category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 22/170 238/9376 5.09817103311913 RPL13A/CFD/C1QB/RPS11/RPS26/C1QA/C1R/RPS28/PLCG2/RPL10/C1S/EGFR/RPS15/RPS17/RPS27/RPL28/UBA52/RPS20/PIK3R1/RPL18A/RPS8/RPL36 8.70217062988922 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 18/170 204/9376 4.86643598615917 FN1/TIMP3/LUM/DCN/CTSL/CD63/FLNA/KDR/MMP2/PLCG2/EGFR/IQGAP1/RAC1/WNT4/WNT5A/PIK3R1/COL1A1/RRAS 7.58697230177793 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 11/170 88/9376 6.89411764705882 CFD/SERPINE1/C1QB/SERPINE2/CD59/C1QA/C1R/F2R/C1S/A2M/TFPI 7.54872573277539 NA NA hsa04518 Integrin signaling 13/170 154/9376 4.65576776165011 FN1/FLT1/COL6A3/FBN1/FERMT2/FLNA/KDR/EGFR/RAC1/PIK3R1/COL1A1/ITGA1/TLN1 6.21585698742091 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 16/170 233/9376 3.78732643271901 FN1/VIM/DCN/MYL9/PDLIM1/COL6A3/FBN1/TPM2/FBLN1/TPM1/PDLIM2/COL1A1/ITGA1/NID1/TLN1/SPTBN1 5.85458408122505 Genetic Information Processing Translation hsa03010 Ribosome 15/170 222/9376 3.72655007949126 RPL13A/RPS11/RPS26/RPS28/RPL10/RPS15/RPS17/RPS27/RPL28/UBA52/RPS20/RPL18A/RPS8/MRPS6/RPL36 5.58674855997309 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 13/170 203/9376 3.53196175021733 FN1/MYL9/FLT1/COL6A3/FLNA/KDR/EGFR/RAC1/PIP5K1C/PIK3R1/COL1A1/ITGA1/TLN1 4.95591759416867 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 9/170 101/9376 4.9146185206756 FN1/SERPINE1/MMP2/PLCG2/RAC1/PIK3R1/COL1A1/TGFBR1/FOXO1 5.37486781252835 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 8/170 99/9376 4.45680332739156 CFD/C1QB/C1QA/HLA-DRB5/C1R/HLA-DRA/C1S/HLA-DPB1 4.69854189837805 Organismal Systems Immune system hsa04612 Antigen processing and presentation 7/170 82/9376 4.70817790530847 CD74/CTSL/HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1/TAPBP 4.58290408050531 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 12/170 232/9376 2.852738336714 FN1/MYL9/RGCC/F2R/EGFR/IQGAP1/RAC1/TMSB4X/PIP5K1C/PIK3R1/ITGA1/RRAS 3.8829749190476 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 7/170 98/9376 3.93949579831933 MARCKS/PLPP3/PLCG2/RAC1/PIP5K1C/PIK3R1/PLPP1 3.97496501936672 Cellular Processes Transport and catabolism hsa04145 Phagosome 9/170 155/9376 3.20242884250474 CTSL/HLA-E/HLA-DRB5/C1R/HLA-DRA/HLA-DPB1/RAC1/EEA1/TUBB 3.75710504364755 Human Diseases Immune disease hsa05310 Asthma 4/170 32/9376 6.89411764705882 PRG2/HLA-DRB5/HLA-DRA/HLA-DPB1 4.53839182265485 Human Diseases Cancer: specific types hsa05215 Prostate cancer 7/170 106/9376 3.64217536071032 ZEB1/IL1R2/EGFR/TCF7L2/HSP90B1/PIK3R1/FOXO1 3.71748579287671 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 7/170 110/9376 3.50973262032086 FLT1/SERPINE1/TIMP1/ELOB/PLCG2/EGFR/PIK3R1 3.59792630592954 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 10/170 205/9376 2.69038737446198 COX7A1/CTSD/MT-CO2/MMP2/RAC1/MT-ND1/PIK3R1/COL1A1/MT-ND2/TGFBR1 3.32528932171733 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 5/170 60/9376 4.59607843137255 HSPB1/KDR/PLCG2/RAC1/PIK3R1 3.79721033385582 Human Diseases Immune disease hsa05330 Allograft rejection 4/170 39/9376 5.65671191553545 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1 3.95988532352228 Environmental Information Processing Signal transduction hsa04072 Phospholipase D signaling pathway 8/170 149/9376 2.96123174101856 F2R/PLPP3/PLCG2/EGFR/PIP5K1C/PIK3R1/PLPP1/RRAS 3.27918864048927 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 14/170 362/9376 2.13298667533312 FN1/PRL/PRLR/FLT1/COL6A3/F2R/KDR/EGFR/RAC1/HSP90B1/PIK3R1/COL1A1/ITGA1/YWHAE 2.98741064594181 Organismal Systems Development and regeneration hsa04360 Axon guidance 9/170 184/9376 2.69769820971867 MYL9/SEMA3B/DPYSL2/PLCG2/RAC1/WNT4/WNT5A/PIK3R1/RRAS 3.16037784008012 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 6/170 93/9376 3.55825426944972 MYL9/EGFR/TCF7L2/IQGAP1/RAC1/TGFBR1 3.36911333198714 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 4/170 44/9376 5.01390374331551 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1 3.62644036693833 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 5/170 70/9376 3.93949579831933 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1/RAC1 3.35440080229469 Human Diseases Immune disease hsa05332 Graft-versus-host disease 4/170 45/9376 4.90248366013072 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1 3.56580729484288 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 6/170 99/9376 3.34260249554367 PLPP3/EGFR/RAC1/PIP5K1C/PIK3R1/PLPP1 3.18410245944262 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 6/170 100/9376 3.30917647058823 CD59/HLA-DRB5/IL1R2/HLA-DRA/HLA-DPB1/ITGA1 3.15465134223416 NA NA hsa03272 Virion - Hepatitis viruses 4/170 48/9376 4.59607843137255 CD81/CD63/EGFR/TGOLN2 3.39414286732988 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 9/170 205/9376 2.42134863701578 VIM/HLA-E/HLA-DRB5/PLCG2/HLA-DRA/HLA-DPB1/RAC1/PIK3R1/TAPBP 2.79604279853923 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 4/170 52/9376 4.24253393665158 LRPAP1/APOE/NPC2/APOA1 3.18610205824365 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 7/170 142/9376 2.71880695940348 CTSL/IL1R2/KDR/MMP2/RAC1/HSP90B1/PIK3R1 2.80447100430366 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 5/170 80/9376 3.44705882352941 KDR/PLCG2/EGFR/PIK3R1/AXL 2.9868675101445 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 9/170 212/9376 2.34139844617092 FLT1/RASGRP2/F2R/KDR/EGFR/RAC1/PIK3R1/RRAS/TLN1 2.68446535069432 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 7/170 143/9376 2.69979432332374 C1QB/C1QA/HLA-DRB5/C1R/HLA-DRA/C1S/HLA-DPB1 2.78334851163568 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 4/170 54/9376 4.08540305010893 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1 3.08978918520279 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 6/170 116/9376 2.852738336714 THY1/MYL9/MMP2/PLCG2/RAC1/PIK3R1 2.72842614747029 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 5/170 87/9376 3.16970926301555 EGFR/TCF7L2/RAC1/PIK3R1/TGFBR1 2.76281179595381 Cellular Processes Cell growth and death hsa04218 Cellular senescence 7/170 157/9376 2.45904833270888 SERPINE1/IGFBP3/HLA-E/PIK3R1/RRAS/TGFBR1/FOXO1 2.50525657717022 Organismal Systems Digestive system hsa04978 Mineral absorption 4/170 61/9376 3.61658630665381 FTL/ATOX1/SLC40A1/ATP2B4 2.78601317443653 Organismal Systems Immune system hsa04611 Platelet activation 6/170 126/9376 2.62633053221288 RASGRP2/F2R/PLCG2/PIK3R1/COL1A1/TLN1 2.49745594011469 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 5/170 95/9376 2.90278637770898 FLT1/CTSL/HLA-DRB5/HLA-DRA/HLA-DPB1 2.53296426902605 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 7/170 170/9376 2.27100346020761 PLCG2/EGFR/TCF7L2/WNT4/WNT5A/PIK3R1/TGFBR1 2.27253364610182 Cellular Processes Transport and catabolism hsa04144 Endocytosis 9/170 250/9376 1.98550588235294 HLA-E/RAB31/EGFR/EEA1/PIP5K1C/EHD2/DAB2/TGFBR1/AP2B1 2.14616746369848 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 5/170 103/9376 2.67732724157624 SERPINE1/C1QB/C1QA/PIK3R1/TGFBR1 2.32595279497621 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 5/170 103/9376 2.67732724157624 FN1/IL1R2/HSPB1/PIK3R1/COL1A1 2.32595279497621 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 11/170 333/9376 1.82186892775128 FN1/HLA-E/COL6A3/EGFR/TCF7L2/WNT4/WNT5A/PIK3R1/COL1A1/ITGA1/FOXO1 2.07511909339959 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 9/170 253/9376 1.96196233434085 MYL9/CBX3/PLCG2/EGFR/UBA52/RAC1/PIK3R1/TLN1/FOXO1 2.10777429733657 Organismal Systems Digestive system hsa04975 Fat digestion and absorption 3/170 43/9376 3.84787961696306 PLPP3/APOA1/PLPP1 2.54343027057434 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 7/170 180/9376 2.14483660130719 CD74/HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1/PIK3R1/TAPBP 2.1074384069076 NA NA hsa04517 IgSF CAM signaling 10/170 299/9376 1.84457997245721 MYL9/KDR/PLCG2/IQGAP1/CLMP/RAC1/PIK3R1/TUBB/FOXO1/SPTBN1 2.01687888277338 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 5/170 110/9376 2.50695187165775 EMP3/DCN/FBN1/LTBP1/TGFBR1 2.16035036438026 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 4/170 77/9376 2.86508785332315 EGFR/RAC1/PIK3R1/TGFBR1 2.23306387568065 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 8/170 224/9376 1.96974789915966 HLA-E/HLA-DRB5/IL1R2/HLA-DRA/HLA-DPB1/PIK3R1/TLN1/TGFBR1 1.99617891737617 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 4/170 78/9376 2.82835595776772 C1QB/C1QA/C1R/C1S 2.20337235055049 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2/170 21/9376 5.25266106442577 CHSY1/CHPF 2.65108184760016 Human Diseases Cancer: specific types hsa05226 Gastric cancer 6/170 150/9376 2.20611764705882 EGFR/TCF7L2/WNT4/WNT5A/PIK3R1/TGFBR1 2.02349991180952 Metabolism Amino acid metabolism hsa00340 Histidine metabolism 2/170 22/9376 5.01390374331551 AOC1/MAOB 2.56126328925285 Organismal Systems Immune system hsa04672 Intestinal immune network for IgA production 3/170 50/9376 3.30917647058823 HLA-DRB5/HLA-DRA/HLA-DPB1 2.22468759833367 Human Diseases Neurodegenerative disease hsa05020 Prion disease 9/170 275/9376 1.80500534759358 COX7A1/C1QB/MT-CO2/C1QA/RAC1/MT-ND1/PIK3R1/TUBB/MT-ND2 1.84117542148308 Metabolism Lipid metabolism hsa00565 Ether lipid metabolism 3/170 51/9376 3.24429065743945 PLPP3/PLD3/PLPP1 2.1838076499193 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 6/170 157/9376 2.10775571375047 C1QB/MFGE8/C1QA/BSG/RAC1/AXL 1.90207015460466 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 6/170 157/9376 2.10775571375047 SERPINE1/TCF7L2/WNT4/WNT5A/YWHAE/TGFBR1 1.90207015460466 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 8/170 238/9376 1.85388037567968 FLT1/RASGRP2/KDR/PLCG2/EGFR/RAC1/PIK3R1/RRAS 1.8131533961439 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 7/170 201/9376 1.92074919520047 FLT1/IGFBP3/ZEB1/IL1R2/NUPR1/HPGD/FOXO1 1.79312660277405 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 4/170 87/9376 2.53576741041244 COX7A1/MT-CO2/TPM2/TPM1 1.95557828399174 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 3/170 55/9376 3.0083422459893 PSAP/PLPP3/PLPP1 2.0298429060506 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 4/170 89/9376 2.4787838730998 FN1/COL6A3/COL1A1/ITGA1 1.9047439371664 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 8/170 248/9376 1.77912713472486 MYL9/AHNAK2/FLNA/TCF7L2/RAC1/HSP90B1/TUBB/RRAS 1.68974421449604 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 4/170 91/9376 2.42430510665805 CD81/PLCG2/RAC1/PIK3R1 1.8552711325044 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 6/170 169/9376 1.95809258614688 CTSL/CTSD/IRS2/UBA52/PIK3R1/RRAS 1.70791547620015 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 5/170 130/9376 2.12126696832579 MMP2/EGFR/PIK3R1/COL1A1/TGFBR1 1.74935670355619 Human Diseases Cancer: specific types hsa05213 Endometrial cancer 3/170 59/9376 2.80438683948156 EGFR/TCF7L2/PIK3R1 1.88926214417562 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 5/170 133/9376 2.0734188412207 IRS2/EGFR/PIK3R1/TGFBR1/FOXO1 1.69419412565572 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 5/170 133/9376 2.0734188412207 HLA-E/PLCG2/TYROBP/RAC1/PIK3R1 1.69419412565572 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 11/170 388/9376 1.56361431170406 COX7A1/APOE/MT-CO2/IRS2/DKK1/WNT4/MT-ND1/WNT5A/PIK3R1/TUBB/MT-ND2 1.54078115142326 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 9/170 300/9376 1.65458823529412 FLT1/RASGRP2/FLNA/HSPB1/KDR/EGFR/RAC1/RRAS/TGFBR1 1.56587176414894 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 3/170 62/9376 2.66869070208729 IRS2/PIK3R1/FOXO1 1.79134067635939 NA NA hsa04081 Hormone signaling 7/170 219/9376 1.76287939833468 PRL/PRLR/RAMP1/IRS2/NPR3/PIK3R1/SLC40A1 1.55230104842092 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 5/170 138/9376 1.99829497016198 COX7A1/ATP5ME/MT-CO2/MT-ND1/MT-ND2 1.60540296528582 Human Diseases Cancer: specific types hsa05217 Basal cell carcinoma 3/170 63/9376 2.62633053221288 TCF7L2/WNT4/WNT5A 1.75998473990099 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 5/170 139/9376 1.98391874735506 CTSD/MMP2/EGFR/HSP90B1/PIK3R1 1.58809243704903 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 6/170 181/9376 1.82827429314267 CD74/CTSD/HLA-DRB5/HLA-DRA/HLA-DPB1/EEA1 1.52901665759586 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 5/170 142/9376 1.94200497100249 PLCG2/TYROBP/RAC1/PIK3R1/TGFBR1 1.5370112464539 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 7/170 226/9376 1.70827693909422 MYL9/FXYD1/F2R/RAC1/PIK3R1/ATP2B4/RRAS 1.46460795244043 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 3/170 66/9376 2.50695187165775 HLA-DRB5/HLA-DRA/HLA-DPB1 1.66944118428714 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 7/170 227/9376 1.70075149002332 HLA-E/EGFR/CCL4/RAC1/AKAP13/PIK3R1/TAPBP 1.45232816024249 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 7/170 227/9376 1.70075149002332 COX7A1/MT-CO2/EGFR/RAC1/MT-ND1/PIK3R1/MT-ND2 1.45232816024249 Organismal Systems Immune system hsa04664 Fc epsilon RI signaling pathway 3/170 69/9376 2.39795396419437 PLCG2/RAC1/PIK3R1 1.58375198415018 Human Diseases Cancer: specific types hsa05224 Breast cancer 5/170 148/9376 1.86327503974563 EGFR/TCF7L2/WNT4/WNT5A/PIK3R1 1.43847017763657 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 9/170 323/9376 1.53676925878711 TIMP3/VIM/IRS2/ZEB1/MARCKS/PLCG2/EGFR/TPM1/PIK3R1 1.33403508017408 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 3/170 70/9376 2.3636974789916 ELOB/RAC1/PIK3R1 1.55618113835444 Organismal Systems Immune system hsa04659 Th17 cell differentiation 4/170 109/9376 2.02396114409066 HLA-DRB5/HLA-DRA/HLA-DPB1/TGFBR1 1.46117340174305 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 3/170 71/9376 2.33040596520298 PRL/PRLR/PIK3R1 1.52907850308378 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 3/170 71/9376 2.33040596520298 PLCG2/EGFR/RAC1 1.52907850308378 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 3/170 71/9376 2.33040596520298 EGFR/PIK3R1/SLC16A3 1.52907850308378 Metabolism Glycan biosynthesis and metabolism hsa00512 Mucin type O-glycan biosynthesis 2/170 36/9376 3.0640522875817 GALNT6/GALNT15 1.68606037037093 Human Diseases Infectious disease: parasitic hsa05143 African trypanosomiasis 2/170 37/9376 2.981240063593 APOA1/HBB 1.6408254722341 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 6/170 196/9376 1.68835534213685 HLA-E/PLCG2/TCF7L2/UBA52/RAC1/PIK3R1 1.32340873215344 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 3/170 73/9376 2.2665592264303 PLCG2/EGFR/PIK3R1 1.4762164350976 Human Diseases Endocrine and metabolic disease hsa04934 Cushing syndrome 5/170 155/9376 1.77912713472486 EGFR/TCF7L2/WNT4/WNT5A/KCNK3 1.32910649870911 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 3/170 75/9376 2.20611764705882 SERPINE1/CD82/IGFBP3 1.42504997518128 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 5/170 157/9376 1.75646309479206 COX7A1/MT-CO2/IRS2/RAC1/PIK3R1 1.2988837320391 Human Diseases Cancer: specific types hsa05214 Glioma 3/170 76/9376 2.17708978328173 PLCG2/EGFR/PIK3R1 1.40006927726831 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 3/170 78/9376 2.12126696832579 FN1/RAC1/PIK3R1 1.35125144811024 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 3/170 78/9376 2.12126696832579 HLA-DRB5/HLA-DRA/HLA-DPB1 1.35125144811024 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 7/170 250/9376 1.54428235294118 PSAP/CTSL/CTSD/CD68/NPC2/CD63/AP2B1 1.18530096863416 Human Diseases Cancer: specific types hsa05219 Bladder cancer 2/170 41/9376 2.69038737446198 MMP2/EGFR 1.47399367902988 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 4/170 120/9376 1.83843137254902 PLCG2/RAC1/PIK3R1/YWHAE 1.25609094283763 Metabolism Amino acid metabolism hsa00380 Tryptophan metabolism 2/170 42/9376 2.62633053221288 AOC1/MAOB 1.43540407860834 Cellular Processes Cell growth and death hsa04216 Ferroptosis 2/170 42/9376 2.62633053221288 FTL/SLC40A1 1.43540407860834 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 4/170 122/9376 1.8082931533269 IRS2/PIK3R1/EEF2/FOXO1 1.22112094789815 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 4/170 122/9376 1.8082931533269 PLCG2/WNT4/PIK3R1/FOXO1 1.22112094789815 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 4/170 122/9376 1.8082931533269 IGFBP3/IRS2/PLCG2/PIK3R1 1.22112094789815 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 6/170 214/9376 1.54634414513469 ELOB/HLA-E/PLCG2/RAC1/PIK3R1/TAPBP 1.09863302525516 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 8/170 308/9376 1.43254392666157 COX7A1/TGM2/MT-CO2/POLR2L/MT-ND1/TUBB/MT-ND2/AP2B1 1.04887669182491 NA NA hsa04519 Cadherin signaling 10/170 404/9376 1.36517181129878 VIM/CDH11/KDR/EGFR/TCF7L2/RAC1/WNT4/WNT5A/YWHAE/RRAS 1.01957202167485 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 3/170 86/9376 1.92393980848153 PLCG2/EGFR/PIK3R1 1.16966006303665 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 5/170 174/9376 1.58485463150778 SSR4/RRBP1/DNAJC1/HSP90B1/SELENOS 1.05817149114121 Human Diseases Endocrine and metabolic disease hsa04930 Type II diabetes mellitus 2/170 47/9376 2.34693366708385 IRS2/PIK3R1 1.2579176315503 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 7/170 268/9376 1.44056189640035 COX7A1/MT-CO2/UBA52/MT-ND1/MAOB/TUBB/MT-ND2 0.9943457745497 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 5/170 178/9376 1.54923992068738 DKK1/TCF7L2/RAC1/WNT4/WNT5A 1.00531001232496 Metabolism Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis 2/170 49/9376 2.25114045618247 GALNT6/GALNT15 1.19318485611809 Organismal Systems Aging hsa04211 Longevity regulating pathway 3/170 90/9376 1.83843137254902 IRS2/PIK3R1/FOXO1 1.08604807236722 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 2/170 50/9376 2.20611764705882 AOC1/MAOB 1.16198783666786 Human Diseases Infectious disease: parasitic hsa05144 Malaria 2/170 50/9376 2.20611764705882 CD81/HBB 1.16198783666786 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 3/170 93/9376 1.77912713472486 HLA-DRB5/HLA-DRA/HLA-DPB1 1.02607768440433 Metabolism Glycan biosynthesis and metabolism hsa00604 Glycosphingolipid biosynthesis - ganglio series 1/170 15/9376 3.67686274509804 ST3GAL5 1.40988997994127 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 4/170 138/9376 1.59863597612958 FN1/RAC1/PIP5K1C/PIK3R1 0.96269339216371 Organismal Systems Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/170 53/9376 2.08124306326304 ATP2B4/AP2B1 1.07265000854611 Metabolism Amino acid metabolism hsa00360 Phenylalanine metabolism 1/170 16/9376 3.44705882352941 MAOB 1.33119319793962 Environmental Information Processing Signal transduction hsa04070 Phosphatidylinositol signaling system 3/170 98/9376 1.68835534213685 PLCG2/PIP5K1C/PIK3R1 0.930835964267286 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 4/170 144/9376 1.53202614379085 C1QB/C1QA/TCF7L2/FOXO1 0.874260658767644 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 3/170 99/9376 1.67130124777184 MMP2/EGFR/PIK3R1 0.912443301039485 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 3/170 99/9376 1.67130124777184 TPM2/TPM1/ITGA1 0.912443301039485 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 5/170 193/9376 1.42883267296556 RASGRP2/PLCG2/CCL4/RAC1/PIK3R1 0.817991598311325 Organismal Systems Endocrine system hsa04916 Melanogenesis 3/170 101/9376 1.63820617355853 TCF7L2/WNT4/WNT5A 0.876272822472784 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 3/170 103/9376 1.60639634494575 COL6A3/SLC7A8/COL1A1 0.840890935548429 Organismal Systems Endocrine system hsa04923 Regulation of lipolysis in adipocytes 2/170 59/9376 1.86959122632104 IRS2/PIK3R1 0.910495326638289 Metabolism Lipid metabolism hsa00564 Glycerophospholipid metabolism 3/170 104/9376 1.59095022624434 PLPP3/PLD3/PLPP1 0.823484587111228 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 3/170 105/9376 1.57579831932773 PLCG2/PIK3R1/RRAS 0.806262323018848 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 3/170 105/9376 1.57579831932773 TPM2/TPM1/ITGA1 0.806262323018848 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 6/170 254/9376 1.30282538212135 FLT1/F2R/KDR/PLCG2/EGFR/ATP2B4 0.664873022880274 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 4/170 156/9376 1.41417797888386 CD81/EGFR/PIK3R1/YWHAE 0.708856713317493 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 3/170 109/9376 1.517970858068 CCL4/RAC1/PIK3R1 0.739134726991132 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 3/170 109/9376 1.517970858068 IRS2/PIK3R1/FOXO1 0.739134726991132 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 2/170 63/9376 1.75088702147526 PTGDS/HPGD 0.812596008628073 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 4/170 160/9376 1.37882352941176 HLA-E/HLA-DRB5/HLA-DRA/HLA-DPB1 0.656750357522617 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 2/170 65/9376 1.69701357466063 PLPP3/PLPP1 0.76625684104929 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 3/170 112/9376 1.47731092436975 HLA-DRB5/HLA-DRA/HLA-DPB1 0.690535048076874 Metabolism Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis 1/170 23/9376 2.39795396419437 PCYOX1 0.912128308199548 Metabolism Metabolism of cofactors and vitamins hsa00830 Retinol metabolism 2/170 68/9376 1.62214532871972 DHRS3/ALDH1A2 0.699669153207711 Human Diseases Cancer: specific types hsa05221 Acute myeloid leukemia 2/170 68/9376 1.62214532871972 TCF7L2/PIK3R1 0.699669153207711 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 4/170 168/9376 1.31316526610644 PRL/PRLR/EGFR/PIK3R1 0.55657050381374 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 10/170 480/9376 1.14901960784314 COX7A1/MT-CO2/DKK1/UBA52/RAC1/WNT4/MT-ND1/WNT5A/TUBB/MT-ND2 0.455450581983904 Organismal Systems Digestive system hsa04977 Vitamin digestion and absorption 1/170 26/9376 2.12126696832579 APOA1 0.777972974388074 Human Diseases Cancer: specific types hsa05218 Melanoma 2/170 73/9376 1.51103948428687 EGFR/PIK3R1 0.5956333268475 Human Diseases Infectious disease: viral hsa05164 Influenza A 4/170 173/9376 1.27521251275076 HLA-DRB5/HLA-DRA/HLA-DPB1/PIK3R1 0.496479281472392 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 3/170 125/9376 1.32367058823529 CTSD/RAC1/PIK3R1 0.495037976408544 Human Diseases Cancer: specific types hsa05220 Chronic myeloid leukemia 2/170 77/9376 1.43254392666157 PIK3R1/TGFBR1 0.517883495703443 Metabolism Carbohydrate metabolism hsa00562 Inositol phosphate metabolism 2/170 78/9376 1.41417797888386 PLCG2/PIP5K1C 0.499130545669993 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 5/170 235/9376 1.17346683354193 COX7A1/ATP5ME/MT-CO2/MT-ND1/MT-ND2 0.365955384234675 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 3/170 134/9376 1.23476733977173 MYL9/CALD1/RAMP1 0.37194755614092 Organismal Systems Immune system hsa04623 Cytosolic DNA-sensing pathway 2/170 83/9376 1.32898653437279 CCL4/POLR2L 0.409085243174047 Cellular Processes Cell growth and death hsa04210 Apoptosis 3/170 137/9376 1.20772863890082 CTSL/CTSD/PIK3R1 0.332827182936532 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 6/170 298/9376 1.11046190288196 IL1RL1/PRL/PRLR/IL1R2/CCL4/TGFBR1 0.263329901574424 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 3/170 138/9376 1.19897698209719 IRS2/PIK3R1/FOXO1 0.319983819041598 Genetic Information Processing Transcription hsa03020 RNA polymerase 1/170 34/9376 1.62214532871972 POLR2L 0.493839683129879 Organismal Systems Environmental adaptation hsa04710 Circadian rhythm 1/170 34/9376 1.62214532871972 RORB 0.493839683129879 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 2/170 86/9376 1.28262653898769 TCF7L2/ITGA1 0.357790596718053 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 3/170 140/9376 1.1818487394958 SERPINE1/RRAS/TGFBR1 0.294582514136376 Cellular Processes Cell motility hsa04814 Motor proteins 4/170 194/9376 1.13717404487568 MYL9/TPM2/TPM1/TUBB 0.262348617118691 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 2/170 89/9376 1.2393919365499 EGFR/TUBB 0.308348196139122 Genetic Information Processing Replication and repair hsa03030 DNA replication 1/170 36/9376 1.53202614379085 RNASEH2C 0.434595674946782 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 3/170 144/9376 1.14901960784314 WNT4/WNT5A/PIK3R1 0.244878906878406 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 2/170 90/9376 1.22562091503268 EGFR/PIK3R1 0.292254283271876 Metabolism Amino acid metabolism hsa00350 Tyrosine metabolism 1/170 37/9376 1.4906200317965 MAOB 0.406322212109969 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 1/170 37/9376 1.4906200317965 TCF7L2 0.406322212109969 Organismal Systems Excretory system hsa04960 Aldosterone-regulated sodium reabsorption 1/170 38/9376 1.45139318885449 PIK3R1 0.378873717059309 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 2/170 93/9376 1.18608475648324 MMP2/EGFR 0.245065801876728 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 2/170 93/9376 1.18608475648324 FN1/PIK3R1 0.245065801876728 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 4/170 205/9376 1.07615494978479 HLA-E/RAC1/PIK3R1/YWHAE 0.149810182648749 Metabolism Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism 1/170 41/9376 1.34519368723099 MAOB 0.301003971460354 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 3/170 154/9376 1.07440794499618 TPM2/TPM1/ATP2B4 0.126514914233877 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 3/170 154/9376 1.07440794499618 MYL9/EGFR/EEF2 0.126514914233877 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 2/170 98/9376 1.12557022809124 ATP2B4/KCNK3 0.169803700492428 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 2/170 99/9376 1.11420083184789 PLCG2/PIK3R1 0.155223581571773 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 3/170 158/9376 1.04720774385704 WNT4/WNT5A/PIK3R1 0.0813201274099202 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 4/170 216/9376 1.02135076252723 APOA1/RAC1/HSP90B1/PIK3R1 0.0431387088564186 Organismal Systems Digestive system hsa04972 Pancreatic secretion 2/170 102/9376 1.08143021914648 RAC1/ATP2B4 0.112363887766745 Metabolism Metabolism of cofactors and vitamins hsa00860 Porphyrin metabolism 1/170 46/9376 1.19897698209719 FTL 0.183829644430114 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 2/170 105/9376 1.05053221288515 PLCG2/CCL4 0.0707577948397549 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 2/170 105/9376 1.05053221288515 UBA52/RRAS 0.0707577948397549 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 3/170 166/9376 0.996739900779589 MYL9/IRS2/ATP2B4 -0.00575876903077581 Organismal Systems Digestive system hsa04973 Carbohydrate digestion and absorption 1/170 48/9376 1.14901960784314 PIK3R1 0.140651503771576 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/170 49/9376 1.12557022809124 MAOB 0.119753536701163 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 2/170 110/9376 1.0027807486631 PIK3R1/CPEB4 0.00398645205634398 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/170 51/9376 1.08143021914648 PLCG2 0.0792356974428524 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 2/170 115/9376 0.959181585677749 EGFR/AKAP13 -0.0598481487703829 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 6/170 368/9376 0.89923273657289 COX7A1/MT-CO2/RAC1/MT-ND1/TUBB/MT-ND2 -0.267980873640549 Genetic Information Processing Replication and repair hsa03420 Nucleotide excision repair 1/170 63/9376 0.875443510737628 POLR2L -0.134792722644846 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 3/170 195/9376 0.848506787330317 PLCG2/RAC1/PIK3R1 -0.290495962879704 Organismal Systems Endocrine system hsa04927 Cortisol synthesis and secretion 1/170 65/9376 0.848506787330317 KCNK3 -0.166542969607441 Organismal Systems Endocrine system hsa04929 GnRH secretion 1/170 65/9376 0.848506787330317 PIK3R1 -0.166542969607441 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 1/170 66/9376 0.835650623885918 HSD11B1 -0.182070590479387 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 3/170 200/9376 0.827294117647059 F2R/RAC1/TUBB -0.335482629900843 Cellular Processes Cell growth and death hsa04114 Oocyte meiosis 2/170 138/9376 0.799317988064791 CPEB4/YWHAE -0.322725754080515 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/170 69/9376 0.799317988064791 MAOB -0.227354077978383 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 1/170 70/9376 0.787899159663866 IRS2 -0.242038525585815 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 1/170 70/9376 0.787899159663866 HSD11B1 -0.242038525585815 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 2/170 142/9376 0.776801988400994 ELOB/UBA52 -0.364178390320739 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/170 73/9376 0.755519742143433 MAOB -0.284949781402604 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 1/170 73/9376 0.755519742143433 MAP1B -0.284949781402604 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/170 75/9376 0.735372549019608 PIK3R1 -0.312662154783564 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 1/170 75/9376 0.735372549019608 HSP90B1 -0.312662154783564 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 1/170 76/9376 0.725696594427245 APOA1 -0.326265486496507 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 2/170 149/9376 0.740307935254639 MT-ND1/MT-ND2 -0.434206346413673 NA NA hsa04382 Cornified envelope formation 3/170 217/9376 0.762483057739225 S100A4/S100A6/DST -0.481033192302037 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 3/170 217/9376 0.762483057739225 EGFR/HSP90B1/PIK3R1 -0.481033192302037 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1/170 79/9376 0.698138495904691 HSD11B1 -0.366120861379462 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 1/170 79/9376 0.698138495904691 AP2B1 -0.366120861379462 Genetic Information Processing Chromosome hsa03083 Polycomb repressive complex 1/170 83/9376 0.664493267186393 CBX3 -0.417192921410155 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/170 85/9376 0.648858131487889 GUK1 -0.441911661516795 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 2/170 163/9376 0.676723204619271 PIK3R1/TGFBR1 -0.565773253359263 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 5/170 370/9376 0.745310015898251 PRL/PRLR/NPW/F2R/PGRMC2 -0.679237055488807 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 2/170 170/9376 0.648858131487889 MYL9/RAC1 -0.627835986078658 Organismal Systems Digestive system hsa04970 Salivary secretion 1/170 93/9376 0.593042378241619 ATP2B4 -0.535946080650873 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/170 94/9376 0.586733416770964 HSP90B1 -0.547202468634802 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 1/170 100/9376 0.551529411764706 CCL4 -0.612672249673762 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 1/170 107/9376 0.51544804837823 FOXO1 -0.684999742891159 Organismal Systems Nervous system hsa04725 Cholinergic synapse 1/170 115/9376 0.479590792838875 PIK3R1 -0.763026397982302 Organismal Systems Nervous system hsa04726 Serotonergic synapse 1/170 115/9376 0.479590792838875 MAOB -0.763026397982302 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 1/170 119/9376 0.463470093919921 PIK3R1 -0.800399662641172 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/170 122/9376 0.452073288331726 PIK3R1 -0.827774901689009 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 1/170 128/9376 0.430882352941176 GUK1 -0.8809631451624 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 1/170 133/9376 0.41468376824414 MAOB -0.923813970289565 Human Diseases Infectious disease: viral hsa05162 Measles 1/170 136/9376 0.405536332179931 PIK3R1 -0.94892830017473 Human Diseases Neurodegenerative disease hsa05017 Spinocerebellar ataxia 1/170 144/9376 0.383006535947712 PIK3R1 -1.01388459690007 Metabolism Global and overview maps hsa01240 Biosynthesis of cofactors 1/170 154/9376 0.358135981665393 DHRS3 -1.09135350040353 Cellular Processes Cell growth and death hsa04110 Cell cycle 1/170 158/9376 0.349069247952345 YWHAE -1.12129424892354 Cellular Processes Cell growth and death hsa04217 Necroptosis 1/170 168/9376 0.328291316526611 FTL -1.19378896971856 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 1/170 187/9376 0.294935514312677 YWHAE -1.32339695425663 Human Diseases Substance dependence hsa05034 Alcoholism 1/170 191/9376 0.288758854327071 MAOB -1.34948664122194