category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	36/276	238/9376	5.13847278041651	RPL13A/C1QB/C1QA/RPS26/RPS11/RPS20/RPS8/RPL8/CFD/RPL28/RPLP0/RPL23/RPS28/C1QC/RPL18A/RPL7/RPL37A/RPS16/RPL10/RPS9/RPS2/EGFR/CCL2/RPS14/UBA52/C1R/RPS15/RPL13/RPS5/RPLP2/C1S/FCGR2A/RPL27A/NFKBIB/C5AR1/CYBB	11.2621806115742
Genetic Information Processing	Translation	hsa03010	Ribosome	26/276	222/9376	3.97858728293511	RPL13A/RPS26/RPS11/RPS20/RPS8/RPL8/RPL28/RPLP0/RPL23/RPS28/RPL18A/RPL7/RPL37A/RPS16/RPL10/RPS9/RPS2/RPS14/UBA52/RPS15/RPL13/RPS5/RPLP2/MRPL21/MRPS34/RPL27A	7.82169446304036
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/276	88/9376	6.17654808959157	SERPINE2/C1QB/C1QA/SERPINE1/CFD/SERPING1/CD59/C1QC/CLU/TFPI/C1R/A2M/C1S/F2R/VSIG4/C5AR1	8.49649817959496
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	28/276	275/9376	3.45886693017128	MT-CO2/MT-CYB/MT-CO3/MT-ND3/C1QB/C1QA/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/C1QC/MT-ND5/COX7A1/CAV1/NDUFC1/PSMD14/ATP5MC1/PSMC1/NDUFA11/PSMC5/LAMC1/TUBB4B/NDUFB4/EGR1/NDUFA1/PSMD4/CYBB	7.2073613894671
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	26/276	268/9376	3.29569543586416	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/MT-ND5/COX7A1/NDUFC1/UBA52/UBE2G2/PSMD14/MAOA/TXN2/BCL2L1/ATP5MC1/PSMC1/NDUFA11/PSMC5/TUBB4B/NDUFB4/NDUFA1/PSMD4	6.64032965081189
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/276	308/9376	3.08827404479578	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/TGM2/MT-ND2/MT-CO1/MT-ATP6/MT-ND5/COX7A1/NDUFC1/PSMD14/CREBBP/GPX3/DCTN5/DCTN2/ATP5MC1/PSMC1/NDUFA11/PSMC5/TUBB4B/AP2A1/NDUFB4/CLTC/NDUFA1/PSMD4	6.48972921622872
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/276	138/9376	4.18483511867255	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/MT-ND5/COX7A1/NDUFC1/ATP5MC1/NDUFA11/ATP6V1F/NDUFB4/NDUFA1	6.56382510774869
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/276	205/9376	3.47995758218452	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/GAPDH/MT-ND5/COX7A1/MMP2/NDUFC1/CTSD/ATP5MC1/NDUFA11/INSR/NDUFB4/NDUFA1/CYBB	6.25219218836276
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	28/276	368/9376	2.58475110270951	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/ACTB/MT-ND5/COX7A1/NDUFC1/PSMD14/RAB1A/GPX3/DCTN5/DCTN2/BCL2L1/ATP5MC1/PSMC1/NDUFA11/PSMC5/VCP/TUBB4B/NDUFB4/NDUFA1/PSMD4	5.40120009086341
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/276	99/9376	4.46084028692724	C1QB/C1QA/HLA-DRA/KRT18/KRT19/CFD/C1QC/HLA-DRB5/C1R/C1S/ITGAL/FCGR2A/C5AR1	6.02857765824333
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	32/276	480/9376	2.26473429951691	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/DKK1/MT-ND5/COX7A1/NDUFC1/UBA52/UBE2G2/PSMD14/WNT5A/RAB1A/GPX3/DCTN5/DCTN2/BCL2L1/ATP5MC1/PSMC1/NDUFA11/PSMC5/VCP/TUBB4B/NDUFB4/NDUFA1/PSMD4/CYBB	4.95384040883871
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/276	110/9376	4.01475625823452	FLT1/TIMP1/SERPINE1/GAPDH/EGFR/ELOB/CREBBP/ELOC/ALDOA/INSR/VEGFA/EGLN3/CYBB	5.5388790669682
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/276	388/9376	2.36396234872255	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/APOE/MT-ND2/MT-CO1/MT-ATP6/GAPDH/DKK1/MT-ND5/COX7A1/NDUFC1/PSMD14/WNT5A/ATP5MC1/PSMC1/NDUFA11/PSMC5/INSR/TUBB4B/NDUFB4/NDUFA1/PSMD4/CYBB	4.77866070807642
NA	NA	hsa04518	Integrin signaling	15/276	154/9376	3.30886504799548	FN1/FLT1/ACTB/SPP1/FERMT2/EGFR/FBN1/ITGB8/COL6A3/ITGAL/LAMA4/LAMC1/VEGFA/TLN1/COL6A2	5.03113341343212
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	20/276	250/9376	2.71768115942029	PSAP/CTSL/CTSB/CD63/CD68/HEXB/NPC2/CTSZ/CTSK/VPS41/CTSD/CTSH/LAMTOR5/LAMTOR2/LAMP2/ATP6V1F/BLOC1S1/AP2A1/MCOLN2/CLTC	4.79393131354031
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/276	233/9376	2.77016856378678	FN1/DCN/MYL9/FBLN1/ACTB/TPM1/VCAN/FBN1/PDLIM1/TPM2/ITGB8/COL6A3/NID1/BGN/PDLIM4/DSP/TLN1/COL6A2/FHL2	4.76505269380089
NA	NA	hsa03272	Virion - Hepatitis viruses	8/276	48/9376	5.66183574879227	CD63/CD81/EGFR/VPS4B/LDLR/CHMP4B/LAMP2/CLDN5	5.63900917146196
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	18/276	227/9376	2.69373683202452	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/MT-ND5/COX7A1/EGFR/NDUFC1/ATP5MC1/NDUFA11/VEGFA/NDUFB4/NDUFA1	4.49874658176298
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/276	155/9376	3.06834969611968	HLA-DRA/ACTB/CTSL/CD14/HLA-G/HLA-DRB5/C1R/HGS/FCGR2A/DYNC1LI1/LAMP2/TUBB4B/ATP6V1F/CYBB	4.52189306688138
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	18/276	235/9376	2.60203515263645	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-CO1/MT-ATP6/ACTB/MT-ND5/COX7A1/NDUFC1/MGLL/ATP5MC1/NDUFA11/NDUFB4/NDUFA1	4.33140308072684
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/276	42/9376	5.66183574879227	FTL/FTH1/SLC40A1/SAT1/GPX4/NCOA4/CYBB	5.27311445401406
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/276	52/9376	4.57302118171683	APOE/NPC2/PLTP/APOC1/LRPAP1/LDLR/APOA1	4.49941045653232
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/276	250/9376	2.31002898550725	RAB31/CAV1/HLA-G/EGFR/VPS4B/FOLR2/DAB2/RABEP1/HGS/RAB11B/LDLR/CHMP4B/SNF8/EHD2/AP2A1/CLTC/WASHC2A	3.6562018165165
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/276	95/9376	3.21830663615561	FLT1/HLA-DRA/CTSL/CCL2/HLA-DRB5/CTSK/ITGAL/ATP6V1F/VEGFA	3.78447358078755
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/276	203/9376	2.34282858570715	FN1/FLT1/MYL9/ACTB/SPP1/CAV1/EGFR/ITGB8/COL6A3/LAMA4/LAMC1/VEGFA/TLN1/COL6A2	3.36846766728676
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/276	70/9376	3.39710144927536	HLA-DRA/ACTB/CAV1/HLA-G/HLA-DRB5/EIF4G1/ITGAL	3.50568906083289
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/276	149/9376	2.50792724443148	MT-ND3/MT-ND4/MT-ND1/MT-ND2/MT-ND5/NDUFC1/MGLL/NDUFA11/NDUFB4/GNG11/NDUFA1	3.2311918508122
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/276	78/9376	3.04868078781122	C1QB/C1QA/SERPING1/C1QC/CD14/C1R/C1S	3.16407164073916
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/276	142/9376	2.39232496427842	ACTB/CTSL/IL1R1/CAV1/MMP2/IL1R2/CCL2/GSTP1/TXN2/VEGFA	2.91144996051935
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/276	333/9376	1.83627105366236	FN1/SPP1/HLA-G/EGFR/ITGB8/NFX1/WNT5A/COL6A3/CREBBP/TCF7L2/PSMC1/LAMA4/LAMC1/BCAP31/ATP6V1F/VEGFA/COL6A2/CDK4	2.70602870355484
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/276	101/9376	2.6907734251686	FN1/SERPINE1/MMP2/CCL2/VEGFA/EGR1/CDK4/CYBB	2.97514833715473
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/276	362/9376	1.78300904796221	FN1/FLT1/PRL/SPP1/PRLR/EGFR/ITGB8/CSH1/COL6A3/F2R/BCL2L1/LAMA4/INSR/LAMC1/VEGFA/COL6A2/PKN1/GNG11/CDK4	2.64595084589827
NA	NA	hsa04382	Cornified envelope formation	13/276	217/9376	2.03512990048754	S100A6/KRT8/KRT18/KRT19/KRT7/S100A9/S100A11/S100A13/DST/COL17A1/DSP/CLDN5/S100A4	2.68670617923475
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/276	87/9376	2.73330001665834	MT-CO2/MT-CYB/MT-CO3/MT-CO1/TPM1/COX7A1/TPM2	2.82857936722188
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/276	248/9376	1.9177185600748	MYL9/ACTB/GAPDH/CD14/ANXA2/DCTN5/DCTN2/TXN2/VPS41/TCF7L2/DYNC1LI1/TUBB4B/AHNAK2/PKN1	2.55074487544056
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/276	89/9376	2.67187754437388	FN1/SPP1/ITGB8/COL6A3/LAMA4/LAMC1/COL6A2	2.75982299098976
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/276	204/9376	1.99829497016198	TIMP3/FN1/LUM/DCN/ACTB/CTSL/CD63/CAV1/EGFR/MMP2/WNT5A/VEGFA	2.51050694257201
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/276	157/9376	2.16375888488877	MT-CO2/MT-CYB/MT-CO3/MT-CO1/COX7A1/NDUFC1/NDUFA11/INSR/NDUFB4/NDUFA1	2.56088697626403
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/276	75/9376	2.71768115942029	IGFBP3/SERPINE1/BCL2L1/SHISA5/CD82/CDK4	2.60092509309517
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/276	41/9376	3.31424531636621	EGFR/MMP2/VEGFA/CDK4	2.58620914908548
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/276	103/9376	2.3087097228085	FN1/HSPB1/CD14/IL1R1/IL1R2/LAMA4/LAMC1	2.3257942605813
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/276	82/9376	2.48568398727466	HLA-DRA/CD74/CTSL/CTSB/HLA-G/HLA-DRB5	2.35316032663072
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/276	44/9376	3.08827404479578	DCTN5/DCTN2/RAB11B/DYNC1LI1	2.41794237765994
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/276	205/9376	1.82283492400141	HLA-DRA/HLA-G/HLA-DRB5/PSMD14/POLK/ITGAL/PSMC1/PSMC5/NFKBIB/PSMD4/CDK4	2.0744395473176
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/276	46/9376	2.95400126023945	PSMD14/PSMC1/PSMC5/PSMD4	2.31356878729643
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/276	112/9376	2.1231884057971	HLA-DRA/HLA-DRB5/BCL2L1/LAMA4/LDLR/NFKBIB/LAMC1	2.08248476546398
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/276	137/9376	1.98370887548926	ACTB/CTSL/CTSB/CTSZ/CTSK/BCL2L1/CTSD/CTSH	2.01991862138175
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/276	70/9376	2.42650103519669	ELOB/CREBBP/ELOC/VEGFA/EGLN3	2.08621503101906
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/276	116/9376	2.04997501249375	MYL9/ACTB/THY1/MMP2/ITGAL/CLDN5/CYBB	1.98162716956051
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/276	93/9376	2.1916783543712	MYL9/ACTB/EGFR/CREBBP/TCF7L2/INSR	2.01129527348825
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/276	93/9376	2.1916783543712	FN1/POLK/BCL2L1/LAMA4/LAMC1/CDK4	2.01129527348825
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/276	50/9376	2.71768115942029	CD81/CCL2/HBB/ITGAL	2.12079812981741
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/276	143/9376	1.90047633525894	C1QB/C1QA/HLA-DRA/C1QC/HLA-DRB5/C1R/C1S/FCGR2A	1.88968052803963
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/276	73/9376	2.32678181457217	MAP1B/VPS4B/CREBBP/HGS/CHMP4B	1.98184147522351
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	11/276	224/9376	1.66821946169772	HLA-DRA/IL1R1/HLA-G/IL1R2/HLA-DRB5/CREBBP/ITGAL/BCL2L1/TLN1/EGR1/CDK4	1.76280635178815
Human Diseases	Immune disease	hsa05310	Asthma	3/276	32/9376	3.18478260869565	HLA-DRA/PRG2/HLA-DRB5	2.15593809965904
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/276	100/9376	2.03826086956522	HLA-DRA/CD59/CD14/IL1R1/IL1R2/HLA-DRB5	1.81779790903033
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/276	77/9376	2.20591003199699	EGFR/POLK/BCL2L1/VEGFA/CDK4	1.85038300039063
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/276	78/9376	2.17762913415087	HLA-DRA/HLA-DRB5/FCGR2A/NFKBIB/CYBB	1.81878161246189
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/276	56/9376	2.42650103519669	CD14/RAB1A/VCP/HSF1	1.864565445616
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/276	106/9376	1.92288761279737	EGFR/IL1R2/FOLR2/CREBBP/GSTP1/TCF7L2	1.66410745220858
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/276	37/9376	2.75440658049354	HBB/LAMA4/APOA1	1.86208887333941
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/276	37/9376	2.75440658049354	POLK/TCF7L2/NCOA4	1.86208887333941
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/276	160/9376	1.69855072463768	HLA-DRA/VCAN/HLA-G/HLA-DRB5/ITGB8/ITGAL/GLG1/CLDN5	1.55205171796021
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/276	39/9376	2.61315496098105	HLA-DRA/HLA-G/HLA-DRB5	1.75802155348984
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/276	86/9376	1.97505898213684	ACTB/GJA1/ITGB8/TCF7L2/DSP	1.58194630717952
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/276	63/9376	2.15688980906372	HPGD/PTGDS/PTGES/GPX4	1.60448976745541
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/276	194/9376	1.57597489914836	MYL9/ACTB/TPM1/MYL6/TPM2/DCTN5/DCTN2/DYNC1LI1/TUBB4B	1.41174175890303
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/276	42/9376	2.42650103519669	AOC1/MAOA/ECHS1	1.61354960421126
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/276	169/9376	1.60809536060372	CTSL/CTSB/UBA52/RAB1A/BCL2L1/VPS41/CTSD/LAMP2	1.38923416048528
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/276	170/9376	1.59863597612958	ACTB/EGFR/WNT5A/POLK/GSTP1/BCL2L1/TCF7L2/CDK4	1.37173832163669
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/276	22/9376	3.08827404479578	AOC1/MAOA	1.70773166543413
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/276	200/9376	1.52869565217391	ACTB/GAPDH/IL1R1/RAB1A/F2R/FCGR2A/NFKBIB/TUBB4B/CLDN5	1.31617463636466
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/276	173/9376	1.57091396498283	HLA-DRA/ACTB/CCL2/HLA-DRB5/CREBBP/RAB11B/NFKBIB/CDK4	1.31992267573056
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/276	44/9376	2.31620553359684	HLA-DRA/HLA-G/HLA-DRB5	1.52399017998882
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/276	45/9376	2.26473429951691	HLA-DRA/HLA-G/HLA-DRB5	1.48102006356625
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/276	181/9376	1.50148130354712	HLA-DRA/CD74/CD14/HLA-DRB5/CREBBP/CTSD/FCGR2A/LAMP2	1.18641778896733
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/276	298/9376	1.36796031514444	PRL/IL1RL1/PRLR/CXCL14/EBI3/IL1R1/IL1R2/CCL2/CSH1/CCL21/CCL18/TNFRSF11B	1.12417392591604
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/276	50/9376	2.03826086956522	AOC1/SAT1/MAOA	1.28192691545831
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/276	103/9376	1.64907837343464	C1QB/C1QA/SERPINE1/C1QC/CCL2	1.15351993592749
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/276	52/9376	1.95986622073579	LDLR/CYP11A1/INSR	1.20873397911835
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/276	78/9376	1.7421033073207	FN1/ACTB/CAV1/CLTC	1.14613659832325
NA	NA	hsa04081	Hormone signaling	9/276	219/9376	1.3960690887433	PRL/RAMP1/PRLR/SLC40A1/ADRA2C/CSH1/DIO2/INSR/GNG11	1.03284673877712
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/276	80/9376	1.69855072463768	EGFR/AXL/BCL2L1/VEGFA	1.09273377443795
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/276	54/9376	1.88727858293076	HLA-DRA/HLA-G/HLA-DRB5	1.13873275315673
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	10/276	253/9376	1.34272784556338	MYL9/ACTB/CD14/IL1R1/EGFR/UBA52/FBXW11/BCL2L1/NFKBIB/TLN1	0.962410377233414
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/276	109/9376	1.55830341709879	HLA-DRA/EBI3/IL1R1/HLA-DRB5/NFKBIB	1.0210180892396
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/276	55/9376	1.85296442687747	PSAP/HEXB/PLPP3	1.10484280806708
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/276	110/9376	1.54413702239789	DCN/FBN1/EMP3/LTBP1/CREBBP	0.999719016981849
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/276	142/9376	1.43539497856705	ELOB/UBA52/UBE2G2/FBXW11/ELOC/DDB1	0.910441689750442
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/276	201/9376	1.35208017881606	IGFBP3/FLT1/NUPR1/HPGD/CD14/IL1R2/POLK/BCL2L1	0.87873120976324
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/276	144/9376	1.41545893719807	C1QB/C1QA/C1QC/CD14/TCF7L2/C5AR1	0.874945369376117
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/276	59/9376	1.72733971997052	GSTP1/GPX3/GPX4	0.975988602749163
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/276	59/9376	1.72733971997052	EGFR/POLK/TCF7L2	0.975988602749163
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/276	34/9376	1.99829497016198	RORB/FBXW11	1.01554200876126
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/276	61/9376	1.67070563079116	FTL/FTH1/SLC40A1	0.915218780493653
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/276	178/9376	1.33593877218694	NOTUM/DKK1/WNT5A/FBXW11/CREBBP/TCF7L2/APCDD1	0.788030292080476
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/276	63/9376	1.61766735679779	WNT5A/POLK/TCF7L2	0.856642478746825
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/276	212/9376	1.28192507519825	FLT1/ACTB/EGFR/ITGAL/F2R/INSR/VEGFA/TLN1	0.723067061552023
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/276	93/9376	1.46111890291413	EGFR/MMP2/MMP14/EGR1	0.778268957009512
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/276	155/9376	1.31500701262272	EGFR/WNT5A/TCF7L2/LDLR/CYP11A1/CDK4	0.688678529104623
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/276	38/9376	1.78794813119756	HEXB/NAGK	0.847582490516924
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/276	187/9376	1.27164225373944	CTSB/CCL2/TXN2/BCL2L1/NFKBIB/PKN1/CYBB	0.653436644048593
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/276	157/9376	1.29825533093326	C1QB/C1QA/C1QC/MFGE8/AXL/VPS41	0.656319966709691
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/276	98/9376	1.38657202011239	MARCKS/GSN/PLPP3/FCGR2A	0.669939760474492
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/276	99/9376	1.37256624213146	ACTB/TPM1/TPM2/ITGB8	0.648988204400376
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/276	100/9376	1.35884057971015	CXCL14/CCL2/CCL21/CCL18	0.628261812222097
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/276	196/9376	1.21325051759834	HLA-G/UBA52/CREBBP/TCF7L2/VEGFA/GNG11/CDK4	0.525431701564931
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/276	134/9376	1.26757516764006	CALD1/MYL9/RAMP1/MYL6/ADM	0.543293746715294
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/276	103/9376	1.31926269874771	COL6A3/COL17A1/COL6A2/SLC7A8	0.567382773600578
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/276	15/9376	2.26473429951691	HEXB	0.853696079022059
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/276	43/9376	1.58004718570947	PLPP3/APOA1	0.66390570708623
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/276	73/9376	1.3960690887433	EGFR/POLK/CDK4	0.591616600788702
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/276	73/9376	1.3960690887433	EGFR/POLK/CDK4	0.591616600788702
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/276	44/9376	1.54413702239789	HEXB/MAN1A2	0.6300379823177
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/276	105/9376	1.29413388543823	CD14/IL1R1/CCL21/BCL2L1	0.527832226106992
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/276	105/9376	1.29413388543823	ACTB/TPM1/TPM2/ITGB8	0.527832226106992
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/276	168/9376	1.21325051759834	PRL/PRLR/EGFR/CSH1/CREBBP/BCL2L1	0.485715052432591
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/276	232/9376	1.17141429285357	FN1/MYL9/ACTB/EGFR/GSN/ITGB8/ITGAL/F2R	0.460407509110586
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/276	16/9376	2.1231884057971	MAOA	0.783058416455517
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/276	16/9376	2.1231884057971	HEXB	0.783058416455517
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/276	138/9376	1.2308338584331	FN1/ACTB/CCL2/FCGR2A/PKN1	0.475739879536755
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/276	76/9376	1.34096109839817	EGFR/POLK/CDK4	0.519744181790871
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/276	139/9376	1.22197893858826	KRT18/KRT19/EGFR/MMP2/CTSD	0.459169657726258
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/276	46/9376	1.47700063011972	FTL/FTH1	0.564776385676684
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/276	77/9376	1.32354601919819	POLK/BCL2L1/CDK4	0.496458307737084
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/276	17/9376	1.99829497016198	LAMP2	0.717444157187653
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/276	174/9376	1.17141429285357	CRYAB/UBE2G2/SSR4/VCP/BCAP31/MAN1A2	0.397466036564652
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/276	142/9376	1.19616248213921	IL1R1/CTSK/FCGR2A/TNFRSF11B/FHL2	0.410189622058216
NA	NA	hsa04519	Cadherin signaling	13/276	404/9376	1.09312670397475	KRT8/KRT18/KRT19/ACTB/KRT7/EGFR/GJA1/WNT5A/CREBBP/CDH11/TCF7L2/LHFPL6/DSP	0.333226679439426
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/276	79/9376	1.29003852504128	ATP6V1F/AP2A1/CLTC	0.450834664242993
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/276	18/9376	1.88727858293076	HEXB	0.656181850372538
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/276	19/9376	1.78794813119756	HEXB	0.598722526737261
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/276	50/9376	1.35884057971015	HLA-DRA/HLA-DRB5	0.443055701099215
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/276	180/9376	1.13236714975845	HLA-DRA/CD74/HLA-G/CCL2/HLA-DRB5/BCL2L1	0.312274464070295
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/276	148/9376	1.14766940853897	EGFR/WNT5A/POLK/TCF7L2/CDK4	0.315345823324018
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/276	214/9376	1.11120140864147	HLA-G/ELOB/FBXW11/ELOC/BCL2L1/DDB1/GNG11	0.286577120573239
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/276	51/9376	1.33219664677465	ACTB/ATP6V1F	0.414262283919776
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/276	53/9376	1.28192507519825	AP2A1/CLTC	0.358437368876113
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/276	21/9376	1.61766735679779	CHPF	0.493471282884095
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/276	87/9376	1.17141429285357	EGFR/POLK/TCF7L2	0.279731683697388
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/276	54/9376	1.25818572195384	POLK/CENPX	0.331355386732238
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/276	156/9376	1.08881456707544	CD81/EGFR/LDLR/CLDN5/CDK4	0.194805190778754
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/276	89/9376	1.14509037616023	EGFR/GJA1/TUBB4B	0.239505433424747
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/276	157/9376	1.08187944244438	IGFBP3/SERPINE1/HLA-G/FBXW11/CDK4	0.180178214321107
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/276	157/9376	1.08187944244438	SERPINE1/ACTB/WNT5A/FBXW11/TCF7L2	0.180178214321107
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/276	56/9376	1.21325051759834	FBXW11/GAS1	0.278737650070316
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/276	158/9376	1.07503210420106	WNT5A/LAMTOR5/INSR/LAMTOR2/ATP6V1F	0.16564441621705
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/276	193/9376	1.05609371480063	CXCL14/CCL2/CCL21/CCL18/NFKBIB/GNG11	0.137126075707131
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/276	227/9376	1.04756432356509	IL1R1/HLA-G/EGFR/CCL2/VEGFA/GNG11/CDK4	0.126335941928208
Organismal Systems	Immune system	hsa04611	Platelet activation	4/276	126/9376	1.07844490453186	ACTB/F2R/FCGR2A/TLN1	0.154382698586459
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/276	93/9376	1.0958391771856	HLA-DRA/HLA-DRB5/NFKBIB	0.161755798770142
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/276	59/9376	1.15155981331368	MGLL/INSR	0.203372160721457
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/276	94/9376	1.08418131359852	S100A9/CCL2/MAPK6	0.142849368953355
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/276	60/9376	1.13236714975845	HSPB1/VEGFA	0.179126807487271
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/276	130/9376	1.04526198439242	EGFR/MMP2/VEGFA/GNG11	0.0904998387114296
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/276	26/9376	1.30657748049052	APOA1	0.272609259076832
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/276	62/9376	1.0958391771856	CRYAB/INSR	0.131853082559245
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/276	133/9376	1.02168464639861	EGFR/DEPP1/CREBBP/INSR	0.0438622768493173
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/276	168/9376	1.01104209799862	FTL/FTH1/VPS4B/CHMP4B/CYBB	0.025150293977092
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/276	27/9376	1.25818572195384	ECHS1	0.233965060748366
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/276	99/9376	1.02942468159859	EGFR/MMP2/CDK4	0.0512560428622693
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/276	205/9376	0.994273594909862	HLA-G/GSN/CREBBP/DDB1/PSMC1/CDK4	-0.0144367732049768
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/276	170/9376	0.999147485080989	MYL9/ACTB/MYL6/CLDN5/CDK4	-0.00195348664431309
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/276	28/9376	1.21325051759834	ECHS1	0.196801879099589
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/276	28/9376	1.21325051759834	ATP6V1F	0.196801879099589
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/276	65/9376	1.04526198439242	PLPP3/MGLL	0.0637692910239275
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/276	65/9376	1.04526198439242	LDLR/CYP11A1	0.0637692910239275
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/276	101/9376	1.00904003443823	WNT5A/CREBBP/TCF7L2	0.0159071836748493
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/276	66/9376	1.02942468159859	HSD11B1/CYP11A1	0.0417761469789068
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/276	66/9376	1.02942468159859	HLA-DRA/HLA-DRB5	0.0417761469789068
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/276	67/9376	1.01406013411205	GAPDH/ALDOA	0.0201138326528177
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/276	30/9376	1.13236714975845	FOLR2	0.126458329184418
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/276	140/9376	0.970600414078675	SERPINE1/SPP1/GNG11/EGR1	-0.0610355345412485
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/276	68/9376	0.999147485080989	CD14/TCF7L2	-0.0012287053237717
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/276	105/9376	0.970600414078675	UBA52/BCL2L1/VCP	-0.0527584533837584
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/276	31/9376	1.0958391771856	ALDOA	0.0930794382571189
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/276	31/9376	1.0958391771856	ECHS1	0.0930794382571189
NA	NA	hsa04981	Folate transport and metabolism	1/276	31/9376	1.0958391771856	FOLR2	0.0930794382571189
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/276	70/9376	0.970600414078675	HSD11B1/GSTP1	-0.0429960137016989
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/276	216/9376	0.943639291465379	CD14/CCL2/BCL2L1/LDLR/APOA1/CYBB	-0.145940243316333
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/276	32/9376	1.06159420289855	ECHS1	0.060781007784749
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/276	32/9376	1.06159420289855	BCL2L1	0.060781007784749
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/276	144/9376	0.943639291465379	PSMD14/PSMC1/PSMC5/PSMD4	-0.11869413925645
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/276	71/9376	0.95692998571137	PRL/PRLR	-0.0634403374700364
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/276	71/9376	0.95692998571137	EGFR/ATP6V1F	-0.0634403374700364
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/276	109/9376	0.934982050259274	SPP1/CD14/CTSK	-0.118903988006231
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/276	73/9376	0.930712725828866	MAOA/GSTP1	-0.1034958364287
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/276	149/9376	0.911973543429627	EGFR/PLPP3/F2R/INSR	-0.188623403533835
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/276	150/9376	0.905893719806763	EGFR/WNT5A/POLK/TCF7L2	-0.202337786446515
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/276	35/9376	0.970600414078675	ALDOA	-0.0303457609857529
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/276	75/9376	0.905893719806763	GAPDH/ALDOA	-0.142496402332922
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/276	75/9376	0.905893719806763	GSTP1/BCL2L1	-0.142496402332922
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/276	36/9376	0.943639291465379	GALNT15	-0.0590029518600285
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/276	76/9376	0.89397406559878	PLTP/APOA1	-0.161620673979711
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/276	115/9376	0.886200378071834	EGFR/MMP14/EGR1	-0.213835733342197
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/276	116/9376	0.87856071964018	GAPDH/ALDOA/ECHS1	-0.229193432747837
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/276	154/9376	0.882364012798795	MYL9/ACTB/MYL6/EGFR	-0.256334750419424
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/276	37/9376	0.918135526831179	MAOA	-0.0868891660031115
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/276	37/9376	0.918135526831179	NAGK	-0.0868891660031115
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/276	38/9376	0.89397406559878	INSR	-0.114050306081174
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/276	79/9376	0.860025683360851	HSD11B1/GSTP1	-0.217575489448073
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/276	195/9376	0.871051653660349	ACTB/ITGAL/FCGR2A/C5AR1/CYBB	-0.316889297751732
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/276	122/9376	0.835352815395581	ACTB/DIO2/CREBBP	-0.318778453719641
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/276	122/9376	0.835352815395581	IGFBP3/CSH1/CREBBP	-0.318778453719641
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/276	41/9376	0.828561329091552	MAOA	-0.191585678525502
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/276	238/9376	0.856412130069419	FLT1/EGFR/BCL2L1/INSR/VEGFA/GNG11	-0.390751035609486
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/276	43/9376	0.790023592854735	ECHS1	-0.240333094430402
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/276	90/9376	0.754911433172303	EGFR/NFKBIB	-0.406864174182479
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/276	91/9376	0.746615703137442	CD81/NFKBIB	-0.422988852214534
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/276	47/9376	0.722787542399013	GLO1	-0.331790241504045
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/276	47/9376	0.722787542399013	INSR	-0.331790241504045
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/276	48/9376	0.707729468599034	ECHS1	-0.353533735620154
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/276	93/9376	0.730559451457067	CST3/LYZ	-0.454757359469228
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/276	370/9376	0.826321974148061	PRL/NPW/PRLR/TAC3/ADM/ADRA2C/CSH1/F2R/C5AR1	-0.593607320013727
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/276	136/9376	0.749360613810742	BCL2L1/NFKBIB/CDK4	-0.51274598687037
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/276	49/9376	0.693286010056196	GALNT15	-0.374869511552245
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/276	49/9376	0.693286010056196	MAOA	-0.374869511552245
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/276	51/9376	0.666098323387326	PLPP3	-0.416388523187115
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/276	300/9376	0.792657004830918	FLT1/HSPB1/CD14/IL1R1/EGFR/INSR/VEGFA	-0.63565612291971
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/276	98/9376	0.693286010056196	LDLR/CYP11A1	-0.531543635510366
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/276	99/9376	0.68628312106573	EGFR/PLPP3	-0.546476118675837
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/276	56/9376	0.606625258799172	MAN1A2	-0.514176247702525
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/276	57/9376	0.595982710399186	ECHS1	-0.532809801964195
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/276	108/9376	0.629092860976919	UPF2/IPO5	-0.67515508157108
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/276	62/9376	0.5479195885928	CREBBP	-0.621960638218489
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/276	63/9376	0.53922245226593	ECHS1	-0.63905209867035
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/276	63/9376	0.53922245226593	DDB1	-0.63905209867035
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/276	158/9376	0.645019262520638	CDKN1C/CREBBP/CDK4	-0.78367223809289
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/276	115/9376	0.590800252047889	MAOA/GNG11	-0.768908777588166
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/276	65/9376	0.52263099219621	SPP1	-0.672561832917383
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/276	117/9376	0.580701102440233	ACTB/BAZ2A	-0.794793107886791
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/276	67/9376	0.507030067056024	CREBBP	-0.705221917165717
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/276	68/9376	0.499573742540494	ALDH1A2	-0.721250025053933
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/276	119/9376	0.570941420046279	CCL2/MMP14	-0.820303232524395
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/276	166/9376	0.613933996856993	MYL9/ADRA2C/INSR	-0.873987600972628
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/276	254/9376	0.668720757731371	FLT1/EGFR/F2R/VEGFA/MCOLN2	-0.932149415456656
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/276	69/9376	0.492333543373241	CTSB	-0.737085114067198
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/276	69/9376	0.492333543373241	MAOA	-0.737085114067198
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/276	70/9376	0.485300207039338	NFKBIB	-0.752733028608617
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/276	122/9376	0.556901876930387	RAB11B/INSR	-0.857895838653868
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/276	122/9376	0.556901876930387	NFKBIB/CDK4	-0.857895838653868
NA	NA	hsa04517	IgSF CAM signaling	6/276	299/9376	0.681692598516795	MYL9/ACTB/MYL6/ITGAL/CLMP/TUBB4B	-0.974160793398946
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/276	71/9376	0.478464992855685	EGFR	-0.768199347089778
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/276	72/9376	0.471819645732689	NFKBIB	-0.783489397805295
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/276	75/9376	0.452946859903382	GPX3	-0.828351776189944
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/276	76/9376	0.44698703279939	ACTB	-0.842985529750294
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/276	226/9376	0.601256893677055	MYL9/FXYD1/CREBBP/F2R	-1.05671128013307
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/276	133/9376	0.510842323199303	HLA-G/ITGAL	-0.989435983801937
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/276	133/9376	0.510842323199303	MAOA/GNG11	-0.989435983801937
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/276	183/9376	0.556901876930387	NHP2/SNU13/DKC1	-1.05418372789774
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/276	184/9376	0.553875236294896	MYL9/WNT5A/SEMA3B	-1.06433836675678
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/276	82/9376	0.414280664545776	GSTP1	-0.927715122823483
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/276	83/9376	0.409289331237995	CREBBP	-0.941359208653913
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/276	83/9376	0.409289331237995	NFKBIB	-0.941359208653913
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/276	138/9376	0.492333543373241	FLOT1/INSR	-1.04628142751623
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/276	323/9376	0.631040516893256	TIMP3/TPM1/MARCKS/EGFR/CREBBP/VEGFA	-1.17517667036385
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/276	86/9376	0.395011796427368	EGFR	-0.981539447420404
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/276	89/9376	0.381696792053411	GNG11	-1.02065334535776
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/276	243/9376	0.559193654201706	HNRNPM/CTNNBL1/PRPF6/SNU13	-1.21244969607653
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/276	90/9376	0.377455716586151	INSR	-1.03346708107061
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/276	90/9376	0.377455716586151	LDLR	-1.03346708107061
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/276	91/9376	0.373307851568721	GNG11	-1.04617293115285
NA	NA	hsa04082	Neuroactive ligand signaling	3/276	199/9376	0.512125846624426	TAC3/ADRA2C/GNG11	-1.21144434241253
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/276	154/9376	0.441182006399398	TPM1/TPM2	-1.21769259839243
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/276	97/9376	0.350216644255192	GNG11	-1.12027164950355
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/276	99/9376	0.343141560532865	IL1R1	-1.14420828021394
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/276	103/9376	0.329815674686928	UPF2	-1.19102871338015
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/276	163/9376	0.416822263714768	CREBBP/DDB1	-1.30801789451598
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/276	104/9376	0.326644370122631	PLPP3	-1.20252450956214
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/276	107/9376	0.317486116754707	CREBBP	-1.23653502060014
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/276	109/9376	0.311660683419758	INSR	-1.25882606525206
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/276	115/9376	0.295400126023945	GNG11	-1.32398182183414
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/276	116/9376	0.292853573213393	GNG11	-1.33460373390201
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/276	120/9376	0.283091787439613	NFKBIB	-1.37645490776458
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/276	125/9376	0.271768115942029	CTSD	-1.42741362786807
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/276	191/9376	0.355717429243493	MAOA/GNG11	-1.56665355768781
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/276	138/9376	0.24616677168662	FBXW11	-1.55362186320056
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/276	144/9376	0.235909822866345	WNT5A	-1.6091534022053
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/276	217/9376	0.313096907767315	EGFR/VEGFA	-1.78287457600035