ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0015453 oxidoreduction-driven active transmembrane transporter activity 26/1692 68/18639 0.382352941176471 4.21198372966208 6.78269043552182e-11 7.96966126173814e-08 GO:0008137 NADH dehydrogenase (ubiquinone) activity 18/1692 41/18639 0.439024390243902 4.83627400103788 4.23163446518984e-09 2.48608524829903e-06 GO:0003954 NADH dehydrogenase activity 18/1692 44/18639 0.409090909090909 4.50652804642166 1.65297232310934e-08 6.4741415988449e-06 GO:0022853 active monoatomic ion transmembrane transporter activity 30/1692 118/18639 0.254237288135593 2.80066714749369 1.48440389297901e-07 4.36043643562585e-05 GO:0015399 primary active transmembrane transporter activity 37/1692 166/18639 0.22289156626506 2.4553640092284 2.194992394317e-07 5.15823212664495e-05 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 19/1692 58/18639 0.327586206896552 3.60867571533382 4.29636835021427e-07 7.29142932368328e-05 GO:0031625 ubiquitin protein ligase binding 55/1692 302/18639 0.182119205298013 2.0062174158095 4.34383023538579e-07 7.29142932368328e-05 GO:0005201 extracellular matrix structural constituent 36/1692 168/18639 0.214285714285714 2.36056231003039 8.74636942695489e-07 0.0001284623009584 GO:0044389 ubiquitin-like protein ligase binding 56/1692 322/18639 0.173913043478261 1.91581868640148 1.57171792996184e-06 0.000205196507522796 GO:0050840 extracellular matrix binding 19/1692 67/18639 0.283582089552239 3.1239282311845 4.94809289018499e-06 0.00054666346868663 GO:0140312 cargo adaptor activity 10/1692 21/18639 0.476190476190476 5.24569402228977 5.11770055791738e-06 0.00054666346868663 GO:0016651 oxidoreductase activity, acting on NAD(P)H 22/1692 88/18639 0.25 2.75398936170213 8.82282253249763e-06 0.000843424323203834 GO:0035615 clathrin adaptor activity 9/1692 18/18639 0.5 5.50797872340426 9.33150315034029e-06 0.000843424323203834 GO:0009055 electron transfer activity 26/1692 116/18639 0.224137931034483 2.46909391049156 1.1992920239499e-05 0.00100654866295795 GO:0005518 collagen binding 19/1692 72/18639 0.263888888888889 2.90698877068558 1.55295639884138e-05 0.00121648251242575 GO:0015078 proton transmembrane transporter activity 35/1692 185/18639 0.189189189189189 2.08410005750431 2.25994016513343e-05 0.00165964355876986 GO:0031994 insulin-like growth factor I binding 7/1692 13/18639 0.538461538461538 5.93166939443535 5.26492500050482e-05 0.00363899227976069 GO:0023026 MHC class II protein complex binding 10/1692 27/18639 0.37037037037037 4.07998423955871 7.36230972140201e-05 0.00471449339983496 GO:0002020 protease binding 27/1692 136/18639 0.198529411764706 2.18699155193992 8.02466961674037e-05 0.00471449339983496 GO:0019838 growth factor binding 27/1692 136/18639 0.198529411764706 2.18699155193992 8.02466961674037e-05 0.00471449339983496 GO:0003735 structural constituent of ribosome 32/1692 175/18639 0.182857142857143 2.01434650455927 9.80658345698237e-05 0.00548701693426394 GO:0005543 phospholipid binding 70/1692 497/18639 0.140845070422535 1.5515433023674 0.000142612659455254 0.00761681249363291 GO:0001968 fibronectin binding 10/1692 30/18639 0.333333333333333 3.67198581560284 0.000203557924077461 0.0103991548170007 GO:0042277 peptide binding 40/1692 249/18639 0.160642570281124 1.76963171836281 0.000270961034085507 0.0129822001007244 GO:0070325 lipoprotein particle receptor binding 10/1692 31/18639 0.32258064516129 3.55353466026081 0.000276217023419668 0.0129822001007244 GO:0050750 low-density lipoprotein particle receptor binding 9/1692 26/18639 0.346153846153846 3.81321603927987 0.000306783853318404 0.0131617652078765 GO:0061134 peptidase regulator activity 37/1692 226/18639 0.163716814159292 1.80349745810582 0.000309278493165602 0.0131617652078765 GO:0035091 phosphatidylinositol binding 44/1692 284/18639 0.154929577464789 1.70669763260414 0.000313642064528121 0.0131617652078765 GO:0016504 peptidase activator activity 14/1692 57/18639 0.245614035087719 2.70567375886525 0.000448338604202561 0.0177668601189029 GO:0061133 endopeptidase activator activity 8/1692 22/18639 0.363636363636364 4.00580270793037 0.000453621960482629 0.0177668601189029 GO:0045296 cadherin binding 49/1692 334/18639 0.146706586826347 1.61611351764556 0.000539988752234487 0.0204583912237919 GO:0061135 endopeptidase regulator activity 31/1692 184/18639 0.168478260869565 1.85594935245143 0.000557164697158588 0.0204583912237919 GO:0031593 polyubiquitin modification-dependent protein binding 14/1692 59/18639 0.23728813559322 2.61395600432744 0.000652452333174956 0.0232312573175931 GO:0043495 protein-membrane adaptor activity 12/1692 47/18639 0.25531914893617 2.81258488003622 0.0007769439271492 0.0268502680705974 GO:0140030 modification-dependent protein binding 29/1692 173/18639 0.167630057803468 1.84660558356906 0.000896721723075027 0.0301042292746616 GO:0005520 insulin-like growth factor binding 7/1692 19/18639 0.368421052631579 4.05851063829787 0.000948525403311719 0.0309588152469797 GO:0140313 molecular sequestering activity 13/1692 55/18639 0.236363636363636 2.60377176015474 0.00104616181906536 0.0332227064162647 GO:0032182 ubiquitin-like protein binding 22/1692 120/18639 0.183333333333333 2.01959219858156 0.00109301913267533 0.0337973021287767 GO:0043021 ribonucleoprotein complex binding 29/1692 177/18639 0.163841807909605 1.80487438394038 0.0012956311309612 0.0375716228336143 GO:0023023 MHC protein complex binding 10/1692 37/18639 0.27027027027027 2.97728579643473 0.00131100981802399 0.0375716228336143 GO:0043394 proteoglycan binding 10/1692 37/18639 0.27027027027027 2.97728579643473 0.00131100981802399 0.0375716228336143 GO:0043130 ubiquitin binding 19/1692 100/18639 0.19 2.09303191489362 0.00150328139973932 0.0420560867784213 GO:0120015 sterol transfer activity 9/1692 32/18639 0.28125 3.09823803191489 0.00167236360223546 0.0456983077355038 GO:0019843 rRNA binding 14/1692 65/18639 0.215384615384615 2.37266775777414 0.00178893707469707 0.0477727514265694 GO:0140416 transcription regulator inhibitor activity 9/1692 33/18639 0.272727272727273 3.00435203094778 0.00211679864293013 0.055271964565398 GO:0016407 acetyltransferase activity 18/1692 96/18639 0.1875 2.0654920212766 0.00230289316010071 0.0588239013721378 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/1692 22/18639 0.318181818181818 3.50507736943907 0.00251914383002307 0.0629785957505768 GO:0005178 integrin binding 26/1692 161/18639 0.161490683229814 1.77897449451566 0.00275190026796724 0.0644016077360782 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/1692 12/18639 0.416666666666667 4.58998226950355 0.00281550846628356 0.0644016077360782 GO:0035259 nuclear glucocorticoid receptor binding 5/1692 12/18639 0.416666666666667 4.58998226950355 0.00281550846628356 0.0644016077360782 GO:0032977 membrane insertase activity 6/1692 17/18639 0.352941176470588 3.88798498122653 0.00285011370406474 0.0644016077360782 GO:0048038 quinone binding 6/1692 17/18639 0.352941176470588 3.88798498122653 0.00285011370406474 0.0644016077360782 GO:0051117 ATPase binding 16/1692 84/18639 0.19047619047619 2.09827760891591 0.00333692983202843 0.073979104766668 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 47/1692 349/18639 0.134670487106017 1.48352435530086 0.00403537378647426 0.087806744427912 GO:0051020 GTPase binding 43/1692 315/18639 0.136507936507936 1.50376561972307 0.00452770996281483 0.0967283492055895 GO:1901981 phosphatidylinositol phosphate binding 28/1692 185/18639 0.151351351351351 1.66728004600345 0.00497984064098755 0.104487727735007 GO:0005048 signal sequence binding 11/1692 51/18639 0.215686274509804 2.37599082186066 0.00529504921140402 0.109152330235083 GO:0003713 transcription coactivator activity 36/1692 256/18639 0.140625 1.54911901595745 0.00554331390747089 0.109249014781432 GO:0019211 phosphatase activator activity 7/1692 25/18639 0.28 3.08446808510638 0.00557867309522204 0.109249014781432 GO:0120020 cholesterol transfer activity 7/1692 25/18639 0.28 3.08446808510638 0.00557867309522204 0.109249014781432 GO:0016922 nuclear receptor binding 22/1692 137/18639 0.160583941605839 1.76898586737071 0.00597122736943489 0.113405514083069 GO:0004065 arylsulfatase activity 5/1692 14/18639 0.357142857142857 3.93427051671733 0.00610159108309855 0.113405514083069 GO:0008191 metalloendopeptidase inhibitor activity 5/1692 14/18639 0.357142857142857 3.93427051671733 0.00610159108309855 0.113405514083069 GO:0030159 signaling receptor complex adaptor activity 11/1692 52/18639 0.211538461538462 2.33029869067103 0.00617698119260969 0.113405514083069 GO:0001540 amyloid-beta binding 15/1692 83/18639 0.180722891566265 1.99083568315816 0.00729219562859291 0.131034043464984 GO:0004857 enzyme inhibitor activity 53/1692 416/18639 0.127403846153846 1.40347534779051 0.00736021010101188 0.131034043464984 GO:0004177 aminopeptidase activity 9/1692 40/18639 0.225 2.47859042553192 0.00843206728411575 0.144355770182557 GO:0051371 muscle alpha-actinin binding 5/1692 15/18639 0.333333333333333 3.67198581560284 0.00847706224901824 0.144355770182557 GO:0120283 protein serine/threonine kinase binding 5/1692 15/18639 0.333333333333333 3.67198581560284 0.00847706224901824 0.144355770182557 GO:0032395 MHC class II receptor activity 4/1692 10/18639 0.4 4.4063829787234 0.00908612940051513 0.152517172080075 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 32/1692 229/18639 0.139737991266376 1.53934776549289 0.00935999239476775 0.154901282589466 GO:0097110 scaffold protein binding 13/1692 70/18639 0.185714285714286 2.04582066869301 0.00958128688804624 0.155152076424408 GO:0140297 DNA-binding transcription factor binding 60/1692 488/18639 0.122950819672131 1.35442099755842 0.00963923538636749 0.155152076424408 GO:0016410 N-acyltransferase activity 16/1692 94/18639 0.170212765957447 1.87505658669081 0.0101757152730641 0.161573857376355 GO:0003779 actin binding 55/1692 443/18639 0.124153498871332 1.36766966043898 0.0106353508451705 0.166620496574338 GO:0016881 acid-amino acid ligase activity 6/1692 22/18639 0.272727272727273 3.00435203094778 0.0115943927203482 0.179255413768542 GO:0038024 cargo receptor activity 12/1692 65/18639 0.184615384615385 2.03371522094926 0.013121162722863 0.194819412193438 GO:0019107 myristoyltransferase activity 4/1692 11/18639 0.363636363636364 4.00580270793037 0.0132643004046596 0.194819412193438 GO:0048185 activin binding 4/1692 11/18639 0.363636363636364 4.00580270793037 0.0132643004046596 0.194819412193438 GO:0140031 phosphorylation-dependent protein binding 4/1692 11/18639 0.363636363636364 4.00580270793037 0.0132643004046596 0.194819412193438 GO:0008484 sulfuric ester hydrolase activity 5/1692 17/18639 0.294117647058824 3.23998748435544 0.0149949234860454 0.217518951803746 GO:0001221 transcription coregulator binding 18/1692 115/18639 0.156521739130435 1.72423681776133 0.0155405631561754 0.22268489888422 GO:0003725 double-stranded RNA binding 13/1692 75/18639 0.173333333333333 1.90943262411348 0.0167796613306657 0.233593744508289 GO:0043998 histone H2A acetyltransferase activity 6/1692 24/18639 0.25 2.75398936170213 0.017892355809071 0.233593744508289 GO:0050431 transforming growth factor beta binding 6/1692 24/18639 0.25 2.75398936170213 0.017892355809071 0.233593744508289 GO:0070300 phosphatidic acid binding 6/1692 24/18639 0.25 2.75398936170213 0.017892355809071 0.233593744508289 GO:0042605 peptide antigen binding 9/1692 45/18639 0.2 2.2031914893617 0.0181636974912933 0.233593744508289 GO:0046915 transition metal ion transmembrane transporter activity 9/1692 45/18639 0.2 2.2031914893617 0.0181636974912933 0.233593744508289 GO:0051539 4 iron, 4 sulfur cluster binding 9/1692 45/18639 0.2 2.2031914893617 0.0181636974912933 0.233593744508289 GO:0019208 phosphatase regulator activity 18/1692 117/18639 0.153846153846154 1.69476268412439 0.0183162304145837 0.233593744508289 GO:0003712 transcription coregulator activity 59/1692 495/18639 0.119191919191919 1.31301310982162 0.0184784524699397 0.233593744508289 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/1692 12/18639 0.333333333333333 3.67198581560284 0.0184886963738475 0.233593744508289 GO:0035497 cAMP response element binding 4/1692 12/18639 0.333333333333333 3.67198581560284 0.0184886963738475 0.233593744508289 GO:0034212 protein N-acetyltransferase activity 10/1692 53/18639 0.188679245283019 2.07848253713368 0.0194733226248684 0.241724775238305 GO:0004866 endopeptidase inhibitor activity 23/1692 161/18639 0.142857142857143 1.57370820668693 0.0195437052320332 0.241724775238305 GO:0005539 glycosaminoglycan binding 32/1692 242/18639 0.132231404958678 1.4566555301565 0.0198187192618719 0.242572865965619 GO:0019955 cytokine binding 21/1692 144/18639 0.145833333333333 1.60649379432624 0.0201843380940239 0.244501002685342 GO:0008080 N-acetyltransferase activity 12/1692 69/18639 0.173913043478261 1.91581868640148 0.0205658984098409 0.246580924811867 GO:0030276 clathrin binding 9/1692 46/18639 0.195652173913043 2.15529602220167 0.0208180123982413 0.247082470383166 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/1692 25/18639 0.24 2.64382978723404 0.0217808871923917 0.255925424510603 GO:0015485 cholesterol binding 10/1692 54/18639 0.185185185185185 2.03999211977935 0.0220164504105156 0.256131972597582 GO:1902936 phosphatidylinositol bisphosphate binding 17/1692 111/18639 0.153153153153153 1.68712861797968 0.0223217705694758 0.257138043324844 GO:0061733 protein-lysine-acetyltransferase activity 9/1692 47/18639 0.191489361702128 2.10943866002716 0.0237402856271567 0.269902969744702 GO:0008276 protein methyltransferase activity 15/1692 95/18639 0.157894736842105 1.73936170212766 0.0238892841305949 0.269902969744702 GO:0043022 ribosome binding 17/1692 112/18639 0.151785714285714 1.67206496960486 0.0241679790518076 0.27045119415118 GO:0046332 SMAD binding 13/1692 79/18639 0.164556962025316 1.81275249124697 0.0250209871032932 0.2745927698888 GO:0140375 immune receptor activity 22/1692 156/18639 0.141025641025641 1.55353246044735 0.0251419507970194 0.2745927698888 GO:0050997 quaternary ammonium group binding 8/1692 40/18639 0.2 2.2031914893617 0.0252391652323322 0.2745927698888 GO:0042393 histone binding 32/1692 247/18639 0.129554655870445 1.42716857610475 0.0257268616105739 0.275176982517924 GO:0004896 cytokine receptor activity 15/1692 96/18639 0.15625 1.72124335106383 0.0260207263172 0.275176982517924 GO:0008157 protein phosphatase 1 binding 6/1692 26/18639 0.230769230769231 2.54214402618658 0.0262012871102528 0.275176982517924 GO:0140311 protein sequestering activity 7/1692 33/18639 0.212121212121212 2.33671824629271 0.0262296357804319 0.275176982517924 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/1692 48/18639 0.1875 2.0654920212766 0.0269432040967817 0.276304858562961 GO:0032266 phosphatidylinositol-3-phosphate binding 9/1692 48/18639 0.1875 2.0654920212766 0.0269432040967817 0.276304858562961 GO:0022804 active transmembrane transporter activity 54/1692 457/18639 0.118161925601751 1.30166674426184 0.0270426031785025 0.276304858562961 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/1692 20/18639 0.25 2.75398936170213 0.0299309380286542 0.29929395420198 GO:0043024 ribosomal small subunit binding 5/1692 20/18639 0.25 2.75398936170213 0.0299309380286542 0.29929395420198 GO:0008168 methyltransferase activity 27/1692 204/18639 0.132352941176471 1.45799436795995 0.0300567545496457 0.29929395420198 GO:0120013 lipid transfer activity 11/1692 65/18639 0.169230769230769 1.86423895253683 0.0311292492140012 0.304040858541742 GO:0005385 zinc ion transmembrane transporter activity 6/1692 27/18639 0.222222222222222 2.44799054373522 0.0311784199504605 0.304040858541742 GO:0005545 1-phosphatidylinositol binding 4/1692 14/18639 0.285714285714286 3.14741641337386 0.0323119882781543 0.304040858541742 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 4/1692 14/18639 0.285714285714286 3.14741641337386 0.0323119882781543 0.304040858541742 GO:0044548 S100 protein binding 4/1692 14/18639 0.285714285714286 3.14741641337386 0.0323119882781543 0.304040858541742 GO:0030414 peptidase inhibitor activity 23/1692 169/18639 0.136094674556213 1.4992131436485 0.0323979369522754 0.304040858541742 GO:0004402 histone acetyltransferase activity 8/1692 42/18639 0.19047619047619 2.09827760891591 0.0330085388326306 0.304040858541742 GO:0048487 beta-tubulin binding 8/1692 42/18639 0.19047619047619 2.09827760891591 0.0330085388326306 0.304040858541742 GO:0051879 Hsp90 protein binding 8/1692 42/18639 0.19047619047619 2.09827760891591 0.0330085388326306 0.304040858541742 GO:0016741 transferase activity, transferring one-carbon groups 28/1692 215/18639 0.130232558139535 1.43463631865413 0.0331210467177388 0.304040858541742 GO:0051087 protein-folding chaperone binding 19/1692 134/18639 0.141791044776119 1.56196411559225 0.0338563234146677 0.308381240404919 GO:0010485 histone H4 acetyltransferase activity 7/1692 35/18639 0.2 2.2031914893617 0.035268278421373 0.313384685648788 GO:0140098 catalytic activity, acting on RNA 46/1692 387/18639 0.118863049095607 1.30939029083512 0.035564538212941 0.313384685648788 GO:0072542 protein phosphatase activator activity 5/1692 21/18639 0.238095238095238 2.62284701114488 0.0364345671497435 0.313384685648788 GO:0019789 SUMO transferase activity 6/1692 28/18639 0.214285714285714 2.36056231003039 0.0367333885490201 0.313384685648788 GO:0036408 histone H3K14 acetyltransferase activity 6/1692 28/18639 0.214285714285714 2.36056231003039 0.0367333885490201 0.313384685648788 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/1692 28/18639 0.214285714285714 2.36056231003039 0.0367333885490201 0.313384685648788 GO:0031267 small GTPase binding 35/1692 283/18639 0.123674911660777 1.36239756409293 0.0374255325111726 0.313384685648788 GO:0042054 histone methyltransferase activity 11/1692 67/18639 0.164179104477612 1.8085900285805 0.037916095794873 0.313384685648788 GO:0019902 phosphatase binding 25/1692 190/18639 0.131578947368421 1.44946808510638 0.0380012749025461 0.313384685648788 GO:0003743 translation initiation factor activity 9/1692 51/18639 0.176470588235294 1.94399249061327 0.0383517668007456 0.313384685648788 GO:0008201 heparin binding 23/1692 172/18639 0.133720930232558 1.47306407718951 0.0385816348436369 0.313384685648788 GO:1901681 sulfur compound binding 34/1692 275/18639 0.123636363636364 1.36197292069632 0.0399232817991718 0.313384685648788 GO:0004129 cytochrome-c oxidase activity 4/1692 15/18639 0.266666666666667 2.93758865248227 0.0409792341069309 0.313384685648788 GO:0010181 FMN binding 4/1692 15/18639 0.266666666666667 2.93758865248227 0.0409792341069309 0.313384685648788 GO:0032934 sterol binding 11/1692 68/18639 0.161764705882353 1.78199311639549 0.0416697171471066 0.313384685648788 GO:0140223 general transcription initiation factor activity 11/1692 68/18639 0.161764705882353 1.78199311639549 0.0416697171471066 0.313384685648788 GO:0008238 exopeptidase activity 15/1692 102/18639 0.147058823529412 1.61999374217772 0.0418721645833698 0.313384685648788 GO:0005080 protein kinase C binding 9/1692 52/18639 0.173076923076923 1.90660801963993 0.0427889339328166 0.313384685648788 GO:0010484 histone H3 acetyltransferase activity 6/1692 29/18639 0.206896551724138 2.27916360968452 0.0428833270352763 0.313384685648788 GO:0043236 laminin binding 6/1692 29/18639 0.206896551724138 2.27916360968452 0.0428833270352763 0.313384685648788 GO:0032931 histone H3K56 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0034062 5'-3' RNA polymerase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0043992 histone H3K9 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0043993 histone H3K18 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0043994 histone H3K23 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0043999 histone H2AK5 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044012 histone H2AK9 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044014 histone H2BK5 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044015 histone H2BK12 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044016 histone H3K4 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044017 histone H3K27 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0044018 histone H3K36 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0046972 histone H4K16 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0097747 RNA polymerase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0140908 histone H3K122 acetyltransferase activity 5/1692 22/18639 0.227272727272727 2.50362669245648 0.0437405008054479 0.313384685648788 GO:0016251 RNA polymerase II general transcription initiation factor activity 9/1692 53/18639 0.169811320754717 1.87063428342031 0.047558036245806 0.337439677188342 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 22/1692 167/18639 0.131736526946108 1.45120397502867 0.048638386186706 0.337439677188342 GO:0031072 heat shock protein binding 18/1692 131/18639 0.137404580152672 1.51364300795842 0.0495998296942545 0.337439677188342 GO:0031210 phosphatidylcholine binding 6/1692 30/18639 0.2 2.2031914893617 0.0496412645449049 0.337439677188342 GO:0043995 histone H4K5 acetyltransferase activity 6/1692 30/18639 0.2 2.2031914893617 0.0496412645449049 0.337439677188342 GO:0043996 histone H4K8 acetyltransferase activity 6/1692 30/18639 0.2 2.2031914893617 0.0496412645449049 0.337439677188342 GO:0043997 histone H4K12 acetyltransferase activity 6/1692 30/18639 0.2 2.2031914893617 0.0496412645449049 0.337439677188342 GO:0004707 MAP kinase activity 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0005159 insulin-like growth factor receptor binding 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0005521 lamin binding 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0016722 oxidoreductase activity, acting on metal ions 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0034450 ubiquitin-ubiquitin ligase activity 4/1692 16/18639 0.25 2.75398936170213 0.0508313386062438 0.337439677188342 GO:0003887 DNA-directed DNA polymerase activity 5/1692 23/18639 0.217391304347826 2.39477335800185 0.0518608210903839 0.338535915451117 GO:0008171 O-methyltransferase activity 5/1692 23/18639 0.217391304347826 2.39477335800185 0.0518608210903839 0.338535915451117 GO:0044013 histone H2B acetyltransferase activity 5/1692 23/18639 0.217391304347826 2.39477335800185 0.0518608210903839 0.338535915451117 GO:0050661 NADP binding 9/1692 54/18639 0.166666666666667 1.83599290780142 0.0526663534128641 0.340016292637996 GO:0051287 NAD binding 9/1692 54/18639 0.166666666666667 1.83599290780142 0.0526663534128641 0.340016292637996 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1692 46/18639 0.173913043478261 1.91581868640148 0.0530827547647648 0.340831895347533 GO:0004382 GDP phosphatase activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0008190 eukaryotic initiation factor 4E binding 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0140999 histone H3K4 trimethyltransferase activity 3/1692 10/18639 0.3 3.30478723404255 0.0551696981608506 0.341181028099997 GO:0061659 ubiquitin-like protein ligase activity 43/1692 372/18639 0.115591397849462 1.27334991992679 0.0594018645421049 0.361713550288257 GO:0019888 protein phosphatase regulator activity 15/1692 107/18639 0.14018691588785 1.54429310001988 0.0595495744570767 0.361713550288257 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/1692 24/18639 0.208333333333333 2.29499113475177 0.0607998909012555 0.361713550288257 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/1692 24/18639 0.208333333333333 2.29499113475177 0.0607998909012555 0.361713550288257 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/1692 24/18639 0.208333333333333 2.29499113475177 0.0607998909012555 0.361713550288257 GO:0033218 amide binding 30/1692 247/18639 0.121457489878543 1.3379705400982 0.0616670657206244 0.361713550288257 GO:0008429 phosphatidylethanolamine binding 4/1692 17/18639 0.235294117647059 2.59198998748436 0.0618579278739972 0.361713550288257 GO:0017110 nucleoside diphosphate phosphatase activity 4/1692 17/18639 0.235294117647059 2.59198998748436 0.0618579278739972 0.361713550288257 GO:0032183 SUMO binding 4/1692 17/18639 0.235294117647059 2.59198998748436 0.0618579278739972 0.361713550288257 GO:0046965 nuclear retinoid X receptor binding 4/1692 17/18639 0.235294117647059 2.59198998748436 0.0618579278739972 0.361713550288257 GO:0003774 cytoskeletal motor activity 20/1692 153/18639 0.130718954248366 1.43999443749131 0.0618761051982465 0.361713550288257 GO:0019903 protein phosphatase binding 19/1692 144/18639 0.131944444444444 1.45349438534279 0.0625584468430816 0.363891955646638 GO:0031369 translation initiation factor binding 6/1692 32/18639 0.1875 2.0654920212766 0.0650123742090948 0.375437019799194 GO:0140693 molecular condensate scaffold activity 8/1692 48/18639 0.166666666666667 1.83599290780142 0.0655334265322341 0.375437019799194 GO:0019207 kinase regulator activity 34/1692 287/18639 0.118466898954704 1.30502631774038 0.0655417736368207 0.375437019799194 GO:0061791 GTPase motor activity 7/1692 40/18639 0.175 1.92779255319149 0.066140819658241 0.375437019799194 GO:1990606 membrane scission GTPase motor activity 7/1692 40/18639 0.175 1.92779255319149 0.066140819658241 0.375437019799194 GO:0016779 nucleotidyltransferase activity 18/1692 136/18639 0.132352941176471 1.45799436795995 0.0668465106677667 0.377618509781855 GO:0016755 aminoacyltransferase activity 55/1692 496/18639 0.110887096774194 1.22152753946465 0.0696758985491787 0.383820097812539 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/1692 25/18639 0.2 2.2031914893617 0.0705546418284714 0.383820097812539 GO:0019707 protein-cysteine S-acyltransferase activity 5/1692 25/18639 0.2 2.2031914893617 0.0705546418284714 0.383820097812539 GO:0005114 type II transforming growth factor beta receptor binding 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0008199 ferric iron binding 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0008526 phosphatidylinositol transfer activity 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0032050 clathrin heavy chain binding 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0042608 T cell receptor binding 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0097493 structural molecule activity conferring elasticity 3/1692 11/18639 0.272727272727273 3.00435203094778 0.0708842223194221 0.383820097812539 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/1692 41/18639 0.170731707317073 1.88077322262584 0.0737988437783214 0.391844856465366 GO:0070628 proteasome binding 4/1692 18/18639 0.222222222222222 2.44799054373522 0.0740336664981373 0.391844856465366 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1692 18/18639 0.222222222222222 2.44799054373522 0.0740336664981373 0.391844856465366 GO:1901611 phosphatidylglycerol binding 4/1692 18/18639 0.222222222222222 2.44799054373522 0.0740336664981373 0.391844856465366 GO:1990381 ubiquitin-specific protease binding 4/1692 18/18639 0.222222222222222 2.44799054373522 0.0740336664981373 0.391844856465366 GO:0035591 signaling adaptor activity 17/1692 129/18639 0.131782945736434 1.45171532244763 0.0756681785851201 0.398632308953608 GO:0019787 ubiquitin-like protein transferase activity 53/1692 479/18639 0.110647181628392 1.21888464442766 0.0759945848558368 0.398632308953608 GO:0051536 iron-sulfur cluster binding 11/1692 76/18639 0.144736842105263 1.59441489361702 0.0810682064841911 0.414391665856536 GO:0005160 transforming growth factor beta receptor binding 5/1692 26/18639 0.192307692307692 2.11845335515548 0.0811149643804283 0.414391665856536 GO:0008198 ferrous iron binding 5/1692 26/18639 0.192307692307692 2.11845335515548 0.0811149643804283 0.414391665856536 GO:0050681 nuclear androgen receptor binding 5/1692 26/18639 0.192307692307692 2.11845335515548 0.0811149643804283 0.414391665856536 GO:0070006 metalloaminopeptidase activity 5/1692 26/18639 0.192307692307692 2.11845335515548 0.0811149643804283 0.414391665856536 GO:0070412 R-SMAD binding 5/1692 26/18639 0.192307692307692 2.11845335515548 0.0811149643804283 0.414391665856536 GO:0008307 structural constituent of muscle 7/1692 42/18639 0.166666666666667 1.83599290780142 0.0819569047674595 0.415083461645538 GO:0019894 kinesin binding 7/1692 42/18639 0.166666666666667 1.83599290780142 0.0819569047674595 0.415083461645538 GO:0070063 RNA polymerase binding 9/1692 59/18639 0.152542372881356 1.68040028849621 0.0834693015207248 0.420928881059449 GO:0061630 ubiquitin protein ligase activity 40/1692 353/18639 0.113314447592068 1.24826713278283 0.0846351098686483 0.424983991861803 GO:0051540 metal cluster binding 11/1692 77/18639 0.142857142857143 1.57370820668693 0.0872180152209891 0.432543925919463 GO:0042577 lipid phosphatase activity 4/1692 19/18639 0.210526315789474 2.31914893617021 0.0873200710170716 0.432543925919463 GO:0042800 histone H3K4 methyltransferase activity 4/1692 19/18639 0.210526315789474 2.31914893617021 0.0873200710170716 0.432543925919463 GO:0016209 antioxidant activity 12/1692 86/18639 0.13953488372093 1.53711034141514 0.0878141387727266 0.432543925919463 GO:0008603 cAMP-dependent protein kinase regulator activity 3/1692 12/18639 0.25 2.75398936170213 0.0883493976346137 0.432543925919463 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/1692 12/18639 0.25 2.75398936170213 0.0883493976346137 0.432543925919463 GO:0008375 acetylglucosaminyltransferase activity 7/1692 43/18639 0.162790697674419 1.79329539831766 0.090612278323572 0.436771100549329 GO:0048156 tau protein binding 7/1692 43/18639 0.162790697674419 1.79329539831766 0.090612278323572 0.436771100549329 GO:0001098 basal transcription machinery binding 9/1692 60/18639 0.15 1.65239361702128 0.0906997008800309 0.436771100549329 GO:0001099 basal RNA polymerase II transcription machinery binding 9/1692 60/18639 0.15 1.65239361702128 0.0906997008800309 0.436771100549329 GO:0016279 protein-lysine N-methyltransferase activity 10/1692 69/18639 0.144927536231884 1.59651557200123 0.0926724799139555 0.44444964856693 GO:0016278 lysine N-methyltransferase activity 10/1692 70/18639 0.142857142857143 1.57370820668693 0.0997963473465955 0.476669545253048 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/1692 36/18639 0.166666666666667 1.83599290780142 0.103164160354239 0.482939794486975 GO:0016409 palmitoyltransferase activity 6/1692 36/18639 0.166666666666667 1.83599290780142 0.103164160354239 0.482939794486975 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 6/1692 36/18639 0.166666666666667 1.83599290780142 0.103164160354239 0.482939794486975 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 6/1692 36/18639 0.166666666666667 1.83599290780142 0.103164160354239 0.482939794486975 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 6/1692 36/18639 0.166666666666667 1.83599290780142 0.103164160354239 0.482939794486975 GO:0051393 alpha-actinin binding 5/1692 28/18639 0.178571428571429 1.96713525835866 0.104579568257208 0.487622986913568 GO:0008170 N-methyltransferase activity 13/1692 98/18639 0.13265306122449 1.46130047763786 0.105785514104947 0.491296359973566 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/1692 13/18639 0.230769230769231 2.54214402618658 0.107407225915413 0.492982384572699 GO:0008035 high-density lipoprotein particle binding 3/1692 13/18639 0.230769230769231 2.54214402618658 0.107407225915413 0.492982384572699 GO:0030955 potassium ion binding 3/1692 13/18639 0.230769230769231 2.54214402618658 0.107407225915413 0.492982384572699 GO:0140463 chromatin-protein adaptor activity 8/1692 54/18639 0.148148148148148 1.63199369582348 0.112854336797549 0.515968271350664 GO:0003714 transcription corepressor activity 24/1692 204/18639 0.117647058823529 1.29599499374218 0.113504413864261 0.516929016629871 GO:0042805 actinin binding 6/1692 37/18639 0.162162162162162 1.78637147786084 0.114197977761352 0.518079628840109 GO:0051010 microtubule plus-end binding 4/1692 21/18639 0.19047619047619 2.09827760891591 0.117016245349925 0.520693277049073 GO:1904047 S-adenosyl-L-methionine binding 4/1692 21/18639 0.19047619047619 2.09827760891591 0.117016245349925 0.520693277049073 GO:0016417 S-acyltransferase activity 5/1692 29/18639 0.172413793103448 1.89930300807043 0.11743295184511 0.520693277049073 GO:0035250 UDP-galactosyltransferase activity 5/1692 29/18639 0.172413793103448 1.89930300807043 0.11743295184511 0.520693277049073 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/1692 29/18639 0.172413793103448 1.89930300807043 0.11743295184511 0.520693277049073 GO:0051861 glycolipid binding 5/1692 29/18639 0.172413793103448 1.89930300807043 0.11743295184511 0.520693277049073 GO:0072341 modified amino acid binding 12/1692 91/18639 0.131868131868132 1.45265372924947 0.12068235795264 0.533089363136663 GO:0019887 protein kinase regulator activity 29/1692 255/18639 0.113725490196078 1.25279516061744 0.121818145569654 0.536091090053719 GO:0008234 cysteine-type peptidase activity 22/1692 187/18639 0.117647058823529 1.29599499374218 0.125284692099505 0.540984571258058 GO:0042162 telomeric DNA binding 6/1692 38/18639 0.157894736842105 1.73936170212766 0.12579951597729 0.540984571258058 GO:0004705 JUN kinase activity 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0008494 translation activator activity 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0019992 diacylglycerol binding 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0046030 inositol trisphosphate phosphatase activity 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0061665 SUMO ligase activity 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0071933 Arp2/3 complex binding 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:1901612 cardiolipin binding 3/1692 14/18639 0.214285714285714 2.36056231003039 0.12788774527103 0.540984571258058 GO:0043178 alcohol binding 12/1692 92/18639 0.130434782608696 1.43686401480111 0.127994647497651 0.540984571258058 GO:0008135 translation factor activity, RNA binding 11/1692 83/18639 0.132530120481928 1.45994616764932 0.129914392683434 0.547130506820912 GO:0140597 protein carrier chaperone 22/1692 188/18639 0.117021276595745 1.28910140334993 0.130387661612205 0.547162508551218 GO:0048029 monosaccharide binding 10/1692 74/18639 0.135135135135135 1.48864289821737 0.131367021868694 0.549310500696497 GO:0004842 ubiquitin-protein transferase activity 48/1692 449/18639 0.106904231625835 1.17765246647396 0.132105924604742 0.550441352519757 GO:0005525 GTP binding 41/1692 378/18639 0.108465608465608 1.19485252729934 0.132578143094487 0.550456954544249 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4/1692 22/18639 0.181818181818182 2.00290135396518 0.133299744137586 0.55150422310445 GO:0019842 vitamin binding 18/1692 150/18639 0.12 1.32191489361702 0.135092275558795 0.55695938168977 GO:0005200 structural constituent of cytoskeleton 14/1692 112/18639 0.125 1.37699468085106 0.136893323254353 0.560241872782259 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/1692 39/18639 0.153846153846154 1.69476268412439 0.137947967948851 0.560241872782259 GO:0004860 protein kinase inhibitor activity 11/1692 84/18639 0.130952380952381 1.44256585612969 0.13797673621586 0.560241872782259 GO:0180051 translation factor activity 11/1692 84/18639 0.130952380952381 1.44256585612969 0.13797673621586 0.560241872782259 GO:0019001 guanyl nucleotide binding 43/1692 400/18639 0.1075 1.18421542553191 0.138796846809185 0.560241872782259 GO:0032561 guanyl ribonucleotide binding 43/1692 400/18639 0.1075 1.18421542553191 0.138796846809185 0.560241872782259 GO:0140104 molecular carrier activity 28/1692 249/18639 0.112449799196787 1.23874220285397 0.139226065406315 0.560241872782259 GO:0016853 isomerase activity 21/1692 180/18639 0.116666666666667 1.28519503546099 0.139875851187829 0.560935580702043 GO:0070279 vitamin B6 binding 8/1692 57/18639 0.140350877192982 1.54609929078014 0.141967838241272 0.567388469161546 GO:0003924 GTPase activity 36/1692 331/18639 0.108761329305136 1.19811017548371 0.146618897586262 0.582165413603464 GO:0004559 alpha-mannosidase activity 3/1692 15/18639 0.2 2.2031914893617 0.149614873062054 0.582165413603464 GO:0015929 hexosaminidase activity 3/1692 15/18639 0.2 2.2031914893617 0.149614873062054 0.582165413603464 GO:0016846 carbon-sulfur lyase activity 3/1692 15/18639 0.2 2.2031914893617 0.149614873062054 0.582165413603464 GO:0050780 dopamine receptor binding 3/1692 15/18639 0.2 2.2031914893617 0.149614873062054 0.582165413603464 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/1692 15/18639 0.2 2.2031914893617 0.149614873062054 0.582165413603464 GO:0004602 glutathione peroxidase activity 4/1692 23/18639 0.173913043478261 1.91581868640148 0.150444780568576 0.582165413603464 GO:0017134 fibroblast growth factor binding 4/1692 23/18639 0.173913043478261 1.91581868640148 0.150444780568576 0.582165413603464 GO:0140103 catalytic activity, acting on a glycoprotein 4/1692 23/18639 0.173913043478261 1.91581868640148 0.150444780568576 0.582165413603464 GO:0030331 nuclear estrogen receptor binding 6/1692 40/18639 0.15 1.65239361702128 0.150619817647194 0.582165413603464 GO:0004867 serine-type endopeptidase inhibitor activity 12/1692 95/18639 0.126315789473684 1.39148936170213 0.151361350222512 0.583113398398201 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 11/1692 86/18639 0.127906976744186 1.40901781296388 0.154877317447063 0.594708653595747 GO:0008378 galactosyltransferase activity 5/1692 32/18639 0.15625 1.72124335106383 0.160070058980501 0.610656880850938 GO:0030515 snoRNA binding 5/1692 32/18639 0.15625 1.72124335106383 0.160070058980501 0.610656880850938 GO:0008237 metallopeptidase activity 21/1692 184/18639 0.114130434782609 1.25725601295097 0.163006214515894 0.61881744295052 GO:0001530 lipopolysaccharide binding 6/1692 41/18639 0.146341463414634 1.61209133367929 0.163789127453287 0.61881744295052 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/1692 41/18639 0.146341463414634 1.61209133367929 0.163789127453287 0.61881744295052 GO:0005006 epidermal growth factor receptor activity 7/1692 50/18639 0.14 1.54223404255319 0.164402858020188 0.619145378761926 GO:0008194 UDP-glycosyltransferase activity 17/1692 145/18639 0.117241379310345 1.29152604548789 0.165325868858649 0.62063225530004 GO:0019199 transmembrane receptor protein kinase activity 10/1692 78/18639 0.128205128205128 1.41230223677032 0.167637357816412 0.626073310885751 GO:0140097 catalytic activity, acting on DNA 36/1692 336/18639 0.107142857142857 1.1802811550152 0.168338390437108 0.626073310885751 GO:0070840 dynein complex binding 4/1692 24/18639 0.166666666666667 1.83599290780142 0.16837375850204 0.626073310885751 GO:0005024 transforming growth factor beta receptor activity 3/1692 16/18639 0.1875 2.0654920212766 0.172411073321087 0.631099723215819 GO:0015385 sodium:proton antiporter activity 3/1692 16/18639 0.1875 2.0654920212766 0.172411073321087 0.631099723215819 GO:0015923 mannosidase activity 3/1692 16/18639 0.1875 2.0654920212766 0.172411073321087 0.631099723215819 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1692 16/18639 0.1875 2.0654920212766 0.172411073321087 0.631099723215819 GO:0055102 lipase inhibitor activity 3/1692 16/18639 0.1875 2.0654920212766 0.172411073321087 0.631099723215819 GO:0008017 microtubule binding 30/1692 276/18639 0.108695652173913 1.19738667900093 0.172949794572132 0.631105616839303 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/1692 33/18639 0.151515151515152 1.66908446163765 0.175505647990131 0.638449338663788 GO:0016859 cis-trans isomerase activity 6/1692 42/18639 0.142857142857143 1.57370820668693 0.177427831234258 0.639502152454763 GO:0035198 miRNA binding 6/1692 42/18639 0.142857142857143 1.57370820668693 0.177427831234258 0.639502152454763 GO:0043175 RNA polymerase core enzyme binding 6/1692 42/18639 0.142857142857143 1.57370820668693 0.177427831234258 0.639502152454763 GO:0005496 steroid binding 13/1692 108/18639 0.12037037037037 1.32599487785658 0.179910744697951 0.6464682722327 GO:0016874 ligase activity 19/1692 167/18639 0.11377245508982 1.25331252388839 0.180990833699 0.646897839064731 GO:0005516 calmodulin binding 23/1692 207/18639 0.111111111111111 1.22399527186761 0.181580803516914 0.646897839064731 GO:0016758 hexosyltransferase activity 22/1692 197/18639 0.111675126903553 1.23020844583648 0.18168194629052 0.646897839064731 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/1692 128/18639 0.1171875 1.29093251329787 0.184207470589698 0.651454518187923 GO:0015026 coreceptor activity 8/1692 61/18639 0.131147540983607 1.44471573072899 0.185894340152306 0.651454518187923 GO:0019905 syntaxin binding 8/1692 61/18639 0.131147540983607 1.44471573072899 0.185894340152306 0.651454518187923 GO:0004709 MAP kinase kinase kinase activity 4/1692 25/18639 0.16 1.76255319148936 0.187005971201768 0.651454518187923 GO:0008139 nuclear localization sequence binding 4/1692 25/18639 0.16 1.76255319148936 0.187005971201768 0.651454518187923 GO:0042974 nuclear retinoic acid receptor binding 4/1692 25/18639 0.16 1.76255319148936 0.187005971201768 0.651454518187923 GO:0000049 tRNA binding 10/1692 80/18639 0.125 1.37699468085106 0.187397129487249 0.651454518187923 GO:0048306 calcium-dependent protein binding 10/1692 80/18639 0.125 1.37699468085106 0.187397129487249 0.651454518187923 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/1692 34/18639 0.147058823529412 1.61999374217772 0.191477703917546 0.660248642355509 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/1692 43/18639 0.13953488372093 1.53711034141514 0.191506029003558 0.660248642355509 GO:0019210 kinase inhibitor activity 11/1692 90/18639 0.122222222222222 1.34639479905437 0.191612584717641 0.660248642355509 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:0016805 dipeptidase activity 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:0051787 misfolded protein binding 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:0070402 NADPH binding 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:0070492 oligosaccharide binding 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:1990226 histone methyltransferase binding 3/1692 17/18639 0.176470588235294 1.94399249061327 0.19610103305975 0.664030875634599 GO:0001618 virus receptor activity 10/1692 81/18639 0.123456790123457 1.35999474651957 0.197651847074744 0.667358966416161 GO:0004864 protein phosphatase inhibitor activity 7/1692 53/18639 0.132075471698113 1.45493777599358 0.202291603062815 0.670901813637862 GO:0015631 tubulin binding 40/1692 385/18639 0.103896103896104 1.14451505940868 0.205006786081751 0.670901813637862 GO:0001223 transcription coactivator binding 6/1692 44/18639 0.136363636363636 1.50217601547389 0.205992279504503 0.670901813637862 GO:0030247 polysaccharide binding 4/1692 26/18639 0.153846153846154 1.69476268412439 0.20625888153292 0.670901813637862 GO:0097602 cullin family protein binding 4/1692 26/18639 0.153846153846154 1.69476268412439 0.20625888153292 0.670901813637862 GO:0004540 RNA nuclease activity 14/1692 121/18639 0.115702479338843 1.27457358888694 0.207505438915083 0.670901813637862 GO:0000175 3'-5'-RNA exonuclease activity 5/1692 35/18639 0.142857142857143 1.57370820668693 0.207938007122994 0.670901813637862 GO:0034061 DNA polymerase activity 5/1692 35/18639 0.142857142857143 1.57370820668693 0.207938007122994 0.670901813637862 GO:0061631 ubiquitin conjugating enzyme activity 5/1692 35/18639 0.142857142857143 1.57370820668693 0.207938007122994 0.670901813637862 GO:0140272 exogenous protein binding 10/1692 82/18639 0.121951219512195 1.34340944473275 0.208142791182804 0.670901813637862 GO:0003925 G protein activity 7/1692 54/18639 0.12962962962963 1.42799448384555 0.215612046974663 0.670901813637862 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 14/1692 122/18639 0.114754098360656 1.26412626438786 0.21622355738343 0.670901813637862 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1692 18/18639 0.166666666666667 1.83599290780142 0.220514506372072 0.670901813637862 GO:0008525 phosphatidylcholine transporter activity 3/1692 18/18639 0.166666666666667 1.83599290780142 0.220514506372072 0.670901813637862 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1692 18/18639 0.166666666666667 1.83599290780142 0.220514506372072 0.670901813637862 GO:0050811 GABA receptor binding 3/1692 18/18639 0.166666666666667 1.83599290780142 0.220514506372072 0.670901813637862 GO:0008009 chemokine activity 6/1692 45/18639 0.133333333333333 1.46879432624113 0.220853887501828 0.670901813637862 GO:0051219 phosphoprotein binding 11/1692 93/18639 0.118279569892473 1.3029627087623 0.221495279769364 0.670901813637862 GO:0000993 RNA polymerase II complex binding 5/1692 36/18639 0.138888888888889 1.52999408983452 0.224837014666342 0.670901813637862 GO:0055106 ubiquitin-protein transferase regulator activity 5/1692 36/18639 0.138888888888889 1.52999408983452 0.224837014666342 0.670901813637862 GO:0001671 ATPase activator activity 4/1692 27/18639 0.148148148148148 1.63199369582348 0.226049264578019 0.670901813637862 GO:0004364 glutathione transferase activity 4/1692 27/18639 0.148148148148148 1.63199369582348 0.226049264578019 0.670901813637862 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1692 27/18639 0.148148148148148 1.63199369582348 0.226049264578019 0.670901813637862 GO:0000182 rDNA binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0004955 prostaglandin receptor activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0005381 iron ion transmembrane transporter activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0008140 cAMP response element binding protein binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0008239 dipeptidyl-peptidase activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0015187 glycine transmembrane transporter activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0016427 tRNA (cytidine) methyltransferase activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0030957 Tat protein binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0031434 mitogen-activated protein kinase kinase binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0035374 chondroitin sulfate binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0043208 glycosphingolipid binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0043295 glutathione binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0050815 phosphoserine residue binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0070739 protein-glutamic acid ligase activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0070740 tubulin-glutamic acid ligase activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0099122 RNA polymerase II C-terminal domain binding 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0141109 transporter activator activity 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/1692 10/18639 0.2 2.2031914893617 0.228392106770336 0.670901813637862 GO:0019003 GDP binding 9/1692 75/18639 0.12 1.32191489361702 0.238513603037652 0.697044558947936 GO:0004721 phosphoprotein phosphatase activity 19/1692 175/18639 0.108571428571429 1.19601823708207 0.238938130993195 0.697044558947936 GO:0004386 helicase activity 17/1692 155/18639 0.109677419354839 1.20820178448868 0.241205213298881 0.697044558947936 GO:0019212 phosphatase inhibitor activity 7/1692 56/18639 0.125 1.37699468085106 0.243147504914231 0.697044558947936 GO:0030170 pyridoxal phosphate binding 7/1692 56/18639 0.125 1.37699468085106 0.243147504914231 0.697044558947936 GO:0101005 deubiquitinase activity 13/1692 115/18639 0.11304347826087 1.24528214616096 0.243432794208999 0.697044558947936 GO:0031420 alkali metal ion binding 3/1692 19/18639 0.157894736842105 1.73936170212766 0.245488463001135 0.697044558947936 GO:0070003 threonine-type peptidase activity 3/1692 19/18639 0.157894736842105 1.73936170212766 0.245488463001135 0.697044558947936 GO:0097001 ceramide binding 3/1692 19/18639 0.157894736842105 1.73936170212766 0.245488463001135 0.697044558947936 GO:0045499 chemorepellent activity 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0046625 sphingolipid binding 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0046966 nuclear thyroid hormone receptor binding 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0051019 mitogen-activated protein kinase binding 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0051959 dynein light intermediate chain binding 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0097718 disordered domain specific binding 4/1692 28/18639 0.142857142857143 1.57370820668693 0.246294213964821 0.697044558947936 GO:0008235 metalloexopeptidase activity 8/1692 66/18639 0.121212121212121 1.33526756931012 0.247687421580711 0.697044558947936 GO:0140034 methylation-dependent protein binding 9/1692 76/18639 0.118421052631579 1.30452127659574 0.250545994440882 0.697044558947936 GO:0140938 histone H3 methyltransferase activity 6/1692 47/18639 0.127659574468085 1.40629244001811 0.251567790039049 0.697044558947936 GO:0000149 SNARE binding 12/1692 106/18639 0.113207547169811 1.24708952228021 0.253358900680176 0.697044558947936 GO:0030246 carbohydrate binding 29/1692 280/18639 0.103571428571429 1.14093844984802 0.253916009221491 0.697044558947936 GO:0004601 peroxidase activity 7/1692 57/18639 0.12280701754386 1.35283687943262 0.257312658248445 0.697044558947936 GO:0000146 microfilament motor activity 5/1692 38/18639 0.131578947368421 1.44946808510638 0.259749341183573 0.697044558947936 GO:0005109 frizzled binding 5/1692 38/18639 0.131578947368421 1.44946808510638 0.259749341183573 0.697044558947936 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/1692 38/18639 0.131578947368421 1.44946808510638 0.259749341183573 0.697044558947936 GO:0003724 RNA helicase activity 9/1692 77/18639 0.116883116883117 1.28757944183476 0.262774711816192 0.697044558947936 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0002162 dystroglycan binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0003953 NAD+ nucleosidase activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0004954 prostanoid receptor activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0008172 S-methyltransferase activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0008432 JUN kinase binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0019864 IgG binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0032794 GTPase activating protein binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0034713 type I transforming growth factor beta receptor binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0048407 platelet-derived growth factor binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0050786 RAGE receptor binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0050998 nitric-oxide synthase binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:1900750 oligopeptide binding 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:1990948 ubiquitin ligase inhibitor activity 2/1692 11/18639 0.181818181818182 2.00290135396518 0.263393858870539 0.697044558947936 GO:0000339 RNA cap binding 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0016408 C-acyltransferase activity 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0031418 L-ascorbic acid binding 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0052745 inositol phosphate phosphatase activity 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0061608 nuclear import signal receptor activity 3/1692 20/18639 0.15 1.65239361702128 0.270868658660598 0.707268164280451 GO:0061980 regulatory RNA binding 7/1692 58/18639 0.120689655172414 1.3295121056493 0.271708700344453 0.707888520853064 GO:0030145 manganese ion binding 8/1692 68/18639 0.117647058823529 1.29599499374218 0.274089156194797 0.710587261235521 GO:0004843 cysteine-type deubiquitinase activity 12/1692 108/18639 0.111111111111111 1.22399527186761 0.274164185768324 0.710587261235521 GO:0042626 ATPase-coupled transmembrane transporter activity 11/1692 98/18639 0.112244897959184 1.23648501953973 0.275006446923615 0.710587261235521 GO:0004197 cysteine-type endopeptidase activity 10/1692 88/18639 0.113636363636364 1.25181334622824 0.275403411094953 0.710587261235521 GO:0016791 phosphatase activity 28/1692 273/18639 0.102564102564103 1.12984178941626 0.275768332870977 0.710587261235521 GO:0030295 protein kinase activator activity 15/1692 139/18639 0.107913669064748 1.18877238634624 0.279260175176124 0.712979506568112 GO:0005004 GPI-linked ephrin receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0005008 hepatocyte growth factor receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0005009 insulin receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0005011 macrophage colony-stimulating factor receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0005020 stem cell factor receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0008288 boss receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0036332 placental growth factor receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0038062 protein tyrosine kinase collagen receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0060175 brain-derived neurotrophic factor receptor activity 6/1692 49/18639 0.122448979591837 1.3488927485888 0.283371429418986 0.712979506568112 GO:0001786 phosphatidylserine binding 7/1692 59/18639 0.11864406779661 1.30697800216372 0.286309699484124 0.714043487429609 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1692 59/18639 0.11864406779661 1.30697800216372 0.286309699484124 0.714043487429609 GO:0002039 p53 binding 8/1692 69/18639 0.115942028985507 1.27721245760099 0.287572810321914 0.714043487429609 GO:0008186 ATP-dependent activity, acting on RNA 9/1692 79/18639 0.113924050632911 1.25498249394021 0.287757561477358 0.714043487429609 GO:0016769 transferase activity, transferring nitrogenous groups 4/1692 30/18639 0.133333333333333 1.46879432624113 0.287822896919178 0.714043487429609 GO:0070566 adenylyltransferase activity 4/1692 30/18639 0.133333333333333 1.46879432624113 0.287822896919178 0.714043487429609 GO:0004713 protein tyrosine kinase activity 15/1692 140/18639 0.107142857142857 1.1802811550152 0.288644405135931 0.714043487429609 GO:0005126 cytokine receptor binding 28/1692 275/18639 0.101818181818182 1.1216247582205 0.289054532925081 0.714043487429609 GO:0004532 RNA exonuclease activity 5/1692 40/18639 0.125 1.37699468085106 0.295810092148388 0.714043487429609 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1692 21/18639 0.142857142857143 1.57370820668693 0.29651072754571 0.714043487429609 GO:0010314 phosphatidylinositol-5-phosphate binding 3/1692 21/18639 0.142857142857143 1.57370820668693 0.29651072754571 0.714043487429609 GO:0019200 carbohydrate kinase activity 3/1692 21/18639 0.142857142857143 1.57370820668693 0.29651072754571 0.714043487429609 GO:0036122 BMP binding 3/1692 21/18639 0.142857142857143 1.57370820668693 0.29651072754571 0.714043487429609 GO:0070182 DNA polymerase binding 3/1692 21/18639 0.142857142857143 1.57370820668693 0.29651072754571 0.714043487429609 GO:0004859 phospholipase inhibitor activity 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0005078 MAP-kinase scaffold activity 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0005165 neurotrophin receptor binding 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0016208 AMP binding 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0016423 tRNA (guanine) methyltransferase activity 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0070008 serine-type exopeptidase activity 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0097371 MDM2/MDM4 family protein binding 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/1692 12/18639 0.166666666666667 1.83599290780142 0.298402751117724 0.714043487429609 GO:0005007 fibroblast growth factor receptor activity 6/1692 50/18639 0.12 1.32191489361702 0.299594416427913 0.714043487429609 GO:0005017 platelet-derived growth factor receptor activity 6/1692 50/18639 0.12 1.32191489361702 0.299594416427913 0.714043487429609 GO:0005019 platelet-derived growth factor beta-receptor activity 6/1692 50/18639 0.12 1.32191489361702 0.299594416427913 0.714043487429609 GO:0048020 CCR chemokine receptor binding 6/1692 50/18639 0.12 1.32191489361702 0.299594416427913 0.714043487429609 GO:0004714 transmembrane receptor protein tyrosine kinase activity 7/1692 60/18639 0.116666666666667 1.28519503546099 0.301089589554011 0.714707611567602 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/1692 60/18639 0.116666666666667 1.28519503546099 0.301089589554011 0.714707611567602 GO:0072349 modified amino acid transmembrane transporter activity 4/1692 31/18639 0.129032258064516 1.42141386410432 0.308949652650172 0.731886777951517 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 14/1692 132/18639 0.106060606060606 1.16835912314636 0.310892429502994 0.735007252849131 GO:0042287 MHC protein binding 5/1692 41/18639 0.121951219512195 1.34340944473275 0.31414633724493 0.741082731631043 GO:0005010 insulin-like growth factor receptor activity 6/1692 51/18639 0.117647058823529 1.29599499374218 0.315985062593321 0.741082731631043 GO:0005021 vascular endothelial growth factor receptor activity 6/1692 51/18639 0.117647058823529 1.29599499374218 0.315985062593321 0.741082731631043 GO:0005030 neurotrophin receptor activity 6/1692 51/18639 0.117647058823529 1.29599499374218 0.315985062593321 0.741082731631043 GO:0004407 histone deacetylase activity 3/1692 22/18639 0.136363636363636 1.50217601547389 0.322280882820677 0.748426045962458 GO:0033558 protein lysine deacetylase activity 3/1692 22/18639 0.136363636363636 1.50217601547389 0.322280882820677 0.748426045962458 GO:0070034 telomerase RNA binding 3/1692 22/18639 0.136363636363636 1.50217601547389 0.322280882820677 0.748426045962458 GO:0140784 metal ion sensor activity 3/1692 22/18639 0.136363636363636 1.50217601547389 0.322280882820677 0.748426045962458 GO:0042379 chemokine receptor binding 8/1692 72/18639 0.111111111111111 1.22399527186761 0.328911541658564 0.748426045962458 GO:0022884 macromolecule transmembrane transporter activity 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0042910 xenobiotic transmembrane transporter activity 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0043425 bHLH transcription factor binding 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0070717 poly-purine tract binding 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0071813 lipoprotein particle binding 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0071814 protein-lipid complex binding 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0140142 nucleocytoplasmic carrier activity 4/1692 32/18639 0.125 1.37699468085106 0.330218166031554 0.748426045962458 GO:0015179 L-amino acid transmembrane transporter activity 7/1692 62/18639 0.112903225806452 1.24373713109128 0.331081920312347 0.748426045962458 GO:0004722 protein serine/threonine phosphatase activity 11/1692 103/18639 0.106796116504854 1.17646147490188 0.332000303187026 0.748426045962458 GO:0004520 DNA endonuclease activity 5/1692 42/18639 0.119047619047619 1.31142350557244 0.332621811030155 0.748426045962458 GO:0042056 chemoattractant activity 5/1692 42/18639 0.119047619047619 1.31142350557244 0.332621811030155 0.748426045962458 GO:0005542 folic acid binding 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0019855 calcium channel inhibitor activity 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0035325 Toll-like receptor binding 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0035673 oligopeptide transmembrane transporter activity 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0070123 transforming growth factor beta receptor activity, type III 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1692 13/18639 0.153846153846154 1.69476268412439 0.333129210245418 0.748426045962458 GO:0004521 RNA endonuclease activity 8/1692 73/18639 0.10958904109589 1.20722821334888 0.342919199959657 0.765355784067517 GO:0004518 nuclease activity 21/1692 209/18639 0.100478468899522 1.1068665377176 0.345480834125861 0.765355784067517 GO:0051015 actin filament binding 21/1692 209/18639 0.100478468899522 1.1068665377176 0.345480834125861 0.765355784067517 GO:0005212 structural constituent of eye lens 3/1692 23/18639 0.130434782608696 1.43686401480111 0.348056298158493 0.765355784067517 GO:0070577 lysine-acetylated histone binding 3/1692 23/18639 0.130434782608696 1.43686401480111 0.348056298158493 0.765355784067517 GO:0140102 catalytic activity, acting on a rRNA 3/1692 23/18639 0.130434782608696 1.43686401480111 0.348056298158493 0.765355784067517 GO:0042562 hormone binding 10/1692 94/18639 0.106382978723404 1.17191036668176 0.348069958633211 0.765355784067517 GO:0005003 ephrin receptor activity 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0005005 transmembrane-ephrin receptor activity 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0016860 intramolecular oxidoreductase activity 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0017046 peptide hormone binding 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0038064 collagen receptor activity 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0140296 general transcription initiation factor binding 6/1692 53/18639 0.113207547169811 1.24708952228021 0.349132510859736 0.765355784067517 GO:0008200 ion channel inhibitor activity 5/1692 43/18639 0.116279069767442 1.28092528451262 0.351189677086286 0.768431788782843 GO:0004527 exonuclease activity 9/1692 84/18639 0.107142857142857 1.1802811550152 0.352518230996665 0.769905058403498 GO:0031491 nucleosome binding 8/1692 74/18639 0.108108108108108 1.19091431857389 0.357007221712562 0.776821269467148 GO:0035064 methylated histone binding 8/1692 74/18639 0.108108108108108 1.19091431857389 0.357007221712562 0.776821269467148 GO:0017069 snRNA binding 6/1692 54/18639 0.111111111111111 1.22399527186761 0.36582256884537 0.778594234156517 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/1692 54/18639 0.111111111111111 1.22399527186761 0.36582256884537 0.778594234156517 GO:0019209 kinase activator activity 15/1692 148/18639 0.101351351351351 1.11648217366302 0.366663624682446 0.778594234156517 GO:0005161 platelet-derived growth factor receptor binding 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0008174 mRNA methyltransferase activity 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0008195 phosphatidate phosphatase activity 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0008559 ABC-type xenobiotic transporter activity 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0015926 glucosidase activity 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0032036 myosin heavy chain binding 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0034236 protein kinase A catalytic subunit binding 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0070742 C2H2 zinc finger domain binding 2/1692 14/18639 0.142857142857143 1.57370820668693 0.367336121074482 0.778594234156517 GO:0019783 ubiquitin-like protein peptidase activity 13/1692 127/18639 0.102362204724409 1.1276176914056 0.367386834404544 0.778594234156517 GO:0001664 G protein-coupled receptor binding 29/1692 297/18639 0.0976430976430976 1.07563220861093 0.367876291424094 0.778594234156517 GO:0001046 core promoter sequence-specific DNA binding 5/1692 44/18639 0.113636363636364 1.25181334622824 0.36980472805831 0.778594234156517 GO:0016248 channel inhibitor activity 5/1692 44/18639 0.113636363636364 1.25181334622824 0.36980472805831 0.778594234156517 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/1692 44/18639 0.113636363636364 1.25181334622824 0.36980472805831 0.778594234156517 GO:0030547 signaling receptor inhibitor activity 5/1692 44/18639 0.113636363636364 1.25181334622824 0.36980472805831 0.778594234156517 GO:0008175 tRNA methyltransferase activity 4/1692 34/18639 0.117647058823529 1.29599499374218 0.372901839662426 0.778594234156517 GO:1990782 protein tyrosine kinase binding 12/1692 117/18639 0.102564102564103 1.12984178941626 0.373116431461634 0.778594234156517 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/1692 24/18639 0.125 1.37699468085106 0.373725232395128 0.778594234156517 GO:0030215 semaphorin receptor binding 3/1692 24/18639 0.125 1.37699468085106 0.373725232395128 0.778594234156517 GO:0035035 histone acetyltransferase binding 3/1692 24/18639 0.125 1.37699468085106 0.373725232395128 0.778594234156517 GO:0048027 mRNA 5'-UTR binding 3/1692 24/18639 0.125 1.37699468085106 0.373725232395128 0.778594234156517 GO:0140033 acetylation-dependent protein binding 3/1692 24/18639 0.125 1.37699468085106 0.373725232395128 0.778594234156517 GO:0042578 phosphoric ester hydrolase activity 35/1692 363/18639 0.0964187327823691 1.06214465740578 0.379164983758883 0.788528948525111 GO:0098632 cell-cell adhesion mediator activity 6/1692 55/18639 0.109090909090909 1.20174081237911 0.382547100538757 0.794156966666147 GO:0017022 myosin binding 8/1692 76/18639 0.105263157894737 1.15957446808511 0.385345092206847 0.797148738280009 GO:0098631 cell adhesion mediator activity 8/1692 76/18639 0.105263157894737 1.15957446808511 0.385345092206847 0.797148738280009 GO:0141110 transporter inhibitor activity 5/1692 45/18639 0.111111111111111 1.22399527186761 0.38842358312787 0.798266516589558 GO:0140566 histone reader activity 4/1692 35/18639 0.114285714285714 1.25896656534954 0.394187495473965 0.798266516589558 GO:0008483 transaminase activity 3/1692 25/18639 0.12 1.32191489361702 0.399186949830586 0.798266516589558 GO:0015271 outward rectifier potassium channel activity 3/1692 25/18639 0.12 1.32191489361702 0.399186949830586 0.798266516589558 GO:0015645 fatty acid ligase activity 3/1692 25/18639 0.12 1.32191489361702 0.399186949830586 0.798266516589558 GO:0017056 structural constituent of nuclear pore 3/1692 25/18639 0.12 1.32191489361702 0.399186949830586 0.798266516589558 GO:0120515 fatty acid-CoA ligase activity 3/1692 25/18639 0.12 1.32191489361702 0.399186949830586 0.798266516589558 GO:0008083 growth factor activity 16/1692 162/18639 0.0987654320987654 1.08799579721566 0.40009421613804 0.798266516589558 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0004953 icosanoid receptor activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0005523 tropomyosin binding 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0008242 omega peptidase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0017081 chloride channel regulator activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0042809 nuclear vitamin D receptor binding 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0045504 dynein heavy chain binding 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0061578 K63-linked deubiquitinase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0140161 monocarboxylate:sodium symporter activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0141050 histone H3K deacetylase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0141051 histone H4K deacetylase activity 2/1692 15/18639 0.133333333333333 1.46879432624113 0.400831697691778 0.798266516589558 GO:0008173 RNA methyltransferase activity 7/1692 67/18639 0.104477611940299 1.1509209272785 0.407399519159332 0.80860546454766 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1692 67/18639 0.104477611940299 1.1509209272785 0.407399519159332 0.80860546454766 GO:0005484 SNAP receptor activity 4/1692 36/18639 0.111111111111111 1.22399527186761 0.415356305574918 0.821622321633887 GO:0045505 dynein intermediate chain binding 4/1692 36/18639 0.111111111111111 1.22399527186761 0.415356305574918 0.821622321633887 GO:0003727 single-stranded RNA binding 9/1692 89/18639 0.101123595505618 1.11397322495816 0.418934795688884 0.827308209973846 GO:0008143 poly(A) binding 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0019865 immunoglobulin binding 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0030507 spectrin binding 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0043548 phosphatidylinositol 3-kinase binding 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0051139 metal cation:proton antiporter activity 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0052742 phosphatidylinositol kinase activity 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0120014 phospholipid transfer activity 3/1692 26/18639 0.115384615384615 1.27107201309329 0.424351480478108 0.828260780002952 GO:0016835 carbon-oxygen lyase activity 8/1692 79/18639 0.10126582278481 1.11553999461352 0.42796871667146 0.829510225023369 GO:0000287 magnesium ion binding 22/1692 230/18639 0.0956521739130435 1.05370027752081 0.431107318698472 0.829510225023369 GO:0008408 3'-5' exonuclease activity 6/1692 58/18639 0.103448275862069 1.13958180484226 0.432622795845184 0.829510225023369 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0004708 MAP kinase kinase activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0015562 efflux transmembrane transporter activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0017070 U6 snRNA binding 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0022841 potassium ion leak channel activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0022858 alanine transmembrane transporter activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0070411 I-SMAD binding 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0097027 ubiquitin-protein transferase activator activity 2/1692 16/18639 0.125 1.37699468085106 0.43346321545902 0.829510225023369 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1692 48/18639 0.104166666666667 1.14749556737589 0.443899772859484 0.840444036159714 GO:0008094 ATP-dependent activity, acting on DNA 20/1692 210/18639 0.0952380952380952 1.04913880445795 0.445352894915732 0.840444036159714 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 9/1692 91/18639 0.0989010989010989 1.08949029693711 0.44552291449084 0.840444036159714 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0005044 scavenger receptor activity 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0008266 poly(U) RNA binding 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0008320 protein transmembrane transporter activity 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0016405 CoA-ligase activity 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/1692 27/18639 0.111111111111111 1.22399527186761 0.449139257465619 0.840444036159714 GO:0015459 potassium channel regulator activity 6/1692 59/18639 0.101694915254237 1.12026685899748 0.449186542603041 0.840444036159714 GO:0045309 protein phosphorylated amino acid binding 6/1692 59/18639 0.101694915254237 1.12026685899748 0.449186542603041 0.840444036159714 GO:0005319 lipid transporter activity 17/1692 178/18639 0.0955056179775281 1.0520858235716 0.450471524708385 0.840444036159714 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0140791 histone H2AXS140 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1692 81/18639 0.0987654320987654 1.08799579721566 0.456249436064534 0.840444036159714 GO:0005501 retinoid binding 4/1692 38/18639 0.105263157894737 1.15957446808511 0.457131149060896 0.840444036159714 GO:0019840 isoprenoid binding 4/1692 38/18639 0.105263157894737 1.15957446808511 0.457131149060896 0.840444036159714 GO:0043531 ADP binding 4/1692 38/18639 0.105263157894737 1.15957446808511 0.457131149060896 0.840444036159714 GO:0001222 transcription corepressor binding 5/1692 49/18639 0.102040816326531 1.12407729049066 0.462141630068631 0.840444036159714 GO:0060590 ATPase regulator activity 5/1692 49/18639 0.102040816326531 1.12407729049066 0.462141630068631 0.840444036159714 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0008569 minus-end-directed microtubule motor activity 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0015278 intracellularly gated calcium channel activity 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0016018 cyclosporin A binding 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0019198 transmembrane receptor protein phosphatase activity 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0038191 neuropilin binding 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0070403 NAD+ binding 2/1692 17/18639 0.117647058823529 1.29599499374218 0.465111506445589 0.840444036159714 GO:0044325 transmembrane transporter binding 13/1692 136/18639 0.0955882352941176 1.05299593241552 0.465454714769472 0.840444036159714 GO:0140789 histone phosphatase activity 13/1692 136/18639 0.0955882352941176 1.05299593241552 0.465454714769472 0.840444036159714 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1692 60/18639 0.1 1.10159574468085 0.465641759608488 0.840444036159714 GO:0140658 ATP-dependent chromatin remodeler activity 15/1692 158/18639 0.0949367088607595 1.04581874495018 0.467653001482583 0.842779565555269 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1692 82/18639 0.0975609756097561 1.0747275557862 0.470297876453348 0.844954135829793 GO:0033549 MAP kinase phosphatase activity 8/1692 82/18639 0.0975609756097561 1.0747275557862 0.470297876453348 0.844954135829793 GO:0046875 ephrin receptor binding 3/1692 28/18639 0.107142857142857 1.1802811550152 0.473480662685716 0.848078930877616 GO:0051537 2 iron, 2 sulfur cluster binding 3/1692 28/18639 0.107142857142857 1.1802811550152 0.473480662685716 0.848078930877616 GO:0000217 DNA secondary structure binding 4/1692 39/18639 0.102564102564103 1.12984178941626 0.477641988058058 0.854230343939449 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1692 61/18639 0.0983606557377049 1.08353679804674 0.4819638817037 0.859343795146962 GO:0016836 hydro-lyase activity 6/1692 61/18639 0.0983606557377049 1.08353679804674 0.4819638817037 0.859343795146962 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1692 83/18639 0.0963855421686747 1.06177903101769 0.48426365787908 0.862136057587756 GO:0004519 endonuclease activity 12/1692 127/18639 0.094488188976378 1.04087786898978 0.486727800652633 0.863905084239944 GO:0042826 histone deacetylase binding 12/1692 127/18639 0.094488188976378 1.04087786898978 0.486727800652633 0.863905084239944 GO:0003689 DNA clamp loader activity 15/1692 160/18639 0.09375 1.0327460106383 0.487774523418849 0.86445711163974 GO:0004706 JUN kinase kinase kinase activity 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0016854 racemase and epimerase activity 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0017075 syntaxin-1 binding 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0070064 proline-rich region binding 2/1692 18/18639 0.111111111111111 1.22399527186761 0.495686131454779 0.865835247222371 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1692 40/18639 0.1 1.10159574468085 0.497845532048021 0.865835247222371 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1692 40/18639 0.1 1.10159574468085 0.497845532048021 0.865835247222371 GO:0070851 growth factor receptor binding 13/1692 139/18639 0.0935251798561151 1.03026940150008 0.497897814183059 0.865835247222371 GO:0030544 Hsp70 protein binding 5/1692 51/18639 0.0980392156862745 1.07999582811848 0.498052145605022 0.865835247222371 GO:0008013 beta-catenin binding 10/1692 106/18639 0.0943396226415094 1.03924126856684 0.498055523564179 0.865835247222371 GO:0017018 myosin phosphatase activity 8/1692 84/18639 0.0952380952380952 1.04913880445795 0.498131597550913 0.865835247222371 GO:0106310 protein serine kinase activity 33/1692 361/18639 0.0914127423822715 1.00699888017917 0.510264622321038 0.88561437404316 GO:0005507 copper ion binding 6/1692 63/18639 0.0952380952380952 1.04913880445795 0.514117917297388 0.889073995310669 GO:1901682 sulfur compound transmembrane transporter activity 6/1692 63/18639 0.0952380952380952 1.04913880445795 0.514117917297388 0.889073995310669 GO:0001727 lipid kinase activity 4/1692 41/18639 0.0975609756097561 1.0747275557862 0.517704904459166 0.889073995310669 GO:0042169 SH2 domain binding 4/1692 41/18639 0.0975609756097561 1.0747275557862 0.517704904459166 0.889073995310669 GO:0140318 protein transporter activity 4/1692 41/18639 0.0975609756097561 1.0747275557862 0.517704904459166 0.889073995310669 GO:0140828 metal cation:monoatomic cation antiporter activity 4/1692 41/18639 0.0975609756097561 1.0747275557862 0.517704904459166 0.889073995310669 GO:0008187 poly-pyrimidine tract binding 3/1692 30/18639 0.1 1.10159574468085 0.520592463170254 0.889073995310669 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/1692 30/18639 0.1 1.10159574468085 0.520592463170254 0.889073995310669 GO:0048019 receptor antagonist activity 3/1692 30/18639 0.1 1.10159574468085 0.520592463170254 0.889073995310669 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0008574 plus-end-directed microtubule motor activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0016918 retinal binding 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0022840 leak channel activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0022842 narrow pore channel activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0043395 heparan sulfate proteoglycan binding 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:1990380 K48-linked deubiquitinase activity 2/1692 19/18639 0.105263157894737 1.15957446808511 0.525121151272855 0.889073995310669 GO:0061775 cohesin loader activity 14/1692 153/18639 0.0915032679738562 1.00799610624392 0.528647261316258 0.893756161218135 GO:0051018 protein kinase A binding 5/1692 53/18639 0.0943396226415094 1.03924126856684 0.533010055448351 0.899837378091685 GO:0031492 nucleosomal DNA binding 4/1692 42/18639 0.0952380952380952 1.04913880445795 0.53718733534643 0.905588406071816 GO:0005164 tumor necrosis factor receptor binding 3/1692 31/18639 0.0967741935483871 1.06606039807824 0.54326847858312 0.911914946193094 GO:0016411 acylglycerol O-acyltransferase activity 3/1692 31/18639 0.0967741935483871 1.06606039807824 0.54326847858312 0.911914946193094 GO:0016878 acid-thiol ligase activity 3/1692 31/18639 0.0967741935483871 1.06606039807824 0.54326847858312 0.911914946193094 GO:0051082 unfolded protein binding 11/1692 121/18639 0.0909090909090909 1.00145067698259 0.544207547911539 0.912188115258286 GO:0004674 protein serine/threonine kinase activity 39/1692 433/18639 0.0900692840646651 0.992199400520859 0.545678136781344 0.913350157718062 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1692 54/18639 0.0925925925925926 1.01999605988968 0.5500700030609 0.919391541389129 GO:0016505 peptidase activator activity involved in apoptotic process 2/1692 20/18639 0.1 1.10159574468085 0.553371428229772 0.919676701796297 GO:0030742 GTP-dependent protein binding 2/1692 20/18639 0.1 1.10159574468085 0.553371428229772 0.919676701796297 GO:0042288 MHC class I protein binding 2/1692 20/18639 0.1 1.10159574468085 0.553371428229772 0.919676701796297 GO:0140939 histone H4 methyltransferase activity 2/1692 20/18639 0.1 1.10159574468085 0.553371428229772 0.919676701796297 GO:0005125 cytokine activity 21/1692 234/18639 0.0897435897435897 0.988611565739225 0.555634732716105 0.921876193847341 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1692 43/18639 0.0930232558139535 1.02474022761009 0.556264018244906 0.921876193847341 GO:0046982 protein heterodimerization activity 33/1692 369/18639 0.0894308943089431 0.985166926137347 0.563177443087628 0.932019007926708 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1692 32/18639 0.09375 1.0327460106383 0.565308166088455 0.932917268474627 GO:0051059 NF-kappaB binding 3/1692 32/18639 0.09375 1.0327460106383 0.565308166088455 0.932917268474627 GO:0015297 antiporter activity 12/1692 135/18639 0.0888888888888889 0.97919621749409 0.574453270462822 0.936934238249405 GO:0019205 nucleobase-containing compound kinase activity 4/1692 44/18639 0.0909090909090909 1.00145067698259 0.574909947263567 0.936934238249405 GO:0016500 protein-hormone receptor activity 6/1692 67/18639 0.0895522388059701 0.986503651953001 0.575912445542871 0.936934238249405 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/1692 21/18639 0.0952380952380952 1.04913880445795 0.580409396722831 0.936934238249405 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1692 21/18639 0.0952380952380952 1.04913880445795 0.580409396722831 0.936934238249405 GO:0015125 bile acid transmembrane transporter activity 2/1692 21/18639 0.0952380952380952 1.04913880445795 0.580409396722831 0.936934238249405 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1692 21/18639 0.0952380952380952 1.04913880445795 0.580409396722831 0.936934238249405 GO:0061891 calcium ion sensor activity 2/1692 21/18639 0.0952380952380952 1.04913880445795 0.580409396722831 0.936934238249405 GO:0030296 protein tyrosine kinase activator activity 3/1692 33/18639 0.0909090909090909 1.00145067698259 0.586683200328056 0.936934238249405 GO:0071889 14-3-3 protein binding 3/1692 33/18639 0.0909090909090909 1.00145067698259 0.586683200328056 0.936934238249405 GO:0003777 microtubule motor activity 6/1692 68/18639 0.0882352941176471 0.971996245306633 0.590739705144105 0.936934238249405 GO:1990841 promoter-specific chromatin binding 6/1692 68/18639 0.0882352941176471 0.971996245306633 0.590739705144105 0.936934238249405 GO:0017124 SH3 domain binding 10/1692 115/18639 0.0869565217391304 0.95790934320074 0.604423292851315 0.936934238249405 GO:0035401 histone H3Y41 kinase activity 10/1692 115/18639 0.0869565217391304 0.95790934320074 0.604423292851315 0.936934238249405 GO:0140801 histone H2AXY142 kinase activity 10/1692 115/18639 0.0869565217391304 0.95790934320074 0.604423292851315 0.936934238249405 GO:0008649 rRNA methyltransferase activity 2/1692 22/18639 0.0909090909090909 1.00145067698259 0.606222248113047 0.936934238249405 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1692 22/18639 0.0909090909090909 1.00145067698259 0.606222248113047 0.936934238249405 GO:0050321 tau-protein kinase activity 2/1692 22/18639 0.0909090909090909 1.00145067698259 0.606222248113047 0.936934238249405 GO:0140035 ubiquitin-like protein reader activity 2/1692 22/18639 0.0909090909090909 1.00145067698259 0.606222248113047 0.936934238249405 GO:0008376 acetylgalactosaminyltransferase activity 3/1692 34/18639 0.0882352941176471 0.971996245306633 0.60737171910215 0.936934238249405 GO:0015020 glucuronosyltransferase activity 3/1692 34/18639 0.0882352941176471 0.971996245306633 0.60737171910215 0.936934238249405 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1692 34/18639 0.0882352941176471 0.971996245306633 0.60737171910215 0.936934238249405 GO:0030332 cyclin binding 3/1692 34/18639 0.0882352941176471 0.971996245306633 0.60737171910215 0.936934238249405 GO:0004180 carboxypeptidase activity 4/1692 46/18639 0.0869565217391304 0.95790934320074 0.610827442453284 0.936934238249405 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1692 46/18639 0.0869565217391304 0.95790934320074 0.610827442453284 0.936934238249405 GO:0015101 organic cation transmembrane transporter activity 7/1692 81/18639 0.0864197530864197 0.951996322563698 0.61097403946846 0.936934238249405 GO:0030971 receptor tyrosine kinase binding 7/1692 81/18639 0.0864197530864197 0.951996322563698 0.61097403946846 0.936934238249405 GO:0001094 TFIID-class transcription factor complex binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0003796 lysozyme activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0004090 carbonyl reductase (NADPH) activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0004935 adrenergic receptor activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0005031 tumor necrosis factor receptor activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0005131 growth hormone receptor binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0005337 nucleoside transmembrane transporter activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0016783 sulfurtransferase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0016868 intramolecular phosphotransferase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0031419 cobalamin binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0031720 haptoglobin binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0032356 oxidized DNA binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0035256 G protein-coupled glutamate receptor binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0042975 peroxisome proliferator activated receptor binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0043121 neurotrophin binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0045322 unmethylated CpG binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0051864 histone H3K36 demethylase activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0051880 G-quadruplex DNA binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0070097 delta-catenin binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0070513 death domain binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0097177 mitochondrial ribosome binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0098505 G-rich strand telomeric DNA binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:1905394 retromer complex binding 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:1990757 ubiquitin ligase activator activity 1/1692 10/18639 0.1 1.10159574468085 0.613990947618759 0.936934238249405 GO:0140101 catalytic activity, acting on a tRNA 12/1692 139/18639 0.0863309352517986 0.951017909076994 0.615942107617012 0.937476653432628 GO:0140767 enzyme-substrate adaptor activity 12/1692 139/18639 0.0863309352517986 0.951017909076994 0.615942107617012 0.937476653432628 GO:0000510 H3-H4 histone complex chaperone activity 13/1692 151/18639 0.0860927152317881 0.94839368747358 0.621258103879903 0.94069364956042 GO:0140584 chromatin extrusion motor activity 13/1692 151/18639 0.0860927152317881 0.94839368747358 0.621258103879903 0.94069364956042 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 13/1692 151/18639 0.0860927152317881 0.94839368747358 0.621258103879903 0.94069364956042 GO:0140849 ATP-dependent H2AZ histone chaperone activity 13/1692 151/18639 0.0860927152317881 0.94839368747358 0.621258103879903 0.94069364956042 GO:0016229 steroid dehydrogenase activity 3/1692 35/18639 0.0857142857142857 0.944224924012158 0.627357740067292 0.942391157939412 GO:0001784 phosphotyrosine residue binding 4/1692 47/18639 0.0851063829787234 0.937528293345405 0.628066342820378 0.942391157939412 GO:0005504 fatty acid binding 4/1692 47/18639 0.0851063829787234 0.937528293345405 0.628066342820378 0.942391157939412 GO:0140359 ABC-type transporter activity 4/1692 47/18639 0.0851063829787234 0.937528293345405 0.628066342820378 0.942391157939412 GO:0005158 insulin receptor binding 2/1692 23/18639 0.0869565217391304 0.95790934320074 0.630809481442052 0.942391157939412 GO:0031681 G-protein beta-subunit binding 2/1692 23/18639 0.0869565217391304 0.95790934320074 0.630809481442052 0.942391157939412 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1692 23/18639 0.0869565217391304 0.95790934320074 0.630809481442052 0.942391157939412 GO:0071617 lysophospholipid acyltransferase activity 2/1692 23/18639 0.0869565217391304 0.95790934320074 0.630809481442052 0.942391157939412 GO:0015616 DNA translocase activity 13/1692 152/18639 0.0855263157894737 0.942154255319149 0.630874608806123 0.942391157939412 GO:0140674 ATP-dependent histone chaperone activity 13/1692 152/18639 0.0855263157894737 0.942154255319149 0.630874608806123 0.942391157939412 GO:0140299 molecular sensor activity 6/1692 71/18639 0.0845070422535211 0.930925981420437 0.633520370046252 0.942391157939412 GO:0140713 histone chaperone activity 14/1692 164/18639 0.0853658536585366 0.940386611312922 0.635549114226541 0.942391157939412 GO:0016757 glycosyltransferase activity 23/1692 267/18639 0.0861423220973783 0.948940154593992 0.636026574208473 0.942391157939412 GO:0016798 hydrolase activity, acting on glycosyl bonds 11/1692 130/18639 0.0846153846153846 0.932119476268413 0.64160496831831 0.942391157939412 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1692 60/18639 0.0833333333333333 0.917996453900709 0.645397957834298 0.942391157939412 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1692 36/18639 0.0833333333333333 0.917996453900709 0.646630597748416 0.942391157939412 GO:0016829 lyase activity 17/1692 200/18639 0.085 0.936356382978723 0.648579384837051 0.942391157939412 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0005225 volume-sensitive anion channel activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0005536 D-glucose binding 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0019206 nucleoside kinase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0019215 intermediate filament binding 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0034511 U3 snoRNA binding 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0035252 UDP-xylosyltransferase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0042285 xylosyltransferase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0043522 leucine zipper domain binding 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0045294 alpha-catenin binding 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0047676 arachidonate-CoA ligase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0180030 inositol phosphate kinase activity 1/1692 11/18639 0.0909090909090909 1.00145067698259 0.649050656493581 0.942391157939412 GO:0004622 lysophospholipase activity 2/1692 24/18639 0.0833333333333333 0.917996453900709 0.654180776809954 0.942391157939412 GO:0030552 cAMP binding 2/1692 24/18639 0.0833333333333333 0.917996453900709 0.654180776809954 0.942391157939412 GO:0035254 glutamate receptor binding 4/1692 49/18639 0.0816326530612245 0.899261832392531 0.661045836333835 0.942391157939412 GO:0019213 deacetylase activity 3/1692 37/18639 0.0810810810810811 0.89318573893042 0.665184404903916 0.942391157939412 GO:0003697 single-stranded DNA binding 10/1692 121/18639 0.0826446280991736 0.910409706347811 0.668805182873753 0.942391157939412 GO:0003684 damaged DNA binding 6/1692 74/18639 0.0810810810810811 0.89318573893042 0.673553062961764 0.942391157939412 GO:0050660 flavin adenine dinucleotide binding 7/1692 86/18639 0.0813953488372093 0.896647699158832 0.674056658675479 0.942391157939412 GO:0004725 protein tyrosine phosphatase activity 8/1692 98/18639 0.0816326530612245 0.899261832392531 0.675269148346979 0.942391157939412 GO:0005537 D-mannose binding 2/1692 25/18639 0.08 0.881276595744681 0.676354153069029 0.942391157939412 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1692 50/18639 0.08 0.881276595744681 0.676771349790318 0.942391157939412 GO:0004222 metalloendopeptidase activity 9/1692 110/18639 0.0818181818181818 0.901305609284333 0.676941294838976 0.942391157939412 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 10/1692 122/18639 0.0819672131147541 0.902947331705615 0.6789195010961 0.942391157939412 GO:0000340 RNA 7-methylguanosine cap binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0003995 acyl-CoA dehydrogenase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0004000 adenosine deaminase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0004875 complement receptor activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0005025 transforming growth factor beta receptor activity, type I 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0005026 transforming growth factor beta receptor activity, type II 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0005049 nuclear export signal receptor activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0005095 GTPase inhibitor activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0005247 voltage-gated chloride channel activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0008179 adenylate cyclase binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0015132 prostaglandin transmembrane transporter activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0015166 polyol transmembrane transporter activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0015368 calcium:monoatomic cation antiporter activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0016361 activin receptor activity, type I 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0016362 activin receptor activity, type II 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0016801 hydrolase activity, acting on ether bonds 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0016803 ether hydrolase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0017002 activin receptor activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0017166 vinculin binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0031543 peptidyl-proline dioxygenase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0035197 siRNA binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0043047 single-stranded telomeric DNA binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0045295 gamma-catenin binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:1990459 transferrin receptor binding 1/1692 12/18639 0.0833333333333333 0.917996453900709 0.680927738800477 0.942391157939412 GO:0042887 amide transmembrane transporter activity 3/1692 38/18639 0.0789473684210526 0.86968085106383 0.683017541119032 0.944171306841015 GO:0008081 phosphoric diester hydrolase activity 7/1692 87/18639 0.0804597701149425 0.886341403766202 0.685873475908028 0.946419471687241 GO:0044183 protein folding chaperone 6/1692 75/18639 0.08 0.881276595744681 0.68625479989577 0.946419471687241 GO:0141108 transporter regulator activity 14/1692 170/18639 0.0823529411764706 0.907196495619524 0.688332300642447 0.948171691975235 GO:0016830 carbon-carbon lyase activity 4/1692 51/18639 0.0784313725490196 0.863996662494785 0.691981494827365 0.948584276082397 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1692 26/18639 0.0769230769230769 0.847381342062193 0.69735437578494 0.948584276082397 GO:0015216 purine nucleotide transmembrane transporter activity 2/1692 26/18639 0.0769230769230769 0.847381342062193 0.69735437578494 0.948584276082397 GO:0034237 protein kinase A regulatory subunit binding 2/1692 26/18639 0.0769230769230769 0.847381342062193 0.69735437578494 0.948584276082397 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1692 39/18639 0.0769230769230769 0.847381342062193 0.70013217054078 0.948584276082397 GO:0004536 DNA nuclease activity 5/1692 64/18639 0.078125 0.860621675531915 0.701384350333751 0.948584276082397 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/1692 89/18639 0.0786516853932584 0.866423619411905 0.708671726381092 0.948584276082397 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/1692 89/18639 0.0786516853932584 0.866423619411905 0.708671726381092 0.948584276082397 GO:0002161 aminoacyl-tRNA editing activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0004535 poly(A)-specific ribonuclease activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0005035 death receptor activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0005172 vascular endothelial growth factor receptor binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0008417 fucosyltransferase activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0009982 pseudouridine synthase activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0017154 semaphorin receptor activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0039706 co-receptor binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0043560 insulin receptor substrate binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0051011 microtubule minus-end binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0071714 icosanoid transmembrane transporter activity 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0097157 pre-mRNA intronic binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:1901338 catecholamine binding 1/1692 13/18639 0.0769230769230769 0.847381342062193 0.709910949513399 0.948584276082397 GO:0160215 deacylase activity 5/1692 65/18639 0.0769230769230769 0.847381342062193 0.714376234188918 0.948584276082397 GO:0015036 disulfide oxidoreductase activity 3/1692 40/18639 0.075 0.826196808510638 0.716533789878031 0.948584276082397 GO:0032451 demethylase activity 3/1692 40/18639 0.075 0.826196808510638 0.716533789878031 0.948584276082397 GO:0071949 FAD binding 3/1692 40/18639 0.075 0.826196808510638 0.716533789878031 0.948584276082397 GO:0005104 fibroblast growth factor receptor binding 2/1692 27/18639 0.0740740740740741 0.815996847911741 0.717211585250485 0.948584276082397 GO:0015252 proton channel activity 2/1692 27/18639 0.0740740740740741 0.815996847911741 0.717211585250485 0.948584276082397 GO:0035255 ionotropic glutamate receptor binding 2/1692 27/18639 0.0740740740740741 0.815996847911741 0.717211585250485 0.948584276082397 GO:0015171 amino acid transmembrane transporter activity 8/1692 102/18639 0.0784313725490196 0.863996662494785 0.718151931021068 0.948584276082397 GO:0140793 histone H2AXY142 phosphatase activity 7/1692 90/18639 0.0777777777777778 0.856796690307329 0.719647870422056 0.948584276082397 GO:0005246 calcium channel regulator activity 4/1692 53/18639 0.0754716981132075 0.831393014853473 0.720851398059038 0.948584276082397 GO:0003823 antigen binding 14/1692 174/18639 0.0804597701149425 0.886341403766202 0.720916497124079 0.948584276082397 GO:0004812 aminoacyl-tRNA ligase activity 3/1692 41/18639 0.0731707317073171 0.806045666839647 0.732230807147941 0.948584276082397 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/1692 41/18639 0.0731707317073171 0.806045666839647 0.732230807147941 0.948584276082397 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1692 41/18639 0.0731707317073171 0.806045666839647 0.732230807147941 0.948584276082397 GO:0017080 sodium channel regulator activity 3/1692 41/18639 0.0731707317073171 0.806045666839647 0.732230807147941 0.948584276082397 GO:0033293 monocarboxylic acid binding 6/1692 79/18639 0.0759493670886076 0.83665499596014 0.733750735919187 0.948584276082397 GO:0046906 tetrapyrrole binding 12/1692 152/18639 0.0789473684210526 0.86968085106383 0.73533209456117 0.948584276082397 GO:0016866 intramolecular transferase activity 2/1692 28/18639 0.0714285714285714 0.786854103343465 0.735960117755468 0.948584276082397 GO:0005344 oxygen carrier activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0015386 potassium:proton antiporter activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0016530 metallochaperone activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0019763 immunoglobulin receptor activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0030983 mismatched DNA binding 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0031404 chloride ion binding 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0032454 histone H3K9 demethylase activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0042813 Wnt receptor activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0043176 amine binding 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0061783 peptidoglycan muralytic activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0098599 palmitoyl hydrolase activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0098821 BMP receptor activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0098847 sequence-specific single stranded DNA binding 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:1901474 azole transmembrane transporter activity 1/1692 14/18639 0.0714285714285714 0.786854103343465 0.736262859393316 0.948584276082397 GO:0052689 carboxylic ester hydrolase activity 7/1692 92/18639 0.0760869565217391 0.838170675300648 0.740746433861144 0.9533155090765 GO:0008374 O-acyltransferase activity 4/1692 55/18639 0.0727272727272727 0.801160541586073 0.747666193293851 0.957407414792478 GO:0051213 dioxygenase activity 7/1692 93/18639 0.0752688172043011 0.829158087394189 0.750867776373036 0.957407414792478 GO:0020037 heme binding 11/1692 142/18639 0.0774647887323944 0.853348816302068 0.751887480703675 0.957407414792478 GO:0003785 actin monomer binding 2/1692 29/18639 0.0689655172413793 0.759721203228173 0.753637496363639 0.957407414792478 GO:0004181 metallocarboxypeptidase activity 2/1692 29/18639 0.0689655172413793 0.759721203228173 0.753637496363639 0.957407414792478 GO:0004629 phospholipase C activity 2/1692 29/18639 0.0689655172413793 0.759721203228173 0.753637496363639 0.957407414792478 GO:0099604 ligand-gated calcium channel activity 2/1692 29/18639 0.0689655172413793 0.759721203228173 0.753637496363639 0.957407414792478 GO:0000774 adenyl-nucleotide exchange factor activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0005041 low-density lipoprotein particle receptor activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0015116 sulfate transmembrane transporter activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0031386 protein tag activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0033130 acetylcholine receptor binding 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0047372 monoacylglycerol lipase activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0048531 beta-1,3-galactosyltransferase activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0050700 CARD domain binding 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0140776 protein-containing complex destabilizing activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0141047 molecular tag activity 1/1692 15/18639 0.0666666666666667 0.734397163120567 0.760222228086283 0.957407414792478 GO:0140996 histone H3 kinase activity 29/1692 357/18639 0.0812324929971989 0.894853686155313 0.76278431174984 0.959141169788293 GO:0016247 channel regulator activity 13/1692 168/18639 0.0773809523809524 0.852425278622087 0.765970149663143 0.959141169788293 GO:0004175 endopeptidase activity 33/1692 405/18639 0.0814814814814815 0.897596532702916 0.76903387131623 0.959141169788293 GO:0001965 G-protein alpha-subunit binding 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0015215 nucleotide transmembrane transporter activity 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0031624 ubiquitin conjugating enzyme binding 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0051721 protein phosphatase 2A binding 2/1692 30/18639 0.0666666666666667 0.734397163120567 0.770283570163167 0.959141169788293 GO:0016887 ATP hydrolysis activity 34/1692 417/18639 0.0815347721822542 0.898183580794939 0.770601959135756 0.959141169788293 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/1692 57/18639 0.0701754385964912 0.773049645390071 0.772463246076624 0.959141169788293 GO:0035173 histone kinase activity 29/1692 360/18639 0.0805555555555556 0.887396572104019 0.777760574081538 0.959141169788293 GO:0005085 guanyl-nucleotide exchange factor activity 18/1692 230/18639 0.0782608695652174 0.862118408880666 0.778869630301549 0.959141169788293 GO:0008236 serine-type peptidase activity 15/1692 194/18639 0.077319587628866 0.851749287124369 0.778906523679155 0.959141169788293 GO:0003688 DNA replication origin binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0005149 interleukin-1 receptor binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0008142 oxysterol binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0015378 sodium:chloride symporter activity 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0019841 retinol binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0030275 LRR domain binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0140328 floppase activity 1/1692 16/18639 0.0625 0.688497340425532 0.782006162261434 0.959141169788293 GO:0017147 Wnt-protein binding 2/1692 31/18639 0.0645161290322581 0.710706932052162 0.785939783375584 0.96195754736074 GO:0070273 phosphatidylinositol-4-phosphate binding 2/1692 31/18639 0.0645161290322581 0.710706932052162 0.785939783375584 0.96195754736074 GO:0004879 nuclear receptor activity 4/1692 59/18639 0.0677966101694915 0.746844572664984 0.795301280327899 0.971444615962078 GO:0099106 ion channel regulator activity 12/1692 160/18639 0.075 0.826196808510638 0.795344443025973 0.971444615962078 GO:0015106 bicarbonate transmembrane transporter activity 2/1692 32/18639 0.0625 0.688497340425532 0.800648557861392 0.972269547929474 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0004550 nucleoside diphosphate kinase activity 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0004659 prenyltransferase activity 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0030169 low-density lipoprotein particle binding 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0031489 myosin V binding 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0036041 long-chain fatty acid binding 1/1692 17/18639 0.0588235294117647 0.647997496871089 0.801812078249924 0.972269547929474 GO:0043539 protein serine/threonine kinase activator activity 5/1692 73/18639 0.0684931506849315 0.754517633343049 0.803887852740577 0.972936915066065 GO:0017171 serine hydrolase activity 15/1692 198/18639 0.0757575757575758 0.834542230818827 0.804018505982254 0.972936915066065 GO:0141003 histone H2AX kinase activity 28/1692 354/18639 0.0790960451977401 0.871318668109148 0.805096744563893 0.973239377430632 GO:0098531 ligand-modulated transcription factor activity 4/1692 60/18639 0.0666666666666667 0.734397163120567 0.806008660506013 0.973340365975915 GO:0035402 histone H3T11 kinase activity 19/1692 247/18639 0.0769230769230769 0.847381342062193 0.807298484418884 0.973897042291775 GO:0031406 carboxylic acid binding 14/1692 187/18639 0.0748663101604278 0.82472408692684 0.811294472844384 0.974033615176376 GO:0004679 AMP-activated protein kinase activity 19/1692 248/18639 0.0766129032258065 0.843964481811942 0.812599887956628 0.974033615176376 GO:0003678 DNA helicase activity 5/1692 74/18639 0.0675675675675676 0.744321449108683 0.813332402724549 0.974033615176376 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0003746 translation elongation factor activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0008308 voltage-gated monoatomic anion channel activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0015172 acidic amino acid transmembrane transporter activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0015373 monoatomic anion:sodium symporter activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0030228 lipoprotein particle receptor activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0031690 adrenergic receptor binding 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0032393 MHC class I receptor activity 1/1692 18/18639 0.0555555555555556 0.611997635933806 0.819819486884932 0.974033615176376 GO:0043177 organic acid binding 14/1692 189/18639 0.0740740740740741 0.815996847911741 0.823072188167546 0.974033615176376 GO:0030695 GTPase regulator activity 39/1692 489/18639 0.0797546012269939 0.878573293303746 0.825767554035861 0.974033615176376 GO:0015035 protein-disulfide reductase activity 2/1692 34/18639 0.0588235294117647 0.647997496871089 0.82739534043734 0.974033615176376 GO:0016831 carboxy-lyase activity 2/1692 34/18639 0.0588235294117647 0.647997496871089 0.82739534043734 0.974033615176376 GO:0051427 hormone receptor binding 2/1692 34/18639 0.0588235294117647 0.647997496871089 0.82739534043734 0.974033615176376 GO:0060589 nucleoside-triphosphatase regulator activity 39/1692 490/18639 0.0795918367346939 0.876780286582718 0.829368758998564 0.974033615176376 GO:0031490 chromatin DNA binding 9/1692 128/18639 0.0703125 0.774559507978723 0.831977096931706 0.974033615176376 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0008301 DNA binding, bending 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0015245 fatty acid transmembrane transporter activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0022821 solute:potassium antiporter activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0034987 immunoglobulin receptor binding 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0046527 glucosyltransferase activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0046624 sphingolipid transporter activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0140036 ubiquitin-modified protein reader activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0141147 intracellularly calcium-gated channel activity 1/1692 19/18639 0.0526315789473684 0.579787234042553 0.836191616641159 0.974033615176376 GO:0005506 iron ion binding 11/1692 154/18639 0.0714285714285714 0.786854103343465 0.836563565441145 0.974033615176376 GO:0005154 epidermal growth factor receptor binding 2/1692 35/18639 0.0571428571428571 0.629483282674772 0.839518831368858 0.974033615176376 GO:0005343 organic acid:sodium symporter activity 2/1692 35/18639 0.0571428571428571 0.629483282674772 0.839518831368858 0.974033615176376 GO:0043015 gamma-tubulin binding 2/1692 35/18639 0.0571428571428571 0.629483282674772 0.839518831368858 0.974033615176376 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 18/1692 243/18639 0.0740740740740741 0.815996847911741 0.84794761851014 0.974033615176376 GO:0004033 aldo-keto reductase (NADPH) activity 2/1692 36/18639 0.0555555555555556 0.611997635933806 0.850865198052413 0.974033615176376 GO:0004190 aspartic-type endopeptidase activity 2/1692 36/18639 0.0555555555555556 0.611997635933806 0.850865198052413 0.974033615176376 GO:0001614 purinergic nucleotide receptor activity 1/1692 20/18639 0.05 0.550797872340426 0.851076889715442 0.974033615176376 GO:0001972 retinoic acid binding 1/1692 20/18639 0.05 0.550797872340426 0.851076889715442 0.974033615176376 GO:0015095 magnesium ion transmembrane transporter activity 1/1692 20/18639 0.05 0.550797872340426 0.851076889715442 0.974033615176376 GO:0016004 phospholipase activator activity 1/1692 20/18639 0.05 0.550797872340426 0.851076889715442 0.974033615176376 GO:0016502 nucleotide receptor activity 1/1692 20/18639 0.05 0.550797872340426 0.851076889715442 0.974033615176376 GO:0004676 3-phosphoinositide-dependent protein kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0004711 ribosomal protein S6 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0035175 histone H3S10 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0035979 histone H2AXS139 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0044022 histone H3S28 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0044023 histone H4S1 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0044024 histone H2AS1 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0044025 histone H2BS14 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0072354 histone H3T3 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0072371 histone H2AS121 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0072518 Rho-dependent protein serine/threonine kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0140823 histone H2BS36 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0140855 histone H3S57 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0140995 histone H2A kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0140997 histone H4 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0140998 histone H2B kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:1990244 histone H2AT120 kinase activity 18/1692 245/18639 0.073469387755102 0.809335649153278 0.85695269135869 0.974033615176376 GO:0004677 DNA-dependent protein kinase activity 18/1692 246/18639 0.0731707317073171 0.806045666839647 0.861299620574511 0.974033615176376 GO:0140857 histone H3T45 kinase activity 18/1692 246/18639 0.0731707317073171 0.806045666839647 0.861299620574511 0.974033615176376 GO:0022829 wide pore channel activity 2/1692 37/18639 0.0540540540540541 0.595457159286947 0.861475529089471 0.974033615176376 GO:0030551 cyclic nucleotide binding 2/1692 37/18639 0.0540540540540541 0.595457159286947 0.861475529089471 0.974033615176376 GO:0070001 aspartic-type peptidase activity 2/1692 37/18639 0.0540540540540541 0.595457159286947 0.861475529089471 0.974033615176376 GO:0005096 GTPase activator activity 20/1692 271/18639 0.0738007380073801 0.812985789432362 0.862877190882079 0.974033615176376 GO:0005123 death receptor binding 1/1692 21/18639 0.0476190476190476 0.524569402228977 0.864610264365073 0.974033615176376 GO:0005248 voltage-gated sodium channel activity 1/1692 21/18639 0.0476190476190476 0.524569402228977 0.864610264365073 0.974033615176376 GO:0015174 basic amino acid transmembrane transporter activity 1/1692 21/18639 0.0476190476190476 0.524569402228977 0.864610264365073 0.974033615176376 GO:0035613 RNA stem-loop binding 1/1692 21/18639 0.0476190476190476 0.524569402228977 0.864610264365073 0.974033615176376 GO:0051428 peptide hormone receptor binding 1/1692 21/18639 0.0476190476190476 0.524569402228977 0.864610264365073 0.974033615176376 GO:0035403 histone H3T6 kinase activity 18/1692 247/18639 0.0728744939271255 0.80278232405892 0.865544251364036 0.974151815471975 GO:0005548 phospholipid transporter activity 4/1692 68/18639 0.0588235294117647 0.647997496871089 0.87609454931323 0.982244504621377 GO:0005243 gap junction channel activity 1/1692 22/18639 0.0454545454545455 0.500725338491296 0.87691445561517 0.982244504621377 GO:0008093 cytoskeletal anchor activity 1/1692 22/18639 0.0454545454545455 0.500725338491296 0.87691445561517 0.982244504621377 GO:0015377 chloride:monoatomic cation symporter activity 1/1692 22/18639 0.0454545454545455 0.500725338491296 0.87691445561517 0.982244504621377 GO:0140517 protein-RNA adaptor activity 1/1692 22/18639 0.0454545454545455 0.500725338491296 0.87691445561517 0.982244504621377 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/1692 39/18639 0.0512820512820513 0.564920894708129 0.880647034252534 0.985485966901645 GO:0005254 chloride channel activity 5/1692 83/18639 0.0602409638554217 0.663611894386055 0.882777930318297 0.986419628855225 GO:0004252 serine-type endopeptidase activity 12/1692 176/18639 0.0681818181818182 0.751088007736944 0.884605549892723 0.986419628855225 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 37/1692 484/18639 0.0764462809917355 0.842128978371725 0.88538665913583 0.986419628855225 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1692 23/18639 0.0434782608695652 0.47895467160037 0.888101045350311 0.986419628855225 GO:0005283 amino acid:sodium symporter activity 1/1692 23/18639 0.0434782608695652 0.47895467160037 0.888101045350311 0.986419628855225 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1692 23/18639 0.0434782608695652 0.47895467160037 0.888101045350311 0.986419628855225 GO:0099186 structural constituent of postsynapse 1/1692 23/18639 0.0434782608695652 0.47895467160037 0.888101045350311 0.986419628855225 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1692 70/18639 0.0571428571428571 0.629483282674772 0.889752893279962 0.986419628855225 GO:0170055 lipid transmembrane transporter activity 3/1692 56/18639 0.0535714285714286 0.590140577507599 0.89398739349821 0.986419628855225 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1692 41/18639 0.0487804878048781 0.537363777893098 0.897338612726662 0.986419628855225 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0005315 phosphate transmembrane transporter activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0005540 hyaluronic acid binding 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0015149 hexose transmembrane transporter activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0050699 WW domain binding 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0055056 D-glucose transmembrane transporter activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0060229 lipase activator activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0140612 DNA damage sensor activity 1/1692 24/18639 0.0416666666666667 0.458998226950355 0.898271491808588 0.986419628855225 GO:0001216 DNA-binding transcription activator activity 37/1692 491/18639 0.0753564154786151 0.830123066256446 0.903268373182215 0.986432660423263 GO:0017116 single-stranded DNA helicase activity 3/1692 58/18639 0.0517241379310345 0.56979090242113 0.907099605760904 0.986432660423263 GO:0000030 mannosyltransferase activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0001848 complement binding 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0003707 nuclear steroid receptor activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0015662 P-type ion transporter activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0017025 TBP-class protein binding 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0047617 fatty acyl-CoA hydrolase activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0140358 P-type transmembrane transporter activity 1/1692 25/18639 0.04 0.44063829787234 0.907518047589402 0.986432660423263 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/1692 130/18639 0.0615384615384615 0.677905073649754 0.912719195859188 0.989164888320182 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0004435 phosphatidylinositol phospholipase C activity 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0005112 Notch binding 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0005227 calcium-activated cation channel activity 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0015145 monosaccharide transmembrane transporter activity 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0016289 acyl-CoA hydrolase activity 1/1692 26/18639 0.0384615384615385 0.423690671031097 0.915924594461581 0.989164888320182 GO:0016790 thiolester hydrolase activity 2/1692 44/18639 0.0454545454545455 0.500725338491296 0.918339129312281 0.989952731139386 GO:0043014 alpha-tubulin binding 2/1692 44/18639 0.0454545454545455 0.500725338491296 0.918339129312281 0.989952731139386 GO:0008395 steroid hydroxylase activity 1/1692 27/18639 0.037037037037037 0.407998423955871 0.923567402508162 0.993765291160339 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/1692 27/18639 0.037037037037037 0.407998423955871 0.923567402508162 0.993765291160339 GO:0046943 carboxylic acid transmembrane transporter activity 12/1692 188/18639 0.0638297872340425 0.703146220009054 0.928356208479797 0.996569180044852 GO:0005242 inward rectifier potassium channel activity 1/1692 28/18639 0.0357142857142857 0.393427051671733 0.930515820461965 0.996569180044852 GO:0051119 sugar transmembrane transporter activity 1/1692 28/18639 0.0357142857142857 0.393427051671733 0.930515820461965 0.996569180044852 GO:0141052 histone H3 demethylase activity 1/1692 28/18639 0.0357142857142857 0.393427051671733 0.930515820461965 0.996569180044852 GO:0015108 chloride transmembrane transporter activity 7/1692 121/18639 0.0578512396694215 0.637286794443468 0.930825774477811 0.996569180044852 GO:0005342 organic acid transmembrane transporter activity 12/1692 189/18639 0.0634920634920635 0.699425869638636 0.931262093352551 0.996569180044852 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1692 29/18639 0.0344827586206897 0.379860601614087 0.936832903465477 0.999798966005391 GO:0005416 amino acid:monoatomic cation symporter activity 1/1692 29/18639 0.0344827586206897 0.379860601614087 0.936832903465477 0.999798966005391 GO:0097472 cyclin-dependent protein kinase activity 1/1692 29/18639 0.0344827586206897 0.379860601614087 0.936832903465477 0.999798966005391 GO:0004620 phospholipase activity 6/1692 109/18639 0.055045871559633 0.606382978723404 0.938277508036809 0.999999999872018 GO:0036121 double-stranded DNA helicase activity 2/1692 48/18639 0.0416666666666667 0.458998226950355 0.940104393616506 0.999999999872018 GO:0038187 pattern recognition receptor activity 2/1692 48/18639 0.0416666666666667 0.458998226950355 0.940104393616506 0.999999999872018 GO:0022839 monoatomic ion-gated channel activity 1/1692 30/18639 0.0333333333333333 0.367198581560284 0.942575983924177 0.999999999872018 GO:0032452 histone demethylase activity 1/1692 30/18639 0.0333333333333333 0.367198581560284 0.942575983924177 0.999999999872018 GO:0098918 structural constituent of synapse 1/1692 30/18639 0.0333333333333333 0.367198581560284 0.942575983924177 0.999999999872018 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1692 31/18639 0.032258064516129 0.355353466026081 0.94779719060913 0.999999999872018 GO:0140457 protein demethylase activity 1/1692 31/18639 0.032258064516129 0.355353466026081 0.94779719060913 0.999999999872018 GO:0015605 organophosphate ester transmembrane transporter activity 2/1692 50/18639 0.04 0.44063829787234 0.948799030312636 0.999999999872018 GO:0005272 sodium channel activity 2/1692 51/18639 0.0392156862745098 0.431998331247393 0.952681236922347 0.999999999872018 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/1692 52/18639 0.0384615384615385 0.423690671031097 0.956281062499963 0.999999999872018 GO:0019239 deaminase activity 1/1692 33/18639 0.0303030303030303 0.333816892327531 0.956859269017183 0.999999999872018 GO:0019956 chemokine binding 1/1692 33/18639 0.0303030303030303 0.333816892327531 0.956859269017183 0.999999999872018 GO:0016782 transferase activity, transferring sulphur-containing groups 3/1692 70/18639 0.0428571428571429 0.472112462006079 0.959251810554953 0.999999999872018 GO:0005544 calcium-dependent phospholipid binding 2/1692 53/18639 0.0377358490566038 0.415696507426736 0.959617745364772 0.999999999872018 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1692 53/18639 0.0377358490566038 0.415696507426736 0.959617745364772 0.999999999872018 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1692 34/18639 0.0294117647058824 0.323998748435544 0.960782418368088 0.999999999872018 GO:0019825 oxygen binding 1/1692 34/18639 0.0294117647058824 0.323998748435544 0.960782418368088 0.999999999872018 GO:0090482 vitamin transmembrane transporter activity 1/1692 34/18639 0.0294117647058824 0.323998748435544 0.960782418368088 0.999999999872018 GO:0005179 hormone activity 7/1692 132/18639 0.053030303030303 0.584179561573179 0.961165082749784 0.999999999872018 GO:0005253 monoatomic anion channel activity 5/1692 103/18639 0.0485436893203883 0.534755215864491 0.962799563900447 0.999999999872018 GO:0015081 sodium ion transmembrane transporter activity 9/1692 164/18639 0.0548780487804878 0.604534250129735 0.967204376202136 0.999999999872018 GO:0030280 structural constituent of skin epidermis 1/1692 37/18639 0.027027027027027 0.297728579643473 0.97053905140454 0.999999999872018 GO:0036002 pre-mRNA binding 2/1692 59/18639 0.0338983050847458 0.373422286332492 0.975049219848308 0.999999999872018 GO:0070888 E-box binding 2/1692 59/18639 0.0338983050847458 0.373422286332492 0.975049219848308 0.999999999872018 GO:0008514 organic anion transmembrane transporter activity 16/1692 269/18639 0.0594795539033457 0.655224234754409 0.977196256566763 0.999999999872018 GO:0015144 carbohydrate transmembrane transporter activity 1/1692 40/18639 0.025 0.275398936170213 0.977869479920991 0.999999999872018 GO:0071855 neuropeptide receptor binding 1/1692 40/18639 0.025 0.275398936170213 0.977869479920991 0.999999999872018 GO:0015370 solute:sodium symporter activity 3/1692 79/18639 0.0379746835443038 0.41832749798007 0.978682557424402 0.999999999872018 GO:0008227 G protein-coupled amine receptor activity 1/1692 41/18639 0.024390243902439 0.268681888946549 0.979882751600849 0.999999999872018 GO:0015291 secondary active transmembrane transporter activity 17/1692 287/18639 0.0592334494773519 0.652513158870191 0.98107973389143 0.999999999872018 GO:0016298 lipase activity 6/1692 130/18639 0.0461538461538462 0.508428805237316 0.981558063471046 0.999999999872018 GO:0015085 calcium ion transmembrane transporter activity 7/1692 147/18639 0.0476190476190476 0.524569402228977 0.983246534496437 0.999999999872018 GO:0005245 voltage-gated calcium channel activity 1/1692 43/18639 0.0232558139534884 0.256185056902524 0.983376767325195 0.999999999872018 GO:0015294 solute:monoatomic cation symporter activity 5/1692 116/18639 0.0431034482758621 0.474825752017608 0.983495297560648 0.999999999872018 GO:0008509 monoatomic anion transmembrane transporter activity 7/1692 149/18639 0.0469798657718121 0.517528202199058 0.985085459830339 0.999999999872018 GO:0015103 inorganic anion transmembrane transporter activity 8/1692 165/18639 0.0484848484848485 0.534107027724049 0.985753951715747 0.999999999872018 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/1692 45/18639 0.0222222222222222 0.244799054373522 0.986264229085758 0.999999999872018 GO:0140303 intramembrane lipid transporter activity 1/1692 45/18639 0.0222222222222222 0.244799054373522 0.986264229085758 0.999999999872018 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1692 46/18639 0.0217391304347826 0.239477335800185 0.987514144348042 0.999999999872018 GO:0061749 forked DNA-dependent helicase activity 1/1692 47/18639 0.0212765957446809 0.234382073336351 0.988650382059176 0.999999999872018 GO:0099095 ligand-gated monoatomic anion channel activity 1/1692 47/18639 0.0212765957446809 0.234382073336351 0.988650382059176 0.999999999872018 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1692 47/18639 0.0212765957446809 0.234382073336351 0.988650382059176 0.999999999872018 GO:0008528 G protein-coupled peptide receptor activity 5/1692 122/18639 0.040983606557377 0.451473665852808 0.988819898289206 0.999999999872018 GO:0009378 four-way junction helicase activity 1/1692 48/18639 0.0208333333333333 0.229499113475177 0.989683275430296 0.999999999872018 GO:0043138 3'-5' DNA helicase activity 1/1692 48/18639 0.0208333333333333 0.229499113475177 0.989683275430296 0.999999999872018 GO:0016763 pentosyltransferase activity 1/1692 49/18639 0.0204081632653061 0.224815458098133 0.990622218896056 0.999999999872018 GO:0016597 amino acid binding 1/1692 51/18639 0.0196078431372549 0.215999165623696 0.992251643685634 0.999999999872018 GO:0001653 peptide receptor activity 5/1692 128/18639 0.0390625 0.430310837765957 0.992487682929835 0.999999999872018 GO:0008146 sulfotransferase activity 1/1692 53/18639 0.0188679245283019 0.207848253713368 0.993598087734354 0.999999999872018 GO:0005262 calcium channel activity 5/1692 131/18639 0.0381679389312977 0.420456391099561 0.993859429283718 0.999999999872018 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 8/1692 181/18639 0.0441988950276243 0.486893146820266 0.994350765814515 0.999999999872018 GO:0005249 voltage-gated potassium channel activity 3/1692 98/18639 0.0306122448979592 0.337223187147199 0.994901023411757 0.999999999872018 GO:0030165 PDZ domain binding 2/1692 83/18639 0.0240963855421687 0.265444757754422 0.99660036402405 0.999999999872018 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 13/1692 268/18639 0.0485074626865672 0.534356144807876 0.996893314953023 0.999999999872018 GO:0015293 symporter activity 5/1692 146/18639 0.0342465753424658 0.377258816671524 0.997815801309575 0.999999999872018 GO:0046873 metal ion transmembrane transporter activity 25/1692 450/18639 0.0555555555555556 0.611997635933806 0.998053394695557 0.999999999872018 GO:0001217 DNA-binding transcription repressor activity 13/1692 278/18639 0.0467625899280576 0.515134700750038 0.998183990734333 0.999999999872018 GO:0099094 ligand-gated monoatomic cation channel activity 4/1692 136/18639 0.0294117647058824 0.323998748435544 0.998804171073182 0.999999999872018 GO:0003730 mRNA 3'-UTR binding 11/1692 262/18639 0.0419847328244275 0.462502030209518 0.999228289347843 0.999999999872018 GO:0005267 potassium channel activity 3/1692 124/18639 0.0241935483870968 0.266515099519561 0.999348088230099 0.999999999872018 GO:0004497 monooxygenase activity 2/1692 106/18639 0.0188679245283019 0.207848253713368 0.999529740027562 0.999999999872018 GO:0015079 potassium ion transmembrane transporter activity 4/1692 160/18639 0.025 0.275398936170213 0.999810791285431 0.999999999872018 GO:0022843 voltage-gated monoatomic cation channel activity 3/1692 143/18639 0.020979020979021 0.231104002380598 0.999862305767725 0.999999999872018 GO:0030527 structural constituent of chromatin 1/1692 98/18639 0.0102040816326531 0.112407729049066 0.999913187147786 0.999999999872018 GO:0005244 voltage-gated monoatomic ion channel activity 4/1692 173/18639 0.023121387283237 0.254704218423318 0.999932171695312 0.999999999872018 GO:0022832 voltage-gated channel activity 4/1692 175/18639 0.0228571428571429 0.251793313069909 0.999942159645816 0.999999999872018 GO:0015276 ligand-gated monoatomic ion channel activity 4/1692 186/18639 0.021505376344086 0.236902310684054 0.99997606906207 0.999999999872018 GO:0022834 ligand-gated channel activity 4/1692 188/18639 0.0212765957446809 0.234382073336351 0.999979639318866 0.999999999872018 GO:0005261 monoatomic cation channel activity 10/1692 341/18639 0.0293255131964809 0.323048605478255 0.999998586417832 0.999999999872018 GO:0005216 monoatomic ion channel activity 14/1692 448/18639 0.03125 0.344248670212766 0.999999871669453 0.999999999872018 GO:0045182 translation regulator activity 8/1692 356/18639 0.0224719101123595 0.247549605546259 0.99999997400752 0.999999999872018 GO:0022836 gated channel activity 6/1692 318/18639 0.0188679245283019 0.207848253713368 0.999999981646121 0.999999999872018 GO:0030371 translation repressor activity 4/1692 329/18639 0.0121580547112462 0.133932613335058 0.999999999872018 0.999999999872018