category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	51/610	238/9376	3.29367681498829	RPL13A/C1QB/C1QA/RPS26/RPS20/RPL37A/RPS11/RPS28/RPL28/RPL18A/RPS8/RPL10/RPS27/RPL7/RPL31/RPS14/RPL23/RPL36/RPS16/RPLP2/RPS4Y1/EGFR/RPLP0/RPL27A/PIK3CB/RPS15/C1QC/PLCG2/RPS29/MAPK3/UBA52/IL6ST/C5AR1/RPS17/RPL8/RPS9/CYBB/FGG/RPS2/RPL18/RPL13/RPL21/VWF/IRF3/IL1B/RPS5/ACE/RPSA/RPL4/FCGR2A/RPL15	9.45463895085956
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	33/610	155/9376	3.27242728714966	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/CTSL/CD14/ITGA5/HLA-E/HLA-DPB1/HLA-DQA1/CYBA/HLA-DQB1/HLA-DMB/HLA-DMA/SCARB1/ITGB2/TUBA1C/CYBB/CTSS/DYNC1I2/OLR1/FCGR3A/NCF1/MSR1/RAC1/MRC1/ITGB1/ATP6V0B/ATP6AP1/FCGR2A/MRC2/CORO1A	7.52517590474379
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/610	204/9376	2.71243972999036	FN1/TIMP3/CTSL/EZR/ITGA5/EGFR/HSPG2/PXN/IQGAP1/PIK3CB/PLCG2/TIAM1/MAPK3/KDR/RDX/HCLS1/ITPR2/TGFB1/VAV3/ERBB3/SDC1/ERBB2/FGFR1/CAMK2G/WNT7A/VEGFA/PTPN6/RAC1/RRAS2/ITGB1/FLNA/GRB2/PDCD4/MET/CBL/WNT3	6.52301201538723
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	20/610	78/9376	3.94115174443043	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQA1/CYBA/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/ITGB2/CYBB/TGFB1/FCGR3A/NCF1/PTPN6/IL1B/ITGB1/FCGR2A	6.88049660414986
NA	NA	hsa04518	Integrin signaling	29/610	154/9376	2.89444326165638	FN1/FLT1/FLNB/FBN1/ITGA5/EGFR/PXN/PIK3CB/LIMS2/ITGB4/RAC3/PGF/KDR/ITGB2/FGG/CDH1/TGFB1/ACTN4/ERBB2/VWF/LAMB3/VEGFA/RAC1/ITGB1/FLNA/MET/LAMA5/LAMA3/FERMT1	6.25286751158549
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	22/610	99/9376	3.41566484517304	HLA-DRA/KRT19/C1QB/KRT18/C1QA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/KRT14/C1QC/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/C5AR1/ITGB2/FGG/FCGR3A/FPR3/SELPLG/FCGR2A	6.37382772065736
Genetic Information Processing	Translation	hsa03010	Ribosome	36/610	222/9376	2.49251218431546	RPL13A/RPS26/RPS20/RPL37A/RPS11/RPS28/RPL28/RPL18A/RPS8/RPL10/RPS27/RPL7/RPL31/RPS14/RPL23/RPL36/RPS16/RPLP2/RPS4Y1/RPLP0/RPL27A/RPS15/RPS29/UBA52/RPS17/RPL8/RPS9/RPS2/RPL18/RPL13/RPL21/MRPS18A/RPS5/RPSA/RPL4/RPL15	5.93661303005319
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	24/610	116/9376	3.18010175240249	CLDN19/CLDN4/EZR/F11R/JAM2/PXN/CLDN7/PIK3CB/PTK2B/PLCG2/CYBA/CXCR4/AFDN/CLDN5/VASP/ITGB2/CYBB/THY1/ACTN4/VAV3/NCF1/RAC1/ITGB1/PECAM1	6.23232493126474
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	29/610	160/9376	2.78590163934426	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/PTPRF/CLDN19/CLDN4/F11R/HLA-E/HLA-DPB1/JAM2/CLDN7/HLA-DQA1/PVR/HLA-DQB1/HLA-DMB/HLA-DMA/CLDN5/ITGB2/CDH1/PTPRC/PDCD1LG2/SDC1/ITGB1/MAG/SELPLG/PECAM1/CD34	6.01029953923998
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/610	95/9376	3.39768766177739	FLT1/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CTSL/ACP5/HLA-DPB1/HLA-DQA1/CCL5/HLA-DQB1/HLA-DMB/HLA-DMA/CCL3/ITGB2/TGFB1/VEGFA/IL1B/LTB/ATP6V0B/ATP6AP1	6.19593491827886
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/610	44/9376	4.54128166915052	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/GZMB/IL1B	6.2108246372348
Human Diseases	Immune disease	hsa05310	Asthma	11/610	32/9376	5.28360655737705	HLA-DRA/PRG2/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQA1/FCER1G/HLA-DQB1/HLA-DMB/HLA-DMA	6.40277103406926
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/610	45/9376	4.44036429872495	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/GZMB/IL1B	6.10234022074391
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/610	39/9376	4.72938209331652	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/GZMB	6.15623695924633
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/610	181/9376	2.46267548229327	CD74/HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/CTSD/CD14/HLA-DPB1/HLA-DQA1/FCER1G/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/ITGB2/CTSS/TGFB1/FCGR3A/CAMK2G/IL1B/MRC1/BAD/LSP1/KSR1/ATP6V0B/ATP6AP1/FCGR2A/MRC2/CORO1A	5.2415680064693
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/610	109/9376	2.96128741164085	HLA-DRA/EBI3/HLA-DRB1/GATA3/HLA-DPA1/HLA-DRB5/IL2RB/HLA-DPB1/HLA-DQA1/IL1RAP/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/TGFBR1/IL6ST/TGFB1/IL1B/RXRA/IL27RA/IL2RG	5.4329377737899
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/610	110/9376	2.93436661698957	FLT1/EGLN3/SLC2A1/EGFR/SERPINE1/EPAS1/HMOX1/GAPDH/PIK3CB/PLCG2/ELOB/MAPK3/EIF4EBP1/CYBB/ENO1/ERBB2/CAMK2G/VEGFA/PFKP/INSR/PFKL	5.38317881018423
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/610	203/9376	2.3472179601066	FN1/FLT1/FLNB/ITGA5/EGFR/PXN/PIK3CB/ITGB4/RAC3/PGF/PAK2/MAPK3/KDR/VASP/PIP5K1C/ACTN4/VAV3/DIAPH1/ERBB2/RAPGEF1/VWF/LAMB3/VEGFA/RAC1/ITGB1/BAD/FLNA/GRB2/MET/LAMA5/LAMA3	5.11893964045739
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/610	205/9376	2.32431827269092	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/CTSD/SLC2A1/MT-ATP6/MT-ND5/GAPDH/COX4I1/PIK3CB/CYBA/MT-ND4L/TGFBR1/UQCRC1/ATP5F1D/PRKCZ/CYBB/MT-ATP8/TGFB1/NDUFB10/CAMK2G/NCF1/RAC1/INSR/NDUFA3/ACE/NDUFS7	5.05720755143167
NA	NA	hsa04517	IgSF CAM signaling	40/610	299/9376	2.05625308405066	PTPRF/EZR/ITGA5/F11R/JAM2/PXN/IQGAP1/RASA1/PIK3CB/PLCG2/LYN/NECTIN4/PVR/IL1RAP/PAK2/MAPK3/KDR/RDX/AFDN/ITGB2/TUBA1C/FGG/CDH1/ACTN4/VAV3/ARPC2/FGFR1/CD84/PTPN6/RAC1/GIT1/ITGB1/FOXO1/MAG/EPB41L3/GRB2/MYH10/SRGAP2/ARPC1B/PARD6B	4.896460315317
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	27/610	170/9376	2.44119575699132	CLDN19/CLDN4/EZR/F11R/PRKAG2/JAM2/CLDN7/TIAM1/LLGL2/RDX/AFDN/CLDN5/VASP/PRKCZ/HCLS1/TUBA1C/ACTN4/ERBB2/ARPC2/AMOT/RAC1/ITGB1/MYH10/SYNPO/PATJ/ARPC1B/PARD6B	5.00220830363249
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/610	142/9376	2.59782960055414	TYROBP/ACP5/CSF1R/PIK3CB/PLCG2/CYBA/MAPK3/TGFBR1/ITPR2/PPARG/TGFB1/FCGR3A/TNFRSF11B/NCF1/IL1B/RAC1/LILRB3/FHL2/FOSL2/SPI1/LILRB4/GRB2/FCGR2A/TREM2	5.06092057967804
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/610	82/9376	3.18656537385046	CD74/HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/CTSL/HLA-E/HLA-DPB1/HLA-DQA1/CTSB/TAPBP/HLA-DQB1/HLA-DMB/HLA-DMA/CTSS/PSME1	5.24587431342733
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/610	100/9376	2.92039344262295	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/IL1R2/CD14/ITGA5/CSF1R/HLA-DPB1/CSF2RA/HLA-DQA1/CD9/HLA-DQB1/HLA-DMB/HLA-DMA/IL7R/CD37/IL1B/CD34	5.09283571518755
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/610	70/9376	3.29367681498829	EGLN3/SLC2A1/EPAS1/PIK3CB/ELOB/PAK2/MAPK3/TGFB1/RAPGEF1/ARNT2/VEGFA/RAC1/BAD/GRB2/MET	5.08100407376445
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/610	70/9376	3.29367681498829	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/HLA-DQA1/RAC3/DAG1/HLA-DQB1/HLA-DMB/HLA-DMA/ITGB2/RAC1	5.08100407376445
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	32/610	233/9376	2.11096883135158	FN1/FBLN1/TPM1/DSP/FBN1/PKP2/ITGA5/DSG2/HSPG2/JUP/FMNL2/ITGB4/DSC2/DAG1/TPM3/PLEC/INF2/COL27A1/ENO1/BGN/TNNT3/SYNE2/DIAPH1/FBN2/SDC1/SUN2/TNNI2/NEBL/FHL2/ITGB1/COL5A1/MYH10	4.52986540389543
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/610	66/9376	3.26040735221063	HLA-DRA/HLA-DRB1/GATA3/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/TGFB1/IL1B/STAT4/IL2RG	4.86108999112148
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/610	250/9376	2.02890491803279	PSAP/HEXB/VAMP8/CTSL/CTSD/ACP5/CD68/GAA/GM2A/CTSZ/CLTB/CTSB/LAPTM5/TPP1/NPC2/AP1B1/CTSS/AP2B1/CTSA/AP2A2/CTSH/HGSNAT/SLC29A3/AP1M2/AP3D1/DNASE2/CTSW/ATP6V0B/ATP6AP1/GLB1/FUCA2/SLC17A5/FUCA1	4.34965526259991
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/610	93/9376	2.80965979199718	PTPRF/TCF7L2/EGFR/IQGAP1/NECTIN4/RAC3/MAPK3/TGFBR1/AFDN/CDH1/ACTN4/ERBB2/FGFR1/PTPN6/RAC1/INSR/MET	4.62640936808477
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/610	232/9376	2.05381571509327	FN1/EZR/ITGA5/EGFR/PXN/IQGAP1/PIK3CB/TIAM1/ITGB4/RAC3/SSH2/CXCR4/PAK2/MAPK3/RDX/ITGB2/PIP5K1C/ACTN4/VAV3/DIAPH1/ARPC2/CHRM5/LPAR2/FGFR1/RAC1/GIT1/RRAS2/ITGB1/SSH3/MYH10/ARPC1B	4.28736419809493
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/610	212/9376	2.1025672749768	FLT1/CSF1R/EGFR/EFNA1/FYB1/PIK3CB/TIAM1/RAC3/PGF/MAPK3/KDR/AFDN/VASP/PRKCZ/ITGB2/CDH1/VAV3/ADCY7/RAPGEF1/GNAQ/LPAR2/FGFR1/VEGFA/RAC1/INSR/ITGB1/MET/RALGDS/PARD6B	4.28331792729951
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	27/610	193/9376	2.15027605538096	CCL4/PXN/PIK3CB/PTK2B/PLCG2/TIAM1/CCL5/LYN/CCL18/RAC3/CXCR4/MAPK3/CCL3/CXCR6/PRKCZ/CCL4L2/VAV3/CCR1/XCR1/ADCY7/GNAQ/CCL21/NCF1/RAC1/BAD/GRB2/CXCL16	4.25930033373442
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/610	78/9376	2.95586380832282	FN1/ITGA5/PXN/CLTB/PIK3CB/HCLS1/CDH1/ARPC2/DNM2/ELMO3/RAC1/ITGB1/MET/CBL/ARPC1B	4.57552532501205
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	26/610	184/9376	2.17191732002851	SEMA3B/RHOD/EFNA1/RASA1/PIK3CB/PLCG2/PLXNB2/RAC3/SSH2/CXCR4/PAK2/MAPK3/EPHB2/PRKCZ/EFNB1/SEMA7A/CAMK2G/RAC1/ITGB1/BMPR2/MET/SSH3/DPYSL2/SRGAP2/SEMA3A/PARD6B	4.23497351890459
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/610	54/9376	3.41566484517304	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/GZMB	4.69600804532954
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/610	32/9376	4.32295081967213	GAA/GALE/AKR1B1/PGM1/UGP2/PFKP/GALM/GLB1/PFKL	4.9668644799305
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/610	227/9376	2.03134252906767	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/EGFR/MT-ATP6/MT-ND5/HMOX1/COX4I1/PIK3CB/CYBA/MT-ND4L/MAPK3/UQCRC1/ATP5F1D/MT-ATP8/GSTA1/NDUFB10/VEGFA/NCF1/RAC1/BAD/MGST2/GRB2/MET/NDUFA3/NDUFS7	4.14933848657963
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/610	98/9376	2.66630980260957	ASAP3/PIK3CB/PLCG2/LYN/MAPK3/VASP/PIP5K1C/PTPRC/MYO10/FCGR3A/VAV3/ARPC2/DNM2/NCF1/RAC1/FCGR2A/ARPC1B	4.3741273742374
NA	NA	hsa03272	Virion - Hepatitis viruses	11/610	48/9376	3.5224043715847	CLDN19/CLDN4/EGFR/HSPG2/CLDN7/CD9/SCARB1/CLDN5/DPP4/TGOLN2/LDLR	4.62158433991964
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	34/610	275/9376	1.90035171385991	MT-CO2/C1QB/C1QA/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/COX4I1/PIK3CB/C1QC/CCL5/CYBA/MT-ND4L/MAPK3/UQCRC1/ATP5F1D/ATF4/TUBA1C/CYBB/ITPR2/MT-ATP8/PSMC3/NDUFB10/NCF1/IL1B/RAC1/PSMD1/BAD/NDUFA3/NDUFS7	3.99745706513111
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/610	138/9376	2.33898788310763	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/ATP5ME/MT-ATP6/MT-ND5/COX4I1/MT-ND4L/UQCRC1/ATP5F1D/MT-ATP8/NDUFB10/ATP6V0B/ATP6AP1/NDUFA3/NDUFS7/LHPP	4.18000723775244
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	36/610	298/9376	1.85683793596655	TNFSF10/EBI3/IL1R2/INHA/CSF2RB/PRL/IL2RB/CCL4/CSF1R/GDF15/PRLR/CSF2RA/CCL5/CSH1/CCL18/IL1RAP/CXCR4/CCL3/TGFBR1/CXCR6/IL6ST/CCL4L2/TGFB1/TNFRSF11B/CCR1/XCR1/IL7R/CCL21/TNFRSF1B/IL17RE/IL1B/LTB/BMPR2/IL27RA/IL2RG/CXCL16	3.96516762661724
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/610	50/9376	3.38150819672131	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQA1/CXCR4/HLA-DQB1/HLA-DMB/HLA-DMA/TGFB1	4.45388705597608
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/610	93/9376	2.64438568658558	HLA-DRA/HLA-DRB1/GATA3/HLA-DPA1/HLA-DRB5/IL2RB/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/RUNX3/RBPJ/STAT4/IL2RG	4.20388482896452
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/610	112/9376	2.47025761124122	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/BIRC7/TGFB1/LAMB3/ITGB1/BAD/LAMA5/LDLR/LAMA3	4.12907714501621
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/610	71/9376	2.81431540060032	SLC16A3/SLC2A1/EGFR/PIK3CB/IDH2/MAPK3/PKM/SLC1A5/ERBB2/FGFR1/PFKP/MET/PFKL	4.04793560623124
NA	NA	hsa04382	Cornified envelope formation	27/610	217/9376	1.91245750547707	KRT7/KRT8/KRT19/KRT18/COL17A1/DSP/PRSS8/CLDN19/CLDN4/PKP2/DSG2/S100A11/S100A10/CLDN7/PKP3/KRT14/JUP/ITGB4/PLEC/PCSK6/CLDN5/LAMB3/S100A13/TCHH/LAMA5/LAMA3/SLC27A1	3.5873050409833
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/610	106/9376	2.32007423445716	IL1R2/TCF7L2/EGFR/PIK3CB/FOLR1/FOLR2/MAPK3/ATF4/GSTP1/ERBB2/FGFR1/CCNE1/BAD/FOXO1/GRB2/SPINT1	3.60546465602318
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/610	68/9376	2.71243972999036	TCF7L2/CD14/CSF1R/PIK3CB/JUP/MAPK3/EIF4EBP1/CEBPA/BAD/ZBTB16/SPI1/GRB2	3.73844836719072
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/610	138/9376	2.11622713233547	FN1/ITGA5/PXN/FYB1/PIK3CB/PTK2B/RAC3/MAPK3/PIP5K1C/VAV3/ARPC2/GNAQ/IRF3/PKN1/IL1B/RAC1/ITGB1/FCGR2A/ARPC1B	3.4846002349992
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/610	52/9376	2.95586380832282	APOA1/SOAT1/TSPO/SCARB1/LRPAP1/NPC2/PLTP/APOC3/LDLR/NCEH1	3.73068836269453
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/610	250/9376	1.78297704918033	HLA-G/IL2RB/HLA-E/EGFR/RAB11FIP1/CLTB/ASAP3/FOLR1/IQSEC1/FOLR2/CXCR4/TGFBR1/PRKCZ/PIP5K1C/AP2B1/SH3GL1/ACAP1/CHMP4C/ARPC2/AP2A2/DNM2/GIT1/SH3GLB2/PSD4/IL2RG/LDLR/CBL/ARPC1B/PARD6B	3.31000482432686
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/610	100/9376	2.3055737704918	TNFSF10/IL2RB/CCL4/CSF1R/CCL5/CCL18/CXCR4/CCL3/IL6ST/CCL4L2/CCR1/XCR1/CCL21/TNFRSF1B/IL2RG	3.46234921427932
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/610	101/9376	2.28274630741763	FN1/SERPINE1/PIK3CB/PLCG2/MAPK3/TGFBR1/PRKCZ/CYBB/TGFB1/DIAPH1/PLCD3/VEGFA/IL1B/RAC1/FOXO1	3.41896239028256
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	38/610	362/9376	1.61347704012318	FN1/FLT1/PRL/ITGA5/IL2RB/CSF1R/EGFR/PRLR/EFNA1/PIK3CB/CSH1/ITGB4/YWHAE/PGF/MAPK3/KDR/EIF4EBP1/ATF4/ERBB3/ERBB2/VWF/IL7R/LPAR2/FGFR1/LAMB3/VEGFA/CCNE1/PKN1/RAC1/INSR/ITGB1/BAD/RXRA/GRB2/MET/IL2RG/LAMA5/LAMA3	3.14010119735428
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/610	133/9376	2.08021693578208	TNFSF10/HLA-G/TYROBP/HLA-E/PIK3CB/PTK2B/PLCG2/RAC3/FCER1G/MAPK3/ITGB2/HCST/FCGR3A/VAV3/GZMB/PTPN6/RAC1/GRB2	3.30963536411576
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/610	103/9376	2.23842113639981	FN1/IL1R2/CD14/HSPB1/PIK3CB/ITGB2/SERPINB6/TGFB1/ACTN4/GNAQ/LAMB3/IL1B/LAMA5/LAMA3/SERPINB9	3.3337011173428
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	26/610	224/9376	1.78407494145199	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/IL1R2/SLC2A1/IL2RB/HLA-E/HLA-DPB1/PIK3CB/HLA-DQA1/TSPO/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/TGFBR1/ATF4/ITGB2/TGFB1/ADCY7/CCNE1/ANAPC11/SPI1/IL2RG	3.13309382237311
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/610	157/9376	1.95802443353869	TCF7L2/SERPINE1/YWHAE/LLGL2/TGFBR1/TEAD1/PRKCZ/ITGB2/CDH1/TGFB1/WNT7A/AMOT/DVL1/BMPR2/DLG5/PATJ/NKD2/WNT3/NKD1/PARD6B	3.19326033736167
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/610	65/9376	2.60116015132409	CYP11A1/HSD3B1/SCARB1/ATF4/ITPR2/ADCY7/GNAQ/KCNK3/POMC/LDLR/NCEH1	3.41698530164629
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	35/610	333/9376	1.61551715650076	FN1/HLA-G/TCF7L2/ITGA5/HLA-E/EGFR/HES2/PXN/PIK3CB/BCAP31/ITGB4/LLGL2/MAPK3/EIF4EBP1/PKM/PRKCZ/VWF/IRF3/LAMB3/WNT7A/VEGFA/CCNE1/ITGB1/RBPJ/BAD/FOXO1/GRB2/DVL1/ATP6V0B/ATP6AP1/LAMA5/PATJ/LAMA3/WNT3/PARD6B	3.01686472165174
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/610	137/9376	2.01948067488333	TNFSF10/CSF2RB/CTSL/CTSD/ENDOG/CTSZ/PIK3CB/CTSB/MAPK3/ATF4/TUBA1C/CTSS/ITPR2/CTSH/GZMB/BAD/CFLAR/CTSW	3.17085673556676
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	26/610	227/9376	1.76049685852531	HLA-G/HLA-E/CCL4/EGFR/PXN/PIK3CB/PTK2B/TAPBP/CCL5/RAC3/CXCR4/MAPK3/CCL3/EIF4EBP1/ATF4/ITPR2/CCL4L2/CCR1/ADCY7/GNAQ/IRF3/AKAP13/VEGFA/IL1B/RAC1/GRB2	3.05966135892273
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/610	142/9376	1.94837220041561	IL1R2/CTSL/HMOX1/PIK3CB/RAC3/CYBA/KDR/PRKCZ/GSTP1/SDC1/GSTA1/VEGFA/NCF1/IL1B/RAC1/MGST2/BMPR2/PECAM1	3.0038474594621
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/610	18/9376	4.2695810564663	HEXB/MAN2B2/GLB1/FUCA2/FUCA1	3.66257615082607
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/610	60/9376	2.56174863387978	PXN/HSPB1/PIK3CB/PLCG2/RAC3/MAPK3/KDR/VEGFA/RAC1/BAD	3.20126659290699
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/610	80/9376	2.3055737704918	EGFR/PIK3CB/PLCG2/MAPK3/KDR/EIF4EBP1/ERBB3/ERBB2/VEGFA/BAD/GRB2/MET	3.09348614219812
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/610	155/9376	1.88412480169223	CYP11A1/TCF7L2/HSD3B1/EGFR/MAPK3/SCARB1/ATF4/ITPR2/ADCY7/GNAQ/CAMK2G/WNT7A/CCNE1/KCNK3/DVL1/POMC/LDLR/WNT3/NCEH1	2.92779209794912
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/610	71/9376	2.38134380050797	F11R/EGFR/JAM2/PLCG2/CCL5/LYN/RAC1/GIT1/ATP6V0B/MET/ATP6AP1	3.08192872786773
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/610	157/9376	1.86012321186175	MT-CO2/MT-CYB/MT-CO3/PRKAG2/COX4I1/PIK3CB/UQCRC1/ATF4/IRS2/CEBPA/PPARG/TGFB1/NDUFB10/IL1B/RAC1/INSR/RXRA/NDUFA3/NDUFS7	2.86693871422159
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/610	103/9376	2.08919306063982	C1QB/C1QA/SERPINE1/PIK3CB/C1QC/CCL5/MAPK3/CCL3/TGFBR1/TGFB1/GNAQ/IL1B/CFLAR/ACE	2.93199463133578
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/610	388/9376	1.50535744465101	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/GAPDH/COX4I1/PIK3CB/MT-ND4L/MAPK3/SLC39A8/UQCRC1/ATP5F1D/ATF4/IRS2/TUBA1C/CYBB/ITPR2/MT-ATP8/SLC39A4/PSMC3/CHRM5/NDUFB10/GNAQ/WNT7A/IL1B/PSMD1/INSR/BAD/DVL1/NDUFA3/RTN4/NDUFS7/WNT3	2.68183973628996
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/610	205/9376	1.72449420231907	HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-E/HLA-DPB1/PIK3CB/HLA-DQA1/PLCG2/NCOR2/TAPBP/LYN/HLA-DQB1/HLA-DMB/HLA-DMA/PSMC3/RUNX3/IRF3/CCNE1/RAC1/PSMD1/RBPJ	2.76664426255453
Organismal Systems	Immune system	hsa04611	Platelet activation	16/610	126/9376	1.95180848295602	VAMP8/PIK3CB/PLCG2/LYN/FCER1G/MAPK3/VASP/PRKCZ/ITPR2/FGG/SNAP23/ADCY7/VWF/GNAQ/ITGB1/FCGR2A	2.83735580513229
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	28/610	268/9376	1.60587227795449	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/COX4I1/MAOA/MT-ND4L/UBA52/SLC39A8/UQCRC1/ATP5F1D/ATF4/TUBA1C/ITPR2/MT-ATP8/SLC39A4/PSMC3/NDUFB10/CAMK2G/PSMD1/NDUFA3/PINK1/NDUFS7	2.65452481851759
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/610	75/9376	2.25433879781421	GAPDH/IDH2/TPI1/PYCR1/PKM/ENO1/BCAT1/PHGDH/PFKP/SHMT1/PFKL	2.87693790064548
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/610	86/9376	2.144719786504	EGFR/PIK3CB/PLCG2/PAK2/MAPK3/EIF4EBP1/ERBB3/ERBB2/CAMK2G/BAD/GRB2/CBL	2.81313374822103
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/610	200/9376	1.69075409836066	TNFSF10/CLDN19/CLDN4/EZR/GAPDH/CLDN7/BAIAP2L1/PAK2/MAPK3/CLDN5/HCLS1/TUBA1C/MYO10/ARPC2/LPAR2/PTPN6/IL1B/RAC1/ITGB1/FCGR2A/MYH10/ARPC1B	2.60472325998381
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/610	77/9376	2.19578454332553	EGFR/PIK3CB/RAC3/MAPK3/TGFBR1/TGFB1/ERBB2/VEGFA/RAC1/BAD/RALGDS	2.77926524603047
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/610	98/9376	2.03894279023085	CYP11A1/HSD3B1/SCARB1/ATF4/DAGLB/ITPR2/ADCY7/GNAQ/CAMK2G/KCNK3/ATP2B4/POMC/LDLR	2.72726481708164
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/610	201/9376	1.68234238642851	FLT1/HPGD/IL1R2/CD14/IL2RB/CSF1R/ASPSCR1/JUP/NUPR1/CEBPA/PPARG/ARNT2/GZMB/FUS/WT1/FOXO1/RXRA/ZBTB16/SPI1/MET/SPINT1/MYCN	2.57956909322118
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/610	88/9376	2.09597615499255	SERPINE2/C1QB/C1QA/CLU/SERPINE1/C1QC/C5AR1/ITGB2/FGG/VSIG4/VWF/SERPING1	2.72477822902503
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/610	78/9376	2.16763345943674	C1QB/C1QA/CD14/ITGA5/C1QC/MAPK3/ITGB2/IRF3/IL1B/ITGB1/SERPING1	2.7315483017018
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/610	238/9376	1.61454745832759	FLT1/CSF1R/RASGRF2/EGFR/EFNA1/RASA1/PIK3CB/PLCG2/TIAM1/RAC3/PGF/PAK2/MAPK3/KDR/AFDN/FGFR1/VEGFA/RAC1/RRAS2/INSR/BAD/KSR1/GRB2/MET/RALGDS	2.53319225214624
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/610	300/9376	1.53704918032787	FLT1/CD14/CSF1R/RASGRF2/EGFR/EFNA1/HSPB1/RASA1/RAC3/IL1RAP/PGF/PAK2/MAPK3/TGFBR1/KDR/ATF4/TGFB1/ERBB3/ERBB2/TAOK3/FGFR1/VEGFA/IL1B/RAC1/RRAS2/INSR/FLNA/GRB2/STMN1/MET	2.49388983109456
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/610	180/9376	1.70783242258652	CD74/HLA-DRA/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DRB5/ITGA5/HLA-E/HLA-DPB1/PIK3CB/HLA-DQA1/TAPBP/CCL5/HLA-DQB1/HLA-DMB/HLA-DMA/EIF4EBP1/IRF3/IL1B/BAD	2.52939727074661
NA	NA	hsa04519	Cadherin signaling	38/610	404/9376	1.44573932803116	KRT7/KRT8/KRT19/KRT18/DSP/TCF7L2/PKP2/DSG2/EGFR/PKP3/KRT14/JUP/PTK2B/DSC2/RAC3/YWHAE/MAPK3/KDR/TEAD1/AFDN/VASP/LIMA1/CDH1/TMC4/ACTN4/VAV3/ERBB2/ARPC2/TAOK3/FGFR1/WNT7A/RAC1/RRAS2/DVL1/FMN1/MET/WNT3/ARPC1B	2.41588816709511
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/610	138/9376	1.78208600617724	PTPRF/PRKAG2/PIK3CB/FASN/MAPK3/EIF4EBP1/FLOT2/IRS2/PRKCZ/RAPGEF1/PYGL/INSR/BAD/FOXO1/GRB2/CBL	2.44148973086935
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/610	16/9376	3.84262295081967	MIF/MAOA/ALDH3B1/IL4I1	3.00186493363089
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/610	216/9376	1.56551305403764	TNFSF10/CD14/APOA1/PIK3CB/CCL5/LYN/CYBA/MAPK3/CCL3/ATF4/CYBB/PPARG/OLR1/VAV3/IRF3/CAMK2G/NCF1/IL1B/RAC1/BAD/RXRA/LDLR	2.21805134721463
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/610	87/9376	1.94339551535708	TCF7L2/EGFR/PIK3CB/RAC3/MAPK3/TGFBR1/TGFB1/RAC1/BAD/GRB2/RALGDS	2.33194753248647
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/610	157/9376	1.66432076850788	C1QB/C1QA/SLC2A1/C1QC/MAPK3/PPARG/TGFB1/ATP11A/BSG/CAMK2G/PTPN6/RAC1/RXRA/PECAM1/MFGE8/ATP8A2/STAB1	2.21429546794141
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/610	99/9376	1.86308991554893	EGFR/PIK3CB/RAC3/MAPK3/EIF4EBP1/SLC44A2/PIP5K1C/DGKZ/LYPLA1/RAC1/GRB2/RALGDS	2.27729705142583
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/610	36/9376	2.56174863387978	GALNT6/GALNT3/GALNT15/GCNT1/B3GNT3/GALNT2	2.47650249318892
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/610	170/9376	1.62746383799421	TCF7L2/EGFR/HMOX1/PIK3CB/PLCG2/MAPK3/TGFBR1/GSTP1/TXNRD2/TGFB1/GSTA1/WNT7A/BAD/MGST2/GRB2/DVL1/MET/WNT3	2.17784766949093
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/610	67/9376	2.06469292879863	GAPDH/TPI1/PKM/ENO1/ALDH3B1/PGM1/PFKP/GALM/PFKL	2.30706631631191
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/610	89/9376	1.89972370602321	FN1/ITGA5/HSPG2/ITGB4/DAG1/SDC1/VWF/LAMB3/ITGB1/LAMA5/LAMA3	2.24965678907928
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/610	37/9376	2.49251218431546	TCF7L2/TPM3/MAPK3/PPARG/CDH1/RXRA	2.39948689375431
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/610	235/9376	1.50434600627834	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/PRKAG2/ATP5ME/MT-ATP6/MT-ND5/COX4I1/MT-ND4L/UQCRC1/ATP5F1D/MT-ATP8/PPARG/ADCY7/NDUFB10/FGFR1/GRB2/NDUFA3/NDUFS7	2.06545380114672
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/610	91/9376	1.85797153666006	PIK3CB/PLCG2/LYN/RAC3/MAPK3/VAV3/PTPN6/RAC1/LILRB3/LILRB4/GRB2	2.169463985562
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/610	69/9376	2.00484675694939	PIK3CB/PLCG2/LYN/RAC3/FCER1G/MAPK3/VAV3/RAC1/GRB2	2.20988333149339
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/610	150/9376	1.63951912568306	TCF7L2/EGFR/PIK3CB/JUP/MAPK3/TGFBR1/CDH1/TGFB1/ERBB2/WNT7A/CCNE1/RXRA/GRB2/DVL1/MET/WNT3	2.08277455881713
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/610	115/9376	1.73753385602281	GATA3/EGFR/GCM1/MAPK3/ATF4/ITPR2/ADCY7/GNAQ/FGFR1/AKAP13/RXRA/MMP15/MMP14	2.09919006239443
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/610	59/9376	2.0841344818005	TCF7L2/EGFR/PIK3CB/MAPK3/CDH1/ERBB2/BAD/GRB2	2.20353999932073
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	21/610	214/9376	1.50831928910679	HLA-G/HLA-E/PXN/PIK3CB/PTK2B/PLCG2/TAPBP/DDB1/ELOB/RAC3/CXCR4/PAK2/MAPK3/AP1B1/ITPR2/GNAQ/IRF3/TNFRSF1B/AP1M2/RAC1/BAD	1.98425807161861
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/610	143/9376	1.61228934999427	HLA-DRA/C1QB/C1QA/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/C1QC/HLA-DQA1/HLA-DQB1/HLA-DMB/HLA-DMA/ACTN4/FCGR3A/FCGR2A	1.94627018173959
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/610	73/9376	1.89499214013025	EGFR/PIK3CB/PLCG2/MAPK3/ERBB2/BAD/RXRA/GRB2/MET	2.02497172496405
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/610	41/9376	2.24934026389444	EGFR/MAPK3/DAPK1/CDH1/ERBB2/VEGFA	2.11478064247589
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/610	31/9376	2.47911158117398	H6PD/PGM1/PFKP/PGD/PFKL	2.17591514061658
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/610	120/9376	1.66513661202186	ARHGDIB/PIK3CB/PLCG2/YWHAE/MAGED1/MAPK3/ATF4/RAPGEF1/CAMK2G/RAC1/BAD/GRB2/ARHGDIA	1.93437034931235
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/610	86/9376	1.78726648875334	DSP/TCF7L2/PKP2/ITGA5/DSG2/JUP/ITGB4/DSC2/DAG1/ITGB1	1.93469699263186
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/610	42/9376	2.19578454332553	FTL/SAT1/HMOX1/GPX4/SLC39A8/CYBB	2.04877140935118
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/610	122/9376	1.6378392905133	PRKAG2/EEF2/PIK3CB/FASN/EIF4EBP1/IRS2/PPARG/SCD/PFKP/INSR/FOXO1/RAB2A/PFKL	1.87057987808809
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/610	122/9376	1.6378392905133	DIO2/SLC2A1/PIK3CB/PLCG2/MAPK3/THRB/PLCD3/PFKP/THRA/BAD/FOXO1/RXRA/PFKL	1.87057987808809
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/610	76/9376	1.82018981880932	APOA1/FABP7/PPARG/OLR1/SCD/PLTP/RXRA/APOC3/SLC27A1	1.89377996816941
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/610	149/9376	1.54736494663879	EGFR/PIK3CB/PTK2B/PLCG2/FCER1G/MAPK3/PIP5K1C/DGKZ/ADCY7/LPAR2/DNM2/RRAS2/INSR/GRB2/RALGDS	1.776600083176
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/610	44/9376	2.09597615499255	HEXB/MGAT4A/MAN1A2/MGAT1/RPN2/ALG3	1.92216161864425
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/610	253/9376	1.3973174366617	CD14/ITGA5/EGFR/PXN/PIK3CB/PLCG2/CCL5/MAPK3/UBA52/HCLS1/ITPR2/CBX3/ACTN4/DIAPH1/ARPC2/PLCD3/IRF3/CAPNS1/IL1B/RAC1/ITGB1/FOXO1/ARPC1B	1.6899695152819
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	27/610	308/9376	1.34741324249521	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/CLTB/COX4I1/SLC1A3/MT-ND4L/UQCRC1/ATP5F1D/TUBA1C/MT-ATP8/PPARG/AP2B1/POLR2I/PSMC3/AP2A2/NDUFB10/GNAQ/PSMD1/NDUFA3/NDUFS7	1.63536912297239
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/610	15/9376	3.07409836065574	HEXB/ST3GAL5/GLB1	2.12062402681704
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/610	79/9376	1.75106868644947	SLC6A2/CLTB/SLC1A3/SLC1A6/AP2B1/AP2A2/DNM2/SYT1/ATP6V0B	1.76836376963069
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/610	93/9376	1.65274105411599	EGFR/PTK2B/MAPK3/ATF4/ITPR2/ADCY7/GNAQ/CAMK2G/GRB2/MMP14	1.66873759424304
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/610	93/9376	1.65274105411599	FN1/PIK3CB/BIRC7/LAMB3/CCNE1/ITGB1/RXRA/LAMA5/LAMA3/CKS1B	1.66873759424304
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/610	47/9376	1.96219044297175	PIK3CB/MAPK3/PKM/IRS2/PRKCZ/INSR	1.74438459991121
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/610	156/9376	1.47793190416141	CLDN19/CLDN4/EGFR/CLDN7/PIK3CB/YWHAE/MAPK3/SCARB1/CLDN5/IRF3/BAD/CFLAR/RXRA/GRB2/LDLR	1.58786173804263
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/610	107/9376	1.58014401715949	SLC2A1/PRKAG2/ATF4/PKM/ITPR2/GNAQ/PYGL/CAMK2G/PFKP/FOXO1/PFKL	1.5920660750506
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/610	37/9376	2.07709348692955	MIF/MAOA/ALDH3B1/GSTZ1/IL4I1	1.73162519703044
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/610	133/9376	1.50237889806483	TNFSF10/PRKAG2/EGFR/PIK3CB/MAPK3/TGFBR1/IRS2/TGFB1/IL7R/INSR/FOXO1/GRB2/HOMER1	1.53921949577387
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/610	27/9376	2.27710989678203	TECR/SCD/FADS1/ACOT7	1.75298175160918
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/610	109/9376	1.55115054895473	PTPRF/SLC2A1/PRKAG2/PIK3CB/IRS2/PRKCZ/PYGL/INSR/FOXO1/OGA/SLC27A1	1.52673525495993
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/610	50/9376	1.84445901639344	ITGB2/TGFB1/SDC1/IL1B/PECAM1/MET	1.57930385778016
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/610	149/9376	1.44420728352954	MT-ND3/MT-ND2/MT-ND1/MT-ND4/MT-ND5/MT-ND4L/MAPK3/DAGLB/ITPR2/ADCY7/NDUFB10/GNAQ/NDUFA3/NDUFS7	1.44177792478689
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/610	62/9376	1.73537810682179	PRKAG2/PIK3CB/IRS2/ADCY7/INSR/FOXO1/EIF4EBP2	1.53245682156753
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/610	139/9376	1.43752801037858	KRT19/KRT18/CTSD/EGFR/KRT14/PIK3CB/MAPK3/ATF4/ITPR2/ADCY7/GNAQ/GRB2/POMC	1.37087422980561
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/610	205/9376	1.34960415833667	HLA-G/HLA-E/PXN/PIK3CB/DDB1/LYN/YWHAE/MAPK3/IL6ST/ATF4/PKM/ACTN4/IRF3/CCNE1/RAC1/RBPJ/BAD/GRB2	1.33504220700633
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/610	52/9376	1.77351828499369	CYP11A1/HSD3B1/SCARB1/ADCY7/INSR/LDLR	1.47543793789608
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/610	19/9376	2.42691975841242	HEXB/HGSNAT/GLB1	1.64232029574404
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/610	77/9376	1.59693421332766	PIK3CB/MAPK3/TGFBR1/TGFB1/BAD/GRB2/BCR/CBL	1.38740588555714
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/610	30/9376	2.04939890710382	FOLR1/FOLR2/IL1B/SHMT1	1.51858172488094
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/610	53/9376	1.74005567584287	CLTB/AP2B1/AP2A2/GNAQ/DNM2/ATP2B4	1.42519506226512
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/610	248/9376	1.30153358011634	TNFSF10/TCF7L2/CD14/AHNAK2/S100A10/GAPDH/PIK3CB/AHNAK/MAPK3/TUBA1C/PTPRC/DYNC1I2/ARPC2/DNM2/PKN1/IL1B/RAC1/FLNA/GSDMD/PODXL/ARPC1B	1.26947318397796
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/610	90/9376	1.53704918032787	PRKAG2/PIK3CB/EIF4EBP1/ATF4/IRS2/PPARG/ADCY7/INSR/FOXO1	1.35042601481641
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/610	168/9376	1.37236533957845	CSF2RB/PRL/IL2RB/EGFR/PRLR/CSF2RA/PIK3CB/CSH1/IL6ST/IL7R/PTPN6/GRB2/STAT4/IL27RA/IL2RG	1.28466844680727
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/610	116/9376	1.45754663651781	GAPDH/IDH2/TPI1/PKM/ENO1/H6PD/PHGDH/PFKP/SHMT1/PGD/PFKL	1.3080028520888
NA	NA	hsa04981	Folate transport and metabolism	4/610	31/9376	1.98328926493919	FOLR1/FOLR2/SHMT1/SLCO2B1	1.44651291114139
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/610	105/9376	1.46385636221702	CD14/CCL4/PLCG2/LYN/CCL4L2/PPP1R13L/CCL21/IL1B/CFLAR/LTB	1.26085370592741
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/610	55/9376	1.67678092399404	PSAP/HEXB/GM2A/CERK/SGMS2/GLB1	1.3278469559823
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/610	56/9376	1.64683840749415	MGAT4A/MAN1A2/MGAT1/MGAT5/RPN2/ALG3	1.28065361303832
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/610	173/9376	1.33270160144035	HLA-DRA/TNFSF10/HLA-DRB1/HLA-DPA1/HLA-DRB5/HLA-DPB1/PIK3CB/HLA-DQA1/CCL5/HLA-DQB1/HLA-DMB/MAPK3/HLA-DMA/IRF3/IL1B	1.16509960339613
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	37/610	480/9376	1.1848087431694	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/COX4I1/MT-ND4L/MAPK3/UBA52/UQCRC1/ATP5F1D/ATF4/TUBA1C/CYBB/ITPR2/MT-ATP8/PSMC3/CHRM5/NDUFB10/GNAQ/TNFRSF1B/CAMK2G/WNT7A/FUS/IL1B/RAC1/PSMD1/BAD/DVL1/NDUFA3/PINK1/NDUFS7/WNT3	1.09646700568488
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/610	22/9376	2.09597615499255	AOC1/MAOA/ALDH3B1	1.35757423029151
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/610	109/9376	1.41013686268612	CD14/CCL4/PIK3CB/CCL5/MAPK3/CCL3/CCL4L2/IRF3/IL1B/RAC1	1.13611500307693
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/610	163/9376	1.32016494015891	HSPG2/PIK3CB/PTK2B/DDB1/MAPK3/TGFBR1/ATF4/TGFB1/IRF3/CCNE1/BAD/GRB2/STAT4/ATP6AP1	1.08771936804202
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/610	59/9376	1.56310086135038	GPX4/IDH2/GSTP1/GSTA1/MGST2/PGD	1.14452154457517
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/610	35/9376	1.75662763466042	TPI1/AKR1B1/PFKP/PFKL	1.18295808784639
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/610	99/9376	1.3973174366617	TPM1/ITGA5/PRKAG2/ITGB4/DAG1/TPM3/TGFB1/ITGB1/ACE	1.04833785065637
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/610	73/9376	1.47388277565686	EGFR/PIK3CB/MAPK3/CDH1/FGFR1/BAD/MET	1.07218731721261
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/610	195/9376	1.26116855821774	PIK3CB/PLCG2/CYBA/MAPK3/C5AR1/ITGB2/CYBB/FGG/FCGR3A/VWF/NCF1/RAC1/FPR3/SELPLG/GSDMD/FCGR2A	0.972171815271986
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/610	36/9376	1.70783242258652	GAA/PGM1/PYGL/UGP2	1.12242695224308
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/610	101/9376	1.36964778445058	TCF7L2/MAPK3/ADCY7/GNAQ/CAMK2G/WNT7A/DVL1/POMC/WNT3	0.985239143063332
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/610	169/9376	1.27329517896983	VAMP8/CTSL/CTSD/PIK3CB/CTSB/MAPK3/UBA52/DAPK1/IRS2/ATG9B/RRAS2/BAD/CFLAR/EIF2AK4	0.945727622429531
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/610	49/9376	1.56841753094681	GALNT6/GALNT3/GALNT15/PLOD3/GALNT2	1.05231155203271
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/610	75/9376	1.43457923497268	PIK3CB/MAPK3/GSTP1/ERBB2/GSTA1/BAD/MGST2	0.996746233238656
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/610	50/9376	1.53704918032787	AOC1/SAT1/MAOA/PYCR1/SMOX	1.00438721814098
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/610	76/9376	1.41570319240725	EZR/KCNJ2/CA2/ITPR2/ADCY7/GNAQ/CAMK2G	0.959839247490028
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/610	144/9376	1.28087431693989	C1QB/C1QA/TCF7L2/CD14/PRKAG2/C1QC/FASN/C5AR1/SCD/IRF3/IL1B/FOXO1	0.895973572470644
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/610	38/9376	1.61794650560828	HEXB/GALE/PGM1/UGP2	1.00685183699312
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/610	38/9376	1.61794650560828	PIK3CB/MAPK3/SFN/INSR	1.00685183699312
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/610	51/9376	1.50691096110575	GDPD3/PLD3/LPCAT1/LPCAT2/ENPP2	0.957507473903137
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/610	105/9376	1.31747072599532	PIK3CB/PLCG2/FCER1G/MAPK3/ITPR2/IL1B/RRAS2/LSP1/KSR1	0.862948477156782
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/610	122/9376	1.25987637731793	PIK3CB/PLCG2/CSH1/MAPK3/ATF4/IRS2/ITPR2/ADCY7/GNAQ/GRB2	0.76213480328271
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/610	41/9376	1.49956017592963	MAOA/PIPOX/PHGDH/SHMT1	0.845614457757595
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/610	323/9376	1.14207988631173	TIMP3/TPM1/EZR/ITGA5/EGFR/EFNA1/HMOX1/PIK3CB/PLCG2/MAPK3/RDX/IRS2/SLC7A1/ERBB3/ERBB2/SOX4/VEGFA/CCNE1/GRB2/STMN1/BMPR2/PDCD4/MET/WNT3	0.685468377557059
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/610	83/9376	1.29630653762591	CCL4/CCL5/CCL4L2/IRF3/IL1B/DNASE2/GSDMD	0.715240558941681
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/610	254/9376	1.14976119788305	FLT1/EGFR/PTK2B/PLCG2/CXCR4/KDR/ITPR2/ERBB3/ERBB2/ADCY7/PLCD3/CHRM5/P2RX4/GNAQ/FGFR1/CAMK2G/VEGFA/ATP2B4/MET	0.638294279266507
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/610	70/9376	1.31747072599532	SLC2A1/PRKAG2/IRS2/TNFRSF1B/RXRA/POMC	0.703268237941096
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/610	17/9376	1.8082931533269	DAG1/MYH10	0.879890157542178
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/610	99/9376	1.24205994369929	PIK3CB/PLCG2/IL1RAP/ITPR2/ADCY7/GNAQ/CAMK2G/IL1B	0.638684783733218
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/610	44/9376	1.3973174366617	ARHGDIB/DYNC1I2/AQP3/ARHGDIA	0.696829327618381
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/610	157/9376	1.17481466012321	HLA-G/HLA-E/SERPINE1/PIK3CB/MAPK3/TGFBR1/EIF4EBP1/ITPR2/TGFB1/CCNE1/RRAS2/FOXO1	0.582687352240972
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/610	115/9376	1.20290805416964	PIK3CB/MAPK3/ATF4/KCNJ2/ITPR2/ADCY7/CHRM5/GNAQ/CAMK2G	0.577522736636945
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/610	87/9376	1.23670623704541	MT-CO2/TPM1/MT-CYB/MT-CO3/COX4I1/TPM3/UQCRC1	0.585106157933428
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/610	130/9376	1.18234552332913	EGFR/PIK3CB/MAPK3/TGFBR1/ATF4/PRKCZ/TGFB1/ADCY7/VEGFA/GRB2	0.552255004091931
NA	NA	hsa04081	Hormone signaling	16/610	219/9376	1.12295830526237	DIO2/PRL/PRLR/PIK3CB/NPR3/CSH1/TRH/IRS2/THRB/ADCY7/GNAQ/INSR/THRA/GUCA2A/RAMP1/POMC	0.485683267347536
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/610	89/9376	1.20891508565113	EGFR/MAPK3/TUBA1C/ITPR2/ADCY7/GNAQ/GRB2	0.522368408912443
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	26/610	368/9376	1.08595866001426	MT-CO2/MT-ND3/MT-ND2/MT-ND1/MT-CYB/MT-CO3/MT-ND4/MT-ATP6/MT-ND5/COX4I1/MT-ND4L/UQCRC1/ATP5F1D/ATF4/TUBA1C/MT-ATP8/PSMC3/NDUFB10/TNFRSF1B/FUS/RAC1/PSMD1/BAD/NDUFA3/PINK1/NDUFS7	0.443761049420029
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/610	75/9376	1.2296393442623	CD82/SERPINE1/PERP/PPP1R13L/CCNE1/SFN	0.526698316386949
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/610	61/9376	1.25987637731793	FTL/HMOX1/ATOX1/SLC39A4/ATP2B4	0.537143240041305
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/610	90/9376	1.19548269581056	SLC2A1/SCARB1/CA2/ADCY7/RXRA/LDLR/NCEH1	0.491547008242086
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/610	76/9376	1.21345987920621	EGFR/PIK3CB/PLCG2/MAPK3/CAMK2G/GRB2	0.492868887150338
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/610	178/9376	1.12256400810462	NOTUM/SFRP1/TCF7L2/RAC3/GPC4/CAMK2G/WNT7A/TLE3/RAC1/DVL1/NKD2/WNT3/NKD1	0.435487883242578
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/610	105/9376	1.17108508977361	TPM1/ITGA5/ITGB4/DAG1/TPM3/TGFB1/ADCY7/ITGB1	0.465043248386152
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/610	20/9376	1.53704918032787	CYB5R1/UGP2	0.634211002278221
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/610	62/9376	1.23955579058699	NCOR2/TLE3/DTX4/RBPJ/DVL1	0.499211088860988
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/610	78/9376	1.18234552332913	PIK3CB/PLCG2/TPI1/PIP5K1C/PLCD3/INPP5B	0.426577022563986
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/610	196/9376	1.09789227166276	HLA-G/TCF7L2/HLA-E/PIK3CB/PLCG2/LYN/MAPK3/UBA52/IL6ST/ITPR2/CCR1/IRF3/VEGFA/RAC1	0.365346477446948
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/610	65/9376	1.18234552332913	PIK3CB/MAPK3/ITPR2/GNAQ/KISS1R	0.389137821423663
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/610	36/9376	1.28087431693989	DCXR/AKR1B1/UGP2	0.445389181770157
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/610	110/9376	1.11785394932936	FBN1/EMP3/NOG/LTBP1/MAPK3/TGFBR1/TGFB1/BMPR2	0.32797758044113
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/610	125/9376	1.10667540983607	CTSD/PIK3CB/RAC3/FCER1G/MAPK3/PRKCZ/GNAQ/RAC1/SGMS2	0.316719504004476
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/610	37/9376	1.24625609215773	GALE/PGM1/UGP2	0.395901803582689
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/610	37/9376	1.24625609215773	APOA1/GNAQ/IL1B	0.395901803582689
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/610	67/9376	1.14705162711035	MAPK3/ATF4/ITPR2/GNAQ/CAMK2G	0.318643851657733
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/610	23/9376	1.33656450463293	CTSA/ACE	0.426291413560754
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/610	38/9376	1.21345987920621	PTPRC/IL7R/IL2RG	0.347801095325465
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/610	98/9376	1.09789227166276	PIK3CB/PLCG2/PIP5K1C/ITPR2/DGKZ/PLCD3/INPP5B	0.256970981348003
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/610	144/9376	1.06739526411658	PIK3CB/MAPK3/IL6ST/FGFR1/WNT7A/DLX5/GRB2/DVL1/BMPR2/WNT3	0.214987173679727
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/610	99/9376	1.08680245073688	EGFR/PIK3CB/MAPK3/ERBB2/ADCY7/BAD/GRB2	0.229031716810065
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/610	24/9376	1.28087431693989	EXTL3/HS6ST1	0.363425355212159
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/610	69/9376	1.11380375386077	CTSB/KCNJ2/ITPR2/GNAQ/ACE	0.250279972522186
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/610	116/9376	1.0600339174675	SLC38A1/SLC1A3/MAPK3/SLC1A6/ITPR2/ADCY7/GNAQ/HOMER1	0.171620833817434
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/610	10/9376	1.53704918032787	ETHE1	0.44821543070059
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/610	71/9376	1.08242900023089	PRL/PRLR/PIK3CB/MAPK3/GRB2	0.183908092777184
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/610	148/9376	1.03854674346478	TCF7L2/EGFR/PIK3CB/MAPK3/ERBB2/FGFR1/WNT7A/GRB2/DVL1/WNT3	0.124685106582051
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/610	226/9376	1.02016538517336	PIK3CB/TIAM1/FXYD1/RAC3/MAPK3/AFDN/VAV3/ADCY7/CAMK2G/RAC1/RRAS2/BAD/HCAR2/ATP2B4/POMC	0.0809468618817707
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/610	26/9376	1.18234552332913	APOA1/SCARB1	0.245598549044172
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/610	57/9376	1.07863100373886	TECR/FASN/SCD/FADS1	0.157071146606898
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/610	119/9376	1.03331037332966	PIK3CB/CCL5/MAPK3/ATF4/TNFRSF1B/IL1B/CFLAR/MMP14	0.0964645341869601
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/610	73/9376	1.05277341118347	MAOA/GSTP1/GSTA1/ALDH3B1/MGST2	0.119402909461171
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/610	42/9376	1.09789227166276	AOC1/MAOA/IL4I1	0.167721592069877
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/610	105/9376	1.02469945355191	UBA52/ATF4/ATG9B/FKBP8/RRAS2/PINK1/FIS1	0.0671380196155224
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/610	43/9376	1.072359893252	APOA1/SCARB1/SLC27A1	0.125450193325646
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/610	59/9376	1.04206724090025	PIK3CB/IRS2/ADCY7/INSR	0.0855030898296063
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/610	28/9376	1.09789227166276	TECR/ACOT7	0.136841521114594
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/610	28/9376	1.09789227166276	ST3GAL6/B3GNT3	0.136841521114594
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/610	60/9376	1.02469945355191	LYN/MAPK3/ITPR2/GNAQ	0.0506288488451351
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/610	12/9376	1.28087431693989	NECTIN4	0.256815819595345
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/610	140/9376	0.988103044496487	PRKAG2/SERPINE1/MAPK3/TGFBR1/ITPR2/CDH1/ADCY7/GNAQ/RRAS2	-0.037411723464712
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/610	78/9376	0.985287936107608	PABPC1/PABPC4/ENO1/PFKP/PFKL	-0.0344172332635765
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/610	46/9376	1.0024233784747	FTL/HMOX1/BLVRB	0.004346194546547
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/610	46/9376	1.0024233784747	PSMC3/PSMD1/PSME1	0.004346194546547
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/610	174/9376	0.971697757678538	RRBP1/SSR4/SIL1/BCAP31/SEC62/WFS1/ATF4/MAN1A2/PRKCSH/ERP29/RPN2	-0.099404072460163
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/610	79/9376	0.972815936916373	HSD11B1/GSTP1/GSTA1/ALDH3B1/MGST2	-0.0640038829147426
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/610	63/9376	0.975904241478012	HPGD/PTGES/PTGDS/GPX4	-0.050619272363028
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/610	63/9376	0.975904241478012	TCF7L2/WNT7A/DVL1/WNT3	-0.050619272363028
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/610	31/9376	0.991644632469593	ALDH3B1/SMOX	-0.012291547808989
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/610	31/9376	0.991644632469593	HYI/SHMT1	-0.012291547808989
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/610	14/9376	1.09789227166276	B3GNT7	0.096689191499004
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/610	82/9376	0.937225109956018	CDA/GSTP1/UPP1/GSTA1/MGST2	-0.150605688331216
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/610	33/9376	0.931544957774466	IDH2/BCAT1	-0.103912803208292
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/610	33/9376	0.931544957774466	VAMP8/SNAP23	-0.103912803208292
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/610	166/9376	0.925933241161367	MAPK3/ATF4/IRS2/VASP/ITPR2/ADCY7/GNAQ/INSR/BAD/ATP2B4	-0.253978756082394
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/610	51/9376	0.904146576663452	PLCG2/ATP6V0B/ATP6AP1	-0.181058166593479
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/610	34/9376	0.904146576663452	PRKAG2/NR1D2	-0.147698803659727
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/610	102/9376	0.904146576663452	CA2/ITPR2/ADCY7/GNAQ/RAC1/ATP2B4	-0.256758003866064
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/610	16/9376	0.960655737704918	HEXB	-0.0415483035796662
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/610	217/9376	0.920812873007479	EGFR/PIK3CB/KLF5/MAPK3/EIF4EBP1/ATF4/ADCY7/GSTA1/VEGFA/BAD/RXRA/MGST2/GRB2	-0.311322311599303
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/610	86/9376	0.893633244376668	SLC2A1/ATF4/ADCY7/GNAQ/CAMK2G	-0.26139489634106
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/610	103/9376	0.895368454559924	COL17A1/SLC7A8/COL27A1/SLC1A5/DPP4/COL5A1	-0.281657256720365
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/610	70/9376	0.878313817330211	HSD11B1/GSTP1/GSTA1/MGST2	-0.269561947797428
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/610	104/9376	0.886759142496847	PLD3/LPCAT1/DGKZ/LYPLA1/LPCAT2/SGMS2	-0.306325344123993
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/610	154/9376	0.898275494996806	PRKAG2/EGFR/EEF2/MAPK3/KCNJ2/ITPR2/ADCY7/GNAQ/CAMK2G	-0.335755556970573
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/610	187/9376	0.904146576663452	CTSB/CCL5/YWHAE/CYBA/MAPK3/CYBB/ITPR2/IRF3/PKN1/IL1B/GSDMD	-0.349256202898715
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/610	17/9376	0.904146576663452	TXNRD2	-0.10434392944368
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/610	17/9376	0.904146576663452	CA2	-0.10434392944368
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/610	138/9376	0.89104300308862	YWHAE/MAPK3/ITPR2/ADCY7/CAMK2G/CCNE1/CPEB4/ANAPC11	-0.340138280143594
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/610	122/9376	0.881913464122548	PIK3CB/PAK2/MAPK3/PTPRC/VAV3/PTPN6/GRB2	-0.346310271522671
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/610	54/9376	0.853916211293261	BCAT1/PHGDH/IL4I1	-0.283984199393326
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/610	18/9376	0.853916211293261	FASN	-0.163642678159471
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/610	56/9376	0.823419203747073	CD14/ITGB2/IL1B	-0.349606380967014
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/610	194/9376	0.87152273111374	TPM1/KIF21A/TPM3/TUBA1C/MYO10/DYNC1I2/TNNT3/TNNI2/MYO9B/MYH10/MYO7B	-0.476988973133828
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/610	75/9376	0.81975956284153	ATF4/ITPR2/ADCY7/GNAQ	-0.413397517316465
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/610	110/9376	0.838390461997019	PIK3CB/MAPK3/STK10/ADCY7/CPEB4/ANAPC11	-0.449745685673194
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/610	93/9376	0.826370527057994	LYZ/ITPR2/ADCY7/GNAQ/ATP2B4	-0.443885101358194
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/610	20/9376	0.768524590163934	SOAT1	-0.273353460078403
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/610	21/9376	0.731928181108509	CHPF	-0.324405893210573
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/610	21/9376	0.731928181108509	BCAT1	-0.324405893210573
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/610	168/9376	0.823419203747073	TNFSF10/FTL/CYBB/CHMP4C/PYGL/CAMK2G/IL1B/CFLAR/STAT4	-0.609207552762694
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/610	134/9376	0.802936138977245	ADM/MAPK3/ITPR2/ADCY7/GNAQ/RAMP1/MYH10	-0.606074800493203
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/610	63/9376	0.731928181108509	PIPOX/KMT2C/PLOD3	-0.563153071148936
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/610	23/9376	0.668282252316465	PCYOX1	-0.420152528316762
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/610	23/9376	0.668282252316465	CA2	-0.420152528316762
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/610	136/9376	0.791128254580521	IL2RB/PIK3CB/IRF3/CCNE1/IL1B/BAD/IL2RG	-0.647236479575203
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/610	154/9376	0.798467106663828	TPM1/TPM3/MAPK3/ATF4/ADCY7/GNAQ/CAMK2G/ATP2B4	-0.665186710398376
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/610	83/9376	0.740746592929094	PRDX5/IDH2/PIPOX/ABCD1	-0.625799731813658
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/610	45/9376	0.683132969034608	ABCA7/ABCD1	-0.562042347784055
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/610	103/9376	0.746140378799936	PABPC1/PABPC4/UPF2/SRRM1/FUS	-0.683363742727383
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/610	66/9376	0.698658718330849	CYP11A1/HSD3B1/HSD11B1	-0.648045621865916
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/610	158/9376	0.778252749533098	PIK3CB/MAPK3/EIF4EBP1/WNT7A/INSR/GRB2/DVL1/WNT3	-0.741512126348687
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/610	142/9376	0.757700300161625	DDB1/ELOB/UBA52/UBE2K/BIRC7/ANAPC11/CBL	-0.767453260933808
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/610	48/9376	0.640437158469945	BCAT1/IL4I1	-0.658796034589931
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/610	69/9376	0.668282252316465	MAOA/ATF4/CAMK2G	-0.729521706963415
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/610	144/9376	0.747176684881603	PIK3CB/SLC1A6/ITPR2/PSMC3/GNAQ/PSMD1/RBPJ	-0.80649242450665
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/610	49/9376	0.627367012378722	MAOA/ATF4	-0.689855566011791
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/610	90/9376	0.683132969034608	EGFR/PIK3CB/MAPK3/PTPN6	-0.796771501619393
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/610	28/9376	0.548946135831382	AKR1B1	-0.630518587719399
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/610	28/9376	0.548946135831382	CA2	-0.630518587719399
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/610	29/9376	0.530016958733748	TEAD1	-0.668643900761413
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/610	30/9376	0.512349726775956	IDH2	-0.705677114811367
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/610	30/9376	0.512349726775956	PIGT	-0.705677114811367
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/610	31/9376	0.495822316234796	SEC62	-0.74169377728418
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/610	97/9376	0.633834713537266	MAPK3/ADCY7/GNAQ/CAMK2G	-0.956229795382365
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/610	32/9376	0.480327868852459	ATG9B	-0.776761736624553
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/610	32/9376	0.480327868852459	BIRC7	-0.776761736624553
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	19/610	370/9376	0.78929552503323	NPW/ADM/PRL/PRLR/TAC3/CSH1/TSPO/TRH/C5AR1/THRB/PGRMC2/CHRM5/P2RX4/LPAR2/KISS1R/LYNX1/THRA/FPR3/POMC	-1.0908335143473
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/610	34/9376	0.452073288331726	POLR2I	-0.844290344461339
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/610	59/9376	0.521033620450125	CDA/UPP1	-0.973515364915954
NA	NA	hsa04082	Neuroactive ligand signaling	9/610	199/9376	0.695147870500041	SLC6A2/TAC3/SLC1A3/SLC1A6/ADCY7/CHRM5/P2RX4/GNAQ/POMC	-1.14660868750467
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/610	37/9376	0.415418697385911	IL4I1	-0.939821589865059
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/610	38/9376	0.404486626402071	QPRT	-0.970300388009845
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/610	63/9376	0.487952120739006	DDB1/POLR2I	-1.07568686993484
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/610	39/9376	0.394115174443043	SHMT1	-1.00015779097154
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/610	65/9376	0.472938209331652	AKR1B1/DGKZ	-1.12478591868765
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/610	133/9376	0.577838037717244	MAOA/ATF4/ITPR2/GNAQ/CAMK2G	-1.29344589357316
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/610	154/9376	0.598850329997871	QPRT/DHRS3/BCAT1/UGP2/SHMT1/RFK	-1.32404901725398
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/610	43/9376	0.357453297750667	ECI1	-1.11398185369359
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/610	115/9376	0.534625801853172	MAOA/MAPK3/ITPR2/GNAQ	-1.32456142055991
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/610	94/9376	0.490547610742937	MAPK3/IL17RE/IL1B	-1.30947306790184
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/610	158/9376	0.583689562149824	CDKN1C/YWHAE/TGFB1/CCNE1/SFN/ANAPC11	-1.39212205491366
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/610	73/9376	0.421109364473389	CXCR4/SUPT5H	-1.30977370216599
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/610	47/9376	0.327031740495291	PKM	-1.22004482239857
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/610	48/9376	0.320218579234973	PIK3CB	-1.24550496509099
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/610	54/9376	0.284638737097753	CENPX	-1.39064914266507
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/610	83/9376	0.370373296464547	CBX3/BCORL1	-1.51982659231722
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/610	85/9376	0.361658630665381	CDA/UPP1	-1.55948444140399
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/610	89/9376	0.345404310186038	SLC38A1/ADCY7	-1.6367420662961
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/610	117/9376	0.394115174443043	RSF1/BRD9/MBD3	-1.73960556000446
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/610	68/9376	0.226036644165863	DHRS3	-1.68964898046361
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/610	72/9376	0.213479052823315	IRF3	-1.76722364418047
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/610	108/9376	0.284638737097753	UPF2/SRRM1	-1.97239597205107
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/610	191/9376	0.402368895373788	MAOA/MAPK3/ATF4/SLC29A3/GRB2	-2.20120311520967
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/610	91/9376	0.168906503332733	ADCY7	-2.10150026266991
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/610	128/9376	0.24016393442623	ADCY7/PGM1	-2.28323598377916
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/610	243/9376	0.316265263441948	RBM25/SNRPD2/FUS/PRPF6/SF3B2	-2.84861577471292
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/610	183/9376	0.0839917584878617	FBL	-3.30100451599191
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/610	449/9376	0.0342327211654314	CAMK2G	-5.53213427444079