category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	104/1157	222/9376	3.7963356615042	RPL13A/RPL10/RPS26/RPS8/RPL18A/RPS11/RPS28/RPL13/RPS27/RPL37A/RPL28/RPL8/RPL36/RPS15/RPS14/RPS2/RPLP0/RPL23/RPL41/RPL11/RPL18/RPLP2/RPS16/RPS20/RPL7/RPS18/RPL21/RPL3/RPS9/RPL29/RPL35/RPL27A/RPS6/RPS5/RPS27A/RPL34/RPL35A/RPL19/RPS12/RPL5/RPS3/UBA52/RPS4X/RPL31/RPL15/RPL10A/RPLP1/RPL12/RPS3A/RACK1/RPL6/RPSA/RPS29/RPS19/RPS24/RPS13/RPL7A/RPS25/RPL37/RPL9/RPL32/RPL24/RPL30/RPL22/RPS23/RPL14/MRPL22/MRPL17/RPL39/MRPL14/MRPL27/MRPS16/MRPL16/RPL36AL/RPL4/MRPS26/RPL23A/RPS15A/MRPL52/MRPS12/MRPL49/MRPL45/MRPL1/FAU/RPL38/MRPL43/RPL26L1/RPS7/MRPL46/MRPS7/MRPS27/MRPL11/RPS4Y1/MRPL40/MRPL23/MRPS33/MRPL21/MRPS9/MRPL4/MRPL36/MRPL12/MRPS18A/MRPS11/MRPS14	15.8198791626712
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	89/1157	238/9376	3.03038138332256	RPL13A/RPL10/RPS26/RPS8/RPL18A/RPS11/RPS28/RPL13/RPS27/RPL37A/RPL28/RPL8/RPL36/RPS15/RPS14/RPS2/RPLP0/RPL23/RPL41/RPL11/RPL18/RPLP2/RPS16/RPS20/RPL7/RPS18/RPL21/RPL3/RPS9/RPL29/RPL35/RPL27A/RPS6/RPS5/RPS27A/RPL34/RPL35A/RPL19/RPS12/RPL5/RPS3/UBA52/RPS4X/RPL31/RPL15/RPL10A/RPLP1/RPL12/RPS3A/RPL6/RPSA/RPS29/RPS19/C1R/RPS24/EGFR/RPS13/RPL7A/RPS25/RPL37/RPL9/RPL32/RPL24/RPL30/MAPK14/RPL22/RPS23/CFD/RELA/RPL14/PIK3CA/RPL39/NFKBIB/RPL36AL/RPL4/IRF3/RPL23A/RPS15A/PRKCB/IKBKG/FGG/FAU/VWF/RPL38/RPL26L1/RPS7/RPS4Y1/PLCG2/TLR7	11.9037377886096
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	71/1157	308/9376	1.86806451974991	MT-CYB/MT-CO2/MT-CO3/TGM2/MT-ND3/COX7A1/POLR2L/COX4I1/NDUFA5/MT-ATP6/DCTN5/ATP5F1E/POLR2J/COX6C/MT-ND4/PSMA7/BECN1/POLR2D/NDUFS4/NDUFB6/CREB1/NDUFA10/NDUFAB1/POLR2H/TUBA3E/HDAC2/IFT57/ATG13/PSMD3/CREB3/CREBBP/CREB3L1/ATP5F1D/MT-ND1/COX7A2L/TAF4/WIPI2/SDHA/PSMB3/NDUFA2/PSMB7/HIP1/ADRM1/ATP5MC1/PSMB4/PSMB5/AP2A2/GPX8/SLC25A6/PSMC1/CLTB/ATG14/MAP3K5/MT-ATP8/DCTN2/HDAC1/PSMD1/RCOR1/NDUFS3/ATP5PO/ACTR1A/POLR2F/NDUFA13/NDUFA4L2/TP53/PSMC5/DCTN1/NDUFA8/GPX3/AP2A1/NDUFB11	5.81185051921081
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	58/1157	235/9376	2.00006620202652	MT-CYB/MT-CO2/MT-CO3/MT-ND3/RPS6/COX7A1/COX4I1/ATP5ME/NDUFA5/MT-ATP6/MAPK14/ACTG1/ATP5F1E/ARID1A/COX6C/MT-ND4/COA3/NDUFS4/NDUFB6/CREB1/SMARCC1/NDUFA10/NDUFAB1/SMARCD2/SMARCB1/COA5/FRS2/SMARCC2/CPT2/COX20/CNR1/NDUFAF1/COX16/CREB3/CREB3L1/ATP5F1D/MT-ND1/COX7A2L/RPS6KA3/SDHA/COA7/SMARCD1/NDUFA2/ATP5MC1/TSC2/BMP8B/NDUFAF6/MAP3K5/MT-ATP8/NDUFS3/ATP5PO/SMARCA2/SMARCA4/NDUFA13/CPT1A/NDUFA4L2/NDUFA8/NDUFB11	5.82517067249882
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	49/1157	203/9376	1.95606950198194	FN1/FLT1/MYL9/CAV1/COL6A3/EGFR/KDR/ITGB8/PXN/ITGA1/COL6A2/ACTG1/LAMA4/PIK3CA/SRC/TNXB/ELK1/COL4A2/PDPK1/CCND3/COL1A1/ARHGAP5/ITGB1/EMP2/CRKL/PRKCB/PARVA/COL4A1/FLNA/PTK2/PIP5K1A/VWF/LAMB3/CAPN2/ITGB7/CAV2/AKT2/PAK4/LAMA3/PDGFA/CRK/SHC1/COL1A2/FYN/VTN/ITGA3/PARVB/ILK/PPP1R12C	5.16683525617717
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	46/1157	205/9376	1.81839492379366	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/GAPDH/COX4I1/NDUFA5/MMP2/MT-ATP6/MAPK14/ATP5F1E/RELA/PIK3CA/GFPT1/COX6C/MT-ND4/NDUFS4/NDUFB6/COL1A1/NDUFA10/NDUFAB1/PDHA1/PRKCB/CPT2/ATP5F1D/MT-ND1/COX7A2L/SLC2A1/SDHA/NDUFA2/INSR/PTPA/ATP5MC1/AKT2/G6PD/SLC25A6/MT-ATP8/COL1A2/PDHB/NDUFS3/ATP5PO/NDUFA13/NDUFA4L2/NDUFA8/NDUFB11	4.44502633360768
NA	NA	hsa04518	Integrin signaling	37/1157	154/9376	1.94699682340132	FN1/FLT1/FERMT2/COL6A3/FBN1/EGFR/KDR/ITGB8/PXN/ITGA1/COL6A2/ACTG1/LAMA4/PIK3CA/SRC/TNXB/COL4A2/CCND3/COL1A1/ITGB1/LIMS2/PARVA/COL4A1/FGG/FLNA/PTK2/VWF/LAMB3/ITGB7/AKT2/LAMA3/PDGFA/COL1A2/VTN/ITGA3/PARVB/ILK	4.44568974689714
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	30/1157	117/9376	2.07787602774638	UCHL5/ACTG1/SS18/VPS72/ARID1A/CHRAC1/SMARCC1/RBBP7/SMARCD2/SMARCB1/SMARCC2/KAT5/HDAC2/BICRAL/BCL7C/POLE3/BRD8/MTA2/SMARCD1/YY1/SMARCA5/PHF10/GATAD2B/BAZ1B/BAZ2B/HDAC1/SMARCA2/SMARCA4/INO80E/MTA3	4.40172118084817
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/1157	227/9376	1.64216281664185	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/EGFR/COX4I1/NDUFA5/MT-ATP6/MAPK14/ATP5F1E/RELA/PIK3CA/MGST2/SRC/COX6C/MT-ND4/ARAF/SLC26A2/PDPK1/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/KEAP1/GSTA1/IKBKG/ATP5F1D/MT-ND1/COX7A2L/PTK2/SDHA/PTPN11/NDUFA2/ATP5MC1/MAP2K2/AKT2/SLC25A6/MAP3K5/MT-ATP8/NDUFS3/ATP5PO/NDUFA13/NDUFA4L2/NDUFA8/NDUFB11	3.67463406800056
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1157	63/9376	2.31534757377454	POLR2L/RFC2/POLR2J/CUL4B/POLR2D/POLR2H/ERCC3/CETN2/CDK7/POLE3/RPA2/DDB2/UVSSA/POLR2F/DDB1/ERCC4/XPA/RPA3	3.93014730842714
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/1157	275/9376	1.56180718158246	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/CAV1/COX4I1/NDUFA5/MT-ATP6/MAPK14/ATP5F1E/PIK3CA/COX6C/MT-ND4/PSMA7/PPP3CA/NDUFS4/NDUFB6/CREB1/NOTCH1/NDUFA10/NDUFAB1/PPP3CB/TUBA3E/CSNK2B/PSMD3/CREB3/CREB3L1/ATP5F1D/MT-ND1/CSNK2A2/COX7A2L/SDHA/PSMB3/NDUFA2/PSMB7/ADRM1/ATP5MC1/CAV2/PSMB4/PSMB5/SLC25A6/PSMC1/MT-ATP8/PSMD1/FYN/NDUFS3/ATP5PO/NDUFA13/NDUFA4L2/PSMC5/NDUFA8/NDUFB11	3.54774097285366
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	70/1157	388/9376	1.46201071024423	MT-CYB/MT-CO2/MT-CO3/MT-ND3/DKK1/COX7A1/GAPDH/COX4I1/NDUFA5/WNT4/MT-ATP6/ATP5F1E/RELA/PIK3CA/WNT5A/COX6C/MT-ND4/PSMA7/ARAF/CAPN1/BECN1/PPP3CA/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/PPP3CB/TUBA3E/SLC39A7/IKBKG/CSNK2B/ATG13/PSMD3/BACE1/ATP5F1D/MT-ND1/CSNK2A2/COX7A2L/WIPI2/SDHA/PSMB3/DVL2/NDUFA2/SLC39A9/PSMB7/INSR/CAPN2/ADRM1/ATP5MC1/FADD/MAP2K2/PSMB4/PSMB5/AKT2/SLC25A6/PSMC1/ATG14/HSD17B10/MAP3K5/MT-ATP8/APH1B/PSMD1/NDUFS3/ATP5PO/NDUFA13/WNT10B/NDUFA4L2/PSMC5/NDUFA8/NDUFB11	3.48721883559184
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/1157	138/9376	1.82040008517781	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/ATP5ME/NDUFA5/MT-ATP6/ATP5F1E/COX6C/MT-ND4/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/ATP5F1D/MT-ND1/COX7A2L/SDHA/NDUFA2/ATP5MC1/ATP6V1E1/ATP6V0D1/MT-ATP8/NDUFS3/ATP5PO/NDUFA13/NDUFA4L2/NDUFA8/NDUFB11	3.64266378861767
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/1157	480/9376	1.40126764621147	MT-CYB/MT-CO2/MT-CO3/MT-ND3/DKK1/RPS27A/COX7A1/UBA52/COX4I1/NDUFA5/WNT4/MT-ATP6/MAPK14/DCTN5/ATP5F1E/RELA/BAK1/MFN2/WNT5A/COX6C/MT-ND4/PSMA7/ARAF/CAPN1/BECN1/PPP3CA/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/ZFYVE1/PPP3CB/PRKCB/TUBA3E/IFT57/CSNK2B/ATG13/PSMD3/VCP/ATP5F1D/MT-ND1/CSNK2A2/COX7A2L/WIPI2/SDHA/WDR41/PSMB3/DVL2/NDUFA2/PSMB7/HIP1/CCS/CAPN2/TOMM40/ADRM1/ATP5MC1/FADD/MAP2K2/UBE2L3/PSMB4/PSMB5/GPX8/VAPB/SLC25A6/PSMC1/ATG14/HSD17B10/MAP3K5/MT-ATP8/DCTN2/PSMD1/NDUFS3/ATP5PO/ACTR1A/NDUFA13/WNT10B/NDUFA4L2/PSMC5/DCTN1/NDUFA8/GPX3/OPTN/NDUFB11	3.38610330345477
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	16/1157	56/9376	2.31534757377454	MAGT1/DDOST/ALG5/MAN1B1/DHRSX/MGAT4B/MAN2A1/SRD5A3/STT3A/ALG3/DPAGT1/ALG10B/TUSC3/DPM2/GANAB/MAN2A2	3.70398665098557
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	21/1157	83/9376	2.05033791171601	BMI1/DCAF7/TFDP1/CBX4/RBBP7/FOXK1/RING1/EZH1/HDAC2/CSNK2B/CREBBP/FOXK2/CBX6/YY1/PCGF1/YAF2/HDAC1/SFMBT1/BCOR/BAP1/WDR5	3.60605998399592
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/1157	46/9376	2.46634850249897	PSME3/PSMA7/PSMF1/PSMD3/PSMB3/PSMB7/ADRM1/PSMB4/PSMB5/PSMC1/PSME1/PSMB8/PSMD1/PSMC5	3.74040062949298
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/1157	268/9376	1.54212515641327	MT-CYB/MT-CO2/MT-CO3/MT-ND3/RPS27A/COX7A1/UBA52/COX4I1/NDUFA5/MT-ATP6/ATP5F1E/MFN2/MAOA/COX6C/MT-ND4/PSMA7/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/KEAP1/TUBA3E/SLC39A7/PSMD3/MAOB/ATP5F1D/MT-ND1/COX7A2L/SDHA/PSMB3/NDUFA2/SLC39A9/PSMB7/ADRM1/ATP5MC1/UBE2L3/PSMB4/PSMB5/SLC25A6/PSMC1/MAP3K5/MT-ATP8/PSMD1/NDUFS3/ATP5PO/NDUFA13/NDUFA4L2/TP53/PSMC5/NDUFA8/NDUFB11	3.37830047265369
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/1157	368/9376	1.45338393897261	MT-CYB/MT-CO2/MT-CO3/MT-ND3/COX7A1/COX4I1/NDUFA5/MT-ATP6/MAPK14/SEC13/DCTN5/ACTG1/ATP5F1E/COX6C/MT-ND4/PSMA7/BECN1/PPP3CA/NDUFS4/GLE1/NDUFB6/NDUFA10/NDUFAB1/PPP3CB/TUBA3E/HDAC6/ATG13/PSMD3/VCP/ATP5F1D/MT-ND1/COX7A2L/WIPI2/SDHA/WDR41/PSMB3/NDUFA2/PSMB7/CCS/TOMM40/NUP37/ADRM1/ATP5MC1/PSMB4/PSMB5/GPX8/VAPB/PSMC1/ATG14/MAP3K5/MT-ATP8/DCTN2/PSMD1/NDUFS3/UBQLN4/ATP5PO/ACTR1A/NDUFA13/NDUFA4L2/TP53/PSMC5/DCTN1/NDUFA8/GPX3/OPTN/NDUFB11	3.32903743874388
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/1157	23/9376	3.17101950321296	PCYOX1/FNTA/GGPS1/ICMT/RCE1/ACAT1/PDSS2/MVD/FDPS	3.91106472479895
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1157	122/9376	1.7934454567352	WNT4/MED13L/FOXO1/ACTG1/DIO2/PIK3CA/SRC/PDPK1/NOTCH1/MED4/NCOA1/PRKCB/HDAC2/HDAC3/CREBBP/SLC2A1/RXRB/MAP2K2/TSC2/AKT2/BMP4/PFKP/PLCG2/HDAC1/RXRA/TP53/PFKL	3.30959668529821
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	19/1157	77/9376	1.99961835916892	GAB2/RELA/PIK3CA/BAK1/ARAF/CTBP2/CRKL/HDAC2/IKBKG/PTPN11/DDB2/MAP2K2/AKT2/STAT5B/CDK4/CRK/SHC1/HDAC1/TP53	3.30448884411536
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	59/1157	333/9376	1.4357936155689	FN1/HLA-E/COL6A3/EGFR/HLA-G/WNT4/ITGB8/PXN/FOXO1/ITGA1/COL6A2/RELA/LAMA4/PIK3CA/BAK1/WNT5A/TNXB/COL4A2/CCND3/CREB1/COL1A1/IRF3/NOTCH1/TRADD/ITGB1/HDAC2/IKBKG/PPP2R5A/COL4A1/CREB3/CREBBP/CREB3L1/MFNG/PTK2/VWF/TADA3/LAMB3/DVL2/PRKCI/ITGB7/FADD/MAP2K2/TSC2/AKT2/TCF7/PPP2R5B/TCF7L2/CDK4/LAMA3/PSMC1/ATP6V1E1/ATP6V0D1/HDAC1/COL1A2/VTN/ITGA3/WNT10B/TP53/TUBG1	3.03801240083331
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/1157	31/9376	2.61410209942287	SRP19/SEC62/SRP14/BAG6/SEC11C/SRP68/OXA1L/SEC61A1/SPCS1/SRP72	3.37726410290301
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	39/1157	204/9376	1.54923992068738	FN1/LUM/TIMP3/DCN/RPS6/CAV1/CD63/EGFR/KDR/WNT4/MMP2/PXN/MAPK14/ACTG1/PIK3CA/SRC/WNT5A/ARAF/ELK1/PDPK1/COL1A1/ARHGEF1/ITGB1/FRS2/PRKCB/HSPG2/FLNA/PTK2/PTPN11/MAP2K2/CAV2/TIAM1/AKT2/PLCG2/COL1A2/VTN/WNT10B/TP53/PPP1R12C	2.97569204448941
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/1157	63/9376	2.05808673224404	DLST/ALDH7A1/PLOD1/EHMT2/NSD3/EZH1/HADH/SETD7/KMT5B/ALDH9A1/ACAT1/ECHS1/KMT2B/PLOD3/SETD1B/GCDH	3.16147367108319
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	24/1157	110/9376	1.76808360179147	FLT1/TIMP1/SERPINE1/RPS6/ELOB/GAPDH/EGFR/HK1/RELA/PIK3CA/EGLN1/EIF4E2/PDHA1/PRKCB/CREBBP/SLC2A1/INSR/MAP2K2/AKT2/EPAS1/PFKP/PLCG2/PDHB/PFKL	3.04019552441064
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	23/1157	106/9376	1.75835358197029	GSTP1/IL1R2/EGFR/ZEB1/FOXO1/RELA/PIK3CA/ARAF/PDPK1/CREB1/SPINT1/FOLR2/IKBKG/CREB3/CREBBP/CREB3L1/MAP2K2/AKT2/TCF7/TCF7L2/PDGFA/TP53/SLC46A1	2.94596535687915
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1157	43/9376	2.26150228136118	ACAA2/ALDH7A1/CPT2/ECI2/HADH/ALDH9A1/ACAT1/ECHS1/ACADS/CPT1A/GCDH/ACAA1	3.11067373741682
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/1157	170/9376	1.57307438100564	GSTP1/EGFR/WNT4/ACTG1/PIK3CA/BAK1/MGST2/WNT5A/ARID1A/ARAF/ELK1/SMARCC1/SMARCD2/SMARCB1/KEAP1/SMARCC2/PRKCB/GSTA1/SMARCD1/DVL2/DDB2/MAP2K2/AKT2/PHF10/TCF7/TCF7L2/CDK4/PLCG2/SHC1/SMARCA2/SMARCA4/WNT10B/TP53	2.82906415976003
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	45/1157	250/9376	1.45866897147796	CAV1/HLA-E/EGFR/HLA-G/EHD2/ARPC1A/HGS/SRC/ARFGAP1/SH3KBP1/GBF1/WASL/EHD1/CBLB/RAB31/BIN1/VPS4A/FOLR2/ARPC5L/RNF41/VPS37C/VPS4B/PIP5K1A/PRKCI/CAV2/IL2RB/AP2A2/RAB11A/VPS37B/EPN1/CLTB/ZFYVE27/GRK6/WIPF2/MVB12A/RAB11B/ACAP1/PSD4/VPS25/VPS26B/VPS28/CYTH2/EEA1/SH3GL1/AP2A1	2.75785838202744
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1157	34/9376	2.38344603182673	POLR2L/POLR2J/CRCP/POLR3GL/POLR2D/POLR2H/POLR3A/POLR1A/POLR3D/POLR2F	3.03196774267911
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	24/1157	116/9376	1.6766310016988	GAPDH/TPI1/HK1/DLST/CS/GOT2/PDHA1/SUCLG1/SDHA/ALDH6A1/PCCA/ACAT1/ECHS1/IDH3G/ACADS/G6PD/PFKP/OGDH/MDH2/TKT/PRPS2/PDHB/ME3/PFKL	2.75117502935967
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/1157	30/9376	2.43111495246327	DLST/CS/PDHA1/SUCLG1/SDHA/IDH3G/OGDH/MDH2/PDHB	2.94554109199752
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1157	105/9376	1.69792155410133	RPS27A/UBA52/RELA/TBC1D15/MFN2/SRC/FUNDC1/BECN1/MON1B/NBR1/GABARAP/HUWE1/CSNK2B/TOMM70/VCP/CSNK2A2/TOMM40/ATG9B/PHB2/TP53/OPTN/RHOT2	2.6982413744746
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/1157	93/9376	1.74273473294858	MYL9/EGFR/ACTG1/SRC/TJP1/WASL/NECTIN2/PTPRM/WAS/CSNK2B/CREBBP/CSNK2A2/HEG1/INSR/TCF7/TCF7L2/KRIT1/FYN/ARHGAP29/PTPRF	2.70068455078597
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1157	93/9376	1.74273473294858	FN1/RELA/LAMA4/PIK3CA/BAK1/COL4A2/ITGB1/IKBKG/COL4A1/PTK2/LAMB3/RXRB/DDB2/AKT2/CDK4/LAMA3/ITGA3/RXRA/TP53/TRAF5	2.70068455078597
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/1157	157/9376	1.54848086144157	MT-CYB/MT-CO2/MT-CO3/COX7A1/COX4I1/NDUFA5/MAPK14/RELA/PIK3CA/GSK3A/COX6C/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/MAP3K11/COX7A2L/SDHA/MLXIP/NDUFA2/INSR/BCL2L11/AKT2/MAP3K5/NDUFS3/RXRA/NDUFA13/NDUFA4L2/NDUFA8/NDUFB11	2.6002327514278
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	40/1157	224/9376	1.44709223360909	HLA-DRB5/IL1R1/HLA-E/IL1R2/HLA-G/HLA-DRA/RANBP3/CDC16/RELA/PIK3CA/ELK1/PPP3CA/CCND3/CREB1/HLA-DPB1/ANAPC13/NFATC3/MAP3K3/IL15/PPP3CB/KAT5/IKBKG/CREB3/CREBBP/CREB3L1/SLC2A1/CD3D/MAP2K2/IL2RB/AKT2/STAT5B/CDK4/SLC25A6/FDPS/CD3E/CD3G/ANAPC16/HLA-DOA/TP53/SRF	2.54100755755063
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/1157	42/9376	2.12240194262666	AOC1/DLST/MAOA/ALDH7A1/MAOB/HADH/ALDH9A1/ACAT1/ECHS1/KYAT3/GCDH	2.73515526088997
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	44/1157	253/9376	1.40934200142798	MYL9/RPS27A/UBA52/IL1R1/EGFR/PXN/FOXO1/MAPK14/ARPC1A/ACTG1/BTRC/HK1/RELA/UBE2V1/PIK3CA/SRC/NFKBIB/GSK3A/CAPN1/BECN1/RBCK1/UBE2V2/IRF3/WASL/TRADD/ITGB1/CRKL/ARPC5L/IKBKG/PTK2/WIPI2/CAPN2/SHARPIN/AKT2/CRK/PLCG2/ATG14/FBXW11/RRAGA/CYTH2/TP53/CAPNS1/ILK/TRAF5	2.47639865390262
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/1157	89/9376	1.73000689501131	FN1/COL6A3/ITGB8/ITGA1/COL6A2/LAMA4/TNXB/COL4A2/COL1A1/ITGB1/HSPG2/COL4A1/VWF/LAMB3/ITGB7/LAMA3/COL1A2/VTN/ITGA3	2.59613379198034
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	41/1157	233/9376	1.4259758662517	FN1/DCN/FBLN1/MYL9/TPM1/COL6A3/FBN1/TPM2/SPTBN1/PDLIM1/NID1/ITGB8/INF2/ITGA1/COL6A2/VCAN/ACTG1/SYNE2/DSP/PDLIM2/PDLIM4/NID2/BGN/FHL2/COL4A2/COL1A1/PDLIM7/ITGB1/COL5A1/LMOD1/HSPG2/COL4A1/DTNA/ITGB7/SUN1/FMNL1/SNTB2/COL1A2/DSG2/ITGA3/FHL1	2.47036669054997
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1157	48/9376	2.02592912705272	ACAA2/ALDH7A1/HADH/IVD/ALDH9A1/ALDH6A1/PCCA/ACAT1/ECHS1/ACADS/HSD17B10/ACAA1	2.67353908447639
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1157	60/9376	1.89086718524921	HSPB1/KDR/PXN/MAPK14/MAPKAPK2/PIK3CA/SRC/PPP3CA/PPP3CB/PRKCB/PTK2/MAP2K2/AKT2/PLCG2	2.59726746238087
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1157	109/9376	1.6356125062444	HLA-DRB5/IL1R1/HLA-DRA/MAPK14/EBI3/RELA/GATA3/NFKBIB/PPP3CA/HLA-DPB1/NFATC3/PPP3CB/RARA/IKBKG/RXRB/CD3D/IL2RB/STAT5B/CD3E/CD3G/RXRA/HLA-DOA	2.50425718600963
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/1157	109/9376	1.6356125062444	FOXO1/RELA/PIK3CA/GFPT1/NR1H2/PDPK1/CREB1/PRKCB/CREB3/OGA/CREB3L1/RPS6KA3/SLC2A1/MLXIP/PTPN11/SLC27A1/INSR/PTPA/AKT2/TRIB3/CPT1A/PTPRF	2.50425718600963
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/1157	78/9376	1.76619462358442	FN1/CAV1/PXN/ARPC1A/ACTG1/PIK3CA/SRC/WASL/ITGB1/CRKL/ARPC5L/PTK2/CAV2/CLTB/CRK/SHC1/ILK	2.54937931697342
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/1157	142/9376	1.54084750508235	RPS27A/UBA52/ELOB/CDC16/BTRC/CUL4B/UBE2S/ANAPC13/CBLB/PRPF19/HUWE1/KEAP1/WWP2/UBE2M/SAE1/TRIM37/UBE2O/HERC3/DDB2/UBE2L3/UBE2Q2/FBXW11/MGRN1/PIAS3/UBE2K/ANAPC16/DDB1	2.43650268998136
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/1157	142/9376	1.54084750508235	IL1R1/CAV1/GSTP1/IL1R2/KDR/MMP2/MAPK14/ACTG1/RELA/PIK3CA/MGST2/SRC/KEAP1/GSTA1/IKBKG/PTK2/CAV2/AKT2/BMP4/PDGFA/ASS1/MAP3K5/BMPR2/BMPR1A/SUMO3/TP53/PECAM1	2.43650268998136
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1157	73/9376	1.77615704289554	EGFR/PIK3CA/BAK1/ARAF/PDPK1/PRKCB/RASSF1/RXRB/DDB2/MAP2K2/AKT2/STAT5B/CDK4/PLCG2/RXRA/TP53	2.49771193855705
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1157	44/9376	2.02592912705272	GTF2A1/GTF2F1/TAF15/TAF5L/TAF3/ERCC3/TAF2/CDK7/TAF4/TAF10/GTF2E2	2.55917014478542
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1157	44/9376	2.02592912705272	DCTN5/CREB1/DYNLL2/CREB3/DYNC1LI2/CREB3L1/DYNC1LI1/RAB11A/DCTN2/RAB11B/DCTN1	2.55917014478542
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1157	137/9376	1.53793160009842	CSF2RB/ACTG1/RELA/PIK3CA/BAK1/TNFSF10/CAPN1/PDPK1/CTSK/TRADD/TUBA3E/IKBKG/CTSW/CAPN2/FADD/MAP2K2/BCL2L11/AKT2/MAP3K5/PARP2/NOL3/DFFA/PARP3/PTPN13/TP53/CASP6	2.37967519993305
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/1157	50/9376	1.94489196197061	AOC1/MAOA/ALDH7A1/GOT2/PYCR2/MAOB/ALDH9A1/ALDH4A1/SMOX/SRM/P4HA2/ALDH18A1	2.51340386508888
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1157	19/9376	2.55906837101397	DLST/PDHA1/LIAS/OGDH/PDHB/LIPT1	2.55221040117821
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/1157	90/9376	1.62074330164218	EGFR/MAPK14/RELA/PIK3CA/NFKBIB/PPP3CA/NFATC3/MAP3K3/PPP3CB/IKBKG/CSNK2B/CSNK2A2/PTPN11/CD3D/MAP2K2/AKT2/CD3E/CD3G	2.22004503433606
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1157	59/9376	1.78556465435155	EGFR/PIK3CA/BAK1/ARAF/ELK1/PDPK1/DDB2/MAP2K2/AKT2/TCF7/TCF7L2/TP53/ILK	2.27097691807536
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1157	37/9376	1.97117428578103	BAK1/CCDC6/RXRB/DDB2/MAP2K2/TCF7/TCF7L2/RXRA/TP53	2.22070400933156
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/1157	93/9376	1.56846125965372	HLA-DRB5/HLA-DRA/MAPK14/RELA/GATA3/NFKBIB/PPP3CA/HLA-DPB1/NOTCH1/NFATC3/PPP3CB/IKBKG/CD3D/IL2RB/STAT5B/CD3E/CD3G/HLA-DOA	2.06700248899417
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1157	32/9376	2.02592912705272	BECN1/ATG10/GABARAP/ATG13/ATG4A/WIPI2/ATG9B/IGBP1	2.1810657690559
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	29/1157	169/9376	1.39057857241489	RPS27A/UBA52/MTMR14/PIK3CA/VPS41/GORASP2/WDR45B/SNAP29/BECN1/PDPK1/NBR1/ATG10/GABARAP/ZFYVE1/VPS18/ATG13/ATG4A/WIPI2/WDR41/MAP2K2/TSC2/AKT2/ATG9B/ATG14/RRAGA/IGBP1/YKT6/HMGB1/OPTN	1.92236354423323
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/1157	362/9376	1.25361360348014	FN1/FLT1/PRL/RPS6/PRLR/F2R/COL6A3/EGFR/KDR/ITGB8/ITGA1/COL6A2/CSH1/RELA/LAMA4/PIK3CA/TNXB/COL4A2/PDPK1/CCND3/CREB1/COL1A1/EIF4E2/ITGB1/IKBKG/PPP2R5A/COL4A1/CREB3/CREB3L1/PTK2/VWF/LAMB3/GNB2/INSR/ITGB7/MAP2K2/TSC2/IL2RB/BCL2L11/AKT2/PPP2R5B/CDK4/LAMA3/PDGFA/YWHAE/COL1A2/EFNA1/GNG11/GNB1/VTN/OSMR/ITGA3/RXRA/GNG12/TP53/YWHAQ	1.84633660775689
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	34/1157	205/9376	1.3440310306301	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/MAPK14/RELA/PIK3CA/BAK1/NFKBIB/SNW1/CCND3/HLA-DPB1/IRF3/TRADD/HDAC2/IKBKG/PSMD3/DDB2/ADRM1/CD3D/FADD/BCL2L11/AKT2/CDK4/PSMC1/PLCG2/CD3E/HDAC1/PSMD1/CD3G/HLA-DOA/TP53/PSMC5/TRAF5	1.86856851902289
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1157	248/9376	1.30705104971143	MYL9/RPS3/GAPDH/MAPK14/AHNAK2/ARPC1A/DCTN5/ACTG1/RELA/PIK3CA/BAK1/VPS41/TNFSF10/CSE1L/WASL/TRADD/VPS18/TUBA3E/DYNLL2/ARPC5L/IKBKG/DYNC1LI2/DYNC1LI1/FLNA/FADD/MAP2K2/NCKAP1/AKT2/TCF7/BRK1/TCF7L2/FYCO1/DCTN2/GCC2/PODXL/DYNLRB1/ACTR1A/CYTH2/DCTN1/STX10	1.83861770817881
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/1157	227/9376	1.32087009164671	IL1R1/HLA-E/EGFR/HLA-G/PXN/MAPK14/RELA/PIK3CA/BAK1/SRC/ELK1/PPP3CA/CREB1/IRF3/ARHGEF1/GNA12/TRADD/NFATC3/PPP3CB/CRKL/PRKCB/IKBKG/CREB3/CREB3L1/PTK2/GNB2/FADD/MAP2K2/TSC2/AKT2/CDK4/CRK/GNG11/GNB1/GNG12/TP53/TRAF5	1.83610782127402
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/1157	214/9376	1.32537419526814	ELOB/HLA-E/HLA-G/PXN/MAPK14/BTRC/RELA/PIK3CA/BAK1/CUL4B/PPP3CA/IRF3/TRADD/NFATC3/PPP3CB/CRKL/PRKCB/IKBKG/PTK2/GNB2/CD3D/FADD/MAP2K2/AKT2/PAK4/CRK/PLCG2/FBXW11/CD3E/CD3G/GNG11/GNB1/DDB1/GNG12/TRAF5	1.80649879995898
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/1157	138/9376	1.40934200142798	FN1/PXN/MAPK14/ARPC1A/ACTG1/RELA/PIK3CA/SRC/IRF3/ARHGEF1/WASL/NFATC3/ITGB1/WAS/CRKL/ARPC5L/IKBKG/PTK2/RPS6KA3/PIP5K1A/MAP2K2/AKT2/CRK/WIPF2	1.8175221001334
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/1157	78/9376	1.55840702080979	CNOT7/CNOT6/EXOSC8/LSM3/TOB2/TENT4B/PARN/NUDT16/DHX36/PFKP/DIS3L/EXOSC7/DCP1B/PFKL/CNOT6L	1.8580022170416
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	32/1157	196/9376	1.32305575644259	RPS27A/UBA52/HLA-E/HLA-G/MAPK14/MAPKAPK2/RELA/PIK3CA/BAK1/SRC/BECN1/PPP3CA/CREB1/IRF3/TRADD/NFATC3/PPP3CB/IKBKG/CREBBP/GNB2/FADD/MAP2K2/AKT2/TCF7/TCF7L2/CDK4/PLCG2/ATG14/GNG11/GNB1/GNG12/TP53	1.71485343042813
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1157	35/9376	1.85227805901963	TPI1/HK1/GMPPA/HSD17B14/GMPPB/PFKP/MPI/PFKL	1.89522803370751
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1157	86/9376	1.50766818757412	EGFR/PIK3CA/SRC/ARAF/ELK1/CBLB/CRKL/PRKCB/PTK2/MAP2K2/AKT2/PAK4/STAT5B/CRK/PLCG2/SHC1	1.77445155003077
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/1157	205/9376	1.3045007061998	HLA-E/HLA-G/PXN/GTF2A1/MAPKAPK2/RELA/PIK3CA/BAK1/SRC/SNW1/CCND3/CREB1/IRF3/TRADD/HDAC2/HDAC3/HDAC6/IKBKG/CREB3/CREBBP/CREB3L1/GTF2E2/STAT5B/CDK4/PSMC1/YWHAE/ATP6V0D1/HDAC1/DDB1/TP53/TRAF5/SRF/YWHAQ	1.65386370114083
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1157	122/9376	1.39490202190515	MAPK14/RELA/PIK3CA/NFKBIB/PPP3CA/PDPK1/NFATC3/CBLB/PPP3CB/IKBKG/PPP2R5A/PTPN11/CD3D/MAP2K2/AKT2/PAK4/PPP2R5B/CDK4/CD3E/CD3G/FYN	1.64720386463948
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/1157	243/9376	1.26724784902063	CRNKL1/PLRG1/BUD31/RBMX2/PRPF31/CTNNBL1/DDX42/SNW1/SNIP1/DHX38/CASC3/PRPF4/SNRPE/SF3B3/U2SURP/SF3B4/SF3A1/LSM3/PRPF19/SNRPD1/RBMX/SLU7/SNRPB/XAB2/SNRPC/GPKOW/SF3B2/SART1/SNRPA/ISY1/PRPF40A/SNRPG/ZMAT2/SNRPD3/THOC2/SF3B5/SF3A2/YJU2	1.58362902819363
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1157	49/9376	1.65381969555324	GALNT15/GALNT7/GALNT11/POGLUT1/GALNT2/MFNG/EOGT/PLOD3/FUT11/POFUT2	1.72158265365893
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/1157	43/9376	1.69612671102088	APOA1/PLPP1/SCARB1/AGPAT2/GOT2/ACAT1/SLC27A1/AGPAT1/PLPP3	1.71654313264538
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/1157	174/9376	1.30404633465463	CRYAB/SSR4/SEC13/MAGT1/BCAP29/PLAA/BAK1/SEC62/DDOST/CAPN1/SAR1A/MAN1B1/SSR1/VCP/BAG1/RNF185/UBXN2A/CAPN2/SEC31A/UBXN4/DNAJC5/STT3A/MAP3K5/TUSC3/UBQLN4/GANAB/SEC61A1/UBXN1	1.51885428022837
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1157	70/9376	1.50497592295345	ELOB/PIK3CA/EGLN1/ARAF/CRKL/CREBBP/SLC2A1/PTPN11/MAP2K2/AKT2/PAK4/EPAS1/CRK	1.5910396215567
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1157	44/9376	1.6575783766795	MAGT1/DDOST/MAN1B1/MGAT4B/MAN2A1/STT3A/ALG3/TUSC3/MAN2A2	1.64032281088376
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1157	184/9376	1.27721618879411	MYL9/SEMA3B/WNT4/PIK3CA/SRC/WNT5A/PPP3CA/PDPK1/SEMA5A/NFATC3/ITGB1/EPHB2/PPP3CB/ABLIM1/RASA1/PTK2/PTPN11/PAK4/RHOD/PLCG2/DPYSL2/SEMA3A/EFNA1/FYN/PLXNB2/BMPR2/EFNB1/ILK/PLXNA3	1.42483744388017
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1157	65/9376	1.4960707399774	PLPP1/AGPAT2/ALDH7A1/PLPP5/DGKZ/ALDH9A1/GPAT4/AGPAT1/LPIN1/AGPAT5/PLPP3/AGPAT4	1.50572254816809
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/1157	120/9376	1.35061941803515	MAPK14/MAPKAPK2/RELA/PIK3CA/NFKBIB/PDPK1/MAP3K3/PRDM4/FRS2/CRKL/RPS6KA3/PTPN11/MAP2K2/AKT2/CRK/YWHAE/PLCG2/MAP3K5/SHC1/TP53	1.45029964966243
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/1157	250/9376	1.23176490924806	CD63/CLN5/ACP5/KXD1/VPS41/WDR7/SNAP29/AP3D1/GUSB/CTSK/GLB1/VPS18/BLOC1S4/NAGLU/TTI1/CTSW/GGA3/OSBPL1A/AP5Z1/SUMF1/SLC29A1/AP2A2/ARSA/CLTB/CLN6/ATP6V1E1/LAMTOR1/ATP6V0D1/TPCN1/AP3M2/FUCA2/RRAGA/VPS26B/GAA/NCOA7/TPCN2/TLR7/AP2A1	1.39354270154786
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1157	15/9376	2.16099106885624	GLB1/ST6GALNAC4/ST3GAL2/ST3GAL5	1.68832562919969
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1157	33/9376	1.71897016840837	DLST/CS/GOT2/PDHA1/IDH3G/OGDH/PDHB	1.55227082124852
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1157	33/9376	1.71897016840837	STX8/SNAP29/STX16/VAMP4/VTI1B/YKT6/BET1L	1.55227082124852
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/1157	157/9376	1.29040071786798	IGFBP3/SERPINE1/HLA-E/HLA-G/FOXO1/MAPK14/MAPKAPK2/BTRC/RELA/PIK3CA/CAPN1/PPP3CA/CCND3/NFATC3/PPP3CB/CAPN2/MAP2K2/TSC2/HIPK2/AKT2/TRAF3IP2/CDK4/SLC25A6/FBXW11/TP53	1.37672890837759
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/1157	136/9376	1.3108953175047	RACK1/RELA/PIK3CA/BAK1/NFKBIB/CCND3/IRF3/TRADD/CBLB/IKBKG/CSNK2B/CSNK2A2/CD3D/FADD/IL2RB/AKT2/STAT5B/CDK4/CD3E/CD3G/TP53/TLR7	1.37022055147806
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1157	80/9376	1.41815038893691	RPS6/EGFR/KDR/PIK3CA/SRC/ARAF/EIF4E2/PRKCB/MAP2K2/BCL2L11/AKT2/PDGFA/PLCG2/SHC1	1.40919881236943
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	25/1157	158/9376	1.28223362471691	CDKN1C/CDC16/TFDP1/CCND3/ANAPC13/ORC3/PDS5B/HDAC2/PPP2R5A/CREBBP/CDK7/SMC3/ORC2/MCM5/PPP2R5B/CDK4/MAU2/TFDP2/YWHAE/ORC5/HDAC1/CDKN2D/ANAPC16/TP53/YWHAQ	1.34233765301224
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/1157	144/9376	1.29434360895035	PIK3CA/PSMA7/BECN1/AFG3L2/PRKCB/KAT5/ATG13/PSMD3/WIPI2/PSMB3/PSMB7/ADRM1/PSMB4/NOP56/PSMB5/AKT2/SLC25A6/PSMC1/ATG14/MAP3K5/CIC/PSMD1/PSMC5	1.33545969739299
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1157	130/9376	1.30906189748022	EGFR/MMP2/MAPK14/RELA/RXFP1/PIK3CA/SRC/COL4A2/CREB1/COL1A1/COL4A1/CREB3/CREB3L1/GNB2/MAP2K2/AKT2/SHC1/COL1A2/GNG11/GNB1/GNG12	1.33132174531891
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1157	88/9376	1.38131531389958	SERPINE2/CLU/SERPINE1/F2R/CD59/C1R/TFPI/CFD/SERPING1/SERPINB2/FGG/F10/VWF/A2M/VTN	1.34836449241325
NA	NA	hsa04517	IgSF CAM signaling	44/1157	299/9376	1.19252015505445	MYL9/MYL6/SPTBN1/KDR/PXN/FOXO1/MAPK14/ARPC1A/CLMP/ACTG1/PIK3CA/SRC/PDPK1/TJP1/WASL/NECTIN2/ITGB1/PRKCB/TUBA3E/DYNLL2/EPB41L2/ARPC5L/FGG/RASA1/PTK2/PTPN11/JAM2/PRKCI/PPFIA1/MAP2K2/AKT2/DOK2/PAK4/KCNQ3/PLCG2/CSK/FYN/JAML/MYL6B/CADM1/NLGN4X/PLXNA3/PTPRF/CD2	1.26935604820494
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1157	41/9376	1.58121297721188	EGFR/MMP2/SRC/ARAF/RASSF1/MAP2K2/CDK4/TP53	1.39930664738774
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1157	16/9376	2.02592912705272	MIF/MAOA/GOT2/MAOB	1.54092767240295
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1157	22/9376	1.84175375186611	AOC1/MAOA/ALDH7A1/MAOB/ALDH9A1	1.48299793357864
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	25/1157	160/9376	1.26620570440795	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/ITGB8/VCAN/CLDN5/HLA-DPB1/NECTIN2/PTPRM/ITGB1/JAM2/ITGB7/CLDN19/SELPLG/ICOSLG/JAML/GLG1/CD34/HLA-DOA/CADM1/NLGN4X/PECAM1/PTPRF/CD2	1.27423327893338
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/1157	103/9376	1.33750660815131	NUDT21/GSPT1/SSU72/CPSF2/CASC3/GLE1/WDR82/CSTF1/SMG6/FIP1L1/PPP2R5A/UPF1/CSTF3/CPSF1/PPP2R5B/HBS1L/UPF3A	1.29221146620799
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1157	48/9376	1.51944684528954	CD81/CD63/EGFR/CLDN5/SCARB1/VPS4A/HSPG2/VPS4B/CLDN19	1.35366216492865
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/1157	76/9376	1.38616203429923	EGFR/PIK3CA/BAK1/ARAF/PRKCB/DDB2/MAP2K2/AKT2/CDK4/PDGFA/PLCG2/SHC1/TP53	1.26817072344436
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/1157	200/9376	1.21555747623163	F2R/RPS3/IL1R1/GAPDH/MAPK14/ARPC1A/ACTG1/CLDN5/RELA/BAK1/SRC/NFKBIB/TNFSF10/ARHGEF1/TJP1/GNA12/WASL/TRADD/ITGB1/TUBA3E/ARPC5L/IKBKG/PTPN11/FADD/NCKAP1/BRK1/CLDN19/WIPF2/FYN/CYTH2	1.15609683710482
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	23/1157	149/9376	1.25090925965671	F2R/EGFR/GAB2/PLPP1/PIK3CA/AGPAT2/GNA12/DGKZ/PIP5K1A/PTPN11/INSR/MAP2K2/TSC2/AKT2/AGPAT1/AGPAT5/PDGFA/PLCG2/SHC1/FYN/PLPP3/CYTH2/AGPAT4	1.15830355789131
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	23/1157	149/9376	1.25090925965671	MT-ND3/NDUFA5/MAPK14/MT-ND4/NDUFS4/NDUFB6/NDUFA10/NDUFAB1/PRKCB/CNR1/MT-ND1/GNB2/NDUFA2/NAPEPLD/NDUFS3/GNG11/GNB1/GNG12/NDUFA13/NDUFA4L2/ABHD6/NDUFA8/NDUFB11	1.15830355789131
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1157	157/9376	1.23878468915326	MFGE8/MAPK14/BSG/MAPKAPK2/RAB14/VPS41/NR1H2/CREB1/NFATC3/VPS18/DUSP16/CRKL/PTK2/SLC2A1/PTPN11/MAP2K2/ATP8A2/CD24/CRK/ATP11C/RXRA/CPT1A/PECAM1/PBX1	1.13202813976755
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/1157	157/9376	1.23878468915326	SERPINE1/WNT4/ACTG1/BTRC/WNT5A/CCND3/TEAD1/WWTR1/LATS2/DVL2/RASSF1/PRKCI/BMP8B/TCF7/BMP4/TCF7L2/YWHAE/FBXW11/NKD2/BMPR2/BMPR1A/WNT10B/DLG5/YWHAQ	1.13202813976755
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1157	99/9376	1.30969155688257	EGFR/PLPP1/PIK3CA/PDPK1/SLC44A2/WAS/PRKCB/LYPLA1/PCYT1A/DGKZ/PIP5K1A/MAP2K2/TSC2/AKT2/PDGFA/PLPP3	1.16221375693076
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1157	30/9376	1.62074330164218	PIGP/PIGS/PIGM/PGAP2/DPM2/PIGO	1.27762266715341
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1157	57/9376	1.42170465056331	ACAA2/CPT2/HADH/FADS1/ACAT1/ECHS1/ACADS/CPT1A/ELOVL1/ACAA1	1.19813013037056
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1157	71/9376	1.36964222673987	EGFR/MAPK14/RELA/SRC/TJP1/IKBKG/PTPN11/JAM2/ATP6V1E1/PLCG2/ATP6V0D1/CSK	1.17299292020359
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1157	71/9376	1.36964222673987	EGFR/HK1/PIK3CA/PDHA1/SLC2A1/MAP2K2/AKT2/G6PD/PFKP/PDHB/TP53/PFKL	1.17299292020359
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/1157	232/9376	1.18761362620332	FN1/MYL9/F2R/RGCC/EGFR/ITGB8/PXN/ITGA1/ARPC1A/ACTG1/PIK3CA/SRC/ARAF/ARHGEF1/GNA12/WASL/ITGB1/CRKL/ARPC5L/PTK2/PIP5K1A/ITGB7/MAP2K2/NCKAP1/TIAM1/AKT2/PAK4/BRK1/PDGFA/CRK/ITGA3/GNG12/PIP4K2B/PPP1R12C	1.08563313171213
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/1157	100/9376	1.29659464131374	HLA-DRB5/CD59/IL1R1/IL1R2/HLA-DRA/ITGA1/CSF2RA/HLA-DPB1/CD3D/CD24/CD3E/CD3G/CD34/ITGA3/HLA-DOA/CD2	1.1187312193125
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1157	108/9376	1.27558500592208	EEF1A1/SEC13/CSE1L/CASC3/GLE1/UPF1/PHAX/KPNB1/SNUPN/IPO5/NUP37/IPO9/RANGAP1/UPF3A/IPO13/THOC2/SUMO3	1.08073017449555
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1157	31/9376	1.56846125965372	ALDH7A1/ALDH9A1/ALDH6A1/ECHS1/ACADS/SMOX	1.18941906265161
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/1157	101/9376	1.28375707060767	FN1/SERPINE1/MMP2/FOXO1/MAPK14/RELA/PIK3CA/COL4A2/COL1A1/PRKCB/COL4A1/AKT2/STAT5B/CDK4/PLCG2/COL1A2	1.07570514843409
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1157	73/9376	1.33211778217165	MAP1B/HGS/SMARCB1/MAP1A/VPS4A/FURIN/CREBBP/SUPT4H1/VPS4B/NELFB/BICD2/SUPT5H	1.06877152907427
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1157	59/9376	1.37351127257812	GSTP1/GPX4/MGST2/GSTA1/GCLC/GPX8/G6PD/SRM/GPX3/LANCL1	1.07977806023622
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/1157	125/9376	1.23176490924806	GAB2/MAPK14/CERS6/RELA/SPTLC2/PIK3CA/CERS5/PDPK1/GNA12/TRADD/PRKCB/PPP2R5A/MAP2K2/AKT2/PPP2R5B/MAP3K5/FYN/TP53/ORMDL3	0.978703575664685
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/1157	238/9376	1.15767378688727	FLT1/EGFR/RASGRP2/KDR/GAB2/BRAP/RELA/PIK3CA/ELK1/RGL2/RASA3/PRKCB/IKBKG/RASA1/RASAL3/PTPN11/GNB2/INSR/RASSF1/MAP2K2/TIAM1/AKT2/PAK4/RASA4/PDGFA/KSR1/PLCG2/SHC1/EFNA1/SYNGAP1/GNG11/GNB1/GNG12/RASGRP4	0.924411261184716
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1157	178/9376	1.18368892816564	NOTUM/DKK1/WNT4/BTRC/WNT5A/APCDD1/CTBP2/SFRP1/PPP3CA/CCND3/NFATC3/PPP3CB/PRKCB/CSNK2B/CREBBP/CSNK2A2/DVL2/LGR4/TCF7/TCF7L2/FBXW11/NKD2/SERPINF1/WNT10B/TP53/VANGL1	0.928301615016496
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1157	75/9376	1.29659464131374	GAPDH/TPI1/CS/GOT2/PYCR2/IDH3G/ASS1/PFKP/TKT/PRPS2/ALDH18A1/PFKL	0.967546702524476
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/1157	75/9376	1.29659464131374	IGFBP3/SERPINE1/CD82/EI24/CCND3/PERP/CCNG2/DDB2/TSC2/AIFM2/CDK4/TP53	0.967546702524476
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1157	47/9376	1.3793560013976	GLO1/ALDH7A1/PDHA1/ALDH9A1/ACAT1/MDH2/PDHB/ME3	0.978185382947406
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1157	83/9376	1.26925680249086	POLR2L/RELA/NFKBIB/POLR3GL/IRF3/ZCCHC3/POLR2H/IKBKG/DDX41/FADD/POLR3A/POLR3D/POLR2F	0.924422673932309
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1157	105/9376	1.23485203934642	MAPK14/MAPKAPK2/RELA/PIK3CA/SRC/BCL3/PPP3CA/NFATC3/CBLB/PPP3CB/IKBKG/PTPN11/AKT2/KSR1/PLCG2/LSP1	0.907963775757308
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1157	173/9376	1.17105729887441	HLA-DRB5/HLA-DRA/ACTG1/RELA/PIK3CA/BAK1/NFKBIB/TNFSF10/CCND3/HLA-DPB1/IRF3/TRADD/PRKCB/IKBKG/CREBBP/FADD/MAP2K2/AKT2/RAB11A/CDK4/SLC25A6/FDPS/RAB11B/HLA-DOA/TLR7	0.85200624471806
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1157	20/9376	1.62074330164218	GMPPA/CYB5R1/CMAS/GMPPB	1.0426169008011
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1157	41/9376	1.3835613550604	BABAM1/RPA2/SSBP1/MUS81/BRCC3/RBBP8/RPA3	0.923447986987048
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1157	70/9376	1.273441165576	RELA/NFKBIB/TRADD/IKBKG/SLC2A1/PTPN11/RXRB/AKT2/POMC/RXRA/CPT1A	0.86153756807166
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1157	70/9376	1.273441165576	HLA-DRB5/CAV1/HLA-E/HLA-G/HLA-DRA/ACTG1/HLA-DPB1/DTNA/SNTB2/FYN/HLA-DOA	0.86153756807166
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1157	63/9376	1.28630420765252	WNT4/BAK1/WNT5A/DVL2/DDB2/TCF7/BMP4/TCF7L2/WNT10B/TP53	0.855452759051347
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/1157	85/9376	1.2393919365499	AK3/HDDC2/GUK1/AK2/DGUOK/CANT1/NME6/ENTPD6/ADK/NUDT16/UCK2/UCK1/ENPP1	0.83182233679223
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1157	138/9376	1.17445166785665	RPS6/FOXO1/HK1/PIK3CA/ARAF/ELK1/PDPK1/FLOT2/EIF4E2/CBLB/CRKL/INSR/PRKCI/MAP2K2/TSC2/AKT2/CRK/SHC1/PHKG2/PTPRF	0.774583992428098
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1157	86/9376	1.22498040240397	GJA1/ITGB8/ITGA1/ACTG1/DSP/ITGB1/DTNA/ITGB7/TCF7/TCF7L2/SNTB2/DSG2/ITGA3	0.786373528110795
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/1157	116/9376	1.18761362620332	MYL9/THY1/MMP2/PXN/MAPK14/ACTG1/CLDN5/PIK3CA/ARHGAP5/ITGB1/PRKCB/PTK2/PTPN11/JAM2/PLCG2/CLDN19/PECAM1	0.762835167591029
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	41/1157	300/9376	1.10750792278882	FLT1/HSPB1/IL1R1/EGFR/RASGRP2/KDR/MAPK14/MAPKAPK2/RELA/ARAF/ELK1/PPP3CA/GNA12/TRADD/NFATC3/MAP3K3/PPP3CB/DUSP16/CRKL/PRKCB/IKBKG/MAP3K11/MAP3K4/MAP4K4/RASA1/TAOK1/FLNA/RPS6KA3/INSR/MAP2K2/AKT2/PDGFA/CRK/MAP3K6/MAP3K5/EFNA1/TAOK2/GNG12/TP53/RASGRP4/SRF	0.710062671269308
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/1157	155/9376	1.15020492374606	EGFR/WNT4/CYP11A1/KCNK3/SCARB1/WNT5A/ASH2L/CREB1/HSD3B1/CREB3/CREB3L1/DVL2/MAP2K2/TCF7/TCF7L2/CDK4/ARMC5/POMC/STAR/WNT10B/PBX1/WDR5	0.70746316827717
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/1157	163/9376	1.14346920054509	MAPK14/RELA/PIK3CA/SRC/ARAF/ELK1/CREB1/IRF3/NFATC3/PRKCB/HSPG2/IKBKG/CREB3/CREBBP/CREB3L1/DDB2/FADD/MAP2K2/AKT2/STAT5B/DDB1/TP53/YWHAQ	0.69325781235483
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1157	65/9376	1.24672561664783	CYP11A1/KCNK3/SCARB1/CREB1/HSD3B1/CREB3/CREB3L1/POMC/STAR/PBX1	0.748885782326612
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1157	15/9376	1.62074330164218	AK2/NFS1/THTPA	0.902691548134807
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1157	36/9376	1.35061941803515	GALNT15/GALNT7/GALNT11/GALNT2/ST6GALNAC4/ST3GAL2	0.790781688739739
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1157	36/9376	1.35061941803515	RFC2/POLE3/RPA2/SSBP1/MCM5/RPA3	0.790781688739739
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1157	29/9376	1.39719250141567	RASSF2/TEAD1/WWTR1/LATS2/RASSF1	0.803723646412934
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1157	103/9376	1.18015288954528	FN1/HSPB1/IL1R1/IL1R2/RELA/LAMA4/PIK3CA/COL4A2/COL1A1/PRKCB/COL4A1/PTK2/LAMB3/LAMA3/COL1A2	0.689751323140136
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1157	44/9376	1.28922762630628	APTX/RFC2/APEX1/POLE3/PARP2/PARP3/HMGB1	0.721475476982089
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1157	59/9376	1.23616014532031	HDDC2/CANT1/NME6/ENTPD6/UMPS/NUDT2/UCK2/UCK1/ENPP1	0.682711774289845
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1157	37/9376	1.31411619052069	HK1/GMPPA/GFPT1/CMAS/GMPPB/MPI	0.718263543318859
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1157	67/9376	1.20950992659864	GAPDH/TPI1/HK1/ALDH7A1/PDHA1/BPGM/ALDH9A1/PFKP/PDHB/PFKL	0.645703764454118
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1157	23/9376	1.40934200142798	RFC2/RPA2/SSBP1/RPA3	0.737424541693092
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1157	90/9376	1.1705368289638	FOXO1/RELA/PIK3CA/CREB1/EHMT2/EIF4E2/ATG13/CREB3/CREB3L1/INSR/TSC2/AKT2/TP53	0.609913049904696
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1157	75/9376	1.18854508787093	GSTP1/PIK3CA/BAK1/MGST2/PDPK1/GSTA1/FADD/AKT2/MAP3K5/TP53/XPA	0.615069029024477
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/1157	98/9376	1.15767378688727	GAB2/ARPC1A/PLPP1/PIK3CA/BIN1/WAS/CRKL/PRKCB/ARPC5L/PIP5K1A/AKT2/CRK/PLCG2/PLPP3	0.58869206164172
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1157	38/9376	1.27953418550698	HK1/GMPPA/GFPT1/GMPPB/AMDHD2/MPI	0.647802497872753
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/1157	68/9376	1.19172301591337	RELA/PIK3CA/ARAF/RARA/IKBKG/MAP2K2/AKT2/TCF7/STAT5B/TCF7L2	0.595310233979629
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/1157	91/9376	1.15767378688727	CD81/RELA/PIK3CA/NFKBIB/PPP3CA/NFATC3/PPP3CB/PRKCB/IKBKG/MAP2K2/AKT2/LILRA6/PLCG2	0.567063988054903
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1157	122/9376	1.12920639868512	EEF2/FOXO1/PIK3CA/RAB14/PDPK1/CREB1/PPP2R5A/CREB3/CREB3L1/INSR/TSC2/AKT2/PPP2R5B/PFKP/RAB11B/CPT1A/PFKL	0.538941984200332
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/1157	122/9376	1.12920639868512	IGFBP3/MAPK14/CSH1/PIK3CA/CREB1/CRKL/PRKCB/CREB3/CREBBP/CREB3L1/PTK2/MAP2K2/AKT2/STAT5B/CRK/PLCG2/SHC1	0.538941984200332
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1157	31/9376	1.30705104971143	G6PD/PFKP/TKT/PRPS2/PFKL	0.642457802588757
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1157	99/9376	1.14598011227225	EGFR/MMP2/MAPK14/PIK3CA/SRC/CARM1/ARAF/NOTCH1/PTK2/MAP2K2/AKT2/CDK4/SHC1/TP53	0.547835712503574
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1157	107/9376	1.13603502451555	FOXO1/PPP3CA/CREB1/PDHA1/PPP3CB/CREB3/CREBBP/CREB3L1/SLC2A1/AKT2/PFKP/PDHB/CPT1A/PHKG2/PFKL	0.53096881463563
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1157	69/9376	1.17445166785665	MAOA/PPP3CA/CREB1/PPP3CB/PRKCB/HDAC2/MAOB/CREB3/CREB3L1/HDAC1	0.545679504001933
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	21/1157	154/9376	1.10505225111967	GMPPA/AK3/MTHFD1/AK2/GUSB/PPCS/NME6/ALAD/UMPS/DHRS3/NMNAT1/QPRT/LIAS/GCLC/FECH/GMPPB/NFS1/COQ6/MPI/LIPT1/UROS	0.493169252684228
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/1157	39/9376	1.24672561664783	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/HLA-DPB1/HLA-DOA	0.579276212142004
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1157	62/9376	1.17634594474029	SNW1/CTBP2/NOTCH1/HDAC2/CREBBP/MFNG/DVL2/APH1B/HDAC1	0.522680180571006
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1157	32/9376	1.26620570440795	HK1/GLB1/PFKP/GAA/PFKL	0.565937874363284
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1157	32/9376	1.26620570440795	SUCLG1/ALDH6A1/PCCA/ECHS1/ACADS	0.565937874363284
Human Diseases	Immune disease	hsa05310	Asthma	5/1157	32/9376	1.26620570440795	HLA-DRB5/PRG2/HLA-DRA/HLA-DPB1/HLA-DOA	0.565937874363284
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/1157	78/9376	1.14283181526051	TPI1/MTMR14/MTMR2/PIK3CA/INPP1/PIP5K1A/ALDH6A1/ITPK1/PLCG2/PIP4K2B/INPP5F	0.475248017177962
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/1157	78/9376	1.14283181526051	HLA-DRB5/EEF1A1/HLA-DRA/MAPK14/RELA/NFKBIB/ELK1/HLA-DPB1/ITGB1/PRKCB/HLA-DOA	0.475248017177962
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1157	55/9376	1.17872240119431	CERS6/SPTLC2/PLPP1/CERS5/GLB1/SMPD4/ARSA/PLPP3	0.49873736785185
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/1157	156/9376	1.09088491456685	CD81/EGFR/PSME3/CLDN5/RELA/PIK3CA/BAK1/SCARB1/ARAF/IRF3/TRADD/IKBKG/FADD/MAP2K2/AKT2/CDK4/YWHAE/CLDN19/RXRA/TP53/YWHAQ	0.429468652333273
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/1157	180/9376	1.08049553442812	HLA-DRB5/CD74/HLA-E/HLA-G/HLA-DRA/RELA/PIK3CA/BAK1/SRC/EIF2B5/HLA-DPB1/IRF3/POU2F1/NECTIN2/TRADD/IKBKG/PTPN11/FADD/TSC2/HCFC2/AKT2/HLA-DOA/TP53/TRAF5	0.409120636937249
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/1157	133/9376	1.09674358757741	EGFR/FOXO1/MAPK14/PIK3CA/DEPP1/TNFSF10/ARAF/PDPK1/GABARAP/SETD7/CREBBP/CCNG2/INSR/MAP2K2/BCL2L11/AKT2/FBXO25/CDKN2D	0.421584232723401
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1157	71/9376	1.14136852228322	PRL/PRLR/MAPK14/RELA/PIK3CA/SRC/MAP2K2/AKT2/STAT5B/SHC1	0.448607501476182
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1157	126/9376	1.09335857650464	F2R/RASGRP2/MAPK14/ACTG1/PIK3CA/SRC/STIM1/COL1A1/ARHGEF1/ITGB1/FGG/VWF/PRKCI/AKT2/PLCG2/COL1A2/FYN	0.395832505015823
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1157	18/9376	1.35061941803515	GLB1/MAN2B2/FUCA2	0.55862906011866
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/1157	158/9376	1.07707624476221	RPS6/WNT4/SEC13/PIK3CA/WNT5A/PDPK1/EIF4E2/PRKCB/TTI1/RPS6KA3/WDR59/DVL2/INSR/MAP2K2/TSC2/AKT2/LPIN1/ATP6V1E1/LAMTOR1/RRAGA/WNT10B	0.366584051070716
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1157	26/9376	1.24672561664783	APOA1/SCARB1/TCN2/SLC46A1	0.472648124683264
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1157	104/9376	1.09088491456685	PLPP1/AGPAT2/PLPP5/LYPLA1/PCYT1A/DGKZ/GPAT4/PISD/AGPAT1/LPIN1/AGPAT5/PEMT/PLPP3/AGPAT4	0.349675004331876
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1157	34/9376	1.19172301591337	RORB/BTRC/CREB1/FBXW11/CRY2	0.42018118987332
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1157	73/9376	1.11009815180971	EGFR/PIK3CA/BAK1/ARAF/DDB2/MAP2K2/AKT2/CDK4/PDGFA/TP53	0.354301324332881
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1157	19/9376	1.27953418550698	GUSB/GLB1/NAGLU	0.45760023678231
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1157	50/9376	1.13452031114952	HLA-DRB5/HLA-DRA/HLA-DPB1/IL15/ITGB7/ICOSLG/HLA-DOA	0.357822781422591
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/1157	193/9376	1.04970421090815	CXCL14/RASGRP2/PXN/RELA/CCL21/PIK3CA/SRC/NFKBIB/GSK3A/WAS/CRKL/PRKCB/IKBKG/PTK2/GNB2/TIAM1/AKT2/STAT5B/CRK/PLCG2/SHC1/GRK6/GNG11/GNB1/GNG12	0.2617715070154
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/1157	201/9376	1.04824193638549	IGFBP3/FLT1/HPGD/IL1R2/ZEB1/BMI1/FOXO1/RELA/SS18/BAK1/TAF15/FLI1/SPINT1/WT1/HDAC2/RARA/PTK2/RXRB/DDB2/ITGB7/IL2RB/PDGFA/HDAC1/RXRA/TP53/PBX1	0.259395567904056
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1157	27/9376	1.20055059380902	HADH/ACAT1/ECHS1/ACADS	0.391530935313491
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1157	51/9376	1.11227481485248	ACTG1/KDELR2/TJP1/ATP6V1E1/PLCG2/ATP6V0D1/SEC61A1	0.301637854331356
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1157	28/9376	1.15767378688727	ACAA2/HADH/ECHS1/ELOVL1	0.313488771224501
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1157	44/9376	1.10505225111967	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/HLA-DPB1/HLA-DOA	0.262051810031256
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1157	76/9376	1.06627848792249	APOA1/PDPK1/CPT2/SLC27A1/RXRB/RXRA/ME3/CPT1A/ILK/ACAA1	0.217661060673628
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/1157	133/9376	1.03581338826756	MAPK14/MAOA/GSK3A/PPP3CA/CREB1/PPP3CB/PRKCB/PPP2R5A/MAOB/CREB3/CREB3L1/GNB2/AKT2/PPP2R5B/GNG11/GNB1/GNG12	0.156065742361702
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1157	101/9376	1.04305261986873	WNT4/WNT5A/CREB1/PRKCB/CREB3/CREBBP/CREB3L1/DVL2/MAP2K2/TCF7/TCF7L2/POMC/WNT10B	0.163209765124759
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/1157	77/9376	1.05243071535206	EGFR/RELA/PIK3CA/BAK1/ARAF/IKBKG/DDB2/AKT2/CDK4/TP53	0.173322861050619
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1157	45/9376	1.08049553442812	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/HLA-DPB1/HLA-DOA	0.203075147679491
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1157	37/9376	1.0950968254339	HBB/APOA1/LAMA4/HBA2/PRKCB	0.217450054647957
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1157	21/9376	1.15767378688727	CHPF/B3GAT3/CHPF2	0.271387648002527
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/1157	142/9376	1.0272316700549	IL1R1/GAB2/MAPK14/RELA/TNFRSF11B/ACP5/PIK3CA/FHL2/PPP3CA/CREB1/CTSK/PPP3CB/IKBKG/AKT2/LILRA6/PLCG2/FYN/TYROBP	0.122677902214506
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/1157	110/9376	1.03138210104502	DCN/FBN1/EMP3/LTBP1/TFDP1/HDAC2/CREBBP/BMP8B/ID4/BMP4/HDAC1/BMPR2/NOG/BMPR1A	0.124215284535631
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1157	54/9376	1.05048176958289	MTAP/GOT2/GCLC/MDH2/ADI1/KYAT3/SRM	0.139578886144299
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/1157	119/9376	1.02147687078289	MAPK14/RELA/PIK3CA/BCL3/CREB1/TRADD/FRMD8/IL15/IKBKG/CREB3/CREB3L1/FADD/AKT2/MAP3K5/TRAF5	0.0884610684310452
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1157	38/9376	1.06627848792249	NNMT/SIRT5/NMNAT1/QPRT/ENPP1	0.15359613334428
NA	NA	hsa04382	Cornified envelope formation	27/1157	217/9376	1.00829652406311	S100A6/KRT18/KRT8/KRT7/KRT19/S100A4/S100A13/COL17A1/CLDN5/SPTLC2/DSP/CAPN1/COL4A2/TJP1/S100A16/PRSS8/FURIN/PPP2R5A/COL4A1/LAMB3/SLC27A1/PPP2R5B/KRT14/LAMA3/CLDN19/DSG2/ELOVL1	0.0463921865400767
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/1157	87/9376	1.02460783437149	EGFR/PIK3CA/BAK1/ARAF/DDB2/MAP2K2/BCL2L11/AKT2/TCF7/TCF7L2/TP53	0.0865149910794433
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1157	30/9376	1.08049553442812	RELA/FOLR2/IKBKG/SLC46A1	0.165677050590672
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1157	112/9376	1.01296456352636	HLA-DRB5/HLA-DRA/MAPK14/RELA/LAMA4/NFKBIB/PDPK1/HLA-DPB1/ITGB1/IKBKG/LAMB3/AKT2/LAMA3/HLA-DOA	0.0517857732869886
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1157	14/9376	1.15767378688727	ST3GAL2/CHST2	0.221504230491052
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1157	31/9376	1.04564083976915	GUSB/ALDH7A1/HSD17B14/ALDH9A1	0.0954965425259052
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1157	31/9376	1.04564083976915	CS/PCCA/ACAT1/MDH2	0.0954965425259052
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/1157	155/9376	0.99335879778069	HLA-DRB5/HLA-E/C1R/HLA-G/HLA-DRA/HGS/ACTG1/SCARB1/HLA-DPB1/ITGB1/TUBA3E/DYNC1LI2/DYNC1LI1/ATP6V1E1/ATP6V0D1/SEC61A1/MRC2/HLA-DOA/EEA1	-0.0312799730266216
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/1157	139/9376	0.991102018989821	KRT18/KRT19/EGFR/MMP2/PIK3CA/SRC/CREB1/GREB1/NCOA1/RARA/CREB3/CREB3L1/MAP2K2/AKT2/KRT14/POMC/SHC1	-0.0396530164624874
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/1157	148/9376	0.985587142890514	EGFR/WNT4/PIK3CA/BAK1/WNT5A/ARAF/NOTCH1/NCOA1/DVL2/DDB2/MAP2K2/AKT2/TCF7/TCF7L2/CDK4/SHC1/WNT10B/TP53	-0.0663086175070086
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/1157	82/9376	0.988258110757426	HLA-DRB5/CD74/HLA-E/HLA-G/HLA-DRA/PSME3/CREB1/HLA-DPB1/PSME1/HLA-DOA	-0.0400669606100335
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1157	32/9376	1.01296456352636	BAK1/BECN1/FADD/BCL2L11	0.0275619094657444
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1157	49/9376	0.992291817331946	RELA/MAOA/CREB1/MAOB/CREB3/CREB3L1	-0.0202965338346496
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1157	69/9376	0.939561334285321	GAB2/MAPK14/PIK3CA/PDPK1/MAP2K2/AKT2/PLCG2/FYN	-0.189050305651564
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1157	52/9376	0.935044212485872	LRPAP1/APOA1/SCARB1/SOAT1/VAPB/STAR	-0.176222443674822
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/1157	95/9376	0.938325069371787	HLA-DRB5/FLT1/HLA-DRA/ACP5/HLA-DPB1/CTSK/IL15/LTB/ATP6V1E1/ATP6V0D1/HLA-DOA	-0.226681414206967
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1157	17/9376	0.953378412730693	SEPHS1/KYAT3	-0.0721837798526979
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1157	53/9376	0.917401868854063	ATP2B4/PRKCB/AP2A2/RAB11A/CLTB/AP2A1	-0.226241953088696
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/1157	62/9376	0.914935734798004	CRYAB/FOXO1/PIK3CA/HDAC2/INSR/AKT2/HDAC1	-0.252126044414568
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1157	27/9376	0.900412945356766	FADS1/ELOVL1/ACAA1	-0.194421825979293
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1157	18/9376	0.900412945356766	TCN2/ZNF76	-0.158668401901684
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1157	54/9376	0.900412945356766	CENPX/RPA2/MUS81/USP1/ERCC4/RPA3	-0.27535188002214
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/1157	54/9376	0.900412945356766	HLA-DRB5/HLA-E/HLA-G/HLA-DRA/HLA-DPB1/HLA-DOA	-0.27535188002214
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/1157	115/9376	0.916072300928188	EGFR/GATA3/ARAF/CREB1/ARHGEF1/GNA12/PRKCB/MEF2D/CREB3/CREB3L1/NACA/RXRB/RXRA	-0.33975677243272
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/1157	98/9376	0.909600832554283	MTMR14/MTMR2/PIK3CA/INPP1/PRKCB/DGKZ/PIP5K1A/ITPK1/PLCG2/PIP4K2B/INPP5F	-0.337515025832176
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/1157	98/9376	0.909600832554283	ATP2B4/CYP11A1/KCNK3/SCARB1/CREB1/PRKCB/HSD3B1/CREB3/CREB3L1/POMC/STAR	-0.337515025832176
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1157	72/9376	0.900412945356766	MAPK14/RELA/NFKBIB/OTUD5/IRF3/TRADD/IKBKG/FADD	-0.318256375755449
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/1157	150/9376	0.918421204263901	EGFR/WNT4/PIK3CA/BAK1/WNT5A/ARAF/DVL2/RXRB/DDB2/MAP2K2/AKT2/TCF7/TCF7L2/SHC1/RXRA/WNT10B/TP53	-0.377884450718217
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1157	37/9376	0.876077460347123	GFPT1/GOT2/ASS1/ALDH4A1	-0.283363434022945
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1157	37/9376	0.876077460347123	MIF/MAOA/GOT2/MAOB	-0.283363434022945
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/1157	99/9376	0.900412945356766	HLA-DRB5/KRT18/KRT19/C1R/HLA-DRA/CFD/HLA-DPB1/FGG/KRT14/SELPLG/HLA-DOA	-0.373731354137208
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/1157	82/9376	0.889432299681683	GSTP1/MGST2/GUSB/NME6/GSTA1/UMPS/UCK2/UCK1/CES2	-0.377291217952649
Cellular Processes	Cell motility	hsa04814	Motor proteins	22/1157	194/9376	0.918978160724946	MYL9/TPM1/MYL6/TPM2/DCTN5/ACTG1/KIF13A/TUBA3E/DYNLL2/MYO9A/KIF1C/DYNC1LI2/DYNC1LI1/KIF21A/DCTN2/MYO18A/MYO19/DYNLRB1/ACTR1A/MYL6B/DCTN1/TUBG1	-0.427835823517492
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1157	38/9376	0.853022790337988	PIK3CA/PDPK1/PRKCB/INSR	-0.340610231184193
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	9/1157	83/9376	0.878716247878289	PEX14/PRDX5/MPV17/ABCD1/ECI2/PEX6/ECH1/NUDT7/ACAA1	-0.416395981099494
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/1157	144/9376	0.900412945356766	BMI1/WNT4/MAPK14/PIK3CA/WNT5A/DVL2/MAP2K2/ID4/AKT2/TCF7/BMP4/PCGF1/BMPR2/BMPR1A/WNT10B/ZFHX3	-0.451834161891199
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1157	144/9376	0.900412945356766	FOXO1/MAPK14/RELA/ALDH7A1/IRF3/TRADD/IKBKG/ALDH9A1/FADD/AKT2/TCF7/LPIN1/TCF7L2/MAP3K5/IL17RC/CPT1A	-0.451834161891199
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/1157	170/9376	0.905709492094158	MYL9/MYL6/ARPC1A/ACTG1/CLDN5/SRC/TJP1/ITGB1/WAS/TUBA3E/ARPC5L/JAM2/PRKCI/TIAM1/CDK4/CLDN19/MAP3K5/SYNPO/MYL6B	-0.465478662741617
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	14/1157	128/9376	0.886343993085566	AK3/HDDC2/GUK1/AK2/DGUOK/CANT1/NUDT5/NME6/ENTPD6/ADK/NUDT16/NUDT2/PRPS2/ENPP1	-0.485753899419609
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1157	10/9376	0.810371650821089	BPNT1	-0.225096641371902
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/1157	181/9376	0.895438288200098	HLA-DRB5/CD74/HLA-DRA/MAPK14/RELA/SRC/PPP3CA/CREB1/HLA-DPB1/TRADD/PPP3CB/CREBBP/FADD/AKT2/KSR1/ATP6V0D1/LSP1/MRC2/HLA-DOA/EEA1	-0.532940754763549
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/1157	67/9376	0.846656948619048	ARAF/PPP3CA/PPP3CB/PRKCB/CREBBP/RPS6KA3/MAP2K2	-0.472599017798541
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/1157	138/9376	0.880838750892488	MAPK14/CDC16/BTRC/PPP3CA/ANAPC13/PPP3CB/PPP2R5A/SMC3/RPS6KA3/PPP2R5B/YWHAE/FBXW11/SLK/ANAPC16/YWHAQ	-0.529088642203525
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1157	21/9376	0.771782524591513	PPCS/ENPP1	-0.392807232621774
NA	NA	hsa04981	Folate transport and metabolism	3/1157	31/9376	0.78423062982686	MTHFD1/FOLR2/SLC46A1	-0.451464717536946
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1157	50/9376	0.810371650821089	CD81/HBB/HBA2/ACKR1/PECAM1	-0.504409652043925
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1157	87/9376	0.838315500849402	MT-CYB/MT-CO2/MT-CO3/TPM1/COX7A1/TPM2/COX4I1/COX6C/COX7A2L	-0.568442260725853
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1157	41/9376	0.790606488605941	MAOA/ALDH7A1/BPGM/MAOB	-0.504127994215023
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/1157	105/9376	0.848960777050665	IL1R1/RELA/CCL21/TRADD/PRKCB/IKBKG/CSNK2B/CSNK2A2/LTB/PLCG2/TRAF5	-0.583934223173771
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/1157	168/9376	0.868255340165452	PRL/PRLR/EGFR/CSF2RB/CSH1/PIK3CA/CSF2RA/CCND3/IL15/CREBBP/PTPN11/IL2RB/AKT2/STAT5B/PDGFA/PIAS3/OSMR/FHL1	-0.646469192594794
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1157	115/9376	0.845605200856788	PIK3CA/CREB1/PRKCB/CREB3/CREB3L1/GNB2/AKT2/KCNQ3/FYN/GNG11/GNB1/GNG12	-0.62502224197057
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/1157	133/9376	0.853022790337988	HLA-E/HLA-G/PIK3CA/TNFSF10/ARAF/PPP3CA/PPP3CB/PRKCB/PTPN11/MAP2K2/PLCG2/SHC1/FYN/TYROBP	-0.640489728723394
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	23/1157	212/9376	0.879176790985144	FLT1/F2R/EGFR/RASGRP2/KDR/MAPK14/ACTG1/PIK3CA/SRC/SIPA1L2/ITGB1/CRKL/PRKCB/CNR1/INSR/PRKCI/MAP2K2/TIAM1/AKT2/PDGFA/CRK/KRIT1/EFNA1	-0.667603467761421
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/1157	42/9376	0.771782524591513	SLC40A1/GPX4/GCLC/TP53	-0.556137872525206
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1157	52/9376	0.779203510404893	CYP11A1/SCARB1/HSD3B1/INSR/STAR	-0.599012011713493
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1157	12/9376	0.675309709017574	COQ6	-0.42225232576055
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/1157	99/9376	0.818557223051605	TPM1/TPM2/ITGB8/ITGA1/ACTG1/ITGB1/DTNA/ITGB7/SNTB2/ITGA3	-0.680920376350803
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1157	23/9376	0.70467100071399	GOT2/ASS1	-0.532031531549252
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1157	23/9376	0.70467100071399	RXYLT1/POMGNT1	-0.532031531549252
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/1157	109/9376	0.8178062531222	MAPK14/RELA/PIK3CA/IRF3/TOLLIP/CTSK/IKBKG/FADD/MAP2K2/AKT2/TLR7	-0.717827285307242
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1157	13/9376	0.623362808323915	XRCC5	-0.509835643938618
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/1157	93/9376	0.78423062982686	EGFR/MMP2/MAPK14/SRC/ELK1/MAP3K3/PRKCB/MAP3K4/MAP2K2	-0.784566789068906
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/1157	103/9376	0.786768593030184	COL6A3/COL17A1/COL6A2/COL4A2/COL1A1/COL5A1/COL18A1/COL4A1/COL14A1/COL1A2	-0.816399034529508
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/1157	103/9376	0.786768593030184	SERPINE1/MAPK14/RELA/PIK3CA/IKBKG/CD3D/FADD/AKT2/CD3E/CD3G	-0.816399034529508
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1157	75/9376	0.756346874099683	TTF1/CREB1/PRKCB/CREB3/CREB3L1/GPX8/GPX3	-0.794841664975522
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1157	46/9376	0.70467100071399	GUSB/ALAD/FECH/UROS	-0.753333039829458
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1157	56/9376	0.723546116804544	BTRC/CSNK1G1/FBXW11/MGRN1/GAS1	-0.778487384920369
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1157	56/9376	0.723546116804544	EEF1A1/RELA/SAR1A/VCP/HBS1L	-0.778487384920369
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1157	36/9376	0.675309709017574	HK1/GAA/ENPP1	-0.732301530985773
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1157	66/9376	0.736701500746445	HLA-DRB5/HLA-DRA/RELA/GATA3/HLA-DPB1/HLA-DOA	-0.805356815714156
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/1157	195/9376	0.831150411098553	MAPK14/ACTG1/RELA/PIK3CA/SRC/CLCN3/PRKCB/HDAC2/HDAC3/HDAC6/FGG/VWF/MAP2K2/AKT2/SLC25A6/PLCG2/SELPLG/HDAC1/HMGB1/TLR7	-0.893953948662672
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1157	105/9376	0.771782524591513	TPM1/TPM2/ITGB8/ITGA1/ACTG1/ITGB1/DTNA/ITGB7/SNTB2/ITGA3	-0.882313822959987
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/1157	134/9376	0.786181452289116	CALD1/MYL9/RAMP1/MYL6/ARAF/ARHGEF1/GNA12/PRKCB/MAP2K2/RAMP2/RAMP3/MYL6B/PPP1R12C	-0.935314398318521
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1157	48/9376	0.675309709017574	HK1/PIK3CA/PRKCB/AKT2	-0.846132700984245
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1157	38/9376	0.639767092753491	IKBKG/CD3D/CD3E	-0.834816595712667
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1157	79/9376	0.718050829841471	NAPA/AP2A2/CLTB/ATP6V1E1/ATP6V0D1/SYT1/AP2A1	-0.944182133886379
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/1157	89/9376	0.728423955794237	EGFR/GJA1/SRC/TJP1/PRKCB/TUBA3E/MAP2K2/PDGFA	-0.965809707104205
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1157	89/9376	0.728423955794237	SRC/GABARAP/PRKCB/TRAK2/GNB2/GNG11/GNB1/GNG12	-0.965809707104205
NA	NA	hsa04081	Hormone signaling	22/1157	219/9376	0.814071977993788	PRL/RAMP1/PRLR/SLC40A1/NPR3/CSH1/ADRA2C/DIO2/PIK3CA/SRC/TRH/GNA12/GNB2/INSR/STAT5B/RAMP2/POMC/GNG11/GNB1/BMPR1A/RAMP3/GNG12	-1.04455936444078
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1157	28/9376	0.578836893443635	ATP6V1E1/ATP6V0D1	-0.837361157906635
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1157	16/9376	0.506482281763181	ST3GAL2	-0.741255013430568
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/1157	166/9376	0.781081109225146	MYL9/ATP2B4/ADRA2C/PPP3CA/CREB1/GNA12/NFATC3/PPP3CB/MEF2D/CREB3/CREB3L1/INSR/MAP2K2/AKT2/SLC25A6/SRF	-1.06770258786047
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1157	51/9376	0.635585608487129	PLPP1/PAFAH2/PLPP3/GDPD3	-0.979036797235797
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1157	63/9376	0.643152103826261	PTGDS/HPGD/GPX4/PTGES/PTGR2	-1.06623133430852
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/1157	216/9376	0.78786132718717	APOA1/MAPK14/RELA/PIK3CA/SRC/TNFSF10/PPP3CA/PDPK1/IRF3/ARHGEF1/POU2F1/NFATC3/PPP3CB/IKBKG/PTK2/RXRB/AKT2/MAP3K5/RXRA/TP53/CASP6	-1.18342792688868
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1157	94/9376	0.689678000698799	MAPK14/RELA/TRADD/IKBKG/FADD/TRAF3IP2/IL17RC/TRAF5	-1.13448442203284
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/1157	154/9376	0.736701500746445	MYL9/MYL6/EEF2/EGFR/ACTG1/SRC/ELK1/PPP3CA/NFATC3/PPP3CB/PRKCB/MAP2K2/MYL6B/PPP1R12C	-1.23605846353392
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/1157	183/9376	0.752804265790083	EMG1/NVL/WDR75/CSNK2B/POP4/POP5/CSNK2A2/WDR43/UTP14C/NOP56/EIF6/GAR1/UTP4/RRP7A/DKC1/FCF1/POP7	-1.26701195941117
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1157	66/9376	0.613917917288704	HSD11B1/CYP11A1/HSD17B11/HSD3B1/SRD5A3	-1.18091761866531
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1157	20/9376	0.405185825410545	SOAT1	-0.999065651811915
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1157	45/9376	0.540247767214059	ABCD1/ABCB7/ABCB8	-1.15986872106991
NA	NA	hsa04519	Cadherin signaling	41/1157	404/9376	0.822406873358036	KRT18/KRT8/KRT7/KRT19/EGFR/GJA1/KDR/CDH11/WNT4/MAPK14/ARPC1A/ACTG1/RELA/DSP/WNT5A/LHFPL6/TJP1/TEAD1/ARPC5L/IKBKG/CREBBP/WWTR1/TAOK1/PTK2/LATS2/RERE/DVL2/MAP2K2/NCKAP1/TCF7/BRK1/TCF7L2/KRT14/YWHAE/APH1B/TAOK2/DSG2/WNT10B/VANGL1/ATN1/YWHAQ	-1.36903651210409
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/1157	78/9376	0.623362808323915	C1R/MAPK14/RELA/IRF3/SERPING1/ITGB1	-1.25319473265159
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1157	47/9376	0.517258500524099	HK1/PIK3CA/INSR	-1.24476923203996
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/1157	60/9376	0.540247767214059	ARAF/GNA12/PRKCB/MAP2K2	-1.34037882946361
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1157	23/9376	0.352335500356995	LNPEP	-1.16675956817042
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1157	73/9376	0.555049075904855	GSTP1/MGST2/MAOA/GSTA1/MAOB	-1.43187418752059
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1157	24/9376	0.337654854508787	B3GAT3	-1.21893502652314
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1157	39/9376	0.415575205549276	MTHFD1/ALDH7A1	-1.37214524300699
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1157	86/9376	0.565375570340295	CREB1/PRKCB/CREB3/CREB3L1/SLC2A1/TRPM4	-1.51914185636913
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/1157	217/9376	0.709541998414778	EGFR/RELA/PIK3CA/MGST2/SRC/CCND3/CREB1/PRKCB/GSTA1/CREB3/KPNB1/CREB3L1/RPS6KA3/PAQR7/RXRB/MAP2K2/AKT2/STAT5B/RXRA	-1.62417196516328
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/1157	65/9376	0.498690246659132	PIK3CA/PRKCB/MAP2K2/AKT2	-1.52162451519782
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1157	26/9376	0.311681404161957	ACAA1	-1.31860038664668
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1157	99/9376	0.572990056136124	IL1R1/MAPK14/PIK3CA/SRC/PRKCB/PLCG2/HRH1	-1.60248744299159
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/1157	191/9376	0.678845361944368	MAOA/ARAF/CREB1/HDAC2/HDAC3/HDAC6/MAOB/CREB3/CREB3L1/GNB2/SLC29A1/SHC1/HDAC1/GNG11/GNB1/GNG12	-1.68241886380453
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/1157	110/9376	0.589361200597156	MAPK14/CDC16/PIK3CA/ARAF/ANAPC13/RPS6KA3/AKT2/ANAPC16	-1.62537285938937
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1157	91/9376	0.534310978563355	PRKCB/GNB2/GRK6/GNG11/GNB1/GNG12	-1.6748216612445
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1157	29/9376	0.279438500283134	GNB1	-1.45806457562283
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1157	115/9376	0.563736800571192	MAOA/ARAF/PRKCB/MAOB/GNB2/GNG11/GNB1/GNG12	-1.76608412012197
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1157	70/9376	0.463069514754908	HSD11B1/GSTP1/MGST2/GSTA1	-1.69171961912599
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/1157	168/9376	0.627073301230605	TNFSF10/CAPN1/RBCK1/TRADD/VPS4A/VPS4B/CAPN2/SHARPIN/FADD/STAT5B/SLC25A6/HMGB1/TRAF5	-1.82994606501138
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/1157	298/9376	0.707035668501621	PRL/IL1RL1/PRLR/CXCL14/IL1R1/IL1R2/CSF2RB/EBI3/CSH1/TNFRSF11B/CCL21/TNFSF10/INHA/CSF2RA/IL15/TNFRSF21/BMP8B/IL2RB/BMP4/ACVRL1/LTB/IL17RC/BMPR2/BMPR1A/OSMR/RELL1	-1.92828231577121
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/1157	59/9376	0.412053381773435	PIK3CA/INSR/AKT2	-1.69968594138843
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/1157	140/9376	0.578836893443635	SERPINE1/RPS6/BECN1/MEF2D/GNB2/MAP2K2/AKT2/GNG11/GNB1/GNG12	-1.88371503268855
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/1157	97/9376	0.50126081494088	CREB1/PRKCB/GNB2/GNG11/GNB1/GNG12	-1.85247177038206
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/1157	61/9376	0.398543434830044	ATP2B4/SLC40A1/SLC46A1	-1.76815602451131
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/1157	187/9376	0.606695353555895	MAPK14/RELA/MFN2/NFKBIB/RBCK1/IRF3/GABARAP/TRIP6/IKBKG/SHARPIN/FADD/YWHAE/BRCC3/TRAF5	-2.03825530850343
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1157	79/9376	0.410314759909412	HSD11B1/GSTP1/MGST2/GSTA1	-1.97471859199651
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1157	36/9376	0.225103236339191	GUSB	-1.74769034413611
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1157	116/9376	0.489017375495485	PPP3CA/PPP3CB/PRKCB/GNB2/GNG11/GNB1/GNG12	-2.07765034922132
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1157	68/9376	0.35751690477401	ALDH1A2/DHRS4L2/DHRS3	-1.9949444250333
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/1157	69/9376	0.352335500356995	PPP3CA/CREB1/PPP3CB	-2.0258748297853
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/1157	154/9376	0.526215357676032	TPM1/TPM2/ATP2B4/MAPK14/CREB1/PPP2R5A/CREB3/CREB3L1/AKT2/PPP2R5B	-2.22418858708715
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/1157	323/9376	0.627222639954403	TIMP3/TPM1/EGFR/ZEB1/BMI1/PIK3CA/BAK1/TNXB/NOTCH1/CRKL/PRKCB/HDAC2/CREBBP/RASSF1/MAP2K2/BCL2L11/PAK4/PDGFA/CRK/PLCG2/SHC1/HDAC1/EFNA1/BMPR2/TP53	-2.5579812503191
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1157	143/9376	0.45335476969012	HLA-DRB5/C1R/HLA-DRA/HLA-DPB1/SNRPD1/SNRPB/SNRPD3/HLA-DOA	-2.47141109178908
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1157	100/9376	0.324148660328436	CXCL14/CCL21/TNFSF10/IL2RB	-2.54925709364029
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/1157	254/9376	0.542374726927501	FLT1/F2R/EGFR/ATP2B4/KDR/STIM1/PPP3CA/NFATC3/PPP3CB/PRKCB/SLC25A6/PDGFA/PLCG2/TPCN1/HRH1/TPCN2/PHKG2	-2.77411622775739
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/1157	102/9376	0.317792804243564	ATP2B4/PRKCB/RAB11A/TPCN2	-2.59911600444468
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/1157	226/9376	0.502000137676781	MYL9/FXYD1/F2R/ATP2B4/RELA/PIK3CA/CREB1/CREB3/CREBBP/CREB3L1/MAP2K2/TIAM1/AKT2/POMC	-2.84325441825447
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/1157	90/9376	0.27012388360703	SCARB1/SLC2A1/RXRA	-2.61035091895803
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/1157	76/9376	0.213255697584497	ACTG1/PRKCB	-2.58369804004832
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/1157	93/9376	0.261410209942287	CST3/ATP2B4/PRKCB	-2.68561297444429
NA	NA	hsa04082	Neuroactive ligand signaling	9/1157	199/9376	0.366499741577377	TAC3/ADRA2C/PRKCB/GNB2/POMC/GNG11/GNB1/HRH1/GNG12	-3.38895495363365
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1157	370/9376	0.306627111121493	PRL/NPW/PRLR/F2R/TAC3/CSH1/ADRA2C/RXFP1/TRH/PGRMC1/CNR1/POMC/PGRMC2/HRH1	-5.10557399455611
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/1157	449/9376	0.0180483663879975	GNB1	-8.00024574586982