ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 37/755 175/18639 0.211428571428571 5.21962535477767 7.53891158545288e-17 7.24489403362022e-14 GO:0023026 MHC class II protein complex binding 9/755 27/18639 0.333333333333333 8.22913907284768 6.80096713562451e-07 0.000326786470866758 GO:0042605 peptide antigen binding 10/755 45/18639 0.222222222222222 5.48609271523179 9.86232261797271e-06 0.00301354505312229 GO:0023023 MHC protein complex binding 9/755 37/18639 0.243243243243243 6.0050474315375 1.25433717091459e-05 0.00301354505312229 GO:0140033 acetylation-dependent protein binding 7/755 24/18639 0.291666666666667 7.20049668874172 3.29170061221401e-05 0.00632664857667533 GO:0032182 ubiquitin-like protein binding 15/755 120/18639 0.125 3.08592715231788 0.00010232635367582 0.0163892709804105 GO:0070577 lysine-acetylated histone binding 6/755 23/18639 0.260869565217391 6.44019579614166 0.000241877392930205 0.032025465233044 GO:0019843 rRNA binding 10/755 65/18639 0.153846153846154 3.79806418746816 0.000266601167392666 0.032025465233044 GO:0032395 MHC class II receptor activity 4/755 10/18639 0.4 9.87496688741722 0.00046121054642771 0.0492470372352255 GO:0042277 peptide binding 22/755 249/18639 0.0883534136546185 2.18121758557408 0.000528432221957454 0.0507823365301113 GO:0140030 modification-dependent protein binding 17/755 173/18639 0.0982658959537572 2.42593117176435 0.000677623790984775 0.0529297095961895 GO:1990948 ubiquitin ligase inhibitor activity 4/755 11/18639 0.363636363636364 8.97724262492475 0.000701584844862522 0.0529297095961895 GO:0043130 ubiquitin binding 12/755 100/18639 0.12 2.96249006622517 0.000716010639698714 0.0529297095961895 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/755 12/18639 0.333333333333333 8.22913907284768 0.00101877459057 0.0699315986812691 GO:0009982 pseudouridine synthase activity 4/755 13/18639 0.307692307692308 7.59612837493632 0.00142464305350136 0.0912721316276535 GO:0003713 transcription coactivator activity 21/755 256/18639 0.08203125 2.02513969370861 0.00178499535967655 0.107211283790573 GO:0019787 ubiquitin-like protein transferase activity 33/755 479/18639 0.0688935281837161 1.70080327392885 0.00217679484255968 0.123052931982344 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/755 15/18639 0.266666666666667 6.58331125827814 0.00254946421147 0.136113061512371 GO:0004842 ubiquitin-protein transferase activity 31/755 449/18639 0.0690423162583519 1.70447646720453 0.00282622951434661 0.142947713857215 GO:0005484 SNAP receptor activity 6/755 36/18639 0.166666666666667 4.11456953642384 0.00298258281638204 0.143313104327157 GO:0034450 ubiquitin-ubiquitin ligase activity 4/755 16/18639 0.25 6.17185430463576 0.0032913728690608 0.150619491769878 GO:0050750 low-density lipoprotein particle receptor binding 5/755 26/18639 0.192307692307692 4.7475802343352 0.00348479135123271 0.15222202220612 GO:0016755 aminoacyltransferase activity 33/755 496/18639 0.0665322580645161 1.64250961333048 0.00374318525919159 0.156400044960136 GO:0140098 catalytic activity, acting on RNA 27/755 387/18639 0.0697674418604651 1.72237794547975 0.00445314753233465 0.161216702277501 GO:0036408 histone H3K14 acetyltransferase activity 5/755 28/18639 0.178571428571429 4.40846736045412 0.00487053317109685 0.161216702277501 GO:0000900 mRNA regulatory element binding translation repressor activity 4/755 18/18639 0.222222222222222 5.48609271523179 0.00518882885296217 0.161216702277501 GO:0140297 DNA-binding transcription factor binding 32/755 488/18639 0.0655737704918033 1.61884703072413 0.00527571441772925 0.161216702277501 GO:0010484 histone H3 acetyltransferase activity 5/755 29/18639 0.172413793103448 4.25645124457639 0.00569249306463327 0.161216702277501 GO:0042393 histone binding 19/755 247/18639 0.0769230769230769 1.89903209373408 0.0057775955032815 0.161216702277501 GO:0097177 mitochondrial ribosome binding 3/755 10/18639 0.3 7.40622516556291 0.00641590842613798 0.161216702277501 GO:0003712 transcription coregulator activity 32/755 495/18639 0.0646464646464646 1.59595424443107 0.00647298512837109 0.161216702277501 GO:0043175 RNA polymerase core enzyme binding 6/755 42/18639 0.142857142857143 3.52677388836329 0.00654421902667173 0.161216702277501 GO:0043995 histone H4K5 acetyltransferase activity 5/755 30/18639 0.166666666666667 4.11456953642384 0.00660754068904651 0.161216702277501 GO:0043996 histone H4K8 acetyltransferase activity 5/755 30/18639 0.166666666666667 4.11456953642384 0.00660754068904651 0.161216702277501 GO:0043997 histone H4K12 acetyltransferase activity 5/755 30/18639 0.166666666666667 4.11456953642384 0.00660754068904651 0.161216702277501 GO:0070566 adenylyltransferase activity 5/755 30/18639 0.166666666666667 4.11456953642384 0.00660754068904651 0.161216702277501 GO:0048156 tau protein binding 6/755 43/18639 0.13953488372093 3.44475589095949 0.00735086834314577 0.161216702277501 GO:0005096 GTPase activator activity 20/755 271/18639 0.0738007380073801 1.82194961022458 0.00736826301602947 0.161216702277501 GO:0070325 lipoprotein particle receptor binding 5/755 31/18639 0.161290322580645 3.98184148686178 0.00762081190547999 0.161216702277501 GO:0001223 transcription coactivator binding 6/755 44/18639 0.136363636363636 3.36646598434678 0.0082268909528437 0.161216702277501 GO:0008199 ferric iron binding 3/755 11/18639 0.272727272727273 6.73293196869356 0.00855877976911627 0.161216702277501 GO:0042608 T cell receptor binding 3/755 11/18639 0.272727272727273 6.73293196869356 0.00855877976911627 0.161216702277501 GO:0050998 nitric-oxide synthase binding 3/755 11/18639 0.272727272727273 6.73293196869356 0.00855877976911627 0.161216702277501 GO:0035613 RNA stem-loop binding 4/755 21/18639 0.19047619047619 4.70236518448439 0.00921798722512613 0.161216702277501 GO:0061659 ubiquitin-like protein ligase activity 25/755 372/18639 0.0672043010752688 1.65910061952574 0.00952425900986027 0.161216702277501 GO:0016922 nuclear receptor binding 12/755 137/18639 0.0875912408759124 2.16240150819355 0.00982012687579383 0.161216702277501 GO:0071889 14-3-3 protein binding 5/755 33/18639 0.151515151515152 3.74051776038531 0.00996186902693478 0.161216702277501 GO:0003684 damaged DNA binding 8/755 74/18639 0.108108108108108 2.66890996957222 0.00998133896563566 0.161216702277501 GO:0004540 RNA nuclease activity 11/755 121/18639 0.0909090909090909 2.24431065623119 0.010086934119947 0.161216702277501 GO:0001098 basal transcription machinery binding 7/755 60/18639 0.116666666666667 2.88019867549669 0.0104188291790229 0.161216702277501 GO:0001099 basal RNA polymerase II transcription machinery binding 7/755 60/18639 0.116666666666667 2.88019867549669 0.0104188291790229 0.161216702277501 GO:0032931 histone H3K56 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0043992 histone H3K9 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0043993 histone H3K18 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0043994 histone H3K23 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0043999 histone H2AK5 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044012 histone H2AK9 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044014 histone H2BK5 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044015 histone H2BK12 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044016 histone H3K4 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044017 histone H3K27 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0044018 histone H3K36 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0046972 histone H4K16 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0140908 histone H3K122 acetyltransferase activity 4/755 22/18639 0.181818181818182 4.48862131246237 0.0109120014633286 0.161216702277501 GO:0140375 immune receptor activity 13/755 156/18639 0.0833333333333333 2.05728476821192 0.0109848914022563 0.161216702277501 GO:1990817 poly(A) RNA polymerase activity 3/755 12/18639 0.25 6.17185430463576 0.0110721148286317 0.161216702277501 GO:0031625 ubiquitin protein ligase binding 21/755 302/18639 0.0695364238410596 1.71667470724968 0.0116512453417525 0.167117116021256 GO:0035091 phosphatidylinositol binding 20/755 284/18639 0.0704225352112676 1.7385505083481 0.0119745091937277 0.168252716456355 GO:0044389 ubiquitin-like protein ligase binding 22/755 322/18639 0.0683229813664596 1.68671794660853 0.0120805800577404 0.168252716456355 GO:0010485 histone H4 acetyltransferase activity 5/755 35/18639 0.142857142857143 3.52677388836329 0.0127536731785706 0.170769248207489 GO:0061631 ubiquitin conjugating enzyme activity 5/755 35/18639 0.142857142857143 3.52677388836329 0.0127536731785706 0.170769248207489 GO:0044013 histone H2B acetyltransferase activity 4/755 23/18639 0.173913043478261 4.29346386409444 0.0127943661508212 0.170769248207489 GO:0000993 RNA polymerase II complex binding 5/755 36/18639 0.138888888888889 3.42880794701987 0.0143296554950526 0.186091877442507 GO:0055106 ubiquitin-protein transferase regulator activity 5/755 36/18639 0.138888888888889 3.42880794701987 0.0143296554950526 0.186091877442507 GO:0043998 histone H2A acetyltransferase activity 4/755 24/18639 0.166666666666667 4.11456953642384 0.0148717572076199 0.190556782353636 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/755 25/18639 0.16 3.94998675496689 0.0171501357096667 0.216858952855128 GO:0061630 ubiquitin protein ligase activity 23/755 353/18639 0.0651558073654391 1.60852860064162 0.0174804603244933 0.218165225608286 GO:0017124 SH3 domain binding 10/755 115/18639 0.0869565217391304 2.14673193204722 0.0183619195510384 0.225942812350194 GO:1901981 phosphatidylinositol phosphate binding 14/755 185/18639 0.0756756756756757 1.86823697870056 0.0185738628258744 0.225942812350194 GO:0008198 ferrous iron binding 4/755 26/18639 0.153846153846154 3.79806418746816 0.0196347437748366 0.235862359595224 GO:0031386 protein tag activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.240597048706019 GO:0061578 K63-linked deubiquitinase activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.240597048706019 GO:0141047 molecular tag activity 3/755 15/18639 0.2 4.93748344370861 0.0209235424547825 0.240597048706019 GO:0140597 protein carrier chaperone 14/755 188/18639 0.074468085106383 1.83842468648725 0.0210303351626489 0.240597048706019 GO:0002039 p53 binding 7/755 69/18639 0.101449275362319 2.50452058738843 0.0213532750264688 0.241417615299253 GO:0140313 molecular sequestering activity 6/755 55/18639 0.109090909090909 2.69317278747742 0.0232909980063763 0.260263361443345 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/755 41/18639 0.121951219512195 3.01066063640769 0.0241647435194751 0.266923201404777 GO:0003823 antigen binding 13/755 174/18639 0.0747126436781609 1.8444622059831 0.0249650110495678 0.269507480640425 GO:0008142 oxysterol binding 3/755 16/18639 0.1875 4.62889072847682 0.0249925046668721 0.269507480640425 GO:0016866 intramolecular transferase activity 4/755 28/18639 0.142857142857143 3.52677388836329 0.0252400346073239 0.269507480640425 GO:0004402 histone acetyltransferase activity 5/755 42/18639 0.119047619047619 2.93897824030274 0.026545895477962 0.277289190807842 GO:0008307 structural constituent of muscle 5/755 42/18639 0.119047619047619 2.93897824030274 0.026545895477962 0.277289190807842 GO:0016504 peptidase activator activity 6/755 57/18639 0.105263157894737 2.59867549668874 0.0272603631369755 0.280838149777378 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 22/755 349/18639 0.0630372492836676 1.55622687337521 0.0274701207898788 0.280838149777378 GO:0000149 SNARE binding 9/755 106/18639 0.0849056603773585 2.09610146195177 0.0281132071636594 0.282282410715618 GO:0043021 ribonucleoprotein complex binding 13/755 177/18639 0.0734463276836158 1.81320013469525 0.0281988672515082 0.282282410715618 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/755 17/18639 0.176470588235294 4.35660303856642 0.0294549695876538 0.288839038507503 GO:0032183 SUMO binding 3/755 17/18639 0.176470588235294 4.35660303856642 0.0294549695876538 0.288839038507503 GO:0045296 cadherin binding 21/755 334/18639 0.062874251497006 1.55220287901019 0.0314518856358972 0.301766835852466 GO:0070063 RNA polymerase binding 6/755 59/18639 0.101694915254237 2.51058480188573 0.031652975300774 0.301766835852466 GO:0001968 fibronectin binding 4/755 30/18639 0.133333333333333 3.29165562913907 0.0317153490334017 0.301766835852466 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/755 60/18639 0.1 2.4687417218543 0.0340123248698575 0.32044945294052 GO:0008009 chemokine activity 5/755 45/18639 0.111111111111111 2.74304635761589 0.0345650169657071 0.322494964116937 GO:0003724 RNA helicase activity 7/755 77/18639 0.0909090909090909 2.24431065623119 0.0362126454992975 0.333900807161787 GO:0019905 syntaxin binding 6/755 61/18639 0.0983606557377049 2.4282705460862 0.0364823982851068 0.333900807161787 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/755 130/18639 0.0769230769230769 1.89903209373408 0.0385889275000261 0.34984867290118 GO:0061733 protein-lysine-acetyltransferase activity 5/755 47/18639 0.106382978723404 2.62632098069607 0.0406595370850478 0.360361740582272 GO:0008186 ATP-dependent activity, acting on RNA 7/755 79/18639 0.0886075949367089 2.18749266493419 0.0407800109620134 0.360361740582272 GO:0004896 cytokine receptor activity 8/755 96/18639 0.0833333333333333 2.05728476821192 0.0408734960702057 0.360361740582272 GO:0140311 protein sequestering activity 4/755 33/18639 0.121212121212121 2.99241420830825 0.0430933635720908 0.376479294479812 GO:0032266 phosphatidylinositol-3-phosphate binding 5/755 48/18639 0.104166666666667 2.5716059602649 0.043935471599725 0.38037827213816 GO:0016004 phospholipase activator activity 3/755 20/18639 0.15 3.70311258278146 0.0451668744821779 0.387547914083688 GO:0140104 molecular carrier activity 16/755 249/18639 0.0642570281124498 1.5863400622357 0.0470008040844017 0.399005428723244 GO:0030332 cyclin binding 4/755 34/18639 0.117647058823529 2.90440202571095 0.0473325898797605 0.399005428723244 GO:0000287 magnesium ion binding 15/755 230/18639 0.0652173913043478 1.61004894903542 0.0478955110043029 0.400239878914218 GO:0001540 amyloid-beta binding 7/755 83/18639 0.0843373493975904 2.08207133168435 0.0509989300188566 0.420198118117186 GO:0072542 protein phosphatase activator activity 3/755 21/18639 0.142857142857143 3.52677388836329 0.0511583556916865 0.420198118117186 GO:0000175 3'-5'-RNA exonuclease activity 4/755 35/18639 0.114285714285714 2.82141911069063 0.0517943855831399 0.42181698767286 GO:0051117 ATPase binding 7/755 84/18639 0.0833333333333333 2.05728476821192 0.0537840256821478 0.43329539459195 GO:0005125 cytokine activity 15/755 234/18639 0.0641025641025641 1.5825267447784 0.0541055643611176 0.43329539459195 GO:0032934 sterol binding 6/755 68/18639 0.0882352941176471 2.17830151928321 0.0569674353963698 0.452443846412491 GO:0061133 endopeptidase activator activity 3/755 22/18639 0.136363636363636 3.36646598434678 0.0575130432014273 0.453033069807964 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.453271051780063 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.453271051780063 GO:0045322 unmethylated CpG binding 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.453271051780063 GO:0051864 histone H3K36 demethylase activity 2/755 10/18639 0.2 4.93748344370861 0.0594299193801124 0.453271051780063 GO:0034212 protein N-acetyltransferase activity 5/755 53/18639 0.0943396226415094 2.32900162439085 0.0626266802879881 0.470354379758291 GO:0016853 isomerase activity 12/755 180/18639 0.0666666666666667 1.64582781456954 0.0626486582820616 0.470354379758291 GO:0005158 insulin receptor binding 3/755 23/18639 0.130434782608696 3.22009789807083 0.0642208447590182 0.478420401654391 GO:0004197 cysteine-type endopeptidase activity 7/755 88/18639 0.0795454545454545 1.96377182420229 0.0658615302619726 0.486868696782736 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/755 38/18639 0.105263157894737 2.59867549668874 0.0664998351958287 0.487834668879323 GO:0140713 histone chaperone activity 11/755 164/18639 0.0670731707317073 1.65586335002423 0.0700887620539214 0.492742133433514 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.492742133433514 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.492742133433514 GO:0019107 myristoyltransferase activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.492742133433514 GO:0140537 transcription regulator activator activity 2/755 11/18639 0.181818181818182 4.48862131246237 0.0707346170714448 0.492742133433514 GO:0005518 collagen binding 6/755 72/18639 0.0833333333333333 2.05728476821192 0.0712396037897459 0.492742133433514 GO:0042379 chemokine receptor binding 6/755 72/18639 0.0833333333333333 2.05728476821192 0.0712396037897459 0.492742133433514 GO:0060229 lipase activator activity 3/755 24/18639 0.125 3.08592715231788 0.0712707144092179 0.492742133433514 GO:0004521 RNA endonuclease activity 6/755 73/18639 0.0821917808219178 2.02910278508573 0.0751009085947274 0.513732744201915 GO:0005543 phospholipid binding 27/755 497/18639 0.0543259557344064 1.34116753501139 0.0754146682459956 0.513732744201915 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/755 91/18639 0.0769230769230769 1.89903209373408 0.0759105615782226 0.513732744201915 GO:0004532 RNA exonuclease activity 4/755 40/18639 0.1 2.4687417218543 0.0773794027571025 0.517694605364412 GO:0033218 amide binding 15/755 247/18639 0.0607287449392713 1.49923586347427 0.07805280826365 0.517694605364412 GO:0017056 structural constituent of nuclear pore 3/755 25/18639 0.12 2.96249006622517 0.0786507933227931 0.517694605364412 GO:0019211 phosphatase activator activity 3/755 25/18639 0.12 2.96249006622517 0.0786507933227931 0.517694605364412 GO:0043178 alcohol binding 7/755 92/18639 0.0760869565217391 1.87839044054132 0.079449203516728 0.519392412105956 GO:0097371 MDM2/MDM4 family protein binding 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.521842203510806 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.521842203510806 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.521842203510806 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.521842203510806 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/755 12/18639 0.166666666666667 4.11456953642384 0.0826671175200074 0.521842203510806 GO:0051213 dioxygenase activity 7/755 93/18639 0.0752688172043011 1.85819269386883 0.0830820573747693 0.521842203510806 GO:0043022 ribosome binding 8/755 112/18639 0.0714285714285714 1.76338694418165 0.0847295395217126 0.52792149047717 GO:0008408 3'-5' exonuclease activity 5/755 58/18639 0.0862068965517241 2.12822562228819 0.0851486274963177 0.52792149047717 GO:0052742 phosphatidylinositol kinase activity 3/755 26/18639 0.115384615384615 2.84854814060112 0.0863485389160048 0.531929140373594 GO:0140034 methylation-dependent protein binding 6/755 76/18639 0.0789473684210526 1.94900662251656 0.0873826272088023 0.534870730876809 GO:0035198 miRNA binding 4/755 42/18639 0.0952380952380952 2.35118259224219 0.0890888066185777 0.538454988430523 GO:0042056 chemoattractant activity 4/755 42/18639 0.0952380952380952 2.35118259224219 0.0890888066185777 0.538454988430523 GO:0036002 pre-mRNA binding 5/755 59/18639 0.0847457627118644 2.09215400157144 0.0901019286255347 0.541174708807118 GO:0005126 cytokine receptor binding 16/755 275/18639 0.0581818181818182 1.43635881998796 0.0941488931370249 0.547833204523535 GO:0016407 acetyltransferase activity 7/755 96/18639 0.0729166666666667 1.80012417218543 0.0945424937812626 0.547833204523535 GO:0004535 poly(A)-specific ribonuclease activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.547833204523535 GO:0019104 DNA N-glycosylase activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.547833204523535 GO:0097157 pre-mRNA intronic binding 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.547833204523535 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/755 13/18639 0.153846153846154 3.79806418746816 0.0951581650034323 0.547833204523535 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/755 60/18639 0.0833333333333333 2.05728476821192 0.0952009835124146 0.547833204523535 GO:0016779 nucleotidyltransferase activity 9/755 136/18639 0.0661764705882353 1.63372613946241 0.101211666185805 0.576848062002643 GO:0001046 core promoter sequence-specific DNA binding 4/755 44/18639 0.0909090909090909 2.24431065623119 0.101594469165029 0.576848062002643 GO:0046966 nuclear thyroid hormone receptor binding 3/755 28/18639 0.107142857142857 2.64508041627247 0.102644140064986 0.576848062002643 GO:0097718 disordered domain specific binding 3/755 28/18639 0.107142857142857 2.64508041627247 0.102644140064986 0.576848062002643 GO:0030246 carbohydrate binding 16/755 280/18639 0.0571428571428571 1.41070955534532 0.105769911030481 0.587149669978726 GO:0005347 ATP transmembrane transporter activity 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.587149669978726 GO:0008191 metalloendopeptidase inhibitor activity 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.587149669978726 GO:0030983 mismatched DNA binding 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.587149669978726 GO:0031404 chloride ion binding 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.587149669978726 GO:0032454 histone H3K9 demethylase activity 2/755 14/18639 0.142857142857143 3.52677388836329 0.108143071369651 0.587149669978726 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/755 29/18639 0.103448275862069 2.55387074674583 0.11121450531239 0.59707899220786 GO:0097472 cyclin-dependent protein kinase activity 3/755 29/18639 0.103448275862069 2.55387074674583 0.11121450531239 0.59707899220786 GO:0008135 translation factor activity, RNA binding 6/755 83/18639 0.072289156626506 1.78463257001516 0.119997908827981 0.631462505278764 GO:0016769 transferase activity, transferring nitrogenous groups 3/755 30/18639 0.1 2.4687417218543 0.120047744898944 0.631462505278764 GO:0015929 hexosaminidase activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.631462505278764 GO:0017081 chloride channel regulator activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.631462505278764 GO:0042809 nuclear vitamin D receptor binding 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.631462505278764 GO:0140776 protein-containing complex destabilizing activity 2/755 15/18639 0.133333333333333 3.29165562913907 0.121561460433477 0.631462505278764 GO:0019207 kinase regulator activity 16/755 287/18639 0.0557491289198606 1.37630200521494 0.12345084355011 0.637829358342233 GO:0004527 exonuclease activity 6/755 84/18639 0.0714285714285714 1.76338694418165 0.125091284454584 0.639429384898164 GO:0180051 translation factor activity 6/755 84/18639 0.0714285714285714 1.76338694418165 0.125091284454584 0.639429384898164 GO:0061134 peptidase regulator activity 13/755 226/18639 0.0575221238938053 1.4200726718631 0.129888887990089 0.660440324648021 GO:0019955 cytokine binding 9/755 144/18639 0.0625 1.54296357615894 0.130774660455955 0.66144446683249 GO:0003688 DNA replication origin binding 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0004708 MAP kinase kinase activity 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0015923 mannosidase activity 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0016722 oxidoreductase activity, acting on metal ions 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0017070 U6 snRNA binding 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0043023 ribosomal large subunit binding 2/755 16/18639 0.125 3.08592715231788 0.135357025542992 0.663663783402119 GO:0008378 galactosyltransferase activity 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.665911850532555 GO:0030515 snoRNA binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.665911850532555 GO:0051059 NF-kappaB binding 3/755 32/18639 0.09375 2.31444536423841 0.138445206754515 0.665911850532555 GO:0030695 GTPase regulator activity 25/755 489/18639 0.0511247443762781 1.26213789460854 0.138587273784091 0.665911850532555 GO:0060589 nucleoside-triphosphatase regulator activity 25/755 490/18639 0.0510204081632653 1.25956210298689 0.140766389111224 0.673017412616347 GO:0004518 nuclease activity 12/755 209/18639 0.0574162679425837 1.41745936183022 0.142759370690165 0.677809427769211 GO:0048020 CCR chemokine receptor binding 4/755 50/18639 0.08 1.97499337748344 0.143478685083792 0.677809427769211 GO:0019783 ubiquitin-like protein peptidase activity 8/755 127/18639 0.062992125984252 1.55511289565625 0.143884623584723 0.677809427769211 GO:0008080 N-acetyltransferase activity 5/755 69/18639 0.072463768115942 1.78894327670602 0.147249967901218 0.684036595158218 GO:0140416 transcription regulator inhibitor activity 3/755 33/18639 0.0909090909090909 2.24431065623119 0.147980391072758 0.684036595158218 GO:0032977 membrane insertase activity 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.684036595158218 GO:0051787 misfolded protein binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.684036595158218 GO:0070403 NAD+ binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.684036595158218 GO:0070492 oligosaccharide binding 2/755 17/18639 0.117647058823529 2.90440202571095 0.14947729967037 0.684036595158218 GO:0008017 microtubule binding 15/755 276/18639 0.0543478260869565 1.34170745752951 0.153244830715585 0.697953944633539 GO:0019842 vitamin binding 9/755 150/18639 0.06 1.48124503311258 0.155611873474318 0.705176953802863 GO:0000510 H3-H4 histone complex chaperone activity 9/755 151/18639 0.0596026490066225 1.47143546335687 0.159961965116225 0.705176953802863 GO:0140584 chromatin extrusion motor activity 9/755 151/18639 0.0596026490066225 1.47143546335687 0.159961965116225 0.705176953802863 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 9/755 151/18639 0.0596026490066225 1.47143546335687 0.159961965116225 0.705176953802863 GO:0140849 ATP-dependent H2AZ histone chaperone activity 9/755 151/18639 0.0596026490066225 1.47143546335687 0.159961965116225 0.705176953802863 GO:0008201 heparin binding 10/755 172/18639 0.0581395348837209 1.43531495456646 0.160953867291081 0.705176953802863 GO:0000400 four-way junction DNA binding 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.705176953802863 GO:0003746 translation elongation factor activity 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.705176953802863 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.705176953802863 GO:0050811 GABA receptor binding 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.705176953802863 GO:0070064 proline-rich region binding 2/755 18/18639 0.111111111111111 2.74304635761589 0.163873437412343 0.705176953802863 GO:0015616 DNA translocase activity 9/755 152/18639 0.0592105263157895 1.46175496688742 0.164370070397337 0.705176953802863 GO:0140674 ATP-dependent histone chaperone activity 9/755 152/18639 0.0592105263157895 1.46175496688742 0.164370070397337 0.705176953802863 GO:0140566 histone reader activity 3/755 35/18639 0.0857142857142857 2.11606433301798 0.167651074173362 0.716056365691559 GO:0061775 cohesin loader activity 9/755 153/18639 0.0588235294117647 1.45220101285547 0.168835309394266 0.717923594371194 GO:0043539 protein serine/threonine kinase activator activity 5/755 73/18639 0.0684931506849315 1.69091898757144 0.17357485649386 0.732570500532131 GO:0003925 G protein activity 4/755 54/18639 0.0740740740740741 1.82869757174393 0.174566747785492 0.732570500532131 GO:0015485 cholesterol binding 4/755 54/18639 0.0740740740740741 1.82869757174393 0.174566747785492 0.732570500532131 GO:0051087 protein-folding chaperone binding 8/755 134/18639 0.0597014925373134 1.47387565483839 0.177009950166878 0.733070546967461 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.733070546967461 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.733070546967461 GO:0042800 histone H3K4 methyltransferase activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.733070546967461 GO:1990380 K48-linked deubiquitinase activity 2/755 19/18639 0.105263157894737 2.59867549668874 0.178500008314657 0.733070546967461 GO:0035064 methylated histone binding 5/755 74/18639 0.0675675675675676 1.66806873098264 0.180422389290179 0.737812408969625 GO:0016410 N-acyltransferase activity 6/755 94/18639 0.0638297872340425 1.57579258841764 0.181398284683625 0.738659964326118 GO:0001221 transcription coregulator binding 7/755 115/18639 0.0608695652173913 1.50271235243306 0.185376750140504 0.751675345506432 GO:0002020 protease binding 8/755 136/18639 0.0588235294117647 1.45220101285547 0.18704791797303 0.755264912487737 GO:0043394 proteoglycan binding 3/755 37/18639 0.0810810810810811 2.00168247717917 0.18802638574998 0.756039149396363 GO:0140658 ATP-dependent chromatin remodeler activity 9/755 158/18639 0.0569620253164557 1.40624528460055 0.191985554794071 0.764508328087098 GO:0000339 RNA cap binding 2/755 20/18639 0.1 2.4687417218543 0.193314800962711 0.764508328087098 GO:0031418 L-ascorbic acid binding 2/755 20/18639 0.1 2.4687417218543 0.193314800962711 0.764508328087098 GO:0061608 nuclear import signal receptor activity 2/755 20/18639 0.1 2.4687417218543 0.193314800962711 0.764508328087098 GO:0016757 glycosyltransferase activity 14/755 267/18639 0.052434456928839 1.29447131482997 0.196366607725258 0.773394713213003 GO:0003689 DNA clamp loader activity 9/755 160/18639 0.05625 1.38866721854305 0.201611424649647 0.788037424212096 GO:0030295 protein kinase activator activity 8/755 139/18639 0.0575539568345324 1.42085854495212 0.202544478439529 0.788037424212096 GO:0140101 catalytic activity, acting on a tRNA 8/755 139/18639 0.0575539568345324 1.42085854495212 0.202544478439529 0.788037424212096 GO:0005178 integrin binding 9/755 161/18639 0.0559006211180124 1.38004195631607 0.206498473692115 0.793845600776939 GO:0061980 regulatory RNA binding 4/755 58/18639 0.0689655172413793 1.70258049783055 0.207701607898424 0.793845600776939 GO:0008373 sialyltransferase activity 2/755 21/18639 0.0952380952380952 2.35118259224219 0.208278637307029 0.793845600776939 GO:0036122 BMP binding 2/755 21/18639 0.0952380952380952 2.35118259224219 0.208278637307029 0.793845600776939 GO:0000217 DNA secondary structure binding 3/755 39/18639 0.0769230769230769 1.89903209373408 0.208993690943356 0.793845600776939 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/755 39/18639 0.0769230769230769 1.89903209373408 0.208993690943356 0.793845600776939 GO:0046332 SMAD binding 5/755 79/18639 0.0632911392405063 1.56249476066728 0.21606297132927 0.814981936013986 GO:0031593 polyubiquitin modification-dependent protein binding 4/755 59/18639 0.0677966101694915 1.67372320125716 0.216254311845543 0.814981936013986 GO:0032451 demethylase activity 3/755 40/18639 0.075 1.85155629139073 0.219665119715215 0.824602265805943 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/755 22/18639 0.0909090909090909 2.24431065623119 0.223355196717589 0.835192000177445 GO:0008234 cysteine-type peptidase activity 10/755 187/18639 0.053475935828877 1.32018273895952 0.227865381180123 0.847331283444043 GO:0051015 actin filament binding 11/755 209/18639 0.0526315789473684 1.29933774834437 0.228365038930288 0.847331283444043 GO:0001727 lipid kinase activity 3/755 41/18639 0.0731707317073171 1.80639638184461 0.230444023464503 0.848493128541714 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/755 41/18639 0.0731707317073171 1.80639638184461 0.230444023464503 0.848493128541714 GO:0008094 ATP-dependent activity, acting on DNA 11/755 210/18639 0.0523809523809524 1.29315042573321 0.232905985751602 0.85428493247057 GO:0000295 adenine nucleotide transmembrane transporter activity 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.856905253424714 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.856905253424714 GO:0140103 catalytic activity, acting on a glycoprotein 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.856905253424714 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/755 23/18639 0.0869565217391304 2.14673193204722 0.238510849285072 0.856905253424714 GO:0031492 nucleosomal DNA binding 3/755 42/18639 0.0714285714285714 1.76338694418165 0.24131750168342 0.856905253424714 GO:0016887 ATP hydrolysis activity 20/755 417/18639 0.0479616306954436 1.1840487874601 0.249352291487009 0.856905253424714 GO:0019209 kinase activator activity 8/755 148/18639 0.0540540540540541 1.33445498478611 0.251835674733752 0.856905253424714 GO:0008200 ion channel inhibitor activity 3/755 43/18639 0.0697674418604651 1.72237794547975 0.252272982661934 0.856905253424714 GO:0048027 mRNA 5'-UTR binding 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.856905253424714 GO:0050431 transforming growth factor beta binding 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.856905253424714 GO:0070300 phosphatidic acid binding 2/755 24/18639 0.0833333333333333 2.05728476821192 0.25371449791015 0.856905253424714 GO:0031490 chromatin DNA binding 7/755 128/18639 0.0546875 1.35009312913907 0.262261201098589 0.856905253424714 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 7/755 128/18639 0.0546875 1.35009312913907 0.262261201098589 0.856905253424714 GO:0016248 channel inhibitor activity 3/755 44/18639 0.0681818181818182 1.68323299217339 0.263298239747073 0.856905253424714 GO:0030547 signaling receptor inhibitor activity 3/755 44/18639 0.0681818181818182 1.68323299217339 0.263298239747073 0.856905253424714 GO:0000030 mannosyltransferase activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.856905253424714 GO:0008139 nuclear localization sequence binding 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.856905253424714 GO:0008483 transaminase activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.856905253424714 GO:0017025 TBP-class protein binding 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.856905253424714 GO:0120020 cholesterol transfer activity 2/755 25/18639 0.08 1.97499337748344 0.268937428743832 0.856905253424714 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/755 86/18639 0.0581395348837209 1.43531495456646 0.269144375565216 0.856905253424714 GO:0016209 antioxidant activity 5/755 86/18639 0.0581395348837209 1.43531495456646 0.269144375565216 0.856905253424714 GO:0120013 lipid transfer activity 4/755 65/18639 0.0615384615384615 1.51922567498726 0.269307882539479 0.856905253424714 GO:0005496 steroid binding 6/755 108/18639 0.0555555555555556 1.37152317880795 0.27327276411048 0.856905253424714 GO:0141110 transporter inhibitor activity 3/755 45/18639 0.0666666666666667 1.64582781456954 0.274381404877851 0.856905253424714 GO:0016758 hexosyltransferase activity 10/755 197/18639 0.050761421319797 1.25316838672807 0.277503181790329 0.856905253424714 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 12/755 243/18639 0.0493827160493827 1.21913171449595 0.2819089834715 0.856905253424714 GO:0005112 Notch binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0015216 purine nucleotide transmembrane transporter activity 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0019865 immunoglobulin binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0030247 polysaccharide binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0050681 nuclear androgen receptor binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0097602 cullin family protein binding 2/755 26/18639 0.0769230769230769 1.89903209373408 0.284153169562818 0.856905253424714 GO:0030276 clathrin binding 3/755 46/18639 0.0652173913043478 1.61004894903542 0.285510979624206 0.856905253424714 GO:0004222 metalloendopeptidase activity 6/755 110/18639 0.0545454545454545 1.34658639373871 0.28726399894198 0.856905253424714 GO:0008173 RNA methyltransferase activity 4/755 67/18639 0.0597014925373134 1.47387565483839 0.287495049821745 0.856905253424714 GO:0050840 extracellular matrix binding 4/755 67/18639 0.0597014925373134 1.47387565483839 0.287495049821745 0.856905253424714 GO:0140097 catalytic activity, acting on DNA 16/755 336/18639 0.0476190476190476 1.1755912961211 0.288623124796163 0.856905253424714 GO:0004676 3-phosphoinositide-dependent protein kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0004711 ribosomal protein S6 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0035175 histone H3S10 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0035979 histone H2AXS139 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0044022 histone H3S28 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0044023 histone H4S1 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0044024 histone H2AS1 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0044025 histone H2BS14 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0072354 histone H3T3 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0072371 histone H2AS121 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0072518 Rho-dependent protein serine/threonine kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0140823 histone H2BS36 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0140855 histone H3S57 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0140995 histone H2A kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0140997 histone H4 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0140998 histone H2B kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:1990244 histone H2AT120 kinase activity 12/755 245/18639 0.0489795918367347 1.20917961886741 0.291220132797949 0.856905253424714 GO:0004386 helicase activity 8/755 155/18639 0.0516129032258065 1.27418927579577 0.292525633330643 0.856905253424714 GO:1902936 phosphatidylinositol bisphosphate binding 6/755 111/18639 0.0540540540540541 1.33445498478611 0.294316520311376 0.856905253424714 GO:0004677 DNA-dependent protein kinase activity 12/755 246/18639 0.0487804878048781 1.20426425456308 0.295909123464628 0.856905253424714 GO:0140857 histone H3T45 kinase activity 12/755 246/18639 0.0487804878048781 1.20426425456308 0.295909123464628 0.856905253424714 GO:0106310 protein serine kinase activity 17/755 361/18639 0.0470914127423823 1.16256535378181 0.29615512807546 0.856905253424714 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/755 68/18639 0.0588235294117647 1.45220101285547 0.2966538941977 0.856905253424714 GO:0140938 histone H3 methyltransferase activity 3/755 47/18639 0.0638297872340425 1.57579258841764 0.296675843942995 0.856905253424714 GO:0035402 histone H3T11 kinase activity 12/755 247/18639 0.048582995951417 1.19938869077942 0.300619316999322 0.856905253424714 GO:0035403 histone H3T6 kinase activity 12/755 247/18639 0.048582995951417 1.19938869077942 0.300619316999322 0.856905253424714 GO:0005200 structural constituent of cytoskeleton 6/755 112/18639 0.0535714285714286 1.32254020813623 0.30140315934742 0.856905253424714 GO:0004679 AMP-activated protein kinase activity 12/755 248/18639 0.0483870967741935 1.19455244605853 0.305349901964039 0.856905253424714 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/755 48/18639 0.0625 1.54296357615894 0.307865262849596 0.856905253424714 GO:0019838 growth factor binding 7/755 136/18639 0.0514705882352941 1.27067588624854 0.313409356163466 0.856905253424714 GO:0019789 SUMO transferase activity 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.856905253424714 GO:0051019 mitogen-activated protein kinase binding 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.856905253424714 GO:0141052 histone H3 demethylase activity 2/755 28/18639 0.0714285714285714 1.76338694418165 0.314467603038997 0.856905253424714 GO:0097110 scaffold protein binding 4/755 70/18639 0.0571428571428571 1.41070955534532 0.315071258393766 0.856905253424714 GO:0016763 pentosyltransferase activity 3/755 49/18639 0.0612244897959184 1.51147452358427 0.31906889119009 0.856905253424714 GO:0101005 deubiquitinase activity 6/755 115/18639 0.0521739130434783 1.28803915922833 0.32283937309243 0.856905253424714 GO:1901681 sulfur compound binding 13/755 275/18639 0.0472727272727273 1.16704154124022 0.323870099684272 0.856905253424714 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 11/755 229/18639 0.0480349344978166 1.18585846901298 0.324745021115278 0.856905253424714 GO:0004629 phospholipase C activity 2/755 29/18639 0.0689655172413793 1.70258049783055 0.329523388055783 0.856905253424714 GO:0035250 UDP-galactosyltransferase activity 2/755 29/18639 0.0689655172413793 1.70258049783055 0.329523388055783 0.856905253424714 GO:0043236 laminin binding 2/755 29/18639 0.0689655172413793 1.70258049783055 0.329523388055783 0.856905253424714 GO:0051861 glycolipid binding 2/755 29/18639 0.0689655172413793 1.70258049783055 0.329523388055783 0.856905253424714 GO:0008237 metallopeptidase activity 9/755 184/18639 0.0489130434782609 1.20753671177656 0.329622339746253 0.856905253424714 GO:0061135 endopeptidase regulator activity 9/755 184/18639 0.0489130434782609 1.20753671177656 0.329622339746253 0.856905253424714 GO:0009055 electron transfer activity 6/755 116/18639 0.0517241379310345 1.27693537337292 0.330034161542707 0.856905253424714 GO:0042562 hormone binding 5/755 94/18639 0.0531914893617021 1.31316049034803 0.332707406965606 0.856905253424714 GO:0003796 lysozyme activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0004090 carbonyl reductase (NADPH) activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0004955 prostaglandin receptor activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0005131 growth hormone receptor binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0005528 FK506 binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0008190 eukaryotic initiation factor 4E binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0016783 sulfurtransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0030957 Tat protein binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0031720 haptoglobin binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0031996 thioesterase binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0032356 oxidized DNA binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0042975 peroxisome proliferator activated receptor binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0043208 glycosphingolipid binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0043295 glutathione binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0070513 death domain binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0099122 RNA polymerase II C-terminal domain binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0140135 mechanosensitive monoatomic cation channel activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0140940 histone H2A methyltransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0140999 histone H3K4 trimethyltransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:1905394 retromer complex binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:1990259 histone H2AQ104 methyltransferase activity 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:1990763 arrestin family protein binding 1/755 10/18639 0.1 2.4687417218543 0.338733915788378 0.856905253424714 GO:0019887 protein kinase regulator activity 12/755 255/18639 0.0470588235294118 1.16176081028438 0.338966085004823 0.856905253424714 GO:0003743 translation initiation factor activity 3/755 51/18639 0.0588235294117647 1.45220101285547 0.341479361413469 0.856905253424714 GO:0008187 poly-pyrimidine tract binding 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.856905253424714 GO:0015215 nucleotide transmembrane transporter activity 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.856905253424714 GO:0032452 histone demethylase activity 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.856905253424714 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/755 30/18639 0.0666666666666667 1.64582781456954 0.344485933995557 0.856905253424714 GO:0031491 nucleosome binding 4/755 74/18639 0.0540540540540541 1.33445498478611 0.352139546617825 0.856905253424714 GO:0030159 signaling receptor complex adaptor activity 3/755 52/18639 0.0576923076923077 1.42427407030056 0.352667481860875 0.856905253424714 GO:0005164 tumor necrosis factor receptor binding 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.856905253424714 GO:0016878 acid-thiol ligase activity 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.856905253424714 GO:0140457 protein demethylase activity 2/755 31/18639 0.0645161290322581 1.59273659474471 0.359338103429735 0.856905253424714 GO:0031267 small GTPase binding 13/755 283/18639 0.0459363957597173 1.13405096763625 0.361111485567642 0.856905253424714 GO:0003725 double-stranded RNA binding 4/755 75/18639 0.0533333333333333 1.31666225165563 0.36142240718958 0.856905253424714 GO:0044183 protein folding chaperone 4/755 75/18639 0.0533333333333333 1.31666225165563 0.36142240718958 0.856905253424714 GO:0140296 general transcription initiation factor binding 3/755 53/18639 0.0566037735849057 1.39740097463451 0.363832367711558 0.856905253424714 GO:0003953 NAD+ nucleosidase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0004954 prostanoid receptor activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0015173 aromatic amino acid transmembrane transporter activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0015217 ADP transmembrane transporter activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0019206 nucleoside kinase activity 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0019864 IgG binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0032404 mismatch repair complex binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0032794 GTPase activating protein binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0034056 estrogen response element binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0034713 type I transforming growth factor beta receptor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0043522 leucine zipper domain binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0048185 activin binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0050786 RAGE receptor binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0070990 snRNP binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:1900750 oligopeptide binding 1/755 11/18639 0.0909090909090909 2.24431065623119 0.365533845660071 0.856905253424714 GO:0019903 protein phosphatase binding 7/755 144/18639 0.0486111111111111 1.20008278145695 0.366167745997353 0.856905253424714 GO:0003697 single-stranded DNA binding 6/755 121/18639 0.0495867768595041 1.22416944885337 0.366254462147536 0.856905253424714 GO:0051082 unfolded protein binding 6/755 121/18639 0.0495867768595041 1.22416944885337 0.366254462147536 0.856905253424714 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.856905253424714 GO:0120015 sterol transfer activity 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.856905253424714 GO:0140142 nucleocytoplasmic carrier activity 2/755 32/18639 0.0625 1.54296357615894 0.374064296541417 0.856905253424714 GO:0017069 snRNA binding 3/755 54/18639 0.0555555555555556 1.37152317880795 0.374965639471915 0.856905253424714 GO:0051287 NAD binding 3/755 54/18639 0.0555555555555556 1.37152317880795 0.374965639471915 0.856905253424714 GO:0140463 chromatin-protein adaptor activity 3/755 54/18639 0.0555555555555556 1.37152317880795 0.374965639471915 0.856905253424714 GO:0008374 O-acyltransferase activity 3/755 55/18639 0.0545454545454545 1.34658639373871 0.386059305068996 0.856905253424714 GO:0000340 RNA 7-methylguanosine cap binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0003995 acyl-CoA dehydrogenase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0005165 neurotrophin receptor binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0005527 macrolide binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0015368 calcium:monoatomic cation antiporter activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0016273 arginine N-methyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0016274 protein-arginine N-methyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0016423 tRNA (guanine) methyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0016840 carbon-nitrogen lyase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0017166 vinculin binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0031543 peptidyl-proline dioxygenase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0035197 siRNA binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0036009 protein-glutamine N-methyltransferase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0070679 inositol 1,4,5 trisphosphate binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0097677 STAT family protein binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:1990459 transferrin receptor binding 1/755 12/18639 0.0833333333333333 2.05728476821192 0.391249002763713 0.856905253424714 GO:0015631 tubulin binding 17/755 385/18639 0.0441558441558442 1.09009374731229 0.392599317033157 0.856905253424714 GO:0004674 protein serine/threonine kinase activity 19/755 433/18639 0.0438799076212471 1.08328158695685 0.393244968303645 0.856905253424714 GO:0030170 pyridoxal phosphate binding 3/755 56/18639 0.0535714285714286 1.32254020813623 0.397105755526475 0.856905253424714 GO:0033293 monocarboxylic acid binding 4/755 79/18639 0.0506329113924051 1.24999580853383 0.398459632940935 0.856905253424714 GO:0051020 GTPase binding 14/755 315/18639 0.0444444444444444 1.09721854304636 0.399700043933489 0.856905253424714 GO:0008175 tRNA methyltransferase activity 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.856905253424714 GO:0008376 acetylgalactosaminyltransferase activity 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.856905253424714 GO:0015035 protein-disulfide reductase activity 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.856905253424714 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/755 34/18639 0.0588235294117647 1.45220101285547 0.40308347083957 0.856905253424714 GO:0004601 peroxidase activity 3/755 57/18639 0.0526315789473684 1.29933774834437 0.408097759821529 0.856905253424714 GO:0070279 vitamin B6 binding 3/755 57/18639 0.0526315789473684 1.29933774834437 0.408097759821529 0.856905253424714 GO:0004519 endonuclease activity 6/755 127/18639 0.047244094488189 1.16633467174219 0.409912237572497 0.856905253424714 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0005542 folic acid binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0017154 semaphorin receptor activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0031994 insulin-like growth factor I binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0035325 Toll-like receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0039706 co-receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0046975 histone H3K36 methyltransferase activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0051011 microtubule minus-end binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0070700 BMP receptor binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0089720 caspase binding 1/755 13/18639 0.0769230769230769 1.89903209373408 0.415923239243737 0.856905253424714 GO:0005154 epidermal growth factor receptor binding 2/755 35/18639 0.0571428571428571 1.41070955534532 0.417352100940552 0.856905253424714 GO:0016229 steroid dehydrogenase activity 2/755 35/18639 0.0571428571428571 1.41070955534532 0.417352100940552 0.856905253424714 GO:0043015 gamma-tubulin binding 2/755 35/18639 0.0571428571428571 1.41070955534532 0.417352100940552 0.856905253424714 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/755 58/18639 0.0517241379310345 1.27693537337292 0.419028459017334 0.856905253424714 GO:0001664 G protein-coupled receptor binding 13/755 297/18639 0.0437710437710438 1.08059401966687 0.427558412952511 0.856905253424714 GO:0008013 beta-catenin binding 5/755 106/18639 0.0471698113207547 1.16450081219543 0.429643665775288 0.856905253424714 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3/755 59/18639 0.0508474576271186 1.25529240094287 0.42989135975868 0.856905253424714 GO:0004190 aspartic-type endopeptidase activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.856905253424714 GO:0016409 palmitoyltransferase activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.856905253424714 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.856905253424714 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.856905253424714 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/755 36/18639 0.0555555555555556 1.37152317880795 0.431445885417076 0.856905253424714 GO:0005506 iron ion binding 7/755 154/18639 0.0454545454545455 1.12215532811559 0.432771999501746 0.856905253424714 GO:0004705 JUN kinase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0005344 oxygen carrier activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0005545 1-phosphatidylinositol binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0008174 mRNA methyltransferase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0008195 phosphatidate phosphatase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0008331 high voltage-gated calcium channel activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0008474 palmitoyl-(protein) hydrolase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0015926 glucosidase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0019763 immunoglobulin receptor activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0032036 myosin heavy chain binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0034236 protein kinase A catalytic subunit binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0042813 Wnt receptor activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0044548 S100 protein binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0061783 peptidoglycan muralytic activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0070742 C2H2 zinc finger domain binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0098599 palmitoyl hydrolase activity 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:1901612 cardiolipin binding 1/755 14/18639 0.0714285714285714 1.76338694418165 0.439598636772512 0.856905253424714 GO:0003714 transcription corepressor activity 9/755 204/18639 0.0441176470588235 1.08915075964161 0.445074772990458 0.862876419030155 GO:0019213 deacetylase activity 2/755 37/18639 0.0540540540540541 1.33445498478611 0.445355571112338 0.862876419030155 GO:0070001 aspartic-type peptidase activity 2/755 37/18639 0.0540540540540541 1.33445498478611 0.445355571112338 0.862876419030155 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/755 181/18639 0.0441988950276243 1.09115656214555 0.451797949049798 0.866053158674352 GO:0000146 microfilament motor activity 2/755 38/18639 0.0526315789473684 1.29933774834437 0.459072939106021 0.866053158674352 GO:0005109 frizzled binding 2/755 38/18639 0.0526315789473684 1.29933774834437 0.459072939106021 0.866053158674352 GO:0050660 flavin adenine dinucleotide binding 4/755 86/18639 0.0465116279069767 1.14825196365316 0.46219705633505 0.866053158674352 GO:0004129 cytochrome-c oxidase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0004559 alpha-mannosidase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0004953 icosanoid receptor activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0005523 tropomyosin binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0033130 acetylcholine receptor binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0048531 beta-1,3-galactosyltransferase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0050700 CARD domain binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0120283 protein serine/threonine kinase binding 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0141050 histone H3K deacetylase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0141051 histone H4K deacetylase activity 1/755 15/18639 0.0666666666666667 1.64582781456954 0.462315577939587 0.866053158674352 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/755 39/18639 0.0512820512820513 1.26602139582272 0.472590736304003 0.871868408502076 GO:0044325 transmembrane transporter binding 6/755 136/18639 0.0441176470588235 1.08915075964161 0.474699603113229 0.871868408502076 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/755 88/18639 0.0454545454545455 1.12215532811559 0.479995880273362 0.871868408502076 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0004707 MAP kinase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0005159 insulin-like growth factor receptor binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0019841 retinol binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0022841 potassium ion leak channel activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0022858 alanine transmembrane transporter activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0030275 LRR domain binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0070411 I-SMAD binding 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/755 16/18639 0.0625 1.54296357615894 0.484112814766026 0.871868408502076 GO:0015036 disulfide oxidoreductase activity 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.871868408502076 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.871868408502076 GO:0030331 nuclear estrogen receptor binding 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.871868408502076 GO:0061791 GTPase motor activity 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.871868408502076 GO:1990606 membrane scission GTPase motor activity 2/755 40/18639 0.05 1.23437086092715 0.485902610861308 0.871868408502076 GO:0003727 single-stranded RNA binding 4/755 89/18639 0.0449438202247191 1.10954684128283 0.488808853326742 0.871868408502076 GO:0160215 deacylase activity 3/755 65/18639 0.0461538461538462 1.13941925624045 0.493325559691447 0.871868408502076 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/755 41/18639 0.0487804878048781 1.20426425456308 0.499003051240631 0.871868408502076 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/755 41/18639 0.0487804878048781 1.20426425456308 0.499003051240631 0.871868408502076 GO:0042287 MHC protein binding 2/755 41/18639 0.0487804878048781 1.20426425456308 0.499003051240631 0.871868408502076 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0005092 GDP-dissociation inhibitor activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0008429 phosphatidylethanolamine binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0015278 intracellularly gated calcium channel activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0017110 nucleoside diphosphate phosphatase activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0030548 acetylcholine receptor regulator activity 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0036041 long-chain fatty acid binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0038191 neuropilin binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0045236 CXCR chemokine receptor binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0046965 nuclear retinoid X receptor binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0048038 quinone binding 1/755 17/18639 0.0588235294117647 1.45220101285547 0.505027534459504 0.871868408502076 GO:0019902 phosphatase binding 8/755 190/18639 0.0421052631578947 1.0394701986755 0.506468312182262 0.871868408502076 GO:0015399 primary active transmembrane transporter activity 7/755 166/18639 0.0421686746987952 1.04103566584218 0.511213814022389 0.871868408502076 GO:0016859 cis-trans isomerase activity 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.871868408502076 GO:0019894 kinesin binding 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.871868408502076 GO:0048487 beta-tubulin binding 2/755 42/18639 0.0476190476190476 1.1755912961211 0.511887328718491 0.871868408502076 GO:0042054 histone methyltransferase activity 3/755 67/18639 0.0447761194029851 1.10540674112879 0.513689275553454 0.871868408502076 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 7/755 167/18639 0.0419161676646707 1.03480191934013 0.517596938566578 0.871868408502076 GO:0005539 glycosaminoglycan binding 10/755 242/18639 0.0413223140495868 1.02014120737781 0.519903432529646 0.871868408502076 GO:0004857 enzyme inhibitor activity 17/755 416/18639 0.0408653846153846 1.00886079979623 0.52044340328318 0.871868408502076 GO:0005548 phospholipid transporter activity 3/755 68/18639 0.0441176470588235 1.08915075964161 0.523706293154488 0.871868408502076 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/755 43/18639 0.0465116279069767 1.14825196365316 0.524551443160275 0.871868408502076 GO:0008375 acetylglucosaminyltransferase activity 2/755 43/18639 0.0465116279069767 1.14825196365316 0.524551443160275 0.871868408502076 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/755 43/18639 0.0465116279069767 1.14825196365316 0.524551443160275 0.871868408502076 GO:0008409 5'-3' exonuclease activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0016854 racemase and epimerase activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0017075 syntaxin-1 binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0017128 phospholipid scramblase activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0035615 clathrin adaptor activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0070628 proteasome binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0098641 cadherin binding involved in cell-cell adhesion 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0099602 neurotransmitter receptor regulator activity 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:1901611 phosphatidylglycerol binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:1990381 ubiquitin-specific protease binding 1/755 18/18639 0.0555555555555556 1.37152317880795 0.525095422521102 0.871868408502076 GO:0030414 peptidase inhibitor activity 7/755 169/18639 0.0414201183431953 1.02255574277989 0.530271227987854 0.871868408502076 GO:0016279 protein-lysine N-methyltransferase activity 3/755 69/18639 0.0434782608695652 1.07336596602361 0.533608943662884 0.871868408502076 GO:0003954 NADH dehydrogenase activity 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.871868408502076 GO:0016790 thiolester hydrolase activity 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.871868408502076 GO:0043014 alpha-tubulin binding 2/755 44/18639 0.0454545454545455 1.12215532811559 0.536992071894236 0.871868408502076 GO:0008194 UDP-glycosyltransferase activity 6/755 145/18639 0.0413793103448276 1.02154829869833 0.53729225164573 0.871868408502076 GO:0008276 protein methyltransferase activity 4/755 95/18639 0.0421052631578947 1.0394701986755 0.540290380279314 0.871868408502076 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/755 70/18639 0.0428571428571429 1.05803216650899 0.543394213152546 0.871868408502076 GO:0016278 lysine N-methyltransferase activity 3/755 70/18639 0.0428571428571429 1.05803216650899 0.543394213152546 0.871868408502076 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0005520 insulin-like growth factor binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0008301 DNA binding, bending 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0008381 mechanosensitive monoatomic ion channel activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0008574 plus-end-directed microtubule motor activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0015245 fatty acid transmembrane transporter activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0016918 retinal binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0022840 leak channel activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0022842 narrow pore channel activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0031420 alkali metal ion binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0034987 immunoglobulin receptor binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0042577 lipid phosphatase activity 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0043395 heparan sulfate proteoglycan binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0097001 ceramide binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0120227 acyl-CoA binding 1/755 19/18639 0.0526315789473684 1.29933774834437 0.544350723310349 0.871868408502076 GO:0051539 4 iron, 4 sulfur cluster binding 2/755 45/18639 0.0444444444444444 1.09721854304636 0.549206521522906 0.876723367414473 GO:0140303 intramembrane lipid transporter activity 2/755 45/18639 0.0444444444444444 1.09721854304636 0.549206521522906 0.876723367414473 GO:0140299 molecular sensor activity 3/755 71/18639 0.0422535211267606 1.04313030500886 0.553059349428702 0.88140967628687 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/755 46/18639 0.0434782608695652 1.07336596602361 0.561192682518302 0.885230887957597 GO:0030291 protein serine/threonine kinase inhibitor activity 2/755 46/18639 0.0434782608695652 1.07336596602361 0.561192682518302 0.885230887957597 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0030742 GTP-dependent protein binding 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0042288 MHC class I protein binding 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0043024 ribosomal small subunit binding 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0140664 ATP-dependent DNA damage sensor activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0140939 histone H4 methyltransferase activity 1/755 20/18639 0.05 1.23437086092715 0.562826298170751 0.885230887957597 GO:0005504 fatty acid binding 2/755 47/18639 0.0425531914893617 1.05052839227843 0.572948986454982 0.895736053674889 GO:0043495 protein-membrane adaptor activity 2/755 47/18639 0.0425531914893617 1.05052839227843 0.572948986454982 0.895736053674889 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0019200 carbohydrate kinase activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0061891 calcium ion sensor activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0140312 cargo adaptor activity 1/755 21/18639 0.0476190476190476 1.1755912961211 0.580553681213937 0.895736053674889 GO:0048029 monosaccharide binding 3/755 74/18639 0.0405405405405405 1.00084123858958 0.581310166983026 0.895736053674889 GO:0005319 lipid transporter activity 7/755 178/18639 0.0393258426966292 0.970853486122479 0.585554472686091 0.895736053674889 GO:0008168 methyltransferase activity 8/755 204/18639 0.0392156862745098 0.968134008570316 0.587602574571335 0.895736053674889 GO:0019003 GDP binding 3/755 75/18639 0.04 0.987496688741722 0.590472156974419 0.895736053674889 GO:0004407 histone deacetylase activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0008093 cytoskeletal anchor activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0008649 rRNA methyltransferase activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0008970 phospholipase A1 activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0031683 G-protein beta/gamma-subunit complex binding 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0033558 protein lysine deacetylase activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0050321 tau-protein kinase activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0070034 telomerase RNA binding 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0140517 protein-RNA adaptor activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0140784 metal ion sensor activity 1/755 22/18639 0.0454545454545455 1.12215532811559 0.597563132856621 0.895736053674889 GO:0017022 myosin binding 3/755 76/18639 0.0394736842105263 0.974503311258278 0.599503853636911 0.895736053674889 GO:0051536 iron-sulfur cluster binding 3/755 76/18639 0.0394736842105263 0.974503311258278 0.599503853636911 0.895736053674889 GO:0035591 signaling adaptor activity 5/755 129/18639 0.0387596899224806 0.956876636377637 0.603060692285507 0.895736053674889 GO:0004722 protein serine/threonine phosphatase activity 4/755 103/18639 0.0388349514563107 0.958734649263808 0.604550038814836 0.895736053674889 GO:0015605 organophosphate ester transmembrane transporter activity 2/755 50/18639 0.04 0.987496688741722 0.606830359016315 0.895736053674889 GO:0032813 tumor necrosis factor receptor superfamily binding 2/755 50/18639 0.04 0.987496688741722 0.606830359016315 0.895736053674889 GO:0051540 metal cluster binding 3/755 77/18639 0.038961038961039 0.96184742409908 0.608403881259011 0.895736053674889 GO:0003887 DNA-directed DNA polymerase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0004602 glutathione peroxidase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0005212 structural constituent of eye lens 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0016493 C-C chemokine receptor activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0017134 fibroblast growth factor binding 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0042171 lysophosphatidic acid acyltransferase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0043274 phospholipase binding 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0071617 lysophospholipid acyltransferase activity 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0099186 structural constituent of postsynapse 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0140102 catalytic activity, acting on a rRNA 1/755 23/18639 0.0434782608695652 1.07336596602361 0.613883691200782 0.895736053674889 GO:0005048 signal sequence binding 2/755 51/18639 0.0392156862745098 0.968134008570316 0.617661011979697 0.895736053674889 GO:0030544 Hsp70 protein binding 2/755 51/18639 0.0392156862745098 0.968134008570316 0.617661011979697 0.895736053674889 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 5/755 132/18639 0.0378787878787879 0.935129440096327 0.623420554840166 0.895736053674889 GO:0003779 actin binding 17/755 443/18639 0.0383747178329571 0.947372669786076 0.625688755418716 0.895736053674889 GO:0005080 protein kinase C binding 2/755 52/18639 0.0384615384615385 0.94951604686704 0.62826075318445 0.895736053674889 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0005315 phosphate transmembrane transporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0015149 hexose transmembrane transporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0015295 solute:proton symporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0019957 C-C chemokine binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0055056 D-glucose transmembrane transporter activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0140612 DNA damage sensor activity 1/755 24/18639 0.0416666666666667 1.02864238410596 0.629543221343853 0.895736053674889 GO:0048306 calcium-dependent protein binding 3/755 80/18639 0.0375 0.925778145695364 0.634303111625188 0.895736053674889 GO:0019888 protein phosphatase regulator activity 4/755 107/18639 0.0373831775700935 0.922894101627777 0.634552297312171 0.895736053674889 GO:0031406 carboxylic acid binding 7/755 187/18639 0.0374331550802139 0.924127917271665 0.637439788420779 0.895736053674889 GO:0016860 intramolecular oxidoreductase activity 2/755 53/18639 0.0377358490566038 0.931600649756341 0.63863049379123 0.895736053674889 GO:0017046 peptide hormone binding 2/755 53/18639 0.0377358490566038 0.931600649756341 0.63863049379123 0.895736053674889 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/755 53/18639 0.0377358490566038 0.931600649756341 0.63863049379123 0.895736053674889 GO:0004866 endopeptidase inhibitor activity 6/755 161/18639 0.0372670807453416 0.920027970877381 0.639590643066619 0.895736053674889 GO:0004843 cysteine-type deubiquitinase activity 4/755 108/18639 0.037037037037037 0.914348785871965 0.64181860972975 0.895736053674889 GO:0030971 receptor tyrosine kinase binding 3/755 81/18639 0.037037037037037 0.914348785871965 0.642666538296782 0.895736053674889 GO:0001848 complement binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0005537 D-mannose binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0015271 outward rectifier potassium channel activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0015645 fatty acid ligase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0019707 protein-cysteine S-acyltransferase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0042974 nuclear retinoic acid receptor binding 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0047617 fatty acyl-CoA hydrolase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0120515 fatty acid-CoA ligase activity 1/755 25/18639 0.04 0.987496688741722 0.644568462702187 0.895736053674889 GO:0016741 transferase activity, transferring one-carbon groups 8/755 215/18639 0.0372093023255814 0.918601570922532 0.646564984056859 0.895736053674889 GO:0043177 organic acid binding 7/755 189/18639 0.037037037037037 0.914348785871965 0.648450675345493 0.895736053674889 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/755 54/18639 0.037037037037037 0.914348785871965 0.648771449726588 0.895736053674889 GO:0004620 phospholipase activity 4/755 109/18639 0.036697247706422 0.905960264900662 0.648989637817424 0.895736053674889 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/755 82/18639 0.0365853658536585 0.903198190922307 0.650894218058532 0.895736053674889 GO:0001637 G protein-coupled chemoattractant receptor activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0004435 phosphatidylinositol phospholipase C activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0004529 DNA exonuclease activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0004950 chemokine receptor activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0005160 transforming growth factor beta receptor binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0015145 monosaccharide transmembrane transporter activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0016289 acyl-CoA hydrolase activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0034237 protein kinase A regulatory subunit binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0043548 phosphatidylinositol 3-kinase binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0051139 metal cation:proton antiporter activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0070006 metalloaminopeptidase activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0070412 R-SMAD binding 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0120014 phospholipid transfer activity 1/755 26/18639 0.0384615384615385 0.94951604686704 0.658985074427762 0.895736053674889 GO:0005254 chloride channel activity 3/755 83/18639 0.036144578313253 0.89231628500758 0.658985837615137 0.895736053674889 GO:0004860 protein kinase inhibitor activity 3/755 84/18639 0.0357142857142857 0.881693472090823 0.666941232662641 0.90430460071894 GO:0001671 ATPase activator activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0004364 glutathione transferase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0008266 poly(U) RNA binding 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0008320 protein transmembrane transporter activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0016405 CoA-ligase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/755 27/18639 0.037037037037037 0.914348785871965 0.672817678994841 0.90430460071894 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/755 57/18639 0.0350877192982456 0.866225165562914 0.6778378029244 0.908824042873663 GO:0141003 histone H2AX kinase activity 13/755 354/18639 0.0367231638418079 0.906600067347626 0.680730419058822 0.908824042873663 GO:0005242 inward rectifier potassium channel activity 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0046625 sphingolipid binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0046875 ephrin receptor binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0050698 proteoglycan sulfotransferase activity 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0051119 sugar transmembrane transporter activity 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0051393 alpha-actinin binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0051537 2 iron, 2 sulfur cluster binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/755 28/18639 0.0357142857142857 0.881693472090823 0.686089904030243 0.908824042873663 GO:0020037 heme binding 5/755 142/18639 0.0352112676056338 0.869275254174051 0.686582991806742 0.908824042873663 GO:0140996 histone H3 kinase activity 13/755 357/18639 0.0364145658263305 0.898981579386722 0.692193509438132 0.914990319903775 GO:0003785 actin monomer binding 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.917445724019186 GO:0016417 S-acyltransferase activity 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.917445724019186 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.917445724019186 GO:0099604 ligand-gated calcium channel activity 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.917445724019186 GO:0106222 lncRNA binding 1/755 29/18639 0.0344827586206897 0.851290248915277 0.698824422457902 0.917445724019186 GO:0019208 phosphatase regulator activity 4/755 117/18639 0.0341880341880342 0.844014263881814 0.702871699154308 0.920949971698261 GO:0035173 histone kinase activity 13/755 360/18639 0.0361111111111111 0.891490066225165 0.70341028015247 0.920949971698261 GO:0022853 active monoatomic ion transmembrane transporter activity 4/755 118/18639 0.0338983050847458 0.836861600628578 0.709167649009159 0.921613153919816 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0033612 receptor serine/threonine kinase binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0048019 receptor antagonist activity 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0051721 protein phosphatase 2A binding 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0098918 structural constituent of synapse 1/755 30/18639 0.0333333333333333 0.822913907284768 0.711042991025569 0.921613153919816 GO:0019210 kinase inhibitor activity 3/755 90/18639 0.0333333333333333 0.822913907284768 0.711820608984956 0.921613153919816 GO:0015026 coreceptor activity 2/755 61/18639 0.0327868852459016 0.809423515362067 0.713506957873406 0.921613153919816 GO:0016836 hydro-lyase activity 2/755 61/18639 0.0327868852459016 0.809423515362067 0.713506957873406 0.921613153919816 GO:0072341 modified amino acid binding 3/755 91/18639 0.032967032967033 0.813870897314606 0.718828820280079 0.926104792366522 GO:0005452 solute:inorganic anion antiporter activity 1/755 31/18639 0.032258064516129 0.796368297372356 0.722766487278763 0.926104792366522 GO:0008327 methyl-CpG binding 1/755 31/18639 0.032258064516129 0.796368297372356 0.722766487278763 0.926104792366522 GO:0016411 acylglycerol O-acyltransferase activity 1/755 31/18639 0.032258064516129 0.796368297372356 0.722766487278763 0.926104792366522 GO:0047499 calcium-independent phospholipase A2 activity 1/755 31/18639 0.032258064516129 0.796368297372356 0.722766487278763 0.926104792366522 GO:0070273 phosphatidylinositol-4-phosphate binding 1/755 31/18639 0.032258064516129 0.796368297372356 0.722766487278763 0.926104792366522 GO:0005507 copper ion binding 2/755 63/18639 0.0317460317460317 0.783727530747398 0.730065233682749 0.926922946370236 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/755 122/18639 0.0327868852459016 0.809423515362067 0.733376315318617 0.926922946370236 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/755 122/18639 0.0327868852459016 0.809423515362067 0.733376315318617 0.926922946370236 GO:0022884 macromolecule transmembrane transporter activity 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0031369 translation initiation factor binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0042910 xenobiotic transmembrane transporter activity 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0043425 bHLH transcription factor binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0047498 calcium-dependent phospholipase A2 activity 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0070717 poly-purine tract binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0071813 lipoprotein particle binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0071814 protein-lipid complex binding 1/755 32/18639 0.03125 0.77148178807947 0.734014945044484 0.926922946370236 GO:0003730 mRNA 3'-UTR binding 9/755 262/18639 0.0343511450381679 0.848041049491937 0.738923369502808 0.931896795396586 GO:0046906 tetrapyrrole binding 5/755 152/18639 0.0328947368421053 0.812086092715232 0.742171786591094 0.934766824264799 GO:0019956 chemokine binding 1/755 33/18639 0.0303030303030303 0.748103552077062 0.744807588484663 0.93563410788727 GO:0030296 protein tyrosine kinase activator activity 1/755 33/18639 0.0303030303030303 0.748103552077062 0.744807588484663 0.93563410788727 GO:0003774 cytoskeletal motor activity 5/755 153/18639 0.0326797385620915 0.806778340475263 0.747309340210879 0.937551274076573 GO:0015020 glucuronosyltransferase activity 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.942482484481349 GO:0019825 oxygen binding 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.942482484481349 GO:0051427 hormone receptor binding 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.942482484481349 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/755 34/18639 0.0294117647058824 0.726100506427737 0.755162864776939 0.942482484481349 GO:0016500 protein-hormone receptor activity 2/755 67/18639 0.0298507462686567 0.736937827419195 0.760749104087875 0.944142759708543 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/755 67/18639 0.0298507462686567 0.736937827419195 0.760749104087875 0.944142759708543 GO:0008170 N-methyltransferase activity 3/755 98/18639 0.0306122448979592 0.755737261792134 0.764215175123623 0.944142759708543 GO:0042626 ATPase-coupled transmembrane transporter activity 3/755 98/18639 0.0306122448979592 0.755737261792134 0.764215175123623 0.944142759708543 GO:0015078 proton transmembrane transporter activity 6/755 185/18639 0.0324324324324324 0.800672990871666 0.764871207563662 0.944142759708543 GO:0004623 phospholipase A2 activity 1/755 35/18639 0.0285714285714286 0.705354777672658 0.765098475478009 0.944142759708543 GO:0034061 DNA polymerase activity 1/755 35/18639 0.0285714285714286 0.705354777672658 0.765098475478009 0.944142759708543 GO:0004175 endopeptidase activity 14/755 405/18639 0.0345679012345679 0.853392200147167 0.765295763492568 0.944142759708543 GO:0005525 GTP binding 13/755 378/18639 0.0343915343915344 0.849038158309681 0.765335285965614 0.944142759708543 GO:0030145 manganese ion binding 2/755 68/18639 0.0294117647058824 0.726100506427737 0.767932219570704 0.944920439190073 GO:1990841 promoter-specific chromatin binding 2/755 68/18639 0.0294117647058824 0.726100506427737 0.767932219570704 0.944920439190073 GO:0004033 aldo-keto reductase (NADPH) activity 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.950728967770531 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/755 36/18639 0.0277777777777778 0.685761589403973 0.774631406622607 0.950728967770531 GO:0016298 lipase activity 4/755 130/18639 0.0307692307692308 0.759612837493632 0.77718614329583 0.952647810851139 GO:0099106 ion channel regulator activity 5/755 160/18639 0.03125 0.77148178807947 0.781157233407544 0.954639565604883 GO:0016782 transferase activity, transferring sulphur-containing groups 2/755 70/18639 0.0285714285714286 0.705354777672658 0.781736730432673 0.954639565604883 GO:0031072 heat shock protein binding 4/755 131/18639 0.0305343511450382 0.753814266215055 0.782240713312526 0.954639565604883 GO:0030280 structural constituent of skin epidermis 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.954639565604883 GO:0042805 actinin binding 1/755 37/18639 0.027027027027027 0.667227492393055 0.783777957609004 0.954639565604883 GO:0003924 GTPase activity 11/755 331/18639 0.0332326283987915 0.820427762549769 0.789511394997419 0.959608304350277 GO:0005501 retinoid binding 1/755 38/18639 0.0263157894736842 0.649668874172185 0.792553768919895 0.959608304350277 GO:0019840 isoprenoid binding 1/755 38/18639 0.0263157894736842 0.649668874172185 0.792553768919895 0.959608304350277 GO:0043531 ADP binding 1/755 38/18639 0.0263157894736842 0.649668874172185 0.792553768919895 0.959608304350277 GO:0005253 monoatomic anion channel activity 3/755 103/18639 0.029126213592233 0.719050986947856 0.792850149483995 0.959608304350277 GO:0004177 aminopeptidase activity 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.970270071010002 GO:0015144 carbohydrate transmembrane transporter activity 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.970270071010002 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.970270071010002 GO:0071855 neuropeptide receptor binding 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.970270071010002 GO:0071949 FAD binding 1/755 40/18639 0.025 0.617185430463576 0.809052598414404 0.970270071010002 GO:0016874 ligase activity 5/755 167/18639 0.029940119760479 0.739144228100091 0.811398242380666 0.970270071010002 GO:0005201 extracellular matrix structural constituent 5/755 168/18639 0.0297619047619048 0.734744560075686 0.815433741521566 0.970270071010002 GO:0016247 channel regulator activity 5/755 168/18639 0.0297619047619048 0.734744560075686 0.815433741521566 0.970270071010002 GO:0001530 lipopolysaccharide binding 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0004812 aminoacyl-tRNA ligase activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0017080 sodium channel regulator activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0140318 protein transporter activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0140828 metal cation:monoatomic cation antiporter activity 1/755 41/18639 0.024390243902439 0.602132127281538 0.816803837093748 0.970270071010002 GO:0098631 cell adhesion mediator activity 2/755 76/18639 0.0263157894736842 0.649668874172185 0.818907854631655 0.9710181423583 GO:0140767 enzyme-substrate adaptor activity 4/755 139/18639 0.0287769784172662 0.710429272476059 0.819454436475111 0.9710181423583 GO:0141108 transporter regulator activity 5/755 170/18639 0.0294117647058824 0.726100506427737 0.823297079149036 0.971953187610292 GO:0004520 DNA endonuclease activity 1/755 42/18639 0.0238095238095238 0.587795648060549 0.824240825102901 0.971953187610292 GO:0019001 guanyl nucleotide binding 13/755 400/18639 0.0325 0.802341059602649 0.82821666734982 0.971953187610292 GO:0032561 guanyl ribonucleotide binding 13/755 400/18639 0.0325 0.802341059602649 0.82821666734982 0.971953187610292 GO:0005245 voltage-gated calcium channel activity 1/755 43/18639 0.0232558139534884 0.574125981826582 0.831376286577725 0.971953187610292 GO:0016835 carbon-oxygen lyase activity 2/755 79/18639 0.0253164556962025 0.624997904266913 0.835281086005208 0.971953187610292 GO:0019205 nucleobase-containing compound kinase activity 1/755 44/18639 0.0227272727272727 0.561077664057797 0.838222431105248 0.971953187610292 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/755 44/18639 0.0227272727272727 0.561077664057797 0.838222431105248 0.971953187610292 GO:0004721 phosphoprotein phosphatase activity 5/755 175/18639 0.0285714285714286 0.705354777672658 0.841774193552395 0.971953187610292 GO:0046915 transition metal ion transmembrane transporter activity 1/755 45/18639 0.0222222222222222 0.548609271523179 0.844790974504847 0.971953187610292 GO:0033192 calmodulin-dependent protein phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0140791 histone H2AXS140 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/755 81/18639 0.0246913580246914 0.609565857247976 0.845441147883183 0.971953187610292 GO:0033549 MAP kinase phosphatase activity 2/755 82/18639 0.024390243902439 0.602132127281538 0.850304821128799 0.971953187610292 GO:0004180 carboxypeptidase activity 1/755 46/18639 0.0217391304347826 0.536682983011805 0.851093158771214 0.971953187610292 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/755 46/18639 0.0217391304347826 0.536682983011805 0.851093158771214 0.971953187610292 GO:0015085 calcium ion transmembrane transporter activity 4/755 147/18639 0.0272108843537415 0.671766454926341 0.851269097726676 0.971953187610292 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/755 268/18639 0.0298507462686567 0.736937827419195 0.854506568432412 0.971953187610292 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/755 83/18639 0.0240963855421687 0.594877523338387 0.855028746647655 0.971953187610292 GO:0001784 phosphotyrosine residue binding 1/755 47/18639 0.0212765957446809 0.525264196139214 0.857139771212872 0.971953187610292 GO:0061749 forked DNA-dependent helicase activity 1/755 47/18639 0.0212765957446809 0.525264196139214 0.857139771212872 0.971953187610292 GO:0140359 ABC-type transporter activity 1/755 47/18639 0.0212765957446809 0.525264196139214 0.857139771212872 0.971953187610292 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/755 47/18639 0.0212765957446809 0.525264196139214 0.857139771212872 0.971953187610292 GO:1990782 protein tyrosine kinase binding 3/755 117/18639 0.0256410256410256 0.63301069791136 0.857942953424976 0.971953187610292 GO:0017018 myosin phosphatase activity 2/755 84/18639 0.0238095238095238 0.587795648060549 0.859616246988753 0.971953187610292 GO:0009378 four-way junction helicase activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.971953187610292 GO:0036121 double-stranded DNA helicase activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.971953187610292 GO:0038187 pattern recognition receptor activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.971953187610292 GO:0043138 3'-5' DNA helicase activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.971953187610292 GO:0140693 molecular condensate scaffold activity 1/755 48/18639 0.0208333333333333 0.51432119205298 0.862941162818631 0.971953187610292 GO:0016791 phosphatase activity 8/755 273/18639 0.0293040293040293 0.723440797612983 0.867658882872236 0.971953187610292 GO:0005004 GPI-linked ephrin receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0005008 hepatocyte growth factor receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0005009 insulin receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0005011 macrophage colony-stimulating factor receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0005020 stem cell factor receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0008288 boss receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0036332 placental growth factor receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0038062 protein tyrosine kinase collagen receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0060175 brain-derived neurotrophic factor receptor activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0060590 ATPase regulator activity 1/755 49/18639 0.0204081632653061 0.503824841194756 0.868507265883121 0.971953187610292 GO:0008081 phosphoric diester hydrolase activity 2/755 87/18639 0.0229885057471264 0.567526832610185 0.872592816946271 0.971953187610292 GO:0015108 chloride transmembrane transporter activity 3/755 121/18639 0.0247933884297521 0.612084724426687 0.872913835796004 0.971953187610292 GO:0005006 epidermal growth factor receptor activity 1/755 50/18639 0.02 0.493748344370861 0.873847610921219 0.971953187610292 GO:0005007 fibroblast growth factor receptor activity 1/755 50/18639 0.02 0.493748344370861 0.873847610921219 0.971953187610292 GO:0005017 platelet-derived growth factor receptor activity 1/755 50/18639 0.02 0.493748344370861 0.873847610921219 0.971953187610292 GO:0005019 platelet-derived growth factor beta-receptor activity 1/755 50/18639 0.02 0.493748344370861 0.873847610921219 0.971953187610292 GO:0005010 insulin-like growth factor receptor activity 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.973715128677706 GO:0005021 vascular endothelial growth factor receptor activity 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.973715128677706 GO:0005030 neurotrophin receptor activity 1/755 51/18639 0.0196078431372549 0.484067004285158 0.87897134290005 0.973715128677706 GO:0001217 DNA-binding transcription repressor activity 8/755 278/18639 0.0287769784172662 0.710429272476059 0.879827756562433 0.973715128677706 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/755 52/18639 0.0192307692307692 0.47475802343352 0.883887236816042 0.973715128677706 GO:0004864 protein phosphatase inhibitor activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0005003 ephrin receptor activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0005005 transmembrane-ephrin receptor activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0005246 calcium channel regulator activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0008146 sulfotransferase activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0038064 collagen receptor activity 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0051018 protein kinase A binding 1/755 53/18639 0.0188679245283019 0.465800324878171 0.888603712643442 0.973715128677706 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/755 54/18639 0.0185185185185185 0.457174392935982 0.893128849679609 0.976446899365307 GO:0050661 NADP binding 1/755 54/18639 0.0185185185185185 0.457174392935982 0.893128849679609 0.976446899365307 GO:0001653 peptide receptor activity 3/755 128/18639 0.0234375 0.578611341059603 0.895777334253196 0.978229566156047 GO:0098632 cell-cell adhesion mediator activity 1/755 55/18639 0.0181818181818182 0.448862131246237 0.897470400311404 0.978651250288523 GO:0008083 growth factor activity 4/755 162/18639 0.0246913580246914 0.609565857247976 0.898200210982807 0.978651250288523 GO:0019212 phosphatase inhibitor activity 1/755 56/18639 0.0178571428571429 0.440846736045412 0.901635803226002 0.979439899122947 GO:0170055 lipid transmembrane transporter activity 1/755 56/18639 0.0178571428571429 0.440846736045412 0.901635803226002 0.979439899122947 GO:0004867 serine-type endopeptidase inhibitor activity 2/755 95/18639 0.0210526315789474 0.519735099337748 0.901981592844753 0.979439899122947 GO:0005262 calcium channel activity 3/755 131/18639 0.0229007633587786 0.565360699661291 0.904391789318445 0.980948656360074 GO:0015103 inorganic anion transmembrane transporter activity 4/755 165/18639 0.0242424242424242 0.59848284166165 0.905846651029504 0.981418975918098 GO:0017116 single-stranded DNA helicase activity 1/755 58/18639 0.0172413793103448 0.425645124457639 0.909466427708009 0.981684245902726 GO:0016829 lyase activity 5/755 200/18639 0.025 0.617185430463576 0.911744612869497 0.981684245902726 GO:0001786 phosphatidylserine binding 1/755 59/18639 0.0169491525423729 0.418430800314289 0.913145069712231 0.981684245902726 GO:0004879 nuclear receptor activity 1/755 59/18639 0.0169491525423729 0.418430800314289 0.913145069712231 0.981684245902726 GO:0015459 potassium channel regulator activity 1/755 59/18639 0.0169491525423729 0.418430800314289 0.913145069712231 0.981684245902726 GO:0045309 protein phosphorylated amino acid binding 1/755 59/18639 0.0169491525423729 0.418430800314289 0.913145069712231 0.981684245902726 GO:0015297 antiporter activity 3/755 135/18639 0.0222222222222222 0.548609271523179 0.914875969154199 0.981684245902726 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.981684245902726 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.981684245902726 GO:0098531 ligand-modulated transcription factor activity 1/755 60/18639 0.0166666666666667 0.411456953642384 0.916674427751374 0.981684245902726 GO:0140789 histone phosphatase activity 3/755 136/18639 0.0220588235294118 0.544575379820803 0.917328254756137 0.981684245902726 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/755 61/18639 0.0163934426229508 0.404711757681034 0.92006055224934 0.983513004128605 GO:0008238 exopeptidase activity 2/755 102/18639 0.0196078431372549 0.484067004285158 0.922379765704176 0.983703090932312 GO:0008514 organic anion transmembrane transporter activity 7/755 269/18639 0.0260223048327138 0.642423496393313 0.922802781690146 0.983703090932312 GO:0015179 L-amino acid transmembrane transporter activity 1/755 62/18639 0.0161290322580645 0.398184148686178 0.923309248721067 0.983703090932312 GO:0042578 phosphoric ester hydrolase activity 10/755 363/18639 0.0275482093663912 0.680094138251875 0.92617321096934 0.985661634265267 GO:0004536 DNA nuclease activity 1/755 64/18639 0.015625 0.385740894039735 0.929416414105612 0.988018997738377 GO:0038024 cargo receptor activity 1/755 65/18639 0.0153846153846154 0.379806418746816 0.932285356627833 0.989973732286572 GO:0008235 metalloexopeptidase activity 1/755 66/18639 0.0151515151515152 0.374051776038531 0.93503783620929 0.991800618760627 GO:0003777 microtubule motor activity 1/755 68/18639 0.0147058823529412 0.363050253213868 0.940212102261394 0.995092324089427 GO:0140223 general transcription initiation factor activity 1/755 68/18639 0.0147058823529412 0.363050253213868 0.940212102261394 0.995092324089427 GO:0008509 monoatomic anion transmembrane transporter activity 3/755 149/18639 0.0201342281879195 0.497062091648518 0.94383700914977 0.997829885360758 GO:0046943 carboxylic acid transmembrane transporter activity 4/755 188/18639 0.0212765957446809 0.525264196139214 0.9493874109389 0.999804654935738 GO:0005342 organic acid transmembrane transporter activity 4/755 189/18639 0.0211640211640212 0.522485020498266 0.950775430740715 0.999804654935738 GO:0003678 DNA helicase activity 1/755 74/18639 0.0135135135135135 0.333613746196528 0.953393348816709 0.999804654935738 GO:0045182 translation regulator activity 9/755 356/18639 0.0252808988764045 0.624120098221594 0.954424666722221 0.999804654935738 GO:0005085 guanyl-nucleotide exchange factor activity 5/755 230/18639 0.0217391304347826 0.536682983011805 0.958740174860201 0.999804654935738 GO:0019199 transmembrane receptor protein kinase activity 1/755 78/18639 0.0128205128205128 0.31650534895568 0.96052539331116 0.999804654935738 GO:0008528 G protein-coupled peptide receptor activity 2/755 122/18639 0.0163934426229508 0.404711757681034 0.960806652374672 0.999804654935738 GO:0022804 active transmembrane transporter activity 12/755 457/18639 0.0262582056892779 0.648247279261524 0.961272043930872 0.999804654935738 GO:0000049 tRNA binding 1/755 80/18639 0.0125 0.308592715231788 0.963671554396129 0.999804654935738 GO:0001618 virus receptor activity 1/755 81/18639 0.0123456790123457 0.304782928623988 0.965149434477541 0.999804654935738 GO:0015101 organic cation transmembrane transporter activity 1/755 81/18639 0.0123456790123457 0.304782928623988 0.965149434477541 0.999804654935738 GO:0140272 exogenous protein binding 1/755 82/18639 0.0121951219512195 0.301066063640769 0.966567269210242 0.999804654935738 GO:0042826 histone deacetylase binding 2/755 127/18639 0.015748031496063 0.388778223914064 0.967070695692883 0.999804654935738 GO:0030165 PDZ domain binding 1/755 83/18639 0.0120481927710843 0.297438761669193 0.967927495095151 0.999804654935738 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/755 130/18639 0.0153846153846154 0.379806418746816 0.9703543362471 0.999804654935738 GO:0005179 hormone activity 2/755 132/18639 0.0151515151515152 0.374051776038531 0.97236562556257 0.999804654935738 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/755 89/18639 0.0112359550561798 0.277386710320708 0.975003557434367 0.999804654935738 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/755 89/18639 0.0112359550561798 0.277386710320708 0.975003557434367 0.999804654935738 GO:0099094 ligand-gated monoatomic cation channel activity 2/755 136/18639 0.0147058823529412 0.363050253213868 0.97600054027993 0.999804654935738 GO:0140793 histone H2AXY142 phosphatase activity 1/755 90/18639 0.0111111111111111 0.274304635761589 0.976020932859545 0.999804654935738 GO:0052689 carboxylic ester hydrolase activity 1/755 92/18639 0.0108695652173913 0.268341491505903 0.977933296469266 0.999804654935738 GO:0070851 growth factor receptor binding 2/755 139/18639 0.0143884892086331 0.355214636238029 0.978418813335306 0.999804654935738 GO:0051219 phosphoprotein binding 1/755 93/18639 0.010752688172043 0.265456099124119 0.978831574420725 0.999804654935738 GO:0022843 voltage-gated monoatomic cation channel activity 2/755 143/18639 0.013986013986014 0.345278562497106 0.981278911912062 0.999804654935738 GO:0004725 protein tyrosine phosphatase activity 1/755 98/18639 0.0102040816326531 0.251912420597378 0.982803932542611 0.999804654935738 GO:0005249 voltage-gated potassium channel activity 1/755 98/18639 0.0102040816326531 0.251912420597378 0.982803932542611 0.999804654935738 GO:0015293 symporter activity 2/755 146/18639 0.0136986301369863 0.338183797514288 0.983179159934481 0.999804654935738 GO:0046982 protein heterodimerization activity 8/755 369/18639 0.021680216802168 0.535228557583589 0.983912888776985 0.999804654935738 GO:0015171 amino acid transmembrane transporter activity 1/755 102/18639 0.00980392156862745 0.242033502142579 0.9854385806285 0.999804654935738 GO:0004497 monooxygenase activity 1/755 106/18639 0.00943396226415094 0.232900162439085 0.987670020217533 0.999804654935738 GO:0005516 calmodulin binding 3/755 207/18639 0.0144927536231884 0.357788655341204 0.991110159569007 0.999804654935738 GO:0035401 histone H3Y41 kinase activity 1/755 115/18639 0.00869565217391304 0.214673193204722 0.991520678311547 0.999804654935738 GO:0140801 histone H2AXY142 kinase activity 1/755 115/18639 0.00869565217391304 0.214673193204722 0.991520678311547 0.999804654935738 GO:0015291 secondary active transmembrane transporter activity 5/755 287/18639 0.0174216027874564 0.43009437662967 0.991534762102632 0.999804654935738 GO:0015294 solute:monoatomic cation symporter activity 1/755 116/18639 0.00862068965517241 0.212822562228819 0.99186627795929 0.999804654935738 GO:0030371 translation repressor activity 6/755 329/18639 0.0182370820668693 0.450226453833612 0.992656455598183 0.999804654935738 GO:0005244 voltage-gated monoatomic ion channel activity 2/755 173/18639 0.0115606936416185 0.285403667266394 0.993668595857455 0.999804654935738 GO:0022832 voltage-gated channel activity 2/755 175/18639 0.0114285714285714 0.282141911069063 0.994115878407266 0.999804654935738 GO:0005267 potassium channel activity 1/755 124/18639 0.00806451612903226 0.199092074343089 0.994169857446741 0.999804654935738 GO:0015276 ligand-gated monoatomic ion channel activity 2/755 186/18639 0.010752688172043 0.265456099124119 0.996074949407631 0.999804654935738 GO:0022834 ligand-gated channel activity 2/755 188/18639 0.0106382978723404 0.262632098069607 0.9963547293026 0.999804654935738 GO:0004713 protein tyrosine kinase activity 1/755 140/18639 0.00714285714285714 0.176338694418165 0.99700589264985 0.999804654935738 GO:0005216 monoatomic ion channel activity 8/755 448/18639 0.0178571428571429 0.440846736045412 0.997929387256226 0.999804654935738 GO:0005261 monoatomic cation channel activity 5/755 341/18639 0.0146627565982405 0.361985589714707 0.99833672056761 0.999804654935738 GO:0015079 potassium ion transmembrane transporter activity 1/755 160/18639 0.00625 0.154296357615894 0.998699402352241 0.999804654935738 GO:0022836 gated channel activity 4/755 318/18639 0.0125786163522013 0.31053354991878 0.999085202552308 0.999804654935738 GO:0004252 serine-type endopeptidase activity 1/755 176/18639 0.00568181818181818 0.140269416014449 0.999332954937082 0.999804654935738 GO:0008236 serine-type peptidase activity 1/755 194/18639 0.00515463917525773 0.127254727930634 0.999685506252375 0.999804654935738 GO:0017171 serine hydrolase activity 1/755 198/18639 0.00505050505050505 0.124683925346177 0.999733925852748 0.999804654935738 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 7/755 484/18639 0.0144628099173554 0.357049422582234 0.999758156863556 0.999804654935738 GO:0046873 metal ion transmembrane transporter activity 6/755 450/18639 0.0133333333333333 0.329165562913907 0.999803454117616 0.999804654935738 GO:0001216 DNA-binding transcription activator activity 7/755 491/18639 0.0142566191446029 0.351959104948679 0.999804654935738 0.999804654935738