category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/897	308/9376	2.47740665131969	MT-CO2/MT-CYB/MT-CO3/MT-ND3/TGM2/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/DCTN2/COX7A1/MT-CO1/NDUFA5/DCTN4/POLR2G/PSMD14/PSMB7/HDAC2/WIPI1/NDUFC1/AP2A1/PSMC1/PSMD3/PSMC5/POLR2E/ADRM1/PSMB6/MT-ND5/MT-ATP8/PSMD1/CREB3/AP2M1/NDUFA3/NDUFS2/CREBBP/SDHC/CREB1/DCTN5/GPX3/ATG2A/SP1/ATG14/RB1CC1/MT-ND4L/WIPI2/ACTR1A/PSMD7/NDUFS1/NDUFV1/KLC1/NDUFB7/NDUFS6/ATG13/CLTA/MAP2K7/AP2B1/PSMB4/CREB3L2/AP2S1/TUBB6/TUBB4B/UQCRC1/NDUFA1/NDUFB1/HIP1/MT-ND6/PPIF/POLR2I/NDUFS7/AMBRA1/TUBA3E/TUBA1C/PSMB5	8.57490257624032
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	61/897	275/9376	2.31858112901591	MT-CO2/MT-CYB/C1QB/MT-CO3/C1QA/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/C1QC/COX7A1/MT-CO1/NDUFA5/CAV1/PSMD14/PSMB7/NDUFC1/PSMC1/PSMD3/PPP3CB/PSMC5/ADRM1/PSMB6/MT-ND5/MT-ATP8/PSMD1/CREB3/NDUFA3/EGR1/NDUFS2/PRNP/SDHC/CREB1/MAPK14/CYBA/MT-ND4L/PSMD7/NDUFS1/NDUFV1/KLC1/PRKACA/NDUFB7/NDUFS6/TNF/PSMB4/CREB3L2/TUBB6/TUBB4B/CAV2/UQCRC1/NDUFA1/NDUFB1/MT-ND6/PPIF/NDUFS7/ITPR3/MAPK3/TUBA3E/TUBA1C/PSMB5	7.21835418394286
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	56/897	250/9376	2.34138684503902	PSAP/CTSL/CTSB/CD68/HEXB/LAMTOR5/GGA1/ATP6V1E1/RAB7A/AP2A1/VPS35/BORCS5/AP3D1/ATP6V0D1/KXD1/AP2M1/SNAP29/AP1G2/AP1S2/HEXA/ASAH1/CLN8/NPC2/SCARB2/LAMTOR1/ATP6V0A2/VPS16/CLTA/OSBPL2/AP2B1/AP2S1/GALNS/ARSG/AP5Z1/CTSH/AP1M1/PPT1/GGA3/ATP6V1B2/CTSS/BORCS8/ATP6V0B/VPS18/RRAGA/ACP5/CTSZ/MLST8/LGMN/RRAGC/LAMTOR4/NPC1/ATP6AP1/OSBPL1A/BORCS7/AP4E1/ARSA	6.99187019736276
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	75/897	388/9376	2.0204806399338	MT-CO2/MT-CYB/MT-CO3/MT-ND3/APOE/MT-ND1/MT-ATP6/DKK1/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/PSMD14/PSMB7/WIPI1/APH1A/NDUFC1/AKT2/PSMC1/PSMD3/PPP3CB/PSMC5/ADRM1/PSMB6/MT-ND5/MT-ATP8/WNT5A/PSMD1/SLC39A4/NDUFA3/NDUFS2/WNT4/SDHC/SLC39A7/ATG2A/ATG14/RB1CC1/MT-ND4L/WIPI2/PSMD7/NDUFS1/NDUFV1/KLC1/NDUFB7/NDUFS6/ATG13/TNF/AXIN1/MAP2K7/PSMB4/TUBB6/TUBB4B/APH1B/CSNK1E/INSR/IRS2/NCSTN/UQCRC1/NDUFA1/NDUFB1/SLC39A3/MT-ND6/DVL3/PPIF/SLC39A6/NDUFS7/ITPR3/SLC39A1/MAPK3/AMBRA1/GAPDH/TUBA3E/TUBA1C/PSMB5	6.67726546951223
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	58/897	268/9376	2.26213414532688	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/PSMD14/PSMB7/NDUFC1/PSMC1/PSMD3/PSMC5/UBE2G2/ADRM1/PSMB6/MT-ND5/MT-ATP8/PSMD1/SLC39A4/NDUFA3/NDUFS2/SDHC/MAOA/SLC39A7/DAXX/MT-ND4L/KEAP1/PSMD7/NDUFS1/NDUFV1/KLC1/PRKACA/NDUFB7/NDUFS6/PSMB4/UBA52/TUBB6/TUBB4B/NFE2L2/UQCRC1/NDUFA1/NDUFB1/SLC39A3/MT-ND6/PPIF/SLC39A6/NDUFS7/ITPR3/MFN2/SLC39A1/TUBA3E/TUBA1C/PSMB5	6.81821896383308
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	68/897	368/9376	1.93146236246425	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/DCTN2/COX7A1/MT-CO1/NDUFA5/DCTN4/RAB1A/PSMD14/PSMB7/WIPI1/NDUFC1/PSMC1/PSMD3/PPP3CB/PSMC5/ADRM1/PSMB6/MT-ND5/MT-ATP8/PSMD1/NDUFA3/NDUFS2/SDHC/MAPK14/DCTN5/GPX3/ATG2A/ATG14/DAXX/RB1CC1/MT-ND4L/WIPI2/VAPB/ACTR1A/PSMD7/NDUFS1/NDUFV1/KLC1/NDUFB7/NDUFS6/ATG13/TNF/TPR/PSMB4/TUBB6/POM121/TUBB4B/SIGMAR1/NUP62/UQCRC1/NDUFA1/NDUFB1/MT-ND6/NDUFS7/ITPR3/AMBRA1/ANXA11/NEFH/TUBA3E/TUBA1C/PSMB5	5.92904264099177
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	33/897	138/9376	2.49953952789492	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/ATP6V1E1/NDUFC1/MT-ND5/MT-ATP8/ATP6V0D1/NDUFA3/NDUFS2/SDHC/MT-ND4L/NDUFS1/NDUFV1/NDUFB7/ATP6V0A2/NDUFS6/ATP6V1B2/ATP6V0B/UQCRC1/NDUFA1/NDUFB1/MT-ND6/NDUFS7/ATP6AP1	5.7718897185938
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	79/897	480/9376	1.72032701597919	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/DKK1/MT-ND2/MT-ND4/DCTN2/COX7A1/MT-CO1/NDUFA5/DCTN4/RAB1A/PSMD14/PSMB7/WIPI1/NDUFC1/PSMC1/PSMD3/PPP3CB/PSMC5/UBE2G2/ADRM1/PSMB6/MT-ND5/MT-ATP8/WNT5A/PSMD1/NDUFA3/NDUFS2/PRNP/WNT4/SDHC/MAPK14/DCTN5/ZFYVE1/GPX3/ATG2A/ATG14/DAXX/RB1CC1/MT-ND4L/WIPI2/VAPB/ACTR1A/PSMD7/NDUFS1/NDUFV1/KLC1/NDUFB7/NDUFS6/ATG13/TNF/AXIN1/MAP2K7/PSMB4/UBA52/TUBB6/TUBB4B/CSNK1E/SIGMAR1/UQCRC1/NDUFA1/NDUFB1/HIP1/MT-ND6/DVL3/PPIF/NDUFS7/ITPR3/MFN2/MAPK3/AMBRA1/NEFH/TUBA3E/TUBA1C/PSMB5	5.26941589358123
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/897	155/9376	2.29283273995756	HLA-DRA/CTSL/HLA-DRB1/HLA-DRB5/CD14/DYNC1LI1/ATP6V1E1/RAB7A/C1R/SEC61A1/ATP6V0D1/HLA-G/HLA-DQA1/RAB5C/FCGR3A/CYBA/HLA-DPA1/HLA-DPB1/DYNC1H1/EEA1/ATP6V0A2/VAMP3/TUBB6/TUBB4B/MRC1/ATP6V1B2/CTSS/ATP6V0B/TFRC/DYNC2H1/CANX/ATP6AP1/TUBA3E/TUBA1C	5.27872116241626
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/897	227/9376	2.02605847195006	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/EGFR/NDUFC1/AKT2/PRKD2/MT-ND5/MT-ATP8/JUN/NDUFA3/NDUFS2/SDHC/MAPK14/PTPN1/CYBA/MT-ND4L/KEAP1/NFKBIA/NDUFS1/NDUFV1/NDUFB7/NDUFS6/MAP2K7/GSTO1/MGST3/NFE2L2/FOXO3/PLD1/UQCRC1/NDUFA1/NDUFB1/MT-ND6/PPIF/NDUFS7/MAPK3	5.08988262577336
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/897	205/9376	2.03953557930228	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/G6PD/MMP2/NDUFC1/AKT2/MT-ND5/MT-ATP8/NDUFA3/NDUFS2/SDHC/MAPK14/CYBA/TBC1D4/SP1/MT-ND4L/NDUFS1/NDUFV1/TGFBR1/NDUFB7/NDUFS6/INSR/UQCRC1/NDUFA1/COL1A1/NDUFB1/MT-ND6/PPIF/NDUFS7/GAPDH/PPP1CA	4.89460313515324
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	43/897	235/9376	1.91260703527123	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-ND1/MT-ATP6/MT-ND2/MT-ND4/COX7A1/MT-CO1/NDUFA5/NDUFC1/MGLL/SMARCD2/COX16/MT-ND5/MT-ATP8/CREB3/NDUFA3/NDUFS2/SDHC/CREB1/MAPK14/MT-ND4L/PRKAG2/TSC2/NDUFS1/NDUFV1/PRKACA/NDUFB7/SMARCA4/NDUFS6/FRS2/CREB3L2/CNR1/UQCRC1/NDUFA1/NDUFB1/MT-ND6/NDUFS7/ACSL1/RPS6KA2/MLST8	4.60819057317751
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/897	44/9376	3.32583358670315	DCTN2/DCTN4/DYNC1LI1/RAB11A/DYNLL2/CREB3/CREB1/RAB5C/DCTN5/DYNC1H1/PRKACA/CREB3L2/DYNC2H1/DYNC2LI1	5.02952710550891
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	33/897	169/9376	2.04104411153549	CTSL/CTSB/GABARAP/RAB1A/WDR45B/WIPI1/RAB7A/AKT2/SNAP29/ATG10/RUBCN/UVRAG/ZFYVE1/ATG2A/ATG14/RB1CC1/WIPI2/TSC2/PRKACA/ATG13/VPS16/GABARAPL1/EIF2AK4/UBA52/IRS2/VPS18/RRAGA/DAPK3/MAPK3/MLST8/AMBRA1/RRAGC/CAMKK2	4.44184045098152
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/897	95/9376	2.42060670069823	FLT1/HLA-DRA/CTSL/HLA-DRB1/HLA-DRB5/ITGAL/ATP6V1E1/CCL2/JUN/ATP6V0D1/HLA-DQA1/HLA-DPA1/HLA-DPB1/ATP6V0A2/TNF/ATP6V1B2/CXCL3/ATP6V0B/ACP5/ATP6AP1/CCL3L1/CCL3	4.52634671151848
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	43/897	248/9376	1.81234940842234	MYL9/DCTN2/CD14/DCTN4/DYNC1LI1/RAB7A/AKT2/TCF7L2/PIK3C2A/DYNLL2/JUN/ANXA2/DYNLRB1/RHOG/PKN1/MAPK14/RAB5C/DCTN5/RALA/FHOD1/EXOC7/GSDMD/NFKBIA/ACTR1A/DYNC1H1/KLC1/SNX9/AHNAK2/TNF/VPS16/MAP2K7/NAIP/TUBB6/TUBB4B/PLEKHM2/VPS18/DYNC2H1/DYNC2LI1/MAPK3/GAPDH/TUBA3E/MYO6/TUBA1C	4.21687216319114
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	41/897	238/9376	1.80066140168442	RPL13A/C1QB/C1QA/RPS26/RPS20/RPS11/CFD/PLCG2/C1QC/RPL8/RPLP0/RPS8/RPL28/RPS16/RPL7/RPL10/RPS28/RPL18A/EGFR/CCL2/C1R/JUN/IFNAR1/MAPK14/RPL37A/RPL26L1/NFKBIA/C5AR1/IFNAR2/IFIH1/TNF/UBA52/C1S/RPL13/RPL23/RPS4Y1/MAPK3/IL6ST/MAVS/RPS17/FGG	4.06931525298727
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/897	149/9376	1.96425070892535	MT-ND3/MT-ND1/MT-ND2/MT-ND4/NDUFA5/NDUFC1/MGLL/MT-ND5/NDUFA3/GNB5/NDUFS2/MAPK14/GNB1/MT-ND4L/NDUFS1/NDUFV1/PRKACA/NDUFB7/NDUFS6/GNG11/GNB2/CNR1/NDUFA1/NDUFB1/MT-ND6/NDUFS7/ITPR3/MAPK3	3.85888985698929
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	31/897	174/9376	1.86224836299799	CRYAB/BCAP29/OS9/SSR1/BAG1/UBXN2A/KRTCAP2/SELENOS/RPN1/UBE2G2/SEC61A1/STUB1/SEC63/GANAB/NPLOC4/STT3A/ERLEC1/LMAN2/BCAP31/PRKCSH/NSFL1C/MAP2K7/MAN1A1/AMFR/MAN1A2/SSR3/CKAP4/NFE2L2/CANX/DNAJC1/DNAJC5	3.73400960100793
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/897	205/9376	1.7845936318895	HLA-DRA/HLA-DRB1/PLCG2/HLA-DRB5/PSMD14/HDAC2/ITGAL/AKT2/PSMC1/PSMD3/PSMC5/ADRM1/PSMD1/JUN/HLA-G/IFNAR1/CDKN1A/HLA-DQA1/MAPK14/HLA-DPA1/RELB/HLA-DPB1/NFKBIA/PSMD7/IFNAR2/NFKB2/VIM/TNF/MAP2K7/LYN/E2F3/RBPJ/CD3G/ENTPD1/MAVS	3.69422127239274
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/897	38/9376	3.02575837587279	HEXB/PMM1/HEXA/NAGK/GNPNAT1/GALT/GMPPB/MPI/GPI/UXS1/GALK1	4.06969674539155
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	28/897	157/9376	1.86416150082724	MT-CO2/MT-CYB/MT-CO3/COX7A1/MT-CO1/NDUFA5/NDUFC1/AKT2/GSK3A/JUN/NDUFA3/NDUFS2/SDHC/MAPK14/PRKAG2/NDUFS1/NDUFV1/NDUFB7/NDUFS6/TNF/INSR/IRS2/UQCRC1/NDUFA1/NDUFB1/MAP3K11/MLXIP/NDUFS7	3.55150454671744
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/897	46/9376	2.72677039406718	PSMD14/PSMB7/PSMC1/PSMD3/PSMC5/PSME3/ADRM1/PSMB6/PSMD1/PSMD7/PSMB4/PSMB5	3.81840710984455
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	19/897	93/9376	2.13548147348989	HLA-DRA/HLA-DRB1/HLA-DRB5/PPP3CB/JUN/STAT6/HLA-DQA1/MAPK14/MAML1/MAF/HLA-DPA1/HLA-DPB1/NFKBIA/IL12RB1/CD4/RBPJ/CD3G/STAT5B/MAPK3	3.5792076402442
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	36/897	224/9376	1.67988533205925	HLA-DRA/HLA-DRB1/IL1R1/HLA-DRB5/IL1R2/ITGAL/AKT2/RANBP3/PPP3CB/XIAP/JUN/CREB3/HLA-G/EGR1/CREBBP/CDKN1A/HLA-DQA1/CREB1/SRF/HLA-DPA1/RELB/HLA-DPB1/NFKBIA/PRKACA/TGFBR1/NFKB2/TNF/CHEK2/CREB3L2/E2F3/CD4/ANAPC11/CD3G/STAT5B/CANX/MAPK3	3.34974091003595
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/897	109/9376	2.01380749286613	HLA-DRA/HLA-DRB1/EBI3/IL1R1/HLA-DRB5/PPP3CB/JUN/STAT6/HLA-DQA1/MAPK14/HLA-DPA1/HLA-DPB1/NFKBIA/TGFBR1/IL12RB1/CD4/CD3G/STAT5B/MAPK3/IL21R/IL6ST	3.46265088001206
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/897	88/9376	2.13803587716631	SERPINE2/C1QB/C1QA/SERPINE1/CFD/SERPING1/C1QC/F2R/CLU/C1R/TFPI/A2M/C5AR1/PLAUR/C1S/F3/CD59/FGG	3.4885562373937
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/897	82/9376	2.16700655300867	CD74/HLA-DRA/CTSL/HLA-DRB1/CTSB/HLA-DRB5/PSME3/HLA-G/HLA-DQA1/CREB1/HLA-DPA1/HLA-DPB1/TNF/CD4/CTSS/CANX/LGMN	3.45214022976455
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/897	56/9376	2.42650103519669	KRTCAP2/MAN2A1/RPN1/MGAT1/DPM3/GANAB/DPM2/STT3A/DHRSX/MAN1A1/ALG3/MAN1A2/MGAT4B	3.48231208941765
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/897	63/9376	2.32280440976093	POLR2G/XPC/POLE3/CUL4A/POLR2E/ERCC6/DDB1/POLD2/UVSSA/POLE4/POLR2I/CETN2/RFC3/LIG1	3.4263415227783
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/897	44/9376	2.61315496098105	HEXB/KRTCAP2/MAN2A1/RPN1/MGAT1/HEXA/STT3A/MAN1A1/ALG3/MAN1A2/MGAT4B	3.48838655010612
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/897	99/9376	2.00605835388444	HLA-DRA/C1QB/C1QA/KRT18/KRT19/HLA-DRB1/CFD/C1QC/HLA-DRB5/SELPLG/ITGAL/C1R/HLA-DQA1/FCGR3A/HLA-DPA1/HLA-DPB1/C5AR1/C1S/FGG	3.2730039746123
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/897	71/9376	2.20829996702624	PLCG2/ATP6V1E1/EGFR/JUN/ATP6V0D1/MAPK14/NFKBIA/ATP6V0A2/LYN/ATP6V1B2/CXCL3/ATP6V0B/JAM2/ATP6AP1/TJP1	3.32395619178932
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/897	51/9376	2.45943996327628	PLCG2/ATP6V1E1/SEC61A1/KDELR2/ATP6V0D1/PRKACA/ATP6V0A2/KDELR1/ATP6V1B2/ATP6V0B/ATP6AP1/TJP1	3.39904132027562
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/897	250/9376	1.58879821627648	RAB31/CAV1/EHD1/CHMP4B/USP8/EGFR/RAB11A/RABEP1/RAB7A/AP2A1/VPS35/VPS4A/DAB2/CHMP1A/HLA-G/AP2M1/SPG21/WIPF2/CHMP6/RAB5C/WWP1/EHD2/TGFBR1/WASHC3/EEA1/EHD4/CLTA/AP2B1/AGAP3/AP2S1/CAPZB/CHMP3/ARFGAP1/CAV2/TFRC/PLD1/FOLR2/EPN1	3.06906297453968
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	47/897	333/9376	1.475294692686	FN1/SPP1/UBR4/HDAC2/ITGB8/ATP6V1E1/EGFR/AKT2/COL6A3/PSMC1/TCF7L2/WNT5A/ATP6V0D1/CREB3/HLA-G/NFX1/IFNAR1/CREBBP/CDKN1A/WNT4/CREB1/MAML1/ITGA1/TSC2/IFNAR2/PRKACA/BCAP31/PPP2R1A/ATP6V0A2/DLG3/TNF/AXIN1/CREB3L2/RBPJ/ATP6V1B2/LAMA3/ATP6V0B/COL1A1/LAMA4/DVL3/COL6A2/RFNG/EIF4EBP1/MAPK3/TNXB/ATP6AP1/PTGER4	2.87235661415573
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	35/897	233/9376	1.57013602805728	FN1/DCN/FBLN1/MYL9/TPM1/VCAN/ITGB8/SUN1/VCL/COL6A3/PDLIM1/FBN1/ENO2/TTN/PDLIM4/BGN/TPM2/CSRP1/ITGA1/DSP/DAAM1/ZYX/NID1/VIM/DIAPH2/CAPZB/PDLIM7/FHL2/ATP1B3/SYNE1/COL1A1/HSPG2/COL6A2/COL5A1/EMD	2.86629990011849
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/897	105/9376	1.89142644794819	GABARAP/USP8/RAB7A/JUN/TBC1D15/RABGEF1/MUL1/RAB5C/SP1/GABARAPL1/AMFR/UBA52/MTX1/FOXO3/MON1B/FKBP8/MFN2/AMBRA1/RHOT2	2.98762727925774
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	24/897	144/9376	1.7421033073207	PSMD14/PSMB7/WIPI1/AKT2/PSMC1/PSMD3/PSMC5/ADRM1/PSMB6/PSMD1/ATG2A/SP1/ATG14/RB1CC1/WIPI2/CIC/PSMD7/ATG13/PSMB4/RBPJ/PPIF/ITPR3/AMBRA1/PSMB5	2.91881962313018
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/897	203/9376	1.5962128825697	FN1/FLT1/MYL9/SPP1/CAV1/ITGB8/VCL/EGFR/ILK/AKT2/COL6A3/ARHGAP5/XIAP/JUN/ITGA1/VEGFB/ZYX/KDR/CRK/PPP1R12C/LAMA3/CAV2/EMP1/COL1A1/LAMA4/COL6A2/PARVA/MAPK3/TNXB/PPP1CA/RAPGEF1	2.79320763215098
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/897	30/9376	2.78736529171312	PIGF/MPPE1/DPM2/PIGX/PIGP/PIGQ/B3GALT4/PIGT	3.18911809224856
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/897	37/9376	2.5425291512248	PMM1/NAGK/GNPNAT1/GALT/GMPPB/MPI/GPI/UXS1/GALK1	3.05769101193752
Genetic Information Processing	Translation	hsa03010	Ribosome	33/897	222/9376	1.55376781463738	RPL13A/RPS26/RPS20/RPS11/RPL8/RPLP0/RPS8/RPL28/RPS16/RPL7/MRPS5/RPL10/RPS28/RPL18A/MRPL40/MRPL55/MRPS18B/MRPL41/MRPL20/RPL37A/MRPL28/MRPL12/RPL26L1/MRPS21/MRPL37/MRPL23/UBA52/MRPL24/RPL13/RPL23/RPS4Y1/MRPL27/RPS17	2.71586567319946
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/897	142/9376	1.69302997472012	PLCG2/IL1R1/AKT2/PPP3CB/JUN/IFNAR1/CREB1/MAPK14/FCGR3A/CYBA/RELB/NFKBIA/IFNAR2/TGFBR1/NFKB2/TNF/MAP2K7/TNFRSF11B/FHL2/ITPR3/ACP5/MAPK3/GAB2	2.70651724220753
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/897	32/9376	2.61315496098105	GABARAP/WIPI1/ATG10/ATG2A/WIPI2/ATG13/GABARAPL1/MLST8	2.97299517547686
Human Diseases	Immune disease	hsa05310	Asthma	8/897	32/9376	2.61315496098105	HLA-DRA/PRG2/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-DPB1/TNF	2.97299517547686
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/897	10/9376	4.18104793756968	TST/PAPSS2/ETHE1/SQOR	3.27342714299559
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/897	83/9376	1.8890276826369	HDAC2/PHC2/CREBBP/USP16/EZH1/SFMBT1/CBX3/CBX6/MBD6/CBX7/L3MBTL3/RING1/WDR5/FBRSL1/E2F6	2.64597602032262
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/897	42/9376	2.23984710941233	FTH1/FTL/SAT1/SLC40A1/PRNP/GPX4/GCLM/TFRC/ACSL1	2.61919855735227
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/897	17/9376	3.07429995409535	MTR/PAPSS2/KYAT3/SCLY/PSTK	2.78413850609165
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/897	205/9376	1.47866329499415	UBR4/SND1/HDAC2/PSMC1/MAPKAPK2/YWHAG/JUN/ATP6V0D1/MRPS18B/CREB3/HLA-G/CREBBP/CDKN1A/YWHAQ/CREB1/SRF/DDB1/HDAC7/NFKBIA/PRKACA/NFKB2/YWHAH/GTF2E2/CREB3L2/LYN/RBPJ/STAT5B/MAPK3/IL6ST	2.25376303708014
NA	NA	hsa04518	Integrin signaling	23/897	154/9376	1.56110556110556	FN1/FLT1/SPP1/FERMT2/ITGAL/ITGB8/VCL/EGFR/ILK/AKT2/COL6A3/FBN1/ITGA1/VEGFB/KDR/LIMS2/LAMA3/COL1A1/LAMA4/COL6A2/PARVA/TNXB/FGG	2.28350473548247
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/897	66/9376	1.90047633525894	HLA-DRA/HLA-DRB1/HLA-DRB5/JUN/STAT6/HLA-DQA1/MAF/HLA-DPA1/HLA-DPB1/TNF/IL12RB1/IL21R	2.38769567804764
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/897	130/9376	1.60809536060372	MMP2/EGFR/AKT2/JUN/CREB3/GNB5/CREB1/MAPK14/VEGFB/GNB1/NFKBIA/PRKACA/TGFBR1/MAP2K7/CREB3L2/GNG11/GNB2/RXFP1/COL1A1/MAPK3	2.27078472260775
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	26/897	181/9376	1.50148130354712	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/CD14/RAB7A/AKT2/PPP3CB/ATP6V0D1/CREBBP/HLA-DQA1/CREB1/MAPK14/RAB5C/FCGR3A/HLA-DPA1/HLA-DPB1/EEA1/ATP6V0A2/TNF/IRAK2/MRC1/CTSS/ATP6V0B/MAPK3/ATP6AP1	2.21578546322154
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/897	75/9376	1.81178743961353	ALDH18A1/MTR/ACO2/PYCR2/ENO2/PRPS2/IDH3G/PYCR1/GOT2/IDH1/ASNS/ALDOC/GAPDH	2.29571345187733
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/897	39/9376	2.14412714747163	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-G/HLA-DQA1/HLA-DPA1/HLA-DPB1/TNF	2.32869417438928
Cellular Processes	Cell motility	hsa04814	Motor proteins	27/897	194/9376	1.45474606075234	MYL9/TPM1/DCTN2/DCTN4/DYNC1LI1/DYNLL2/DYNLRB1/KIF21A/MYL6/TPM2/DCTN5/MYO1G/ACTR1A/DYNC1H1/MYO5A/KLC1/KIF1B/CAPZB/TUBB6/TUBB4B/MYO10/MYO18A/DYNC2H1/DYNC2LI1/TUBA3E/MYO6/TUBA1C	2.08166436839587
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/897	101/9376	1.65586056933453	FN1/SERPINE1/PLCG2/MMP2/AKT2/CCL2/JUN/EGR1/MAPK14/VEGFB/TGFBR1/TNF/STAT5B/COL1A1/F3/MAPK3	2.15538467930628
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/897	62/9376	1.85449706908332	HDAC2/SPEN/APH1A/CTBP1/CREBBP/MAML1/APH1B/RBPJ/NCSTN/DVL3/RFNG	2.19557282839641
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/897	204/9376	1.43467331191116	TIMP3/FN1/LUM/DCN/CTSL/PLCG2/CAV1/MMP2/EGFR/AKT2/WNT5A/CDKN1A/WNT4/MAPK14/KDR/PRKACA/TNF/DROSHA/SLC9A1/FRS2/PLAUR/PPP1R12C/CAV2/COL1A1/HSPG2/ITPR3/MAPK3/PPP1CA	2.04152911977802
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/897	78/9376	1.7421033073207	HLA-DRA/HLA-DRB1/HLA-DRB5/JUN/HLA-DQA1/MAPK14/FCGR3A/CYBA/HLA-DPA1/HLA-DPB1/NFKBIA/TNF/MAPK3	2.14055523867467
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	27/897	196/9376	1.43990171319364	PLCG2/AKT2/MAPKAPK2/TCF7L2/PPP3CB/JUN/HLA-G/GNB5/IFNAR1/CREBBP/CDKN1A/CREB1/MAPK14/ATG14/GNB1/NFKBIA/IFNAR2/MAP2K7/LYN/GNG11/UBA52/GNB2/E2F3/CXCL3/ITPR3/MAPK3/IL6ST	2.02428608843325
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/897	55/9376	1.90047633525894	PSAP/HEXB/PLPP3/HEXA/ASAH1/SMPD4/CERS4/SGPP1/PLPP1/ARSA	2.17837145168113
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/897	103/9376	1.62370793692026	C1QB/C1QA/SERPINE1/C1QC/AKT2/CCL2/JUN/MAPK14/NFKBIA/TGFBR1/PPP2R1A/TNF/CD3G/MAPK3/CCL3L1/CCL3	2.0701379892355
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/897	103/9376	1.62370793692026	FN1/HSPB1/IL1R1/CD14/PRDX1/IL1R2/VCL/RAB7A/RAB5C/PRKACA/TNF/SERPINB6/LAMA3/CXCL3/COL1A1/LAMA4	2.0701379892355
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/897	163/9376	1.47490954852918	AKT2/JUN/STAT6/CREB3/IFNAR1/CREBBP/CDKN1A/YWHAQ/CREB1/MAPK14/DDB1/NFKBIA/TGFBR1/IFIH1/TNF/MAP2K7/CREB3L2/E2F3/STAT5B/HSPG2/MAPK3/ATP6AP1/MAVS	1.98936150683494
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/897	34/9376	2.15200996786675	POLR2G/POLR3D/POLR2E/POLR1C/POLR1A/POLR2I/POLR3H	2.18869530350183
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/897	90/9376	1.62596308683265	AKT2/CREB3/CREB1/RB1CC1/PRKAG2/TSC2/PRKACA/ATG13/CREB3L2/INSR/FOXO3/IRS2/EIF4EBP1/CAMKK2	1.94073027436887
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/897	99/9376	1.58373027938245	PLPP3/EGFR/AKT2/JUN/PCYT1A/DGKA/SP1/TSC2/RALGDS/CHPT1/PLD1/SLC44A2/EIF4EBP1/MAPK3/PLPP1	1.89904642920919
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/897	116/9376	1.53184945988544	G6PD/ACO2/ENO2/PRPS2/IDH3G/OGDH/SDHC/ACSS1/GOT2/GCSH/IDH1/PGLS/MCEE/ALDOC/GPI/ACAT1/GAPDH	1.87465677569886
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/897	100/9376	1.56789297658863	HLA-DRA/HLA-DRB1/IL1R1/HLA-DRB5/CD14/IL1R2/HLA-DQA1/ITGA1/HLA-DPA1/HLA-DPB1/TNF/CD4/TFRC/CD3G/CD59	1.8569305861156
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/897	44/9376	1.90047633525894	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-G/HLA-DQA1/HLA-DPA1/HLA-DPB1/TNF	1.94724599470333
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	16/897	109/9376	1.53432951837419	AKT2/CREB3/CREB1/PTPN1/TBC1D4/NFKBIA/PRKAG2/TNF/CREB3L2/INSR/PYGB/PTPRF/IRS2/MLXIP/RPS6KA2/PPP1CA	1.82499793110045
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/897	110/9376	1.52038106820716	FLT1/TIMP1/SERPINE1/PLCG2/EGFR/AKT2/ENO2/CREBBP/ELOB/CDKN1A/INSR/TFRC/ALDOC/EIF4EBP1/MAPK3/GAPDH	1.78558786186169
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/897	180/9376	1.39368264585656	CD74/HLA-DRA/HLA-DRB1/HLA-DRB5/AKT2/CCL2/POU2F1/HLA-G/IFNAR1/HLA-DQA1/HLA-DPA1/DAXX/HLA-DPB1/NFKBIA/RNASEL/TSC2/IFNAR2/IFIH1/TNF/EIF2B4/TNFRSF14/EIF4EBP1/PPP1CA/MAVS	1.73457300882025
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/897	77/9376	1.62897971593624	HDAC2/AKT2/CTBP1/CDKN1A/NFKBIA/CRK/TGFBR1/E2F3/STAT5B/MAPK3/BCR/GAB2	1.80249231125746
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/897	45/9376	1.85824352780875	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-G/HLA-DQA1/HLA-DPA1/HLA-DPB1/TNF	1.87699122061311
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/897	30/9376	2.09052396878484	MTR/FPGS/TNF/MTHFR/ABCC4/FOLR2	1.94577445081139
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/897	53/9376	1.77497318104373	RAB11A/AP2A1/AP2M1/PRKACA/CLTA/AP2B1/AP2S1/ATP2B1/ATP1B3	1.84016305969152
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/897	155/9376	1.41616139820908	USP8/EGFR/TCF7L2/WNT5A/CREB3/CDKN1A/WNT4/CREB1/NR4A1/SP1/CYP11A1/PRKACA/AXIN1/HSD3B1/CREB3L2/E2F3/KCNK3/DVL3/WDR5/ITPR3/MAPK3	1.69921437770762
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/897	227/9376	1.33535672014891	IL1R1/EGFR/AKT2/CCL2/PPP3CB/CREB3/HLA-G/GNB5/CDKN1A/CREB1/MAPK14/SP1/GNB1/NFKBIA/TSC2/CRK/PRKACA/TNF/CREB3L2/GNG11/GNB2/E2F3/CCL4L2/ITPR3/EIF4EBP1/MAPK3/CCL3L1/CCL3/PTGER4	1.66357609238212
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/897	31/9376	2.02308771172726	GRHPR/ACO2/ACSS1/GCSH/MCEE/ACAT1	1.85572494028232
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/897	31/9376	2.02308771172726	TMEM208/OXA1L/SEC61A1/SEC63/BAG6/SGTA	1.85572494028232
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/897	63/9376	1.65914600697209	KMT5B/DOT1L/KMT2C/KMT2B/EZH1/KMT5C/PLOD3/COLGALT1/SETD1B/ACAT1	1.70732673447178
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/897	158/9376	1.38927225773676	LAMTOR5/ATP6V1E1/AKT2/WNT5A/CLIP1/WNT4/MAPKAP1/TSC2/LAMTOR1/TNF/INSR/ATP6V1B2/DVL3/RRAGA/RPS6KA2/EIF4EBP1/MAPK3/MLST8/RRAGC/LAMTOR4/NPRL3	1.6049931663558
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/897	362/9376	1.24160953947166	FN1/FLT1/SPP1/PRL/PRLR/F2R/ITGB8/CDC37/EGFR/AKT2/COL6A3/YWHAG/CREB3/CSH1/GNB5/IFNAR1/CDKN1A/PKN1/YWHAQ/CREB1/ITGA1/NR4A1/VEGFB/GNB1/TSC2/KDR/IFNAR2/YWHAH/PPP2R1A/CREB3L2/GNG11/GNB2/SGK3/INSR/LAMA3/FOXO3/COL1A1/LAMA4/COL6A2/EIF4EBP1/MAPK3/MLST8/TNXB	1.52482192530813
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/897	98/9376	1.49323140627488	PLCG2/MARCKS/PLPP3/AKT2/FCGR3A/INPPL1/CRK/LYN/MYO10/PLD1/LIMK2/MAPK3/GAB2/PLPP1	1.59641617024545
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/897	142/9376	1.39858997911662	MGRN1/UBE2G2/CUL4A/XIAP/STUB1/UBE2K/ELOB/WWP1/UBE2R2/DDB1/KEAP1/FBXW11/UBA52/UBE3C/ANAPC11/KLHL9/PIAS3/CDC34/WWP2	1.55662913640343
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/897	73/9376	1.57505230524885	AFF4/MAP1B/CHMP4B/VPS4A/PIN1/CREBBP/CHMP6/SERINC3/SUPT5H/CD4/NELFE	1.6042306531286
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/897	18/9376	2.32280440976093	PRDX1/MTR/MTRR/ABCD4	1.82704779387152
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/897	65/9376	1.60809536060372	CREB3/CREB1/NR4A1/SP1/CYP11A1/PRKACA/HSD3B1/CREB3L2/KCNK3/ITPR3	1.600072816598
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/897	57/9376	1.65041365956698	ACAA1/ELOVL5/ELOVL1/ACSF3/MECR/PPT1/ACSL1/ACAT1/TECR	1.60196110551441
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/897	109/9376	1.43843392347581	SPP1/CD14/AKT2/JUN/IFNAR1/MAPK14/NFKBIA/IFNAR2/TNF/MAP2K7/TOLLIP/CCL4L2/MAPK3/CCL3L1/CCL3	1.49746734131813
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/897	50/9376	1.67241917502787	AOC1/SAT1/ALDH18A1/PYCR2/MAOA/PYCR1/GOT2/SMOX	1.55055411604118
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/897	34/9376	1.84457997245721	RORB/FBXL3/CREB1/PRKAG2/FBXW11/CSNK1E	1.60461130607389
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/897	93/9376	1.46111890291413	MYL9/VCL/EGFR/TCF7L2/KRIT1/CREBBP/PTPN1/TGFBR1/INSR/PTPRF/AFDN/MAPK3/TJP1	1.4535158335069
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/897	138/9376	1.36338519703359	AKT2/PTPN1/PHKG1/EXOC7/INPPL1/PRKAG2/TSC2/CRK/PRKAR2A/PRKACA/INSR/PYGB/PTPRF/IRS2/EIF4EBP1/MAPK3/PPP1CA/RAPGEF1	1.39870889938578
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/897	51/9376	1.63962664218419	PAFAH1B2/PLPP3/CHPT1/PLD1/PAFAH1B3/LPCAT1/ENPP2/PLPP1	1.48969292402584
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/897	43/9376	1.70158927691789	PLPP3/APOA1/GOT2/AGPAT1/DGAT1/ACAT1/PLPP1	1.49974036190882
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/897	112/9376	1.3999044433827	HLA-DRA/HLA-DRB1/HLA-DRB5/AKT2/XIAP/HLA-DQA1/MAPK14/HLA-DPA1/HLA-DPB1/NFKBIA/TNF/LAMA3/LAMA4/PPIF/MAPK3	1.3847631879375
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/897	52/9376	1.60809536060372	APOE/APOC1/LRPAP1/PLTP/APOA1/VAPB/NPC2/NPC1	1.4301505962549
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/897	214/9376	1.26994446701883	PLCG2/AKT2/PPP3CB/CUL4A/JUN/HLA-G/GNB5/ELOB/MAPK14/AP1G2/AP1S2/DDB1/GNB1/NFKBIA/CRK/TNF/MAP2K7/GNG11/FBXW11/GNB2/CD4/AP1M1/CD3G/LIMK2/ITPR3/MAPK3	1.29925894449849
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/897	44/9376	1.66291679335158	TAF2/TAF1/TAF10/TAF3/TAF5/GTF2E2/TAF6	1.43353247623573
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/897	44/9376	1.66291679335158	POLE3/PNKP/POLD2/POLE4/XRCC1/RFC3/LIG1	1.43353247623573
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/897	78/9376	1.47408741388674	C1QB/C1QA/SERPING1/C1QC/CD14/C1R/JUN/MAPK14/TNF/C1S/MAPK3	1.36747847284078
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/897	28/9376	1.86653925784361	ELOVL5/ELOVL1/MECR/PPT1/TECR	1.49354203029909
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/897	36/9376	1.7421033073207	POLE3/RNASEH2C/POLD2/POLE4/RFC3/LIG1	1.45094757660748
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/897	61/9376	1.542189813038	FTH1/FTL/SLC40A1/SLC39A4/SLC31A1/HMOX2/ATP2B1/ATP1B3/CYBRD1	1.38176562262399
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/897	187/9376	1.28561634443987	CTSB/GABARAP/CCL2/XIAP/JUN/IFNAR1/PKN1/MAPK14/CYBA/GSDMD/NFKBIA/RNASEL/IFNAR2/GBP1/TNF/GABARAPL1/NAIP/CXCL3/ITPR3/MFN2/MAPK3/GBP5/MAVS	1.28315545913046
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/897	79/9376	1.45542807953375	ATP6V1E1/AP2A1/NAPA/ATP6V0D1/AP2M1/ATP6V0A2/CLTA/AP2B1/AP2S1/ATP6V1B2/ATP6V0B	1.3221218294662
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/897	142/9376	1.32497998021574	CTSL/IL1R1/CAV1/IL1R2/MMP2/AKT2/CCL2/JUN/MAPK14/CYBA/KEAP1/KDR/TNF/MAP2K7/GSTO1/MGST3/NFE2L2/CAV2	1.2691571099524
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/897	133/9376	1.33604915298279	AKT2/GSK3A/PPP3CB/COMT/CREB3/GNB5/CREB1/MAPK14/MAOA/GNB1/PRKACA/PPP2R1A/CREB3L2/GNG11/GNB2/ITPR3/PPP1CA	1.26949703576385
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/897	62/9376	1.51731578379545	CRYAB/HDAC2/AKT2/EIF4EBP2/PRKAG2/PRKACA/INSR/FOXO3/IRS2	1.32920816196635
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/897	21/9376	1.99097520836651	B3GAT3/B3GALT6/CHSY1/B4GALT7	1.47863194019547
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/897	117/9376	1.34007946716977	POLE3/HDAC2/EP400/BAZ2B/SMARCD2/CHRAC1/INO80E/BAZ2A/BAZ1A/ZNHIT1/SMARCA4/MTA3/RSF1/MORF4L1/NFRKB	1.20392890755208
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/897	30/9376	1.7421033073207	ACO2/IDH3G/OGDH/SDHC/IDH1	1.3241026300928
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/897	137/9376	1.29704041858913	CTSL/CTSB/AKT2/XIAP/JUN/DAXX/NFKBIA/CSF2RB/TNF/CTSH/ENDOG/CTSS/ITPR3/CTSZ/MAPK3/TUBA3E/TUBA1C	1.1391289529166
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/897	56/9376	1.49323140627488	CD14/RAB1A/RAB1B/NFKBIA/NFKB2/TNF/NAIP/CXCL3	1.20405498949721
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/897	15/9376	2.09052396878484	HEXB/HEXA/B3GALT4	1.37476752446596
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/897	31/9376	1.68590642643939	G6PD/PRPS2/PGLS/ALDOC/GPI	1.24412955766476
NA	NA	hsa04981	Folate transport and metabolism	5/897	31/9376	1.68590642643939	MTR/FPGS/MTHFR/ABCC4/FOLR2	1.24412955766476
NA	NA	hsa03272	Virion - Hepatitis viruses	7/897	48/9376	1.52434039390561	CHMP4B/CD81/EGFR/VPS4A/CHMP1A/CLDN5/HSPG2	1.18453857442105
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/897	120/9376	1.30657748049052	PLCG2/AKT2/MAPKAPK2/JUN/MAPK14/NFKBIA/CRK/MAP2K7/FRS2/IRAK2/FOXO3/BEX3/RPS6KA2/MAPK3/RAPGEF1	1.09933167871638
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/897	122/9376	1.28515817753166	IGFBP3/PLCG2/AKT2/CREB3/CSH1/CREBBP/CREB1/MAPK14/CRK/PRKACA/CREB3L2/IRS2/STAT5B/ITPR3/MAPK3	1.03112315680402
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/897	24/9376	1.7421033073207	B3GAT3/EXT1/B3GALT6/B4GALT7	1.18393342273615
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/897	41/9376	1.52965168447671	MMP2/EGFR/CDKN1A/E2F3/DAPK3/MAPK3	1.10543870643265
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/897	77/9376	1.35748309661353	EGFR/AKT2/CDKN1A/RALA/TGFBR1/RALBP1/RALGDS/E2F3/PLD1/MAPK3	1.0244535979849
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/897	59/9376	1.41730438561684	G6PD/GPX4/GPX3/IDH1/GSTO1/MGST3/GCLM/LANCL1	1.04580436237406
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/897	59/9376	1.41730438561684	EGFR/ILK/AKT2/TCF7L2/CDKN1A/AXIN1/FOXO3/MAPK3	1.04580436237406
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/897	133/9376	1.25745802633674	GABARAP/EGFR/AKT2/DEPP1/CREBBP/CDKN1A/MAPK14/PRKAG2/TGFBR1/GABARAPL1/SGK3/CSNK1E/INSR/FOXO3/IRS2/MAPK3	0.972602365954617
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/897	33/9376	1.58373027938245	ACO2/IDH3G/OGDH/GOT2/IDH1	1.09253550456948
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/897	115/9376	1.27249285056468	EGFR/PDE4A/CREB3/EGR1/CDKN1A/CREB1/SP1/WNK1/PRKACA/CREB3L2/PLD1/MMP25/ITPR3/MAPK3	0.956279029849439
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/897	69/9376	1.36338519703359	HDAC2/PPP3CB/JUN/CREB3/CREB1/MAOA/PRKACA/CREB3L2/PPP1CA	0.985363480166121
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/897	106/9376	1.28192507519825	IL1R2/EGFR/AKT2/TCF7L2/CREB3/CREBBP/CDKN1A/CREB1/NFKBIA/CREB3L2/E2F3/FOLR2/MAPK3	0.949415488927782
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/897	60/9376	1.39368264585656	HSPB1/PLCG2/AKT2/MAPKAPK2/PPP3CB/MAPK14/KDR/MAPK3	0.99498537720209
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/897	300/9376	1.14978818283166	FLT1/HSPB1/IL1R1/CD14/EGFR/AKT2/MAPKAPK2/MAP4K4/PPP3CB/JUN/MAPK14/MAP3K13/NR4A1/SRF/DAXX/VEGFB/RELB/KDR/CRK/PRKACA/MAP3K2/TGFBR1/NFKB2/TNF/MAP2K7/PPP5C/MAPK8IP3/INSR/RASGRP2/MAP3K11/RASA1/RPS6KA2/MAPK3	0.857631014400546
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/897	193/9376	1.19149034490328	PLCG2/CXCL14/AKT2/CCL2/GSK3A/GNB5/GNB1/NFKBIA/CRK/PRKACA/CCL18/LYN/GNG11/GNB2/RASGRP2/CXCL3/FOXO3/STAT5B/CCL4L2/MAPK3/CCL3L1/CCL3	0.874264382919906
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/897	70/9376	1.3439082656474	HLA-DRA/HLA-DRB1/HLA-DRB5/CAV1/ITGAL/HLA-G/HLA-DQA1/HLA-DPA1/HLA-DPB1	0.939333155808402
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/897	98/9376	1.2799126339499	PRKD2/CREB3/CREB1/NR4A1/CYP11A1/PRKACA/HSD3B1/CREB3L2/KCNK3/ATP2B1/ATP1B3/ITPR3	0.905978511118124
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/897	89/9376	1.29189683464232	FN1/SPP1/ITGB8/COL6A3/ITGA1/LAMA3/COL1A1/LAMA4/HSPG2/COL6A2/TNXB	0.899904053659438
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/897	89/9376	1.29189683464232	EGFR/GJA1/PRKACA/MAP3K2/TUBB6/TUBB4B/ITPR3/MAPK3/TUBA3E/TJP1/TUBA1C	0.899904053659438
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	13/897	108/9376	1.25818572195384	KPNB1/UPF1/UPF2/AHCTF1/RANGAP1/XPO7/THOC2/KPNA6/TPR/POM121/NUP62/AAAS/SNUPN	0.877729366113479
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	28/897	253/9376	1.15681168233153	MYL9/PLCG2/IL1R1/CD14/TNIP1/WIPI1/VCL/EGFR/ILK/AKT2/GSK3A/JUN/MAPK14/ATG14/CBX3/WIPI2/NFKBIA/CRK/TNF/NAIP/FBXW11/UBA52/FOXO3/RRAGA/ITPR3/MAPK3/RRAGC/TECPR1	0.822392951316434
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/897	156/9376	1.20607152045279	CD81/EGFR/AKT2/YWHAG/PSME3/IFNAR1/CDKN1A/YWHAQ/CLDN5/NFKBIA/RNASEL/IFNAR2/YWHAH/PPP2R1A/TNF/E2F3/MAPK3/MAVS	0.84415919657577
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/897	35/9376	1.49323140627488	PMM1/ENOSF1/ALDOC/GMPPB/MPI	0.95081845041515
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/897	157/9376	1.19838953624609	IGFBP3/SERPINE1/AKT2/MAPKAPK2/PPP3CB/HLA-G/CDKN1A/MAPK14/TSC2/TGFBR1/CHEK2/FBXW11/E2F3/FOXO3/ITPR3/EIF4EBP1/MAPK3/PPP1CA	0.815335257732098
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/897	18/9376	1.7421033073207	ACSF3/MECR/ACSL1	1.02498767048265
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/897	110/9376	1.23530961791831	DCN/EMP3/HDAC2/FBN1/CREBBP/LTBP1/SP1/TGFBR1/PPP2R1A/TNF/TGIF2/TFRC/MAPK3	0.807419837508368
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/897	27/9376	1.54853627317395	ACAA1/ELOVL5/ELOVL1/TECR	0.928355245853914
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/897	54/9376	1.35496923902721	AHCYL1/MTR/TST/GOT2/KYAT3/GCLM/CISD1	0.85082960357341
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/897	54/9376	1.35496923902721	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-G/HLA-DQA1/HLA-DPA1/HLA-DPB1	0.85082960357341
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/897	19/9376	1.65041365956698	HEXB/HEXA/GALNS	0.923012709840359
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/897	93/9376	1.23633137938888	MMP2/EGFR/JUN/EGR1/MAPK14/PRKACA/MAP3K2/MAP2K7/PLD1/ITPR3/MAPK3	0.744951897927794
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	14/897	122/9376	1.19948096569622	PLCG2/HDAC2/AKT2/DIO2/CREBBP/WNT4/TBC1D4/TSC2/PRKACA/MED16/MED12/SLC9A1/ATP1B3/MAPK3	0.721317006762539
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/897	37/9376	1.41251619512489	TCF7L2/CCDC6/CDKN1A/TPR/MAPK3	0.817713597898946
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/897	28/9376	1.49323140627488	ATP6V1E1/ATP6V0D1/ATP6V0A2/ATP6V1B2	0.850119402285659
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/897	173/9376	1.14797558979514	HLA-DRA/HLA-DRB1/HLA-DRB5/RAB11A/AKT2/CCL2/IFNAR1/CREBBP/HLA-DQA1/HLA-DPA1/HLA-DPB1/NFKBIA/RNASEL/IFNAR2/IFIH1/KPNA6/TNF/MAPK3/MAVS	0.638936888187839
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/897	105/9376	1.19458512501991	PLCG2/AKT2/MAPKAPK2/PPP3CB/JUN/MAPK14/RELB/NFKBIA/NFKB2/TNF/ITPR3/MAPK3	0.652154565287303
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/897	154/9376	1.1538606321215	PMM1/UROS/COQ4/AK3/NAPRT/FLAD1/COASY/PDXK/PNPO/FPGS/GCLM/RDH13/PTS/GMPPB/MPI/VKORC1/NME4	0.626159329737381
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/897	86/9376	1.21542091208421	PLCG2/EGFR/AKT2/JUN/CDKN1A/CRK/MAP2K7/STAT5B/EIF4EBP1/MAPK3	0.65273781153174
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/897	87/9376	1.2014505567729	MT-CO2/MT-CYB/MT-CO3/TPM1/COX7A1/MT-CO1/TPM2/SLC9A1/ATP1B3/UQCRC1	0.613978493641081
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/897	87/9376	1.2014505567729	EGFR/AKT2/TCF7L2/JUN/CDKN1A/RALA/TGFBR1/AXIN1/RALGDS/MAPK3	0.613978493641081
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/897	12/9376	1.7421033073207	COQ4/VKORC1	0.836630763224561
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/897	49/9376	1.2799126339499	GALNT15/PLOD3/COLGALT1/GALNT10/RFNG/POFUT2	0.63893855414822
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/897	49/9376	1.2799126339499	JUN/CREB3/CREB1/MAOA/PRKACA/CREB3L2	0.63893855414822
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/897	78/9376	1.20607152045279	PLCG2/ITPK1/PIK3C2A/PI4KA/SYNJ2/INPPL1/PI4K2A/CDIPT/INPP5K	0.594401707006884
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/897	157/9376	1.13181233978797	SERPINE1/TCF7L2/YWHAG/WNT5A/WNT4/YWHAQ/TGFBR1/YWHAH/NF2/PPP2R1A/DLG3/AXIN1/TEAD1/FBXW11/CSNK1E/DVL3/PPP1CA	0.541718328833564
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/897	69/9376	1.21189795291875	PLCG2/AKT2/MAPK14/TNF/MAP2K7/LYN/MAPK3/GAB2	0.574587259009323
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/897	138/9376	1.13615433086133	FN1/AKT2/CCL2/JUN/WIPF2/RHOG/PKN1/MAPK14/NFKBIA/CRK/TNF/MAP2K7/CD4/RPS6KA2/MAPK3	0.52407273554417
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/897	50/9376	1.2543143812709	HLA-DRA/HLA-DRB1/HLA-DRB5/HLA-DQA1/HLA-DPA1/HLA-DPB1	0.586432132355121
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/897	119/9376	1.14188284009256	AKT2/CCL2/XIAP/JUN/CREB3/CREB1/MAPK14/NFKBIA/TNF/MAP2K7/CREB3L2/CXCL3/MAPK3	0.506614673133971
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/897	70/9376	1.19458512501991	AKT2/JUN/CREBBP/ELOB/CDKN1A/CRK/MAPK3/RAPGEF1	0.531479693325324
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/897	200/9376	1.09752508361204	IL1R1/F2R/RAB1A/JUN/WIPF2/MAPK14/MYO1G/CLDN5/NFKBIA/MYO5A/TNF/NAIP/TUBB6/TUBB4B/MYO10/MAPK3/GAPDH/TUBA3E/TJP1/MYO6/TUBA1C	0.453434090761135
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/897	170/9376	1.10674798347433	PLCG2/EGFR/AKT2/SMARCD2/TCF7L2/WNT5A/CDKN1A/WNT4/KEAP1/TGFBR1/SMARCA4/AXIN1/GSTO1/MGST3/E2F3/NFE2L2/DVL3/MAPK3	0.456833766785491
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/897	160/9376	1.11059085841695	HLA-DRA/HLA-DRB1/HLA-DRB5/VCAN/GLG1/SELPLG/ITGAL/ITGB8/HLA-G/HLA-DQA1/VSIR/HLA-DPA1/CLDN5/HLA-DPB1/CD4/PTPRF/JAM2	0.458899441867418
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/897	71/9376	1.17775998241399	PRL/PRLR/AKT2/MAPK14/FOXO3/STAT5B/GALT/MAPK3	0.489006381131949
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/897	91/9376	1.14863954328837	PLCG2/CD81/AKT2/PPP3CB/JUN/INPPL1/NFKBIA/LYN/IFITM1/MAPK3	0.463418798027013
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/897	23/9376	1.36338519703359	POLD2/RFC3/LIG1	0.567499162192252
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/897	33/9376	1.26698422350596	SNAP29/STX11/VAMP3/VTI1B	0.499699525007963
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/897	83/9376	1.13341660958214	PRDX1/ACAA1/PEX26/IDH1/PEX19/HMGCL/ABCD4/ACSL1/PEX11B	0.39708229176849
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/897	83/9376	1.13341660958214	POLR3D/POLR2E/POLR1C/GSDMD/NFKBIA/DDX41/CCL4L2/POLR3H/MAVS	0.39708229176849
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/897	73/9376	1.14549258563553	PLCG2/EGFR/AKT2/CDKN1A/E2F3/FOXO3/STAT5B/MAPK3	0.405882497207706
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/897	144/9376	1.08881456707544	C1QB/C1QA/C1QC/CD14/AKT2/TCF7L2/MAPK14/NFKBIA/PRKAG2/C5AR1/TNF/MAP2K7/CXCL3/FOXO3/CAMKK2	0.349322929358093
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/897	105/9376	1.09503636460158	PLCG2/IL1R1/CD14/XIAP/RELB/NFKBIA/NFKB2/TNF/LYN/CXCL3/CCL4L2	0.318515606148669
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/897	75/9376	1.11494611668525	AKT2/XIAP/CDKN1A/SLC31A1/GSTO1/MGST3/MAPK3/REV3L	0.325064583951941
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/897	75/9376	1.11494611668525	CREB3/CREB1/GPX3/PRKACA/CREB3L2/ATP1B3/CANX/ITPR3	0.325064583951941
Organismal Systems	Immune system	hsa04611	Platelet activation	13/897	126/9376	1.07844490453186	PLCG2/F2R/AKT2/APBB1IP/MAPK14/PRKACA/LYN/RASGRP2/COL1A1/ITPR3/MAPK3/PPP1CA/FGG	0.28832923990337
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/897	116/9376	1.08130550109561	MYL9/THY1/PLCG2/ITGAL/MMP2/VCL/ARHGAP5/MAPK14/CYBA/CLDN5/JAM2/AFDN	0.286584682371022
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/897	157/9376	1.06523514332985	C1QB/C1QA/C1QC/RAB7A/MAPKAPK2/CREB1/MAPK14/RAB5C/CRK/MFGE8/AXL/VPS16/TGFBRAP1/VPS18/MAPK3/PTGER4	0.26810139993503
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/897	178/9376	1.05700650107099	NOTUM/DKK1/TCF7L2/PPP3CB/CTBP1/WNT5A/JUN/CREBBP/WNT4/SFRP1/DAAM1/PRKACA/AXIN1/APCDD1/FBXW11/CSNK1E/DVL3/VANGL1	0.24974524394914
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/897	158/9376	1.05849314875182	CDKN1C/HDAC2/YWHAG/CREBBP/CDKN1A/YWHAQ/ORC3/SMC1A/YWHAH/PPP2R1A/CHEK2/E2F3/ANAPC11/MAU2/ZBTB17/ORC6	0.241170805674997
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/897	107/9376	1.07456839516978	AKT2/PPP3CB/CREB3/CREBBP/CREB1/PHKG1/PRKAG2/PRKACA/CREB3L2/PYGB/ITPR3	0.252313092348851
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/897	56/9376	1.11992355470616	MGRN1/SPOP/PRKACA/FBXW11/CSNK1E/IQCE	0.292752149529027
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/897	138/9376	1.0604107088039	PPP3CB/YWHAG/YWHAQ/MAPK14/SMC1A/PRKACA/YWHAH/PPP2R1A/FBXW11/ANAPC11/ITPR3/RPS6KA2/MAPK3/PPP1CA	0.232527347596968
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/897	46/9376	1.13615433086133	FTH1/FTL/UROS/HMOX2/BLVRA	0.301078051131322
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/897	149/9376	1.05227716549572	PLCG2/F2R/PLPP3/EGFR/AKT2/RALA/DGKA/TSC2/AGPAT1/RALGDS/INSR/PLD1/MAPK3/GAB2/PLPP1	0.209210967455164
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/897	16/9376	1.30657748049052	MAOA/GOT2	0.399182836498865
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/897	16/9376	1.30657748049052	HEXB/HEXA	0.399182836498865
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/897	170/9376	1.04526198439242	MYL9/JUN/MYL6/CLDN5/PRKAG2/PRKACA/NF2/PPP2R1A/DLG3/MAP2K7/SYMPK/JAM2/AFDN/TUBA3E/TJP1/SYNPO/TUBA1C	0.193701109371757
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/897	67/9376	1.09206475981298	PPP3CB/CREBBP/PRKACA/ITPR3/RPS6KA2/MAPK3/PPP1CA	0.245973801271454
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/897	98/9376	1.06659386162492	PLCG2/ITPK1/PIK3C2A/PI4KA/SYNJ2/DGKA/INPPL1/PI4K2A/CDIPT/ITPR3	0.215540851990795
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/897	140/9376	1.04526198439242	SERPINE1/SPP1/AKT2/EGR1/GNB5/GNB1/PRKAG2/PRKACA/TGFBR1/SLC9A1/GNG11/GNB2/ITPR3/MAPK3	0.175495178114109
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/897	78/9376	1.07206357373581	ENO2/PARN/EXOSC10/DIS3L/PATL1/EDC3/PABPC4/DHX36	0.207863324089937
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/897	78/9376	1.07206357373581	FN1/CAV1/VCL/ILK/RHOG/CRK/CLTA/CAV2	0.207863324089937
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/897	99/9376	1.05582018625497	MMP2/EGFR/AKT2/JUN/CDKN1A/MAPK14/SP1/PRKACA/E2F3/MAPK3	0.181599497455291
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/897	37/9376	1.13001295609991	HBB/APOA1/TNF/LAMA4	0.257719244389304
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/897	89/9376	1.05700650107099	GABARAP/TRAK2/GNB5/GNB1/PRKACA/GABARAPL1/GNG11/GNB2/SLC38A5	0.175748330609969
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	29/897	298/9376	1.0172012599792	PRL/IL1RL1/PRLR/EBI3/CXCL14/IL1R1/IL1R2/CCL2/RELL1/CSH1/IFNAR1/TNFSF12/IFNAR2/TGFBR1/CCL18/CSF2RB/TNF/IL12RB1/TNFRSF11B/CD4/CXCL3/CCL4L2/GDF15/TNFRSF14/IL21R/IL6ST/INHA/CCL3L1/CCL3	0.0981483142450208
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/897	100/9376	1.04526198439242	CXCL14/CCL2/CCL18/TNF/CXCL3/CCL4L2/TNFRSF14/IL6ST/CCL3L1/CCL3	0.148000356883183
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/897	48/9376	1.08881456707544	ACAA1/HMGCL/ACSF3/MCEE/ACAT1	0.200641190139356
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/897	90/9376	1.04526198439242	EGFR/AKT2/PPP3CB/JUN/MAPK14/NFKBIA/CD4/CD3G/MAPK3	0.140329845698814
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/897	80/9376	1.04526198439242	PLCG2/EGFR/AKT2/KDR/AXL/FOXO3/EIF4EBP1/MAPK3	0.13223306625753
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/897	101/9376	1.03491285583408	TCF7L2/WNT5A/CREB3/CREBBP/WNT4/CREB1/PRKACA/CREB3L2/DVL3/MAPK3	0.114735719898446
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/897	122/9376	1.02812654202533	AKT2/CREB3/CREB1/PRKAG2/TSC2/PPP2R1A/CREB3L2/INSR/FOXO3/IRS2/EIF4EBP1/CAMKK2	0.101704706679574
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/897	70/9376	1.04526198439242	AKT2/NFKBIA/PRKAG2/TNF/IRS2/ACSL1/CAMKK2	0.123626230842247
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/897	39/9376	1.07206357373581	AHCYL1/MTR/GCSH/MTHFR	0.146674278916561
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/897	18/9376	1.16140220488047	HEXB/HEXA	0.22292754709379
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/897	166/9376	1.00748143073968	MYL9/AKT2/PPP3CB/CREB3/CREB1/SRF/ADRA2C/CREB3L2/INSR/ATP2B1/ATP1B3/IRS2/PPIF/ITPR3/MAPK3/PPP1CA	0.0316314012111504
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/897	50/9376	1.04526198439242	CD81/ITGAL/HBB/CCL2/TNF	0.10437114051209
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/897	29/9376	1.08130550109561	NF2/TEAD1/CSNK1E	0.14262391397661
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/897	93/9376	1.01154385586363	FN1/AKT2/XIAP/CDKN1A/NFKBIA/E2F3/LAMA3/LAMA4/ZBTB17	0.036387962348692
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/897	72/9376	1.01622692927041	PIN1/ZNFX1/MAPK14/NFKBIA/IFIH1/TNF/MAVS	0.0449549255346672
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/897	168/9376	0.995487604183256	PRL/PRLR/EGFR/AKT2/STAT6/CSH1/IFNAR1/CREBBP/CDKN1A/IFNAR2/CSF2RB/IL12RB1/STAT5B/PIAS3/IL21R/IL6ST	-0.0191950264801916
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/897	115/9376	0.999815811157966	AKT2/CREB3/GNB5/CREB1/GNB1/PRKACA/CREB3L2/GNG11/GNB2/ITPR3/MAPK3	-0.000646387333848067
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/897	94/9376	1.00078275101402	S100A9/CCL2/JUN/MAPK14/NFKBIA/TNF/CXCL3/MAPK6/MAPK3	0.00248071187587548
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/897	19/9376	1.10027577304465	OGDH/GCSH	0.142302996943363
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/897	212/9376	0.986096211690962	FLT1/F2R/ITGAL/EGFR/AKT2/PRKD2/APBB1IP/KRIT1/MAPK14/RALA/VEGFB/KDR/CRK/RALGDS/INSR/RASGRP2/CNR1/AFDN/MAPK3/RAPGEF1	-0.066599056885581
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/897	63/9376	0.995487604183256	TCF7L2/WNT5A/CDKN1A/WNT4/AXIN1/DVL3	-0.011688053834742
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/897	139/9376	0.977583150870608	KRT18/KRT19/MMP2/EGFR/AKT2/JUN/CREB3/CREB1/SP1/PRKACA/CREB3L2/ITPR3/MAPK3	-0.0866016246207779
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/897	42/9376	0.995487604183256	AOC1/MAOA/KYAT3/ACAT1	-0.0095325145525559
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/897	75/9376	0.975577852099591	IGFBP3/SERPINE1/CDKN1A/EI24/SHISA5/TSC2/CHEK2	-0.0690651896331357
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/897	65/9376	0.964857216362233	PLPP3/MGLL/DGKA/AGPAT1/DGAT1/PLPP1	-0.0924707150249416
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/897	43/9376	0.972336729667367	ACAA1/ECI1/ACSL1/ACAT1	-0.059133918412354
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/897	238/9376	0.966208557001396	FLT1/PLCG2/EGFR/AKT2/GNB5/RAB5C/RALA/VEGFB/GNB1/KDR/PRKACA/RALBP1/RALGDS/GNG11/GNB2/INSR/RASGRP2/PLD1/AFDN/RASA1/MAPK3/GAB2	-0.171743054086761
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/897	143/9376	0.950238167629472	HLA-DRA/C1QB/C1QA/HLA-DRB1/C1QC/HLA-DRB5/C1R/HLA-DQA1/FCGR3A/HLA-DPA1/HLA-DPB1/TNF/C1S	-0.195030487785335
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/897	154/9376	0.950238167629472	TPM1/AKT2/CREB3/TPM2/CREB1/MAPK14/PRKACA/PPP2R1A/SLC9A1/CREB3L2/ATP2B1/ATP1B3/MAPK3/PPP1CA	-0.202513373135163
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/897	122/9376	0.942449330189886	AKT2/PPP3CB/JUN/MAPK14/NFKBIA/PPP2R1A/TNF/MAP2K7/CD4/CD3G/MAPK3	-0.208101443361909
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/897	45/9376	0.929121763904373	ABCB8/ABCC4/ABCA7/ABCD4	-0.155011745004016
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/897	22/9376	0.950238167629472	AOC1/MAOA	-0.0760008699744033
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/897	68/9376	0.922289986228605	CD14/AKT2/TCF7L2/STAT5B/EIF4EBP1/MAPK3	-0.209176454279257
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/897	69/9376	0.90892346468906	CTSB/PPP3CB/CREB1/PRKACA/ITPR3/PTGER4	-0.246965183304274
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/897	125/9376	0.919830546265329	AKT2/SPTSSA/MAPK14/ASAH1/PPP2R1A/TNF/CERS4/SGPP1/PLD1/MAPK3/GAB2	-0.293480420384234
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/897	23/9376	0.90892346468906	RXYLT1/FKRP	-0.142234350508102
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/897	23/9376	0.90892346468906	ICMT/ACAT1	-0.142234350508102
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/897	148/9376	0.918135526831179	EGFR/AKT2/TCF7L2/WNT5A/JUN/CDKN1A/WNT4/SP1/NFKB2/AXIN1/E2F3/DVL3/MAPK3	-0.32649916743289
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/897	47/9376	0.889584667568016	TNF/INSR/IRS2/MAPK3	-0.246814294592264
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/897	104/9376	0.904553640339594	PLPP3/PCYT1A/DGKA/AGPAT1/CHPT1/PLD1/LPCAT1/CDIPT/PLPP1	-0.318345612890873
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/897	59/9376	0.885815241010525	AKT2/MGLL/PRKACA/INSR/IRS2	-0.286157833906562
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	20/897	226/9376	0.925010605657008	MYL9/F2R/FXYD1/AKT2/PDE4A/JUN/CREB3/CREBBP/CREB1/NFKBIA/PRKACA/SLC9A1/CREB3L2/ABCC4/ATP2B1/ATP1B3/PLD1/AFDN/MAPK3/PPP1CA	-0.371153072953432
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/897	36/9376	0.871051653660349	AGL/PYGB/GPI	-0.252117580912767
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/897	216/9376	0.919443412197035	CD14/AKT2/CCL2/PPP3CB/POU2F1/JUN/MAPK14/CYBA/APOA1/MIB2/NFKBIA/TNF/MAP2K7/LYN/NFE2L2/CXCL3/MAPK3/CCL3L1/CCL3	-0.389573801285468
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/897	37/9376	0.847509717074934	COMT/MAOA/GOT2	-0.302275109120339
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/897	12/9376	0.871051653660349	NPC1	-0.14537349766596
NA	NA	hsa04519	Cadherin signaling	36/897	404/9376	0.93142157025067	KRT18/KRT8/KRT19/KRT7/APH1A/VCL/EGFR/TCF7L2/YWHAG/WNT5A/GJA1/CDH11/CREBBP/WNT4/YWHAQ/MAPK14/MYO1G/DSP/DAAM1/NFKBIA/KDR/YWHAH/VIM/NF2/AXIN1/TEAD1/APH1B/LHFPL6/NCSTN/AFDN/DVL3/VANGL1/MAPK3/LIMA1/PPP1CA/TJP1	-0.458292899882546
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/897	38/9376	0.825206829783489	NAPRT/NNMT/NMRK1	-0.351155006647978
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/897	38/9376	0.825206829783489	INSR/ATP1B3/MAPK3	-0.351155006647978
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/897	97/9376	0.862071739705088	GNB5/CREB1/GNB1/PRKACA/GNG11/GNB2/ITPR3/MAPK3	-0.444117698237323
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/897	154/9376	0.882364012798795	MYL9/EGFR/PPP3CB/JUN/MYL6/CDKN1A/PRKAG2/PRKACA/PPP1R12C/ITPR3/MAPK3/PPP1CA/CAMKK2	-0.478737607426011
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/897	26/9376	0.804047680301861	APOA1/ABCD4	-0.325417436593779
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/897	13/9376	0.804047680301861	POLM	-0.229945076791517
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/897	99/9376	0.844656149003975	TPM1/ITGB8/TTN/TPM2/ITGA1/PRKAG2/TNF/EMD	-0.505379275246267
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/897	27/9376	0.774268136586977	HMGCL/ACAT1	-0.382033731959605
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/897	168/9376	0.871051653660349	FTH1/FTL/CHMP4B/VPS4A/XIAP/CHMP1A/STAT6/IFNAR1/CHMP6/IFNAR2/TNF/CHMP3/PYGB/STAT5B	-0.548526109651592
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/897	52/9376	0.804047680301861	CYP11A1/PRKACA/HSD3B1/INSR	-0.460850953665556
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/897	76/9376	0.825206829783489	PLCG2/EGFR/AKT2/CDKN1A/E2F3/MAPK3	-0.497621714451187
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/897	14/9376	0.746615703137442	CHST2	-0.308580826645349
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/897	28/9376	0.746615703137442	FPGS/PTS	-0.436725853741195
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/897	41/9376	0.764825842238355	GRHPR/MAOA/GCSH	-0.490833172746857
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/897	67/9376	0.780046257009268	ENO2/ACSS1/ALDOC/GPI/GAPDH	-0.587660885416113
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/897	116/9376	0.810979125821705	PPP3CB/GNB5/GNB1/PRKACA/GNG11/GNB2/PLD1/ITPR3/MAPK3	-0.666258573625681
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/897	93/9376	0.78675633233838	CST3/LYZ/PRKACA/SLC9A1/ATP2B1/ATP1B3/ITPR3	-0.67217597323041
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/897	105/9376	0.796390083346605	TPM1/ITGB8/TTN/TPM2/ITGA1/PRKACA/TNF/EMD	-0.682401271267234
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/897	201/9376	0.832049340809886	IGFBP3/FLT1/NUPR1/CD14/IL1R2/HDAC2/HPGD/DOT1L/AFF1/PBX3/CDKN1A/MAF/SP1/NR4A3/WT1/ZBTB17	-0.782863864064907
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/897	17/9376	0.61485999081907	TFRC	-0.516937354060139
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/897	71/9376	0.736099989008746	G6PD/EGFR/AKT2/IDH1/MAPK3	-0.725972109149781
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/897	32/9376	0.653288740245262	GALT/GALK1	-0.638978230527508
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/897	32/9376	0.653288740245262	ACSS1/MCEE	-0.638978230527508
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/897	134/9376	0.780046257009268	CALD1/MYL9/RAMP1/ADM/MYL6/PRKACA/PPP1R12C/ITPR3/MAPK3/PPP1CA	-0.834085009623828
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/897	60/9376	0.696841322928279	PPP2R1A/LYN/ITPR3/MAPK3	-0.766196970664022
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/897	73/9376	0.715932866022205	EGFR/AKT2/CDKN1A/E2F3/MAPK3	-0.792465658713188
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/897	47/9376	0.667188500676012	GRHPR/ACSS1/ACAT1	-0.743942291605598
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/897	86/9376	0.729252547250525	CREB3/CREB1/PRKACA/CREB3L2/ATP1B3/ITPR3	-0.820380426745212
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/897	86/9376	0.729252547250525	ITGB8/TCF7L2/GJA1/ITGA1/DSP/EMD	-0.820380426745212
NA	NA	hsa04517	IgSF CAM signaling	24/897	299/9376	0.839006275097594	MYL9/PLCG2/ITGAL/VCL/AKT2/DYNLL2/MYL6/MAPK14/KDR/CLMP/PLXNA3/LYN/TUBB6/TUBB4B/PMP22/PTPRF/JAM2/AFDN/RASA1/MAPK3/TUBA3E/TJP1/TUBA1C/FGG	-0.920201458491285
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/897	195/9376	0.804047680301861	PLCG2/SELPLG/HDAC2/ITGAL/AKT2/MAPK14/FCGR3A/CYBA/CLCN3/HDAC7/GSDMD/C5AR1/PPIF/MAPK3/FGG	-0.899357297915675
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/897	99/9376	0.739074130378478	PLCG2/IL1R1/MAPK14/PRKACA/ITPR3/PPP1CA/PTGER4	-0.848868661597046
NA	NA	hsa04081	Hormone signaling	17/897	219/9376	0.811390581491832	PRL/RAMP1/PRLR/SLC40A1/DIO2/CSH1/GNB5/ADRA2C/GNB1/PRKACA/NPR3/GNG11/GNB2/INSR/IRS2/STAT5B/TRH	-0.918582925478669
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/897	150/9376	0.766525455221107	EGFR/AKT2/TCF7L2/WNT5A/CDKN1A/WNT4/TGFBR1/AXIN1/E2F3/DVL3/MAPK3	-0.937536066479466
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/897	76/9376	0.687672358152907	ACAA1/ILK/PLTP/APOA1/ACSL1	-0.889170992287233
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/897	63/9376	0.663658402788837	PTGDS/HPGD/GPX4/PTGES	-0.871195447988002
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/897	20/9376	0.52263099219621	NSDHL	-0.695078176770387
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/897	20/9376	0.52263099219621	GMPPB	-0.695078176770387
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/897	115/9376	0.727138771751248	GNB5/MAOA/GNB1/PRKACA/GNG11/GNB2/ITPR3/MAPK3	-0.957571804517135
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/897	36/9376	0.580701102440233	FGGY/DCXR	-0.819805966752848
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/897	36/9376	0.580701102440233	GALNT15/GALNT10	-0.819805966752848
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/897	103/9376	0.710372222402615	UPF1/UPF2/CPSF2/PPP2R1A/SYMPK/PABPC4/PPP1CA	-0.961298437378789
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/897	103/9376	0.710372222402615	COL6A3/SLC7A8/COL17A1/ATP1B3/COL1A1/COL6A2/COL5A1	-0.961298437378789
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/897	91/9376	0.689183725973024	PDE4A/GNB5/GNB1/PRKACA/GNG11/GNB2	-0.969042967505427
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/897	21/9376	0.497743802091628	COASY	-0.749415373985608
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/897	65/9376	0.643238144241489	SPP1/AKT2/ITPR3/MAPK3	-0.938742480836412
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/897	37/9376	0.565006478049956	GOT2/ASNS	-0.862269462629982
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/897	191/9376	0.76616061683214	HDAC2/CREB3/GNB5/CREB1/MAOA/HDAC7/GNB1/PRKACA/CREB3L2/GNG11/GNB2/MAPK3/PPP1CA/CAMKK2	-1.06195056946258
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/897	66/9376	0.633492111752981	HSD11B1/COMT/CYP11A1/HSD3B1	-0.971829315743346
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/897	144/9376	0.725876378050291	KAT6A/AKT2/WNT5A/WNT4/MAPK14/RIF1/AXIN1/DVL3/MAPK3/IL6ST	-1.07817523384862
NA	NA	hsa04382	Cornified envelope formation	16/897	217/9376	0.770700080658005	S100A6/KRT18/KRT8/KRT19/KRT7/S100A9/ELOVL1/DSP/CLDN5/PPP2R1A/COL17A1/S100A13/PRSS8/LAMA3/S100A16/TJP1	-1.11152511859153
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/897	217/9376	0.770700080658005	EGFR/AKT2/KPNB1/XIAP/JUN/CREB3/CREB1/PRKACA/KPNA6/GSTO1/CREB3L2/MGST3/STAT5B/RPS6KA2/EIF4EBP1/MAPK3	-1.11152511859153
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/897	133/9376	0.707320139814419	PLCG2/ITGAL/PPP3CB/HLA-G/IFNAR1/FCGR3A/IFNAR2/TNF/MAPK3	-1.10566032270999
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/897	23/9376	0.45446173234453	GOT2	-0.851967863208456
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/897	23/9376	0.45446173234453	ATP6AP2	-0.851967863208456
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/897	23/9376	0.45446173234453	ATP1B3	-0.851967863208456
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/897	184/9376	0.738500315059861	MYL9/PLCG2/ILK/PPP3CB/WNT5A/SEMA3B/WNT4/PLXNA3/SEMA5A/LIMK2/RASA1/MAPK3/SEMA3A	-1.1651574481834
Human Diseases	Infectious disease: viral	hsa05162	Measles	9/897	136/9376	0.691717489671454	AKT2/JUN/IFNAR1/NFKBIA/IFNAR2/IFIH1/CD3G/STAT5B/MAVS	-1.17785518325753
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/897	41/9376	0.50988389482557	BABAM2/POLD2	-1.02292379914003
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/897	85/9376	0.61485999081907	AK3/CANT1/IMPDH2/ENTPD1/NME4	-1.16012934258257
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/897	26/9376	0.40202384015093	ACAA1	-0.993057236485084
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/897	59/9376	0.531489144606315	CANT1/ENTPD1/NME4	-1.17413263142697
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/897	128/9376	0.653288740245262	PDE4A/AK3/PRPS2/PAPSS2/CANT1/IMPDH2/ENTPD1/NME4	-1.28457232818903
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/897	232/9376	0.720870334063737	FN1/MYL9/F2R/ITGAL/ITGB8/VCL/EGFR/AKT2/ITGA1/CRK/DIAPH2/SLC9A1/PPP1R12C/LIMK2/MAPK3/PPP1CA	-1.40020434716085
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/897	76/9376	0.550137886522326	PRKACA/SLC9A1/ATP1B3/ITPR3	-1.28072027012328
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/897	29/9376	0.360435167031869	GNB1	-1.12190735547464
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/897	48/9376	0.435525826830175	AKT2/ATP1B3	-1.27520488628319
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/897	31/9376	0.337181285287877	SMOX	-1.20225197280549
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/897	110/9376	0.570142900577683	AKT2/MAPK14/PRKACA/ANAPC11/RPS6KA2/MAPK3	-1.47497221931604
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/897	32/9376	0.326644370122631	XIAP	-1.2409737981949
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/897	82/9376	0.50988389482557	GSTO1/MGST3/IMPDH2/NME4	-1.44982007133218
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/897	68/9376	0.461144993114303	ALDH1A2/RDH13/DGAT1	-1.45046660321743
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/897	70/9376	0.447969421882465	HSD11B1/GSTO1/MGST3	-1.50778761909006
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/897	54/9376	0.387134068293489	CENPX/REV3L	-1.46898497218101
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/897	102/9376	0.512383325682558	RAB11A/SLC9A1/ATP2B1/ATP1B3/ITPR3	-1.61047738379083
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/897	73/9376	0.429559719613323	MAOA/GSTO1/MGST3	-1.59136442932712
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/897	90/9376	0.464560881952186	PRKACA/SLC9A1/ABCC4/ATP1B3	-1.66007058297124
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/897	38/9376	0.275068943261163	CD4	-1.45636794465786
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/897	79/9376	0.396934930781931	HSD11B1/GSTO1/MGST3	-1.75071658607002
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/897	183/9376	0.514063271012665	WDR43/LSG1/IMP4/RRP7A/FCF1/UTP4/GNL2/REXO1/DROSHA	-2.15916674585177
Genetic Information Processing	Transcription	hsa03040	Spliceosome	13/897	243/9376	0.559193654201706	CTNNBL1/TXNL4A/PRPF4/PUF60/SF1/TCERG1/THOC2/DDX46/XAB2/PQBP1/PRPF6/RP9/HNRNPM	-2.26440334630528
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/897	86/9376	0.243084182416842	PRKACA/ITPR3	-2.29349866502216
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/897	254/9376	0.493824559555474	FLT1/PLCG2/F2R/EGFR/PPP3CB/PHKG1/VEGFB/KDR/PRKACA/ATP2B1/PPIF/ITPR3	-2.66000489529399
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/897	323/9376	0.517776834373954	TIMP3/TPM1/PLCG2/MARCKS/DICER1/HDAC2/EGFR/CREBBP/CDKN1A/CRK/VIM/E2F3/IRS2/ZEB2/MAPK3/TNXB	-2.86855124549908
NA	NA	hsa04082	Neuroactive ligand signaling	7/897	199/9376	0.367680095012409	TAC3/GNB5/ADRA2C/GNB1/PRKACA/GNG11/GNB2	-2.93239565787959
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/897	370/9376	0.395504534634969	PRL/NPW/PRLR/F2R/TAC3/ADM/PGRMC1/CSH1/ADRA2C/C5AR1/RXFP1/CNR1/TRH/PTGER4	-3.85866859254547
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/897	449/9376	0.0465595538704864	GNB1/PRKACA	-6.73400627118423