category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/402	238/9376	4.70387558008278	RPL13A/RPS27/RPS8/RPS28/RPL10/RPL37A/RPS26/RPL36/RPL28/RPL18A/RPS11/RPS20/RPS15/C1QB/RPL31/C1QA/RPL27A/RPS17/PLCG2/RPL7/RPS14/RPL11/RPL23/RPL8/RPL35/RPS29/RPLP2/RPS9/RPS5/RPLP0/RPL41/RPL13/RPL21/RPS2/RPS16/VWF/RPL34/RPL18/C1QC/EGFR/CYBB/RPL29/RPL12/UBA52/RPS27A/C5AR1/FCGR2A/RPS19	12.249685066025
Genetic Information Processing	Translation	hsa03010	Ribosome	40/402	222/9376	4.20241136659047	RPL13A/RPS27/RPS8/RPS28/RPL10/RPL37A/RPS26/RPL36/RPL28/RPL18A/RPS11/RPS20/RPS15/RPL31/RPL27A/RPS17/RPL7/RPS14/RPL11/RPL23/RPL8/RPL35/RPS29/RPLP2/RPS9/RPS5/RPLP0/RPL41/RPL13/RPL21/MRPS18A/RPS2/RPS16/RPL34/RPL18/RPL29/RPL12/UBA52/RPS27A/RPS19	10.2200679642688
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	39/402	275/9376	3.30767978290366	MT-CO2/MT-ND3/C1QB/C1QA/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/CCL5/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/CYBA/PSMA7/PSMC3/PSMC1/ATP5F1E/MT-ND6/C1QC/NDUFB10/CREB3L1/CYBB/NDUFS7/NDUFS8/ATF4/COX4I1/MT-ND4L/NDUFB1/NDUFA13/PSMD1/TUBA4A/NDUFA1/TUBB4B/UQCRB/UQCRC1	8.22058959830019
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	41/402	308/9376	3.10473605995994	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/AP2B1/MT-CO3/MT-ND2/POLR2I/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/GPX3/PSMA7/PSMC3/PSMC1/ATP5F1E/MT-ND6/NDUFB10/CREB3L1/ULK1/HIP1/NDUFS7/NDUFS8/AP2S1/COX4I1/MT-ND4L/AP2A2/NDUFB1/NDUFA13/PSMD1/TUBA4A/NDUFA1/TUBB4B/UQCRB/RB1CC1/SIN3A/UQCRC1	7.94918998037536
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/402	138/9376	4.39426058115221	MT-CO2/ATP5ME/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/ATP5F1E/MT-ND6/NDUFB10/NDUFS7/NDUFS8/COX4I1/MT-ND4L/NDUFB1/NDUFA13/NDUFA1/UQCRB/UQCRC1	8.50161388598789
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/402	205/9376	3.64072321320228	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/CTSD/TGFBR1/GAPDH/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/CYBA/ATP5F1E/TGFB1/MT-ND6/NDUFB10/CYBB/NDUFS7/NDUFS8/COX4I1/SLC2A1/MT-ND4L/NDUFB1/NDUFA13/NDUFA1/UQCRB/UQCRC1	8.09090494718285
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/402	268/9376	3.22001930645281	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/MAOA/PSMA7/PSMC3/UBA1/PSMC1/ATP5F1E/MT-ND6/NDUFB10/NDUFS7/NDUFS8/UBA52/ATF4/COX4I1/NFE2L2/MT-ND4L/NDUFB1/NDUFA13/PSMD1/RPS27A/TUBA4A/NDUFA1/TUBB4B/UQCRB/UQCRC1	7.80401812723293
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/402	227/9376	3.18513161066912	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/ATP5F1D/GSTA1/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/CYBA/ATP5F1E/MT-ND6/NDUFB10/EGFR/NDUFS7/NDUFS8/COX4I1/HMOX1/NFE2L2/MT-ND4L/VEGFA/NDUFB1/NDUFA13/NDUFA1/UQCRB/UQCRC1	7.05357594388301
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/402	235/9376	2.97745315973325	MT-CO2/ATP5ME/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/BMP8B/ATP5F1D/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/PNPLA2/ATP5F1E/MT-ND6/NDUFB10/CREB3L1/NDUFAF2/NDUFS7/NDUFS8/COX4I1/MT-ND4L/NDUFB1/NDUFA13/NDUFA1/UQCRB/UQCRC1	6.49753928363951
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/402	155/9376	3.46088910287273	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/DYNC1I2/HLA-DRB5/HLA-DPA1/CD14/MRC2/CYBA/HLA-G/HLA-DQA1/HLA-DPB1/CYBB/ITGB2/HLA-DMB/FCGR3A/FCGR2A/TUBA4A/MSR1/MRC1/TUBB4B/HLA-DMA	6.5384455794074
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/402	100/9376	4.19820895522388	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CD14/CD59/HLA-DQA1/IL1R2/HLA-DPB1/HLA-DMB/CSF1R/IL7R/CD3E/CD3D/CD34/CD7/CD37/HLA-DMA	6.80506216930465
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/402	39/9376	6.57839010077816	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA	7.38827645901165
Human Diseases	Immune disease	hsa05310	Asthma	10/402	32/9376	7.28855721393035	HLA-DRA/HLA-DRB1/PRG2/HLA-DRB5/HLA-DPA1/FCER1G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA	7.5416300222239
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	39/402	388/9376	2.34436067087244	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/GAPDH/ATP5F1D/APOE/MT-ND5/NDUFA3/MT-ND4/IRS2/MT-ATP8/PSMA7/PSMC3/PSMC1/ATP5F1E/MT-ND6/NDUFB10/ULK1/CYBB/NDUFS7/NDUFS8/ATF4/COX4I1/MT-ND4L/NDUFB1/NDUFA13/PSMD1/WNT10B/TUBA4A/NDUFA1/TUBB4B/UQCRB/RB1CC1/UQCRC1	5.72408088257705
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/402	99/9376	4.00502537815971	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DRB5/HLA-DPA1/KRT18/HLA-DQA1/KRT19/C1QC/HLA-DPB1/ITGB2/HLA-DMB/FCGR3A/C5AR1/FCGR2A/HLA-DMA	6.36161811737917
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	37/402	368/9376	2.34501406013411	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/ATP5F1D/MAP1LC3A/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/GPX3/PSMA7/PSMC3/PSMC1/ATP5F1E/TNFRSF1B/MT-ND6/NDUFB10/ULK1/NDUFS7/NDUFS8/ATF4/COX4I1/MT-ND4L/NDUFB1/NDUFA13/PSMD1/TUBA4A/NDUFA1/TUBB4B/UQCRB/RB1CC1/UQCRC1	5.57111568829402
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/402	44/9376	5.83084577114428	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA	6.79779052834775
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/402	45/9376	5.70127142067441	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA	6.69057001067235
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/402	95/9376	3.92814873003404	HLA-DRA/FLT1/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL5/CCL3/HLA-DQA1/TGFB1/ACP5/HLA-DPB1/ITGB2/HLA-DMB/LTB/VEGFA/HLA-DMA	6.07104120645001
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	43/402	480/9376	2.0893864013267	MT-CO2/MT-ND3/COX7A1/MT-CYB/MT-ND1/MT-ATP6/MT-CO3/MT-ND2/ATP5F1D/MAP1LC3A/MT-ND5/NDUFA3/MT-ND4/MT-ATP8/GPX3/PSMA7/PSMC3/UBA1/PSMC1/ATP5F1E/TNFRSF1B/MT-ND6/NDUFB10/ULK1/CYBB/HIP1/NDUFS7/NDUFS8/UBA52/ATF4/COX4I1/MT-ND4L/NDUFB1/NDUFA13/PSMD1/RPS27A/WNT10B/TUBA4A/NDUFA1/TUBB4B/UQCRB/RB1CC1/UQCRC1	5.18574089431722
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/402	78/9376	4.18624824594974	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CYBA/HLA-DQA1/TGFB1/HLA-DPB1/CYBB/ITGB2/HLA-DMB/FCGR3A/FCGR2A/HLA-DMA	5.98050381780215
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/402	205/9376	2.73054240990171	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/NCOR2/PLCG2/HLA-DRB5/HLA-DPA1/TAPBP/PSMC3/PSMC1/HLA-G/HLA-DQA1/LYN/RBPJ/HLA-DPB1/RUNX3/CDKN1A/HLA-DMB/CD3E/PSMD1/CD3D/SIN3A/HLA-DMA	5.30220436416141
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/402	82/9376	3.98204101444	CD74/HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/TAPBP/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/PSME1/HLA-DMA	5.74017108434607
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/402	224/9376	2.60305614783227	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFBR1/HLA-G/HLA-DQA1/TLN1/TGFB1/CREB3L1/IL1R2/HLA-DPB1/ITGB2/CDKN1A/HLA-DMB/ATF4/SLC2A1/IL2RG/CD3E/SPI1/CD3D/ANAPC11/HLA-DMA	5.13949407334687
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/402	54/9376	4.75105951722867	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/HLA-DMA	5.85062035540371
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/402	70/9376	3.99829424307036	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-G/HLA-DQA1/HLA-DPB1/ITGB2/HLA-DMB/HLA-DMA	5.32902035302127
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/402	50/9376	4.66467661691542	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/TGFB1/CXCR4/HLA-DPB1/HLA-DMB/HLA-DMA	5.49893499624881
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/402	93/9376	3.26025785053228	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/RBPJ/HLA-DPB1/RUNX3/HLA-DMB/IL2RG/CD3E/CD3D/HLA-DMA	4.6361867084231
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/402	160/9376	2.62388059701493	HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/CLDN5/HLA-G/HLA-DQA1/PECAM1/PTPRC/HLA-DPB1/ITGB2/HLA-DMB/GLG1/ICAM2/CD34/HLA-DMA	4.38478681444844
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/402	109/9376	2.99566388242275	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFBR1/HLA-DQA1/TGFB1/HLA-DPB1/HLA-DMB/IL2RG/EBI3/CD3E/CD3D/HLA-DMA	4.43543988134295
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/402	181/9376	2.44831093153019	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/CTSD/CD14/MRC2/FCER1G/LSP1/HLA-DQA1/TGFB1/HLA-DPB1/ITGB2/HLA-DMB/FCGR3A/FCGR2A/MRC1/HLA-DMA	4.16419311186636
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/402	88/9376	3.18046132971506	CLU/C1QB/C1QA/SERPINE2/CD59/VWF/C1QC/A2M/ITGB2/C5AR1/F10/SERPING1	4.34944910938099
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/402	157/9376	2.52546186266122	MT-CO2/COX7A1/MT-CYB/MT-CO3/NDUFA3/IRS2/TGFB1/NDUFB10/NDUFS7/NDUFS8/ATF4/COX4I1/NDUFB1/NDUFA13/NDUFA1/UQCRB/UQCRC1	4.07957484652555
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/402	203/9376	2.29787025463814	FN1/FLT1/MYL9/SPP1/KDR/PIP5K1C/FLNA/VWF/TLN1/EGFR/EMP2/ACTN4/VEGFA/MYLK3/ZYX/TNXB/ROCK1/COL6A3/PPP1R12A/PAK4	3.95666456430554
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/402	298/9376	2.03492604093626	TNFSF10/IL1RL1/BMP8B/TGFBR1/CCL5/CCL21/CCL4/PRLR/TNFRSF11B/CXCL14/CCL3/INHA/TGFB1/TNFRSF1B/BMP4/CXCR4/IL1R2/IL32/TNFRSF21/CSF1R/LTB/IL7R/IL2RG/EBI3/INHBB/CCL18	3.84262487523373
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/402	66/9376	3.53384592190562	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/TGFB1/HLA-DPB1/HLA-DMB/IL2RG/HLA-DMA	4.37202827720474
NA	NA	hsa04518	Integrin signaling	16/402	154/9376	2.42320863216386	FN1/FLT1/SPP1/KDR/LIMS2/FLNA/VWF/TLN1/TGFB1/EGFR/ITGB2/ACTN4/VEGFA/ICAM2/TNXB/COL6A3	3.76896411804983
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/402	116/9376	2.61382741465088	MYL9/PLCG2/THY1/CYBA/EZR/CLDN5/PECAM1/CXCR4/CYBB/ITGB2/ACTN4/PTK2B/ROCK1	3.70157217706396
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/402	143/9376	2.2834081341544	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/C1QC/HLA-DPB1/HLA-DMB/ACTN4/FCGR3A/FCGR2A/HLA-DMA	3.27315838257558
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/402	100/9376	2.56557213930348	TNFSF10/CCL5/CCL21/CCL4/CXCL14/CCL3/TNFRSF1B/CXCR4/CSF1R/IL2RG/CCL18	3.33118188575196
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/402	149/9376	2.19145881331597	MT-ND3/MT-ND1/MT-ND2/MT-ND5/NDUFA3/MT-ND4/MT-ND6/NDUFB10/NDUFS7/NDUFS8/MT-ND4L/NDUFB1/NDUFA13/NDUFA1	3.10275540030733
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/402	110/9376	2.33233830845771	FLT1/PLCG2/ELOB/GAPDH/EGFR/CYBB/CDKN1A/HMOX1/SLC2A1/VEGFA/EPAS1	2.97488609707381
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/402	142/9376	2.13523929647537	PLCG2/TYROBP/TGFBR1/FOSB/TNFRSF11B/CYBA/TGFB1/ACP5/CSF1R/FCGR3A/FCGR2A/SPI1/FOSL2	2.8849765345959
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/402	180/9376	1.94361525704809	CD74/HLA-DRA/HLA-E/HLA-A/HLA-DRB1/HLA-DRB5/HLA-DPA1/CCL5/TAPBP/HLA-G/HLA-DQA1/HLA-DPB1/HLA-DMB/EIF2B4/HLA-DMA	2.70543657912366
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/402	133/9376	2.10436539108966	HLA-E/HLA-A/PLCG2/TYROBP/TNFSF10/FCER1G/HLA-G/ITGB2/HCST/FCGR3A/PTK2B/ICAM2	2.71479952322182
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/402	87/9376	2.41276376737005	MT-CO2/COX7A1/MT-CYB/MT-CO3/TPM1/COX4I1/TPM3/UQCRB/UQCRC1	2.80188512244458
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/402	103/9376	2.26440612471622	C1QB/C1QA/TGFBR1/CCL5/CCL3/TGFB1/C1QC/CD3E/CFLAR/CD3D	2.73086798119458
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/402	106/9376	2.20031915892237	ZEB1/CREB3L1/IL1R2/TCF7L2/EGFR/CDKN1A/ATF4/FOLR2/KLK3/GSTP1	2.63036147953967
Organismal Systems	Immune system	hsa04611	Platelet activation	11/402	126/9376	2.03616836452657	PLCG2/RASGRP2/FCER1G/VWF/TLN1/LYN/VAMP8/MYLK3/FCGR2A/ROCK1/PPP1R12A	2.47827997066859
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/402	38/9376	3.06886619533909	PTPRC/IL7R/IL2RG/CD3E/CD3D	2.70459909936483
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/402	204/9376	1.71495463857185	FN1/KDR/PLCG2/IQGAP1/FLNA/RDX/EZR/TIMP3/TGFB1/EGFR/CDKN1A/VEGFA/WNT10B/ROCK1/PPP1R12A	2.18507919018087
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/402	70/9376	2.33233830845771	ELOB/TGFB1/CDKN1A/SLC2A1/VEGFA/EPAS1/PAK4	2.36803241686191
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/402	42/9376	2.77659322435442	MAP1LC3A/GPX4/CYBB/HMOX1/PCBP2	2.442217733977
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/402	227/9376	1.64393889582922	HLA-E/HLA-A/CCL5/TAPBP/CCL4/AKAP13/CCL3/HLA-G/CREB3L1/CXCR4/EGFR/CDKN1A/ATF4/VEGFA/PTK2B/ROCK1	2.07862624053146
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/402	105/9376	1.99914712153518	MAP1LC3A/ATG9B/ULK1/UBA52/ATF4/GABARAPL1/RPS27A/FIS1/FKBP8	2.17904617219408
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/402	44/9376	2.65038444142922	DYNC1I2/ARHGDIA/ARHGDIB/CREB3L1/VAMP2	2.32236098098876
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/402	250/9376	1.58599004975124	HLA-E/HLA-A/AP2B1/RAB11FIP1/PIP5K1C/TGFBR1/EHD2/RAB31/ACAP1/DAB2/HLA-G/CXCR4/EGFR/AP2S1/IL2RG/AP2A2/FOLR2	1.98758470429683
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/402	142/9376	1.80674094317147	KDR/GSTA1/CYBA/MEF2A/BMP4/PECAM1/IL1R2/HMOX1/NFE2L2/VEGFA/GSTP1	2.05016572080752
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/402	233/9376	1.60160570537869	FN1/MYL9/TPM1/PLEC/SYNE2/PDLIM4/TLN1/FBN2/BGN/DSP/ZYX/LMOD1/FBLN1/TPM3/COL6A3/EMD	1.96811820716908
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/402	93/9376	2.00631252340448	MYL9/IQGAP1/TGFBR1/WASF2/TCF7L2/EGFR/ACTN4/ROCK1	2.06412411947994
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/402	46/9376	2.53515033528012	PSMA7/PSMC3/PSMC1/PSME1/PSMD1	2.20899451701142
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/402	110/9376	1.90827679782904	EMP3/BMP8B/TGFBR1/TGFB1/BMP4/LTBP1/INHBB/ROCK1/SIN3A	2.02802846769761
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/402	112/9376	1.87420042643923	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DQA1/TGFB1/HLA-DPB1/HLA-DMB/HLA-DMA	1.96981928187685
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/402	98/9376	1.90394963955732	PLCG2/PIP5K1C/WASF2/MYO10/LYN/PTPRC/FCGR3A/FCGR2A	1.9038631228856
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/402	169/9376	1.65609820718891	CTSD/MAP1LC3A/IRS2/ATG9B/ULK1/VAMP8/UBA52/GABARAPL1/MTMR3/RPS27A/CFLAR/RB1CC1	1.8216241023845
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/402	173/9376	1.61780691916142	HLA-DRA/HLA-DRB1/HLA-DRB5/TNFSF10/HLA-DPA1/CCL5/HLA-DQA1/HLA-DPB1/HLA-DMB/HNRNPUL1/KPNA6/HLA-DMA	1.73586817346123
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/402	52/9376	2.24263298890165	APOA1/APOE/PLTP/APOC3/APOC1	1.90173084445469
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/402	250/9376	1.49269651741294	AP2B1/PSAP/CTSD/TPP1/CD68/LAPTM5/CTSA/CTSZ/ACP5/VAMP8/CTSW/AP2S1/TTI1/AP2A2/BLOC1S1/LAMTOR4	1.67114793550842
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/402	232/9376	1.50797735460628	FN1/MYL9/IQGAP1/PIP5K1C/WASF2/RDX/EZR/CXCR4/EGFR/ITGB2/ACTN4/MYLK3/ROCK1/PPP1R12A/PAK4	1.65815783733995
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/402	157/9376	1.63412238172196	BMP8B/TGFBR1/YWHAE/TGFB1/BMP4/TCF7L2/FBXW11/ITGB2/NKD2/WNT10B/DLG5	1.6958468654069
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/402	253/9376	1.47499655870843	MYL9/CBX3/PLCG2/CCL5/CAPNS1/CD14/MAP1LC3A/WASF2/CAST/TLN1/EGFR/FBXW11/UBA52/ACTN4/RPS27A/ROCK1	1.62101681001966
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/402	59/9376	1.97655788852348	GSTA1/GPX3/GPX4/PGD/GSTP1	1.59254452285178
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/402	170/9376	1.50916008194323	PLCG2/TGFBR1/GSTA1/TGFB1/TCF7L2/EGFR/CDKN1A/HMOX1/NFE2L2/WNT10B/GSTP1	1.41791094622198
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/402	78/9376	1.79410639112132	C1QB/C1QA/CD14/C1QC/ITGB2/SERPING1	1.49051672602068
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/402	193/9376	1.45015853375609	PLCG2/CCL5/CCL21/CCL4/RASGRP2/CXCL14/CCL3/LYN/CXCR4/PTK2B/ROCK1/CCL18	1.3373881847179
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/402	214/9376	1.41684102850235	HLA-E/HLA-A/PLCG2/ELOB/TAPBP/HLA-G/TNFRSF1B/CXCR4/FBXW11/CD3E/PTK2B/CD3D/PAK4	1.30553293962918
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/402	157/9376	1.48556580156542	C1QB/C1QA/MFGE8/TGFB1/BSG/C1QC/PECAM1/SLC2A1/STAB1/ATP8A2	1.29855886855379
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/402	16/9376	2.91542288557214	MIF/MAOA	1.62290228299011
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/402	200/9376	1.39940298507463	TNFSF10/GAPDH/WASF2/EZR/CLDN5/MYO10/MYO1C/FCGR2A/NCL/TUBA4A/ROCK1/TUBB4B	1.20838474485465
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/402	103/9376	1.58508428730136	FN1/HSPB1/CD14/TGFB1/IL1R2/ITGB2/ACTN4	1.2636667248428
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/402	49/9376	1.90394963955732	FOSB/MAOA/CREB3L1/ATF4	1.34269360266762
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/402	105/9376	1.55489220563847	PLCG2/CCL21/CCL4/CD14/LYN/LTB/CFLAR	1.21016786278583
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/402	50/9376	1.86587064676617	HBA2/TGFB1/PECAM1/ITGB2	1.2992596344653
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/402	68/9376	1.71495463857185	CD14/TCF7L2/CSF1R/SPI1/ZBTB16	1.25230579239231
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/402	33/9376	2.12030755314337	VAMP8/VAMP2/VTI1B	1.36444706560853
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/402	205/9376	1.36527120495086	HLA-E/HLA-A/YWHAE/CHD4/PSMC1/HLA-G/LYN/CREB3L1/RBPJ/CDKN1A/ATF4/ACTN4	1.11915348962926
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/402	90/9376	1.55489220563847	IRS2/CREB3L1/ULK1/ATF4/EHMT2/RB1CC1	1.11949245695187
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/402	53/9376	1.7602553271379	AP2B1/ATP2B4/AP2S1/AP2A2	1.17469520709123
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/402	73/9376	1.59749199209432	MAP1B/SUPT5H/CXCR4/MAP1A/PIN1	1.08464505533592
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/402	37/9376	1.89108511496571	TCF7L2/CDKN1A/TPM3	1.14941138776166
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/402	133/9376	1.40291026072644	TNFSF10/TGFBR1/IRS2/TGFB1/EGFR/CDKN1A/IL7R/GABARAPL1	0.990451704251674
NA	NA	hsa04517	IgSF CAM signaling	16/402	299/9376	1.24807401121483	MYL9/KDR/PLCG2/IQGAP1/RDX/EZR/LYN/ITGB2/CD84/ACTN4/MYLK3/ICAM2/PPFIA1/TUBA4A/TUBB4B/PAK4	0.922680468741457
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/402	174/9376	1.34042431520558	SIL1/SEC62/RRBP1/SSR4/PRKCSH/ATF4/NFE2L2/MAN1A2/ERP29/STUB1	0.959311640512649
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/402	196/9376	1.30896537719565	HLA-E/HLA-A/PLCG2/MAP1LC3A/HLA-G/LYN/TCF7L2/CDKN1A/UBA52/VEGFA/RPS27A	0.925171279111515
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/402	115/9376	1.41968418775687	AKAP13/MEF2A/CREB3L1/EGFR/NR4A2/CDKN1A/ATF4	0.95840311597168
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/402	21/9376	2.22127457948353	CHPF/CHSY1	1.18578704443014
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/402	77/9376	1.51450539510241	TGFBR1/TGFB1/EGFR/CDKN1A/VEGFA	0.959451009207288
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/402	22/9376	2.12030755314337	AOC1/MAOA	1.11341111831397
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/402	98/9376	1.42796222966799	KCNK3/ATP2B4/CYP11A1/CREB3L1/NR4A2/ATF4	0.901357190044121
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/402	201/9376	1.27640404940472	FLT1/HPGD/NUPR1/ZEB1/CD14/IL1R2/CDKN1A/CSF1R/SPI1/ZBTB16/SIN3A	0.838387946218698
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/402	79/9376	1.47616348636564	AP2B1/SYT1/AP2S1/AP2A2/VAMP2	0.899505559008273
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/402	60/9376	1.55489220563847	HSPB1/KDR/PLCG2/VEGFA	0.91258881559352
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/402	41/9376	1.70658900618857	EGFR/CDKN1A/VEGFA	0.959637642886347
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	17/402	333/9376	1.19068322053397	FN1/HLA-E/HLA-A/SPP1/CHD4/PSMC1/HLA-G/VWF/CREB3L1/TCF7L2/RBPJ/EGFR/CDKN1A/VEGFA/WNT10B/TNXB/COL6A3	0.74986651673677
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/402	142/9376	1.31399341321561	ELOB/UBA1/FBXW11/UBE2K/UBA52/RPS27A/ANAPC11/STUB1	0.797949500124944
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/402	101/9376	1.38554750997488	FN1/PLCG2/TGFBR1/TGFB1/CYBB/VEGFA	0.824493549987
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/402	166/9376	1.26452076964575	MYL9/IRS2/ATP2B4/MEF2A/CREB3L1/ATF4/MYLK3/ROCK1/PPP1R12A	0.727762441563683
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/402	63/9376	1.48084971965569	BMP4/TCF7L2/CDKN1A/WNT10B	0.810476585285133
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/402	65/9376	1.43528511289705	KCNK3/CYP11A1/CREB3L1/ATF4	0.745311738501094
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/402	26/9376	1.79410639112132	APOA1/TCN2	0.858153922676035
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/402	87/9376	1.34042431520558	TGFBR1/TGFB1/TCF7L2/EGFR/CDKN1A	0.675151675122954
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/402	27/9376	1.72765800626497	FADS1/TECR	0.801368461620324
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/402	130/9376	1.25587447378492	TGFBR1/RXFP1/TGFB1/CREB3L1/EGFR/ATF4/VEGFA	0.621766510279731
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/402	89/9376	1.31030242048186	FN1/SPP1/VWF/TNXB/COL6A3	0.622512499291245
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/402	69/9376	1.35208017881606	FOSB/MAOA/CREB3L1/ATF4	0.621250708003773
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/402	155/9376	1.20378751404269	KCNK3/CYP11A1/CREB3L1/TCF7L2/EGFR/CDKN1A/ATF4/WNT10B	0.541452099070779
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/402	157/9376	1.18845264125234	HLA-E/HLA-A/TGFBR1/HLA-G/TGFB1/FBXW11/CDKN1A/HIPK2	0.503982874847576
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/402	71/9376	1.31399341321561	PLCG2/CCL5/LYN/EGFR	0.562078735655132
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/402	50/9376	1.39940298507463	AOC1/MAOA/SMOX	0.59931374083472
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/402	137/9376	1.19170570505139	TNFSF10/CTSD/CTSZ/CTSW/ATF4/CFLAR/TUBA4A	0.478397024275943
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/402	248/9376	1.12855079441502	MYL9/DYNC1I2/AHNAK2/TNFSF10/GAPDH/AHNAK/CD14/FLNA/PTPRC/TCF7L2/TUBA4A/TUBB4B	0.434228597281823
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/402	138/9376	1.18307015646406	FN1/PIP5K1C/WASF2/FYB1/PTK2B/FCGR2A/ROCK1	0.458536328338253
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/402	73/9376	1.27799359367546	GSTA1/MAOA/CYP3A5/GSTP1	0.504650071941965
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	17/402	362/9376	1.09529699568456	FN1/FLT1/SPP1/KDR/PRLR/YWHAE/VWF/CREB3L1/EGFR/CDKN1A/CSF1R/ATF4/VEGFA/IL7R/IL2RG/TNXB/COL6A3	0.391363527575221
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/402	31/9376	1.50473439255336	H6PD/PGD	0.595744065377881
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/402	31/9376	1.50473439255336	SEC62/SRP14	0.595744065377881
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/402	32/9376	1.45771144278607	ATG9B/GABARAPL1	0.548916109212499
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/402	323/9376	1.0831292454138	PLCG2/TPM1/ZEB1/IRS2/RDX/EZR/TIMP3/EGFR/CDKN1A/HMOX1/VEGFA/TNXB/ROCK1/FOXP1/PAK4	0.321784018874081
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/402	144/9376	1.13377556661139	PSMA7/PSMC3/PSMC1/ULK1/RBPJ/PSMD1/RB1CC1	0.342385827450254
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/402	78/9376	1.19607092741421	PLCG2/PIP5K1C/TPI1/MTMR3	0.368019953075306
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/402	170/9376	1.09757096868598	MYL9/RDX/EZR/CLDN5/SYNPO/ACTN4/TUBA4A/ROCK1	0.27171600728268
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/402	216/9376	1.07978625391561	APOA1/TNFSF10/CCL5/CD14/CYBA/CCL3/LYN/CYBB/ATF4/NFE2L2	0.251080419540151
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/402	80/9376	1.16616915422886	KDR/PLCG2/EGFR/VEGFA	0.315902437920153
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/402	103/9376	1.13220306235811	SLC7A8/COL17A1/COL14A1/COL26A1/COL6A3	0.285532553941611
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/402	36/9376	1.29574350469873	GALNT6/GALNT15	0.376269190931489
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/402	59/9376	1.18593473311409	TCF7L2/EGFR/CDKN1A	0.303217396847265
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/402	37/9376	1.26072340997714	MIF/MAOA	0.336307330748431
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/402	37/9376	1.26072340997714	APOA1/HBA2	0.336307330748431
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/402	15/9376	1.55489220563847	ST3GAL5	0.455196342173907
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/402	61/9376	1.14705162711035	ATOX1/ATP2B4/HMOX1	0.243864708214041
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/402	154/9376	1.06015377657169	MYL9/EEF2/EGFR/CDKN1A/MYLK3/ROCK1/PPP1R12A	0.159300204017996
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/402	109/9376	1.06987995800812	SPP1/CCL5/CCL4/CD14/CCL3	0.155310899488509
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/402	86/9376	1.08480851556173	PLCG2/EGFR/CDKN1A/PAK4	0.167219323609495
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/402	86/9376	1.08480851556173	CREB3L1/ATF4/SLC2A1/VAMP2	0.167219323609495
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/402	63/9376	1.11063728974177	HPGD/PTGDS/GPX4	0.186480160286496
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/402	134/9376	1.04433058587659	MYL9/CALD1/RAMP1/MYLK3/ROCK1/PPP1R12A	0.109390226165612
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/402	300/9376	1.01067993366501	HSPB1/FLT1/KDR/TGFBR1/CD14/FLNA/RASGRP2/TGFB1/EGFR/CSF1R/ATF4/VEGFA/TAOK3	0.0397912489788183
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/402	42/9376	1.11063728974177	AOC1/MAOA	0.152089036107115
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/402	18/9376	1.29574350469873	TCN2	0.265806489293716
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/402	139/9376	1.00676473746376	CTSD/KRT18/KRT19/CREB3L1/EGFR/ATF4	0.0170058563784453
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	9/402	212/9376	0.990143621515066	FLT1/KDR/RASGRP2/TLN1/FYB1/EGFR/ITGB2/CSF1R/VEGFA	-0.0307219228636578
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/402	117/9376	0.996725772845176	BRD9/CHD4/ZNHIT1/BPTF/BRD8	-0.00754267381562376
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/402	93/9376	1.00315626170224	LYZ/ATP2B4/CST2/VAMP2	0.00647404832541143
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/402	69/9376	1.01406013411205	PLCG2/FCER1G/LYN	0.0248093155971197
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/402	119/9376	0.979974079183912	CCL5/TNFRSF1B/CREB3L1/ATF4/CFLAR	-0.0465303667438748
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/402	70/9376	0.999573560767591	IRS2/TNFRSF1B/SLC2A1	-0.000757932065569729
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/402	70/9376	0.999573560767591	GSTA1/CYP3A5/GSTP1	-0.000757932065569729
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/402	144/9376	0.971807628524046	C1QB/C1QA/CD14/C1QC/TCF7L2/C5AR1	-0.0721556909089377
NA	NA	hsa04382	Cornified envelope formation	9/402	217/9376	0.967329252355733	KRT8/KRT18/KRT7/PLEC/CLDN5/KRT19/COL17A1/DSP/PRSS8	-0.103055350008319
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/402	120/9376	0.971807628524046	PLCG2/YWHAE/ARHGDIA/ARHGDIB/ATF4	-0.0657833811108345
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/402	71/9376	0.985495059911709	SLC16A3/EGFR/SLC2A1	-0.0259652529079698
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/402	46/9376	1.01406013411205	BLVRB/HMOX1	0.0202317378618771
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/402	194/9376	0.961788993178438	MYL9/DYNC1I2/TPM1/MYO10/MYO1C/TPM3/TUBA4A/TUBB4B	-0.113822031843107
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/402	195/9376	0.956856741931369	PLCG2/CYBA/VWF/CYBB/ITGB2/FCGR3A/C5AR1/FCGR2A	-0.128851916636151
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/402	122/9376	0.955876355925292	PLCG2/BMP4/SLC2A1/DIO2/SIN3A	-0.103822665020012
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/402	73/9376	0.958495195256594	PLCG2/EGFR/CDKN1A	-0.0753449114519874
NA	NA	hsa03272	Virion - Hepatitis viruses	2/402	48/9376	0.971807628524046	CLDN5/EGFR	-0.0414441838269824
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/402	99/9376	0.942358912508166	PIP5K1C/WASF2/SLC44A2/EGFR	-0.122025786922988
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/402	99/9376	0.942358912508166	TPM1/TGFB1/TPM3/EMD	-0.122025786922988
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/402	150/9376	0.932935323383085	TGFBR1/TGFB1/TCF7L2/EGFR/CDKN1A/WNT10B	-0.175242068704923
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/402	49/9376	0.951974819778658	GALNT6/GALNT15	-0.0713348392746023
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/402	75/9376	0.932935323383085	GSTA1/CDKN1A/GSTP1	-0.123414240940266
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/402	75/9376	0.932935323383085	GPX3/CREB3L1/ATF4	-0.123414240940266
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/402	23/9376	1.01406013411205	PCYOX1	0.0142883982401651
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/402	23/9376	1.01406013411205	MLH3	0.0142883982401651
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/402	23/9376	1.01406013411205	CTSA	0.0142883982401651
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/402	76/9376	0.920659858601728	APOA1/PLTP/APOC3	-0.146981922687147
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/402	76/9376	0.920659858601728	PLCG2/EGFR/CDKN1A	-0.146981922687147
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/402	178/9376	0.917211694337302	NOTUM/TCF7L2/FBXW11/NKD2/TBL1X/SFRP1/WNT10B	-0.236014086786058
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/402	77/9376	0.908703237061446	TGFBR1/TGFB1/CDKN1A	-0.170250442799183
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/402	51/9376	0.914642473904985	PLD3/CEPT1	-0.129362416448548
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/402	79/9376	0.885698091819384	GSTA1/CYP3A5/GSTP1	-0.215924162094963
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/402	105/9376	0.888509831793414	TPM1/TGFB1/TPM3/EMD	-0.243149601326536
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/402	184/9376	0.887302617348042	SEMA3B/MYL9/DPYSL2/PLCG2/CXCR4/ROCK1/PAK4	-0.326755845526138
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/402	108/9376	0.863829003132486	UPF2/SRRM1/KPNA6/KPNB1	-0.301237555110117
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/402	82/9376	0.853294503094285	GSTA1/NME4/GSTP1	-0.282395395360098
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/402	55/9376	0.84812302125735	PSAP/CERK	-0.239082435964721
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/402	109/9376	0.8559039664065	IRS2/CREB3L1/SLC2A1/OGA	-0.320258987384207
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/402	238/9376	0.881976671265521	FLT1/KDR/PLCG2/RASGRP2/EGFR/CSF1R/VEGFA/SYNGAP1/PAK4	-0.390334009926164
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/402	56/9376	0.832977967306325	DPM3/MAN1A2	-0.265317229899388
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/402	56/9376	0.832977967306325	CD14/ITGB2	-0.265317229899388
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/402	163/9376	0.85852943869609	TGFBR1/TGFB1/CREB3L1/CDKN1A/ATF4/PTK2B	-0.385624817123699
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/402	28/9376	0.832977967306325	TECR	-0.187326431820478
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/402	57/9376	0.818364318757092	FADS1/TECR	-0.291111640220162
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/402	86/9376	0.813606386671295	TCF7L2/DSP/EMD	-0.367517503867525
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/402	140/9376	0.832977967306325	SPP1/TGFBR1/MAP1LC3A/MEF2A/MYLK3	-0.421406715977009
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/402	59/9376	0.790623155409394	IRS2/PNPLA2	-0.341446166154993
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/402	30/9376	0.777446102819237	FOLR2	-0.258397659047646
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/402	116/9376	0.804254589123349	GAPDH/TPI1/H6PD/PGD	-0.44897351483257
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/402	89/9376	0.786181452289116	EGFR/TUBA4A/TUBB4B	-0.4289515960708
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/402	31/9376	0.752367196276681	SMOX	-0.292283972298274
NA	NA	hsa04981	Folate transport and metabolism	1/402	31/9376	0.752367196276681	FOLR2	-0.292283972298274
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/402	90/9376	0.777446102819237	EGFR/CD3E/CD3D	-0.449001457629828
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/402	62/9376	0.752367196276681	NCOR2/RBPJ	-0.414039270668256
NA	NA	hsa04519	Cadherin signaling	15/402	404/9376	0.865967193734299	KDR/KRT8/KRT18/KRT7/YWHAE/KRT19/MYO1C/TCF7L2/EGFR/DSP/ACTN4/PTK2B/WNT10B/ROCK1/TAOK3	-0.582858041707209
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/402	63/9376	0.740424859827845	POLR2I/XPC	-0.437516264712142
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/402	254/9376	0.826419085673992	FLT1/KDR/PLCG2/ATP2B4/CXCR4/EGFR/VEGFA/MYLK3/PTK2B	-0.593580230567334
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/402	93/9376	0.752367196276681	EGFR/ATF4/PTK2B	-0.507938469463221
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/402	149/9376	0.782663861898561	PLCG2/PIP5K1C/FCER1G/EGFR/PTK2B	-0.565979174974089
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/402	122/9376	0.764701084740233	EEF2/IRS2/CREB3L1/ULK1	-0.553656910504132
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/402	122/9376	0.764701084740233	PTPRC/CD3E/CD3D/PAK4	-0.553656910504132
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/402	122/9376	0.764701084740233	PLCG2/IRS2/CREB3L1/ATF4	-0.553656910504132
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/402	34/9376	0.685981855428739	POLR2I	-0.388221785230865
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/402	34/9376	0.685981855428739	FBXW11	-0.388221785230865
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/402	66/9376	0.706769184381125	CYP11A1/CYP3A5	-0.505955554183567
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/402	35/9376	0.66638237384506	TPI1	-0.418496621305898
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/402	67/9376	0.696220390584391	GAPDH/TPI1	-0.528141309252561
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/402	36/9376	0.647871752349364	DCXR	-0.4480064946231
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/402	36/9376	0.647871752349364	RNASEH2C	-0.4480064946231
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/402	68/9376	0.685981855428739	DHRS3/CYP3A5	-0.550030337796543
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/402	154/9376	0.757252697551205	TPM1/ATP2B4/CREB3L1/ATF4/TPM3	-0.642847332433522
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/402	98/9376	0.713981114833993	PLCG2/PIP5K1C/MTMR3	-0.602401709218099
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/402	156/9376	0.747544329633882	YWHAE/CLDN5/EGFR/CDKN1A/CFLAR	-0.672957442549552
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/402	38/9376	0.613773239067819	QPRT	-0.504908704159363
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/402	158/9376	0.73808174318282	YWHAE/TGFB1/CDKN1A/ATRX/ANAPC11	-0.702718837064015
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/402	101/9376	0.692773754987439	CREB3L1/TCF7L2/WNT10B	-0.657003484255643
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/402	187/9376	0.748343842285897	CCL5/MAP1LC3A/YWHAE/CYBA/CYBB/GABARAPL1	-0.735698500998894
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/402	103/9376	0.679321837414867	UPF2/SRRM1/PABPC4	-0.692601616959575
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/402	73/9376	0.638996796837729	EGFR/CDKN1A	-0.655339894845939
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/402	217/9376	0.752367196276681	GSTA1/CREB3L1/EGFR/ATF4/VEGFA/KPNA6/KPNB1	-0.781123393291125
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/402	105/9376	0.66638237384506	PLCG2/FCER1G/LSP1	-0.727588756030659
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/402	41/9376	0.568863002062856	MAOA	-0.585538819367198
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/402	75/9376	0.62195688225539	GAPDH/TPI1	-0.695685221680096
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/402	75/9376	0.62195688225539	CD82/CDKN1A	-0.695685221680096
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/402	76/9376	0.613773239067819	EZR/MYLK3	-0.715506059285617
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/402	107/9376	0.653926628539545	CREB3L1/ATF4/SLC2A1	-0.761989985776695
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/402	43/9376	0.542404257780863	APOA1	-0.636518750903308
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/402	138/9376	0.676040089408032	CPEB4/YWHAE/FBXW11/ANAPC11	-0.81142328602748
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/402	168/9376	0.694148306088605	PRLR/EGFR/CDKN1A/IL7R/IL2RG	-0.846619968922888
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/402	78/9376	0.598035463707105	PABPC4/DHX36	-0.754476819870064
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/402	78/9376	0.598035463707105	FN1/WASF2	-0.754476819870064
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/402	44/9376	0.530076888285844	MAN1A2	-0.661258717250568
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/402	226/9376	0.722405670761238	FXYD1/MYL9/ATP2B4/CREB3L1/PDE10A/ROCK1/PPP1R12A	-0.894046062210811
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/402	47/9376	0.496242193288875	IRS2	-0.732755022709619
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/402	83/9376	0.562009230953666	CBX3/MBD5	-0.848265232869315
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/402	83/9376	0.562009230953666	CCL5/CCL4	-0.848265232869315
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/402	148/9376	0.630361704988571	TCF7L2/EGFR/CDKN1A/WNT10B	-0.959311510053846
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/402	85/9376	0.548785484342991	NME4/GUK1	-0.884437050320931
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/402	51/9376	0.457321236952492	PLCG2	-0.822449283089455
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/402	52/9376	0.448526597780329	CYP11A1	-0.843977254961258
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/402	91/9376	0.512601826034662	PLCG2/LYN	-0.988824622243205
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/402	125/9376	0.559761194029851	CTSD/FCER1G/ROCK1	-1.04870809432675
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/402	158/9376	0.590465394546256	ULK1/TTI1/WNT10B/LAMTOR4	-1.09876907848697
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/402	93/9376	0.501578130851121	FN1/CDKN1A	-1.02235098725185
NA	NA	hsa04081	Hormone signaling	6/402	219/9376	0.638996796837729	TRH/NPR3/PRLR/IRS2/RAMP1/DIO2	-1.144095132354
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/402	56/9376	0.416488983653163	FBXW11	-0.926916790414458
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/402	128/9376	0.546641791044776	NME4/GUK1/PDE10A	-1.0930202054284
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/402	59/9376	0.395311577704697	NME4	-0.986109729157251
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/402	60/9376	0.388723051409619	LYN	-1.00532049440458
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/402	133/9376	0.526091347772416	MAOA/CREB3L1/ATF4	-1.164983069461
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/402	99/9376	0.471179456254083	EGFR/CDKN1A	-1.11950946450793
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/402	62/9376	0.376183598138341	IRS2	-1.04301402792451
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/402	136/9376	0.514486391571554	IL2RG/CD3E/CD3D	-1.20709237883069
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/402	63/9376	0.370212429913922	EHMT2	-1.06151268971078
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/402	104/9376	0.448526597780329	PLD3/CEPT1	-1.19690632336324
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/402	65/9376	0.358821278224263	PNPLA2	-1.09785061252394
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/402	65/9376	0.358821278224263	SPP1	-1.09785061252394
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/402	67/9376	0.348110195292196	ATF4	-1.13335432753073
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/402	144/9376	0.485903814262023	BMP4/INHBB/WNT10B	-1.31578024598651
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/402	243/9376	0.575886002088324	RBM25/HNRNPM/SYF2/SNRPD2/PRPF6/U2SURP	-1.41770100338563
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/402	110/9376	0.424061510628675	CPEB4/ANAPC11	-1.28597323511908
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/402	71/9376	0.328498353303903	PRLR	-1.20205323003417
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/402	72/9376	0.323935876174682	PIN1	-1.21877887963691
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/402	115/9376	0.405624053644819	CREB3L1/ATF4	-1.35733433773167
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/402	154/9376	0.454351618530723	DHRS3/NME4/QPRT	-1.44499486888504
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/402	191/9376	0.488447813289573	FOSB/MAOA/CREB3L1/ATF4	-1.51172460205428
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/402	83/9376	0.281004615476833	PRDX5	-1.39249233177329
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/402	168/9376	0.416488983653163	TNFSF10/CYBB/CFLAR	-1.61520138145397
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/402	89/9376	0.262060484096372	GABARAPL1	-1.48041569143284
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/402	90/9376	0.259148700939746	SLC2A1	-1.49466406735096
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/402	91/9376	0.256300913017331	PDE10A	-1.50880329067575
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/402	94/9376	0.248121096644437	FOSB	-1.55058891964
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/402	99/9376	0.235589728127042	PLCG2	-1.61825130330041
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/402	102/9376	0.228660618476246	ATP2B4	-1.65774481232479
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/402	115/9376	0.20281202682241	MAOA	-1.82048182847234
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/402	183/9376	0.254900361580078	FBL/FCF1	-2.15435316759008
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/402	138/9376	0.169010022352008	IRS2	-2.08138290039321
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/402	370/9376	0.378217022993142	NPW/TRH/PRLR/RXFP1/LYNX1/C5AR1	-2.58273204326193