ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 28/425 168/18639 0.166666666666667 7.30941176470588 1.440860197721e-16 1.09073116967479e-13 GO:0003735 structural constituent of ribosome 26/425 175/18639 0.148571428571429 6.51581848739496 3.07915938813408e-14 1.16546182840875e-11 GO:0019838 growth factor binding 20/425 136/18639 0.147058823529412 6.44948096885813 3.61945638859071e-11 9.13309495387722e-09 GO:0050840 extracellular matrix binding 14/425 67/18639 0.208955223880597 9.16403863037752 2.70306687657775e-10 5.11555406392339e-08 GO:0001968 fibronectin binding 10/425 30/18639 0.333333333333333 14.6188235294118 6.83373088896807e-10 9.38722024451501e-08 GO:0005518 collagen binding 14/425 72/18639 0.194444444444444 8.52764705882353 7.44033308680186e-10 9.38722024451501e-08 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 13/425 68/18639 0.191176470588235 8.38432525951557 3.77141546158989e-09 3.91227845981477e-07 GO:0005520 insulin-like growth factor binding 8/425 19/18639 0.421052631578947 18.4658823529412 4.15066942539652e-09 3.91227845981477e-07 GO:0031994 insulin-like growth factor I binding 7/425 13/18639 0.538461538461538 23.6150226244344 4.65132181483922e-09 3.91227845981477e-07 GO:0005178 integrin binding 18/425 161/18639 0.111801242236025 4.90320789185239 3.00791673884091e-08 2.27699297130257e-06 GO:0005539 glycosaminoglycan binding 21/425 242/18639 0.0867768595041322 3.8057267865824 1.81472684521905e-07 1.2488620198462e-05 GO:0061134 peptidase regulator activity 20/425 226/18639 0.0884955752212389 3.88110359187923 2.59709490552899e-07 1.63833403623787e-05 GO:0070325 lipoprotein particle receptor binding 8/425 31/18639 0.258064516129032 11.3177988614801 3.40681457924742e-07 1.98381433576177e-05 GO:0001540 amyloid-beta binding 12/425 83/18639 0.144578313253012 6.34069454287739 3.79681309362157e-07 2.04406801350395e-05 GO:0009055 electron transfer activity 14/425 116/18639 0.120689655172414 5.29302231237323 4.05033291975684e-07 2.04406801350395e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 14/425 118/18639 0.11864406779661 5.20331006979063 5.00862642928898e-07 2.36970637935735e-05 GO:0033218 amide binding 20/425 247/18639 0.0809716599190283 3.55113122171946 1.06803330712553e-06 4.75588949114133e-05 GO:0050750 low-density lipoprotein particle receptor binding 7/425 26/18639 0.269230769230769 11.8075113122172 1.37910817446872e-06 5.79991604484903e-05 GO:0008201 heparin binding 16/425 172/18639 0.0930232558139535 4.07967168262654 2.13761517677281e-06 8.5167088885106e-05 GO:0002020 protease binding 14/425 136/18639 0.102941176470588 4.51463667820069 2.81238611196581e-06 0.000106448814337906 GO:0008137 NADH dehydrogenase (ubiquinone) activity 8/425 41/18639 0.195121951219512 8.55736011477762 3.37922871903797e-06 0.000121813149538654 GO:0015078 proton transmembrane transporter activity 16/425 185/18639 0.0864864864864865 3.7929920508744 5.51643444147692e-06 0.000189815494190819 GO:0003954 NADH dehydrogenase activity 8/425 44/18639 0.181818181818182 7.97390374331551 5.90411186579992e-06 0.000194322290539589 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/425 22/18639 0.272727272727273 11.9608556149733 7.42515489707482e-06 0.000234201760711902 GO:0043394 proteoglycan binding 7/425 37/18639 0.189189189189189 8.29717011128776 1.7381710151474e-05 0.00051279608194789 GO:0042277 peptide binding 18/425 249/18639 0.072289156626506 3.1703472714387 1.76125470682234e-05 0.00051279608194789 GO:1901681 sulfur compound binding 19/425 275/18639 0.0690909090909091 3.03008342245989 1.95245722624288e-05 0.000547411155654023 GO:0015399 primary active transmembrane transporter activity 14/425 166/18639 0.0843373493975904 3.69873848334515 2.80635760681324e-05 0.000758718824413437 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/425 58/18639 0.137931034482759 6.04916835699797 4.83261874740068e-05 0.00126148013509735 GO:0004866 endopeptidase inhibitor activity 13/425 161/18639 0.0807453416149068 3.54120569967117 8.44459480288977e-05 0.00211563561431052 GO:0061135 endopeptidase regulator activity 14/425 184/18639 0.0760869565217391 3.33690537084399 8.66376539545919e-05 0.00211563561431052 GO:0004857 enzyme inhibitor activity 23/425 416/18639 0.0552884615384615 2.42475678733032 9.15202134786621e-05 0.0021650250501046 GO:0019843 rRNA binding 8/425 65/18639 0.123076923076923 5.39771945701357 0.000110747109840905 0.00254047158028986 GO:0030414 peptidase inhibitor activity 13/425 169/18639 0.0769230769230769 3.37357466063348 0.000137935078993073 0.00307108396463989 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/425 88/18639 0.102272727272727 4.48532085561497 0.00017813243635343 0.00385275012341562 GO:0008191 metalloendopeptidase inhibitor activity 4/425 14/18639 0.285714285714286 12.5304201680672 0.000222507012713804 0.00467882801734305 GO:0004129 cytochrome-c oxidase activity 4/425 15/18639 0.266666666666667 11.6950588235294 0.000297975216559301 0.00600920525655829 GO:0016504 peptidase activator activity 7/425 57/18639 0.12280701754386 5.38588235294118 0.000301650990421685 0.00600920525655829 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/425 16/18639 0.25 10.9641176470588 0.000390178000238932 0.00757345503027875 GO:0019955 cytokine binding 11/425 144/18639 0.0763888888888889 3.35014705882353 0.000471400142308247 0.00872714492607028 GO:0048306 calcium-dependent protein binding 8/425 80/18639 0.1 4.38564705882353 0.000472672314357835 0.00872714492607028 GO:0098641 cadherin binding involved in cell-cell adhesion 4/425 18/18639 0.222222222222222 9.74588235294118 0.000632730557239472 0.0114042150435781 GO:0045296 cadherin binding 18/425 334/18639 0.0538922155688623 2.36352236703064 0.000702333027848819 0.012364327955385 GO:0016209 antioxidant activity 8/425 86/18639 0.0930232558139535 4.07967168262654 0.000768606307349268 0.0132235221514408 GO:0140375 immune receptor activity 11/425 156/18639 0.0705128205128205 3.09244343891403 0.000920143419752005 0.0154788570833837 GO:0004867 serine-type endopeptidase inhibitor activity 8/425 95/18639 0.0842105263157895 3.69317647058824 0.00147481982491487 0.024270404510012 GO:0004602 glutathione peroxidase activity 4/425 23/18639 0.173913043478261 7.62721227621483 0.00167324019915495 0.0256583844249503 GO:0050786 RAGE receptor binding 3/425 11/18639 0.272727272727273 11.9608556149733 0.00169474137549209 0.0256583844249503 GO:0050998 nitric-oxide synthase binding 3/425 11/18639 0.272727272727273 11.9608556149733 0.00169474137549209 0.0256583844249503 GO:1990948 ubiquitin ligase inhibitor activity 3/425 11/18639 0.272727272727273 11.9608556149733 0.00169474137549209 0.0256583844249503 GO:0033293 monocarboxylic acid binding 7/425 79/18639 0.0886075949367089 3.88601638123604 0.00215586364550604 0.0319997799930994 GO:0042287 MHC protein binding 5/425 41/18639 0.121951219512195 5.34835007173601 0.00229522730603491 0.0329361394245934 GO:0120020 cholesterol transfer activity 4/425 25/18639 0.16 7.01703529411765 0.0023059648474286 0.0329361394245934 GO:0008307 structural constituent of muscle 5/425 42/18639 0.119047619047619 5.22100840336134 0.00255740999246108 0.0351992611689643 GO:0042056 chemoattractant activity 5/425 42/18639 0.119047619047619 5.22100840336134 0.00255740999246108 0.0351992611689643 GO:0023026 MHC class II protein complex binding 4/425 27/18639 0.148148148148148 6.49725490196078 0.00308643320106627 0.0417219630929851 GO:0030547 signaling receptor inhibitor activity 5/425 44/18639 0.113636363636364 4.98368983957219 0.0031458794736645 0.041779487044983 GO:0044548 S100 protein binding 3/425 14/18639 0.214285714285714 9.39781512605042 0.00355330155447296 0.0463767116678626 GO:0031406 carboxylic acid binding 11/425 187/18639 0.0588235294117647 2.57979238754325 0.00384826775465528 0.0493752320385431 GO:0043236 laminin binding 4/425 29/18639 0.137931034482759 6.04916835699797 0.00402999631492837 0.0508451201733463 GO:0043177 organic acid binding 11/425 189/18639 0.0582010582010582 2.55249299719888 0.00416934395572024 0.0513170130878319 GO:0005504 fatty acid binding 5/425 47/18639 0.106382978723404 4.66558197747184 0.00420297861485545 0.0513170130878319 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/425 15/18639 0.2 8.77129411764706 0.00436713313895137 0.0524749172410506 GO:0032934 sterol binding 6/425 68/18639 0.0882352941176471 3.86968858131488 0.00451143568804823 0.0533618252476955 GO:0001221 transcription coregulator binding 8/425 115/18639 0.0695652173913043 3.05088491048593 0.00484933710568356 0.0564761259846531 GO:0005006 epidermal growth factor receptor activity 5/425 50/18639 0.1 4.38564705882353 0.00549181125146135 0.0616584362935268 GO:0042562 hormone binding 7/425 94/18639 0.074468085106383 3.26590738423029 0.00569751730767634 0.0616584362935268 GO:0030515 snoRNA binding 4/425 32/18639 0.125 5.48205882352941 0.00578302374747742 0.0616584362935268 GO:0071813 lipoprotein particle binding 4/425 32/18639 0.125 5.48205882352941 0.00578302374747742 0.0616584362935268 GO:0071814 protein-lipid complex binding 4/425 32/18639 0.125 5.48205882352941 0.00578302374747742 0.0616584362935268 GO:0120015 sterol transfer activity 4/425 32/18639 0.125 5.48205882352941 0.00578302374747742 0.0616584362935268 GO:0004896 cytokine receptor activity 7/425 96/18639 0.0729166666666667 3.19786764705882 0.00638387292066135 0.06711933056862 GO:0016860 intramolecular oxidoreductase activity 5/425 53/18639 0.0943396226415094 4.13740288568258 0.0070371706775318 0.0729744959300216 GO:0015485 cholesterol binding 5/425 54/18639 0.0925925925925926 4.06078431372549 0.00761346921395685 0.077375027003664 GO:0005125 cytokine activity 12/425 234/18639 0.0512820512820513 2.24904977375566 0.00766595379824941 0.077375027003664 GO:0098632 cell-cell adhesion mediator activity 5/425 55/18639 0.0909090909090909 3.98695187165775 0.00822180604189841 0.081893515443646 GO:0019199 transmembrane receptor protein kinase activity 6/425 78/18639 0.0769230769230769 3.37357466063348 0.00876231715877675 0.0856110111911753 GO:0055106 ubiquitin-protein transferase regulator activity 4/425 36/18639 0.111111111111111 4.87294117647059 0.00882121383475783 0.0856110111911753 GO:0004601 peroxidase activity 5/425 57/18639 0.087719298245614 3.84705882352941 0.00953796908340081 0.0913954759004356 GO:0023023 MHC protein complex binding 4/425 37/18639 0.108108108108108 4.741240063593 0.00971611751777566 0.0919387620119522 GO:0042288 MHC class I protein binding 3/425 20/18639 0.15 6.57847058823529 0.0100575656736804 0.0939947804318032 GO:0005501 retinoid binding 4/425 38/18639 0.105263157894737 4.61647058823529 0.0106679427845956 0.0972967793727573 GO:0019840 isoprenoid binding 4/425 38/18639 0.105263157894737 4.61647058823529 0.0106679427845956 0.0972967793727573 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/425 59/18639 0.0847457627118644 3.71665004985045 0.0109922429458782 0.0990610465479741 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/425 60/18639 0.0833333333333333 3.65470588235294 0.0117731510418147 0.104406003240615 GO:0005496 steroid binding 7/425 108/18639 0.0648148148148148 2.84254901960784 0.0118611839877053 0.104406003240615 GO:0008083 growth factor activity 9/425 162/18639 0.0555555555555556 2.43647058823529 0.0121524314259162 0.105740121717454 GO:0005200 structural constituent of cytoskeleton 7/425 112/18639 0.0625 2.74102941176471 0.014275466630091 0.122801457261124 GO:0017134 fibroblast growth factor binding 3/425 23/18639 0.130434782608696 5.72040920716112 0.0148578033307812 0.12637479911687 GO:0004197 cysteine-type endopeptidase activity 6/425 88/18639 0.0681818181818182 2.99021390374332 0.0153161563005396 0.128825892438983 GO:0038024 cargo receptor activity 5/425 65/18639 0.0769230769230769 3.37357466063348 0.016245093880193 0.133668870296805 GO:0120013 lipid transfer activity 5/425 65/18639 0.0769230769230769 3.37357466063348 0.016245093880193 0.133668870296805 GO:0050431 transforming growth factor beta binding 3/425 24/18639 0.125 5.48205882352941 0.0166986157012215 0.135923140707792 GO:0072341 modified amino acid binding 6/425 91/18639 0.0659340659340659 2.89163542340013 0.017807876451231 0.143410239080658 GO:0043178 alcohol binding 6/425 92/18639 0.0652173913043478 2.86020460358056 0.0186967107350457 0.148457467367636 GO:0008009 chemokine activity 4/425 45/18639 0.0888888888888889 3.89835294117647 0.0190229515649415 0.148457467367636 GO:0042605 peptide antigen binding 4/425 45/18639 0.0888888888888889 3.89835294117647 0.0190229515649415 0.148457467367636 GO:0016410 N-acyltransferase activity 6/425 94/18639 0.0638297872340425 2.7993491864831 0.0205643396586386 0.152474379452392 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/425 10/18639 0.2 8.77129411764706 0.0206788337914455 0.152474379452392 GO:0005381 iron ion transmembrane transporter activity 2/425 10/18639 0.2 8.77129411764706 0.0206788337914455 0.152474379452392 GO:0008198 ferrous iron binding 3/425 26/18639 0.115384615384615 5.06036199095023 0.020746183729982 0.152474379452392 GO:0019865 immunoglobulin binding 3/425 26/18639 0.115384615384615 5.06036199095023 0.020746183729982 0.152474379452392 GO:0043548 phosphatidylinositol 3-kinase binding 3/425 26/18639 0.115384615384615 5.06036199095023 0.020746183729982 0.152474379452392 GO:0051082 unfolded protein binding 7/425 121/18639 0.0578512396694215 2.53715119105493 0.0209547313174811 0.152526265455127 GO:0097110 scaffold protein binding 5/425 70/18639 0.0714285714285714 3.13260504201681 0.0217241901019165 0.156621065782389 GO:0004175 endopeptidase activity 16/425 405/18639 0.0395061728395062 1.73260130718954 0.024113090246771 0.157720547120934 GO:0003953 NAD+ nucleosidase activity 2/425 11/18639 0.181818181818182 7.97390374331551 0.0248975209949907 0.157720547120934 GO:0008199 ferric iron binding 2/425 11/18639 0.181818181818182 7.97390374331551 0.0248975209949907 0.157720547120934 GO:0019864 IgG binding 2/425 11/18639 0.181818181818182 7.97390374331551 0.0248975209949907 0.157720547120934 GO:0034511 U3 snoRNA binding 2/425 11/18639 0.181818181818182 7.97390374331551 0.0248975209949907 0.157720547120934 GO:0097493 structural molecule activity conferring elasticity 2/425 11/18639 0.181818181818182 7.97390374331551 0.0248975209949907 0.157720547120934 GO:0005004 GPI-linked ephrin receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005008 hepatocyte growth factor receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005009 insulin receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005011 macrophage colony-stimulating factor receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005020 stem cell factor receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0008288 boss receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0036332 placental growth factor receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0038062 protein tyrosine kinase collagen receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0060175 brain-derived neurotrophic factor receptor activity 4/425 49/18639 0.0816326530612245 3.58012004801921 0.0252102856032141 0.157720547120934 GO:0005007 fibroblast growth factor receptor activity 4/425 50/18639 0.08 3.50851764705882 0.0269249355468447 0.164372388781947 GO:0005017 platelet-derived growth factor receptor activity 4/425 50/18639 0.08 3.50851764705882 0.0269249355468447 0.164372388781947 GO:0005019 platelet-derived growth factor beta-receptor activity 4/425 50/18639 0.08 3.50851764705882 0.0269249355468447 0.164372388781947 GO:0003725 double-stranded RNA binding 5/425 75/18639 0.0666666666666667 2.92376470588235 0.0282822505541106 0.169779247194699 GO:0005010 insulin-like growth factor receptor activity 4/425 51/18639 0.0784313725490196 3.439723183391 0.0287077194728157 0.169779247194699 GO:0005021 vascular endothelial growth factor receptor activity 4/425 51/18639 0.0784313725490196 3.439723183391 0.0287077194728157 0.169779247194699 GO:0005030 neurotrophin receptor activity 4/425 51/18639 0.0784313725490196 3.439723183391 0.0287077194728157 0.169779247194699 GO:0004859 phospholipase inhibitor activity 2/425 12/18639 0.166666666666667 7.30941176470588 0.0294327003268887 0.170488648656583 GO:0097371 MDM2/MDM4 family protein binding 2/425 12/18639 0.166666666666667 7.30941176470588 0.0294327003268887 0.170488648656583 GO:0017022 myosin binding 5/425 76/18639 0.0657894736842105 2.88529411764706 0.0297285358291532 0.170488648656583 GO:0098631 cell adhesion mediator activity 5/425 76/18639 0.0657894736842105 2.88529411764706 0.0297285358291532 0.170488648656583 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 14/425 349/18639 0.0401146131805158 1.75928535310973 0.0299636909372919 0.170545218342331 GO:0031210 phosphatidylcholine binding 3/425 30/18639 0.1 4.38564705882353 0.0303102828025104 0.171230478220152 GO:0005080 protein kinase C binding 4/425 52/18639 0.0769230769230769 3.37357466063348 0.0305590254394103 0.171356905612101 GO:0005003 ephrin receptor activity 4/425 53/18639 0.0754716981132075 3.30992230854606 0.0324791768485432 0.176882999096023 GO:0005005 transmembrane-ephrin receptor activity 4/425 53/18639 0.0754716981132075 3.30992230854606 0.0324791768485432 0.176882999096023 GO:0017046 peptide hormone binding 4/425 53/18639 0.0754716981132075 3.30992230854606 0.0324791768485432 0.176882999096023 GO:0038064 collagen receptor activity 4/425 53/18639 0.0754716981132075 3.30992230854606 0.0324791768485432 0.176882999096023 GO:0008035 high-density lipoprotein particle binding 2/425 13/18639 0.153846153846154 6.74714932126697 0.0342678167741497 0.185290980700224 GO:0140313 molecular sequestering activity 4/425 55/18639 0.0727272727272727 3.1895614973262 0.0365269924724404 0.196105909940691 GO:0005161 platelet-derived growth factor receptor binding 2/425 14/18639 0.142857142857143 6.26521008403361 0.0393869026440958 0.208502694416647 GO:0032036 myosin heavy chain binding 2/425 14/18639 0.142857142857143 6.26521008403361 0.0393869026440958 0.208502694416647 GO:0004222 metalloendopeptidase activity 6/425 110/18639 0.0545454545454545 2.39217112299465 0.0401553620738282 0.211094507568666 GO:0008135 translation factor activity, RNA binding 5/425 83/18639 0.0602409638554217 2.64195605953225 0.0411522516049005 0.214843134240756 GO:0015035 protein-disulfide reductase activity 3/425 34/18639 0.0882352941176471 3.86968858131488 0.0418121155409376 0.216792955236231 GO:0180051 translation factor activity 5/425 84/18639 0.0595238095238095 2.61050420168067 0.0429729788620982 0.221296224480329 GO:0005523 tropomyosin binding 2/425 15/18639 0.133333333333333 5.84752941176471 0.0447745594910411 0.22747880224643 GO:0051371 muscle alpha-actinin binding 2/425 15/18639 0.133333333333333 5.84752941176471 0.0447745594910411 0.22747880224643 GO:0001786 phosphatidylserine binding 4/425 59/18639 0.0677966101694915 2.97332003988036 0.045456072928064 0.22940164804363 GO:0003779 actin binding 16/425 443/18639 0.036117381489842 1.58398087903333 0.0481927441881753 0.241602035433435 GO:0004252 serine-type endopeptidase activity 8/425 176/18639 0.0454545454545455 1.99347593582888 0.0490157712198607 0.24411143956207 GO:0008142 oxysterol binding 2/425 16/18639 0.125 5.48205882352941 0.0504159405587447 0.24464658335237 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/425 16/18639 0.125 5.48205882352941 0.0504159405587447 0.24464658335237 GO:0055102 lipase inhibitor activity 2/425 16/18639 0.125 5.48205882352941 0.0504159405587447 0.24464658335237 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/425 16/18639 0.125 5.48205882352941 0.0504159405587447 0.24464658335237 GO:0005126 cytokine receptor binding 11/425 275/18639 0.04 1.75425882352941 0.0513895746500601 0.247782853567487 GO:0005507 copper ion binding 4/425 63/18639 0.0634920634920635 2.78453781512605 0.0554943297821224 0.261451702021599 GO:0008429 phosphatidylethanolamine binding 2/425 17/18639 0.117647058823529 5.15958477508651 0.056296733724598 0.261451702021599 GO:0030169 low-density lipoprotein particle binding 2/425 17/18639 0.117647058823529 5.15958477508651 0.056296733724598 0.261451702021599 GO:0038191 neuropilin binding 2/425 17/18639 0.117647058823529 5.15958477508651 0.056296733724598 0.261451702021599 GO:0048038 quinone binding 2/425 17/18639 0.117647058823529 5.15958477508651 0.056296733724598 0.261451702021599 GO:0070492 oligosaccharide binding 2/425 17/18639 0.117647058823529 5.15958477508651 0.056296733724598 0.261451702021599 GO:0000217 DNA secondary structure binding 3/425 39/18639 0.0769230769230769 3.37357466063348 0.0588136692930163 0.27147529057813 GO:0022804 active transmembrane transporter activity 16/425 457/18639 0.0350109409190372 1.5354563006822 0.0603192889384493 0.275831738162787 GO:0008237 metallopeptidase activity 8/425 184/18639 0.0434782608695652 1.90680306905371 0.060486219993425 0.275831738162787 GO:0035615 clathrin adaptor activity 2/425 18/18639 0.111111111111111 4.87294117647059 0.062403144931877 0.278526008108014 GO:1990381 ubiquitin-specific protease binding 2/425 18/18639 0.111111111111111 4.87294117647059 0.062403144931877 0.278526008108014 GO:0015036 disulfide oxidoreductase activity 3/425 40/18639 0.075 3.28923529411765 0.0625487732871365 0.278526008108014 GO:0050997 quaternary ammonium group binding 3/425 40/18639 0.075 3.28923529411765 0.0625487732871365 0.278526008108014 GO:0005543 phospholipid binding 17/425 497/18639 0.03420523138833 1.50012072434608 0.0641514233970344 0.283991973751784 GO:0008234 cysteine-type peptidase activity 8/425 187/18639 0.0427807486631016 1.876212645486 0.065188001780011 0.286903007834118 GO:0044389 ubiquitin-like protein ligase binding 12/425 322/18639 0.0372670807453416 1.63440263061746 0.0663510578630309 0.289866157051639 GO:0016500 protein-hormone receptor activity 4/425 67/18639 0.0597014925373134 2.61829675153644 0.066627095544234 0.289866157051639 GO:0003756 protein disulfide isomerase activity 2/425 19/18639 0.105263157894737 4.61647058823529 0.0687218820967514 0.290628294677323 GO:0008301 DNA binding, bending 2/425 19/18639 0.105263157894737 4.61647058823529 0.0687218820967514 0.290628294677323 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/425 19/18639 0.105263157894737 4.61647058823529 0.0687218820967514 0.290628294677323 GO:0016918 retinal binding 2/425 19/18639 0.105263157894737 4.61647058823529 0.0687218820967514 0.290628294677323 GO:0097001 ceramide binding 2/425 19/18639 0.105263157894737 4.61647058823529 0.0687218820967514 0.290628294677323 GO:0008080 N-acetyltransferase activity 4/425 69/18639 0.0579710144927536 2.54240409207161 0.0725958589767876 0.305305918030157 GO:0048156 tau protein binding 3/425 43/18639 0.0697674418604651 3.0597537619699 0.0743903273242311 0.311124186654381 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/425 20/18639 0.1 4.38564705882353 0.0752401394770927 0.312949371341534 GO:0008236 serine-type peptidase activity 8/425 194/18639 0.0412371134020619 1.80851425106125 0.0770185875865804 0.318596015317166 GO:0001223 transcription coactivator binding 3/425 44/18639 0.0681818181818182 2.99021390374332 0.0785427297736339 0.321388359127789 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/425 44/18639 0.0681818181818182 2.99021390374332 0.0785427297736339 0.321388359127789 GO:0001664 G protein-coupled receptor binding 11/425 297/18639 0.037037037037037 1.6243137254902 0.079102135138761 0.321937184408828 GO:0051010 microtubule plus-end binding 2/425 21/18639 0.0952380952380952 4.17680672268908 0.0819455824904655 0.326863247796121 GO:0072542 protein phosphatase activator activity 2/425 21/18639 0.0952380952380952 4.17680672268908 0.0819455824904655 0.326863247796121 GO:0140312 cargo adaptor activity 2/425 21/18639 0.0952380952380952 4.17680672268908 0.0819455824904655 0.326863247796121 GO:0042379 chemokine receptor binding 4/425 72/18639 0.0555555555555556 2.43647058823529 0.0820396526833064 0.326863247796121 GO:0017171 serine hydrolase activity 8/425 198/18639 0.0404040404040404 1.77197860962567 0.0843210842148724 0.334194035343761 GO:0008649 rRNA methyltransferase activity 2/425 22/18639 0.0909090909090909 3.98695187165775 0.0888263329690203 0.346605845657466 GO:0070034 telomerase RNA binding 2/425 22/18639 0.0909090909090909 3.98695187165775 0.0888263329690203 0.346605845657466 GO:0140035 ubiquitin-like protein reader activity 2/425 22/18639 0.0909090909090909 3.98695187165775 0.0888263329690203 0.346605845657466 GO:0061733 protein-lysine-acetyltransferase activity 3/425 47/18639 0.0638297872340425 2.7993491864831 0.0915849659830743 0.355537534611217 GO:0016922 nuclear receptor binding 6/425 137/18639 0.0437956204379562 1.92072133963074 0.0937874060405888 0.361958897069457 GO:0140297 DNA-binding transcription factor binding 16/425 488/18639 0.0327868852459016 1.43791706846673 0.0941953800828046 0.361958897069457 GO:0005212 structural constituent of eye lens 2/425 23/18639 0.0869565217391304 3.81360613810742 0.0958709548393288 0.362871564066859 GO:0031681 G-protein beta-subunit binding 2/425 23/18639 0.0869565217391304 3.81360613810742 0.0958709548393288 0.362871564066859 GO:0140102 catalytic activity, acting on a rRNA 2/425 23/18639 0.0869565217391304 3.81360613810742 0.0958709548393288 0.362871564066859 GO:0001222 transcription corepressor binding 3/425 49/18639 0.0612244897959184 2.68509003601441 0.100744272456518 0.379419971390965 GO:0035035 histone acetyltransferase binding 2/425 24/18639 0.0833333333333333 3.65470588235294 0.10306844021552 0.386251530906678 GO:0048020 CCR chemokine receptor binding 3/425 50/18639 0.06 2.63138823529412 0.10545614502522 0.393252718148235 GO:0051015 actin filament binding 8/425 209/18639 0.0382775119617225 1.67871657754011 0.106423652334908 0.394915219693751 GO:0003743 translation initiation factor activity 3/425 51/18639 0.0588235294117647 2.57979238754325 0.110252921622245 0.403763305758699 GO:0001848 complement binding 2/425 25/18639 0.08 3.50851764705882 0.110408195894387 0.403763305758699 GO:0019211 phosphatase activator activity 2/425 25/18639 0.08 3.50851764705882 0.110408195894387 0.403763305758699 GO:0001618 virus receptor activity 4/425 81/18639 0.0493827160493827 2.16575163398693 0.113722666068435 0.413884895258678 GO:0140272 exogenous protein binding 4/425 82/18639 0.0487804878048781 2.1393400286944 0.117535154726564 0.422773035142814 GO:0050681 nuclear androgen receptor binding 2/425 26/18639 0.0769230769230769 3.37357466063348 0.11788003024142 0.422773035142814 GO:0120014 phospholipid transfer activity 2/425 26/18639 0.0769230769230769 3.37357466063348 0.11788003024142 0.422773035142814 GO:0016853 isomerase activity 7/425 180/18639 0.0388888888888889 1.70552941176471 0.118398789234183 0.422773035142814 GO:0034212 protein N-acetyltransferase activity 3/425 53/18639 0.0566037735849057 2.48244173140955 0.120091317530329 0.424809006404015 GO:0140296 general transcription initiation factor binding 3/425 53/18639 0.0566037735849057 2.48244173140955 0.120091317530329 0.424809006404015 GO:0019207 kinase regulator activity 10/425 287/18639 0.0348432055749129 1.528100020496 0.122275036075548 0.430521871205535 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/425 54/18639 0.0555555555555556 2.43647058823529 0.125127957769801 0.433716549433718 GO:0051117 ATPase binding 4/425 84/18639 0.0476190476190476 2.08840336134454 0.125324126723724 0.433716549433718 GO:0004364 glutathione transferase activity 2/425 27/18639 0.0740740740740741 3.24862745098039 0.125474140457046 0.433716549433718 GO:0035255 ionotropic glutamate receptor binding 2/425 27/18639 0.0740740740740741 3.24862745098039 0.125474140457046 0.433716549433718 GO:0019887 protein kinase regulator activity 9/425 255/18639 0.0352941176470588 1.54787543252595 0.130287034981715 0.448305843096172 GO:0045499 chemorepellent activity 2/425 28/18639 0.0714285714285714 3.13260504201681 0.13318110021259 0.450080771700582 GO:0046625 sphingolipid binding 2/425 28/18639 0.0714285714285714 3.13260504201681 0.13318110021259 0.450080771700582 GO:0051393 alpha-actinin binding 2/425 28/18639 0.0714285714285714 3.13260504201681 0.13318110021259 0.450080771700582 GO:0097718 disordered domain specific binding 2/425 28/18639 0.0714285714285714 3.13260504201681 0.13318110021259 0.450080771700582 GO:0051861 glycolipid binding 2/425 29/18639 0.0689655172413793 3.02458417849899 0.140991847645802 0.474359238523878 GO:0003727 single-stranded RNA binding 4/425 89/18639 0.0449438202247191 1.97107732980833 0.14570494718037 0.488047101838674 GO:0048019 receptor antagonist activity 2/425 30/18639 0.0666666666666667 2.92376470588235 0.148897673706038 0.49654422464965 GO:0031625 ubiquitin protein ligase binding 10/425 302/18639 0.033112582781457 1.45220101285547 0.154025248661865 0.511390847530843 GO:0072349 modified amino acid transmembrane transporter activity 2/425 31/18639 0.0645161290322581 2.82944971537002 0.156890210839429 0.518628338888418 GO:0043425 bHLH transcription factor binding 2/425 32/18639 0.0625 2.74102941176471 0.164961422004685 0.542938245467593 GO:0030296 protein tyrosine kinase activator activity 2/425 33/18639 0.0606060606060606 2.6579679144385 0.173103590010358 0.564825076025176 GO:0140311 protein sequestering activity 2/425 33/18639 0.0606060606060606 2.6579679144385 0.173103590010358 0.564825076025176 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/425 130/18639 0.0384615384615385 1.68678733031674 0.176140057600852 0.57002800582669 GO:0016407 acetyltransferase activity 4/425 96/18639 0.0416666666666667 1.82735294117647 0.176204165605608 0.57002800582669 GO:0008376 acetylgalactosaminyltransferase activity 2/425 34/18639 0.0588235294117647 2.57979238754325 0.181309307164697 0.578230553376443 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/425 34/18639 0.0588235294117647 2.57979238754325 0.181309307164697 0.578230553376443 GO:0051427 hormone receptor binding 2/425 34/18639 0.0588235294117647 2.57979238754325 0.181309307164697 0.578230553376443 GO:0010485 histone H4 acetyltransferase activity 2/425 35/18639 0.0571428571428571 2.50608403361345 0.189571465229418 0.578230553376443 GO:0034061 DNA polymerase activity 2/425 35/18639 0.0571428571428571 2.50608403361345 0.189571465229418 0.578230553376443 GO:0030246 carbohydrate binding 9/425 280/18639 0.0321428571428571 1.40967226890756 0.191274749693084 0.578230553376443 GO:0005516 calmodulin binding 7/425 207/18639 0.0338164251207729 1.48306905370844 0.195076184864551 0.578230553376443 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/425 36/18639 0.0555555555555556 2.43647058823529 0.197883245668972 0.578230553376443 GO:1990841 promoter-specific chromatin binding 3/425 68/18639 0.0441176470588235 1.93484429065744 0.202369454829024 0.578230553376443 GO:0008238 exopeptidase activity 4/425 102/18639 0.0392156862745098 1.7198615916955 0.203903905647706 0.578230553376443 GO:0001094 TFIID-class transcription factor complex binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0003796 lysozyme activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0004935 adrenergic receptor activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0004955 prostaglandin receptor activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0005131 growth hormone receptor binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0008190 eukaryotic initiation factor 4E binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0015187 glycine transmembrane transporter activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0030957 Tat protein binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0031720 haptoglobin binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0032395 MHC class II receptor activity 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0033204 ribonuclease P RNA binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0035374 chondroitin sulfate binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0042975 peroxisome proliferator activated receptor binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0043121 neurotrophin binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0043208 glycosphingolipid binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0043295 glutathione binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0070513 death domain binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0099122 RNA polymerase II C-terminal domain binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:1905394 retromer complex binding 1/425 10/18639 0.1 4.38564705882353 0.206032427930228 0.578230553376443 GO:0042805 actinin binding 2/425 37/18639 0.0540540540540541 2.3706200317965 0.206238110187106 0.578230553376443 GO:0003823 antigen binding 6/425 174/18639 0.0344827586206897 1.51229208924949 0.207171877356725 0.578705207228932 GO:0140104 molecular carrier activity 8/425 249/18639 0.0321285140562249 1.40904323175053 0.209789081673198 0.583087492777251 GO:0030295 protein kinase activator activity 5/425 139/18639 0.0359712230215827 1.5775708844689 0.211683578914666 0.583087492777251 GO:0004713 protein tyrosine kinase activity 5/425 140/18639 0.0357142857142857 1.5663025210084 0.215769260332797 0.583087492777251 GO:0005319 lipid transporter activity 6/425 178/18639 0.0337078651685393 1.47830799735625 0.22163025410802 0.583087492777251 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/425 39/18639 0.0512820512820513 2.24904977375566 0.223052284637306 0.583087492777251 GO:0046982 protein heterodimerization activity 11/425 369/18639 0.029810298102981 1.30737446197991 0.223425972878726 0.583087492777251 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0001851 complement component C3b binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0004954 prostanoid receptor activity 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0008432 JUN kinase binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0008526 phosphatidylinositol transfer activity 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0019107 myristoyltransferase activity 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0032050 clathrin heavy chain binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0034713 type I transforming growth factor beta receptor binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0042608 T cell receptor binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0048185 activin binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:1900750 oligopeptide binding 1/425 11/18639 0.0909090909090909 3.98695187165775 0.224145918623752 0.583087492777251 GO:0019888 protein phosphatase regulator activity 4/425 107/18639 0.0373831775700935 1.63949422759758 0.227891059051421 0.589558314481346 GO:0003713 transcription coactivator activity 8/425 256/18639 0.03125 1.37051470588235 0.231013775611958 0.589558314481346 GO:0004177 aminopeptidase activity 2/425 40/18639 0.05 2.19282352941176 0.231499837866262 0.589558314481346 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/425 40/18639 0.05 2.19282352941176 0.231499837866262 0.589558314481346 GO:0004521 RNA endonuclease activity 3/425 73/18639 0.0410958904109589 1.80232070910556 0.232220835477229 0.589558314481346 GO:0019903 protein phosphatase binding 5/425 144/18639 0.0347222222222222 1.52279411764706 0.232351569767294 0.589558314481346 GO:0003684 damaged DNA binding 3/425 74/18639 0.0405405405405405 1.77796502384738 0.238287000128648 0.589558314481346 GO:0003720 telomerase activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0004300 enoyl-CoA hydratase activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0004526 ribonuclease P activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0004875 complement receptor activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0005095 GTPase inhibitor activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0008179 adenylate cyclase binding 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0017166 vinculin binding 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0031543 peptidyl-proline dioxygenase activity 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0045295 gamma-catenin binding 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0097677 STAT family protein binding 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:1990459 transferrin receptor binding 1/425 12/18639 0.0833333333333333 3.65470588235294 0.241847120287103 0.589558314481346 GO:0019003 GDP binding 3/425 75/18639 0.04 1.75425882352941 0.24437994942843 0.589558314481346 GO:0044183 protein folding chaperone 3/425 75/18639 0.04 1.75425882352941 0.24437994942843 0.589558314481346 GO:0004402 histone acetyltransferase activity 2/425 42/18639 0.0476190476190476 2.08840336134454 0.248448335676142 0.589558314481346 GO:0019894 kinesin binding 2/425 42/18639 0.0476190476190476 2.08840336134454 0.248448335676142 0.589558314481346 GO:0019209 kinase activator activity 5/425 148/18639 0.0337837837837838 1.48163751987281 0.249282566845592 0.589558314481346 GO:0008200 ion channel inhibitor activity 2/425 43/18639 0.0465116279069767 2.03983584131327 0.256938970229894 0.589558314481346 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/425 43/18639 0.0465116279069767 2.03983584131327 0.256938970229894 0.589558314481346 GO:0140597 protein carrier chaperone 6/425 188/18639 0.0319148936170213 1.39967459324155 0.259123519136083 0.589558314481346 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0003964 RNA-directed DNA polymerase activity 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0005172 vascular endothelial growth factor receptor binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0005542 folic acid binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0009982 pseudouridine synthase activity 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0035325 Toll-like receptor binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0035673 oligopeptide transmembrane transporter activity 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0039706 co-receptor binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0043560 insulin receptor substrate binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0045159 myosin II binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:1901338 catecholamine binding 1/425 13/18639 0.0769230769230769 3.37357466063348 0.259145395579849 0.589558314481346 GO:0000510 H3-H4 histone complex chaperone activity 5/425 151/18639 0.033112582781457 1.45220101285547 0.262181780048188 0.589558314481346 GO:0140584 chromatin extrusion motor activity 5/425 151/18639 0.033112582781457 1.45220101285547 0.262181780048188 0.589558314481346 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/425 151/18639 0.033112582781457 1.45220101285547 0.262181780048188 0.589558314481346 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/425 151/18639 0.033112582781457 1.45220101285547 0.262181780048188 0.589558314481346 GO:0016248 channel inhibitor activity 2/425 44/18639 0.0454545454545455 1.99347593582888 0.26543402929924 0.589558314481346 GO:0015616 DNA translocase activity 5/425 152/18639 0.0328947368421053 1.44264705882353 0.266515942093871 0.589558314481346 GO:0140674 ATP-dependent histone chaperone activity 5/425 152/18639 0.0328947368421053 1.44264705882353 0.266515942093871 0.589558314481346 GO:0035401 histone H3Y41 kinase activity 4/425 115/18639 0.0347826086956522 1.52544245524297 0.267592365515758 0.589558314481346 GO:0140801 histone H2AXY142 kinase activity 4/425 115/18639 0.0347826086956522 1.52544245524297 0.267592365515758 0.589558314481346 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/425 229/18639 0.0305676855895196 1.34059080400719 0.268737958889893 0.589558314481346 GO:0046332 SMAD binding 3/425 79/18639 0.0379746835443038 1.6654355919583 0.268976997890766 0.589558314481346 GO:0061775 cohesin loader activity 5/425 153/18639 0.0326797385620915 1.43321799307958 0.270866116015671 0.589558314481346 GO:0046915 transition metal ion transmembrane transporter activity 2/425 45/18639 0.0444444444444444 1.94917647058824 0.273928907754887 0.589558314481346 GO:0141110 transporter inhibitor activity 2/425 45/18639 0.0444444444444444 1.94917647058824 0.273928907754887 0.589558314481346 GO:0004065 arylsulfatase activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0004705 JUN kinase activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0005344 oxygen carrier activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0008195 phosphatidate phosphatase activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0008494 translation activator activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0019763 immunoglobulin receptor activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0019992 diacylglycerol binding 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0043176 amine binding 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0061783 peptidoglycan muralytic activity 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0098847 sequence-specific single stranded DNA binding 1/425 14/18639 0.0714285714285714 3.13260504201681 0.276049895036446 0.589558314481346 GO:0019208 phosphatase regulator activity 4/425 117/18639 0.0341880341880342 1.4993665158371 0.277714160473856 0.589558314481346 GO:0004180 carboxypeptidase activity 2/425 46/18639 0.0434782608695652 1.90680306905371 0.282419207214623 0.589558314481346 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/425 46/18639 0.0434782608695652 1.90680306905371 0.282419207214623 0.589558314481346 GO:0030276 clathrin binding 2/425 46/18639 0.0434782608695652 1.90680306905371 0.282419207214623 0.589558314481346 GO:0030291 protein serine/threonine kinase inhibitor activity 2/425 46/18639 0.0434782608695652 1.90680306905371 0.282419207214623 0.589558314481346 GO:0004559 alpha-mannosidase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0004953 icosanoid receptor activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0005041 low-density lipoprotein particle receptor activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0015929 hexosaminidase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0016846 carbon-sulfur lyase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0031386 protein tag activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0033130 acetylcholine receptor binding 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0045504 dynein heavy chain binding 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0047372 monoacylglycerol lipase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0061578 K63-linked deubiquitinase activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0120283 protein serine/threonine kinase binding 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0140161 monocarboxylate:sodium symporter activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0141047 molecular tag activity 1/425 15/18639 0.0666666666666667 2.92376470588235 0.292569561861117 0.589558314481346 GO:0140658 ATP-dependent chromatin remodeler activity 5/425 158/18639 0.0316455696202532 1.38786299329859 0.292832135066032 0.589558314481346 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/425 48/18639 0.0416666666666667 1.82735294117647 0.299369467586178 0.596162868411373 GO:0004860 protein kinase inhibitor activity 3/425 84/18639 0.0357142857142857 1.5663025210084 0.300077589402646 0.596162868411373 GO:0003689 DNA clamp loader activity 5/425 160/18639 0.03125 1.37051470588235 0.301705711151827 0.596162868411373 GO:0035254 glutamate receptor binding 2/425 49/18639 0.0408163265306122 1.7900600240096 0.307821603549142 0.596162868411373 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0004707 MAP kinase activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0005024 transforming growth factor beta receptor activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0005159 insulin-like growth factor receptor binding 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0005521 lamin binding 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0015378 sodium:chloride symporter activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0015562 efflux transmembrane transporter activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0015923 mannosidase activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0016722 oxidoreductase activity, acting on metal ions 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0019841 retinol binding 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0022858 alanine transmembrane transporter activity 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/425 16/18639 0.0625 2.74102941176471 0.308713136614608 0.596162868411373 GO:0050660 flavin adenine dinucleotide binding 3/425 86/18639 0.0348837209302326 1.52987688098495 0.312578637368637 0.602054645781844 GO:0140713 histone chaperone activity 5/425 164/18639 0.0304878048780488 1.337087517934 0.31957154892717 0.602054645781844 GO:0035091 phosphatidylinositol binding 8/425 284/18639 0.028169014084507 1.23539353769677 0.3221684308565 0.602054645781844 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0004549 tRNA-specific ribonuclease activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0008484 sulfuric ester hydrolase activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0015278 intracellularly gated calcium channel activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0016018 cyclosporin A binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0030548 acetylcholine receptor regulator activity 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0031489 myosin V binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0036041 long-chain fatty acid binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0046965 nuclear retinoid X receptor binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0051787 misfolded protein binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0070403 NAD+ binding 1/425 17/18639 0.0588235294117647 2.57979238754325 0.324489161795234 0.602054645781844 GO:0004519 endonuclease activity 4/425 127/18639 0.031496062992126 1.38130616025938 0.329059729808947 0.603820532380283 GO:0031490 chromatin DNA binding 4/425 128/18639 0.03125 1.37051470588235 0.334236746146982 0.603820532380283 GO:0016247 channel regulator activity 5/425 168/18639 0.0297619047619048 1.30525210084034 0.337559203975423 0.603820532380283 GO:0019210 kinase inhibitor activity 3/425 90/18639 0.0333333333333333 1.46188235294118 0.337606442348229 0.603820532380283 GO:0000400 four-way junction DNA binding 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0008525 phosphatidylcholine transporter activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0015373 monoatomic anion:sodium symporter activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0030228 lipoprotein particle receptor activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0031690 adrenergic receptor binding 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0032393 MHC class I receptor activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0070064 proline-rich region binding 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0070628 proteasome binding 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0099602 neurotransmitter receptor regulator activity 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:1901611 phosphatidylglycerol binding 1/425 18/18639 0.0555555555555556 2.43647058823529 0.339905986316608 0.603820532380283 GO:0004864 protein phosphatase inhibitor activity 2/425 53/18639 0.0377358490566038 1.65496115427303 0.341393907343145 0.603820532380283 GO:0005544 calcium-dependent phospholipid binding 2/425 53/18639 0.0377358490566038 1.65496115427303 0.341393907343145 0.603820532380283 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/425 91/18639 0.032967032967033 1.44581771170006 0.343859001489639 0.606762853444421 GO:0141108 transporter regulator activity 5/425 170/18639 0.0294117647058824 1.28989619377163 0.346585348039394 0.609328356289666 GO:0003925 G protein activity 2/425 54/18639 0.037037037037037 1.6243137254902 0.349711828480582 0.609328356289666 GO:0050661 NADP binding 2/425 54/18639 0.037037037037037 1.6243137254902 0.349711828480582 0.609328356289666 GO:0051287 NAD binding 2/425 54/18639 0.037037037037037 1.6243137254902 0.349711828480582 0.609328356289666 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0034987 immunoglobulin receptor binding 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0042577 lipid phosphatase activity 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0043395 heparan sulfate proteoglycan binding 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0046624 sphingolipid transporter activity 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0140036 ubiquitin-modified protein reader activity 1/425 19/18639 0.0526315789473684 2.30823529411765 0.354971769884378 0.609328356289666 GO:0005179 hormone activity 4/425 132/18639 0.0303030303030303 1.32898395721925 0.354972001484469 0.609328356289666 GO:0051087 protein-folding chaperone binding 4/425 134/18639 0.0298507462686567 1.30914837576822 0.365342721861708 0.624684658184366 GO:0019212 phosphatase inhibitor activity 2/425 56/18639 0.0357142857142857 1.5663025210084 0.366237142567377 0.624684658184366 GO:0001972 retinoic acid binding 1/425 20/18639 0.05 2.19282352941176 0.369694487274235 0.624684658184366 GO:0016505 peptidase activator activity involved in apoptotic process 1/425 20/18639 0.05 2.19282352941176 0.369694487274235 0.624684658184366 GO:0031418 L-ascorbic acid binding 1/425 20/18639 0.05 2.19282352941176 0.369694487274235 0.624684658184366 GO:0043024 ribosomal small subunit binding 1/425 20/18639 0.05 2.19282352941176 0.369694487274235 0.624684658184366 GO:0061608 nuclear import signal receptor activity 1/425 20/18639 0.05 2.19282352941176 0.369694487274235 0.624684658184366 GO:0001846 opsonin binding 1/425 21/18639 0.0476190476190476 2.08840336134454 0.384081932513423 0.634186847013185 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/425 21/18639 0.0476190476190476 2.08840336134454 0.384081932513423 0.634186847013185 GO:0019200 carbohydrate kinase activity 1/425 21/18639 0.0476190476190476 2.08840336134454 0.384081932513423 0.634186847013185 GO:0036122 BMP binding 1/425 21/18639 0.0476190476190476 2.08840336134454 0.384081932513423 0.634186847013185 GO:0051428 peptide hormone receptor binding 1/425 21/18639 0.0476190476190476 2.08840336134454 0.384081932513423 0.634186847013185 GO:0004879 nuclear receptor activity 2/425 59/18639 0.0338983050847458 1.48666001994018 0.390710626809141 0.634186847013185 GO:0031593 polyubiquitin modification-dependent protein binding 2/425 59/18639 0.0338983050847458 1.48666001994018 0.390710626809141 0.634186847013185 GO:0070063 RNA polymerase binding 2/425 59/18639 0.0338983050847458 1.48666001994018 0.390710626809141 0.634186847013185 GO:0070851 growth factor receptor binding 4/425 139/18639 0.0287769784172662 1.26205670757512 0.391220648357438 0.634186847013185 GO:0005243 gap junction channel activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0015377 chloride:monoatomic cation symporter activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0032931 histone H3K56 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0043992 histone H3K9 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0043993 histone H3K18 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0043994 histone H3K23 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0043999 histone H2AK5 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044012 histone H2AK9 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044014 histone H2BK5 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044015 histone H2BK12 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044016 histone H3K4 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044017 histone H3K27 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0044018 histone H3K36 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0046972 histone H4K16 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0061133 endopeptidase activator activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0140908 histone H3K122 acetyltransferase activity 1/425 22/18639 0.0454545454545455 1.99347593582888 0.398141722967919 0.634186847013185 GO:0001098 basal transcription machinery binding 2/425 60/18639 0.0333333333333333 1.46188235294118 0.39877534898055 0.634186847013185 GO:0001099 basal RNA polymerase II transcription machinery binding 2/425 60/18639 0.0333333333333333 1.46188235294118 0.39877534898055 0.634186847013185 GO:0098531 ligand-modulated transcription factor activity 2/425 60/18639 0.0333333333333333 1.46188235294118 0.39877534898055 0.634186847013185 GO:0043130 ubiquitin binding 3/425 100/18639 0.03 1.31569411764706 0.399733933148146 0.634378589922738 GO:0020037 heme binding 4/425 142/18639 0.028169014084507 1.23539353769677 0.406679825750928 0.642874529126623 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/425 61/18639 0.0327868852459016 1.43791706846673 0.406790034546489 0.642874529126623 GO:0003887 DNA-directed DNA polymerase activity 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0005283 amino acid:sodium symporter activity 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0008171 O-methyltransferase activity 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0044013 histone H2B acetyltransferase activity 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0070577 lysine-acetylated histone binding 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0099186 structural constituent of postsynapse 1/425 23/18639 0.0434782608695652 1.90680306905371 0.4118813033374 0.642874529126623 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0004622 lysophospholipase activity 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0005540 hyaluronic acid binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0030215 semaphorin receptor binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0043998 histone H2A acetyltransferase activity 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0048027 mRNA 5'-UTR binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0050699 WW domain binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0070300 phosphatidic acid binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0070840 dynein complex binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0140033 acetylation-dependent protein binding 1/425 24/18639 0.0416666666666667 1.82735294117647 0.425307949560091 0.646502244612427 GO:0019001 guanyl nucleotide binding 10/425 400/18639 0.025 1.09641176470588 0.428800985483888 0.649204692022606 GO:0032561 guanyl ribonucleotide binding 10/425 400/18639 0.025 1.09641176470588 0.428800985483888 0.649204692022606 GO:0008013 beta-catenin binding 3/425 106/18639 0.0283018867924528 1.24122086570477 0.436265910839839 0.653327915119149 GO:0019902 phosphatase binding 5/425 190/18639 0.0263157894736842 1.15411764705882 0.436844315319186 0.653327915119149 GO:0004709 MAP kinase kinase kinase activity 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0008139 nuclear localization sequence binding 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0019707 protein-cysteine S-acyltransferase activity 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0042974 nuclear retinoic acid receptor binding 1/425 25/18639 0.04 1.75425882352941 0.438428772629495 0.653327915119149 GO:0008017 microtubule binding 7/425 276/18639 0.0253623188405797 1.11230179028133 0.441551185407557 0.656688108749549 GO:0008235 metalloexopeptidase activity 2/425 66/18639 0.0303030303030303 1.32898395721925 0.446049852741023 0.660728813926573 GO:0019842 vitamin binding 4/425 150/18639 0.0266666666666667 1.16950588235294 0.447472372006571 0.660728813926573 GO:0005160 transforming growth factor beta receptor binding 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0008143 poly(A) binding 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0030247 polysaccharide binding 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0030507 spectrin binding 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0070006 metalloaminopeptidase activity 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0097602 cullin family protein binding 1/425 26/18639 0.0384615384615385 1.68678733031674 0.451250722325018 0.660728813926573 GO:0008173 RNA methyltransferase activity 2/425 67/18639 0.0298507462686567 1.30914837576822 0.453727970533226 0.663073501339097 GO:0003712 transcription coregulator activity 12/425 495/18639 0.0242424242424242 1.0631871657754 0.455745150493701 0.664738109679637 GO:0046906 tetrapyrrole binding 4/425 152/18639 0.0263157894736842 1.15411764705882 0.457541275329763 0.666074510431982 GO:0005548 phospholipid transporter activity 2/425 68/18639 0.0294117647058824 1.28989619377163 0.461344895251535 0.67032262131557 GO:0008395 steroid hydroxylase activity 1/425 27/18639 0.037037037037037 1.6243137254902 0.463780590858402 0.671284717552218 GO:0015252 proton channel activity 1/425 27/18639 0.037037037037037 1.6243137254902 0.463780590858402 0.671284717552218 GO:0005506 iron ion binding 4/425 154/18639 0.025974025974026 1.13912910618793 0.467547918460606 0.675446134111983 GO:0043022 ribosome binding 3/425 112/18639 0.0267857142857143 1.1747268907563 0.471937329150894 0.680488682223288 GO:0016866 intramolecular transferase activity 1/425 28/18639 0.0357142857142857 1.5663025210084 0.476025016437876 0.683777869911712 GO:0036408 histone H3K14 acetyltransferase activity 1/425 28/18639 0.0357142857142857 1.5663025210084 0.476025016437876 0.683777869911712 GO:0016829 lyase activity 5/425 200/18639 0.025 1.09641176470588 0.48107778857919 0.687912101436075 GO:0003785 actin monomer binding 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0004181 metallocarboxypeptidase activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0004629 phospholipase C activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0005416 amino acid:monoatomic cation symporter activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0010484 histone H3 acetyltransferase activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0016417 S-acyltransferase activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0097472 cyclin-dependent protein kinase activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0099604 ligand-gated calcium channel activity 1/425 29/18639 0.0344827586206897 1.51229208924949 0.487990486751879 0.687912101436075 GO:0101005 deubiquitinase activity 3/425 115/18639 0.0260869565217391 1.14408184143223 0.489387447154535 0.688599065977664 GO:0005525 GTP binding 9/425 378/18639 0.0238095238095238 1.04420168067227 0.495017176234313 0.688998707062351 GO:0099106 ion channel regulator activity 4/425 160/18639 0.025 1.09641176470588 0.497146827409078 0.688998707062351 GO:0043539 protein serine/threonine kinase activator activity 2/425 73/18639 0.0273972602739726 1.20154713940371 0.49847240265985 0.688998707062351 GO:0001965 G-protein alpha-subunit binding 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0016769 transferase activity, transferring nitrogenous groups 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0043995 histone H4K5 acetyltransferase activity 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0043996 histone H4K8 acetyltransferase activity 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0043997 histone H4K12 acetyltransferase activity 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0051721 protein phosphatase 2A binding 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0098918 structural constituent of synapse 1/425 30/18639 0.0333333333333333 1.46188235294118 0.499683342374149 0.688998707062351 GO:0140097 catalytic activity, acting on DNA 8/425 336/18639 0.0238095238095238 1.04420168067227 0.500812142066741 0.689299620990041 GO:0048029 monosaccharide binding 2/425 74/18639 0.027027027027027 1.18531001589825 0.505699774952383 0.694763574662348 GO:0017147 Wnt-protein binding 1/425 31/18639 0.032258064516129 1.41472485768501 0.511109780091973 0.700924100597144 GO:0015631 tubulin binding 9/425 385/18639 0.0233766233766234 1.02521619556914 0.517130437199571 0.705920053373744 GO:0032182 ubiquitin-like protein binding 3/425 120/18639 0.025 1.09641176470588 0.517827478209952 0.705920053373744 GO:0004518 nuclease activity 5/425 209/18639 0.0239234449760766 1.04919786096257 0.519844834354161 0.705920053373744 GO:0031369 translation initiation factor binding 1/425 32/18639 0.03125 1.37051470588235 0.522275856159305 0.705920053373744 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/425 32/18639 0.03125 1.37051470588235 0.522275856159305 0.705920053373744 GO:0070717 poly-purine tract binding 1/425 32/18639 0.03125 1.37051470588235 0.522275856159305 0.705920053373744 GO:0140142 nucleocytoplasmic carrier activity 1/425 32/18639 0.03125 1.37051470588235 0.522275856159305 0.705920053373744 GO:0004540 RNA nuclease activity 3/425 121/18639 0.0247933884297521 1.08735051045211 0.523412987361829 0.705920053373744 GO:0015108 chloride transmembrane transporter activity 3/425 121/18639 0.0247933884297521 1.08735051045211 0.523412987361829 0.705920053373744 GO:0008094 ATP-dependent activity, acting on DNA 5/425 210/18639 0.0238095238095238 1.04420168067227 0.524078031698869 0.705920053373744 GO:0003724 RNA helicase activity 2/425 77/18639 0.025974025974026 1.13912910618793 0.526971744527422 0.708557034826391 GO:0019956 chemokine binding 1/425 33/18639 0.0303030303030303 1.32898395721925 0.533187489476459 0.715643492080993 GO:0008186 ATP-dependent activity, acting on RNA 2/425 79/18639 0.0253164556962025 1.11029039463887 0.540805414010882 0.721775110281077 GO:0016835 carbon-oxygen lyase activity 2/425 79/18639 0.0253164556962025 1.11029039463887 0.540805414010882 0.721775110281077 GO:0015020 glucuronosyltransferase activity 1/425 34/18639 0.0294117647058824 1.28989619377163 0.543850464698028 0.721775110281077 GO:0019825 oxygen binding 1/425 34/18639 0.0294117647058824 1.28989619377163 0.543850464698028 0.721775110281077 GO:0030332 cyclin binding 1/425 34/18639 0.0294117647058824 1.28989619377163 0.543850464698028 0.721775110281077 GO:0005154 epidermal growth factor receptor binding 1/425 35/18639 0.0285714285714286 1.25304201680672 0.554270435270634 0.721775110281077 GO:0005343 organic acid:sodium symporter activity 1/425 35/18639 0.0285714285714286 1.25304201680672 0.554270435270634 0.721775110281077 GO:0016229 steroid dehydrogenase activity 1/425 35/18639 0.0285714285714286 1.25304201680672 0.554270435270634 0.721775110281077 GO:0061631 ubiquitin conjugating enzyme activity 1/425 35/18639 0.0285714285714286 1.25304201680672 0.554270435270634 0.721775110281077 GO:0033192 calmodulin-dependent protein phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0140791 histone H2AXS140 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/425 81/18639 0.0246913580246914 1.08287581699346 0.55435664034435 0.721775110281077 GO:0019783 ubiquitin-like protein peptidase activity 3/425 127/18639 0.0236220472440945 1.03597962019453 0.556161451253757 0.721775110281077 GO:0140030 modification-dependent protein binding 4/425 173/18639 0.023121387283237 1.01402244134648 0.558670341173884 0.721775110281077 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/425 82/18639 0.024390243902439 1.0696700143472 0.561025460125539 0.721775110281077 GO:0033549 MAP kinase phosphatase activity 2/425 82/18639 0.024390243902439 1.0696700143472 0.561025460125539 0.721775110281077 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 3/425 128/18639 0.0234375 1.02788602941176 0.561487644176319 0.721775110281077 GO:0000993 RNA polymerase II complex binding 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0004190 aspartic-type endopeptidase activity 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0016409 palmitoyltransferase activity 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/425 36/18639 0.0277777777777778 1.21823529411765 0.56445292640211 0.721775110281077 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/425 83/18639 0.0240963855421687 1.0567824238129 0.567622721009948 0.723384511455439 GO:0005254 chloride channel activity 2/425 83/18639 0.0240963855421687 1.0567824238129 0.567622721009948 0.723384511455439 GO:0004527 exonuclease activity 2/425 84/18639 0.0238095238095238 1.04420168067227 0.57414821202476 0.725915403737019 GO:0017018 myosin phosphatase activity 2/425 84/18639 0.0238095238095238 1.04420168067227 0.57414821202476 0.725915403737019 GO:0022829 wide pore channel activity 1/425 37/18639 0.027027027027027 1.18531001589825 0.574403337963638 0.725915403737019 GO:0030280 structural constituent of skin epidermis 1/425 37/18639 0.027027027027027 1.18531001589825 0.574403337963638 0.725915403737019 GO:0070001 aspartic-type peptidase activity 1/425 37/18639 0.027027027027027 1.18531001589825 0.574403337963638 0.725915403737019 GO:0043021 ribonucleoprotein complex binding 4/425 177/18639 0.0225988700564972 0.99110667996012 0.576772462208401 0.727694589819599 GO:0000146 microfilament motor activity 1/425 38/18639 0.0263157894736842 1.15411764705882 0.584126947326365 0.730882808472824 GO:0005109 frizzled binding 1/425 38/18639 0.0263157894736842 1.15411764705882 0.584126947326365 0.730882808472824 GO:0042162 telomeric DNA binding 1/425 38/18639 0.0263157894736842 1.15411764705882 0.584126947326365 0.730882808472824 GO:0042887 amide transmembrane transporter activity 1/425 38/18639 0.0263157894736842 1.15411764705882 0.584126947326365 0.730882808472824 GO:0043531 ADP binding 1/425 38/18639 0.0263157894736842 1.15411764705882 0.584126947326365 0.730882808472824 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/425 86/18639 0.0232558139534884 1.01991792065663 0.586983272024854 0.733244780400683 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/425 39/18639 0.0256410256410256 1.12452488687783 0.593628912133972 0.740324689432318 GO:0030331 nuclear estrogen receptor binding 1/425 40/18639 0.025 1.09641176470588 0.602914273012632 0.746982168036927 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/425 40/18639 0.025 1.09641176470588 0.602914273012632 0.746982168036927 GO:0071855 neuropeptide receptor binding 1/425 40/18639 0.025 1.09641176470588 0.602914273012632 0.746982168036927 GO:0071949 FAD binding 1/425 40/18639 0.025 1.09641176470588 0.602914273012632 0.746982168036927 GO:1901981 phosphatidylinositol phosphate binding 4/425 185/18639 0.0216216216216216 0.948248012718601 0.611678456569431 0.748424689593487 GO:0001530 lipopolysaccharide binding 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0008227 G protein-coupled amine receptor activity 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0017080 sodium channel regulator activity 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0140318 protein transporter activity 1/425 41/18639 0.024390243902439 1.0696700143472 0.611987956219773 0.748424689593487 GO:0016887 ATP hydrolysis activity 9/425 417/18639 0.0215827338129496 0.946542530681337 0.613433638526953 0.748982684459521 GO:0016859 cis-trans isomerase activity 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0031492 nucleosomal DNA binding 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0035198 miRNA binding 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0043175 RNA polymerase core enzyme binding 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0048487 beta-tubulin binding 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0051879 Hsp90 protein binding 1/425 42/18639 0.0238095238095238 1.04420168067227 0.620854776233033 0.750778060077326 GO:0008375 acetylglucosaminyltransferase activity 1/425 43/18639 0.0232558139534884 1.01991792065663 0.629519438280726 0.760041809854083 GO:0001046 core promoter sequence-specific DNA binding 1/425 44/18639 0.0227272727272727 0.996737967914438 0.637986540815179 0.767815280440526 GO:0043014 alpha-tubulin binding 1/425 44/18639 0.0227272727272727 0.996737967914438 0.637986540815179 0.767815280440526 GO:0008194 UDP-glycosyltransferase activity 3/425 145/18639 0.0206896551724138 0.907375253549696 0.645858128256715 0.776054925540211 GO:0043495 protein-membrane adaptor activity 1/425 47/18639 0.0212765957446809 0.933116395494368 0.662246924608142 0.791976179981617 GO:0061749 forked DNA-dependent helicase activity 1/425 47/18639 0.0212765957446809 0.933116395494368 0.662246924608142 0.791976179981617 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/425 47/18639 0.0212765957446809 0.933116395494368 0.662246924608142 0.791976179981617 GO:0008509 monoatomic anion transmembrane transporter activity 3/425 149/18639 0.0201342281879195 0.883016186340308 0.663955010535389 0.792446195664851 GO:0042393 histone binding 5/425 247/18639 0.0202429149797571 0.887782805429864 0.667133565305928 0.792446195664851 GO:0009378 four-way junction helicase activity 1/425 48/18639 0.0208333333333333 0.913676470588235 0.669967721566056 0.792446195664851 GO:0036121 double-stranded DNA helicase activity 1/425 48/18639 0.0208333333333333 0.913676470588235 0.669967721566056 0.792446195664851 GO:0038187 pattern recognition receptor activity 1/425 48/18639 0.0208333333333333 0.913676470588235 0.669967721566056 0.792446195664851 GO:0043138 3'-5' DNA helicase activity 1/425 48/18639 0.0208333333333333 0.913676470588235 0.669967721566056 0.792446195664851 GO:0140693 molecular condensate scaffold activity 1/425 48/18639 0.0208333333333333 0.913676470588235 0.669967721566056 0.792446195664851 GO:0015171 amino acid transmembrane transporter activity 2/425 102/18639 0.0196078431372549 0.859930795847751 0.679335879239319 0.802273417447995 GO:0004722 protein serine/threonine phosphatase activity 2/425 103/18639 0.0194174757281553 0.851581953169617 0.684508994125226 0.805868287018345 GO:0005253 monoatomic anion channel activity 2/425 103/18639 0.0194174757281553 0.851581953169617 0.684508994125226 0.805868287018345 GO:0003714 transcription corepressor activity 4/425 204/18639 0.0196078431372549 0.859930795847751 0.687121222757014 0.807687524265621 GO:0004386 helicase activity 3/425 155/18639 0.0193548387096774 0.848834914611006 0.689826113269274 0.80960987247262 GO:0005048 signal sequence binding 1/425 51/18639 0.0196078431372549 0.859930795847751 0.692089531263509 0.809755448479871 GO:0016830 carbon-carbon lyase activity 1/425 51/18639 0.0196078431372549 0.859930795847751 0.692089531263509 0.809755448479871 GO:0005246 calcium channel regulator activity 1/425 53/18639 0.0188679245283019 0.827480577136515 0.706009195693126 0.823496088042675 GO:0051018 protein kinase A binding 1/425 53/18639 0.0188679245283019 0.827480577136515 0.706009195693126 0.823496088042675 GO:0004843 cysteine-type deubiquitinase activity 2/425 108/18639 0.0185185185185185 0.812156862745098 0.709355919386402 0.826126816885394 GO:0017069 snRNA binding 1/425 54/18639 0.0185185185185185 0.812156862745098 0.712731787527325 0.826244966551585 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/425 54/18639 0.0185185185185185 0.812156862745098 0.712731787527325 0.826244966551585 GO:0140463 chromatin-protein adaptor activity 1/425 54/18639 0.0185185185185185 0.812156862745098 0.712731787527325 0.826244966551585 GO:0004620 phospholipase activity 2/425 109/18639 0.018348623853211 0.804705882352941 0.714124769757323 0.826593961324607 GO:1902936 phosphatidylinositol bisphosphate binding 2/425 111/18639 0.018018018018018 0.790206677265501 0.723465836145709 0.836127691545499 GO:0015103 inorganic anion transmembrane transporter activity 3/425 165/18639 0.0181818181818182 0.797390374331551 0.729573475285014 0.841901098766396 GO:0008408 3'-5' exonuclease activity 1/425 58/18639 0.0172413793103448 0.756146044624746 0.738122970940775 0.847889361156551 GO:0017116 single-stranded DNA helicase activity 1/425 58/18639 0.0172413793103448 0.756146044624746 0.738122970940775 0.847889361156551 GO:0061980 regulatory RNA binding 1/425 58/18639 0.0172413793103448 0.756146044624746 0.738122970940775 0.847889361156551 GO:0015459 potassium channel regulator activity 1/425 59/18639 0.0169491525423729 0.74333000997009 0.744112838943045 0.852183689984697 GO:0070888 E-box binding 1/425 59/18639 0.0169491525423729 0.74333000997009 0.744112838943045 0.852183689984697 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/425 60/18639 0.0166666666666667 0.730941176470588 0.749966016739019 0.857589538778607 GO:0015026 coreceptor activity 1/425 61/18639 0.0163934426229508 0.718958534233366 0.755685616442228 0.861527125974046 GO:0016836 hydro-lyase activity 1/425 61/18639 0.0163934426229508 0.718958534233366 0.755685616442228 0.861527125974046 GO:0015179 L-amino acid transmembrane transporter activity 1/425 62/18639 0.0161290322580645 0.707362428842505 0.761274679474419 0.866593883251332 GO:0003697 single-stranded DNA binding 2/425 121/18639 0.0165289256198347 0.72490034030141 0.76637780860853 0.870193833392623 GO:1901682 sulfur compound transmembrane transporter activity 1/425 63/18639 0.0158730158730159 0.696134453781513 0.766736178167609 0.870193833392623 GO:0003924 GTPase activity 6/425 331/18639 0.0181268882175227 0.794981339968011 0.769307610232066 0.870363261656566 GO:0008528 G protein-coupled peptide receptor activity 2/425 122/18639 0.0163934426229508 0.718958534233366 0.770334722998546 0.870363261656566 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/425 122/18639 0.0163934426229508 0.718958534233366 0.770334722998546 0.870363261656566 GO:0140098 catalytic activity, acting on RNA 7/425 387/18639 0.0180878552971576 0.793269493844049 0.782722483466236 0.883041609514069 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/425 67/18639 0.0149253731343284 0.654574187884109 0.787363644751238 0.886955772435547 GO:0030145 manganese ion binding 1/425 68/18639 0.0147058823529412 0.644948096885813 0.792229596236309 0.890508455664915 GO:0001653 peptide receptor activity 2/425 128/18639 0.015625 0.685257352941177 0.792870144145512 0.890508455664915 GO:0002039 p53 binding 1/425 69/18639 0.0144927536231884 0.635601023017903 0.796984451742182 0.893803303657528 GO:0016298 lipase activity 2/425 130/18639 0.0153846153846154 0.674714932126697 0.799937063661075 0.895679118398031 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/425 70/18639 0.0142857142857143 0.626521008403361 0.801630741888093 0.895679118398031 GO:0005262 calcium channel activity 2/425 131/18639 0.0152671755725191 0.669564436461608 0.803389856528749 0.895679118398031 GO:0031072 heat shock protein binding 2/425 131/18639 0.0152671755725191 0.669564436461608 0.803389856528749 0.895679118398031 GO:0140299 molecular sensor activity 1/425 71/18639 0.0140845070422535 0.617696768848384 0.806170939782302 0.896827891951958 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/425 132/18639 0.0151515151515152 0.664491978609626 0.80678968879694 0.896827891951958 GO:0003678 DNA helicase activity 1/425 74/18639 0.0135135135135135 0.592655007949126 0.819178875550225 0.90341026296966 GO:0031491 nucleosome binding 1/425 74/18639 0.0135135135135135 0.592655007949126 0.819178875550225 0.90341026296966 GO:0035064 methylated histone binding 1/425 74/18639 0.0135135135135135 0.592655007949126 0.819178875550225 0.90341026296966 GO:0016779 nucleotidyltransferase activity 2/425 136/18639 0.0147058823529412 0.644948096885813 0.819871665337063 0.90341026296966 GO:0044325 transmembrane transporter binding 2/425 136/18639 0.0147058823529412 0.644948096885813 0.819871665337063 0.90341026296966 GO:0140789 histone phosphatase activity 2/425 136/18639 0.0147058823529412 0.644948096885813 0.819871665337063 0.90341026296966 GO:0140034 methylation-dependent protein binding 1/425 76/18639 0.0131578947368421 0.577058823529412 0.827363240344898 0.910340076949255 GO:0016758 hexosyltransferase activity 3/425 197/18639 0.0152284263959391 0.667865034338609 0.830227969685566 0.912037725130749 GO:0051540 metal cluster binding 1/425 77/18639 0.012987012987013 0.569564553093965 0.831315760026707 0.912037725130749 GO:0015370 solute:sodium symporter activity 1/425 79/18639 0.0126582278481013 0.555145197319434 0.838952002252932 0.919083452540477 GO:0015101 organic cation transmembrane transporter activity 1/425 81/18639 0.0123456790123457 0.541437908496732 0.846243332559684 0.925731506860811 GO:0015085 calcium ion transmembrane transporter activity 2/425 147/18639 0.0136054421768707 0.596686674669868 0.851846210363808 0.930515990253106 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 4/425 268/18639 0.0149253731343284 0.654574187884109 0.863307885524119 0.941677333345473 GO:0008081 phosphoric diester hydrolase activity 1/425 87/18639 0.0114942528735632 0.504097363083164 0.866199826883996 0.943472329426165 GO:0052689 carboxylic ester hydrolase activity 1/425 92/18639 0.0108695652173913 0.476700767263427 0.880840909016118 0.957160586158059 GO:0001217 DNA-binding transcription repressor activity 4/425 278/18639 0.0143884892086331 0.631028353787558 0.881295810504844 0.957160586158059 GO:0051213 dioxygenase activity 1/425 93/18639 0.010752688172043 0.47157495256167 0.883571410642697 0.958257246212781 GO:0030527 structural constituent of chromatin 1/425 98/18639 0.0102040816326531 0.447515006002401 0.896315540714039 0.968716748378407 GO:0042626 ATPase-coupled transmembrane transporter activity 1/425 98/18639 0.0102040816326531 0.447515006002401 0.896315540714039 0.968716748378407 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/425 167/18639 0.0119760479041916 0.525227192673477 0.897054743214351 0.968716748378407 GO:0005085 guanyl-nucleotide exchange factor activity 3/425 230/18639 0.0130434782608696 0.572040920716113 0.898612430622157 0.969016538434434 GO:0004721 phosphoprotein phosphatase activity 2/425 175/18639 0.0114285714285714 0.501216806722689 0.911253259149818 0.978504991145955 GO:0045182 translation regulator activity 5/425 356/18639 0.0140449438202247 0.615961665565102 0.911538902805539 0.978504991145955 GO:0140996 histone H3 kinase activity 5/425 357/18639 0.0140056022408964 0.614236282748394 0.912739393669552 0.978504991145955 GO:0000149 SNARE binding 1/425 106/18639 0.00943396226415094 0.413740288568258 0.913874542589419 0.978504991145955 GO:0004497 monooxygenase activity 1/425 106/18639 0.00943396226415094 0.413740288568258 0.913874542589419 0.978504991145955 GO:0035173 histone kinase activity 5/425 360/18639 0.0138888888888889 0.609117647058824 0.916255660102886 0.979668834319046 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2/425 181/18639 0.0110497237569061 0.484601884952876 0.920676433241644 0.98300713676153 GO:0046943 carboxylic acid transmembrane transporter activity 2/425 188/18639 0.0106382978723404 0.466558197747184 0.930480138605314 0.989483071038105 GO:0015294 solute:monoatomic cation symporter activity 1/425 116/18639 0.00862068965517241 0.378073022312373 0.931710429065337 0.989483071038105 GO:0005342 organic acid transmembrane transporter activity 2/425 189/18639 0.0105820105820106 0.464089635854342 0.931783603006096 0.989483071038105 GO:0004674 protein serine/threonine kinase activity 6/425 433/18639 0.0138568129330254 0.607710908843907 0.932452070523159 0.989483071038105 GO:1990782 protein tyrosine kinase binding 1/425 117/18639 0.00854700854700855 0.374841628959276 0.933277295536601 0.989483071038105 GO:0016755 aminoacyltransferase activity 7/425 496/18639 0.0141129032258065 0.618942125237192 0.937884367528641 0.992976875831023 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/425 122/18639 0.00819672131147541 0.359479267116683 0.940589710810413 0.99399419186619 GO:0016757 glycosyltransferase activity 3/425 267/18639 0.0112359550561798 0.492769332452082 0.945015451797971 0.99399419186619 GO:0004842 ubiquitin-protein transferase activity 6/425 449/18639 0.0133630289532294 0.586055286257042 0.945480194973851 0.99399419186619 GO:0008514 organic anion transmembrane transporter activity 3/425 269/18639 0.0111524163568773 0.489105619943145 0.946850981529998 0.99399419186619 GO:0042826 histone deacetylase binding 1/425 127/18639 0.0078740157480315 0.345326540064845 0.947102406064835 0.99399419186619 GO:0008168 methyltransferase activity 2/425 204/18639 0.00980392156862745 0.429965397923875 0.948762364312536 0.99399419186619 GO:0035591 signaling adaptor activity 1/425 129/18639 0.00775193798449612 0.339972640218878 0.949503443763094 0.99399419186619 GO:0016791 phosphatase activity 3/425 273/18639 0.010989010989011 0.481939237233355 0.950352567016086 0.99399419186619 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1/425 130/18639 0.00769230769230769 0.337357466063348 0.950662873066211 0.99399419186619 GO:0015297 antiporter activity 1/425 135/18639 0.00740740740740741 0.324862745098039 0.956073555204958 0.994162960397032 GO:0099094 ligand-gated monoatomic cation channel activity 1/425 136/18639 0.00735294117647059 0.322474048442907 0.957082458092868 0.994162960397032 GO:0031267 small GTPase binding 3/425 283/18639 0.0106007067137809 0.464909582207441 0.958188933637135 0.994162960397032 GO:0016741 transferase activity, transferring one-carbon groups 2/425 215/18639 0.00930232558139535 0.407967168262654 0.958568958249605 0.994162960397032 GO:0140101 catalytic activity, acting on a tRNA 1/425 139/18639 0.00719424460431655 0.315514176893779 0.959972553656104 0.994162960397032 GO:0140767 enzyme-substrate adaptor activity 1/425 139/18639 0.00719424460431655 0.315514176893779 0.959972553656104 0.994162960397032 GO:0061630 ubiquitin protein ligase activity 4/425 353/18639 0.0113314447592068 0.496957173804366 0.961889613529292 0.994162960397032 GO:0141003 histone H2AX kinase activity 4/425 354/18639 0.0112994350282486 0.49555333998006 0.962492985942589 0.994162960397032 GO:0019787 ubiquitin-like protein transferase activity 6/425 479/18639 0.0125260960334029 0.549350362274346 0.964001558013298 0.994162960397032 GO:0015293 symporter activity 1/425 146/18639 0.00684931506849315 0.300386784850927 0.965983288035682 0.994162960397032 GO:0106310 protein serine kinase activity 4/425 361/18639 0.0110803324099723 0.48594427244582 0.966475043847963 0.994162960397032 GO:0042578 phosphoric ester hydrolase activity 4/425 363/18639 0.0110192837465565 0.483266893534273 0.967538472301367 0.994162960397032 GO:0030695 GTPase regulator activity 6/425 489/18639 0.0122699386503067 0.538116203536629 0.968767056371664 0.994162960397032 GO:0060589 nucleoside-triphosphatase regulator activity 6/425 490/18639 0.0122448979591837 0.537018007202881 0.969210389396314 0.994162960397032 GO:0003774 cytoskeletal motor activity 1/425 153/18639 0.0065359477124183 0.286643598615917 0.971093220144743 0.994275176908269 GO:0061659 ubiquitin-like protein ligase activity 4/425 372/18639 0.010752688172043 0.47157495256167 0.971946672274926 0.994275176908269 GO:0051020 GTPase binding 3/425 315/18639 0.00952380952380952 0.417680672268908 0.976167935096561 0.996041018271261 GO:0005216 monoatomic ion channel activity 5/425 448/18639 0.0111607142857143 0.489469537815126 0.976931364763843 0.996041018271261 GO:0015081 sodium ion transmembrane transporter activity 1/425 164/18639 0.00609756097560976 0.267417503586801 0.977620180416838 0.996041018271261 GO:0016874 ligase activity 1/425 167/18639 0.00598802395209581 0.262613596336738 0.97912948345408 0.996237928729488 GO:0005261 monoatomic cation channel activity 3/425 341/18639 0.00879765395894428 0.385834052095912 0.985092193139721 0.999080462754791 GO:0005096 GTPase activator activity 2/425 271/18639 0.00738007380073801 0.323663989581072 0.986336829573558 0.999080462754791 GO:0015276 ligand-gated monoatomic ion channel activity 1/425 186/18639 0.00537634408602151 0.235787476280835 0.986591835615671 0.999080462754791 GO:0022834 ligand-gated channel activity 1/425 188/18639 0.00531914893617021 0.233279098873592 0.98720235949879 0.999080462754791 GO:0015291 secondary active transmembrane transporter activity 2/425 287/18639 0.00696864111498258 0.305620004099201 0.990119256544791 0.999527254055639 GO:0046873 metal ion transmembrane transporter activity 4/425 450/18639 0.00888888888888889 0.389835294117647 0.992501660167668 0.999527254055639 GO:0000287 magnesium ion binding 1/425 230/18639 0.00434782608695652 0.190680306905371 0.995196159283448 0.999527254055639 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 4/425 484/18639 0.00826446280991736 0.362450170150705 0.995890977954823 0.999527254055639 GO:0001216 DNA-binding transcription activator activity 4/425 491/18639 0.00814663951120163 0.35728285611597 0.996375845159653 0.999527254055639 GO:0035402 histone H3T11 kinase activity 1/425 247/18639 0.00404858299595142 0.177556561085973 0.996771012485665 0.999527254055639 GO:0003730 mRNA 3'-UTR binding 1/425 262/18639 0.00381679389312977 0.167391109115402 0.997726437858176 0.999527254055639 GO:0022836 gated channel activity 1/425 318/18639 0.00314465408805031 0.137913429522753 0.999387954053841 0.999527254055639 GO:0030371 translation repressor activity 1/425 329/18639 0.00303951367781155 0.133302342213481 0.999527254055639 0.999527254055639