMP8/ITPR3/MAPK14	-0.578780045667483
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/394	68/9376	0.6999104210212	CD14/PML	-0.520144974743604
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/394	98/9376	0.72847819330778	GNA11/PRKCE/ITPR3	-0.565897522060797
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/394	36/9376	0.661026508742245	FGGY	-0.426766943433541
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/394	36/9376	0.661026508742245	GANC	-0.426766943433541
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/394	156/9376	0.76272289470259	CLDN12/CLDN5/OAS3/TRADD/IRF3	-0.62589271672973
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/394	99/9376	0.721119827718812	PRKCE/ITPR3/MAPK14	-0.58422304075552
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/394	37/9376	0.643160927424887	MIF	-0.45548103627186
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/394	37/9376	0.643160927424887	MPI	-0.45548103627186
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/394	37/9376	0.643160927424887	HBB	-0.45548103627186
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/394	38/9376	0.626235639861074	SIRT7	-0.483515025572311
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/394	38/9376	0.626235639861074	PDPK1	-0.483515025572311
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/394	71/9376	0.670336741259741	SLC16A3/PDHB	-0.583967606306454
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/394	102/9376	0.6999104210212	RAC1/PLA2G12A/ITPR3	-0.638211577211171
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/394	133/9376	0.715697874126942	PPP2R3C/ITPR3/MAPK14/PPP2R5D	-0.691586767129972
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/394	163/9376	0.729967923764442	IRF3/EP300/HSPG2/CREBBP/MAPK14	-0.728376366756658
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/394	105/9376	0.679912980420595	ITPR3/MRAS/MAPK14	-0.690790959738229
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/394	105/9376	0.679912980420595	ACTB/TPM1/CACNB2	-0.690790959738229
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/394	41/9376	0.580413519871239	SDSL	-0.563901794864092
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/394	41/9376	0.580413519871239	POLD2	-0.563901794864092
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/394	75/9376	0.634585448392555	GAPDH/SDSL	-0.665424629061103
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/394	75/9376	0.634585448392555	IGFBP3/RCHY1	-0.665424629061103
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/394	166/9376	0.716775732371109	MYL9/GNA11/PRKCE/IRS2/ITPR3	-0.771084396862551
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/394	76/9376	0.626235639861074	PDPK1/CPT1A	-0.685189080130088
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/394	42/9376	0.566594150350495	AOC1	-0.589566419923903
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/394	77/9376	0.618102709473268	RAC1/RALB	-0.704727209053075
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/394	43/9376	0.55341754220281	CPT1A	-0.614713113890888
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/394	43/9376	0.55341754220281	PLA2G12A	-0.614713113890888
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/394	227/9376	0.733826785035444	RAC1/NDUFV3/COX4I1/PDPK1/NDUFA13/MAPK14/NDUFB6	-0.850232474562925
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/394	82/9376	0.580413519871239	NME7/UCKL1	-0.799234645964365
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/394	47/9376	0.506318176908953	PDHB	-0.710600883914388
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/394	148/9376	0.643160927424887	SHC1/WNT5B/NCOA3/DVL3	-0.916424498401829
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/394	149/9376	0.638844411133445	RALB/SHC1/DNM2/MRAS	-0.930688692815697
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/394	85/9376	0.55992833681696	NME7/UCKL1	-0.853589101050596
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/394	238/9376	0.6999104210212	FLT1/PAK3/RAC1/RALB/SHC1/PLA2G12A/MRAS	-0.98211204998517
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/394	86/9376	0.55341754220281	PAK3/SHC1	-0.871345217647169
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/394	86/9376	0.55341754220281	GNA11/ITPR3	-0.871345217647169
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/394	86/9376	0.55341754220281	ACTB/CACNB2	-0.871345217647169
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/394	50/9376	0.475939086294416	AOC1	-0.778155318453919
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/394	50/9376	0.475939086294416	HBB	-0.778155318453919
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	9/394	300/9376	0.713908629441624	FLT1/CD14/STK3/HSPB1/RAC1/CACNB2/TRADD/MRAS/MAPK14	-1.05478845044431
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/394	89/9376	0.534763018308333	GNA11/ITPR3	-0.923588961711125
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/394	155/9376	0.614114950057311	GNA11/ITPR3/WNT5B/DVL3	-1.01456999703752
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/394	90/9376	0.528821206993796	NFKBIB/MAPK14	-0.940675589257773
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/394	91/9376	0.523009984938919	RAC1/NFKBIB	-0.957604666634559
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/394	54/9376	0.440684339161497	POLI	-0.86326977211278
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/394	93/9376	0.511762458381093	LYZ/ITPR3	-0.99100465159131
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/394	93/9376	0.511762458381093	FN1/ZBTB17	-0.99100465159131
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/394	56/9376	0.424945612762872	CD14	-0.903945406560681
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/394	195/9376	0.610178315762072	ACTB/RAC1/CYBB/FCGR3A/MAPK14	-1.15208767152969
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/394	226/9376	0.631777548178429	MYL9/FXYD1/RAC1/PTCH1/EP300/CREBBP	-1.17354882171306
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/394	59/9376	0.403338208724082	IRS2	-0.962860585759672
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/394	59/9376	0.403338208724082	PDPK1	-0.962860585759672
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/394	99/9376	0.480746551812542	RAC1/PDPK1	-1.08777840296583
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/394	138/9376	0.517325093798279	ITPR3/MAPK14/PPP2R5D	-1.19633417416458
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/394	103/9376	0.462076782810113	COL17A1/SLC36A4	-1.14967740309621
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/394	65/9376	0.366106989457243	LPIN2	-1.07404308146228
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/394	66/9376	0.360559913859406	HSD17B12	-1.09180281445084
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/394	68/9376	0.3499552105106	DHRS4	-1.12672200001674
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/394	69/9376	0.344883395865519	ITPR3	-1.14389330739153
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/394	183/9376	0.520152006879143	EMG1/WDR43/LSG1/IMP4	-1.37292818672182
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/394	150/9376	0.475939086294416	SHC1/WNT5B/DVL3	-1.35508924325831
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/394	73/9376	0.325985675544121	PDPK1	-1.21078287502014
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/394	115/9376	0.413860075038623	GNA11/ITPR3	-1.32455045513952
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/394	115/9376	0.413860075038623	GNA11/ITPR3	-1.32455045513952
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/394	75/9376	0.317292724196278	ITPR3	-1.24321878743089
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/394	76/9376	0.313117819930537	SHC1	-1.25920023231912
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/394	77/9376	0.309051354736634	SHC1	-1.27502949733908
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/394	323/9376	0.589398249281011	TIMP3/TPM1/PRKCE/SHC1/IRS2/EP300/CREBBP/EZR	-1.5727982653716
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/394	80/9376	0.29746192893401	SHC1	-1.32164258488021
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/394	233/9376	0.510664255680704	FN1/ACTB/MYL9/TPM1/HSPG2	-1.58411886171774
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/394	128/9376	0.371827411167513	NUDT5/NME7	-1.49867436763861
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/394	130/9376	0.366106989457243	SHC1/MAPK14	-1.52425601854334
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/394	86/9376	0.276708771101405	ITPR3	-1.41124296815337
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/394	89/9376	0.267381509154166	GABARAP	-1.45439502429562
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/394	254/9376	0.468443982573244	FLT1/GNA11/ASPH/ITPR3/CXCR4	-1.79873873467092
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/394	97/9376	0.245329425924957	ITPR3	-1.56473184011378
NA	NA	hsa04082	Neuroactive ligand signaling	3/394	199/9376	0.358748054995791	TAC3/OGFRL1/GNA11	-1.91492642176643
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/394	110/9376	0.216335948315644	MAPK14	-1.73151932766652
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/394	115/9376	0.206930037519311	ITPR3	-1.79216793640272
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/394	116/9376	0.205146157885524	ITPR3	-1.80408918422627
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/394	370/9376	0.385896556454932	NPW/PRL/TAC3/CSH1/PRLR/OGFRL1	-2.52419933006285
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/394	191/9376	0.124591383846706	SHC1	-2.55997157957734