category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	54/539	238/9376	3.94680469590434	RPL13A/RPS26/C1QB/C1QA/RPS20/RPL28/RPS11/CFD/RPL7/RPL8/RPL37A/RPL10/RPS2/RPS16/RPL23/RPS8/RPL18A/C1QC/RPS14/RPLP0/EGFR/RPL27A/RPLP2/RPS15/RPS28/RPS9/UBA52/RPS5/RPL35/RPS27/RPL13/RPL18/RPL21/RPL31/RPL36/RPL11/CYBB/RPL10A/C5AR1/RPL4/MAPK14/RPS6/RPSA/VWF/RPL5/IL1B/FGG/PIK3R1/CCL2/NFKBIB/RPS3A/C2/CSF3/RPL12	11.3721308525118
Genetic Information Processing	Translation	hsa03010	Ribosome	47/539	222/9376	3.6827625399054	RPL13A/RPS26/RPS20/RPL28/RPS11/RPL7/RPL8/RPL37A/RPL10/RPS2/RPS16/RPL23/RPS8/RPL18A/RPS14/RPLP0/RPL27A/RPLP2/RPS15/RPS28/RPS9/UBA52/RPS5/RPL35/RPS27/RPL13/RPL18/RPL21/RPL31/RPL36/RPL11/RPL10A/RPL4/RPS6/RPSA/MRPL1/RPL5/MRPS26/MRPS11/MRPS25/MRPL16/MRPS9/MRPS17/RPS3A/MRPS18B/MRPS16/RPL12	9.99035360101586
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/539	99/9376	3.51417702067053	C1QB/C1QA/HLA-DRA/KRT19/HLA-DRB5/CFD/C1QC/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCGR3A/ITGB2/HLA-DPB1/C5AR1/KRT18/FGG/KRT14/HLA-DMA/C2/FPR3	6.21065299750577
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	20/539	100/9376	3.47903525046382	HLA-DRA/HLA-DRB5/CD14/IL1R2/HLA-DRB1/HLA-DPA1/CD44/HLA-DQA1/IL7R/HLA-DPB1/CD4/CD3D/IL1B/CSF1R/CD2/CD3G/CD7/HLA-DMA/CD3E/CSF3	6.15502647804895
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/539	95/9376	3.47903525046382	HLA-DRA/FLT1/HLA-DRB5/CTSL/HLA-DRB1/HLA-DPA1/CTSK/HLA-DQA1/ITGB2/HLA-DPB1/VEGFA/CCL5/ACP5/IL15/LTB/IL1B/CCL2/ATP6V1H/HLA-DMA	5.99756152547767
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/539	224/9376	2.32971110522131	HLA-DRA/HLA-DRB5/IL1R2/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/ITGB2/HLA-DPB1/IL2RB/IL15/SLC2A1/MAP3K3/CD4/CD3D/GPS2/PIK3R1/AKT3/CCNE2/TGFBR1/LTBR/CD3G/NFKB2/SPI1/STAT5A/CREB3L1/HLA-DMA/CD3E/VAC14/CREB3	4.97451669298351
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/539	109/9376	3.03218668618407	HLA-DRA/HLA-DRB5/EBI3/HLA-DRB1/HLA-DPA1/HLA-DQA1/GATA3/HLA-DPB1/IL2RB/MAPK14/CD4/CD3D/IL1B/TGFBR1/CD3G/STAT5A/NFKBIB/HLA-DMA/CD3E	5.27029424022411
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/539	93/9376	3.17976340096156	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DQA1/GATA3/HLA-DPB1/IL2RB/MAPK14/CD4/CD3D/RUNX3/CD3G/STAT5A/NFKBIB/HLA-DMA/CD3E	5.21716111488974
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/539	44/9376	4.34879406307978	HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/GZMB/IL1B/ICA1/HLA-DMA	5.49863646122515
Human Diseases	Immune disease	hsa05310	Asthma	9/539	32/9376	4.89239332096475	HLA-DRA/HLA-DRB5/PRG2/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCER1G/HLA-DPB1/HLA-DMA	5.44694369806381
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	26/539	205/9376	2.20621747590389	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/CTSD/MT-ND5/GAPDH/CYBB/MAPK14/MMP2/SLC2A1/PDHA1/COL1A1/PIK3R1/AKT3/ATP5F1D/TGFBR1/PTPA/NDUFA13/COX4I1/NDUFS1	4.31242736678434
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/539	45/9376	3.86559472273758	HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/GZMB/IL1B/HLA-DMA	4.75865833498633
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/539	204/9376	2.13176179562734	FN1/TIMP3/LUM/DCN/ACTB/CTSL/EGFR/CD63/CD44/WNT4/CAV1/FLNA/HCLS1/MAPK14/VEGFA/MMP2/NUDT16L1/RPS6/COL1A1/PIK3R1/AKT3/WNT10B/ARHGEF1/TWIST2/CTTN	4.03613499557472
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/539	39/9376	4.01427144284287	HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/GZMB/HLA-DMA	4.65841930077177
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/539	233/9376	2.01575003782239	FN1/DCN/FBLN1/MYL9/ACTB/TPM1/VCAN/COL6A3/TPM2/ANKRD1/ITGB8/PDLIM4/COL4A5/JUP/PDLIM2/LMOD1/COL1A1/PDLIM7/INF2/NID2/COL5A1/FBN2/FMNL1/FBN1/ZYX/NID1/FHL2	3.87746638171085
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/539	78/9376	2.89919604205318	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCGR3A/ITGB2/CYBB/HLA-DPB1/MAPK14/IL1B/NFKBIB/HLA-DMA	4.15958420350853
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/539	88/9376	2.76741440377804	SERPINE2/C1QB/C1QA/CFD/C1QC/CLU/F2R/ITGB2/C5AR1/SERPINB2/VWF/FGG/VSIG4/C2	4.11382881673797
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/539	50/9376	3.47903525046382	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/CXCR4/HLA-DQA1/HLA-DPB1/IL15/LTBR/HLA-DMA	4.34057827241008
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	26/539	235/9376	1.92457269174594	MT-CO2/MT-CYB/MT-CO3/MT-ND3/ACTB/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/MT-ND5/ATP5ME/TSC1/MAPK14/RPS6/ATP5F1D/PRKAG2/BMP8B/CREB3L1/CNR1/COX16/CREB3/PRKG1/NDUFA13/COX4I1/NDUFS1	3.54491423083635
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/539	250/9376	1.87867903525046	PSAP/CTSB/CTSD/CTSL/CD63/CD68/CTSK/LITAF/HEXB/NPC2/ABCA5/ACP5/CTSW/WDR7/AP3M2/IGF2R/DNASE2/VAMP8/DMXL1/ATP6V1H/NAGPA/GUSB/VPS39/CLTB/AP3B1/FUCA1/VPS33A	3.47766408239458
NA	NA	hsa04518	Integrin signaling	19/539	154/9376	2.14615810905236	FN1/SPP1/FLT1/ACTB/EGFR/COL6A3/LIMS2/ITGB2/ITGB8/FLNA/VEGFA/COL4A5/VWF/FGG/COL1A1/PIK3R1/AKT3/ITGAE/FBN1	3.54176650265028
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/539	155/9376	2.13231192770363	HLA-DRA/HLA-DRB5/ACTB/CD14/CTSL/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCGR3A/ITGB2/CYBB/HLA-DPB1/TUBA3E/CORO1A/STX18/ATP6V1H/HLA-DMA/MRC2	3.51051241722572
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/539	101/9376	2.41121254982641	FN1/CYBB/MAPK14/VEGFA/MMP2/COL4A5/IL1B/COL1A1/PIK3R1/AKT3/SELE/TGFBR1/CCL2/STAT5A	3.52146803845717
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/539	298/9376	1.75119224016635	IL1RL1/PRL/PRLR/CXCL14/EBI3/CCL4/IL1R2/CCL18/CXCR4/CSH1/IL7R/CCL4L2/IL2RB/INHA/CCL5/TNFRSF11B/IL15/CD4/LTB/IL1B/CXCL16/CSF1R/TGFBR1/CCL2/CCL13/LTBR/BMP8B/CCL14/GDF11/CSF3	3.25455585346156
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/539	50/9376	3.13113172541744	HBB/CD81/ITGB2/HBA2/IL1B/SELE/CCL2/LRP1/CSF3	3.73142901508158
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/539	70/9376	2.733527696793	HLA-DRA/HLA-DRB5/ACTB/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/ITGB2/CAV1/HLA-DPB1/HLA-DMA	3.59522333611021
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/539	103/9376	2.36439288866473	C1QB/C1QA/C1QC/MAPK14/CCL5/CD3D/IL1B/PIK3R1/AKT3/TGFBR1/CCL2/CD3G/CD3E/GNA11	3.43855141813201
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	28/539	275/9376	1.77114521841795	MT-CO2/MT-CYB/MT-CO3/MT-ND3/C1QB/C1QA/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/C1QC/MT-ND5/CAV1/CYBB/MAPK14/PSMA7/CCL5/TUBA3E/PSMD6/IL1B/PIK3R1/ATP5F1D/CREB3L1/CREB3/NDUFA13/COX4I1/NDUFS1	3.20542450750548
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/539	82/9376	2.54563554911987	CD74/HLA-DRA/HLA-DRB5/CTSB/CTSL/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/CD4/HLA-DMA	3.47168476207579
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/539	54/9376	2.89919604205318	HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/GZMB/HLA-DMA	3.45652514402439
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/539	205/9376	1.8667994026879	HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/CD44/HLA-DQA1/HLA-DPB1/MAPK14/PSMD6/CD3D/GADD45G/PIK3R1/AKT3/CCNE2/RUNX3/CD3G/NFKB2/NFKBIB/HLA-DMA/LYN/CD3E	3.09895150778058
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/539	181/9376	1.92211892290819	CD74/HLA-DRA/HLA-DRB5/CD14/CTSD/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCER1G/FCGR3A/ITGB2/HLA-DPB1/MAPK14/LSP1/CORO1A/IL1B/AKT3/ATP6V1H/HLA-DMA/MRC2	3.09369822585212
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/539	160/9376	1.9569573283859	HLA-DRA/HLA-DRB5/VCAN/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/PTPRC/ITGB2/HLA-DPB1/ITGB8/CD4/PTPRF/SELE/CD2/CLDN4/CLDN19/HLA-DMA	3.01515001090504
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	16/539	138/9376	2.01683202925439	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/MT-ND5/ATP5ME/ATP5F1D/ATP6V1H/NDUFA13/COX4I1/NDUFS1	2.97185335263522
Organismal Systems	Immune system	hsa04611	Platelet activation	15/539	126/9376	2.07085431575227	ACTB/RASGRP2/FCER1G/F2R/MAPK14/VWF/FGG/VAMP8/COL1A1/PIK3R1/AKT3/ARHGEF1/APBB1IP/LYN/PRKG1	2.98863164600538
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	29/539	308/9376	1.6378575042768	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/TGM2/MT-ND5/POLR2L/ATG14/GPX3/PSMA7/DCTN1/TUBA3E/PSMD6/ATP5F1D/CREB3L1/POLR2J/DCTN2/CLTB/ULK1/CREB3/NDUFA13/DCTN5/COX4I1/NDUFS1	2.81106485263151
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/539	52/9376	2.67618096189525	APOE/PLTP/LRPAP1/APOC1/APOA1/NPC2/LRP1/SOAT1	2.99329166463985
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/539	109/9376	2.07465404844173	IRS2/MLX/SLC2A1/PPP1R3B/PTPRF/NR1H3/PIK3R1/AKT3/PRKAG2/CREB3L1/PYGL/PTPA/CREB3	2.78701906682158
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/539	110/9376	2.05579355709226	FLT1/EGFR/ELOB/GAPDH/CYBB/VEGFA/SLC2A1/ARNT/RPS6/PDHA1/PIK3R1/AKT3/LTBR	2.75078593671889
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/539	16/9376	4.34879406307978	MIF/MAOA/MAOB/ALDH3B1	3.31083929720354
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/539	100/9376	2.08742115027829	CXCL14/CCL4/CCL18/CXCR4/CCL4L2/IL2RB/CCL5/CSF1R/CCL2/CCL13/LTBR/CCL14	2.69988334030388
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/539	66/9376	2.37206948895261	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DQA1/GATA3/HLA-DPB1/IL1B/HLA-DMA	2.76249071827626
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/539	142/9376	1.83751861820272	ACTB/CTSL/IL1R2/CAV1/GSTP1/MAPK14/VEGFA/MMP2/GSTA1/IL1B/PIK3R1/AKT3/SELE/CCL2/TXN2	2.48354080914893
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/539	169/9376	1.74981062893151	CTSB/CTSD/CTSL/UBA52/IRS2/ATG14/GABARAP/TSC1/WDFY3/VAMP8/PIK3R1/AKT3/VPS39/DAPK3/WDR45B/ULK1/VPS33A	2.42920108536485
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/539	157/9376	1.77275681552297	C1QB/C1QA/MFGE8/C1QC/AXL/ADAM9/MAPK14/SLC2A1/ARNT/NR1H3/LRP1/VPS39/ATP11C/DUSP4/VPS33A/BSG	2.41145052540932
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/539	157/9376	1.77275681552297	MT-CO2/MT-CYB/MT-CO3/MT-CO1/IRS2/MAPK14/MLX/ITCH/IL1B/NR1H3/PIK3R1/AKT3/PRKAG2/NDUFA13/COX4I1/NDUFS1	2.41145052540932
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/539	227/9376	1.60924538017049	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/EGFR/MT-ND5/MAPK14/VEGFA/ARNT/GSTA1/PIK3R1/AKT3/ATP5F1D/NDUFA13/COX4I1/NDUFS1	2.29480587343442
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	32/539	388/9376	1.43465371153147	MT-CO2/MT-CYB/MT-CO3/MT-ND3/APOE/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/DKK1/MT-ND5/IRS2/GAPDH/WNT4/ATG14/CYBB/PSMA7/TUBA3E/PSMD6/IL1B/PIK3R1/AKT3/ATP5F1D/LRP1/WNT10B/PSENEN/APH1B/ULK1/NDUFA13/COX4I1/NDUFS1	2.15951048329338
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/539	248/9376	1.54312047399605	MYL9/ACTB/CD14/PTPRC/GAPDH/AHNAK2/FLNA/MAPK14/KPNA1/DCTN1/TUBA3E/TCF7L1/IL1B/AKT3/PFN1/FYCO1/VPS39/EXOC7/DCTN2/DCTN5/VPS33A/TXN2	2.14072949437005
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/539	180/9376	1.64287775716347	CD74/HLA-DRA/HLA-DRB5/HLA-G/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/TSC1/CCL5/IL1B/PIK3R1/AKT3/CCL2/HCFC1/HLA-DMA/POU2F1	2.15076402939794
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/539	42/9376	2.48502517890273	FTL/GPX4/FTH1/CYBB/GCLC/SLC40A1	2.38205704403171
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	30/539	368/9376	1.41808502056949	MT-CO2/MT-CYB/MT-CO3/MT-ND3/ACTB/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/MT-ND5/ATG14/GPX3/NUP214/MAPK14/POM121/PSMA7/DCTN1/TUBA3E/PSMD6/NUP133/PFN1/ATP5F1D/NUP88/DCTN2/ULK1/NDUFA13/DCTN5/COX4I1/NDUFS1	2.02070037246309
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/539	90/9376	1.93279736136879	EGFR/MAPK14/MAP3K3/CD4/CD3D/PIK3R1/AKT3/CD3G/NFKBIB/CD3E	2.19594681403251
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	14/539	142/9376	1.71501737698921	TYROBP/CTSK/FCGR3A/MAPK14/ACP5/TNFRSF11B/IL1B/CSF1R/PIK3R1/AKT3/TGFBR1/NFKB2/SPI1/FHL2	2.12028102588818
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/539	22/9376	3.16275931860347	AOC1/MAOA/MAOB/ALDH3B1	2.50812075967654
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/539	68/9376	2.04649132380225	CD14/TCF7L1/JUP/CSF1R/PIK3R1/AKT3/SPI1/STAT5A	2.13889514361372
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/539	193/9376	1.53221759735453	CXCL14/CCL4/RASGRP2/CCL18/CXCR4/CCL4L2/GNB5/CCL5/CXCL16/PIK3R1/AKT3/PARD3/CCL2/CCL13/NFKBIB/CCL14/LYN	1.84502895304893
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/539	36/9376	2.41599670171099	GALNT6/GALNT15/GALNT10/C1GALT1/GALNT11	2.10216909640082
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/539	138/9376	1.63867602376919	IRS2/PHKG1/TSC1/RPS6/PHKB/PPP1R3B/PTPRF/PIK3R1/AKT3/PRKAG2/EXOC7/PYGL/TRIP10	1.86663227345226
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/539	37/9376	2.35069949355664	HBB/APOA1/HBA2/IL1B/SELE	2.0329982493266
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/539	49/9376	2.13002158191663	GALNT6/GALNT15/GALNT10/PLOD3/C1GALT1/GALNT11	1.9585803045844
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/539	155/9376	1.57117720988689	EGFR/CYP11A1/WNT4/KCNK3/RBBP5/HSD3B1/ARNT/TCF7L1/CCNE2/WNT10B/CREB3L1/MEN1/CREB3/GNA11	1.7708236031839
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/539	212/9376	1.4769489270837	FLT1/ACTB/EGFR/RASGRP2/F2R/FYB1/ITGB2/MAPK14/VEGFA/CSF1R/PIK3R1/AKT3/PFN1/PARD3/RALGDS/APBB1IP/CNR1/MAGI1	1.73470192196057
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/539	227/9376	1.45598391539235	CCL4/EGFR/HLA-G/CXCR4/CCL4L2/GNB5/TSC1/MAPK14/VEGFA/CCL5/IL1B/PIK3R1/AKT3/CCL2/ARHGEF1/CREB3L1/CREB3/GNA12/GNA11	1.71752564942087
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/539	38/9376	2.2888389805683	PTPRC/IL7R/CD4/CD3D/CD3E	1.96603443192331
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/539	116/9376	1.64954257565095	MYL9/THY1/ACTB/CXCR4/ITGB2/CYBB/MAPK14/MMP2/PIK3R1/CLDN4/CLDN19	1.73843604313114
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/539	130/9376	1.60570857713715	EGFR/GNB5/MAPK14/VEGFA/MMP2/COL4A5/COL1A1/PIK3R1/AKT3/TGFBR1/CREB3L1/CREB3	1.71745769602376
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/539	103/9376	1.68885206333195	FN1/CD14/IL1R2/ITGB2/COL4A5/IL1B/COL1A1/PIK3R1/HSPB1/GNA11	1.73604924133791
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/539	173/9376	1.50825227621264	HLA-DRA/HLA-DRB5/ACTB/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/KPNA1/CCL5/IL1B/PIK3R1/AKT3/CCL2/NFKBIB/HLA-DMA	1.66634631783113
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/539	203/9376	1.45673889797746	FN1/SPP1/FLT1/MYL9/ACTB/EGFR/COL6A3/CAV1/ITGB8/FLNA/VEGFA/COL4A5/VWF/COL1A1/PIK3R1/AKT3/ZYX	1.62475512366754
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/539	78/9376	1.7841206412635	C1QB/C1QA/CD14/C1QC/ITGB2/MAPK14/IL1B/C2	1.71736659134912
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/539	105/9376	1.65668345260182	CD14/CCL4/CCL4L2/LTB/IL1B/GADD45G/CCL13/LTBR/NFKB2/LYN	1.67114842960713
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/539	119/9376	1.60795746870177	MAPK14/CCL5/IL15/ITCH/IL1B/PIK3R1/AKT3/SELE/CCL2/CREB3L1/CREB3	1.64831093671424
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/539	133/9376	1.56948958667541	EGFR/IRS2/IL7R/GABARAP/MAPK14/GADD45G/PIK3R1/AKT3/TGFBR1/SETD7/PRKAG2/FBXO25	1.63355110034192
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/539	18/9376	2.89919604205318	HEXB/GBA2/FUCA1	1.99178346155197
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/539	106/9376	1.64105436342633	IL1R2/EGFR/FOLR2/GSTP1/TCF7L1/PIK3R1/AKT3/CCNE2/CREB3L1/CREB3	1.63921349006199
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/539	268/9376	1.36305485559217	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/UBA52/MT-ND5/MAOA/PSMA7/TUBA3E/MAOB/PSMD6/ATP5F1D/NDUFA13/COX4I1/TXN2/NDUFS1	1.48920926279537
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/539	109/9376	1.59588772957056	SPP1/CD14/CCL4/CTSK/CCL4L2/MAPK14/CCL5/IL1B/PIK3R1/AKT3	1.54538148012032
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/539	362/9376	1.29743027296303	FN1/SPP1/FLT1/PRL/PRLR/EGFR/COL6A3/CSH1/F2R/IL7R/ITGB8/GNB5/TSC1/IL2RB/VEGFA/COL4A5/RPS6/VWF/CSF1R/COL1A1/PIK3R1/AKT3/CCNE2/CREB3L1/CREB3/CSF3/MAGI1	1.42530651856992
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/539	56/9376	1.86376888417705	DPM2/MOGS/DPAGT1/ALG5/GANAB/MAN1A2	1.60107326583984
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/539	44/9376	1.97672457412717	DCTN1/CREB3L1/DCTN2/CREB3/DCTN5	1.60375742870586
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/539	112/9376	1.55314073681421	HLA-DRA/HLA-DRB5/HLA-DRB1/HLA-DPA1/HLA-DQA1/HLA-DPB1/MAPK14/AKT3/NFKBIB/HLA-DMA	1.45436352923608
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/539	200/9376	1.39161410018553	ACTB/F2R/GAPDH/MYO10/HCLS1/MAPK14/TUBA3E/IL1B/MYO5A/ARHGEF1/CLDN4/CLDN19/NFKBIB/CTTN/WIPF2/GNA12	1.38252886994063
NA	NA	hsa04382	Cornified envelope formation	17/539	217/9376	1.36275574326924	KRT19/S100A4/KRT7/S100A9/KRT8/S100A6/S100A8/S100A11/COL17A1/PRSS8/KRT18/COL4A5/JUP/KRT14/CLDN4/CLDN19/GBA2	1.33520431678496
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/539	143/9376	1.45973507012468	C1QB/C1QA/HLA-DRA/HLA-DRB5/C1QC/HLA-DRB1/HLA-DPA1/HLA-DQA1/FCGR3A/HLA-DPB1/HLA-DMA/C2	1.36814405830403
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/539	250/9376	1.32203339517625	EGFR/HLA-G/FOLR2/CXCR4/CAV1/IL2RB/GBF1/SH3GL1/ITCH/IGF2R/RAB31/SNX12/TGFBR1/PARD3/ACAP1/ZFYVE27/CLTB/WIPF2/AGAP3	1.2745541054326
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/539	89/9376	1.56361134852307	FN1/SPP1/COL6A3/CD44/ITGB8/COL4A5/VWF/COL1A1	1.31936391873146
NA	NA	hsa03272	Virion - Hepatitis viruses	5/539	48/9376	1.81199752628324	EGFR/CD63/CD81/CLDN4/CLDN19	1.39286379382836
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/539	90/9376	1.54623788909503	IRS2/TSC1/PIK3R1/AKT3/PRKAG2/CREB3L1/ULK1/CREB3	1.28592704261289
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/539	77/9376	1.58137965930174	EGFR/VEGFA/GADD45G/PIK3R1/AKT3/TGFBR1/RALGDS	1.26507031499634
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/539	50/9376	1.73951762523191	AOC1/MAOA/SMOX/MAOB/P4HA2	1.29483198576759
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/539	78/9376	1.56110556110556	FN1/ACTB/CAV1/HCLS1/PIK3R1/CLTB/CTTN	1.22892306891724
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/539	37/9376	1.88055959484531	MIF/MAOA/MAOB/ALDH3B1	1.32536964979116
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/539	107/9376	1.46314566608292	PHKG1/SLC2A1/PDHA1/PHKB/AKT3/PRKAG2/CREB3L1/PYGL/CREB3	1.18992789470348
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/539	122/9376	1.42583411904255	IGFBP3/CSH1/IRS2/MAPK14/PIK3R1/AKT3/STAT5A/CREB3L1/CREB3/GNA11	1.16918495018792
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/539	137/9376	1.39669298376285	ACTB/CTSB/CTSD/CTSL/CTSK/CTSW/GZMB/TUBA3E/GADD45G/PIK3R1/AKT3	1.15512747178833
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/539	93/9376	1.49635924751132	MYL9/ACTB/EGFR/TCF7L1/PTPRF/TGFBR1/PARD3/RASIP1	1.18801249896647
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/539	65/9376	1.60570857713715	CYP11A1/KCNK3/HSD3B1/CREB3L1/CREB3/GNA11	1.21017961134986
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/539	138/9376	1.38657202011239	FN1/ACTB/FYB1/MAPK14/CD4/IL1B/PIK3R1/AKT3/CCL2/ARHGEF1/WIPF2	1.12981822066363
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/539	38/9376	1.83107118445464	HEXB/GNPDA1/PMM2/GNE	1.26774142360022
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/539	139/9376	1.3765966818382	KRT19/CTSD/EGFR/MMP2/KRT18/GREB1/KRT14/PIK3R1/AKT3/CREB3L1/CREB3	1.10470421427427
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/539	170/9376	1.33021936047146	MYL9/ACTB/MYL6/HCLS1/TUBA3E/PARD3/PRKAG2/MICALL2/CLDN4/CLDN19/TJAP1/CTTN/MAGI1	1.07304787956034
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/539	201/9376	1.29814748151635	IGFBP3/HPGD/FLT1/CD14/IL1R2/NUPR1/IL2RB/GZMB/WT1/JUP/PBX3/GADD45G/CSF1R/SPI1/MEN1	1.0552460391458
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/539	83/9376	1.4670630574245	CCL4/POLR2L/CCL4L2/CCL5/DNASE2/IL1B/NFKBIB	1.05551446372602
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/539	98/9376	1.42001438794442	PTPRC/FCGR3A/MYO10/PIK3R1/AKT3/INPP5D/LYN/PLPP1	1.03223270451663
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/539	98/9376	1.42001438794442	CYP11A1/KCNK3/HSD3B1/CAMK1/CREB3L1/ATP2B4/CREB3/GNA11	1.03223270451663
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/539	69/9376	1.51262402194079	FCER1G/MAPK14/PIK3R1/AKT3/INPP5D/LYN	1.0554708303937
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/539	144/9376	1.32879818594104	C1QB/C1QA/CD14/C1QC/C5AR1/MAPK14/TCF7L1/IL1B/AKT3/PRKAG2/C2	0.981952215206575
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/539	55/9376	1.58137965930174	PSAP/HEXB/PLPP1/CERS5/GBA2	1.06791704202014
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/539	41/9376	1.69709036607991	EGFR/VEGFA/MMP2/DAPK3	1.10471802774686
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/539	15/9376	2.31935683364255	ST3GAL5/HEXB	1.26291572563313
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/539	70/9376	1.49101510734164	ELOB/VEGFA/SLC2A1/ARNT/PIK3R1/AKT3	1.01833329548937
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/539	71/9376	1.47001489456218	PRL/PRLR/MAPK14/PIK3R1/AKT3/STAT5A	0.98177100024878
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/539	71/9376	1.47001489456218	EGFR/SLC16A3/SLC2A1/PDHA1/PIK3R1/AKT3	0.98177100024878
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/539	87/9376	1.3996118823705	MT-CO2/MT-CYB/MT-CO3/MT-CO1/TPM1/TPM2/COX4I1	0.924785755252952
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/539	87/9376	1.3996118823705	EGFR/TCF7L1/GADD45G/PIK3R1/AKT3/TGFBR1/RALGDS	0.924785755252952
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/539	73/9376	1.42974051388924	CXCR4/MAP1B/CD4/NELFA/MAP1A/SUPT4H1	0.910298467744871
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/539	44/9376	1.58137965930174	MBD4/POLG2/NEIL1/APTX	0.954610923285978
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/539	30/9376	1.73951762523191	DPM2/PIGS/PGAP2	1.00189881164943
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/539	59/9376	1.47416747901009	GPX4/GPX3/GSTP1/GCLC/GSTA1	0.902292434133623
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/539	59/9376	1.47416747901009	EGFR/TCF7L1/GADD45G/PIK3R1/AKT3	0.902292434133623
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/539	136/9376	1.2790570773764	IL2RB/CD3D/IL1B/PIK3R1/AKT3/CCNE2/CD3G/STAT5A/NFKBIB/CD3E	0.809569435294688
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/539	168/9376	1.24251258945136	PRL/PRLR/EGFR/CSH1/IL7R/IL2RB/IL15/PIK3R1/AKT3/STAT5A/CSF3/PTPN2	0.783310354930779
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/539	60/9376	1.44959802102659	MAPK14/VEGFA/PIK3R1/AKT3/HSPB1	0.862805429744562
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/539	122/9376	1.2832507071383	EEF2/IRS2/TSC1/PIK3R1/AKT3/PRKAG2/CREB3L1/ULK1/CREB3	0.777702981294203
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/539	122/9376	1.2832507071383	PTPRC/MAPK14/CD4/CD3D/PIK3R1/AKT3/CD3G/NFKBIB/CD3E	0.777702981294203
NA	NA	hsa04517	IgSF CAM signaling	20/539	299/9376	1.16355693995446	MYL9/ACTB/MYL6/CLMP/ITGB2/MBP/MAPK14/TUBA3E/FGG/PTPRF/PIK3R1/AKT3/PARD3/CD2/RASA1/CD84/INPP5D/LYN/ROBO3/MAGI1	0.709840862691775
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	31/539	480/9376	1.12343846629561	MT-CO2/MT-CYB/MT-CO3/MT-ND3/MT-CO1/MT-ND2/MT-ATP6/MT-ND1/MT-ND4/DKK1/UBA52/MT-ND5/WNT4/ATG14/CYBB/GPX3/MAPK14/PSMA7/DCTN1/TUBA3E/PSMD6/IL1B/ATP5F1D/WNT10B/DCTN2/ULK1/ATXN1/NDUFA13/DCTN5/COX4I1/NDUFS1	0.685648202678609
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	20/539	300/9376	1.15967841682127	FLT1/CD14/EGFR/RASGRP2/FLNA/MAPK14/VEGFA/MAP3K3/IL1B/GADD45G/CSF1R/AKT3/TGFBR1/RASA1/NFKB2/DUSP3/HSPB1/MAP4K4/DUSP4/GNA12	0.694204133197829
NA	NA	hsa04081	Hormone signaling	15/539	219/9376	1.19145042824103	PRL/RAMP1/PRLR/DIO2/CSH1/IRS2/ADRA2C/GNB5/TRH/PIK3R1/SLC40A1/STAT5A/PRKG1/GNA12/GNA11	0.707993687872483
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	22/539	333/9376	1.14923086351658	FN1/SPP1/EGFR/HLA-G/COL6A3/WNT4/ITGB8/TSC1/VEGFA/TCF7L1/COL4A5/VWF/COL1A1/PIK3R1/AKT3/CCNE2/PARD3/ATP6V1H/WNT10B/CREB3L1/CREB3/MAGI1	0.684781622484715
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/539	77/9376	1.35546827940149	GADD45G/PIK3R1/AKT3/TGFBR1/CTBP2/STAT5A	0.773491746742139
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/539	62/9376	1.40283679454186	CRYAB/IRS2/PIK3R1/AKT3/PRKAG2	0.785931060633532
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/539	62/9376	1.40283679454186	ITCH/CTBP2/PSENEN/APH1B/ATXN1	0.785931060633532
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/539	205/9376	1.18796325625594	HLA-G/PIK3R1/CCNE2/LTBR/NFKB2/STAT5A/CREB3L1/LYN/GTF2H3/VAC14/CREB3/MRPS18B/HDAC11/SND1	0.671999789773066
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/539	33/9376	1.58137965930174	STX3/STX18/VAMP8	0.826230498315271
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/539	63/9376	1.38056954383485	PRDM2/SMYD3/SETD7/PLOD3/KMT2B	0.748491885104035
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/539	63/9376	1.38056954383485	POLR2L/ERCC6/CETN2/POLR2J/GTF2H3	0.748491885104035
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/539	94/9376	1.29538546559823	S100A9/S100A8/MAPK6/MAPK14/IL1B/CCL2/CSF3	0.710820362232515
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/539	110/9376	1.26510372744139	DCN/EMP3/FMOD/TGFBR1/BMP8B/LTBP1/FBN1/NOG	0.690706625664518
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/539	19/9376	1.83107118445464	HEXB/GUSB	0.895517966545651
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/539	49/9376	1.42001438794442	MAOA/MAOB/CREB3L1/CREB3	0.727978935123297
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/539	80/9376	1.30463821892393	EGFR/AXL/VEGFA/RPS6/PIK3R1/AKT3	0.675785574336035
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/539	65/9376	1.33809048094762	SPP1/TRPC1/PIK3R1/AKT3/GNA11	0.67549019822059
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/539	20/9376	1.73951762523191	CYB5R1/GNE	0.817609659544969
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/539	194/9376	1.16565614061932	MYL9/ACTB/TPM1/MYL6/TPM2/MYO10/DCTN1/TUBA3E/MYO5A/KIF21A/HOOK3/DCTN2/DCTN5	0.575794289223542
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/539	115/9376	1.21009921755263	EGFR/GATA3/PDE4D/ARHGEF1/CREB3L1/CREB3/GNA12/GNA11	0.559850417470604
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/539	21/9376	1.65668345260182	CHPF/XYLT2	0.743997399623611
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/539	21/9376	1.65668345260182	BCAT1/PPCDC	0.743997399623611
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/539	99/9376	1.22996195723468	EGFR/TSC1/PIK3R1/AKT3/SLC44A1/RALGDS/PLPP1	0.568064184530247
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/539	149/9376	1.16746149344424	MT-ND3/MT-ND2/MT-ND1/MT-ND4/MT-ND5/GNB5/MAPK14/CNR1/NDUFA13/NDUFS1	0.508868335015852
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/539	133/9376	1.17711719000656	TYROBP/HLA-G/FCER1G/FCGR3A/ITGB2/HCST/GZMB/MICA/PIK3R1	0.508051397943452
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/539	232/9376	1.12468811976201	FN1/MYL9/ACTB/RGCC/EGFR/CXCR4/F2R/ITGB2/ITGB8/PIK3R1/AKT3/PFN1/ARHGEF1/ITGAE/GNA12	0.474928851169971
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/539	150/9376	1.15967841682127	EGFR/WNT4/TCF7L1/JUP/GADD45G/PIK3R1/AKT3/CCNE2/TGFBR1/WNT10B	0.48686966451052
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/539	70/9376	1.24251258945136	IRS2/SLC2A1/AKT3/PRKAG2/NFKBIB	0.502955287365203
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/539	103/9376	1.18219644433237	COL6A3/SLC7A8/COL17A1/COL4A5/COL14A1/COL1A1/COL5A1	0.459172608742331
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/539	253/9376	1.10009019777512	MYL9/ACTB/CD14/EGFR/UBA52/CD44/ATG14/HCLS1/MAPK14/CCL5/IL1B/PIK3R1/AKT3/PFN1/NFKBIB/CTTN	0.398575467215553
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/539	170/9376	1.12557022809124	ACTB/EGFR/WNT4/GSTP1/TCF7L1/GSTA1/GADD45G/PIK3R1/AKT3/TGFBR1/WNT10B	0.408040481929449
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/539	71/9376	1.22501241213515	EGFR/MAPK14/CCL5/ATP6V1H/LYN	0.470007788021474
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/539	105/9376	1.15967841682127	UBA52/GABARAP/RABGEF1/CITED2/SAMM50/FUNDC1/ULK1	0.406354590565306
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/539	105/9376	1.15967841682127	FCER1G/MAPK14/LSP1/IL1B/PIK3R1/AKT3/NFKB2	0.406354590565306
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/539	56/9376	1.24251258945136	CD14/ITGB2/IL1B/NFKB2	0.449518882553989
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/539	24/9376	1.44959802102659	XYLT2/EXT2	0.544634760428507
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/539	73/9376	1.19145042824103	MAOA/GSTP1/MAOB/GSTA1/ALDH3B1	0.405540147703715
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/539	73/9376	1.19145042824103	EGFR/GADD45G/PIK3R1/AKT3/STAT5A	0.405540147703715
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/539	174/9376	1.09969505043397	CRYAB/SSR4/DNAJB2/MOGS/SEC62/GANAB/MAN1A2/NSFL1C/BAG1/RRBP1/SSR1	0.327819437213692
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/539	91/9376	1.14693469795511	CD81/PIK3R1/AKT3/INPP5D/NFKBIB/LYN	0.347841744083771
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/539	108/9376	1.12746512746513	NUP214/KPNA1/POM121/NUP133/SNUPN/THOC5/NUP88	0.32903177709338
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/539	42/9376	1.24251258945136	AOC1/MAOA/MAOB	0.389002711991615
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/539	59/9376	1.17933398320808	IRS2/PIK3R1/AKT3/PRKG1	0.341254310754297
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/539	76/9376	1.14441949028415	EGFR/CAMK1/GADD45G/PIK3R1/AKT3	0.312189809715875
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/539	93/9376	1.12226943563349	FN1/COL4A5/GADD45G/PIK3R1/AKT3/CCNE2	0.292646139872413
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/539	195/9376	1.0704723847581	ACTB/FCGR3A/ITGB2/CYBB/C5AR1/MAPK14/VWF/FGG/PIK3R1/AKT3/FPR3/HDAC11	0.245594633839726
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/539	196/9376	1.06501079095831	HLA-G/UBA52/RCAN1/ATG14/GNB5/MAPK14/VEGFA/TCF7L1/MICA/PIK3R1/AKT3/LYN	0.227153659774282
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/539	60/9376	1.15967841682127	LYN/PRKG1/GNA12/GNA11	0.306432409848756
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/539	61/9376	1.14066729523404	FTL/FTH1/SLC40A1/ATP2B4	0.272203821527716
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/539	216/9376	1.04693190407476	CD14/APOA1/CYBB/MAPK14/CCL5/IL1B/PIK3R1/AKT3/SELE/CCL2/ARHGEF1/POU2F1/LYN	0.172335562638324
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/539	166/9376	1.04790218387465	MYL9/IRS2/ADRA2C/AKT3/CREB3L1/ATP2B4/CREB3/PRKG1/GNA12/GNA11	0.153782577499651
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/539	149/9376	1.05071534409981	EGFR/FCER1G/F2R/TSC1/PIK3R1/AKT3/RALGDS/PLPP1/GNA12	0.154109653395759
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/539	184/9376	1.03992901508429	MYL9/SEMA3B/CXCR4/WNT4/TRPC1/SEMA5A/PIK3R1/PARD3/RASA1/ABLIM3/ROBO3	0.135089033554209
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/539	63/9376	1.10445563506788	WNT4/TCF7L1/GADD45G/WNT10B	0.205439968773815
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/539	46/9376	1.13446801645559	FTL/FTH1/GUSB	0.225779593031925
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/539	134/9376	1.03851798521308	MYL9/RAMP1/MYL6/CALD1/ARHGEF1/PRKG1/GNA12/GNA11	0.110907412318452
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/539	12/9376	1.44959802102659	COQ7	0.384868090169184
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/539	30/9376	1.15967841682127	PDHA1/SUCLG1	0.216332391008432
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/539	30/9376	1.15967841682127	FOLR2/IL1B	0.216332391008432
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/539	154/9376	1.01660120955112	DHRS3/QPRT/GCLC/BCAT1/COQ7/PMM2/GUSB/UMPS/PPCDC	0.0512997355489088
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/539	13/9376	1.33809048094762	XRCC4	0.30124836672985
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/539	31/9376	1.12226943563349	SMOX/ALDH3B1	0.168397909160253
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/539	31/9376	1.12226943563349	SEC62/SRP19	0.168397909160253
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/539	67/9376	1.03851798521308	TPI1/GAPDH/PDHA1/ALDH3B1	0.078140653974426
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	9/539	157/9376	0.997175708731669	IGFBP3/HLA-G/TSC1/MAPK14/GADD45G/PIK3R1/AKT3/CCNE2/TGFBR1	-0.00881343072764401
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/539	122/9376	0.998083883329785	ACTB/DIO2/RCAN1/WNT4/SLC2A1/PIK3R1/AKT3	-0.00526095649323912
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/539	14/9376	1.24251258945136	B4GALT4	0.224254714310837
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/539	69/9376	1.00841601462719	MAOA/MAOB/CREB3L1/CREB3	0.0173282124266052
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/539	33/9376	1.05425310620116	PDHA1/BCAT1	0.0771020627477262
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/539	178/9376	0.977257092826916	NOTUM/DKK1/WNT4/APCDD1/TCF7L1/LGR4/CTBP2/WNT10B/ANKRD6/SERPINF1	-0.0756548667324311
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/539	214/9376	0.975430444055277	HLA-G/ELOB/CXCR4/GNB5/MAPK14/CD4/CD3D/PIK3R1/AKT3/CD3G/CD3E/GNA11	-0.089791792960027
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/539	125/9376	0.97412987012987	CTSD/FCER1G/MAPK14/PIK3R1/AKT3/CERS5/GNA12	-0.0719095992148129
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/539	34/9376	1.02324566190112	POLR2L/POLR2J	0.0335342839370203
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/539	34/9376	1.02324566190112	RORB/PRKAG2	0.0335342839370203
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/539	35/9376	0.994010071561092	TPI1/PMM2	-0.00876771780657953
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/539	73/9376	0.953160342592828	EGFR/GADD45G/PIK3R1/AKT3	-0.0992181723374414
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/539	16/9376	1.08719851576994	HEXB	0.0862102199271837
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/539	36/9376	0.966398680684395	CRYL1/GUSB	-0.0498840533867132
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/539	148/9376	0.940279797422655	EGFR/WNT4/TCF7L1/GADD45G/PIK3R1/AKT3/WNT10B/NFKB2	-0.180853088715808
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/539	93/9376	0.935224529694576	EGFR/MAPK14/MMP2/MAP3K3/GNA11	-0.155037039674617
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/539	75/9376	0.927742733457019	GSTP1/GSTA1/PIK3R1/AKT3	-0.155158270924364
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/539	75/9376	0.927742733457019	IGFBP3/CD82/GADD45G/CCNE2	-0.155158270924364
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/539	17/9376	1.02324566190112	ADO	0.0236907738611755
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/539	37/9376	0.940279797422655	PMM2/GNE	-0.089887549279726
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/539	37/9376	0.940279797422655	TCF7L1/GADD45G	-0.089887549279726
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/539	187/9376	0.930223329001022	CTSB/GABARAP/CYBB/MAPK14/CCL5/IL1B/CCL2/NFKBIB/ANTXR1/TXN2	-0.23802606472307
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/539	133/9376	0.915535592227322	MAOA/GNB5/MAPK14/MAOB/AKT3/CREB3L1/CREB3	-0.242281736988864
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/539	38/9376	0.915535592227322	SCNN1B/PIK3R1	-0.128844593045963
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/539	115/9376	0.907574413164475	GNB5/PIK3R1/AKT3/CREB3L1/CREB3/GNA11	-0.246286035605397
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/539	18/9376	0.966398680684395	HCFC1	-0.0352394121603138
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/539	154/9376	0.903645519600993	MYL9/ACTB/MYL6/EGFR/EEF2/RCAN1/CAMK1/PRKAG2	-0.297746941161228
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/539	117/9376	0.892060320631749	ACTB/GATAD2B/VPS72/EP400/MRGBP/TFPT	-0.290148016360436
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/539	79/9376	0.880768417838942	HSD11B1/GSTP1/GSTA1/ALDH3B1	-0.262821585192678
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/539	19/9376	0.915535592227322	PDHA1	-0.0910143392153669
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/539	99/9376	0.878544255167632	EGFR/MAPK14/MMP2/PIK3R1/AKT3	-0.300026402081373
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/539	99/9376	0.878544255167632	ACTB/TPM1/TPM2/ITGB8/PRKAG2	-0.300026402081373
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/539	157/9376	0.886378407761483	ACTB/WNT4/ITGB2/TCF7L1/TGFBR1/PARD3/WNT10B/BMP8B	-0.354565424461496
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/539	41/9376	0.848545183039957	MAOA/MAOB	-0.240018905476711
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/539	20/9376	0.869758812615955	SOAT1	-0.143994475915847
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/539	158/9376	0.880768417838942	WNT4/TSC1/RPS6/PIK3R1/AKT3/ATP6V1H/WNT10B/ULK1	-0.373275161302929
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/539	101/9376	0.861147339223718	WNT4/TCF7L1/WNT10B/CREB3L1/CREB3	-0.346485869218323
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/539	82/9376	0.848545183039957	GSTP1/GSTA1/GUSB/UMPS	-0.340185874013164
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/539	63/9376	0.82834172630091	HPGD/PTGDS/GPX4	-0.337611947556405
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/539	83/9376	0.838321747099716	PEX6/PEX26/PXMP4/SLC25A17	-0.365376219963163
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/539	142/9376	0.857508688494604	ELOB/UBA52/ITCH/UBE3B/UBE2F/UBE2Q2/UBE2O	-0.422537456937041
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/539	43/9376	0.809077965224145	APOA1/PLPP1	-0.309889771983318
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/539	163/9376	0.853750981708913	MAPK14/PIK3R1/AKT3/CCNE2/TGFBR1/STAT5A/CREB3L1/CREB3	-0.465172272054276
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/539	44/9376	0.790689829650869	HEXB/MAN1A2	-0.343682087553785
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/539	44/9376	0.790689829650869	TAF6/GTF2H3	-0.343682087553785
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/539	144/9376	0.845598845598846	ATG14/PSMA7/PSMD6/PIK3R1/AKT3/ULK1/ATXN1	-0.461117372532743
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/539	86/9376	0.809077965224145	EGFR/PIK3R1/AKT3/STAT5A	-0.439263397369727
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/539	86/9376	0.809077965224145	SLC2A1/CREB3L1/CREB3/GNA11	-0.439263397369727
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/539	86/9376	0.809077965224145	ACTB/ITGB8/TCF7L1/JUP	-0.439263397369727
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/539	66/9376	0.790689829650869	HSD11B1/CYP11A1/HSD3B1	-0.421419911663286
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/539	23/9376	0.756312010970396	B3GALNT2	-0.288968276847248
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/539	46/9376	0.756312010970396	PSMA7/PSMD6	-0.409166257078252
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/539	89/9376	0.781805674261533	EGFR/TUBA3E/PRKG1/GNA11	-0.510773463674303
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/539	47/9376	0.740220266056132	IRS2/PIK3R1	-0.440924512492479
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/539	48/9376	0.724799010513296	PIK3R1/AKT3	-0.472067317786458
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/539	70/9376	0.745507553670819	HSD11B1/GSTP1/GSTA1	-0.527800728883134
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/539	26/9376	0.669045240473812	APOA1	-0.417327585799558
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/539	154/9376	0.790689829650869	TPM1/TPM2/MAPK14/AKT3/CREB3L1/ATP2B4/CREB3	-0.646793617871366
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/539	27/9376	0.64426578712293	FADS1	-0.457143481147633
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/539	51/9376	0.682163774600749	PLA2G7/PLPP1	-0.562071617398312
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/539	51/9376	0.682163774600749	ACTB/ATP6V1H	-0.562071617398312
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/539	156/9376	0.780552780552781	EGFR/CD81/NR1H3/PIK3R1/AKT3/CLDN4/CLDN19	-0.682581501444554
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/539	217/9376	0.801621025452493	EGFR/KPNA1/VEGFA/ARNT/GSTA1/PIK3R1/AKT3/STAT5A/CREB3L1/CREB3	-0.730178551518096
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/539	52/9376	0.669045240473812	CYP11A1/HSD3B1	-0.591012632635148
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/539	28/9376	0.621256294725682	B4GALT4	-0.495670052839281
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/539	28/9376	0.621256294725682	QDPR	-0.495670052839281
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/539	158/9376	0.770672365609074	CDKN1C/MCM7/PDS5A/GADD45G/CCNE2/SMC1A/SMC3	-0.717949960630905
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/539	75/9376	0.695807050092764	TPI1/GAPDH/BCAT1	-0.65319454212835
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/539	75/9376	0.695807050092764	GPX3/CREB3L1/CREB3	-0.65319454212835
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/539	53/9376	0.656421745370532	ATP2B4/CLTB	-0.619460124009509
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/539	76/9376	0.686651694170491	PLTP/APOA1/NR1H3	-0.677361121959596
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/539	140/9376	0.745507553670819	SPP1/GNB5/RPS6/AKT3/TGFBR1/PRKAG2	-0.749246193894709
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/539	54/9376	0.64426578712293	GCLC/BCAT1	-0.647434084829924
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/539	120/9376	0.724799010513296	MAPK14/MAP3K3/PIK3R1/AKT3/NFKBIB	-0.749301383411444
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/539	78/9376	0.669045240473812	TPI1/INPP4B/INPP5D	-0.72485102081028
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/539	78/9376	0.669045240473812	MTREX/TENT4A/EXOSC9	-0.72485102081028
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/539	79/9376	0.660576313379207	STX3/ATP6V1H/CLTB	-0.748189948944215
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/539	56/9376	0.621256294725682	GAS1/CSNK1G1	-0.702035500731858
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/539	31/9376	0.561134717816745	GUSB	-0.604435569198303
NA	NA	hsa04981	Folate transport and metabolism	1/539	31/9376	0.561134717816745	FOLR2	-0.604435569198303
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/539	32/9376	0.543599257884972	SUCLG1	-0.638678813023688
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/539	32/9376	0.543599257884972	GABARAP	-0.638678813023688
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/539	32/9376	0.543599257884972	BOK	-0.638678813023688
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/539	105/9376	0.662673381040728	ACTB/TPM1/TPM2/ITGB8	-0.858439248476513
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/539	83/9376	0.628741310324787	HCFC1/CBX7/YAF2	-0.839006447859557
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/539	36/9376	0.483199340342198	PYGL	-0.76723510331589
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/539	36/9376	0.483199340342198	MCM7	-0.76723510331589
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/539	110/9376	0.632551863720695	MAPK14/CPEB4/PIK3R1/AKT3	-0.957356823178979
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/539	238/9376	0.730889758500803	FLT1/EGFR/RASGRP2/GNB5/VEGFA/CSF1R/PIK3R1/AKT3/RASA1/RALGDS	-1.03853400408022
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/539	89/9376	0.58635425569615	GABARAP/GNB5/TRAK2	-0.968307809275743
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/539	65/9376	0.53523619237905	MBOAT2/PLPP1	-0.928578041167233
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/539	38/9376	0.457767796113661	QPRT	-0.827137601369052
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/539	91/9376	0.573467348977553	GNB5/PDE4D/PDE7B	-1.00974013153553
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/539	115/9376	0.605049608776317	MAOA/GNB5/MAOB/TRPC1	-1.0524224886814
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/539	138/9376	0.630260009141997	MAPK14/CPEB4/CCNE2/SMC1A/SMC3	-1.08062393770227
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/539	116/9376	0.599833663873073	TPI1/GAPDH/PDHA1/SUCLG1	-1.07100536292576
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/539	68/9376	0.511622830950562	ALDH1A2/DHRS3	-0.998180807974909
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/539	226/9376	0.692728257835717	MYL9/FXYD1/F2R/PDE4D/PIK3R1/AKT3/CREB3L1/ATP2B4/CREB3	-1.15476573473622
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/539	93/9376	0.561134717816745	LYZ/ATP2B4/PRKG1	-1.05040339876868
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/539	144/9376	0.603999175427747	WNT4/MAPK14/PIK3R1/AKT3/WNT10B	-1.1826521664024
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/539	72/9376	0.483199340342198	MAPK14/NFKBIB	-1.08713142548094
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/539	254/9376	0.684849458752721	FLT1/EGFR/CXCR4/F2R/PHKG1/VEGFA/PHKB/CAMK1/ATP2B4/GNA11	-1.25752745328455
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/539	98/9376	0.532505395479156	INPP4B/PIK3R1/INPP5D	-1.14892068896302
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/539	168/9376	0.621256294725682	FTL/FTH1/CYBB/IL1B/STAT5A/PYGL	-1.22333387671703
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/539	99/9376	0.527126553100579	MAPK14/IL1B/PIK3R1	-1.16811698869299
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/539	45/9376	0.386559472273758	ABCA5	-1.01869041603139
NA	NA	hsa04519	Cadherin signaling	17/539	404/9376	0.731975238340161	KRT19/ACTB/KRT7/KRT8/EGFR/WNT4/CDH11/MAPK14/KRT18/TCF7L1/JUP/KRT14/WNT10B/ANKRD6/PSENEN/APH1B/RERE	-1.36003023047192
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/539	102/9376	0.511622830950562	TRPC1/ATP2B4/RAB3D	-1.22475574836344
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/539	47/9376	0.370110133028066	PDHA1	-1.06911296852188
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/539	48/9376	0.362399505256648	BCAT1	-1.09371102165806
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/539	54/9376	0.322132893561465	USP1	-1.23371397466625
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/539	57/9376	0.305178530742441	FADS1	-1.29943211051011
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/539	191/9376	0.546445327297982	MAOA/GNB5/MAOB/CREB3L1/CREB3/HDAC11	-1.56399133346688
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/539	59/9376	0.294833495802019	UMPS	-1.34186005938368
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/539	97/9376	0.358663427882868	GNB5/PRKG1	-1.56801018482503
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/539	128/9376	0.407699443413729	PDE4D/GUK1/PDE7B	-1.6662908454725
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/539	69/9376	0.252104003656799	CTSB	-1.53988571452404
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/539	103/9376	0.33777041266639	FIP1L1/SMG6	-1.6689551122503
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/539	104/9376	0.334522620236906	MBOAT2/PLPP1	-1.68535288742065
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/539	76/9376	0.22888389805683	ACTB	-1.66691205363507
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/539	370/9376	0.564167878453593	PRL/NPW/PRLR/TAC3/CSH1/F2R/ADRA2C/C5AR1/TRH/CHRNB1/CNR1/FPR3	-2.11242704638551
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/539	116/9376	0.299916831936536	GNB5/TRPC1	-1.87370290751345
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/539	85/9376	0.204649132380225	GUK1	-1.81913355721134
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/539	86/9376	0.202269491306036	SCNN1B	-1.83537648677263
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/539	90/9376	0.193279736136879	SLC2A1	-1.89914215735576
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/539	243/9376	0.42951052474862	EFTUD2/DHX38/THOC5/SF3A2/CTNNBL1/PRPF38B	-2.22521325351203
NA	NA	hsa04082	Neuroactive ligand signaling	4/539	199/9376	0.349651783966213	TAC3/ADRA2C/GNB5/GNA11	-2.29007506958047
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/539	323/9376	0.43084027869521	TIMP3/TPM1/EGFR/CD44/IRS2/VEGFA/PIK3R1/CCNE2	-2.57079089040711
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/539	183/9376	0.28516682380851	GTPBP4/MPHOSPH10/POP4	-2.41173290319314
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/539	449/9376	0.0387420406510448	PRKG1	-5.1551101013448