ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0045296 cadherin binding 62/1065 334/18639 0.18562874251497 3.2487644429451 1.13259491788554e-16 1.20734618246599e-13 GO:0003735 structural constituent of ribosome 36/1065 175/18639 0.205714285714286 3.60028973843058 1.44934445677043e-11 7.7250059545864e-09 GO:0038024 cargo receptor activity 21/1065 65/18639 0.323076923076923 5.65430119176598 3.53236124512699e-11 1.25516569576846e-08 GO:0140375 immune receptor activity 32/1065 156/18639 0.205128205128205 3.59003250270856 2.11748940899252e-10 5.64310927496508e-08 GO:0003779 actin binding 60/1065 443/18639 0.135440180586907 2.37039392108861 4.10533831125701e-10 8.75258127959995e-08 GO:0019838 growth factor binding 29/1065 136/18639 0.213235294117647 3.73191797845899 5.67357442334387e-10 1.00800505588076e-07 GO:0023026 MHC class II protein complex binding 12/1065 27/18639 0.444444444444444 7.77840375586854 8.90005343119362e-09 1.35535099395034e-06 GO:0005178 integrin binding 29/1065 161/18639 0.180124223602484 3.15242760913306 3.25395631051157e-08 4.33589678375666e-06 GO:0023023 MHC protein complex binding 13/1065 37/18639 0.351351351351351 6.14914350970689 6.33623171941017e-08 7.50491445876805e-06 GO:0051015 actin filament binding 33/1065 209/18639 0.157894736842105 2.76338028169014 1.03307431226214e-07 1.10125721687144e-05 GO:0019955 cytokine binding 26/1065 144/18639 0.180555555555556 3.1599765258216 1.57586721101883e-07 1.52715858813279e-05 GO:0042277 peptide binding 36/1065 249/18639 0.144578313253012 2.53032411335483 2.65905652279892e-07 2.36212854441971e-05 GO:0001968 fibronectin binding 11/1065 30/18639 0.366666666666667 6.41718309859155 4.02094477526756e-07 3.2971747157194e-05 GO:0001618 virus receptor activity 18/1065 81/18639 0.222222222222222 3.88920187793427 5.41249208373263e-07 4.12122611518499e-05 GO:0140272 exogenous protein binding 18/1065 82/18639 0.219512195121951 3.84177258673995 6.5685064071925e-07 4.66801855337814e-05 GO:0042605 peptide antigen binding 13/1065 45/18639 0.288888888888889 5.05596244131455 8.46548362917549e-07 5.64012846793817e-05 GO:0005201 extracellular matrix structural constituent 27/1065 168/18639 0.160714285714286 2.81272635814889 1.02787638414247e-06 6.4453895617404e-05 GO:0005044 scavenger receptor activity 10/1065 27/18639 0.37037037037037 6.48200312989045 1.2279387837848e-06 7.27212635285888e-05 GO:0019199 transmembrane receptor protein kinase activity 17/1065 78/18639 0.217948717948718 3.81440953412784 1.48652929240786e-06 8.34021171424619e-05 GO:0004896 cytokine receptor activity 19/1065 96/18639 0.197916666666667 3.46382042253521 1.73274154892218e-06 9.23551245575521e-05 GO:0050840 extracellular matrix binding 15/1065 67/18639 0.223880597014925 3.91822577254572 4.28534006777354e-06 0.000217532024392695 GO:0098631 cell adhesion mediator activity 16/1065 76/18639 0.210526315789474 3.68450704225352 4.86306221301893e-06 0.000235637469049008 GO:0015026 coreceptor activity 14/1065 61/18639 0.229508196721311 4.01671669360425 6.54206217637457e-06 0.000303210360000665 GO:0005539 glycosaminoglycan binding 32/1065 242/18639 0.132231404958678 2.31423582819229 8.34282113878998e-06 0.00036628587199708 GO:0009055 electron transfer activity 20/1065 116/18639 0.172413793103448 3.01748421563866 8.59019399617917e-06 0.00036628587199708 GO:0033218 amide binding 32/1065 247/18639 0.129554655870445 2.26738894907909 1.27587967512992e-05 0.000523110666803266 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 14/1065 68/18639 0.205882352941176 3.60323115161558 2.46364857139535e-05 0.000972684954484237 GO:0017124 SH3 domain binding 19/1065 115/18639 0.165217391304348 2.89153704837722 2.67064740693507e-05 0.00101675361992599 GO:0008201 heparin binding 24/1065 172/18639 0.13953488372093 2.44205699312152 4.55454306627057e-05 0.00167418720987739 GO:0098632 cell-cell adhesion mediator activity 12/1065 55/18639 0.218181818181818 3.81848911651729 5.07869603842928e-05 0.00180462999232187 GO:0001540 amyloid-beta binding 15/1065 83/18639 0.180722891566265 3.16290514169353 6.39628942934226e-05 0.00219949823602544 GO:0005006 epidermal growth factor receptor activity 11/1065 50/18639 0.22 3.85030985915493 9.58844695216726e-05 0.00319415139094072 GO:1901681 sulfur compound binding 32/1065 275/18639 0.116363636363636 2.03652752880922 0.000106354846541062 0.00343558383069006 GO:0005010 insulin-like growth factor receptor activity 11/1065 51/18639 0.215686274509804 3.77481358740679 0.000116009037921894 0.00363678376242827 GO:0032395 MHC class II receptor activity 5/1065 10/18639 0.5 8.75070422535211 0.000119406596327382 0.00363678376242827 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/1065 60/18639 0.2 3.50028169014085 0.000124425807084396 0.00368438639866572 GO:0097110 scaffold protein binding 13/1065 70/18639 0.185714285714286 3.2502615694165 0.000145614160448958 0.00419526202806999 GO:0005518 collagen binding 13/1065 72/18639 0.180555555555556 3.1599765258216 0.000195677576580164 0.0054892709640646 GO:0005114 type II transforming growth factor beta receptor binding 5/1065 11/18639 0.454545454545455 7.95518565941101 0.000208607606062231 0.00570194123236765 GO:0030169 low-density lipoprotein particle binding 6/1065 17/18639 0.352941176470588 6.17696768848384 0.000246073998439897 0.00655787205842326 GO:0022804 active transmembrane transporter activity 45/1065 457/18639 0.0984682713347921 1.72333343606497 0.000267587271362231 0.0068092718795274 GO:0070325 lipoprotein particle receptor binding 8/1065 31/18639 0.258064516129032 4.51649250340754 0.000268282756979504 0.0068092718795274 GO:0050431 transforming growth factor beta binding 7/1065 24/18639 0.291666666666667 5.10457746478873 0.000285681360178932 0.00708224023141259 GO:0030228 lipoprotein particle receptor activity 6/1065 18/18639 0.333333333333333 5.83380281690141 0.000351341855002915 0.00722517400705299 GO:0098641 cadherin binding involved in cell-cell adhesion 6/1065 18/18639 0.333333333333333 5.83380281690141 0.000351341855002915 0.00722517400705299 GO:0015078 proton transmembrane transporter activity 23/1065 185/18639 0.124324324324324 2.17585078035782 0.000371582191999848 0.00722517400705299 GO:0005004 GPI-linked ephrin receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0005008 hepatocyte growth factor receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0005009 insulin receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0005011 macrophage colony-stimulating factor receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0005018 platelet-derived growth factor alpha-receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0005020 stem cell factor receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0008288 boss receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0036332 placental growth factor receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0038062 protein tyrosine kinase collagen receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0060175 brain-derived neurotrophic factor receptor activity 10/1065 49/18639 0.204081632653061 3.5717160103478 0.000379558859657568 0.00722517400705299 GO:0008137 NADH dehydrogenase (ubiquinone) activity 9/1065 41/18639 0.219512195121951 3.84177258673995 0.000418347786255205 0.00782383754645699 GO:0016651 oxidoreductase activity, acting on NAD(P)H 14/1065 88/18639 0.159090909090909 2.78431498079385 0.000443725017643446 0.00787227818633089 GO:0005007 fibroblast growth factor receptor activity 10/1065 50/18639 0.2 3.50028169014085 0.000450477457191543 0.00787227818633089 GO:0005017 platelet-derived growth factor receptor activity 10/1065 50/18639 0.2 3.50028169014085 0.000450477457191543 0.00787227818633089 GO:0005019 platelet-derived growth factor beta-receptor activity 10/1065 50/18639 0.2 3.50028169014085 0.000450477457191543 0.00787227818633089 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/1065 13/18639 0.384615384615385 6.73131094257855 0.000527814973752949 0.00886204309962956 GO:0005021 vascular endothelial growth factor receptor activity 10/1065 51/18639 0.196078431372549 3.43164871582436 0.000532055120428041 0.00886204309962956 GO:0005030 neurotrophin receptor activity 10/1065 51/18639 0.196078431372549 3.43164871582436 0.000532055120428041 0.00886204309962956 GO:0061134 peptidase regulator activity 26/1065 226/18639 0.115044247787611 2.013436370435 0.000541176761323765 0.00887529888570974 GO:0051020 GTPase binding 33/1065 315/18639 0.104761904761905 1.83348088531187 0.000583441934331912 0.00942347124239119 GO:0072341 modified amino acid binding 14/1065 91/18639 0.153846153846154 2.69252437703142 0.000628625018165197 0.010001705512897 GO:0003954 NADH dehydrogenase activity 9/1065 44/18639 0.204545454545455 3.57983354673496 0.00072568646699737 0.010991371573937 GO:0005003 ephrin receptor activity 10/1065 53/18639 0.188679245283019 3.30215253786872 0.000732070714586801 0.010991371573937 GO:0005005 transmembrane-ephrin receptor activity 10/1065 53/18639 0.188679245283019 3.30215253786872 0.000732070714586801 0.010991371573937 GO:0038064 collagen receptor activity 10/1065 53/18639 0.188679245283019 3.30215253786872 0.000732070714586801 0.010991371573937 GO:0044548 S100 protein binding 5/1065 14/18639 0.357142857142857 6.25050301810865 0.000782568719083348 0.0115863646464285 GO:0031267 small GTPase binding 30/1065 283/18639 0.106007067137809 1.85527298064002 0.000838162672204984 0.012239471350281 GO:0043394 proteoglycan binding 8/1065 37/18639 0.216216216216216 3.78408831366578 0.000967981366509644 0.0139441640094497 GO:0004629 phospholipase C activity 7/1065 29/18639 0.241379310344828 4.22447790189412 0.00100275790814832 0.0142525324011482 GO:0022853 active monoatomic ion transmembrane transporter activity 16/1065 118/18639 0.135593220338983 2.37307233229888 0.00110229246271863 0.0154611021744482 GO:0016500 protein-hormone receptor activity 11/1065 67/18639 0.164179104477612 2.87336556653353 0.00135789547543467 0.0187989165819916 GO:0030246 carbohydrate binding 29/1065 280/18639 0.103571428571429 1.81264587525151 0.00145396065942543 0.0198707956788142 GO:0004602 glutathione peroxidase activity 6/1065 23/18639 0.260869565217391 4.56558481322719 0.00149417293813461 0.0201618778740696 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 10/1065 58/18639 0.172413793103448 3.01748421563866 0.00151309807530324 0.0201620318534157 GO:0005024 transforming growth factor beta receptor activity 5/1065 16/18639 0.3125 5.46919014084507 0.00155148888739651 0.0204183599254898 GO:0045309 protein phosphorylated amino acid binding 10/1065 59/18639 0.169491525423729 2.9663404153736 0.001730338783076 0.0224944041799881 GO:0071813 lipoprotein particle binding 7/1065 32/18639 0.21875 3.82843309859155 0.0018617286514891 0.0236262231248498 GO:0071814 protein-lipid complex binding 7/1065 32/18639 0.21875 3.82843309859155 0.0018617286514891 0.0236262231248498 GO:0002020 protease binding 17/1065 136/18639 0.125 2.18767605633803 0.00193990655323646 0.024328710420589 GO:0005126 cytokine receptor binding 28/1065 275/18639 0.101818181818182 1.78196158770807 0.00223369341778961 0.0276874091088805 GO:0051219 phosphoprotein binding 13/1065 93/18639 0.139784946236559 2.44643343934575 0.00236945922178538 0.0290326842577381 GO:0048185 activin binding 4/1065 11/18639 0.363636363636364 6.36414852752881 0.002529587373026 0.0304914311575975 GO:0046943 carboxylic acid transmembrane transporter activity 21/1065 188/18639 0.111702127659574 1.95494456098292 0.00254571986212587 0.0304914311575975 GO:0008375 acetylglucosaminyltransferase activity 8/1065 43/18639 0.186046511627907 3.25607599082869 0.0026844094544564 0.0317934713054327 GO:0005342 organic acid transmembrane transporter activity 21/1065 189/18639 0.111111111111111 1.94460093896714 0.00271407681875645 0.0317934713054327 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 5/1065 18/18639 0.277777777777778 4.86150234741784 0.00276620787425362 0.0320519303690691 GO:0016860 intramolecular oxidoreductase activity 9/1065 53/18639 0.169811320754717 2.97193728408185 0.00286334198854307 0.0328206726858808 GO:0004435 phosphatidylinositol phospholipase C activity 6/1065 26/18639 0.230769230769231 4.03878656554713 0.0029426302259935 0.0330194086411482 GO:0050750 low-density lipoprotein particle receptor binding 6/1065 26/18639 0.230769230769231 4.03878656554713 0.0029426302259935 0.0330194086411482 GO:0004857 enzyme inhibitor activity 38/1065 416/18639 0.0913461538461538 1.59868634886241 0.00297784685650094 0.0330665078023959 GO:0008514 organic anion transmembrane transporter activity 27/1065 269/18639 0.100371747211896 1.75664694486622 0.00323368826175858 0.0355372338869552 GO:0001784 phosphotyrosine residue binding 8/1065 47/18639 0.170212765957447 2.9789631405454 0.00475971251940303 0.0517740157722819 GO:0004866 endopeptidase inhibitor activity 18/1065 161/18639 0.111801242236025 1.9566792056688 0.004929550725876 0.0527728238279085 GO:0008035 high-density lipoprotein particle binding 4/1065 13/18639 0.307692307692308 5.38504875406284 0.00500005178857294 0.0527728238279085 GO:0043560 insulin receptor substrate binding 4/1065 13/18639 0.307692307692308 5.38504875406284 0.00500005178857294 0.0527728238279085 GO:0043236 laminin binding 6/1065 29/18639 0.206896551724138 3.62098105876639 0.00524563732448654 0.05428979988255 GO:0051861 glycolipid binding 6/1065 29/18639 0.206896551724138 3.62098105876639 0.00524563732448654 0.05428979988255 GO:0008238 exopeptidase activity 13/1065 102/18639 0.127450980392157 2.23057166528583 0.0053314866983357 0.0546477386579409 GO:0048306 calcium-dependent protein binding 11/1065 80/18639 0.1375 2.40644366197183 0.00564759018590919 0.0573364870302781 GO:0001786 phosphatidylserine binding 9/1065 59/18639 0.152542372881356 2.66970637383624 0.0059845331167756 0.0601840783253094 GO:0015101 organic cation transmembrane transporter activity 11/1065 81/18639 0.135802469135802 2.37673448095983 0.00620664964571948 0.0618344721713736 GO:0004713 protein tyrosine kinase activity 16/1065 140/18639 0.114285714285714 2.00016096579477 0.00629653316315996 0.0621491143697085 GO:0015294 solute:monoatomic cation symporter activity 14/1065 116/18639 0.120689655172414 2.11223895094706 0.00638243685819163 0.0624190613837824 GO:0005085 guanyl-nucleotide exchange factor activity 23/1065 230/18639 0.1 1.75014084507042 0.0065292653568295 0.0632745170034568 GO:0008191 metalloendopeptidase inhibitor activity 4/1065 14/18639 0.285714285714286 5.00040241448692 0.00668704501636878 0.0642197296166587 GO:0015399 primary active transmembrane transporter activity 18/1065 166/18639 0.108433734939759 1.89774308501612 0.00675802919791253 0.0643219564729889 GO:1990782 protein tyrosine kinase binding 14/1065 117/18639 0.11965811965812 2.09418562657999 0.00687993479848539 0.0648302940285763 GO:0004177 aminopeptidase activity 7/1065 40/18639 0.175 3.06274647887324 0.00693307084358133 0.0648302940285763 GO:0004867 serine-type endopeptidase inhibitor activity 12/1065 95/18639 0.126315789473684 2.21070422535211 0.00779970579662084 0.0722998815582418 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/1065 41/18639 0.170731707317073 2.98804534524219 0.00795762772832224 0.0723764640106545 GO:0005125 cytokine activity 23/1065 234/18639 0.0982905982905983 1.72022390754785 0.00798940154061073 0.0723764640106545 GO:0030414 peptidase inhibitor activity 18/1065 169/18639 0.106508875739645 1.86405533794483 0.00809643114970506 0.0723764640106545 GO:0031625 ubiquitin protein ligase binding 28/1065 302/18639 0.0927152317880795 1.6226471411249 0.00811129181175174 0.0723764640106545 GO:0180051 translation factor activity 11/1065 84/18639 0.130952380952381 2.29185110663984 0.00814744435391983 0.0723764640106545 GO:0015179 L-amino acid transmembrane transporter activity 9/1065 62/18639 0.145161290322581 2.54052703316674 0.00829964231222803 0.0731191628498767 GO:0016493 C-C chemokine receptor activity 5/1065 23/18639 0.217391304347826 3.80465401102266 0.0085687890435506 0.0742628383774386 GO:0140103 catalytic activity, acting on a glycoprotein 5/1065 23/18639 0.217391304347826 3.80465401102266 0.0085687890435506 0.0742628383774386 GO:0005041 low-density lipoprotein particle receptor activity 4/1065 15/18639 0.266666666666667 4.66704225352113 0.00871181566550648 0.0742943639954393 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1065 15/18639 0.266666666666667 4.66704225352113 0.00871181566550648 0.0742943639954393 GO:0061135 endopeptidase regulator activity 19/1065 184/18639 0.103260869565217 1.80721065523576 0.00915173057318291 0.0774265459604205 GO:0015293 symporter activity 16/1065 146/18639 0.10958904109589 1.91796256994019 0.00932690189420374 0.0782872237733952 GO:0019956 chemokine binding 6/1065 33/18639 0.181818181818182 3.1820742637644 0.0100740124559413 0.0826069021387187 GO:0030296 protein tyrosine kinase activator activity 6/1065 33/18639 0.181818181818182 3.1820742637644 0.0100740124559413 0.0826069021387187 GO:0140311 protein sequestering activity 6/1065 33/18639 0.181818181818182 3.1820742637644 0.0100740124559413 0.0826069021387187 GO:0019957 C-C chemokine binding 5/1065 24/18639 0.208333333333333 3.64612676056338 0.0103245220907692 0.0833783374906061 GO:0048027 mRNA 5'-UTR binding 5/1065 24/18639 0.208333333333333 3.64612676056338 0.0103245220907692 0.0833783374906061 GO:0031406 carboxylic acid binding 19/1065 187/18639 0.101604278074866 1.77821797092717 0.0107805897188432 0.0864068318818562 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/1065 16/18639 0.25 4.37535211267606 0.0110985912582098 0.0882917782182959 GO:0019843 rRNA binding 9/1065 65/18639 0.138461538461538 2.42327193932828 0.0112387911795292 0.0887448251657639 GO:0043177 organic acid binding 19/1065 189/18639 0.100529100529101 1.75940084954169 0.0119893761836239 0.0939755515569344 GO:0042974 nuclear retinoic acid receptor binding 5/1065 25/18639 0.2 3.50028169014085 0.0123114290138263 0.0957954987499188 GO:0170055 lipid transmembrane transporter activity 8/1065 56/18639 0.142857142857143 2.50020120724346 0.0137063964457193 0.103345824584973 GO:0015291 secondary active transmembrane transporter activity 26/1065 287/18639 0.0905923344947735 1.58549344849585 0.0137973686728615 0.103345824584973 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1065 17/18639 0.235294117647059 4.11797845898923 0.0138688003352605 0.103345824584973 GO:0019198 transmembrane receptor protein phosphatase activity 4/1065 17/18639 0.235294117647059 4.11797845898923 0.0138688003352605 0.103345824584973 GO:0038191 neuropilin binding 4/1065 17/18639 0.235294117647059 4.11797845898923 0.0138688003352605 0.103345824584973 GO:0001221 transcription coregulator binding 13/1065 115/18639 0.11304347826087 1.97842008573178 0.0141604040950665 0.103345824584973 GO:0035401 histone H3Y41 kinase activity 13/1065 115/18639 0.11304347826087 1.97842008573178 0.0141604040950665 0.103345824584973 GO:0140801 histone H2AXY142 kinase activity 13/1065 115/18639 0.11304347826087 1.97842008573178 0.0141604040950665 0.103345824584973 GO:0030695 GTPase regulator activity 40/1065 489/18639 0.081799591002045 1.43160805322734 0.0144474933405357 0.103345824584973 GO:0001637 G protein-coupled chemoattractant receptor activity 5/1065 26/18639 0.192307692307692 3.36565547128927 0.0145420953918817 0.103345824584973 GO:0004950 chemokine receptor activity 5/1065 26/18639 0.192307692307692 3.36565547128927 0.0145420953918817 0.103345824584973 GO:0005160 transforming growth factor beta receptor binding 5/1065 26/18639 0.192307692307692 3.36565547128927 0.0145420953918817 0.103345824584973 GO:0043548 phosphatidylinositol 3-kinase binding 5/1065 26/18639 0.192307692307692 3.36565547128927 0.0145420953918817 0.103345824584973 GO:0060589 nucleoside-triphosphatase regulator activity 40/1065 490/18639 0.0816326530612245 1.42868640413912 0.0148963511924821 0.10516232033898 GO:0004601 peroxidase activity 8/1065 57/18639 0.140350877192982 2.45633802816901 0.015169899017068 0.105693544785585 GO:0016504 peptidase activator activity 8/1065 57/18639 0.140350877192982 2.45633802816901 0.015169899017068 0.105693544785585 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/1065 10/18639 0.3 5.25042253521127 0.0164904336549135 0.113379945217562 GO:0043208 glycosphingolipid binding 3/1065 10/18639 0.3 5.25042253521127 0.0164904336549135 0.113379945217562 GO:0016298 lipase activity 14/1065 130/18639 0.107692307692308 1.88476706392199 0.016592187105009 0.113379945217562 GO:0004364 glutathione transferase activity 5/1065 27/18639 0.185185185185185 3.24100156494523 0.017028204954319 0.114249519522534 GO:0015172 acidic amino acid transmembrane transporter activity 4/1065 18/18639 0.222222222222222 3.88920187793427 0.0170409696098339 0.114249519522534 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/1065 18/18639 0.222222222222222 3.88920187793427 0.0170409696098339 0.114249519522534 GO:0019903 protein phosphatase binding 15/1065 144/18639 0.104166666666667 1.82306338028169 0.0177982177622379 0.11858062584091 GO:0044389 ubiquitin-like protein ligase binding 28/1065 322/18639 0.0869565217391304 1.52186160440906 0.0180236976491878 0.119337029155492 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/1065 59/18639 0.135593220338983 2.37307233229888 0.0184310523727863 0.121280875490063 GO:0017171 serine hydrolase activity 19/1065 198/18639 0.095959595959596 1.67942808365344 0.0188174907857381 0.123064080844152 GO:0008135 translation factor activity, RNA binding 10/1065 83/18639 0.120481927710843 2.10860342779569 0.0196434201048362 0.12551177184004 GO:0030165 PDZ domain binding 10/1065 83/18639 0.120481927710843 2.10860342779569 0.0196434201048362 0.12551177184004 GO:0045499 chemorepellent activity 5/1065 28/18639 0.178571428571429 3.12525150905433 0.0197804668565917 0.12551177184004 GO:0046875 ephrin receptor binding 5/1065 28/18639 0.178571428571429 3.12525150905433 0.0197804668565917 0.12551177184004 GO:0097718 disordered domain specific binding 5/1065 28/18639 0.178571428571429 3.12525150905433 0.0197804668565917 0.12551177184004 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/1065 19/18639 0.210526315789474 3.68450704225352 0.0206306775177771 0.128609954584505 GO:0015245 fatty acid transmembrane transporter activity 4/1065 19/18639 0.210526315789474 3.68450704225352 0.0206306775177771 0.128609954584505 GO:0034987 immunoglobulin receptor binding 4/1065 19/18639 0.210526315789474 3.68450704225352 0.0206306775177771 0.128609954584505 GO:0019215 intermediate filament binding 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0019864 IgG binding 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0042608 T cell receptor binding 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0045294 alpha-catenin binding 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0097493 structural molecule activity conferring elasticity 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0140031 phosphorylation-dependent protein binding 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:1990948 ubiquitin ligase inhibitor activity 3/1065 11/18639 0.272727272727273 4.77311139564661 0.0217257510106214 0.130110396501811 GO:0004222 metalloendopeptidase activity 12/1065 110/18639 0.109090909090909 1.90924455825864 0.0231608982029877 0.137930265275893 GO:0044325 transmembrane transporter binding 14/1065 136/18639 0.102941176470588 1.80161557580779 0.0236189264875578 0.139876531309648 GO:0019207 kinase regulator activity 25/1065 287/18639 0.0871080139372822 1.52451293124601 0.023942313239458 0.141008319962774 GO:0019902 phosphatase binding 18/1065 190/18639 0.0947368421052632 1.65802816901408 0.0244476017622805 0.143193096036214 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/1065 40/18639 0.15 2.62521126760563 0.0249271534680347 0.145204074300136 GO:0004175 endopeptidase activity 33/1065 405/18639 0.0814814814814815 1.4260406885759 0.0257890921848514 0.149408544940498 GO:0005319 lipid transporter activity 17/1065 178/18639 0.0955056179775281 1.67148282956164 0.026330922687351 0.151258894112511 GO:0008081 phosphoric diester hydrolase activity 10/1065 87/18639 0.114942528735632 2.01165614375911 0.0263922648263855 0.151258894112511 GO:0005078 MAP-kinase scaffold activity 3/1065 12/18639 0.25 4.37535211267606 0.0277596750400037 0.155746387329705 GO:0015132 prostaglandin transmembrane transporter activity 3/1065 12/18639 0.25 4.37535211267606 0.0277596750400037 0.155746387329705 GO:0070008 serine-type exopeptidase activity 3/1065 12/18639 0.25 4.37535211267606 0.0277596750400037 0.155746387329705 GO:0097677 STAT family protein binding 3/1065 12/18639 0.25 4.37535211267606 0.0277596750400037 0.155746387329705 GO:0004197 cysteine-type endopeptidase activity 10/1065 88/18639 0.113636363636364 1.98879641485275 0.0283103581961372 0.158004407523991 GO:0016853 isomerase activity 17/1065 180/18639 0.0944444444444444 1.65291079812207 0.0289303613977276 0.159956742821021 GO:0036122 BMP binding 4/1065 21/18639 0.19047619047619 3.33360160965795 0.0291103265546699 0.159956742821021 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/1065 21/18639 0.19047619047619 3.33360160965795 0.0291103265546699 0.159956742821021 GO:0008236 serine-type peptidase activity 18/1065 194/18639 0.0927835051546392 1.62384202119936 0.0293352330776705 0.160365940824599 GO:0042056 chemoattractant activity 6/1065 42/18639 0.142857142857143 2.50020120724346 0.030960659789595 0.16838807824341 GO:0015171 amino acid transmembrane transporter activity 11/1065 102/18639 0.107843137254902 1.8874067937034 0.0311319775592613 0.16846034557448 GO:0016757 glycosyltransferase activity 23/1065 267/18639 0.0861423220973783 1.50761196391834 0.0328177790472915 0.176685618507135 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1065 22/18639 0.181818181818182 3.1820742637644 0.0340168815622335 0.177608761249583 GO:0141108 transporter regulator activity 16/1065 170/18639 0.0941176470588235 1.64719138359569 0.0342729310745614 0.177608761249583 GO:0005172 vascular endothelial growth factor receptor binding 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0017154 semaphorin receptor activity 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0031994 insulin-like growth factor I binding 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0070123 transforming growth factor beta receptor activity, type III 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0071714 icosanoid transmembrane transporter activity 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0140333 glycerophospholipid flippase activity 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0140410 monoatomic cation:bicarbonate symporter activity 3/1065 13/18639 0.230769230769231 4.03878656554713 0.0345875620154329 0.177608761249583 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/1065 91/18639 0.10989010989011 1.92323169787959 0.0346553680486991 0.177608761249583 GO:0015370 solute:sodium symporter activity 9/1065 79/18639 0.113924050632911 1.99383134248529 0.0358594207235946 0.182029249958818 GO:0033293 monocarboxylic acid binding 9/1065 79/18639 0.113924050632911 1.99383134248529 0.0358594207235946 0.182029249958818 GO:0140313 molecular sequestering activity 7/1065 55/18639 0.127272727272727 2.22745198463508 0.036198584298227 0.182880051478246 GO:0001223 transcription coactivator binding 6/1065 44/18639 0.136363636363636 2.3865556978233 0.0378746232987228 0.190243524654082 GO:0008194 UDP-glycosyltransferase activity 14/1065 145/18639 0.096551724137931 1.68979116075765 0.0380130119618381 0.190243524654082 GO:0005283 amino acid:sodium symporter activity 4/1065 23/18639 0.173913043478261 3.04372320881813 0.0393743747240614 0.195223643980695 GO:0017134 fibroblast growth factor binding 4/1065 23/18639 0.173913043478261 3.04372320881813 0.0393743747240614 0.195223643980695 GO:0099106 ion channel regulator activity 15/1065 160/18639 0.09375 1.64075704225352 0.0406530607993347 0.200630383389309 GO:0003823 antigen binding 16/1065 174/18639 0.0919540229885057 1.60932491500729 0.0410781622175026 0.201794105639898 GO:0008009 chemokine activity 6/1065 45/18639 0.133333333333333 2.33352112676056 0.0416721482814337 0.202433896690987 GO:0042562 hormone binding 10/1065 94/18639 0.106382978723404 1.86185196284088 0.0419296970432358 0.202433896690987 GO:0005161 platelet-derived growth factor receptor binding 3/1065 14/18639 0.214285714285714 3.75030181086519 0.0421967939242686 0.202433896690987 GO:0019763 immunoglobulin receptor activity 3/1065 14/18639 0.214285714285714 3.75030181086519 0.0421967939242686 0.202433896690987 GO:0032036 myosin heavy chain binding 3/1065 14/18639 0.214285714285714 3.75030181086519 0.0421967939242686 0.202433896690987 GO:0008376 acetylgalactosaminyltransferase activity 5/1065 34/18639 0.147058823529412 2.57373653686827 0.0423478039043996 0.202433896690987 GO:0019209 kinase activator activity 14/1065 148/18639 0.0945945945945946 1.65553863722878 0.0439707440940096 0.209253630375956 GO:0030215 semaphorin receptor binding 4/1065 24/18639 0.166666666666667 2.9169014084507 0.0451843452507198 0.214073386832299 GO:0008028 monocarboxylic acid transmembrane transporter activity 8/1065 70/18639 0.114285714285714 2.00016096579477 0.0455912557534081 0.21504548067758 GO:0004620 phospholipase activity 11/1065 109/18639 0.100917431192661 1.76619718309859 0.0470337501085255 0.219585473209296 GO:0005154 epidermal growth factor receptor binding 5/1065 35/18639 0.142857142857143 2.50020120724346 0.047171738616256 0.219585473209296 GO:0005343 organic acid:sodium symporter activity 5/1065 35/18639 0.142857142857143 2.50020120724346 0.047171738616256 0.219585473209296 GO:0005504 fatty acid binding 6/1065 47/18639 0.127659574468085 2.23422235540905 0.0499638119158928 0.226493819450548 GO:0004879 nuclear receptor activity 7/1065 59/18639 0.11864406779661 2.07643829076152 0.050145514627123 0.226493819450548 GO:0015459 potassium channel regulator activity 7/1065 59/18639 0.11864406779661 2.07643829076152 0.050145514627123 0.226493819450548 GO:0005516 calmodulin binding 18/1065 207/18639 0.0869565217391304 1.52186160440906 0.0502728384916164 0.226493819450548 GO:0004129 cytochrome-c oxidase activity 3/1065 15/18639 0.2 3.50028169014085 0.0505680384889591 0.226493819450548 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/1065 15/18639 0.2 3.50028169014085 0.0505680384889591 0.226493819450548 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/1065 15/18639 0.2 3.50028169014085 0.0505680384889591 0.226493819450548 GO:0015929 hexosaminidase activity 3/1065 15/18639 0.2 3.50028169014085 0.0505680384889591 0.226493819450548 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/1065 15/18639 0.2 3.50028169014085 0.0505680384889591 0.226493819450548 GO:0120020 cholesterol transfer activity 4/1065 25/18639 0.16 2.80022535211268 0.0514458531053662 0.229461420126864 GO:0098531 ligand-modulated transcription factor activity 7/1065 60/18639 0.116666666666667 2.04183098591549 0.0540957001109497 0.240275067992801 GO:0030295 protein kinase activator activity 13/1065 139/18639 0.0935251798561151 1.63682237308745 0.0548508759561043 0.242618397382603 GO:0016209 antioxidant activity 9/1065 86/18639 0.104651162790698 1.83154274484114 0.0566037386079449 0.249337129570534 GO:0016247 channel regulator activity 15/1065 168/18639 0.0892857142857143 1.56262575452716 0.0577820431669065 0.250177808655074 GO:0019865 immunoglobulin binding 4/1065 26/18639 0.153846153846154 2.69252437703142 0.0581556272350907 0.250177808655074 GO:0070006 metalloaminopeptidase activity 4/1065 26/18639 0.153846153846154 2.69252437703142 0.0581556272350907 0.250177808655074 GO:0016758 hexosyltransferase activity 17/1065 197/18639 0.0862944162436548 1.51027382569529 0.0592119012832509 0.250177808655074 GO:0019887 protein kinase regulator activity 21/1065 255/18639 0.0823529411764706 1.44129246064623 0.0593066056259814 0.250177808655074 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0022841 potassium ion leak channel activity 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0055102 lipase inhibitor activity 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0140327 flippase activity 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0140328 floppase activity 3/1065 16/18639 0.1875 3.28151408450704 0.0596763724652858 0.250177808655074 GO:0048029 monosaccharide binding 8/1065 74/18639 0.108108108108108 1.89204415683289 0.0598455358415045 0.250177808655074 GO:0008237 metallopeptidase activity 16/1065 184/18639 0.0869565217391304 1.52186160440906 0.0622160070188952 0.259071341727118 GO:0043531 ADP binding 5/1065 38/18639 0.131578947368421 2.30281690140845 0.0635178010587799 0.263462941356651 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/1065 27/18639 0.148148148148148 2.59280125195618 0.0653082224143553 0.26673779729388 GO:0015252 proton channel activity 4/1065 27/18639 0.148148148148148 2.59280125195618 0.0653082224143553 0.26673779729388 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1065 27/18639 0.148148148148148 2.59280125195618 0.0653082224143553 0.26673779729388 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/1065 27/18639 0.148148148148148 2.59280125195618 0.0653082224143553 0.26673779729388 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 9/1065 89/18639 0.101123595505618 1.76980534894762 0.0674658795879435 0.273454857949611 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 9/1065 89/18639 0.101123595505618 1.76980534894762 0.0674658795879435 0.273454857949611 GO:0016798 hydrolase activity, acting on glycosyl bonds 12/1065 130/18639 0.0923076923076923 1.61551462621885 0.0684913768814576 0.275385766952668 GO:0003743 translation initiation factor activity 6/1065 51/18639 0.117647058823529 2.05898922949461 0.0693822365088198 0.275385766952668 GO:0005092 GDP-dissociation inhibitor activity 3/1065 17/18639 0.176470588235294 3.08848384424192 0.0694922807788627 0.275385766952668 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/1065 17/18639 0.176470588235294 3.08848384424192 0.0694922807788627 0.275385766952668 GO:0046965 nuclear retinoid X receptor binding 3/1065 17/18639 0.176470588235294 3.08848384424192 0.0694922807788627 0.275385766952668 GO:0048038 quinone binding 3/1065 17/18639 0.176470588235294 3.08848384424192 0.0694922807788627 0.275385766952668 GO:0140297 DNA-binding transcription factor binding 36/1065 488/18639 0.0737704918032787 1.29108750865851 0.0700536473783597 0.276582178167894 GO:0140793 histone H2AXY142 phosphatase activity 9/1065 90/18639 0.1 1.75014084507042 0.0713576706529799 0.28069105873091 GO:0046625 sphingolipid binding 4/1065 28/18639 0.142857142857143 2.50020120724346 0.0728961816739826 0.285688712001711 GO:0005080 protein kinase C binding 6/1065 52/18639 0.115384615384615 2.01939328277356 0.074830557676962 0.291650711034382 GO:0005179 hormone activity 12/1065 132/18639 0.0909090909090909 1.5910371318822 0.0749646292902633 0.291650711034382 GO:0015144 carbohydrate transmembrane transporter activity 5/1065 40/18639 0.125 2.18767605633803 0.0759702061741659 0.29236187646809 GO:0061791 GTPase motor activity 5/1065 40/18639 0.125 2.18767605633803 0.0759702061741659 0.29236187646809 GO:1990606 membrane scission GTPase motor activity 5/1065 40/18639 0.125 2.18767605633803 0.0759702061741659 0.29236187646809 GO:0043178 alcohol binding 9/1065 92/18639 0.0978260869565217 1.7120943049602 0.0795510934221867 0.300216164970087 GO:0052689 carboxylic ester hydrolase activity 9/1065 92/18639 0.0978260869565217 1.7120943049602 0.0795510934221867 0.300216164970087 GO:0017075 syntaxin-1 binding 3/1065 18/18639 0.166666666666667 2.9169014084507 0.0799825430126685 0.300216164970087 GO:0032393 MHC class I receptor activity 3/1065 18/18639 0.166666666666667 2.9169014084507 0.0799825430126685 0.300216164970087 GO:0034185 apolipoprotein binding 3/1065 18/18639 0.166666666666667 2.9169014084507 0.0799825430126685 0.300216164970087 GO:0035615 clathrin adaptor activity 3/1065 18/18639 0.166666666666667 2.9169014084507 0.0799825430126685 0.300216164970087 GO:0099602 neurotransmitter receptor regulator activity 3/1065 18/18639 0.166666666666667 2.9169014084507 0.0799825430126685 0.300216164970087 GO:0005544 calcium-dependent phospholipid binding 6/1065 53/18639 0.113207547169811 1.98129152272123 0.0805150443390311 0.301154516720727 GO:0005416 amino acid:monoatomic cation symporter activity 4/1065 29/18639 0.137931034482759 2.41398737251093 0.0809102017270282 0.301574388255287 GO:0017080 sodium channel regulator activity 5/1065 41/18639 0.121951219512195 2.13431810374442 0.0826554827228815 0.307006078684989 GO:0016769 transferase activity, transferring nitrogenous groups 4/1065 30/18639 0.133333333333333 2.33352112676056 0.0893392991920307 0.328122787051675 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/1065 122/18639 0.0901639344262295 1.57799584391595 0.0895161111346727 0.328122787051675 GO:0008307 structural constituent of muscle 5/1065 42/18639 0.119047619047619 2.08350100603622 0.089641269605758 0.328122787051675 GO:0016859 cis-trans isomerase activity 5/1065 42/18639 0.119047619047619 2.08350100603622 0.089641269605758 0.328122787051675 GO:0005520 insulin-like growth factor binding 3/1065 19/18639 0.157894736842105 2.76338028169014 0.0911110177929605 0.328122787051675 GO:0022840 leak channel activity 3/1065 19/18639 0.157894736842105 2.76338028169014 0.0911110177929605 0.328122787051675 GO:0022842 narrow pore channel activity 3/1065 19/18639 0.157894736842105 2.76338028169014 0.0911110177929605 0.328122787051675 GO:0030506 ankyrin binding 3/1065 19/18639 0.157894736842105 2.76338028169014 0.0911110177929605 0.328122787051675 GO:0097001 ceramide binding 3/1065 19/18639 0.157894736842105 2.76338028169014 0.0911110177929605 0.328122787051675 GO:0032934 sterol binding 7/1065 68/18639 0.102941176470588 1.80161557580779 0.0925485226960368 0.33217752590564 GO:0070851 growth factor receptor binding 12/1065 139/18639 0.0863309352517986 1.51091295977303 0.100615991159187 0.35992163280434 GO:0016004 phospholipase activator activity 3/1065 20/18639 0.15 2.62521126760563 0.102839334731278 0.361701489020255 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/1065 20/18639 0.15 2.62521126760563 0.102839334731278 0.361701489020255 GO:0042288 MHC class I protein binding 3/1065 20/18639 0.15 2.62521126760563 0.102839334731278 0.361701489020255 GO:0016790 thiolester hydrolase activity 5/1065 44/18639 0.113636363636364 1.98879641485275 0.104492526179392 0.361701489020255 GO:0030547 signaling receptor inhibitor activity 5/1065 44/18639 0.113636363636364 1.98879641485275 0.104492526179392 0.361701489020255 GO:0004860 protein kinase inhibitor activity 8/1065 84/18639 0.0952380952380952 1.66680080482897 0.106560299183986 0.361701489020255 GO:0051117 ATPase binding 8/1065 84/18639 0.0952380952380952 1.66680080482897 0.106560299183986 0.361701489020255 GO:0005200 structural constituent of cytoskeleton 10/1065 112/18639 0.0892857142857143 1.56262575452716 0.107160543272265 0.361701489020255 GO:0120015 sterol transfer activity 4/1065 32/18639 0.125 2.18767605633803 0.107391380751153 0.361701489020255 GO:0004725 protein tyrosine phosphatase activity 9/1065 98/18639 0.0918367346938776 1.60727220465651 0.10740928196156 0.361701489020255 GO:0004955 prostaglandin receptor activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0008190 eukaryotic initiation factor 4E binding 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0008239 dipeptidyl-peptidase activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0015187 glycine transmembrane transporter activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0019911 structural constituent of myelin sheath 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0035374 chondroitin sulfate binding 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0043295 glutathione binding 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0050815 phosphoserine residue binding 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0140940 histone H2A methyltransferase activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:1990259 histone H2AQ104 methyltransferase activity 2/1065 10/18639 0.2 3.50028169014085 0.108239000935705 0.361701489020255 GO:0140303 intramembrane lipid transporter activity 5/1065 45/18639 0.111111111111111 1.94460093896714 0.112345073416636 0.37424952581917 GO:0140312 cargo adaptor activity 3/1065 21/18639 0.142857142857143 2.50020120724346 0.115127502760713 0.382323731909408 GO:0008234 cysteine-type peptidase activity 15/1065 187/18639 0.0802139037433155 1.40385629283724 0.116408949836343 0.385378697284292 GO:0050660 flavin adenine dinucleotide binding 8/1065 86/18639 0.0930232558139535 1.62803799541435 0.117790712598477 0.388745819287854 GO:0030276 clathrin binding 5/1065 46/18639 0.108695652173913 1.90232700551133 0.120472393987661 0.396369049354466 GO:0015035 protein-disulfide reductase activity 4/1065 34/18639 0.117647058823529 2.05898922949461 0.126937158583087 0.40111210642542 GO:0001851 complement component C3b binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0002162 dystroglycan binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0004954 prostanoid receptor activity 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0005536 D-glucose binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0008199 ferric iron binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0032050 clathrin heavy chain binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0034713 type I transforming growth factor beta receptor binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0050998 nitric-oxide synthase binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:1900750 oligopeptide binding 2/1065 11/18639 0.181818181818182 3.1820742637644 0.127464167585723 0.40111210642542 GO:0008093 cytoskeletal anchor activity 3/1065 22/18639 0.136363636363636 2.3865556978233 0.127934442949946 0.40111210642542 GO:0015377 chloride:monoatomic cation symporter activity 3/1065 22/18639 0.136363636363636 2.3865556978233 0.127934442949946 0.40111210642542 GO:0140784 metal ion sensor activity 3/1065 22/18639 0.136363636363636 2.3865556978233 0.127934442949946 0.40111210642542 GO:0043495 protein-membrane adaptor activity 5/1065 47/18639 0.106382978723404 1.86185196284088 0.128866272805729 0.402848817627294 GO:0004252 serine-type endopeptidase activity 14/1065 176/18639 0.0795454545454545 1.39215749039693 0.132159391525088 0.411935413350128 GO:0019905 syntaxin binding 6/1065 61/18639 0.0983606557377049 1.72145001154468 0.134182937514087 0.416131908090554 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 11/1065 132/18639 0.0833333333333333 1.45845070422535 0.13428646940258 0.416131908090554 GO:0008083 growth factor activity 13/1065 162/18639 0.0802469135802469 1.40443401147627 0.136290236806126 0.420273143416033 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1065 23/18639 0.130434782608696 2.28279240661359 0.141218453183829 0.420273143416033 GO:0070577 lysine-acetylated histone binding 3/1065 23/18639 0.130434782608696 2.28279240661359 0.141218453183829 0.420273143416033 GO:0071617 lysophospholipid acyltransferase activity 3/1065 23/18639 0.130434782608696 2.28279240661359 0.141218453183829 0.420273143416033 GO:0019210 kinase inhibitor activity 8/1065 90/18639 0.0888888888888889 1.55568075117371 0.142049217126677 0.420273143416033 GO:0017022 myosin binding 7/1065 76/18639 0.0921052631578947 1.61197183098592 0.142896657232816 0.420273143416033 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25/1065 349/18639 0.0716332378223496 1.25368255377537 0.144759084510789 0.420273143416033 GO:0005096 GTPase activator activity 20/1065 271/18639 0.0738007380073801 1.29161685983057 0.14532757431269 0.420273143416033 GO:0004859 phospholipase inhibitor activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0004875 complement receptor activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0005025 transforming growth factor beta receptor activity, type I 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0005026 transforming growth factor beta receptor activity, type II 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0008504 monoamine transmembrane transporter activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0015166 polyol transmembrane transporter activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0016208 AMP binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0016361 activin receptor activity, type I 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0016362 activin receptor activity, type II 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0017002 activin receptor activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0017166 vinculin binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0035259 nuclear glucocorticoid receptor binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0036009 protein-glutamine N-methyltransferase activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0045295 gamma-catenin binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0097371 MDM2/MDM4 family protein binding 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1065 12/18639 0.166666666666667 2.9169014084507 0.147405066094867 0.420273143416033 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/1065 36/18639 0.111111111111111 1.94460093896714 0.147844679907141 0.420273143416033 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1065 36/18639 0.111111111111111 1.94460093896714 0.147844679907141 0.420273143416033 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1065 36/18639 0.111111111111111 1.94460093896714 0.147844679907141 0.420273143416033 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1065 36/18639 0.111111111111111 1.94460093896714 0.147844679907141 0.420273143416033 GO:0005507 copper ion binding 6/1065 63/18639 0.0952380952380952 1.66680080482897 0.149727133772842 0.424492352664495 GO:0004622 lysophospholipase activity 3/1065 24/18639 0.125 2.18767605633803 0.154937611459988 0.434640773200913 GO:0050699 WW domain binding 3/1065 24/18639 0.125 2.18767605633803 0.154937611459988 0.434640773200913 GO:0060229 lipase activator activity 3/1065 24/18639 0.125 2.18767605633803 0.154937611459988 0.434640773200913 GO:0140033 acetylation-dependent protein binding 3/1065 24/18639 0.125 2.18767605633803 0.154937611459988 0.434640773200913 GO:0048020 CCR chemokine receptor binding 5/1065 50/18639 0.1 1.75014084507042 0.155556415535414 0.43523133585499 GO:0005496 steroid binding 9/1065 108/18639 0.0833333333333333 1.45845070422535 0.164354177402667 0.458642809191737 GO:0005542 folic acid binding 2/1065 13/18639 0.153846153846154 2.69252437703142 0.167917339563855 0.461038031056457 GO:0032396 inhibitory MHC class I receptor activity 2/1065 13/18639 0.153846153846154 2.69252437703142 0.167917339563855 0.461038031056457 GO:0045159 myosin II binding 2/1065 13/18639 0.153846153846154 2.69252437703142 0.167917339563855 0.461038031056457 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1065 13/18639 0.153846153846154 2.69252437703142 0.167917339563855 0.461038031056457 GO:0071837 HMG box domain binding 2/1065 13/18639 0.153846153846154 2.69252437703142 0.167917339563855 0.461038031056457 GO:0015271 outward rectifier potassium channel activity 3/1065 25/18639 0.12 2.10016901408451 0.169050123962891 0.461038031056457 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1065 25/18639 0.12 2.10016901408451 0.169050123962891 0.461038031056457 GO:0000146 microfilament motor activity 4/1065 38/18639 0.105263157894737 1.84225352112676 0.169969930774097 0.461038031056457 GO:0005109 frizzled binding 4/1065 38/18639 0.105263157894737 1.84225352112676 0.169969930774097 0.461038031056457 GO:0005501 retinoid binding 4/1065 38/18639 0.105263157894737 1.84225352112676 0.169969930774097 0.461038031056457 GO:0019840 isoprenoid binding 4/1065 38/18639 0.105263157894737 1.84225352112676 0.169969930774097 0.461038031056457 GO:0008235 metalloexopeptidase activity 6/1065 66/18639 0.0909090909090909 1.5910371318822 0.174459889477608 0.472015843104392 GO:0030971 receptor tyrosine kinase binding 7/1065 81/18639 0.0864197530864197 1.51246739697444 0.179810144479297 0.485259782316279 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1065 39/18639 0.102564102564103 1.79501625135428 0.181441942909891 0.487498928222695 GO:0008143 poly(A) binding 3/1065 26/18639 0.115384615384615 2.01939328277356 0.183514623536082 0.487498928222695 GO:0008198 ferrous iron binding 3/1065 26/18639 0.115384615384615 2.01939328277356 0.183514623536082 0.487498928222695 GO:0015145 monosaccharide transmembrane transporter activity 3/1065 26/18639 0.115384615384615 2.01939328277356 0.183514623536082 0.487498928222695 GO:0030247 polysaccharide binding 3/1065 26/18639 0.115384615384615 2.01939328277356 0.183514623536082 0.487498928222695 GO:0034237 protein kinase A regulatory subunit binding 3/1065 26/18639 0.115384615384615 2.01939328277356 0.183514623536082 0.487498928222695 GO:0017046 peptide hormone binding 5/1065 53/18639 0.0943396226415094 1.65107626893436 0.184298375303702 0.487498928222695 GO:0051018 protein kinase A binding 5/1065 53/18639 0.0943396226415094 1.65107626893436 0.184298375303702 0.487498928222695 GO:0005313 L-glutamate transmembrane transporter activity 2/1065 14/18639 0.142857142857143 2.50020120724346 0.18887076383712 0.493471162378358 GO:0008494 translation activator activity 2/1065 14/18639 0.142857142857143 2.50020120724346 0.18887076383712 0.493471162378358 GO:0031404 chloride ion binding 2/1065 14/18639 0.142857142857143 2.50020120724346 0.18887076383712 0.493471162378358 GO:0070742 C2H2 zinc finger domain binding 2/1065 14/18639 0.142857142857143 2.50020120724346 0.18887076383712 0.493471162378358 GO:0098821 BMP receptor activity 2/1065 14/18639 0.142857142857143 2.50020120724346 0.18887076383712 0.493471162378358 GO:0005548 phospholipid transporter activity 6/1065 68/18639 0.0882352941176471 1.54424192212096 0.191813757813066 0.499935124275619 GO:0042578 phosphoric ester hydrolase activity 25/1065 363/18639 0.068870523415978 1.20533116051682 0.192786409306616 0.500996721178097 GO:0015036 disulfide oxidoreductase activity 4/1065 40/18639 0.1 1.75014084507042 0.193161024769416 0.500996721178097 GO:0015485 cholesterol binding 5/1065 54/18639 0.0925925925925926 1.62050078247261 0.194284532640071 0.501470488606091 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1065 54/18639 0.0925925925925926 1.62050078247261 0.194284532640071 0.501470488606091 GO:0031490 chromatin DNA binding 10/1065 128/18639 0.078125 1.36729753521127 0.196466926465036 0.505878607757799 GO:0005385 zinc ion transmembrane transporter activity 3/1065 27/18639 0.111111111111111 1.94460093896714 0.198290423676298 0.509343594310683 GO:0035591 signaling adaptor activity 10/1065 129/18639 0.0775193798449612 1.35669832951196 0.202912732112946 0.519963876039423 GO:0001727 lipid kinase activity 4/1065 41/18639 0.0975609756097561 1.70745448299553 0.205107569855528 0.521824986792346 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1065 41/18639 0.0975609756097561 1.70745448299553 0.205107569855528 0.521824986792346 GO:0042287 MHC protein binding 4/1065 41/18639 0.0975609756097561 1.70745448299553 0.205107569855528 0.521824986792346 GO:0004559 alpha-mannosidase activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0004953 icosanoid receptor activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0005523 tropomyosin binding 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0031005 filamin binding 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0031386 protein tag activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0033130 acetylcholine receptor binding 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0048531 beta-1,3-galactosyltransferase activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0141047 molecular tag activity 2/1065 15/18639 0.133333333333333 2.33352112676056 0.210148106198376 0.522186203280812 GO:0051119 sugar transmembrane transporter activity 3/1065 28/18639 0.107142857142857 1.8751509054326 0.213337732716576 0.528879123432255 GO:0042379 chemokine receptor binding 6/1065 72/18639 0.0833333333333333 1.45845070422535 0.228331392469723 0.558670987915886 GO:0003785 actin monomer binding 3/1065 29/18639 0.103448275862069 1.8104905293832 0.228617832446138 0.558670987915886 GO:0016417 S-acyltransferase activity 3/1065 29/18639 0.103448275862069 1.8104905293832 0.228617832446138 0.558670987915886 GO:0035250 UDP-galactosyltransferase activity 3/1065 29/18639 0.103448275862069 1.8104905293832 0.228617832446138 0.558670987915886 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1065 29/18639 0.103448275862069 1.8104905293832 0.228617832446138 0.558670987915886 GO:0000062 fatty-acyl-CoA binding 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0008142 oxysterol binding 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0015378 sodium:chloride symporter activity 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0015923 mannosidase activity 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0022858 alanine transmembrane transporter activity 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1065 16/18639 0.125 2.18767605633803 0.231644068160245 0.558670987915886 GO:0019842 vitamin binding 11/1065 150/18639 0.0733333333333333 1.28343661971831 0.239018248579328 0.575154521412109 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1065 30/18639 0.1 1.75014084507042 0.244093225029928 0.586043643878161 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0008429 phosphatidylethanolamine binding 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0016018 cyclosporin A binding 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0016805 dipeptidase activity 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0030548 acetylcholine receptor regulator activity 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0031489 myosin V binding 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:1901567 fatty acid derivative binding 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:1990226 histone methyltransferase binding 2/1065 17/18639 0.117647058823529 2.05898922949461 0.253264306477763 0.595981789636414 GO:0001664 G protein-coupled receptor binding 20/1065 297/18639 0.0673400673400673 1.17854602361645 0.254932080840917 0.597506171526516 GO:0015108 chloride transmembrane transporter activity 9/1065 121/18639 0.0743801652892562 1.30175765335817 0.255033121993025 0.597506171526516 GO:0016922 nuclear receptor binding 10/1065 137/18639 0.072992700729927 1.27747506939447 0.257435721503025 0.601812454215405 GO:0003774 cytoskeletal motor activity 11/1065 153/18639 0.0718954248366013 1.25827119580226 0.258937259210975 0.603998070719691 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/1065 31/18639 0.0967741935483871 1.69368468877783 0.259727751737498 0.604519177624833 GO:0005543 phospholipid binding 32/1065 497/18639 0.0643863179074447 1.12685124833508 0.266003981121712 0.614369891186507 GO:0004180 carboxypeptidase activity 4/1065 46/18639 0.0869565217391304 1.52186160440906 0.267567011201924 0.614369891186507 GO:0030291 protein serine/threonine kinase inhibitor activity 4/1065 46/18639 0.0869565217391304 1.52186160440906 0.267567011201924 0.614369891186507 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/1065 61/18639 0.0819672131147541 1.43454167628723 0.268670924200011 0.614369891186507 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0003746 translation elongation factor activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0008409 5'-3' exonuclease activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0008525 phosphatidylcholine transporter activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0015373 monoatomic anion:sodium symporter activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0016854 racemase and epimerase activity 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0070064 proline-rich region binding 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0070628 proteasome binding 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:1901611 phosphatidylglycerol binding 2/1065 18/18639 0.111111111111111 1.94460093896714 0.274924526910901 0.614369891186507 GO:0008378 galactosyltransferase activity 3/1065 32/18639 0.09375 1.64075704225352 0.27548668666712 0.614369891186507 GO:0015106 bicarbonate transmembrane transporter activity 3/1065 32/18639 0.09375 1.64075704225352 0.27548668666712 0.614369891186507 GO:0043425 bHLH transcription factor binding 3/1065 32/18639 0.09375 1.64075704225352 0.27548668666712 0.614369891186507 GO:0051059 NF-kappaB binding 3/1065 32/18639 0.09375 1.64075704225352 0.27548668666712 0.614369891186507 GO:0070717 poly-purine tract binding 3/1065 32/18639 0.09375 1.64075704225352 0.27548668666712 0.614369891186507 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1065 33/18639 0.0909090909090909 1.5910371318822 0.291336808354096 0.647010495219722 GO:0071889 14-3-3 protein binding 3/1065 33/18639 0.0909090909090909 1.5910371318822 0.291336808354096 0.647010495219722 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1065 19/18639 0.105263157894737 1.84225352112676 0.296549645630658 0.65314446744273 GO:0016918 retinal binding 2/1065 19/18639 0.105263157894737 1.84225352112676 0.296549645630658 0.65314446744273 GO:0120227 acyl-CoA binding 2/1065 19/18639 0.105263157894737 1.84225352112676 0.296549645630658 0.65314446744273 GO:0140036 ubiquitin-modified protein reader activity 2/1065 19/18639 0.105263157894737 1.84225352112676 0.296549645630658 0.65314446744273 GO:0140996 histone H3 kinase activity 23/1065 357/18639 0.0644257703081232 1.12754172091372 0.305454773983214 0.670979912797387 GO:0001222 transcription corepressor binding 4/1065 49/18639 0.0816326530612245 1.42868640413912 0.306535851343647 0.670979912797387 GO:0016763 pentosyltransferase activity 4/1065 49/18639 0.0816326530612245 1.42868640413912 0.306535851343647 0.670979912797387 GO:0090482 vitamin transmembrane transporter activity 3/1065 34/18639 0.0882352941176471 1.54424192212096 0.307246451880323 0.671157208410706 GO:0001972 retinoic acid binding 2/1065 20/18639 0.1 1.75014084507042 0.318073013508367 0.689158195934794 GO:0005326 neurotransmitter transmembrane transporter activity 2/1065 20/18639 0.1 1.75014084507042 0.318073013508367 0.689158195934794 GO:0016505 peptidase activator activity involved in apoptotic process 2/1065 20/18639 0.1 1.75014084507042 0.318073013508367 0.689158195934794 GO:0031418 L-ascorbic acid binding 2/1065 20/18639 0.1 1.75014084507042 0.318073013508367 0.689158195934794 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1065 50/18639 0.08 1.40011267605634 0.319664497935667 0.68982744606855 GO:0035173 histone kinase activity 23/1065 360/18639 0.0638888888888889 1.1181455399061 0.319676133543962 0.68982744606855 GO:0043015 gamma-tubulin binding 3/1065 35/18639 0.0857142857142857 1.50012072434608 0.323185543853146 0.695991494439301 GO:0000287 magnesium ion binding 15/1065 230/18639 0.0652173913043478 1.1413962033068 0.336142771124447 0.715095760818854 GO:0004033 aldo-keto reductase (NADPH) activity 3/1065 36/18639 0.0833333333333333 1.45845070422535 0.339125622393693 0.715095760818854 GO:0055106 ubiquitin-protein transferase regulator activity 3/1065 36/18639 0.0833333333333333 1.45845070422535 0.339125622393693 0.715095760818854 GO:0001846 opsonin binding 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0005123 death receptor binding 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0008373 sialyltransferase activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0015125 bile acid transmembrane transporter activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0019200 carbohydrate kinase activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0061891 calcium ion sensor activity 2/1065 21/18639 0.0952380952380952 1.66680080482897 0.339435698850225 0.715095760818854 GO:0043130 ubiquitin binding 7/1065 100/18639 0.07 1.2250985915493 0.34627489808121 0.727259804646602 GO:0008509 monoatomic anion transmembrane transporter activity 10/1065 149/18639 0.0671140939597315 1.1745911711882 0.346574090769675 0.727259804646602 GO:0022829 wide pore channel activity 3/1065 37/18639 0.0810810810810811 1.41903311762467 0.355039844066462 0.743560852209918 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1065 53/18639 0.0754716981132075 1.32086101514749 0.359230251131938 0.749287502638031 GO:0033691 sialic acid binding 2/1065 22/18639 0.0909090909090909 1.5910371318822 0.360585824440253 0.749287502638031 GO:0140035 ubiquitin-like protein reader activity 2/1065 22/18639 0.0909090909090909 1.5910371318822 0.360585824440253 0.749287502638031 GO:0140517 protein-RNA adaptor activity 2/1065 22/18639 0.0909090909090909 1.5910371318822 0.360585824440253 0.749287502638031 GO:0015297 antiporter activity 9/1065 135/18639 0.0666666666666667 1.16676056338028 0.366145771492406 0.759360685624329 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/1065 86/18639 0.0697674418604651 1.22102849656076 0.368371249981638 0.762492723262964 GO:0042887 amide transmembrane transporter activity 3/1065 38/18639 0.0789473684210526 1.38169014084507 0.370902979491522 0.765920847116478 GO:0050661 NADP binding 4/1065 54/18639 0.0740740740740741 1.29640062597809 0.372425908611287 0.765920847116478 GO:0051287 NAD binding 4/1065 54/18639 0.0740740740740741 1.29640062597809 0.372425908611287 0.765920847116478 GO:0141003 histone H2AX kinase activity 22/1065 354/18639 0.0621468926553672 1.08765815230365 0.37290142556609 0.765920847116478 GO:0140789 histone phosphatase activity 9/1065 136/18639 0.0661764705882353 1.15818144159072 0.374351113323321 0.767419782312807 GO:0001216 DNA-binding transcription activator activity 30/1065 491/18639 0.0610997963340122 1.06933249189639 0.378293712583595 0.774013623059717 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1065 23/18639 0.0869565217391304 1.52186160440906 0.381477955036103 0.774581904892353 GO:0008171 O-methyltransferase activity 2/1065 23/18639 0.0869565217391304 1.52186160440906 0.381477955036103 0.774581904892353 GO:0016849 phosphorus-oxygen lyase activity 2/1065 23/18639 0.0869565217391304 1.52186160440906 0.381477955036103 0.774581904892353 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/1065 23/18639 0.0869565217391304 1.52186160440906 0.381477955036103 0.774581904892353 GO:0003714 transcription corepressor activity 13/1065 204/18639 0.0637254901960784 1.11528583264292 0.383319182513566 0.776840776729015 GO:0003712 transcription coregulator activity 30/1065 495/18639 0.0606060606060606 1.0606914212548 0.395674145001762 0.800039301674989 GO:0140030 modification-dependent protein binding 11/1065 173/18639 0.0635838150289017 1.11280631767484 0.401995126770219 0.800039301674989 GO:0005540 hyaluronic acid binding 2/1065 24/18639 0.0833333333333333 1.45845070422535 0.40207253172484 0.800039301674989 GO:0015149 hexose transmembrane transporter activity 2/1065 24/18639 0.0833333333333333 1.45845070422535 0.40207253172484 0.800039301674989 GO:0015295 solute:proton symporter activity 2/1065 24/18639 0.0833333333333333 1.45845070422535 0.40207253172484 0.800039301674989 GO:0055056 D-glucose transmembrane transporter activity 2/1065 24/18639 0.0833333333333333 1.45845070422535 0.40207253172484 0.800039301674989 GO:0070300 phosphatidic acid binding 2/1065 24/18639 0.0833333333333333 1.45845070422535 0.40207253172484 0.800039301674989 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/1065 40/18639 0.075 1.31260563380282 0.402383051188055 0.800039301674989 GO:0071949 FAD binding 3/1065 40/18639 0.075 1.31260563380282 0.402383051188055 0.800039301674989 GO:0000149 SNARE binding 7/1065 106/18639 0.0660377358490566 1.15575338825405 0.403021674483555 0.800039301674989 GO:0008013 beta-catenin binding 7/1065 106/18639 0.0660377358490566 1.15575338825405 0.403021674483555 0.800039301674989 GO:0004721 phosphoprotein phosphatase activity 11/1065 175/18639 0.0628571428571429 1.10008853118712 0.416784323275985 0.801315601554685 GO:0001530 lipopolysaccharide binding 3/1065 41/18639 0.0731707317073171 1.28059086224665 0.417957431293255 0.801315601554685 GO:0042169 SH2 domain binding 3/1065 41/18639 0.0731707317073171 1.28059086224665 0.417957431293255 0.801315601554685 GO:0001217 DNA-binding transcription repressor activity 17/1065 278/18639 0.0611510791366906 1.07023001317256 0.422067472834539 0.801315601554685 GO:0001848 complement binding 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0003707 nuclear steroid receptor activity 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0005537 D-mannose binding 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0008483 transaminase activity 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0019707 protein-cysteine S-acyltransferase activity 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0047617 fatty acyl-CoA hydrolase activity 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1065 25/18639 0.08 1.40011267605634 0.422335349791097 0.801315601554685 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 29/1065 484/18639 0.0599173553719008 1.04863810964963 0.422835713806159 0.801315601554685 GO:0044183 protein folding chaperone 5/1065 75/18639 0.0666666666666667 1.16676056338028 0.428419631406371 0.801315601554685 GO:0031492 nucleosomal DNA binding 3/1065 42/18639 0.0714285714285714 1.25010060362173 0.433395547758102 0.801315601554685 GO:0070888 E-box binding 4/1065 59/18639 0.0677966101694915 1.18653616614944 0.437811058812797 0.801315601554685 GO:0016289 acyl-CoA hydrolase activity 2/1065 26/18639 0.0769230769230769 1.34626218851571 0.442237076979014 0.801315601554685 GO:0030507 spectrin binding 2/1065 26/18639 0.0769230769230769 1.34626218851571 0.442237076979014 0.801315601554685 GO:0050681 nuclear androgen receptor binding 2/1065 26/18639 0.0769230769230769 1.34626218851571 0.442237076979014 0.801315601554685 GO:0052742 phosphatidylinositol kinase activity 2/1065 26/18639 0.0769230769230769 1.34626218851571 0.442237076979014 0.801315601554685 GO:0097602 cullin family protein binding 2/1065 26/18639 0.0769230769230769 1.34626218851571 0.442237076979014 0.801315601554685 GO:0001094 TFIID-class transcription factor complex binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0003796 lysozyme activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0004090 carbonyl reductase (NADPH) activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005031 tumor necrosis factor receptor activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005131 growth hormone receptor binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005337 nucleoside transmembrane transporter activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005345 purine nucleobase transmembrane transporter activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005522 profilin binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0005528 FK506 binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0008140 cAMP response element binding protein binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0016783 sulfurtransferase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0016868 intramolecular phosphotransferase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0031434 mitogen-activated protein kinase kinase binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0031996 thioesterase binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0032052 bile acid binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0035256 G protein-coupled glutamate receptor binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0042975 peroxisome proliferator activated receptor binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0043121 neurotrophin binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0043422 protein kinase B binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0099122 RNA polymerase II C-terminal domain binding 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0140999 histone H3K4 trimethyltransferase activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0141109 transporter activator activity 1/1065 10/18639 0.1 1.75014084507042 0.444842036201866 0.801315601554685 GO:0008200 ion channel inhibitor activity 3/1065 43/18639 0.0697674418604651 1.22102849656076 0.448679880759213 0.801315601554685 GO:1902936 phosphatidylinositol bisphosphate binding 7/1065 111/18639 0.0630630630630631 1.10369242481919 0.450234014170979 0.801315601554685 GO:0003724 RNA helicase activity 5/1065 77/18639 0.0649350649350649 1.13645509420157 0.451123750752673 0.801315601554685 GO:0035091 phosphatidylinositol binding 17/1065 284/18639 0.0598591549295775 1.04761951993652 0.457350157588248 0.801315601554685 GO:0043022 ribosome binding 7/1065 112/18639 0.0625 1.09383802816901 0.459605302766168 0.801315601554685 GO:0001671 ATPase activator activity 2/1065 27/18639 0.0740740740740741 1.29640062597809 0.461752809243232 0.801315601554685 GO:0008266 poly(U) RNA binding 2/1065 27/18639 0.0740740740740741 1.29640062597809 0.461752809243232 0.801315601554685 GO:0015081 sodium ion transmembrane transporter activity 10/1065 164/18639 0.0609756097560976 1.06715905187221 0.462905569086535 0.801315601554685 GO:0016836 hydro-lyase activity 4/1065 61/18639 0.0655737704918033 1.14763334102979 0.463452456911952 0.801315601554685 GO:0016248 channel inhibitor activity 3/1065 44/18639 0.0681818181818182 1.19327784891165 0.463794337944056 0.801315601554685 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/1065 44/18639 0.0681818181818182 1.19327784891165 0.463794337944056 0.801315601554685 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 16/1065 268/18639 0.0597014925373134 1.04486020601219 0.465063110992261 0.801315601554685 GO:0015103 inorganic anion transmembrane transporter activity 10/1065 165/18639 0.0606060606060606 1.0606914212548 0.470623298558066 0.801315601554685 GO:0016407 acetyltransferase activity 6/1065 96/18639 0.0625 1.09383802816901 0.471189747740618 0.801315601554685 GO:0016829 lyase activity 12/1065 200/18639 0.06 1.05008450704225 0.473368902928738 0.801315601554685 GO:0008186 ATP-dependent activity, acting on RNA 5/1065 79/18639 0.0632911392405063 1.1076840791585 0.473581756222516 0.801315601554685 GO:0016835 carbon-oxygen lyase activity 5/1065 79/18639 0.0632911392405063 1.1076840791585 0.473581756222516 0.801315601554685 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0003953 NAD+ nucleosidase activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0004016 adenylate cyclase activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0008046 axon guidance receptor activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0008432 JUN kinase binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0008503 benzodiazepine receptor activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0008526 phosphatidylinositol transfer activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0015205 nucleobase transmembrane transporter activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0019107 myristoyltransferase activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0032794 GTPase activating protein binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0043522 leucine zipper domain binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0047676 arachidonate-CoA ligase activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0048407 platelet-derived growth factor binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0050786 RAGE receptor binding 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1065 11/18639 0.0909090909090909 1.5910371318822 0.476579823063481 0.801315601554685 GO:0046915 transition metal ion transmembrane transporter activity 3/1065 45/18639 0.0666666666666667 1.16676056338028 0.478724206731316 0.802188624301207 GO:0141110 transporter inhibitor activity 3/1065 45/18639 0.0666666666666667 1.16676056338028 0.478724206731316 0.802188624301207 GO:0005242 inward rectifier potassium channel activity 2/1065 28/18639 0.0714285714285714 1.25010060362173 0.480861661283744 0.802188624301207 GO:0046966 nuclear thyroid hormone receptor binding 2/1065 28/18639 0.0714285714285714 1.25010060362173 0.480861661283744 0.802188624301207 GO:0051393 alpha-actinin binding 2/1065 28/18639 0.0714285714285714 1.25010060362173 0.480861661283744 0.802188624301207 GO:1901682 sulfur compound transmembrane transporter activity 4/1065 63/18639 0.0634920634920635 1.11120053655265 0.488668368192705 0.813938250770974 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/1065 46/18639 0.0652173913043478 1.1413962033068 0.493456104093831 0.814380268225822 GO:0003713 transcription coactivator activity 15/1065 256/18639 0.05859375 1.02547315140845 0.498109745543066 0.814380268225822 GO:0099604 ligand-gated calcium channel activity 2/1065 29/18639 0.0689655172413793 1.20699368625546 0.499546389345789 0.814380268225822 GO:0003995 acyl-CoA dehydrogenase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0004032 aldose reductase (NADPH) activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0004126 cytidine deaminase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0005095 GTPase inhibitor activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0005165 neurotrophin receptor binding 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0005247 voltage-gated chloride channel activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0005527 macrolide binding 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0010853 cyclase activator activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0016273 arginine N-methyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0016274 protein-arginine N-methyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0031543 peptidyl-proline dioxygenase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0042301 phosphate ion binding 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1065 12/18639 0.0833333333333333 1.45845070422535 0.506504800969719 0.814380268225822 GO:0120013 lipid transfer activity 4/1065 65/18639 0.0615384615384615 1.07700975081257 0.513384271431644 0.824198242991164 GO:0005254 chloride channel activity 5/1065 83/18639 0.0602409638554217 1.05430171389784 0.517528444712093 0.827537308605404 GO:0008187 poly-pyrimidine tract binding 2/1065 30/18639 0.0666666666666667 1.16676056338028 0.517793043939779 0.827537308605404 GO:0048019 receptor antagonist activity 2/1065 30/18639 0.0666666666666667 1.16676056338028 0.517793043939779 0.827537308605404 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/1065 48/18639 0.0625 1.09383802816901 0.522278786250834 0.833456865484116 GO:0032182 ubiquitin-like protein binding 7/1065 120/18639 0.0583333333333333 1.02091549295775 0.532951226887685 0.839571233749253 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0005035 death receptor activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0019855 calcium channel inhibitor activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0030955 potassium ion binding 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0035325 Toll-like receptor binding 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0061459 L-arginine transmembrane transporter activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1065 13/18639 0.0769230769230769 1.34626218851571 0.53472042275354 0.839571233749253 GO:0005164 tumor necrosis factor receptor binding 2/1065 31/18639 0.0645161290322581 1.12912312585189 0.535590650298557 0.839571233749253 GO:0016411 acylglycerol O-acyltransferase activity 2/1065 31/18639 0.0645161290322581 1.12912312585189 0.535590650298557 0.839571233749253 GO:0035254 glutamate receptor binding 3/1065 49/18639 0.0612244897959184 1.07151480310434 0.536348977657825 0.839571233749253 GO:0060590 ATPase regulator activity 3/1065 49/18639 0.0612244897959184 1.07151480310434 0.536348977657825 0.839571233749253 GO:0051082 unfolded protein binding 7/1065 121/18639 0.0578512396694215 1.01247817483413 0.541855757324246 0.846947562034671 GO:0030145 manganese ion binding 4/1065 68/18639 0.0588235294117647 1.02949461474731 0.549381450157772 0.848754103101305 GO:1990841 promoter-specific chromatin binding 4/1065 68/18639 0.0588235294117647 1.02949461474731 0.549381450157772 0.848754103101305 GO:0015605 organophosphate ester transmembrane transporter activity 3/1065 50/18639 0.06 1.05008450704225 0.550179901895409 0.848754103101305 GO:0031369 translation initiation factor binding 2/1065 32/18639 0.0625 1.09383802816901 0.552930914540652 0.848754103101305 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1065 32/18639 0.0625 1.09383802816901 0.552930914540652 0.848754103101305 GO:0004065 arylsulfatase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0004705 JUN kinase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0005545 1-phosphatidylinositol binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0015926 glucosidase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0016530 metallochaperone activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0019992 diacylglycerol binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0034236 protein kinase A catalytic subunit binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0042043 neurexin family protein binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0043176 amine binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0046030 inositol trisphosphate phosphatase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0061783 peptidoglycan muralytic activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0098599 palmitoyl hydrolase activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:1901474 azole transmembrane transporter activity 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:1901612 cardiolipin binding 1/1065 14/18639 0.0714285714285714 1.25010060362173 0.561324242670187 0.848754103101305 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1065 52/18639 0.0576923076923077 1.00969664138678 0.577094808847165 0.864607464837862 GO:0030159 signaling receptor complex adaptor activity 3/1065 52/18639 0.0576923076923077 1.00969664138678 0.577094808847165 0.864607464837862 GO:0003727 single-stranded RNA binding 5/1065 89/18639 0.0561797752808989 0.983225193859788 0.580303862457234 0.864607464837862 GO:0000774 adenyl-nucleotide exchange factor activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0004089 carbonate dehydratase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0008020 G protein-coupled photoreceptor activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0008242 omega peptidase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0015116 sulfate transmembrane transporter activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0015250 water channel activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0016846 carbon-sulfur lyase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0017081 chloride channel regulator activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0034483 heparan sulfate sulfotransferase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0042809 nuclear vitamin D receptor binding 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0045504 dynein heavy chain binding 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0047372 monoacylglycerol lipase activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0140161 monocarboxylate:sodium symporter activity 1/1065 15/18639 0.0666666666666667 1.16676056338028 0.586408252418174 0.864607464837862 GO:0005246 calcium channel regulator activity 3/1065 53/18639 0.0566037735849057 0.990645761360617 0.590166682310078 0.867748528748336 GO:0140296 general transcription initiation factor binding 3/1065 53/18639 0.0566037735849057 0.990645761360617 0.590166682310078 0.867748528748336 GO:0004674 protein serine/threonine kinase activity 24/1065 433/18639 0.0554272517321016 0.970054971863514 0.59174842505118 0.868875786645396 GO:0042826 histone deacetylase binding 7/1065 127/18639 0.0551181102362205 0.964644560275036 0.59369093540907 0.870528936927192 GO:0016791 phosphatase activity 15/1065 273/18639 0.0549450549450549 0.961615848939793 0.60000346330059 0.872916919604972 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 7/1065 128/18639 0.0546875 0.957108274647887 0.602038336648195 0.872916919604972 GO:0016229 steroid dehydrogenase activity 2/1065 35/18639 0.0571428571428571 1.00008048289738 0.602159411368027 0.872916919604972 GO:0140566 histone reader activity 2/1065 35/18639 0.0571428571428571 1.00008048289738 0.602159411368027 0.872916919604972 GO:0003925 G protein activity 3/1065 54/18639 0.0555555555555556 0.972300469483568 0.602974963115889 0.872916919604972 GO:0140463 chromatin-protein adaptor activity 3/1065 54/18639 0.0555555555555556 0.972300469483568 0.602974963115889 0.872916919604972 GO:0043539 protein serine/threonine kinase activator activity 4/1065 73/18639 0.0547945205479452 0.958981284970094 0.606089361953215 0.872916919604972 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0004707 MAP kinase activity 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0005149 interleukin-1 receptor binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0005159 insulin-like growth factor receptor binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0005521 lamin binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0015562 efflux transmembrane transporter activity 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0019841 retinol binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0030275 LRR domain binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0043023 ribosomal large subunit binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0070411 I-SMAD binding 1/1065 16/18639 0.0625 1.09383802816901 0.61005919803537 0.872916919604972 GO:0008374 O-acyltransferase activity 3/1065 55/18639 0.0545454545454545 0.954622279129321 0.615515818278502 0.876692008448188 GO:0035064 methylated histone binding 4/1065 74/18639 0.0540540540540541 0.946022078416445 0.616894738854804 0.876692008448188 GO:1901981 phosphatidylinositol phosphate binding 10/1065 185/18639 0.0540540540540541 0.946022078416445 0.617449511618093 0.876692008448188 GO:0004190 aspartic-type endopeptidase activity 2/1065 36/18639 0.0555555555555556 0.972300469483568 0.617631987190046 0.876692008448188 GO:0005484 SNAP receptor activity 2/1065 36/18639 0.0555555555555556 0.972300469483568 0.617631987190046 0.876692008448188 GO:0016409 palmitoyltransferase activity 2/1065 36/18639 0.0555555555555556 0.972300469483568 0.617631987190046 0.876692008448188 GO:0003725 double-stranded RNA binding 4/1065 75/18639 0.0533333333333333 0.933408450704225 0.627513054767391 0.880406411458415 GO:0019003 GDP binding 4/1065 75/18639 0.0533333333333333 0.933408450704225 0.627513054767391 0.880406411458415 GO:0030170 pyridoxal phosphate binding 3/1065 56/18639 0.0535714285714286 0.937575452716298 0.627786210672001 0.880406411458415 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0008484 sulfuric ester hydrolase activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0009881 photoreceptor activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0015278 intracellularly gated calcium channel activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0032977 membrane insertase activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0036041 long-chain fatty acid binding 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0045125 bioactive lipid receptor activity 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0051787 misfolded protein binding 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0070403 NAD+ binding 1/1065 17/18639 0.0588235294117647 1.02949461474731 0.63235887875772 0.880406411458415 GO:0042805 actinin binding 2/1065 37/18639 0.0540540540540541 0.946022078416445 0.632637252511394 0.880406411458415 GO:0070001 aspartic-type peptidase activity 2/1065 37/18639 0.0540540540540541 0.946022078416445 0.632637252511394 0.880406411458415 GO:0140034 methylation-dependent protein binding 4/1065 76/18639 0.0526315789473684 0.92112676056338 0.637941638732437 0.886630752136608 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1065 57/18639 0.0526315789473684 0.92112676056338 0.639783849420961 0.886878522084194 GO:0070279 vitamin B6 binding 3/1065 57/18639 0.0526315789473684 0.92112676056338 0.639783849420961 0.886878522084194 GO:0042162 telomeric DNA binding 2/1065 38/18639 0.0526315789473684 0.92112676056338 0.647178045456943 0.895963372022209 GO:0051087 protein-folding chaperone binding 7/1065 134/18639 0.0522388059701493 0.914252680260668 0.650161109276993 0.896406436514203 GO:0000400 four-way junction DNA binding 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0005372 water transmembrane transporter activity 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0008308 voltage-gated monoatomic anion channel activity 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0017128 phospholipid scramblase activity 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0050811 GABA receptor binding 1/1065 18/18639 0.0555555555555556 0.972300469483568 0.653384428866356 0.896406436514203 GO:0000217 DNA secondary structure binding 2/1065 39/18639 0.0512820512820513 0.89750812567714 0.661258404713714 0.902667163437226 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1065 39/18639 0.0512820512820513 0.89750812567714 0.661258404713714 0.902667163437226 GO:0046332 SMAD binding 4/1065 79/18639 0.0506329113924051 0.886147263326796 0.668068411846499 0.902667163437226 GO:0003756 protein disulfide isomerase activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0008301 DNA binding, bending 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0008574 plus-end-directed microtubule motor activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0031420 alkali metal ion binding 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0042577 lipid phosphatase activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0042800 histone H3K4 methyltransferase activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0042834 peptidoglycan binding 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0043395 heparan sulfate proteoglycan binding 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0046527 glucosyltransferase activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0046624 sphingolipid transporter activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:1990380 K48-linked deubiquitinase activity 1/1065 19/18639 0.0526315789473684 0.92112676056338 0.673208583490562 0.902667163437226 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/1065 60/18639 0.05 0.875070422535211 0.674127527673279 0.902667163437226 GO:0030331 nuclear estrogen receptor binding 2/1065 40/18639 0.05 0.875070422535211 0.674883423320328 0.902667163437226 GO:0050997 quaternary ammonium group binding 2/1065 40/18639 0.05 0.875070422535211 0.674883423320328 0.902667163437226 GO:0071855 neuropeptide receptor binding 2/1065 40/18639 0.05 0.875070422535211 0.674883423320328 0.902667163437226 GO:0000049 tRNA binding 4/1065 80/18639 0.05 0.875070422535211 0.677719392979564 0.905324402150645 GO:0001614 purinergic nucleotide receptor activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0010851 cyclase regulator activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0015464 acetylcholine receptor activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0016502 nucleotide receptor activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0052745 inositol phosphate phosphatase activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0140939 histone H4 methyltransferase activity 1/1065 20/18639 0.05 0.875070422535211 0.691899929279098 0.915093454853001 GO:0004520 DNA endonuclease activity 2/1065 42/18639 0.0476190476190476 0.833400402414487 0.700792293592205 0.922277265394186 GO:0019894 kinesin binding 2/1065 42/18639 0.0476190476190476 0.833400402414487 0.700792293592205 0.922277265394186 GO:0035198 miRNA binding 2/1065 42/18639 0.0476190476190476 0.833400402414487 0.700792293592205 0.922277265394186 GO:0043175 RNA polymerase core enzyme binding 2/1065 42/18639 0.0476190476190476 0.833400402414487 0.700792293592205 0.922277265394186 GO:0005253 monoatomic anion channel activity 5/1065 103/18639 0.0485436893203883 0.849582934500205 0.707719842728628 0.926901554036003 GO:0020037 heme binding 7/1065 142/18639 0.0492957746478873 0.862745487006546 0.708650024879489 0.926901554036003 GO:0009975 cyclase activity 1/1065 21/18639 0.0476190476190476 0.833400402414487 0.709523140800542 0.926901554036003 GO:0015174 basic amino acid transmembrane transporter activity 1/1065 21/18639 0.0476190476190476 0.833400402414487 0.709523140800542 0.926901554036003 GO:0035613 RNA stem-loop binding 1/1065 21/18639 0.0476190476190476 0.833400402414487 0.709523140800542 0.926901554036003 GO:0072542 protein phosphatase activator activity 1/1065 21/18639 0.0476190476190476 0.833400402414487 0.709523140800542 0.926901554036003 GO:0004527 exonuclease activity 4/1065 84/18639 0.0476190476190476 0.833400402414487 0.714348101950069 0.93206251735468 GO:0004536 DNA nuclease activity 3/1065 64/18639 0.046875 0.820378521126761 0.716072959921089 0.933170874420393 GO:0005243 gap junction channel activity 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0008649 rRNA methyltransferase activity 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0034062 5'-3' RNA polymerase activity 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0061133 endopeptidase activator activity 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0097747 RNA polymerase activity 1/1065 22/18639 0.0454545454545455 0.795518565941101 0.726139203484366 0.93825986777495 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/1065 45/18639 0.0444444444444444 0.777840375586854 0.736414610831613 0.950384957804479 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0005158 insulin receptor binding 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0005212 structural constituent of eye lens 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0043274 phospholipase binding 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0099186 structural constituent of postsynapse 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0140102 catalytic activity, acting on a rRNA 1/1065 23/18639 0.0434782608695652 0.760930802204531 0.741805623868377 0.950438455581359 GO:0042054 histone methyltransferase activity 3/1065 67/18639 0.0447761194029851 0.783645154509144 0.744696658962126 0.952997165010355 GO:0140597 protein carrier chaperone 9/1065 188/18639 0.0478723404255319 0.837833383278394 0.753282863874881 0.953426995925805 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0004806 triacylglycerol lipase activity 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0005315 phosphate transmembrane transporter activity 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0070840 dynein complex binding 1/1065 24/18639 0.0416666666666667 0.729225352112676 0.756576627874618 0.953426995925805 GO:0140359 ABC-type transporter activity 2/1065 47/18639 0.0425531914893617 0.74474078513635 0.758101746202594 0.953426995925805 GO:0140938 histone H3 methyltransferase activity 2/1065 47/18639 0.0425531914893617 0.74474078513635 0.758101746202594 0.953426995925805 GO:0042393 histone binding 12/1065 247/18639 0.048582995951417 0.850270855904659 0.758638498822952 0.953426995925805 GO:0008080 N-acetyltransferase activity 3/1065 69/18639 0.0434782608695652 0.760930802204531 0.762467796546876 0.953426995925805 GO:0016279 protein-lysine N-methyltransferase activity 3/1065 69/18639 0.0434782608695652 0.760930802204531 0.762467796546876 0.953426995925805 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 11/1065 229/18639 0.0480349344978166 0.840679008549111 0.764757514788006 0.953426995925805 GO:0031072 heat shock protein binding 6/1065 131/18639 0.0458015267175573 0.801591226749812 0.765906785108613 0.953426995925805 GO:0038187 pattern recognition receptor activity 2/1065 48/18639 0.0416666666666667 0.729225352112676 0.768354918374409 0.953426995925805 GO:0140693 molecular condensate scaffold activity 2/1065 48/18639 0.0416666666666667 0.729225352112676 0.768354918374409 0.953426995925805 GO:0000030 mannosyltransferase activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0004709 MAP kinase kinase kinase activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0015645 fatty acid ligase activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0015662 P-type ion transporter activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0017025 TBP-class protein binding 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0019211 phosphatase activator activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0120515 fatty acid-CoA ligase activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0140358 P-type transmembrane transporter activity 1/1065 25/18639 0.04 0.700056338028169 0.770503347794765 0.953426995925805 GO:0016278 lysine N-methyltransferase activity 3/1065 70/18639 0.0428571428571429 0.750060362173038 0.770970047362143 0.953426995925805 GO:0046906 tetrapyrrole binding 7/1065 152/18639 0.0460526315789474 0.805985915492958 0.772052529777922 0.953659324152104 GO:0140299 molecular sensor activity 3/1065 71/18639 0.0422535211267606 0.739496131719897 0.779221801037308 0.959074446081289 GO:0005506 iron ion binding 7/1065 154/18639 0.0454545454545455 0.795518565941101 0.783428132956029 0.959074446081289 GO:0004529 DNA exonuclease activity 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0005112 Notch binding 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0008157 protein phosphatase 1 binding 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0051139 metal cation:proton antiporter activity 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0070412 R-SMAD binding 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0120014 phospholipid transfer activity 1/1065 26/18639 0.0384615384615385 0.673131094257855 0.783633998627395 0.959074446081289 GO:0051213 dioxygenase activity 4/1065 93/18639 0.043010752688172 0.752748750567924 0.785344559150679 0.960065711071816 GO:0046982 protein heterodimerization activity 18/1065 369/18639 0.0487804878048781 0.853727241497767 0.788512258497745 0.962833983457728 GO:0016410 N-acyltransferase activity 4/1065 94/18639 0.0425531914893617 0.74474078513635 0.792288656423079 0.963111593488021 GO:0004521 RNA endonuclease activity 3/1065 73/18639 0.0410958904109589 0.719235963727571 0.794990141195118 0.963111593488021 GO:0008395 steroid hydroxylase activity 1/1065 27/18639 0.037037037037037 0.648200312989045 0.79601404437294 0.963111593488021 GO:0016405 CoA-ligase activity 1/1065 27/18639 0.037037037037037 0.648200312989045 0.79601404437294 0.963111593488021 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1065 27/18639 0.037037037037037 0.648200312989045 0.79601404437294 0.963111593488021 GO:0035255 ionotropic glutamate receptor binding 1/1065 27/18639 0.037037037037037 0.648200312989045 0.79601404437294 0.963111593488021 GO:0016597 amino acid binding 2/1065 51/18639 0.0392156862745098 0.686329743164871 0.796870943204911 0.963111593488021 GO:0016830 carbon-carbon lyase activity 2/1065 51/18639 0.0392156862745098 0.686329743164871 0.796870943204911 0.963111593488021 GO:0030544 Hsp70 protein binding 2/1065 51/18639 0.0392156862745098 0.686329743164871 0.796870943204911 0.963111593488021 GO:0008276 protein methyltransferase activity 4/1065 95/18639 0.0421052631578947 0.736901408450704 0.799051295617198 0.963563652379776 GO:0043021 ribonucleoprotein complex binding 8/1065 177/18639 0.0451977401129944 0.791024110766293 0.799052784900302 0.963563652379776 GO:0031491 nucleosome binding 3/1065 74/18639 0.0405405405405405 0.709516558812334 0.802515299040483 0.966322844307895 GO:0140658 ATP-dependent chromatin remodeler activity 7/1065 158/18639 0.0443037974683544 0.775378855410947 0.804899006043833 0.966322844307895 GO:0046873 metal ion transmembrane transporter activity 22/1065 450/18639 0.0488888888888889 0.85562441314554 0.804905147670243 0.966322844307895 GO:0016866 intramolecular transferase activity 1/1065 28/18639 0.0357142857142857 0.625050301810865 0.807686354857725 0.966322844307895 GO:0050698 proteoglycan sulfotransferase activity 1/1065 28/18639 0.0357142857142857 0.625050301810865 0.807686354857725 0.966322844307895 GO:0051019 mitogen-activated protein kinase binding 1/1065 28/18639 0.0357142857142857 0.625050301810865 0.807686354857725 0.966322844307895 GO:0051959 dynein light intermediate chain binding 1/1065 28/18639 0.0357142857142857 0.625050301810865 0.807686354857725 0.966322844307895 GO:0004864 protein phosphatase inhibitor activity 2/1065 53/18639 0.0377358490566038 0.660430507573744 0.814112784903501 0.972919538909341 GO:0005249 voltage-gated potassium channel activity 4/1065 98/18639 0.0408163265306122 0.71434320206956 0.818275340748078 0.974023418488086 GO:0008170 N-methyltransferase activity 4/1065 98/18639 0.0408163265306122 0.71434320206956 0.818275340748078 0.974023418488086 GO:0042626 ATPase-coupled transmembrane transporter activity 4/1065 98/18639 0.0408163265306122 0.71434320206956 0.818275340748078 0.974023418488086 GO:0004181 metallocarboxypeptidase activity 1/1065 29/18639 0.0344827586206897 0.603496843127732 0.818691353626008 0.974023418488086 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/1065 54/18639 0.037037037037037 0.648200312989045 0.82223347035687 0.977147022742947 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0031210 phosphatidylcholine binding 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0031624 ubiquitin conjugating enzyme binding 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0051721 protein phosphatase 2A binding 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0098918 structural constituent of synapse 1/1065 30/18639 0.0333333333333333 0.583380281690141 0.829067157408292 0.978721583385647 GO:0140713 histone chaperone activity 7/1065 164/18639 0.0426829268292683 0.747011336310546 0.833993983218248 0.981573862074503 GO:0019212 phosphatase inhibitor activity 2/1065 56/18639 0.0357142857142857 0.625050301810865 0.837524800391592 0.981573862074503 GO:0005452 solute:inorganic anion antiporter activity 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0008327 methyl-CpG binding 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0016878 acid-thiol ligase activity 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0017147 Wnt-protein binding 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0072349 modified amino acid transmembrane transporter activity 1/1065 31/18639 0.032258064516129 0.564561562925943 0.838849707645283 0.981573862074503 GO:0035402 histone H3T11 kinase activity 11/1065 247/18639 0.0445344129554656 0.779414951245937 0.841148146307998 0.983184127153866 GO:0042910 xenobiotic transmembrane transporter activity 1/1065 32/18639 0.03125 0.546919014084507 0.848072894519626 0.990192448584799 GO:0061980 regulatory RNA binding 2/1065 58/18639 0.0344827586206897 0.603496843127732 0.851615674666499 0.99317337507175 GO:0003924 GTPase activity 15/1065 331/18639 0.0453172205438066 0.793115186587805 0.855535459375052 0.99317337507175 GO:0019239 deaminase activity 1/1065 33/18639 0.0303030303030303 0.530345710627401 0.856768673921819 0.99317337507175 GO:0031593 polyubiquitin modification-dependent protein binding 2/1065 59/18639 0.0338983050847458 0.593268083074719 0.858235342333425 0.99317337507175 GO:0070063 RNA polymerase binding 2/1065 59/18639 0.0338983050847458 0.593268083074719 0.858235342333425 0.99317337507175 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/1065 83/18639 0.036144578313253 0.632581028338707 0.860305954032724 0.99317337507175 GO:0001098 basal transcription machinery binding 2/1065 60/18639 0.0333333333333333 0.583380281690141 0.864583887666533 0.99317337507175 GO:0001099 basal RNA polymerase II transcription machinery binding 2/1065 60/18639 0.0333333333333333 0.583380281690141 0.864583887666533 0.99317337507175 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/1065 60/18639 0.0333333333333333 0.583380281690141 0.864583887666533 0.99317337507175 GO:0015020 glucuronosyltransferase activity 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0016831 carboxy-lyase activity 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0030332 cyclin binding 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0051427 hormone receptor binding 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1065 34/18639 0.0294117647058824 0.514747307373654 0.864967177752479 0.99317337507175 GO:0000510 H3-H4 histone complex chaperone activity 6/1065 151/18639 0.0397350993377483 0.695420203339241 0.868327941432337 0.99317337507175 GO:0140584 chromatin extrusion motor activity 6/1065 151/18639 0.0397350993377483 0.695420203339241 0.868327941432337 0.99317337507175 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/1065 151/18639 0.0397350993377483 0.695420203339241 0.868327941432337 0.99317337507175 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/1065 151/18639 0.0397350993377483 0.695420203339241 0.868327941432337 0.99317337507175 GO:0008017 microtubule binding 12/1065 276/18639 0.0434782608695652 0.760930802204531 0.870447569143368 0.993904709320848 GO:0015616 DNA translocase activity 6/1065 152/18639 0.0394736842105263 0.690845070422535 0.872284465198957 0.993904709320848 GO:0140674 ATP-dependent histone chaperone activity 6/1065 152/18639 0.0394736842105263 0.690845070422535 0.872284465198957 0.993904709320848 GO:0061631 ubiquitin conjugating enzyme activity 1/1065 35/18639 0.0285714285714286 0.500040241448692 0.872696817940257 0.993904709320848 GO:0005525 GTP binding 17/1065 378/18639 0.044973544973545 0.787100380058126 0.875728871476486 0.995115209353409 GO:0061775 cohesin loader activity 6/1065 153/18639 0.0392156862745098 0.686329743164871 0.876141212125408 0.995115209353409 GO:0000993 RNA polymerase II complex binding 1/1065 36/18639 0.0277777777777778 0.486150234741784 0.87998438453312 0.995115209353409 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1065 36/18639 0.0277777777777778 0.486150234741784 0.87998438453312 0.995115209353409 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/1065 36/18639 0.0277777777777778 0.486150234741784 0.87998438453312 0.995115209353409 GO:0019001 guanyl nucleotide binding 18/1065 400/18639 0.045 0.78756338028169 0.881057186376956 0.995115209353409 GO:0032561 guanyl ribonucleotide binding 18/1065 400/18639 0.045 0.78756338028169 0.881057186376956 0.995115209353409 GO:0004386 helicase activity 6/1065 155/18639 0.0387096774193548 0.677473875511131 0.883562060495801 0.995115209353409 GO:0030280 structural constituent of skin epidermis 1/1065 37/18639 0.027027027027027 0.473011039208222 0.88685513820039 0.995115209353409 GO:0003730 mRNA 3'-UTR binding 11/1065 262/18639 0.0419847328244275 0.734791957853994 0.888851974116775 0.995115209353409 GO:0015631 tubulin binding 17/1065 385/18639 0.0441558441558442 0.77278946405707 0.892341119582102 0.995115209353409 GO:0160215 deacylase activity 2/1065 65/18639 0.0307692307692308 0.538504875406284 0.892580004668236 0.995115209353409 GO:0003689 DNA clamp loader activity 6/1065 160/18639 0.0375 0.656302816901408 0.900486033900619 0.995115209353409 GO:0004679 AMP-activated protein kinase activity 10/1065 248/18639 0.0403225806451613 0.705701953657428 0.906576298574133 0.995115209353409 GO:0003777 microtubule motor activity 2/1065 68/18639 0.0294117647058824 0.514747307373654 0.906692038054328 0.995115209353409 GO:0140104 molecular carrier activity 10/1065 249/18639 0.0401606425702811 0.70286780926523 0.909014451699129 0.995115209353409 GO:0008227 G protein-coupled amine receptor activity 1/1065 41/18639 0.024390243902439 0.426863620748884 0.910626456743617 0.995115209353409 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1065 41/18639 0.024390243902439 0.426863620748884 0.910626456743617 0.995115209353409 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/1065 41/18639 0.024390243902439 0.426863620748884 0.910626456743617 0.995115209353409 GO:0140828 metal cation:monoatomic cation antiporter activity 1/1065 41/18639 0.024390243902439 0.426863620748884 0.910626456743617 0.995115209353409 GO:0002039 p53 binding 2/1065 69/18639 0.0289855072463768 0.507287201469688 0.910997239293356 0.995115209353409 GO:0016782 transferase activity, transferring sulphur-containing groups 2/1065 70/18639 0.0285714285714286 0.500040241448692 0.915115686114862 0.995115209353409 GO:0004518 nuclease activity 8/1065 209/18639 0.0382775119617225 0.669910371318822 0.915513972402971 0.995115209353409 GO:0004402 histone acetyltransferase activity 1/1065 42/18639 0.0238095238095238 0.416700201207243 0.915744363161944 0.995115209353409 GO:0048487 beta-tubulin binding 1/1065 42/18639 0.0238095238095238 0.416700201207243 0.915744363161944 0.995115209353409 GO:0051879 Hsp90 protein binding 1/1065 42/18639 0.0238095238095238 0.416700201207243 0.915744363161944 0.995115209353409 GO:0048156 tau protein binding 1/1065 43/18639 0.0232558139534884 0.407009498853587 0.92056945609266 0.995115209353409 GO:0008528 G protein-coupled peptide receptor activity 4/1065 122/18639 0.0327868852459016 0.573816670514893 0.923420449779797 0.995115209353409 GO:0043014 alpha-tubulin binding 1/1065 44/18639 0.0227272727272727 0.397759282970551 0.925118473583589 0.995115209353409 GO:0106310 protein serine kinase activity 15/1065 361/18639 0.0415512465373961 0.727205337286879 0.925303843121169 0.995115209353409 GO:0015085 calcium ion transmembrane transporter activity 5/1065 147/18639 0.0340136054421769 0.595286001724634 0.927741726069268 0.995115209353409 GO:0005267 potassium channel activity 4/1065 124/18639 0.032258064516129 0.564561562925943 0.92903997374631 0.995115209353409 GO:0051539 4 iron, 4 sulfur cluster binding 1/1065 45/18639 0.0222222222222222 0.388920187793427 0.929407197737043 0.995115209353409 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1065 46/18639 0.0217391304347826 0.380465401102266 0.933450509257429 0.995115209353409 GO:0004519 endonuclease activity 4/1065 127/18639 0.031496062992126 0.551225463014306 0.936773000400277 0.995115209353409 GO:0061733 protein-lysine-acetyltransferase activity 1/1065 47/18639 0.0212765957446809 0.372370392568175 0.937262438889056 0.995115209353409 GO:0061749 forked DNA-dependent helicase activity 1/1065 47/18639 0.0212765957446809 0.372370392568175 0.937262438889056 0.995115209353409 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1065 47/18639 0.0212765957446809 0.372370392568175 0.937262438889056 0.995115209353409 GO:0004722 protein serine/threonine phosphatase activity 3/1065 103/18639 0.029126213592233 0.509749760700123 0.938560185486431 0.995115209353409 GO:0001653 peptide receptor activity 4/1065 128/18639 0.03125 0.546919014084507 0.939175505457324 0.995115209353409 GO:0051540 metal cluster binding 2/1065 77/18639 0.025974025974026 0.454582037680629 0.939298200393941 0.995115209353409 GO:0008188 neuropeptide receptor activity 1/1065 48/18639 0.0208333333333333 0.364612676056338 0.940856215921282 0.995115209353409 GO:0009378 four-way junction helicase activity 1/1065 48/18639 0.0208333333333333 0.364612676056338 0.940856215921282 0.995115209353409 GO:0036121 double-stranded DNA helicase activity 1/1065 48/18639 0.0208333333333333 0.364612676056338 0.940856215921282 0.995115209353409 GO:0043138 3'-5' DNA helicase activity 1/1065 48/18639 0.0208333333333333 0.364612676056338 0.940856215921282 0.995115209353409 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 9/1065 243/18639 0.037037037037037 0.648200312989045 0.940915851878008 0.995115209353409 GO:0004676 3-phosphoinositide-dependent protein kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0004711 ribosomal protein S6 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0035175 histone H3S10 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0035979 histone H2AXS139 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0044022 histone H3S28 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0044023 histone H4S1 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0044024 histone H2AS1 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0044025 histone H2BS14 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0072354 histone H3T3 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0072371 histone H2AS121 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0072518 Rho-dependent protein serine/threonine kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0140823 histone H2BS36 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0140855 histone H3S57 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0140995 histone H2A kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0140997 histone H4 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0140998 histone H2B kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:1990244 histone H2AT120 kinase activity 9/1065 245/18639 0.036734693877551 0.642908881862604 0.94429198220852 0.995115209353409 GO:0005262 calcium channel activity 4/1065 131/18639 0.0305343511450382 0.534394151166541 0.945892743384435 0.995115209353409 GO:0004677 DNA-dependent protein kinase activity 9/1065 246/18639 0.0365853658536585 0.640295431123325 0.945915640787197 0.995115209353409 GO:0140857 histone H3T45 kinase activity 9/1065 246/18639 0.0365853658536585 0.640295431123325 0.945915640787197 0.995115209353409 GO:0016887 ATP hydrolysis activity 17/1065 417/18639 0.0407673860911271 0.713486675448374 0.946969283173898 0.995115209353409 GO:0035403 histone H3T6 kinase activity 9/1065 247/18639 0.0364372469635627 0.637703141928494 0.947497523353848 0.995115209353409 GO:0019888 protein phosphatase regulator activity 3/1065 107/18639 0.0280373831775701 0.490693694879558 0.948239062149143 0.995115209353409 GO:0033192 calmodulin-dependent protein phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0140791 histone H2AXS140 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/1065 81/18639 0.0246913580246914 0.432133541992697 0.950015286472108 0.995115209353409 GO:0004843 cysteine-type deubiquitinase activity 3/1065 108/18639 0.0277777777777778 0.486150234741784 0.950426566717111 0.995115209353409 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/1065 181/18639 0.0331491712707182 0.58015718621119 0.95043288973591 0.995115209353409 GO:0005048 signal sequence binding 1/1065 51/18639 0.0196078431372549 0.343164871582436 0.950449844913248 0.995115209353409 GO:0005272 sodium channel activity 1/1065 51/18639 0.0196078431372549 0.343164871582436 0.950449844913248 0.995115209353409 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/1065 82/18639 0.024390243902439 0.426863620748884 0.952397915969698 0.995115209353409 GO:0033549 MAP kinase phosphatase activity 2/1065 82/18639 0.024390243902439 0.426863620748884 0.952397915969698 0.995115209353409 GO:0015079 potassium ion transmembrane transporter activity 5/1065 160/18639 0.03125 0.546919014084507 0.954864867026435 0.995115209353409 GO:0016779 nucleotidyltransferase activity 4/1065 136/18639 0.0294117647058824 0.514747307373654 0.955595945154717 0.995115209353409 GO:0099094 ligand-gated monoatomic cation channel activity 4/1065 136/18639 0.0294117647058824 0.514747307373654 0.955595945154717 0.995115209353409 GO:0008146 sulfotransferase activity 1/1065 53/18639 0.0188679245283019 0.330215253786872 0.955965284749674 0.995115209353409 GO:0034212 protein N-acetyltransferase activity 1/1065 53/18639 0.0188679245283019 0.330215253786872 0.955965284749674 0.995115209353409 GO:0017018 myosin phosphatase activity 2/1065 84/18639 0.0238095238095238 0.416700201207243 0.956841547455201 0.995115209353409 GO:0008094 ATP-dependent activity, acting on DNA 7/1065 210/18639 0.0333333333333333 0.583380281690141 0.959320216014651 0.996720614299823 GO:0101005 deubiquitinase activity 3/1065 115/18639 0.0260869565217391 0.456558481322719 0.963483749402054 0.998115737856334 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/1065 167/18639 0.029940119760479 0.523994264991145 0.96526896099143 0.998115737856334 GO:0016874 ligase activity 5/1065 167/18639 0.029940119760479 0.523994264991145 0.96526896099143 0.998115737856334 GO:0022843 voltage-gated monoatomic cation channel activity 4/1065 143/18639 0.027972027972028 0.489549886732985 0.966501657640826 0.998115737856334 GO:0019208 phosphatase regulator activity 3/1065 117/18639 0.0256410256410256 0.44875406283857 0.966573015039317 0.998115737856334 GO:0008408 3'-5' exonuclease activity 1/1065 58/18639 0.0172413793103448 0.301748421563866 0.967217220643145 0.998115737856334 GO:0017116 single-stranded DNA helicase activity 1/1065 58/18639 0.0172413793103448 0.301748421563866 0.967217220643145 0.998115737856334 GO:0061630 ubiquitin protein ligase activity 13/1065 353/18639 0.0368271954674221 0.644527789969277 0.96888262617664 0.998867388302029 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1065 60/18639 0.0166666666666667 0.29169014084507 0.970867613983656 0.99957058640954 GO:0004540 RNA nuclease activity 3/1065 121/18639 0.0247933884297521 0.433919217786055 0.972026527090001 0.99957058640954 GO:0005244 voltage-gated monoatomic ion channel activity 5/1065 173/18639 0.0289017341040462 0.505821053488561 0.972377765578511 0.99957058640954 GO:0022832 voltage-gated channel activity 5/1065 175/18639 0.0285714285714286 0.500040241448692 0.974430012908835 0.999971973786806 GO:0005216 monoatomic ion channel activity 17/1065 448/18639 0.0379464285714286 0.664115945674044 0.975237646535995 0.999971973786806 GO:0005261 monoatomic cation channel activity 12/1065 341/18639 0.0351906158357771 0.615885341373756 0.976610149327122 0.999971973786806 GO:0030594 neurotransmitter receptor activity 2/1065 97/18639 0.0206185567010309 0.360853782488747 0.977386198614763 0.999971973786806 GO:0019783 ubiquitin-like protein peptidase activity 3/1065 127/18639 0.0236220472440945 0.41341909726073 0.978651694954016 0.999971973786806 GO:0008173 RNA methyltransferase activity 1/1065 67/18639 0.0149253731343284 0.261215051503048 0.980729753363784 0.999971973786806 GO:0061659 ubiquitin-like protein ligase activity 13/1065 372/18639 0.0349462365591398 0.611608359836438 0.981852770303154 0.999971973786806 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1065 69/18639 0.0144927536231884 0.253643600734844 0.98287652263487 0.999971973786806 GO:0022834 ligand-gated channel activity 5/1065 188/18639 0.0265957446808511 0.465462990710219 0.984671275859372 0.999971973786806 GO:0045182 translation regulator activity 12/1065 356/18639 0.0337078651685393 0.589935116315873 0.985050725401063 0.999971973786806 GO:0016741 transferase activity, transferring one-carbon groups 6/1065 215/18639 0.027906976744186 0.488411398624304 0.985602441503436 0.999971973786806 GO:0004497 monooxygenase activity 2/1065 106/18639 0.0188679245283019 0.330215253786872 0.985662485880481 0.999971973786806 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1065 73/18639 0.0136986301369863 0.239745321242524 0.98647976403631 0.999971973786806 GO:0003678 DNA helicase activity 1/1065 74/18639 0.0135135135135135 0.236505519604111 0.987255324270142 0.999971973786806 GO:0003684 damaged DNA binding 1/1065 74/18639 0.0135135135135135 0.236505519604111 0.987255324270142 0.999971973786806 GO:0051536 iron-sulfur cluster binding 1/1065 76/18639 0.0131578947368421 0.230281690140845 0.988675642884262 0.999971973786806 GO:0008168 methyltransferase activity 5/1065 204/18639 0.0245098039215686 0.428956089478045 0.992007702502782 0.999971973786806 GO:0003697 single-stranded DNA binding 2/1065 121/18639 0.0165289256198347 0.289279478524037 0.993372978143315 0.999971973786806 GO:0140097 catalytic activity, acting on DNA 10/1065 336/18639 0.0297619047619048 0.520875251509054 0.993700114714469 0.999971973786806 GO:0015276 ligand-gated monoatomic ion channel activity 4/1065 186/18639 0.021505376344086 0.376374375283962 0.994678108075802 0.999971973786806 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/1065 130/18639 0.0153846153846154 0.269252437703142 0.995855173010111 0.999971973786806 GO:0004842 ubiquitin-protein transferase activity 14/1065 449/18639 0.0311804008908686 0.545700931647793 0.996538811200773 0.999971973786806 GO:0140767 enzyme-substrate adaptor activity 2/1065 139/18639 0.0143884892086331 0.251818826628838 0.997418115908519 0.999971973786806 GO:0022836 gated channel activity 8/1065 318/18639 0.0251572327044025 0.440287005049163 0.998038465923825 0.999971973786806 GO:0019787 ubiquitin-like protein transferase activity 14/1065 479/18639 0.0292275574112735 0.511523420271105 0.998708503785839 0.999971973786806 GO:0140098 catalytic activity, acting on RNA 10/1065 387/18639 0.0258397932816537 0.452232776503985 0.998993394343099 0.999971973786806 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/1065 122/18639 0.00819672131147541 0.143454167628723 0.999254944441443 0.999971973786806 GO:0016755 aminoacyltransferase activity 14/1065 496/18639 0.0282258064516129 0.4939913675602 0.99927717422189 0.999971973786806 GO:0030371 translation repressor activity 5/1065 329/18639 0.0151975683890578 0.265978851834411 0.999971973786806 0.999971973786806